CN101181622B - Method for preparing water extraction of white vein ointment - Google Patents
Method for preparing water extraction of white vein ointment Download PDFInfo
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- CN101181622B CN101181622B CN200710188506XA CN200710188506A CN101181622B CN 101181622 B CN101181622 B CN 101181622B CN 200710188506X A CN200710188506X A CN 200710188506XA CN 200710188506 A CN200710188506 A CN 200710188506A CN 101181622 B CN101181622 B CN 101181622B
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Abstract
The invention provides a novel preparation method for Tibetan medical white vein ointment. Based on the primary prescription of Tibetan medical white vein ointment, By combining modern advanced technique, the invention can effectively remain the effective components of the active substances and medical materials, and greatly increase the dissolution rate of the components of crude medicines, as well as increase the biological utilization degree and overcome the shortcomings of the traditional white vein ointment. The product produced by the invention has no odor, good stability, and is easy for using, carrying and storing. Besides, the invention has the advantages of simple technique, easy operation, stable source of the raw materials and auxiliary materials, and easy industrialization.
Description
Technical field
The invention belongs to field of traditional Chinese, relate to a kind of preparation method of the lung-pulse ointment, be specifically related to a kind of prescription, adopt modern advanced technologies to prepare the new method of the lung-pulse ointment based on traditional Tibetan medicine the lung-pulse ointment.
Background technology
To be the doctor among the people of Tibetan carry according to " Tibetan medicine doctor determine addendum release difficulty ", the Four-Volume Medical Code two secretaries the lung-pulse ointment, and in conjunction with the classical Tibetan medicine and pharmacology proved recipe that practical experience is formed, its prescription is former to be recorded in first 310 pages of " health drug standard promulgated by the ministries or commissions of the Central Government " 95 years version Tibetan medicines.The prescription of the lung-pulse ointment is:
Rhizoma Curcumae Longae 150g Semen Myristicae 50g Radix Et Rhizoma Nardostachyos 80g Actinolitum 50g Radix Glycyrrhizae 70g Moschus 0.7g
Rhizoma Kaempferiae 100g Fructus cari carvi 130g Rhizoma Acori Calami 70g Pericarpium Zanthoxyli 50g trona 75g
Method for making: above ten simply, and except that other porphyrize powder of Moschus, all the other are ground into fine powder altogether, sieve, and adds Moschus fine powder facing-up, with butter or Adeps Sus domestica furnishing ointment, promptly.
Function with cure mainly: relaxing muscles and tendons and activating QI and blood in the collateral.Be used for aortic arch syndrome, paralysis, hemiplegia, the muscle tendon is tetanic, meridians that wound causes and muscle tendon break wound, brothers' contraction urgency, limping etc.
The preparation technology of tradition Tibetan medicine the lung-pulse ointment is modulated into ointment after all crude drug fine powders are mixed, and its technology is numerous and diverse, batch production cycle is long, the production technology instability; Raw material and adjuvant source are unstable, are unfavorable for suitability for industrialized production; Part drug osmotic ability, bioavailability is low, can not guarantee curative effect fully, is difficult for the curative effect of performance medicine; Product is not easy to store in addition, carries inconvenience; Because each side has greatly influenced the curative effect and the popularization of product.
Summary of the invention
The objective of the invention is in order to overcome existing Tibetan medicine ointment preparation technology's deficiency, provide a kind of bioavailability height, onset of product rapid, Transdermal absorption good, produces the preparation method of the Tibetan medicine the lung-pulse ointment that is easy to industrialization.
The prescription of the lung-pulse ointment of the present invention with traditional Tibetan medicine the lung-pulse ointment prescription be that the basis is amplified and formed, its concrete prescription is:
Composition of raw materials: by weight
Rhizoma Curcumae Longae 16～20%, Semen Myristicae 4～8%, Radix Et Rhizoma Nardostachyos 8～12%, Actinolitum 4～8%, Radix Glycyrrhizae 6～10%, artificial Moschus or Moschus 0.06～0.1%, Rhizoma Zingiberis 10～14%, Fructus cari carvi 13～19%, Rhizoma Acori Calami 6～10%, Pericarpium Zanthoxyli 4～8%, trona 7～11%.
Preparation technology:
1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona remove impurity, clean system back are mixed;
2. take by weighing above-mentioned hybrid medicine total amount 10%～100%,, decoct 1～4 time down, fried in shallow oil collection respectively, merge extractive liquid, and volatile oil at every turn 0.5～3 hour in 70～100 ℃ with 5～20 times of water of medicine gross weight; Filter, it is 1.0～1.5 concentrated solutions that concentrated extracting solution becomes relative density, enters subsequent processing; Volatile oil joins and extracts in the concentrated solution.
3. will remain the medicated powder that hybrid medicine is ground into 0.01～200 μ m, and mix, obtain mixed liquor a with above-mentioned concentrated medicament; Add the water of 1～100 times of mixed liquor a weight then, stir, obtain mixed liquor b.Above-mentioned water is at least a in glycerol, propylene glycol, the water.
4. with mixed liquor b and oil phase and emulsifying agent with 100: 0: 1～100: 95: 100 weight ratio mix, emulsifying, emulsifying ointment; Emulsification condition is: in 20～90 ℃, normal pressure stirred 1～40 minute; Or in 20～90 ℃, vacuum pressure is to stir 1～40 minute under the condition of 0.01～0.09Mpa.
Described oil phase is at least a in liquid paraffin, Cera Flava, vaseline, the lanoline; Described emulsifying agent is that Tween-80, triethanolamine, hexadecanol, octadecanol, glyceryl stearate, fatty acid Pyrusussuriensis are smooth, at least a in the sodium lauryl sulfate, carbomer, polypropylene type.
5. the artificial Moschus of formula ratio or Moschus are joined to stir in the above-mentioned emulsifying ointment and get final product.The water that artificial Moschus or Moschus can add 2～30 times of weight portions earlier grinds, cross 80～200 mesh sieves after, add again in the emulsifying ointment of step in 4..
For the viscosity of reconciling emulsifying ointment and the stability that increases mastic, 5. step also adds the thickening agent of emulsifying ointment body weight 0.1%～10% or/and suspending agent.Thickening agent can adopt at least a in methylcellulose, Sodium Tvlose, Polyethylene Glycol, sodium polyacrylate, hydroxypropyl emthylcellulose, hydroxyethyl-cellulose, glyceryl monostearate, the glycerin gelatine; Suspending agent can adopt at least a in gelatin, carbomer, vaseline, the hard paraffin.
For the ease of the long-term storage of emulsifying ointment, 5. step also adds the antiseptic of emulsifying ointment body weight 0.1%～～10%.Antiseptic can adopt benzoic acid, sodium benzoate, sodium nitrite, propanoic acid, sodium propionate, calcium propionate, nipalgin, glycerol, sorbic acid, fragrant wet goods.
The present invention compared with prior art has the following advantages:
1, the medicine process stabilizing made than prior art of the lung-pulse ointment product made of method of the present invention, quality is high and controlled, helps guaranteeing curative effect, can measure and the detection of effective ingredient medicament contg, to guarantee the quality of traditional Tibetan medicine ointment.
