CN101167973B - Traditional Chinese medicine for treating hyperlipemia - Google Patents

Traditional Chinese medicine for treating hyperlipemia Download PDF

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CN101167973B
CN101167973B CN2007100190167A CN200710019016A CN101167973B CN 101167973 B CN101167973 B CN 101167973B CN 2007100190167 A CN2007100190167 A CN 2007100190167A CN 200710019016 A CN200710019016 A CN 200710019016A CN 101167973 B CN101167973 B CN 101167973B
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chinese medicine
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hyperlipidemia
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马万凯
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Abstract

The invention relates to a Chinese traditional medicament for curing hyperlipaemia, characterized in that the proportion by weight of the following materials is that astragalus 30.0-60.0, peach kernel 6.0-15.0, safflower 6.0-15.0, fleece-flower root 15.0-30.0, americanwater plantain 10.0-30.0, haw 10.0-30.0, pinellia tuber 6.0-15.0, tangerine peel 6.0-15.0, tuckahoe 10.0-30.0, liquorice 3.0-10.0,bamboo shavings 6.0-20.0, and immature bitter orange 6.0-20.0. Towards the combined hypertension, the medicament can be charged with gastrodia elata 10.0-15.0, uncaria 10.0-30.0, abalone shell 20.0-30.0, and achyranthes 10.0-20.0. Towards the combined blood hyperviscosity syndrome, the medicament can be charged with earthworm 10.0-20.0 and bloodsucker 3.0-9.0. Towards the combined fatty liver, the medicament can be charged with polygonum cuspistum 10.0-20.0 and cassia tora 10.0-20.0. The invention has good curative effect, short period of treatment, low charge and small side effect through the clinical application, applicable to various diseases induced by hyperlipaemia. The observed result of the clinical curative effect of the invention which is used in Chinese traditional medicament hospital in Chencang District, Baoji City, Shanxi Province shows that the cure rate is 70.5%, and the total effective rate is 98.4%.

Description

A kind of Chinese medicine for the treatment of hyperlipidemia
Technical field
The present invention relates to a kind of Chinese medicine for the treatment of hyperlipidemia.
Background technology
In recent years, raising along with people's living standard, Sheng is crossed in nutrition, hyperlipidemia, high sticky blood, hypercholesterolemiapatients patients increase year by year, patient more than 40 years old accounts for more than 50%. and along with the arrival of China's aged tendency of population trend, the cardiovascular and cerebrovascular disease sickness rate that hyperlipidemia, high sticky blood, hypercholesterolemia cause increases year by year, but the treatment cost height of cardiovascular and cerebrovascular disease, cure rate is low, sequela is many, therefore, blood fat reducing, the key that glutinous treatment is only the prevention cardiovascular and cerebrovascular disease is fallen.The most side effect of blood fat reducing Western medicine of clinical practice now is big, and what have all has infringement to Liver and kidney, as Xuezhikang, and fish oil fat reducing pill, gemfibrozil, simvastatin class.Chinese medicine lipid lowerers kind is few, as Herb Gynostemmae Pentaphylli, and Folium Ginkgo etc., and lipid-lowering effect is slow, can not adapt to clinical needs far away.
Summary of the invention
The technical problem that the present invention solves: a kind of Chinese medicine for the treatment of hyperlipidemia is provided, through the clinical practice good effect, short treating period, expense is low, side effect is little, be applicable to the various diseases that causes because of hyperlipemia, as coronary atherosclerosis, heart infarction, hypertensive cardiopathy, cardiomyopathy, cerebrovascular, cerebral arteriosclerosis, lacunar infarction, cerebral thrombosis, apoplexy sequela, liver cirrhosis, renal arteriosclerosis, diabetes etc., not only can in a short time blood fat be dropped to normal level, and above all diseases are all had the auxiliary treatment effect.
