CN102406743B - Traditional Chinese preparation for treating cerebral thrombosis - Google Patents
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Abstract
The invention relates to a traditional Chinese preparation for treating cerebral thrombosis. The traditional Chinese preparation is prepared from the following components: 9 g of cortex magnoliae officinalis, 12 g of citrus aurantium, 9 g of perilla seed, 9 g of spicebush root, 9 g of codonopsis, 9 g of astragalus mongholicus, 15 g of poria, 9 g of dried tangerine peel, 9 g of bighead atractylodes rhizome, 9 g of angelica, 3 g of pseudo-ginseng, 9 g of rhizoma ligustici wallichii, 9 g of red paeonia, 6 g of scorpion, 15 g of batryticated silkworm, 9 g of earthworm, 3 g of pangolin (vinegar baked), 9 g of salvia miltiorrhiza (wine stirred), 12 g of prepared rehmannia root, 15 g of spica prunella and 6 g of licorice (honey baked). The traditional Chinese preparation is prepared by adding two pieces of red jujube and two pieces of ginger which are used as medicinal guides to the above traditional Chinese medicines, adding 1000 mL of water, decocting at low fire for 45 minutes, fishing out residues, and filtering to obtain decoction. One dosage of the obtained decoction is administered in morning and evening of every day, and one course of treatment is 14 days. The above traditional Chinese medicines are reasonably matched, can treat both principal and secondary aspect of disease, are specific for pathogenesis, and have better treatment effect to cerebral thrombosis. The traditional Chinese preparation has rich medicine sources and low price, is convenient for administration and is easy to accept by patients.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically a kind of Chinese medicine preparation for the treatment of cerebral thrombosis.
Background technology
Cerebral thrombosis is a kind of cerebrovascular disease common at present, and cerebral thrombosis is on the basis of cerebral atherosclerosis, and under the condition that slow blood flow, blood pressure are on the low side, the inner membrance that blood formed element is attached to tremulous pulse forms thrombosis, is referred to as cerebral thrombosis.Main manifestations is hemiplegia, extremity moving obstacle, slurred speech etc. clinically.Old people falls ill more, and in patient, male is slightly more than women.Morbidity goes to toward some sign, such as, has limbs numb, the signs such as ineffective, the slurred speech of moving, dizzy, blurred vision.Most patient realizes elimination or slight obstacle.Nervus facialis and hypoglossal paralysis, nystagmus, muscular tension and abdomen hyporeflexia or enhancing, pathologic reflex is positive, stomach wall and cremasteric reflex weaken or disappear, simultaneously cerebral thrombosis also has that disability rate is high, relapse rate high, serious harm middle-aged and elderly people healthy, brings heavy burden to patient, family and society.Because the living standard of modern people improves day by day, the fat content absorbed in food increases greatly, and hyperlipidemia, high blood bran crowd increase, and the sickness rate of cerebral thrombosis is also raising gradually.
Clinically, western medical treatment mainly contains the medicines such as blood vessel dilating agent, depressor and anti-platelet aggregation agent, and these medicine side effect are comparatively large, and life-time service can bring injury in various degree to human organ.Chinese traditional treatment cerebral thrombosis achieves gratifying results in recent years, and traditional Chinese medical science thrombolytic therapy energy blood circulation promoting and blood stasis dispelling, dredging brain arteries and veins, fundamentally solve the problem of cerebral thrombosis, toxic and side effects is little, not easily recurs after controlling.
Summary of the invention
One is the object of the present invention is to provide to treat cerebral thrombosis effective, instant effect, the Chinese medicine that side effect is little.
A kind of Chinese medicine preparation for the treatment of cerebral thrombosis of the present invention, formulated by following ingredients: Cortex Magnoliae Officinalis 9g, Fructus Aurantii 12g, Fructus Perillae 9g, Radix Linderae 9g, Radix Codonopsis 9g, Radix Astragali 9g, Poria 15g, Pericarpium Citri Reticulatae 9g, Rhizoma Atractylodis Macrocephalae 9g, Radix Angelicae Sinensis 9g, Radix Notoginseng 3g, Rhizoma Chuanxiong 9g, Radix Paeoniae Rubra 9g, Scorpio 6g, Bombyx Batryticatus 15g, Pheretima 9g, Squama Manis (processed with vinegar) 3g, Radix Salviae Miltiorrhizae (wine stir-fry) 9g, Radix Rehmanniae Preparata 12g, Spica Prunellae 15g, Radix Glycyrrhizae (processed with honey) 6g.Get above-mentioned Chinese medicine, be priming with Fructus Jujubae two, two, Rhizoma Zingiberis Recens, add water 1000ml, slow fire boiling 45 minutes, drags for slag filtration and make decoction; Every day, potion, serviced once, 14 days courses for the treatment of sooner or later.
