CN101168503B - 从八角茴香中提取分离莽草酸的方法 - Google Patents
从八角茴香中提取分离莽草酸的方法 Download PDFInfo
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- CN101168503B CN101168503B CN2007100187732A CN200710018773A CN101168503B CN 101168503 B CN101168503 B CN 101168503B CN 2007100187732 A CN2007100187732 A CN 2007100187732A CN 200710018773 A CN200710018773 A CN 200710018773A CN 101168503 B CN101168503 B CN 101168503B
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- Prior art keywords
- shikimic acid
- organic solvent
- star anise
- concentrated
- iii
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- JXOHGGNKMLTUBP-HSUXUTPPSA-N shikimic acid Chemical compound O[C@@H]1CC(C(O)=O)=C[C@@H](O)[C@H]1O JXOHGGNKMLTUBP-HSUXUTPPSA-N 0.000 title claims abstract description 37
- JXOHGGNKMLTUBP-JKUQZMGJSA-N shikimic acid Natural products O[C@@H]1CC(C(O)=O)=C[C@H](O)[C@@H]1O JXOHGGNKMLTUBP-JKUQZMGJSA-N 0.000 title claims abstract description 37
- 238000000034 method Methods 0.000 title claims abstract description 20
- 240000007232 Illicium verum Species 0.000 title claims abstract description 16
- 235000008227 Illicium verum Nutrition 0.000 title claims abstract description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 37
- 239000003960 organic solvent Substances 0.000 claims abstract description 23
- 238000005238 degreasing Methods 0.000 claims abstract description 21
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 238000001914 filtration Methods 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 9
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 5
- 239000012141 concentrate Substances 0.000 claims abstract description 4
- 238000001035 drying Methods 0.000 claims abstract description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 21
- 238000000605 extraction Methods 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- 238000002425 crystallisation Methods 0.000 claims description 18
- 230000008025 crystallization Effects 0.000 claims description 18
- 239000000284 extract Substances 0.000 claims description 17
- 238000000926 separation method Methods 0.000 claims description 15
- 230000006837 decompression Effects 0.000 claims description 8
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 238000001953 recrystallisation Methods 0.000 claims description 5
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 16
- 235000012550 Pimpinella anisum Nutrition 0.000 abstract description 11
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract description 9
- 238000010992 reflux Methods 0.000 abstract description 3
- 240000009023 Myrrhis odorata Species 0.000 abstract 1
- 239000002778 food additive Substances 0.000 abstract 1
- 235000013373 food additive Nutrition 0.000 abstract 1
- 239000000047 product Substances 0.000 description 12
- 240000004760 Pimpinella anisum Species 0.000 description 10
- 238000005516 engineering process Methods 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 238000004042 decolorization Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000003208 petroleum Substances 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003810 ethyl acetate extraction Methods 0.000 description 1
- 238000010812 external standard method Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- JEHCHYAKAXDFKV-UHFFFAOYSA-J lead tetraacetate Chemical compound CC(=O)O[Pb](OC(C)=O)(OC(C)=O)OC(C)=O JEHCHYAKAXDFKV-UHFFFAOYSA-J 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 150000003364 shikimic acids Chemical class 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 238000003815 supercritical carbon dioxide extraction Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 230000003245 working effect Effects 0.000 description 1
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
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CN2007100187732A CN101168503B (zh) | 2007-09-29 | 2007-09-29 | 从八角茴香中提取分离莽草酸的方法 |
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CN2007100187732A CN101168503B (zh) | 2007-09-29 | 2007-09-29 | 从八角茴香中提取分离莽草酸的方法 |