Treatment mechanism of the present invention: as far back as the argumentation of " interior warp " existing " obstruction of heart-QI person's arteries and veins is obstructed " relevant blood stasis such as " coagulation of blood in vessel giving rise to unsmooth pulse "." the Three Kingdoms " Huatuo say: " blood vessels circulation disease must not be given birth to "." this dirty piece of writing of Ling Shu Miraculous Pivot or Divine Axis " said: " blood and then passages through which vital energy circulates is popular ".So the reason of blood stasis is a lot, gas, cold, heat, emotion, life and diet etc. all can cause blood stasis and cause all kinds of diseases and ailments.Doctor trained in Western medicine is thought microcirculation disturbance, stagnates as the blood capillary slow blood flow and the stasis of blood, even intravascular coagulation, blood capillary distortion, oozing of blood and hemorrhage around the blood capillary; Reasons such as hemorheology is unusual all can cause thrombosis." dredge its QI and blood, make its accent reach " of " interior warp " record become the basis of blood circulation promoting and blood stasis dispelling rule of treatment later age.Its blood vessels of living of " invigorating blood circulation " promptly by adjusting various factorss such as cardiovascular function and hemorheology, promote the physiological function of blood circulation." blood stasis dispelling " its stasis of blood of promptly dispelling stagnates, and by regulating blood coagulable status, improves blood lipid metabolism, and prevention thrombosis is prevented and treated atherosclerosis and tissue abnormalities hypertrophy etc., thereby eliminates the pathological state that has existed.Not from phlegm retention " fertile people's excessive phlegm ", prompting " phlegm syndrome " is relevant unusually with lipid metabolism at Chinese medical discrimination for hyperlipidemia." phlegm-damp " refers to water liquid Metabolic disorder.Comprise the organ-tissue dysfunction that interstice's hydrops and cellular edema cause.Phlegm retention refers to the tract hydrops more.Expectorant is turbid, refers to that blood fat increases more, the interior fat deposition.Pathological product and metabolite are detained in vivo.So clinical hyperlipidemia patient, the inevitable expectorant of the traditional Chinese medical science.
The present invention is the principal agent of blood circulation promoting and blood stasis dispelling with Semen Persicae, Flos Carthami.Its effect one is to improve the blood capillary blood flow to make its blood acceleration slowly of flowing.The 2nd, improve the blood capillary state and remove the blood capillary spasm, alleviate in the microcirculation the erythrocytic stasis of blood and stagnate and compile, blood capillary button loop top blood stasis is reduced or disappear, the blood capillary clear-cut, the form trend is normal.The 3rd, reduce capillary permeability, blood capillary oozing of blood is on every side reduced or disappearance.The 4th, blood fat reducing.Semen Persicae, Flos Carthami can reduce serum total cholesterol, neutral fat and β---lipoprotein, and the T-CHOL and the TL of aorta wall also had the reduction effect, and the hemorheology of improvement and antithrombotic effect are arranged.Flos Carthami has the reduction surface activity of blood platelet, and anticoagulant improves the fibrinoclase activity, regulates hemorheological property, improves the effects such as tendency of " dense, glutinous, coagulate, gather " of blood, improves hemodynamics.Semen Persicae, Flos Carthami all have the expansion peripheral blood vessel and increase the effect of organic blood flow volume, and the effect of atherosclerosis and myocardial ischemia is arranged.Semen Persicae, Flos Carthami have the atheromatous plaque of disappearing effect, can obviously reduce foam cell, cellulose and slough in the sclerosis kitchen range, and can improve myocardial metabolism, strengthen anti-anoxia ability.The Radix Astragali can reduce the blood coagulation factor VIII procoagulant activity, so whole blood viscosity is reduced significantly effect.Fructus Crataegi can make lecithin ratio raising in the atherosclerosis, cholesterol reducing and the cholesterol ester deposition in arterial wall.Rhizoma Alismatis has anti-platelet aggregation and anti thrombotic action, and to reducing the blood coagulation degree, also there is remarkable efficacy the shortening fibrinolytic time; Simultaneously can also reduce amino acid content in the thrombosis, fibrin contribution in the hydrolysis thrombosis is arranged, can also make the thrombosis contraction in length, the thrombosis dry weight alleviates.Radix