In formula of the present invention, each crude drug effect is as follows:
Cortex Magnoliae Officinalis: have another name called Cortex Magnoliae Officinalis, energy circulation of qi promoting removing food stagnancy; Dampness is except full; Lowering the adverse QI to relieve asthma.Experiment proves, Magnolol and Honokiol suppresses TXB2 to be formed in all cases, and in the cell caused by arachidonic acid or collagen, Ca raises and also suppressed by both.The antiplatelet effects of Magnolol and Honokiol is due to the suppression to Ca flowing in TXB2 and cell.
Fructus Aurantii: affect anesthetized dog intravenous injection Fructus Aurantii Immaturus injection 1ml/kg to blood flows such as the heart, brain, kidneys, has the significant effect increasing cerebral blood flow.Injection Cerebral Blood Flow Following on average increases by 82.6 ± 20.56ml/100g brain and weighs/minute (P < 0.01).Average increase number is equivalent to inject 86.4% of cerebral blood flow.Cerebral vascular resistance exponential average reduces by 0.428 ± 0.12 (P < 0.01), has the effect showing and reduce cerebral vascular resistance.
Fructus Perillae: sending down the abnormal ascending QI expectorant, relievings asthma, intestine moistening.QI rising in reverse order is stopped up, cough and asthma, dryness of the intestine constipation for expectorant.Fructus Perillae has expectorant sending down the abnormal ascending QI, relieving cough and relieving asthma, and profit cardiopulmonary, control QI rising in reverse order uncomfortable in chest, constipation function.
The Radix Linderae: promoting the circulation of QI to relieve pain, warming kidney for dispelling cold.The Radix Linderae has excitation to cardiac muscle, its volatile oil is for oral administration excited cardiac muscle, acceleration reflux cycle, boosting and perspiration, also have excited cerebral cortex, promote Repiration, local is coated with can distend the blood vessels, blood circulation is accelerated, the effect of alleviation composite muscle spasmic pain." explaining abstruseness of the canon of materia medica ": the pent-up of reason seven emotions, QI and blood is solidifying stops, and cholera is vomited and diarrhoea, and expectorant food is delaied." beautiful Chinese catalpa medicine solution ": removing blood stasis with potent drugs is let out full, pain relieving relieving distension.
Radix Codonopsis: Radix Codonopsis has invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed." Bencao Congxin " is recorded: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.Middle feeble QI is weak, mends in order to adjust, very smooth and proper." in sum, Radix Codonopsis enhancing human body immunity function, strengthen hemopoietic function, anti-stress, heart tonifying, shock, adjustment blood pressure, resist myocardial ischemia and the effect such as anticoagulant.
The Radix Astragali: " herbal classic " head speech carbuncle loses for a long time, evacuation of pus pain relieving, secondary speech strong wind leprosy disease, and five hemorrhoid scrofula, all use survivor, to dredge the heat defending gas.Though property temperature compensation, and blood circulation regulating can be led to, popular meridians, can not hinder in heap soil or fertilizer over and around the roots also stagnant.It controls deficiency of vital energy night sweat spontaneous perspiration, and dermatodynia, is the medicine of flesh table.Controlling the soft taste of spitting of blood, is the medicine in Central Region.The cold chi pulse that cures the wound is unlikely, the dirty insufficiency of primordial QI of the kidney invigorating, and baby's susceptible ailment said due to cold or exposure, all diseases of heating spontaneous perspiration, all with the person of processing, with the real void defending gas, is three burnt medicines inside and outside upper, middle and lower, the i.e. meaning of " herbal classic " tonify deficiency.
Poria: Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.
Pericarpium Citri Reticulatae: appetizing of regulating the flow of vital energy, drying dampness to eliminate phlegm, controls the spleen-stomach disease.For diseases such as distension and fullness of the chest and abdomen.The pungent loose logical temperature of Pericarpium Citri tangerinae, fragrant odour, is longer than and regulates the flow of vital energy, and can enter spleen lung, therefore can go loose sluggishness of lung-QI, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, gathers around stagnant, chest and diaphragm feeling of fullness and the disease such as stagnation of QI in spleen and stomach, distension and fullness in the abdomen for lung qi.