2, the present invention adopts modern advanced, has preserved the effective ingredient of medicine.Because the present invention has adopted modern Multifunction tank to extract and the triple effect concentration technique, not only keep active substance in the natural plant crude drugs and the effective ingredient in the medical material effectively, improved the content and the ratio of crude drug composition again greatly, make curative effect better; Solved the Transdermal absorption problem simultaneously, onset is rapider, and prolongs the medicine resting period greatly, and is easy to use and carry.
3, the present invention has improved the bioavailability of product.With the lung-pulse ointment that method of the present invention is made, need not add the stabilizing agent of any chemosynthesis, safe in utilization.
4, the present invention makes production technology simple by technological improvement, is easy to industrialization.Overcome the shortcoming that original product can not suitability for industrialized production.
For showing the curative effect that is higher than the lung-pulse ointment of traditional handicraft preparation evident in efficacy of medicine of the present invention, carried out the dependency experiment of this medicine, specific as follows:
1. experiment material
1.1 be subjected to reagent: be the lung-pulse ointment of the present invention, yellowish-brown ointment is provided by Gansu Qizheng Tibetan Medicine Co., Ltd's production, the suitable 0.2g crude drug of every g ointment, and room temperature is preserved.
1.2 dosage is selected in test for use: 0.3g crude drug/kg/d, 0.15g crude drug/kg/d, 0.075g crude drug/kg/d (are respectively 20 times, 10 times, 5 times of clinical dosage; Skin is smeared administration.
2. contrast medicine:
2.1 former technology contrast medicine: the lung-pulse ointment of former traditional handicraft provides the suitable 0.2g crude drug of every g ointment by the production of Tibet Linzhi's Qizheng Tibetan Medicine factory.
Prescription: get Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g
Technology: above ten simply, and except that other porphyrize powder of Moschus, all the other are ground into 200 order fine powders altogether, sieve, and adds Moschus fine powder facing-up, adds to 1000g furnishing ointment with butter, promptly.
2.2 dosage: 0.3g crude drug/kg/d, skin is smeared administration.
3. laboratory animal
ICR kind mice, body weight 18～22g; SD, Wistar kind rat, body weight 180～250g.
4. test method and result
4.1 therapeutical effect to the apoplexy rat model
80 of SD rats are selected in test for use, complete male, 10% chloral hydrate 350mg/kg anesthetized rat, it is fixing to lie on one's side, cut an osculum from the eye corner of the eyes and external auditory meatus midline, bite away zygomatic arch with rongeur, expose the squamosal bone major part, the about 2mm in the front lower place of before zygomatic arch and squamosal bone, uniting place boring then, open about 2mm diameter microcephalia window, expose intraluminal middle cerebral artery occlusion in rats, have the little filter paper of 50% liquor ferri trichloridi to apply suction, remove filter paper after 30 minutes at this section middle cerebral artery place, the normal saline flushing local organization, steam again behind the layer-by-layer suture then and raise, make intraluminal middle cerebral artery occlusion in rats thrombosis local cerebral ischemia model, observed animal behavior state and scoring in back 48 hours in making to rub.Be divided into 4 groups with the score value equilibrium, 20 every group.With the rat neck unhairing, smear administration by the skin of dosage shown in the table 1, every day 1 time, successive administration 30 days, the positive drug group is irritated stomach and is given corresponding medicinal liquid, and the excipient group is coated with outward and gives with volume dressing.In administration the 15th day, carried out behavioristics scoring on the 30th day.Get each administration cell mean and excipient cell mean relatively, carry out statistics t check.Result's (seeing Table 1) shows, administration group rat behavior is learned scoring relatively has significant difference with the excipient group, show that the lung-pulse ointment can improve apoplexy rat model behavior harmony, good to the apoplexy more former technology group therapeutical effect that has significant therapeutic effect, significant difference is arranged.
Table 1 the lung-pulse ointment is to the therapeutical effect n=20 of apoplexy rat model
4.2 rat self absorption of hematoma test
30 rats are selected in test for use, are divided into 3 groups at random, and 10 every group, male and female half and half.Tested preceding 1 day, every right back shank of rat is lost hair or feathers with 8% sodium sulfide.Press dosage shown in the table 4, the lung-pulse ointment is respectively organized coating medicine-feeding every day; The excipient group is coated with outward and gives with the volume excipient, every day 1 time, successive administration 7 days.Get blood 0.1ml by rat eye socket venous plexus after the 3rd administration, be subcutaneously injected into depilation place, each is organized after the last administration 24 hours and traces the hematoma form with transparent template, and cuts and weigh, and represents the hematoma area with the weight of template.Get each administration cell mean and excipient cell mean relatively, carry out statistics t check.Result's (seeing Table 2) shows that administration group hematoma area obviously dwindles, and with the excipient group significant difference of highly significant is arranged relatively, shows that of the present invention group of more former technology group therapeutical effect is good, and significant difference is arranged.
Table 2 the lung-pulse ointment is to the influence of rat self absorption of hematoma
4.3 function of promoting blood circulation to disperse blood clots
4.3.1 influence to normal hemorheology of rat
30 rats are selected in test for use, are divided into 3 groups at random, and 10 every group, male and female half and half.Every back part of animal is shaved hair, locates coating medicine-feeding 1 time in shaving hair every day by dosage shown in the table 5, successive administration 7 days, and the excipient group is coated with the excipient with volume outward.1h after the last administration, lumbar injection 0.8g/kg urethane anesthetized animal is cut abdominal part open, separates ventral aorta, and through abdominal aortic blood, the heparin sodium anticoagulant is measured whole blood viscosity with the LG-R-80C blood viscosity instrument and (is cut fast variability 200s
-1, 30s
-1, 5s
-1, 1s
-1); Centrifugal 2000r/min, about 10min, 2000 rev/mins of blood of residue are centrifugal, separated plasma, the viscosity of mensuration blood plasma.Each administration cell mean and excipient cell mean are compared, carry out statistics T test.Result's (seeing Table 3) shows that the lung-pulse ointment administration group can significantly reduce whole blood viscosity and plasma viscosity, shows that this medicine has significant function of promoting blood circulation to disperse blood clots.Of the present invention group of more former technology group therapeutical effect is good, and significant difference is arranged.
Table 3 the lung-pulse ointment is to the n=10 that influences of normal hemorheology of rat
| Grouping | Dosage (mg/kg) | Whole blood viscosity (mPa.s) | Plasma viscosity (mPa.s) | |
| 200S -1 | 5S -1 | |||
| Of the present invention group of the former technology group of excipient group | - 0.3 0.3 | 4.06±0.54 3.64±0.47 3.46±0.47 | 10.63±1.16 9.42±143 9.08±0.88 | 1.40±0.21 1.26±0.14 1.20±0.10 |
4.3.2 influence to the blood stasis model hemorheology of rat
40 rats are selected in test for use, are divided into 4 groups at random, and 10 every group, male and female half and half.Every back part of animal is shaved hair, locates coating medicine-feeding 1 time in shaving hair every day by dosage shown in the table 4, successive administration 7 days, and model group is coated with the excipient with volume outward.The animal fasting is 16 hours before the last administration, and after the last administration 30 minutes, except that matched group, all the other were respectively organized rat tail vein and inject 10% macromolecule right rotary glycoside solution 0.4ml/100g.After 30 minutes, the pentobarbital sodium anesthetized animal, abdominal aortic blood is put into the centrifuge tube that contains heparin sodium, shakes up, and gets the 0.8ml whole blood, inserts in the LG-R-80C type blood viscosity instrument (diligent generation Supreme Being's scientific instrument company limited in Beijing), and measuring and cutting speed is 200S
-1, 5S
-1The time viscosity.2000 rev/mins of blood of residue are centrifugal, and separated plasma is measured the viscosity of blood plasma, and measurement result is carried out statistical procedures.The result shows, behind the model group rat tail vein injection macromolecule right rotary glycoside, whole blood and plasma viscosity are apparently higher than matched group, and whole blood viscosity, the plasma viscosity of the lung-pulse ointment high dose group are markedly inferior to model group, show that the lung-pulse ointment can reduce the blood viscosity of blood stasis model rat very significantly, has the function of promoting blood circulation to disperse blood clots of highly significant.Of the present invention group of more former technology group therapeutical effect is good, and significant difference is arranged.