Publications (2)
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CN101168503A CN101168503A (zh) | 2008-04-30 |
CN101168503B true CN101168503B (zh) | 2010-10-13 |
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Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102791671B (zh) * | 2010-03-12 | 2015-04-22 | 科学工业研究委员会 | 莽草酸的提取方法 |
CN103145550A (zh) * | 2013-03-27 | 2013-06-12 | 张达燕 | 从八角中提取莽草酸的方法 |
CN107652178B (zh) * | 2017-10-30 | 2021-07-27 | 广西玉蓝生物科技有限公司 | 从八角中提取莽草酸的方法 |
CN109134238A (zh) * | 2018-09-30 | 2019-01-04 | 那坡康正天然植物提取有限责任公司 | 一种从八角中提取莽草酸的生产工艺 |
CN111285761A (zh) * | 2020-03-25 | 2020-06-16 | 陕西嘉禾药业有限公司 | 八角中莽草酸的提纯方法 |
CN112876349A (zh) * | 2021-01-21 | 2021-06-01 | 梧州济众农林科技有限公司 | 一种从鲜八角果中提取莽草酸的方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1830939A (zh) * | 2006-04-12 | 2006-09-13 | 刘润民 | 一种便捷有效的莽草酸生产方法 |
CN1982279A (zh) * | 2005-11-14 | 2007-06-20 | 邓薏 | 一种制备莽草酸的新技术 |
-
2007
- 2007-09-29 CN CN2007100187732A patent/CN101168503B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1982279A (zh) * | 2005-11-14 | 2007-06-20 | 邓薏 | 一种制备莽草酸的新技术 |
CN1830939A (zh) * | 2006-04-12 | 2006-09-13 | 刘润民 | 一种便捷有效的莽草酸生产方法 |
Non-Patent Citations (2)
Title |
---|
Richard Payne.Isolation of Shikimic Acid from Star Aniseed.《Journal of Chemical Education》.2005,第82卷(第4期),599-600. * |
廖洪利等.八角茴香中莽草酸的提取.《成都医学院学报》.2006,第1卷(第2期),130-131. * |
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Denomination of invention: Method for extracting and separating shikimic acid from star anise Effective date of registration: 20140822 Granted publication date: 20101013 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: Shanxi Jiahe Plant Chemical Co., Ltd. Registration number: 2014610000018 |
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Inventor after: Yang Junren Inventor after: Xiao Hong Inventor after: Wang Xiaoying Inventor after: Wang Chunde Inventor after: Qi Chunlei Inventor after: Gao Juan Inventor after: Deng Shangyong Inventor before: Wang Chunde Inventor before: Qi Chunlei Inventor before: Gao Juan Inventor before: Wang Xiaoying Inventor before: Deng Shangyong Inventor before: Xiao Hong |
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Denomination of invention: Method for extracting and separating shikimic acid from star anise Effective date of registration: 20180206 Granted publication date: 20101013 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM CO., LTD. Registration number: 2018990000131 |
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Denomination of invention: Method for extracting and separating shikimic acid from star anise Effective date of registration: 20190411 Granted publication date: 20101013 Pledgee: Bank of Xi'an Limited by Share Ltd high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM CO., LTD. Registration number: 2019610000066 |
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Denomination of invention: Extraction and separation of shikimic acid from Illicium verum Effective date of registration: 20200910 Granted publication date: 20101013 Pledgee: Bank of Xi'an Limited by Share Ltd. high tech branch Pledgor: SHAANXI JIAHE PHYTOCHEM Co.,Ltd. Registration number: Y2020610000141 |
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Application publication date: 20080430 Assignee: SHAANXI JIAHE PHARMACEUTICAL CO.,LTD. Assignor: SHAANXI JIAHE PHYTOCHEM Co.,Ltd. Contract record no.: X2021980014566 Denomination of invention: Method for extracting and separating shikimic acid from star anise Granted publication date: 20101013 License type: Common License Record date: 20211209 Application publication date: 20080430 Assignee: Sanyuan Runhe Biological Technology Co.,Ltd. Assignor: SHAANXI JIAHE PHYTOCHEM Co.,Ltd. Contract record no.: X2021980014416 Denomination of invention: Method for extracting and separating shikimic acid from star anise Granted publication date: 20101013 License type: Common License Record date: 20211208 |