The Rhizoma Atractylodis Macrocephalae: invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.Its prothrombin time significant prolongation after rat oral gavage Rhizoma Atractylodis Macrocephalae decocting liquid.After Healthy People takes Rhizoma Atractylodis Macrocephalae decocting liquid or alcohol leaching liquid, its prothrombin time and the equal significant prolongation of clotting time.Clean ancient cloud: Rhizoma Atractylodis Macrocephalae dehumidifying benefit is dry, and middle QI invigorating, and blood between sharp waist umbilicus, except pathogenic heat in the stomach.
Radix Angelicae Sinensis: enrich blood; Invigorate blood circulation; Menstruction regulating and pain relieving; Moisturize laxation.The all cards of main blood deficiency; Menoxenia; Amenorrhea; Dysmenorrhea; Lump in the abdomen knot is poly-." book on Chinese herbal medicine just ": Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, and have benefit, the gas medicine in sincere blood in row, the panacea also in blood also.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.If stasis and be dysentery person, positive institute work as use, its will moving, cunning two words; If married woman's stasis in menstrual period, just before giving birth expedites the emergence of, and puerperal, youngster's pillow was had a pain, and tool is worked as monarch.
Radix Notoginseng: blood vessel dilating, to reduce blood pressure, improves microcirculation, increases blood flow, prevention and therapy heart and brain tissues ischemia, anoxia; Hemostasis, blood circulation promoting and blood stasis dispelling; Two-ways regulation blood glucose, reduction blood fat, cholesterol, suppression arteriosclerosis.
Rhizoma Chuanxiong: blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia.It is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving.
Radix Paeoniae Rubra: clearing away heat and cooling blood, eliminating stasis to stop pain.Anti-thrombosis function, Radix Paeoniae Rubra decoct 15-20g (crude drug)/kg, to rat oral gavage, makes thrombus formation time obviously extend, contraction in length, weight saving; Prothrombin time and KPTT extend, and euglobulin lysis time shortens, and shows there is remarkable inhibitory action to blood clotting.Antiplatelet aggregative activity, Radix Paeoniae Rubra extract all has remarkable inhibitory action to the platelet aggregation that epinephrine, adenosine diphosphate (ADP) (ADP), Trimeresurus (TMVA) and arachidonic acid (AA) are induced in vitro, and platelet adhesion and platelet factor III activity are reduced, platelet intensive amount raises.The mechanism of Radix Paeoniae Rubra arteriosclerosis may with improve lipoprotein component ratio, reduce plasma lipid peroxide, reduce doped calcium in arterial wall, anticoagulant, regulates TXA2/PGI2 balance and activated adenyl cyclase and to increase in arterial wall concentration etc. relevant.
Scorpio: endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.. " Shandong Chinese herbal medicine handbook ": endogenous wind stopping dredging collateral, spasmolytic.Control blood and fasten thromboangiitis obliterans, tuberculous lymphadenitis, tuberculosis of bone and joint, mumps.
Bombyx Batryticatus: relieving spasm by subduing liver-wind wind-expelling pain-stopping dissipating phlegm and resolving masses.Bombyx Batryticatus has anticoagulation, can suppress the formation of hematoblastic cohesion and thrombosis.
Pheretima: current meridians, available pyretic arthralgia of controlling saves swollen swelling pain; Suitable compatibility also can control arthralgia due to cold; Compatibility replenishing qi and promoting blood flow medicine is usually used in blood stasis due to qi deficiency, and meridians are unfavorable, aphasia hemiplegia person.Experiment proves: Pheretima has the effect of thrombolytic and anticoagulant, has and obviously can extend platelet thrombus and fibrinous thrombus formation time, thrombosis length and dry weight is reduced, and reduces blood viscosity.
Squama Manis: blood circulation promoting and dispersing pathogen accumulation; To stimulate the menstrual flow stimulating milk secretion; Eliminating carbuncle is burst hard.Main blood stasis amenorrhea; Lump in the abdomen; Rheumatic arthralgia; Agalactia; Carbuncle; The diseases such as scrofula.
Radix Salviae Miltiorrhizae: promoting blood flow to regulate menstruation, stasis-dispelling and pain-killing, removing heat from blood eliminating carbuncle, clear away heart-fire relieving restlessness, nourishing blood to tranquillize the mind.Antithrombus formation, improves plasmin activity; Extend bleeding and cotting time; Anticoagulant; Improve hemorheological properties (blood viscosity reduction, erythrocyte electrophoretic time are shortened).