Polygoni Multiflori has significant blood fat reducing and study of anti-atherogenic effect, and obviously the high density lipoprotein increasing cholesterol levels alleviates atheromatous plaque and forms.The dry stomach humidifying of Rhizoma Pinelliae expectorant through pharmacological research, can obviously reduce TC and LDL-C, is the good medicine of treatment hyperlipemia.The Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm has blood fat reducing and control tremulous pulse medicated porridge induration, and the phosphinylidyne hesperidin has the effect of the serum cholesterol of reduction to experimental hyperlipidemia rabbit, and can alleviate and improve its aortosclerosis pathological changes significantly.Can prolong rats thrombosis or atherosclerosis time-to-live.The Poria invigorating spleen for diuresis is used for the treatment of fatty liver, hepatitis interstitialis chronica.Experimental results show that Poria can promote the degraded of hepatitis interstitialis chronica animal livers collagen protein, the interior fibrous tissue of liver is heavily absorbed.Glycyrrhizin in the Radix Glycyrrhizae has obvious effect for reducing fat to suffering from experimental hyperlipidemia rabbit, and plasma cholesterol and content of triglyceride are obviously reduced.Illustrate that glycyrrhizin can suppress the microsome cholesterol and form, the animal free fatty is mixed cholesterol is synthetic an inhibitory action.The Fructus Aurantii Immaturus pharmacological evaluation has the increase myocardial contraction, the effect of decreased heart rate and increase heart output.Caulis Bambusae In Taenia heat clearing away, relieving restlessness, sharp expectorant.But the shared QI invigorating in full side, invigorate blood circulation, expectorant.The clinical effect that reaches blood fat reducing, cholesterol and low-density lipoprotein cholesterol and blood viscosity keeps clear cardiovascular and cerebrovascular vessel for a long time, reduces atherosclerosis, prevention of cerebral hemorrhage, and cerebral thrombosis, myocardial infarction, and can reduce other medications of cardiovascular and cerebrovascular vessel.
The Pheretima collateral dredging has the function of anticoagulation, antithrombotic.TWO test Pheretima extracting solution has good anticoagulation, clotting time that can significant prolongation blood, and thrombin time, prothrombin time can reduce the viscosity of blood, suppresses thrombosis.Mechanism is the direct repression to thrombin-Fibrinogen reaction.Have fibrinolysis activity in addition,, suppress thrombosis by direct catalysis fibre Proteolytic enzyme.Hirudo has blood coagulation resisting function, and hirudin has affinity highly to thrombin, is the strongest thrombin special efficacy inhibitor of finding at present.The Hirudo decocting liquid has very strong anticoagulation, the fibrinogenic pool time of energy significant prolongation, and aorta and the interior speckle of coronary artery are disappeared significantly, the obvious hypertrophy of collagen fiber in the speckle, cholesterol crystal reduces, and can reduce whole blood viscosity, erythrocyte aggregation index, plasma viscosity, hematocrit.
The Rhizoma Gastrodiae suppressing the hyperactive liver and subsiding YANG has the function of blood pressure lowering, analgesia, microcirculation improvement.Gastrodine can make rabbits blood pressure descend, and total peripheral resistance is maximum to reduce by 41%, and blood vessel dilating, and the hypotensive effect of Rhizoma Gastrodiae is also relevant with blood vessel dilating.Rhizoma Gastrodiae liquid can react the vasoconstriction that antiadrenergic drug causes.Make blood pressure drops.Ramulus Uncariae Cum Uncis has hypotensive effect, is achieved by Rhomotoxine and the Ramulus Uncariae cum Uncis alkali regulating action to vasomotor center, peripheral nervous and neurotransmitter, heart and vascular function etc.The hypotensive effect of Ramulus Uncariae Cum Uncis and inhibition vasomotor center, the retardance sympathetic ganglion, the release that suppresses the teleneuron mediator is relevant, and the blood vessel dilating effect is arranged.It is unable that Radix Achyranthis Bidentatae cures mainly soreness of waist and knee joint muscles and bones, excessive rising of liver-YANG, and it is dizzy to have a headache.It is remarkable to share antihypertensive effect with Rhizoma Gastrodiae.Containing biological alkali diuresis by Radix Achyranthis Bidentatae brings high blood pressure down.The Concha Haliotidis suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving, pharmacological evaluation shows that the diuresis of Concha Haliotidis can make blood pressure drops.