Table 4 the lung-pulse ointment is shown the n=10 that influences of blood stasis model hemorheology of rat
| Grouping | Dosage (mg/kg) | Whole blood viscosity (mPa.s) | Plasma viscosity (mPa.s) | |
| 200S -1 | 5S -1 | |||
| Of the present invention group of the former technology group of matched group model group | - - 0.3 0.3 | 2.97±0.20 4.75±0.51 3.93±0.36 3.55±0.48 | 7.55±0.59 12.17±0.62 11.46±1.86 8.96±1.25 | 1.22±0.06 1.83±0.20 1.46±0.15 1.38±0.11 |
4.4 to the bullate influence of Fructus Crotonis oiliness mouse ear (antiinflammatory action)
50 male mices are selected in test for use, are divided into 5 groups at random, 10 every group.Press dosage shown in the table 11 every day once in Mus ear coating medicine-feeding, successive administration 3 days, the excipient group gives with the volume excipient.After the last administration, 2% Oleum Tiglii proinflammatory agent 0.05ml dripped in every mouse right ear shell cause inflammation.Take off neck after causing scorching 2 hours and put to death mice, cut left and right ear, lay same position auricle, weigh with diameter 9mm card punch, with the difference of two ear weight as Mus dropsy of ear degree.Get each administration cell mean and excipient cell mean relatively, carry out statistics t test, result's (seeing Table 5) shows, each dosage group of the lung-pulse ointment has the inhibitory action of highly significant to the Mus ear swelling, particularly in dosage group effect more remarkable.Former dosage form also has significant inhibitory effect.Of the present invention group of more former technology group therapeutical effect is good, and significant difference is arranged.
Table 5 the lung-pulse ointment is to the bullate influence of mouse ear
The specific embodiment
Further specify technology of the present invention below by specific embodiment:
Embodiment 1:
Raw material: Rhizoma Curcumae Longae 16g, Semen Myristicae 4g, Radix Et Rhizoma Nardostachyos 8g, Actinolitum 4g, Radix Glycyrrhizae 6g, Moschus 0.06g, Rhizoma Zingiberis 10g, Fructus cari carvi 13g, Rhizoma Acori Calami 6g, Pericarpium Zanthoxyli 4g, trona 7g.
Preparation technology:
1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
2. take by weighing 10% of mixed powder gross weight, decoct with water 4 times, collect volatile oil simultaneously, each water yield that adds is 5 times of medical material gross weight, and 100 ℃ of temperature were fried in shallow oil 3 hours at every turn, collected decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.3 concentrated solution, and is standby;
3. will remain and mix with above-mentioned concentrated medicament, 56g Tween-80,320g glycerol after medicated powder (90%) is ground into the medicated powder of 0.01～200 μ m, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ standby;
4. get the 110g liquid paraffin, be warming up to 75 ℃ after, join in the admixing medical solutions, stir; Adding the 50g PEG400, is to stir 40 minutes fast in the condition underlying homogenizer of 0.08MPa keeping vacuum pressure then, treats that temperature reduces to 30 ℃, adds Moschus, promptly can be made into ointment after stirring.
Embodiment 2:
Raw material: Rhizoma Curcumae Longae 20g, Semen Myristicae 8g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 8g, Radix Glycyrrhizae 10g, artificial Moschus 0.1g, Rhizoma Kaempferiae 14g, Fructus cari carvi 19g, Rhizoma Acori Calami 10g, Pericarpium Zanthoxyli 8g, trona 11g.
1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
2. take by weighing 15% of mixed powder gross weight, decoct with water 3 times, collect volatile oil simultaneously, each water yield that adds is 10 times of medical material gross weight, and 70 ℃ of temperature each 2 hours, are collected decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.1 concentrated solution, and is standby;
3. after above-mentioned remaining medicated powder (85%) being ground into the medicated powder of 0.01～200 μ m,, stir, obtain the mixed liquor of medicinal liquid and water with concentrated solution, 370g hexadecanol, 480g mixed with propylene glycol, be warming up to 95 ℃ standby;
4. get the 1400g Cera Flava, be warming up to 95 ℃, in the mixed liquor in joining 3., add the 20g sodium benzoate and stirred 30 minutes, treat that temperature reduces to 30 ℃, add the artificial Moschus, promptly can be made into ointment after stirring.
Embodiment 3:
Raw material: Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, Moschus 0.08g, Rhizoma Kaempferiae 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g.
1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
2. take by weighing 30% of mixed powder gross weight, decoct with water 2 times, collect volatile oil simultaneously, each water yield that adds is 15 times of medical material gross weight, and 95 ℃ of temperature were fried in shallow oil 1 hour at every turn, collected decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.2 concentrated solution, and is standby.
3. will remain the medicated powder that medicated powder (70%) is ground into 0.01～200 μ m and mix, stir, obtain the mixed liquor of medicinal liquid and water with concentrated medicament, 45g tristerin, 120g water, 80g glycerol, be warming up to 80 ℃ standby;
4. getting 110g vaseline, add 3. gained mixed liquor when being warming up to 80 ℃, stir, is to place in the homogenizer under the condition of 0.01MPa to stir 20 minutes fast keeping vacuum pressure, treats that temperature reduces to 30 ℃, adds and promptly makes ointment after Moschus stirs.
Embodiment 4:
Raw material: Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g.
1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized, mix homogeneously, standby;
2. take by weighing 50% of mixed powder gross weight, decoct with water 1 time, collect volatile oil simultaneously, amount of water is 20 times of medical material gross weight, and 80 ℃ of temperature were fried in shallow oil 1.5 hours, collects decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.0 concentrated solution, and is standby.
3. will remain medicated powder (50%) be ground into the medicated powder of 0.01～200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ standby;
4. get the 100g lanoline, gained mixed liquor in adding 3. when being warming up to 75 ℃ stirs, and is to place in the homogenizer under the condition of 0.09MPa to stir 20 minutes fast keeping vacuum pressure, treat that temperature reduces to 30 ℃, add and promptly make ointment after the artificial Moschus stirs.
Embodiment 5:
Raw material: Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g.
1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
2. take by weighing 60% of mixed powder gross weight, decoct with water 2 times, collect volatile oil simultaneously, each water yield that adds is 10 times of medical material gross weight, and 75 ℃ of temperature were fried in shallow oil 0.5 hour at every turn, collected decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.3 concentrated solution, and is standby.