Radix Rehmanniae Preparata: enrich blood moist; Benefit essence fills out marrow." pearl sac ": enrich blood greatly empty not enough, promoting blood circulation, physical strength profiting." Bencao Congxin ": kidney nourishing water, packing bone marrow, sharp blood vessels, tonification is Kidney-Yin hearing-improing and eyesight improving, hair color crow palpus.Again can tonifying the lung cloudy, upper chronic diarrhea, controls impairment caused by overstrain migratory arthralgia, cloudyly loses heating, and thousand expectorations are coughed, dyspnea with shortness of breath, emptiness of the stomach feels hungry, and pox demonstrate,proves no pus of having a guilty conscience, and shin stock is ached after being ill, the anxious pain of umbilicus abdomen in puerperal, and sense card the moon loses, lossless making is closed, all kinds of dynamic power, all hepatic and renal YIN deficiency, deficient all kinds of diseases and ailments, is strengthening renal yin to inhibit predominant yang medicine.
Spica Prunellae: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, and goiter, swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension, hyperglycemia, hyperlipidemia and high blood viscosity.。" explaining abstruseness of the canon of materia medica ": Spica Prunellae, takes a tonic or nourishing food to build up one's health cloudy blood vessels of fainting, can dredge stagnation of QI again.
Radix Glycyrrhizae: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
It is eliminating evil that formula of the present invention plays QI invigorating altogether, nourishing the liver and kidney, removing blood stasis, promoting blood circulation to remove obstruction in the collateral, and dredging brain arteries and veins, thrombolytic treats effect of paralysis.All medicine compatibilities are reasonable, and treating both the principal and secondary aspects of a disease, suits pathogenesis, and treatment cerebral thrombosis has good effect.
Formula of the present invention, medicine source is enriched, and cheap, taking convenience, patient takes like a shot.
Detailed description of the invention:
The invention will be further described in conjunction with the embodiments:
Embodiment: a kind of Chinese medicine preparation for the treatment of cerebral thrombosis, formulated by following ingredients: Cortex Magnoliae Officinalis 9g, Fructus Aurantii 12g, Fructus Perillae 9g, Radix Linderae 9g, Radix Codonopsis 9g, Radix Astragali 9g, Poria 15g, Pericarpium Citri Reticulatae 9g, Rhizoma Atractylodis Macrocephalae 9g, Radix Angelicae Sinensis 9g, Radix Notoginseng 3g, Rhizoma Chuanxiong 9g, Radix Paeoniae Rubra 9g, Scorpio 6g, Bombyx Batryticatus 15g, Pheretima 9g, Squama Manis (processed with vinegar) 3g, Radix Salviae Miltiorrhizae (wine stir-fry) 9g, Radix Rehmanniae Preparata 12g, Spica Prunellae 15g, Radix Glycyrrhizae (processed with honey) 6g.Get above-mentioned Chinese medicine, be priming with Fructus Jujubae two, two, Rhizoma Zingiberis Recens, add water 1000ml, slow fire boiling 45 minutes, drags for slag filtration and make decoction; Every day, potion, serviced once, 14 days courses for the treatment of sooner or later.
Model case:
1 Guo so-and-so, man, 57 years old, a day morning in February, 2010 got up and feels right hemianesthesia, and it is dilatory that lower limb are walked, and slurred speech, haves a medical check-up: BP150/105mmHg, sanity, and cardiopulmonary abdomen is without exception.CT looks into the blocking of head left frontal lobe thrombosis.Normal ECG.Take medicament of the present invention after being in hospital, every day, potion, sooner or later respectively once, treated after 14 days, lower limb walking is normal, and speaking, it is substantially clear to enunciate, two courses for the treatment of of continual cure, transference cure, check head CT cerebral thrombosis disappears, and electrocardiogram, routine blood test are normal, and healing is left hospital, so far without recurrence.
2. Jiao, man, 58 years old, feel when within 2009, November 26, rose in the morning that extremity activity is ineffective, companion's drinking-water was choked and is coughed.Come institute to check, have a medical check-up BP170/120mmHg, and cardiopulmonary abdomen is without exception, and head CT checks left cerebral infarction, electrocardio diagram chronic coronary.Take medicament of the present invention after being in hospital, every day, potion, point sooner or later took for twice, and it is movable normal treat extremity after 14 days, two courses for the treatment of of continual cure, and check head CT thrombosis disappears, and inspection electrocardiogram, routine blood test, hepatic and renal function, blood-fat and blood sugar all recover normal, leave hospital.Be in a course for the treatment of of after treatment, so far without recurrence.