The Rhizoma Polygoni Cuspidati master contains anthraquinone glycoside, emodin and polydatin, and multiple virus stain is had inhibitory action.The energy hepatic cholagogic obviously increases the liver and gall secretion, and lax bile duct expands about flesh, and polydatin has very strong inhibitory action to lipid peroxidation, can suppress the accumulation of lipid peroxidation at liver, thereby alleviate hepatic injury, plays liver-protective effect.Semen Cassiae contains obtusin, can obviously improve body inner cholesterol distribution situation, and it is atherosis to help prevention of arterial, and an anti-adenosine diphosphate (ADP) arachidonic acid is arranged, and collagen is embroidered the platelet aggregation effect of leading.The Semen Cassiae decoct can alleviate the infringement of harmful substances such as carbon tetrachloride to liver, and the Main Ingredients and Appearance that protects the liver is the Semen Cassiae glycosides.
The present invention is made by the following weight proportion raw material: Radix Astragali 30.0-60.0, Semen Persicae 6.0-20.0, Flos Carthami 6.0-15.0, Radix Polygoni Multiflori 15.0-30.0, Rhizoma Alismatis 10.0-30.0, Fructus Crataegi 10.0-30.0, Rhizoma Pinelliae 6.0-15.0, Pericarpium Citri Reticulatae 6.0-15.0, Poria 10.0-30.0, Radix Glycyrrhizae 3.0-10.0, Caulis Bambusae In Taenia 6.0-20.0, Fructus Aurantii Immaturus 6.0-20.0.
At complicated hypertension disease, also can add the following weight proportion raw material in the described Chinese medicine: Rhizoma Gastrodiae 10.0-15.0, Ramulus Uncariae Cum Uncis 10.0-30.0, Concha Haliotidis 20.0-30.0, cattle sunset 10.0-20.0.
At merging high sticky blood, also can add the following weight proportion raw material in the described Chinese medicine: Pheretima 10.0-20.0, Hirudo 3.0-9.0.
At merging fatty liver disease, also can add the following weight proportion raw material in the described Chinese medicine: Rhizoma Polygoni Cuspidati 10.0-20.0, Semen Cassiae 10.0-20.0.
Described Chinese medicine is said dosage form on any pharmaceutics.Described Chinese medicine is capsule, oral liquid, pill, powder.
Preparation method one: the present invention can be used as decoct, fries in shallow oil potion every day, adds water 500ml and fries in shallow oil secondary 300ml sub-service sooner or later altogether, and 10 days is a course of treatment, and get final product general 3 courses of treatment.
Preparation method two: said medicine is concocted by traditional handicraft, drying, pulverizing, effective component extracting and concentrated incapsulating form.Can continue repeatedly and take 1-3 month.
Preparation method three: the present invention also can be processed into oral liquid by existing pharmaceutical technology.Can continue repeatedly and take 1-3 month.
The present invention is through the clinical practice good effect, short treating period, expense is low, side effect is little, be applicable to the various diseases that causes because of hyperlipemia, as coronary atherosclerosis, heart infarction, hypertensive cardiopathy, cardiomyopathy, cerebrovascular, cerebral arteriosclerosis,, lacunar infarction, cerebral thrombosis, apoplexy sequela, liver cirrhosis, renal arteriosclerosis, diabetes etc., not only can in a short time blood fat be dropped to normal level, and above all diseases are all had the auxiliary treatment effect.The present invention is a cure rate 70.5% in the clinical observation on the therapeutic effect result of the Chencang District hospital of traditional Chinese hospital, Baoji, Shaanxi province city, total effective rate 98.4%.