3. will remain medicated powder (40%) be ground into the medicated powder of 0.01～200 μ m after, mix with concentrated medicament, 45g octadecanol, 200g water, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ standby;
4. get 100g lanoline, 10g glyceryl monostearate, add 3. middle gained mixed liquor when the 10g sodium propionate is warming up to 75 ℃, stir, the condition underlying homogenizer internal emulsification that keeps vacuum 5 minutes, treat that temperature reduces to 30 ℃, add and promptly make ointment after the artificial Moschus stirs.
Embodiment 6:
Raw material: Rhizoma Curcumae Longae 16g, Semen Myristicae 4g, Radix Et Rhizoma Nardostachyos 8g, Actinolitum 4g, Radix Glycyrrhizae 6g, Moschus 0.06g, Rhizoma Zingiberis 10g, Fructus cari carvi 13g, Rhizoma Acori Calami 6g, Pericarpium Zanthoxyli 4g, trona 7g.
1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
2. take by weighing 90% of mixed powder gross weight, decoct with water 2 times, collect volatile oil simultaneously, each water yield that adds is 10 times of medical material gross weight, and 95 ℃ of temperature were fried in shallow oil 2 hours at every turn, collected decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.4 concentrated solution, and is standby.
3. after remaining 10% medicated powder being ground into the medicated powder of 0.01～200 μ m, mix, stir, obtain the mixed liquor of medicinal liquid and water with concentrated medicament, 56g triethanolamine, 320g glycerol, be warming up to 90 ℃ standby;
4. get the 110g liquid paraffin, be warming up to 90 ℃, gained mixed liquor in joining 3. stirs, and is the condition underlying homogenizer internal emulsification 1 minute of 0.05MPa keeping vacuum pressure, treats that temperature reduces to 30 ℃, adds and promptly makes ointment after Moschus stirs.
Embodiment 7:
Raw material: Rhizoma Curcumae Longae 20g, Semen Myristicae 8g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 8g, Radix Glycyrrhizae 10g, artificial Moschus 0.1g, Rhizoma Kaempferiae 14g, Fructus cari carvi 19g, Rhizoma Acori Calami 10g, Pericarpium Zanthoxyli 8g, trona 11g.
1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
2. take by weighing 40% of mixed powder gross weight, decoct with water 2 times, collect volatile oil simultaneously, each amount of water is 15 times of medical material gross weight, and 70 ℃ of temperature were fried in shallow oil 1.5 hours at every turn, collected decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.2 concentrated solution, and is standby.
3. after remaining 60% medicated powder being ground into the medicated powder of 0.01～200 μ m,, stir, obtain the mixed liquor of medicinal liquid and water with concentrated medicament, 370g octadecanol, 480g mixed with propylene glycol, be warming up to 75 ℃ standby;
4. get the 1400g Cera Flava, join 3. middle gained mixed liquor when being warming up to 75 ℃, add the 50g hydroxyethyl-cellulose, stir, keeping vacuum pressure is the condition underlying homogenizer internal emulsification 15 minutes of 0.06MPa, treats that temperature reduces to 30 ℃, adds and promptly makes ointment after the artificial Moschus stirs.
Embodiment 8:
Raw material: Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g.
1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
2. take by weighing 95% of mixed powder gross weight, decoct with water 1 time, collect volatile oil simultaneously, the water yield of adding is 20 times of medical material gross weight, and 75 ℃ of temperature were fried in shallow oil 3 hours, collects decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.5 concentrated solution, and is standby.
3. after remaining 5% medicated powder being ground into the medicated powder of 0.01～200 μ m,, 120g water smooth with concentrated medicament, 45g fatty acid Pyrusussuriensis, 80g glycerol mix, and stir, and obtain the mixed liquor of medicinal liquid and water, be warming up to 85 ℃ standby;
4. get 110g vaseline, be warming up to 85 ℃, gained mixed liquor in joining 3. stirs, and is the condition underlying homogenizer internal emulsification 8 minutes of 0.03MPa keeping vacuum pressure, treats that temperature reduces to 30 ℃, adds Moschus, promptly makes ointment after stirring.
Embodiment 9:
Raw material: Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g.
1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
2. take by weighing 80% of mixed powder gross weight, decoct with water 1 time, collect volatile oil simultaneously, the water yield of adding is 5 times of medical material gross weight, and 80 ℃ of temperature were fried in shallow oil 1 hour, collects decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.2 concentrated solution, and is standby.
3. after remaining 20% medicated powder being ground into the medicated powder of 0.01～200 μ m, mix, stir, obtain the mixed liquor of medicinal liquid and water with concentrated medicament, 45g sodium lauryl sulfate, 200g water, be warming up to 95 ℃ standby;
4. get 100 lanolines, be warming up to 95 ℃, join 3. middle gained mixed liquor, adding the 30g sorbic acid stirs, keeping vacuum pressure is the condition underlying homogenizer internal emulsification 12 minutes of 0.02MPa, treats that temperature reduces to 30 ℃, adds and promptly makes ointment after the artificial Moschus stirs.
Embodiment 10:
Raw material: Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, Moschus 0.08g, Rhizoma Kaempferiae 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g.
1. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
2. take by weighing 50% of mixed powder gross weight, decoct with water 3 times, collect volatile oil simultaneously, each water yield that adds is 10 times of medical material gross weight, and 70 ℃ of temperature were fried in shallow oil 0.5 hour at every turn, collected decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.3 concentrated solution, and is standby.
3. remaining 50% medicated powder, concentrated medicament, 45g sodium lauryl sulfate, 200g water are mixed, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 70 ℃ standby;
4. treating the 100g lanoline, stir in the gained mixed liquor in adding 3. when being warming up to 70 ℃, is the condition underlying homogenizer internal emulsification 18 minutes of 0.07MPa keeping vacuum pressure, treats that temperature reduces to 30 ℃, adds Moschus, promptly makes ointment after stirring.
Embodiment 11:
Raw material: Rhizoma Curcumae Longae 16g, Semen Myristicae 4g, Radix Et Rhizoma Nardostachyos 8g, Actinolitum 4g, Radix Glycyrrhizae 6g, artificial Moschus 0.06g, Rhizoma Zingiberis 10g, Fructus cari carvi 13g, Rhizoma Acori Calami 6g, Pericarpium Zanthoxyli 4g, trona 7g.
1. artificial Moschus 0.06g is added 1.2g water and grind, cross 80～200 mesh sieves, standby;
2. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
3. with mixed powder, decoct with water 3 times, collect volatile oil simultaneously, each water yield that adds is 10 times of medical material gross weight, and 85 ℃ of temperature were fried in shallow oil 2 hours at every turn, collected decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.1 concentrated solution, and is standby.
4. concentrated medicament is mixed with 56g triethanolamine, 320g glycerol, stirs, obtain the mixed liquor of medicinal liquid and water, be warming up to 85 ℃ standby;
5. get the 110g liquid paraffin, be warming up to 85 ℃, gained mixed liquor in joining 4. stirs, and is the condition underlying homogenizer internal emulsification 3 minutes of 0.06MPa keeping vacuum pressure, treats that temperature reduces to 30 ℃, adds and promptly makes ointment after the artificial Moschus stirs.
Embodiment 12:
Raw material: Rhizoma Curcumae Longae 20g, Semen Myristicae 8g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 8g, Radix Glycyrrhizae 10g, Moschus 0.1g, Rhizoma Kaempferiae 14g, Fructus cari carvi 19g, Rhizoma Acori Calami 10g, Pericarpium Zanthoxyli 8g, trona 11g.