3. Zhang, female, 65 years old, because prominent sense headache, dizzy, vomiting are admitted to hospital, had a medical check-up BP165/110mmHg, and cardiopulmonary abdomen is without exception, and head CT inspection shows that little cerebral thrombosis blocks, and other item inspection is normal.Give step after being admitted to hospital and step 250ml again, 20% mannitol 125ml, take medicament of the present invention, potion, divided and sooner or later took for twice every day simultaneously, totally 14 days, patient symptom is eliminated, and life sign recovers normal, the little brain shadow-free of check head CT, leave hospital and go home to continue to take a course for the treatment of of medicament after treatment of the present invention, without recurrence.
4. king so-and-so, man, 69 years old, upper left lower extremity paralysis, vertigo, vomiting, urinary incontinence three days.Have a medical check-up BP170/120mmHg in hospital, head CT checks, cerebrovascular blocks, the while of intravenous, take Chinese medicine preparation of the present invention, potion, divided and sooner or later took for twice, treat after 14 days every day, patient's headache, dizzy, symptoms of emesis disappearance, lower-limb muscular strength recovers, and after two courses for the treatment of of continual cure, patient's Myodynamia recovery is normal, check BP140/100mmHg, head CT, electrocardiogram, routine blood test, hepatic and renal function all recover normal, continue to take medicament after treatment of the present invention 30 days after leaving hospital, and pay a return visit without recurrence.
5. Zhang, female, 62 years old, prominent sense is dizzy, nauseating, blurred vision, comes institute and checks, have a medical check-up BP150/90mmHg, CT examination calvarium, occipitalia shade, and electrocardiogram, routine blood test, hepatic and renal function are normal, be diagnosed as cerebral thrombosis, be in hospital after give medicament of the present invention, every day potion, point sooner or later to take for twice, one the course for the treatment of transference cure, two courses for the treatment of of continual cure, check head CT, cranium portion shade disappears, and is discharged from hospitals upon recovery.
6. thank so-and-so, man, 63 years old, feel when morning rises that lower limb exercise is ineffective, walk dilatory, have a medical check-up when being admitted to hospital BP160/110mmHg, mind is clear, and cardiopulmonary abdomen is without exception, left lower extremity myasthenia, head CT shows that right substrate occurs that cerebral thrombosis blocks, and takes medicament of the present invention, every day potion, divide and sooner or later take for twice, treat two courses for the treatment of, check head CT, electrocardiogram, routine blood test, hepatic and renal function are all normal, left lower extremity Myodynamia recovery is normal, continues to strengthen the recovery from illness course for the treatment of and leaves hospital, without recurrence.
Claims (1)
1. treat a Chinese medicine preparation for cerebral thrombosis, it is characterized in that, formulated by following ingredients: Cortex Magnoliae Officinalis 9g, Fructus Aurantii 12g, Fructus Perillae 9g, Radix Linderae 9g, Radix Codonopsis 9g, Radix Astragali 9g, Poria 15g, Pericarpium Citri Reticulatae 9g, Rhizoma Atractylodis Macrocephalae 9g, Radix Angelicae Sinensis 9g, Radix Notoginseng 3g, Rhizoma Chuanxiong 9g, Radix Paeoniae Rubra 9g, Scorpio 6g, Bombyx Batryticatus 15g, Pheretima 9g, processed with vinegar Squama Manis 3g, Radix Salviae Miltiorrhizae 9g fried by wine, Radix Rehmanniae Preparata 12g, Spica Prunellae 15g, Radix Glycyrrhizae (processed with honey) 6g; Get above-mentioned Chinese medicine, be priming with Fructus Jujubae two, two, Rhizoma Zingiberis Recens, add water 1000ml, slow fire boiling 45 minutes, drags for slag filtration and make decoction.
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| CN102764326B (en) * | 2012-07-23 | 2014-07-09 | 高航 | Traditional Chinese medicine composition for treating coronary disease |
| CN102973794B (en) * | 2012-11-15 | 2015-09-09 | 龚允志 | A kind of Chinese medicine for the treatment of cerebral infarction, cerebral thrombosis |
| KR102216223B1 (en) * | 2019-07-16 | 2021-02-16 | 안동대학교 산학협력단 | Pharmaceutical composition comprising the mature fruit extract of magnolia denudata as an effective component for prevention or treatment of thrombosis and health functional food comprising the same |
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