The specific embodiment
Embodiment 1:
Proportioning raw materials (weight ratio): the Radix Astragali 30.0, Semen Persicae 10.0, Flos Carthami 10.0, the Radix Polygoni Multiflori 15.0, Rhizoma Alismatis 30.0, Fructus Crataegi 30.0, the Rhizoma Pinelliae 10.0, Pericarpium Citri Reticulatae 10.0, Poria 15.0, Radix Glycyrrhizae 3.0, Caulis Bambusae In Taenia 10.0, Fructus Aurantii Immaturus 10.0.
Preparation and instructions of taking: get above-mentioned Chinese medicine and fry in shallow oil secondary, add water 500ml at every turn, twice medicinal liquid merging obtained the 300ml medicinal liquid, fry in shallow oil potion every day, sub-service sooner or later, 10 days is a course of treatment, get final product general 3 courses of treatment.
Embodiment 2:
Proportioning raw materials (weight ratio): the Radix Astragali 60.0, Semen Persicae 20.0, Flos Carthami 15.0, the Radix Polygoni Multiflori 30.0, Rhizoma Alismatis 10.0, Fructus Crataegi 10.0, the Rhizoma Pinelliae 15.0, Pericarpium Citri Reticulatae 15.0, Poria 30.0, Radix Glycyrrhizae 10.0, Caulis Bambusae In Taenia 20.0, Fructus Aurantii Immaturus 20.0, Pheretima 15.0, Hirudo 6.0.
Preparation and instructions of taking are identical with embodiment 1.
Embodiment 3:
Proportioning raw materials (weight ratio): the Radix Astragali 50.0, Semen Persicae 15.0, Flos Carthami 8.0, the Radix Polygoni Multiflori 8.0, Rhizoma Alismatis 15.0, Fructus Crataegi 15.0, the Rhizoma Pinelliae 8.0, Pericarpium Citri Reticulatae 8.0, Poria 15.0, Radix Glycyrrhizae 5.0, Caulis Bambusae In Taenia 15.0, Fructus Aurantii Immaturus 15.0, Rhizoma Gastrodiae 10.0, Ramulus Uncariae Cum Uncis 15.0, Concha Haliotidis 30.0, cattle sunset 15.0.
Preparation method: said medicine is concocted by traditional handicraft, drying, pulverizing, effective component extracting and concentrate after incapsulate and form.
Embodiment 4:
Proportioning raw materials (weight ratio): the Radix Astragali 30.0, Semen Persicae 10.0, Flos Carthami 10.0, the Radix Polygoni Multiflori 15.0, Rhizoma Alismatis 30.0, Fructus Crataegi 30.0, the Rhizoma Pinelliae 10.0, Pericarpium Citri Reticulatae 10.0, Poria 15.0, Caulis Bambusae In Taenia 10.0, Fructus Aurantii Immaturus 10.0, Radix Glycyrrhizae 3.0, Rhizoma Polygoni Cuspidati 15.0, Semen Cassiae 15.0.
Preparation method: be processed into oral liquid by existing pharmaceutical technology and get final product.
The present invention is at the Chencang District hospital of traditional Chinese hospital, Baoji, Shaanxi province city clinical data.
Case: 61 routine patients all are clinic case, male 34 examples, women 27 examples, 30-79 year, 55 years old mean age.The course of disease is the shortest 1 year, the longest 36 years.Through integrative therapy 49 examples.Untreated 12 examples, accompanied with hypertension 46 examples, no hyperpietic's 15 examples.Hypercholesterolemia 48 examples, normal or on the low side 13 examples of cholesterol.61 examples all are that blood fat is higher, the minimum 1.70mmol/L of triglyceride, the highest 5.90mmol/L.II type 11 examples, III type 8 examples, IV type 36 examples, V-type 5 examples.
Treatment: differential diagnosis in tcm is an excessive rising of liver-YANG, qi depression to blood stasis, and the resistance of the phlegm-damp stasis of blood, the hepatic and renal YIN deficiency is seen more.Therapeutic Principle's blood circulation promoting and blood stasis dispelling, supplementing QI and nourishing YIN.