1. Moschus 0.1g is added 3g water and grind, cross 80～200 mesh sieves, standby;
2. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
3. mixed powder is decocted with water 2 times, collect volatile oil simultaneously, each amount of water is 15 times of medical material gross weight, and 90 ℃ of temperature were fried in shallow oil 1.5 hours at every turn, collected decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.1 concentrated solution, and is standby.
4. with concentrated medicament and 370g octadecanol, 480g mixed with propylene glycol, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ standby;
5. get the 1400g Cera Flava, be warming up to 75 ℃ join 4. in the gained mixed liquor, stirred fast 40 minutes, treat that temperature reduces to 30 ℃, add and promptly make ointment after Moschus stirs.
Embodiment 13:
Raw material: Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g.
1. artificial Moschus 0.06g is added 0.3g water and grind, cross 80～200 mesh sieves, standby;
2. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
3. mixed powder is decocted with water 4 times, collect volatile oil simultaneously, each water yield that adds is 20 times of medical material gross weight, and 80 ℃ of temperature were fried in shallow oil 3 hours at every turn, collected decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.1 concentrated solution, and is standby.
4. concentrated medicament is smooth with 45g fatty acid Pyrusussuriensis, 120g water, 80g glycerol mix, and stir, and obtain the mixed liquor of medicinal liquid and water, be warming up to 95 ℃ standby.
5. get 110g vaseline, when being warming up to 95 ℃, join 4. middle gained mixed liquor, stir, keeping vacuum pressure is the condition underlying homogenizer internal emulsification 1 minute of 0.07MPa, treats to add the artificial Moschus when temperature is reduced to 30 ℃, promptly makes ointment after stirring.
Embodiment 14:
Raw material: Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, Moschus 0.08g, Rhizoma Kaempferiae 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g.
1. Moschus 0.08g is added 2g water and grind, cross 80～200 mesh sieves, standby;
2. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
3. mixed powder is decocted with water 1 time, collect volatile oil simultaneously, amount of water is 5 times of medical material gross weight, and 95 ℃ of temperature decocted 1 hour, collects decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.1 concentrated solution, and is standby.
4. concentrated medicament is mixed with 45g sodium lauryl sulfate, 200g water, stirs, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ standby;
5. taking by weighing the 100g lanoline, be warming up to 75 ℃ and stir in the gained mixed liquor in joining 4., is the condition underlying homogenizer internal emulsification 20 minutes of 0.04MPa keeping vacuum pressure, treats that temperature reduces to 30 ℃, adds and promptly makes ointment after Moschus stirs.
Embodiment 15:
Raw material: Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g.
1. artificial Moschus 0.08g is added 2g water and grind, cross 80～200 mesh sieves, standby;
2. Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona are made only, pulverized the back mix homogeneously, standby;
3. with mixed powder, decoct with water 3 times, collect volatile oil simultaneously, each amount of water is 10 times of medical material gross weight, and 85 ℃ of temperature were fried in shallow oil 0.5 hour at every turn, collected decocting liquid; Collecting decoction and volatile oil filter, and are condensed into proportion and are 1.4 concentrated solution, and is standby.
4. concentrated medicament mixes with 45g sodium lauryl sulfate, 200g water, stirs, and obtains the mixed liquor of medicinal liquid and water, be warming up to 85 ℃ standby;
5. take by weighing the 100g lanoline, be warming up to 85 ℃ join 4. in the gained mixed liquor, stir, be the condition underlying homogenizer internal emulsification 15 minutes of 0.05MPa keeping vacuum pressure, treat that temperature reduces to 30 ℃, add and promptly make ointment after the artificial Moschus stirs.
Embodiment 16:
Raw material: Rhizoma Curcumae Longae 16g, Semen Myristicae 4g, Radix Et Rhizoma Nardostachyos 8g, Actinolitum 4g, Radix Glycyrrhizae 6g, Moschus 0.06g, Rhizoma Zingiberis 10g, Fructus cari carvi 13g, Rhizoma Acori Calami 6g, Pericarpium Zanthoxyli 4g, trona 7g.
1. Moschus 0.06g is added 1.2g water and grind, cross 80～200 mesh sieves, standby;
2. add water after Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona being made only, the water yield that is added is 5 times of medical material gross weight, carried out extracting the first time 24 hours in that 95 ℃ temperature are following, filter, obtain for the first time volatile oil, extracting solution and medicinal residues for the first time for the first time;
3. for the first time medicinal residues extracted 10 hours down at 70 ℃ with 3 times water of medical material gross weight, filtered, and obtained for the second time volatile oil, extracting solution and medicinal residues for the second time for the second time;
4. for the second time medicinal residues extracted 6 hours down at 70 ℃ with 3 times water of medical material gross weight, filtered, and obtained for the third time volatile oil, extracting solution and medicinal residues for the third time for the third time;
5. merge three volatile oil and three extracting solution that obtain; The relative density that is concentrated into medicinal liquid is 1.2, obtains concentrated solution;
6. concentrated medicament mixes with 56g triethanolamine, 320g glycerol, stirs, and obtains the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ standby;
7. take by weighing the 110g liquid paraffin, be warming up to 75 ℃ and join in the above-mentioned mixed liquor, stirred fast 10 minutes, treat that temperature reduces to 30 ℃, add and promptly make ointment after Moschus stirs.
Embodiment 17:
Raw material: Rhizoma Curcumae Longae 20g, Semen Myristicae 8g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 8g, Radix Glycyrrhizae 10g, Moschus 0.1g, Rhizoma Kaempferiae 14g, Fructus cari carvi 19g, Rhizoma Acori Calami 10g, Pericarpium Zanthoxyli 8g, trona 11g.
1. Moschus 0.1g is added 3g water and grind, cross 80～200 mesh sieves, standby;
2. add water after Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona being made only, the water yield that is added is 20 times of medical material gross weight, carried out extracting the first time 0.5 hour in that 90 ℃ temperature are following, filter, obtain for the first time volatile oil, extracting solution and medicinal residues for the first time for the first time;
3. for the first time medicinal residues extracted 0.5 hour down at 70 ℃ with 15 times water of medical material gross weight, filtered, and obtained for the second time volatile oil, extracting solution and medicinal residues for the second time for the second time;
4. for the second time medicinal residues extracted 0.5 hour down at 70 ℃ with 10 times water of medical material gross weight, filtered, and obtained for the third time volatile oil, extracting solution and medicinal residues for the third time for the third time;
5. merge three volatile oil and three extracting solution that obtain; The relative density that is concentrated into medicinal liquid is 1.0, obtains concentrated solution;
6. with concentrated medicament and 370g octadecanol, 480g mixed with propylene glycol, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 95 ℃ standby;
7. taking by weighing the 1400g Cera Flava, be warming up to 95 ℃ and join in the above-mentioned mixed liquor, stir, is the condition underlying homogenizer internal emulsification 5 minutes of 0.03MPa keeping vacuum pressure, treats that temperature reduces to 30 ℃, adds and promptly makes ointment after Moschus stirs.
Embodiment 18:
Raw material: Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, Moschus 0.08g, Rhizoma Kaempferiae 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g.