Medication: Radix Astragali 30.0-60.0, Semen Persicae 6.0-20.0, Flos Carthami 6.0-15.0, Radix Polygoni Multiflori 15.0-30.0, Rhizoma Alismatis 10.0-30.0, Fructus Crataegi 10.0-30.0, Rhizoma Pinelliae 6.0-15.0, Pericarpium Citri Reticulatae 6.0-15.0, Poria 10.0-30.0, Radix Glycyrrhizae 3.0-10.0, Caulis Bambusae In Taenia 6.0-20.0, Fructus Aurantii Immaturus 6.0-20.0.Add Rhizoma Gastrodiae 10.0-15.0 at complicated hypertension disease, Ramulus Uncariae Cum Uncis 10.0-30.0, Concha Haliotidis 20.0-30.0, cattle sunset 10.0-20.0.Add Pheretima 10.0-20.0, Hirudo 3.0-9.0 at merging high sticky blood.Add Rhizoma Polygoni Cuspidati 10.0-20.0, Semen Cassiae 10.0-20.0 at merging fatty liver disease.
Preparation and instructions of taking: get above-mentioned Chinese medicine and fry in shallow oil secondary, add water 500ml at every turn, twice medicinal liquid merging obtained the 300ml medicinal liquid, fry in shallow oil potion every day, sub-service sooner or later, 10 days is a course of treatment, get final product general 3 courses of treatment.
Criterion of therapeutical effect: (1) cures: chemical examination triglyceride 1.7mmol/L, and below the cholesterol 5.7mmol/L, HDL-C is more than 1.55mmol/L, and low-density lipoprotein cholesterol is below 3.10mmol/L.(2) produce effects: the chemical examination triglyceride is no more than 1.80mmol/L.Cholesterol is no more than 6mmol/L, and low-density lipoprotein cholesterol is below 3.30mmol/L.(3) effective: triglyceride, cholesterol descend in various degree, but are not less than produce effects.(4) invalid: with no change or increase relatively before the medication.
The result: 61 routine patients took 30 days, clinical cure 43 examples, produce effects 12 examples, effective 5 examples, invalid 1 example, total effective rate 98.4%.

Claims (6)

1. Chinese medicine for the treatment of hyperlipidemia is characterized in that it is made by the following weight proportion raw material: Radix Astragali 30.0-60.0, Semen Persicae 6.0-20.0, Flos Carthami 6.0-15.0, Radix Polygoni Multiflori 15.0-30.0, Rhizoma Alismatis 10.0-30.0, Fructus Crataegi 10.0-30.0, Rhizoma Pinelliae 6.0-15.0, Pericarpium Citri Reticulatae 6.0-15.0, Poria 10.0-30.0, Radix Glycyrrhizae 3.0-10.0, Caulis Bambusae In Taenia 6.0-20.0, Fructus Aurantii Immaturus 6.0-20.0.
2. a kind of Chinese medicine for the treatment of hyperlipidemia according to claim 1 is characterized in that also can adding the following weight proportion raw material in the described Chinese medicine: Rhizoma Gastrodiae 10.0-15.0, Ramulus Uncariae Cum Uncis 10.0-30.0, Concha Haliotidis 20.0-30.0, cattle sunset 10.0-20.0.
3. a kind of Chinese medicine for the treatment of hyperlipidemia according to claim 1 is characterized in that also can adding the following weight proportion raw material in the described Chinese medicine: Pheretima 10.0-20.0, Hirudo 3.0-9.0.
4. a kind of Chinese medicine for the treatment of hyperlipidemia according to claim 1 is characterized in that also can adding the following weight proportion raw material in the described Chinese medicine: Rhizoma Polygoni Cuspidati 10.0-20.0, Semen Cassiae 10.0-20.0.
5. according to claim 1 or 2 or 3 or 4 described a kind of Chinese medicines for the treatment of hyperlipidemia, it is characterized in that described Chinese medicine is said dosage form on any pharmaceutics.
6. a kind of Chinese medicine for the treatment of hyperlipidemia according to claim 5 is characterized in that described Chinese medicine is capsule, oral liquid, pill, powder.
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