1. Moschus 0.06g is added 0.3g water and grind, cross 80～200 mesh sieves, standby;
2. add water after Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona being made only, the water yield that is added is 10 times of medical material gross weight, carried out extracting the first time 10 hours in that 95 ℃ temperature are following, filter, obtain for the first time volatile oil, extracting solution and medicinal residues for the first time for the first time;
3. for the first time medicinal residues extracted 5 hours down at 80 ℃ with 8 times water of medical material gross weight, filtered, and obtained for the second time volatile oil, extracting solution and medicinal residues for the second time for the second time;
4. for the second time medicinal residues extracted 3 hours down at 80 ℃ with 6 times water of medical material gross weight, filtered, and obtained for the third time volatile oil, extracting solution and medicinal residues for the third time for the third time;
5. merge three volatile oil and three extracting solution that obtain; The relative density that is concentrated into medicinal liquid is 1.5, obtains concentrated solution;
6. concentrated medicament is mixed with 45g carbomer, 120g water, 80g glycerol, stirs, obtain the mixed liquor of medicinal liquid and water, be warming up to 85 ℃ standby;
7. taking by weighing 110g vaseline, be warming up to 85 ℃, join in the above-mentioned mixed liquor, stir, is the condition underlying homogenizer internal emulsification 12 minutes of 0.09MPa keeping vacuum pressure, treats that temperature reduces to 30 ℃, adds and promptly makes ointment after Moschus stirs.
Embodiment 19:
Raw material: Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Zingiberis 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g.
1. artificial Moschus 0.08g is added 2g water and grind, cross 80～200 mesh sieves, standby;
2. add water after Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona being made only, the water yield that is added is 15 times of medical material gross weight, carried out extracting the first time 12 hours in that 90 ℃ temperature are following, filter, obtain for the first time volatile oil, extracting solution and medicinal residues for the first time for the first time;
3. for the first time medicinal residues extracted 8 hours down at 90 ℃ with 12 times water of medical material gross weight, filtered, and obtained for the second time volatile oil, extracting solution and medicinal residues for the second time for the second time;
4. for the second time medicinal residues extracted 4 hours down at 70 ℃ with 8 times water of medical material gross weight, filtered, and obtained for the third time volatile oil, extracting solution and medicinal residues for the third time for the third time;
5. merge three volatile oil and three extracting solution that obtain; The relative density that is concentrated into medicinal liquid is 1.3, obtains concentrated solution;
6. concentrated medicament is mixed with 45g sodium lauryl sulfate, 200g water, stirs, obtain the mixed liquor of medicinal liquid and water, be warming up to 95 ℃ standby;
7. take by weighing the 100g lanoline, be warming up to 95 ℃, join in the above-mentioned mixed liquor, stirring, is the condition underlying homogenizer internal emulsification 10 minutes of 0.09MPa keeping vacuum pressure, treats that temperature reduces to 30 ℃, add above-mentioned artificial Moschus, promptly make ointment after stirring.
Embodiment 20:
Raw material: Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, Moschus 0.08g, Rhizoma Kaempferiae 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g.
1. Moschus 0.08g is added 2g water and grind, cross 80～200 mesh sieves, standby;
2. add water after Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona being made only, the water yield that is added is 8 times of medical material gross weight, carried out extracting the first time 5 hours in that 75 ℃ temperature are following, filter, obtain for the first time volatile oil, extracting solution and medicinal residues for the first time for the first time;
3. for the first time medicinal residues extracted 2 hours down at 70 ℃ with 6 times water of medical material gross weight, filtered, and obtained for the second time volatile oil, extracting solution and medicinal residues for the second time for the second time;
4. for the second time medicinal residues extracted 1 hour down at 70 ℃ with 4 times water of medical material gross weight, filtered, and obtained for the third time volatile oil, extracting solution and medicinal residues for the third time for the third time;
5. merge three volatile oil and three extracting solution that obtain; The relative density that is concentrated into medicinal liquid is 1.3, obtains concentrated solution;
6. concentrated medicament is mixed with 45g sodium lauryl sulfate, 200g water, stirs, obtain the mixed liquor of medicinal liquid and water, be warming up to 80 ℃ standby;
7. take by weighing the 100g lanoline, temperature rises to 80 ℃, join in the above-mentioned mixed liquor to stir, and be the condition underlying homogenizer internal emulsification 8 minutes of 0.01MPa keeping vacuum pressure, treat that temperature reduces to 30 ℃, add and promptly make ointment after Moschus stirs.
Embodiment 21:
Raw material: Rhizoma Curcumae Longae 18g, Semen Myristicae 6g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 6g, Radix Glycyrrhizae 8g, artificial Moschus 0.08g, Rhizoma Kaempferiae 12g, Fructus cari carvi 16g, Rhizoma Acori Calami 8g, Pericarpium Zanthoxyli 6g, trona 9g.
1. artificial Moschus 0.08g is added 2g water and grind, cross 80～200 mesh sieves, standby;
2. add water after Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona being made only, the water yield that is added is 8 times of medical material gross weight, carried out extracting the first time 5 hours in that 85 ℃ temperature are following, filter, obtain for the first time volatile oil, extracting solution and medicinal residues for the first time for the first time;
3. for the first time medicinal residues extracted 2 hours down at 75 ℃ with 6 times water of medical material gross weight, filtered, and obtained for the second time volatile oil, extracting solution and medicinal residues for the second time for the second time;
4. for the second time medicinal residues extracted 1 hour down at 75 ℃ with 4 times water of medical material gross weight, filtered, and obtained for the third time volatile oil, extracting solution and medicinal residues for the third time for the third time;
5. merge three volatile oil and three extracting solution that obtain; The relative density that is concentrated into medicinal liquid is 1.3, obtains concentrated solution;
6. concentrated medicament is mixed with 45g sodium lauryl sulfate, 200g water, stirs, obtain the mixed liquor of medicinal liquid and water, be warming up to 75 ℃ standby;
7. taking by weighing the 100g lanoline, be warming up to 75 ℃, join in the above-mentioned mixed liquor and stir, is to place the homogenizer internal emulsification 12 minutes under the condition of 0.06MPa keeping vacuum pressure, treats that temperature reduces to 30 ℃, adds and promptly makes ointment after the artificial Moschus stirs.
Embodiment 22:
Raw material: Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g.
1. Moschus 0.17g is added 1.7g water and grind, cross 80～200 mesh sieves, standby;
2. add water after Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona being made only, the water yield that is added is 10 times of medical material gross weight, carried out extracting the first time 1.5 hours in that 95 ℃ temperature are following, filter, obtain for the first time volatile oil, extracting solution and medicinal residues for the first time for the first time;
3. for the first time medicinal residues extracted 1 hour down at 95 ℃ with 8 times water of medical material gross weight, filtered, and obtained for the second time volatile oil, extracting solution and medicinal residues for the second time for the second time;
4. for the second time medicinal residues extracted 0.5 hour down at 95 ℃ with 6 times water of medical material gross weight, filtered, and obtained for the third time volatile oil, extracting solution and medicinal residues for the third time for the third time;
5. merge three volatile oil and three extracting solution that obtain; The relative density that is concentrated into medicinal liquid is 1.2, obtains concentrated solution;
6. concentrated medicament is mixed with 90g Tween-80,80g glycerol, stir, obtain the mixed liquor of medicinal liquid and water, standby when being warming up to 95 ℃;
7. with 80g liquid paraffin and 2g methyl hydroxybenzoate mix homogeneously, obtain the oil phase mixed liquor;
8. treating that the oil phase mixeding liquid temperature rises to 95 ℃, stir in adding 6., is to place the homogenizer internal emulsification 10 minutes under the condition of 0.05MPa keeping vacuum pressure, and temperature is reduced to 30 ℃, adds promptly to make ointment after Moschus stirs.
Embodiment 23:
Raw material: Rhizoma Curcumae Longae 20g, Semen Myristicae 8g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 8g, Radix Glycyrrhizae 10g, artificial Moschus 0.1g, Rhizoma Kaempferiae 14g, Fructus cari carvi 19g, Rhizoma Acori Calami 10g, Pericarpium Zanthoxyli 8g, trona 11g.
1. artificial Moschus 0.1g is added 1.0g water and grind, cross 80～200 mesh sieves, standby;
2. add water after Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona being made only, the water yield that is added is 15 times of medical material gross weight, carried out extracting the first time 2 hours in that 70 ℃ temperature are following, filter, obtain for the first time volatile oil, extracting solution and medicinal residues for the first time for the first time;
3. for the first time medicinal residues extracted 1.5 hours down at 70 ℃ with 10 times water of medical material gross weight, filtered, and obtained for the second time volatile oil, extracting solution and medicinal residues for the second time for the second time;
4. for the second time medicinal residues extracted 1 hour down at 70 ℃ with 8 times water of medical material gross weight, filtered, and obtained for the third time volatile oil, extracting solution and medicinal residues for the third time for the third time;
5. merge three volatile oil and three extracting solution that obtain; The relative density that is concentrated into medicinal liquid is 1.5, obtains concentrated solution;
6. with concentrated medicament and 370g octadecanol, 480g mixed with propylene glycol, stir, obtain the mixed liquor of medicinal liquid and water, be warming up to 85 ℃ standby;
7. taking by weighing the 1400g Cera Flava, be warming up to 85 ℃, join in the above-mentioned mixed liquor and stir, is to place in the homogenizer under the condition of 0.09MPa to stir 10 minutes keeping vacuum pressure, is cooled to 30 ℃, adds and promptly makes ointment after the artificial Moschus stirs.
Embodiment 24:
Raw material: Rhizoma Curcumae Longae 16g, Semen Myristicae 4g, Radix Et Rhizoma Nardostachyos 8g, Actinolitum 4g, Radix Glycyrrhizae 6g, artificial Moschus 0.06g, Rhizoma Kaempferiae 10g, Fructus cari carvi 13g, Rhizoma Acori Calami 6g, Pericarpium Zanthoxyli 4g, trona 7g.
1. artificial Moschus 0.06g is added 0.6g water and grind, cross 80～200 mesh sieves, standby;
2. add water after Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona being made only, the water yield that is added is 18 times of medical material gross weight, carried out extracting the first time 3 hours in that 90 ℃ temperature are following, filter, obtain for the first time volatile oil, extracting solution and medicinal residues for the first time for the first time;
3. for the first time medicinal residues extracted 2 hours down at 90 ℃ with 12 times water of medical material gross weight, filtered, and obtained for the second time volatile oil, extracting solution and medicinal residues for the second time for the second time;
4. for the second time medicinal residues extracted 1 hour down at 90 ℃ with 5 times water of medical material gross weight, filtered, and obtained for the third time volatile oil, extracting solution and medicinal residues for the third time for the third time;
5. merge three volatile oil and three extracting solution that obtain; The relative density that is concentrated into medicinal liquid is 1.3, obtains concentrated solution;
6. concentrated medicament is mixed with 56g triethanolamine, 320g glycerol, stirs, obtain the mixed liquor of medicinal liquid and water, be warming up to 90 ℃ standby;
7. taking by weighing the 110g liquid paraffin, be warming up to 90 ℃, join in the above-mentioned mixed liquor and stir, is to place the homogenizer internal emulsification after 12 minutes under the condition of 0.09MPa keeping vacuum pressure, is cooled to 30 ℃, adds and promptly makes ointment after the artificial Moschus stirs.
Embodiment 25:
Raw material: Rhizoma Curcumae Longae 36.3g, Semen Myristicae 12.1g, Radix Et Rhizoma Nardostachyos 19.4g, Actinolitum 12.1g, Radix Glycyrrhizae 17.0g, Moschus 0.17g, Rhizoma Zingiberis 24.2g, Fructus cari carvi 31.5g, Rhizoma Acori Calami 17.0g, Pericarpium Zanthoxyli 12.1g, trona 18.2g.
1. Moschus 0.17g is added 1.7g water and grind, cross 80～200 mesh sieves, standby;
2. add water after Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona being made only, the water yield that is added is 10 times of medical material gross weight, carried out extracting the first time 1.5 hours in that 90 ℃ temperature are following, filter, obtain for the first time volatile oil, extracting solution and medicinal residues for the first time for the first time;
3. for the first time medicinal residues extracted 1 hour down at 90 ℃ with 8 times water of medical material gross weight, filtered, and obtained for the second time volatile oil, extracting solution and medicinal residues for the second time for the second time;
4. for the second time medicinal residues extracted 0.5 hour down at 90 ℃ with 6 times water of medical material gross weight, filtered, and obtained for the third time volatile oil, extracting solution and medicinal residues for the third time for the third time;
5. merge three volatile oil and three extracting solution that obtain; The relative density that is concentrated into medicinal liquid is 1.1, obtains concentrated solution;
6. concentrated medicament is mixed with 90g Tween-80,80g glycerol, stirs, obtain the mixed liquor of medicinal liquid and water, be warming up to 90 ℃ standby;
7. with 80g liquid paraffin and 2g methyl hydroxybenzoate mix homogeneously, obtain the oil phase mixed liquor;
8. treating that the oil phase mixeding liquid temperature rises to 90 ℃, join in the above-mentioned water mixed liquor and stir, is to place the homogenizer internal emulsification after 10 minutes under the condition of 0.09MPa keeping vacuum pressure, is cooled to 30 ℃, adds and promptly makes ointment after Moschus stirs.
Embodiment 26:
Raw material: Rhizoma Curcumae Longae 16g, Semen Myristicae 4g, Radix Et Rhizoma Nardostachyos 8g, Actinolitum 4g, Radix Glycyrrhizae 6g, artificial Moschus 0.06g, Rhizoma Kaempferiae 10g, Fructus cari carvi 13g, Rhizoma Acori Calami 6g, Pericarpium Zanthoxyli 4g, trona 7g.
1. artificial Moschus 0.06g is added 1.2g water and grind, cross 80～200 mesh sieves, standby;
2. add water after Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Kaempferiae, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona being made only, the water yield that is added is 20 times of medical material gross weight, carried out extracting the first time 1 hour in that 75 ℃ temperature are following, filter, obtain for the first time volatile oil, extracting solution and medicinal residues for the first time for the first time;
3. for the first time medicinal residues extracted 1 hour down at 75 ℃ with 15 times water of medical material gross weight, filtered, and obtained for the second time volatile oil, extracting solution and medicinal residues for the second time for the second time;
4. for the second time medicinal residues extracted 0.5 hour down at 75 ℃ with 10 times water of medical material gross weight, filtered, and obtained for the third time volatile oil, extracting solution and medicinal residues for the third time for the third time;
5. merge three volatile oil and three extracting solution that obtain; The relative density that is concentrated into medicinal liquid is 1.4, obtains concentrated solution;
6. concentrated medicament is mixed with 56g triethanolamine, 320g glycerol, the 5g carbomer stirs, and obtains the mixed liquor of medicinal liquid and water, be warming up to 95 ℃ standby;
7. taking by weighing the 110g liquid paraffin, be warming up to 95 ℃, join in the mixed liquor and stir, is to place in the homogenizer under the condition of 0.07MPa to stir 20 minutes keeping vacuum pressure, is cooled to 30 ℃, adds and promptly makes ointment after the artificial Moschus stirs.
Embodiment 27:
Raw material: Rhizoma Curcumae Longae 20g, Semen Myristicae 8g, Radix Et Rhizoma Nardostachyos 12g, Actinolitum 8g, Radix Glycyrrhizae 10g, artificial Moschus 0.1g, Rhizoma Zingiberis 14g, Fructus cari carvi 19g, Rhizoma Acori Calami 10g, Pericarpium Zanthoxyli 8g, trona 11g.
1. artificial Moschus 0.1g is added 1.5g water and grind, cross 80～200 mesh sieves, standby;
2. add water after Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona being made only, the water yield that is added is 18 times of medical material gross weight, carried out extracting the first time 1.5 hours in that 70 ℃ temperature are following, filter, obtain for the first time volatile oil, extracting solution and medicinal residues for the first time for the first time;
3. for the first time medicinal residues extracted 1 hour down at 70 ℃ with 12 times water of medical material gross weight, filtered, and obtained for the second time volatile oil, extracting solution and medicinal residues for the second time for the second time;
4. for the second time medicinal residues extracted 0.5 hour down at 70 ℃ with 8 times water of medical material gross weight, filtered, and obtained for the third time volatile oil, extracting solution and medicinal residues for the third time for the third time;
5. merge three volatile oil and three extracting solution that obtain; The relative density that is concentrated into medicinal liquid is 1.2, obtains concentrated solution;
6. concentrated medicament is mixed with 200g carbomer, 20g triethanolamine, 200g propylene glycol and 660g water, stir, add and promptly make ointment after the artificial Moschus stirs.
Claims (10)
1. the water of a lung-pulse ointment is obtained through refining Preparation Method, is formed by following crude drug and prepared:
Crude drug prescription: by weight
Rhizoma Curcumae Longae 16～20%, Semen Myristicae 4～8%, Radix Et Rhizoma Nardostachyos 8～12%, Actinolitum 4～8%, Radix Glycyrrhizae 6～10%, artificial Moschus or Moschus 0.06～0.1%, Rhizoma Zingiberis 10～14%, Fructus cari carvi 13～19%, Rhizoma Acori Calami 6～10%, Pericarpium Zanthoxyli 4～8%, trona 7～11%;
Preparation technology:
1. with Rhizoma Curcumae Longae, Semen Myristicae, Radix Et Rhizoma Nardostachyos, Actinolitum, Radix Glycyrrhizae, Rhizoma Zingiberis, Fructus cari carvi, Rhizoma Acori Calami, Pericarpium Zanthoxyli, trona remove impurity, clean system, mixing;
2. take by weighing above-mentioned hybrid medicine total amount 10%～100%,, decoct 1～4 time down, fried in shallow oil collection, merge extractive liquid, and volatile oil at every turn 0.5～3 hour in 70～100 ℃ with 5～20 times of water of medicine gross weight; Filter concentrated extracting solution; Volatile oil joins and extracts in the concentrated solution, gets concentrated solution;
3. will remain the medicated powder that hybrid medicine is ground into 0.01～200 μ m, and mix, obtain mixed liquor a with above-mentioned concentrated solution; Add the water of 1～100 times of mixed liquor a weight then, stir, obtain mixed liquor b;
4. with mixed liquor b and oil phase and emulsifying agent with 100: 0: 1～100: 95: 100 weight ratio mix, emulsifying gets emulsifying ointment;
5. Moschus or the artificial Moschus with formula ratio joins in the above-mentioned emulsifying ointment, stirs; Or earlier the artificial Moschus of formula ratio or the Moschus water with 2～30 times of weight portions is ground, behind mistake 60～200 mesh sieves, joining stirs in the above-mentioned emulsifying ointment again gets final product.
2. the water of the lung-pulse ointment is obtained through refining Preparation Method according to claim 1, it is characterized in that: it is 1.0～1.5 concentrated solution that the extracting solution of step in 2. is condensed into relative density.
3. the water of the lung-pulse ointment is obtained through refining Preparation Method according to claim 1, it is characterized in that: the 2. collected volatile oil of step joins and extracts in the concentrated solution.
4. the water of the lung-pulse ointment is obtained through refining Preparation Method according to claim 1, it is characterized in that: the 4. described emulsification condition of step is: in 20～90 ℃, normal pressure or vacuum pressure are to stir 1～40 minute under the condition of 0.01～0.09Mpa.
5. the water of the lung-pulse ointment is obtained through refining Preparation Method according to claim 1, it is characterized in that: the 3. described water of step is at least a in glycerol, propylene glycol, the water;
6. the water of the lung-pulse ointment is obtained through refining Preparation Method according to claim 1, it is characterized in that: the 4. described oil phase of step is at least a in liquid paraffin, Cera Flava, vaseline, the lanoline; Described emulsifying agent is that Tween-80, triethanolamine, hexadecanol, octadecanol, glyceryl stearate, fatty acid Pyrusussuriensis are smooth, at least a in the sodium lauryl sulfate, carbomer, polypropylene type.
7. the water of the lung-pulse ointment is obtained through refining Preparation Method according to claim 1, it is characterized in that: 5. step also adds the thickening agent of emulsifying ointment body weight 0.1%～10% or/and suspending agent.
8. obtain through refining Preparation Method as the water of the lung-pulse ointment as described in the claim 7, it is characterized in that: described thickening agent is at least a in methylcellulose, Sodium Tvlose, Polyethylene Glycol, sodium polyacrylate, hydroxypropyl emthylcellulose, hydroxyethyl-cellulose, glyceryl monostearate, the glycerin gelatine; Described suspending agent is at least a in gelatin, carbomer, vaseline, the hard paraffin.
9. the water of the lung-pulse ointment is obtained through refining Preparation Method according to claim 1, it is characterized in that: 5. step also adds the antiseptic of emulsifying ointment body weight 0.1%～10%.
10. obtain through refining Preparation Method as the water of the lung-pulse ointment as described in the claim 9, it is characterized in that: described antiseptic is benzoic acid, sodium benzoate, at least a in sodium nitrite, propanoic acid, sodium propionate, calcium propionate, nipalgin, glycerol, sorbic acid, the aromatic oil.
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| CN101181622B true CN101181622B (en) | 2010-09-15 |
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| CN101703751B (en) * | 2009-11-05 | 2012-01-25 | 甘肃奇正藏药有限公司 | Emplastrum for treating white-plus disease and preparation method thereof |
| CN108671208A (en) * | 2018-04-03 | 2018-10-19 | 奇正(北京)传统藏医药外治研究院有限公司 | The new application of white arteries and veins ointment |
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| CN1840154A (en) * | 2006-01-25 | 2006-10-04 | 甘肃奇正藏药有限公司 | Ointment for treating nervous damage and preparation method thereof |
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