CN101139280B - 无水醋酸钠的制备方法 - Google Patents
无水醋酸钠的制备方法 Download PDFInfo
- Publication number
- CN101139280B CN101139280B CN2007101574446A CN200710157444A CN101139280B CN 101139280 B CN101139280 B CN 101139280B CN 2007101574446 A CN2007101574446 A CN 2007101574446A CN 200710157444 A CN200710157444 A CN 200710157444A CN 101139280 B CN101139280 B CN 101139280B
- Authority
- CN
- China
- Prior art keywords
- sodium acetate
- anhydrous sodium
- preparation
- sub
- anhydrous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 229940040526 anhydrous sodium acetate Drugs 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 235000017281 sodium acetate Nutrition 0.000 claims abstract description 16
- BDKLKNJTMLIAFE-UHFFFAOYSA-N 2-(3-fluorophenyl)-1,3-oxazole-4-carbaldehyde Chemical compound FC1=CC=CC(C=2OC=C(C=O)N=2)=C1 BDKLKNJTMLIAFE-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229940087562 sodium acetate trihydrate Drugs 0.000 claims abstract description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 33
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 28
- 238000006243 chemical reaction Methods 0.000 claims description 20
- 238000001816 cooling Methods 0.000 claims description 8
- 238000002425 crystallisation Methods 0.000 claims description 8
- 230000008025 crystallization Effects 0.000 claims description 8
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 4
- 238000002347 injection Methods 0.000 abstract description 16
- 239000007924 injection Substances 0.000 abstract description 16
- 239000000126 substance Substances 0.000 abstract description 12
- 239000007788 liquid Substances 0.000 abstract description 11
- 208000010444 Acidosis Diseases 0.000 abstract description 10
- 206010027417 Metabolic acidosis Diseases 0.000 abstract description 10
- 239000000825 pharmaceutical preparation Substances 0.000 abstract description 4
- 239000000047 product Substances 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 239000013589 supplement Substances 0.000 abstract 2
- 238000003912 environmental pollution Methods 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 description 8
- 210000003722 extracellular fluid Anatomy 0.000 description 8
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 239000002775 capsule Substances 0.000 description 7
- 239000007935 oral tablet Substances 0.000 description 7
- 229940096978 oral tablet Drugs 0.000 description 7
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 4
- 235000011092 calcium acetate Nutrition 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- 239000001639 calcium acetate Substances 0.000 description 3
- 229960005147 calcium acetate Drugs 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 description 3
- 235000017550 sodium carbonate Nutrition 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical class CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000001632 sodium acetate Substances 0.000 description 2
- 229960004249 sodium acetate Drugs 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 1
- GWBWGPRZOYDADH-UHFFFAOYSA-N [C].[Na] Chemical compound [C].[Na] GWBWGPRZOYDADH-UHFFFAOYSA-N 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 238000005649 metathesis reaction Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007101574446A CN101139280B (zh) | 2007-10-11 | 2007-10-11 | 无水醋酸钠的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2007101574446A CN101139280B (zh) | 2007-10-11 | 2007-10-11 | 无水醋酸钠的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101139280A CN101139280A (zh) | 2008-03-12 |
CN101139280B true CN101139280B (zh) | 2011-02-16 |
Family
ID=39191411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2007101574446A Active CN101139280B (zh) | 2007-10-11 | 2007-10-11 | 无水醋酸钠的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101139280B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106349054A (zh) * | 2016-08-29 | 2017-01-25 | 南通奥凯生物技术开发有限公司 | 一种基于乙酸与纯碱生成无水乙酸钠的制备方法 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104788306B (zh) * | 2015-04-20 | 2016-07-06 | 江苏兄弟维生素有限公司 | 一种医药级无水醋酸钠的合成工艺 |
CN106349052B (zh) * | 2016-08-04 | 2018-11-09 | 南通奥凯生物技术开发有限公司 | 一种乙酸钠的制备方法 |
WO2019061213A1 (zh) * | 2017-09-29 | 2019-04-04 | 南通奥凯生物技术开发有限公司 | 一种乙酸钠的制备方法 |
CN111471177A (zh) * | 2020-05-11 | 2020-07-31 | 山东滨化滨阳燃化有限公司 | 一种纤维级聚苯硫醚树脂的工业化生产工艺及装置 |
CN111533910A (zh) * | 2020-05-11 | 2020-08-14 | 山东滨化滨阳燃化有限公司 | 一种注塑级聚苯硫醚树脂的工业化生产工艺及装置 |
-
2007
- 2007-10-11 CN CN2007101574446A patent/CN101139280B/zh active Active
Non-Patent Citations (2)
Title |
---|
杨章群等.复方醋酸钠注射液处方的改进及临床应用.中国药师 12.2006,(12),1166-1167. |
杨章群等.复方醋酸钠注射液处方的改进及临床应用.中国药师 12.2006,(12),1166-1167. * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106349054A (zh) * | 2016-08-29 | 2017-01-25 | 南通奥凯生物技术开发有限公司 | 一种基于乙酸与纯碱生成无水乙酸钠的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101139280A (zh) | 2008-03-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101139280B (zh) | 无水醋酸钠的制备方法 | |
CN102516130A (zh) | 一种盐酸二甲双胍的制备方法 | |
CN105801636A (zh) | 一种柚皮苷二氢查尔酮的合成方法 | |
CN104530087A (zh) | 一种头孢唑林钠新晶型及其制备方法 | |
CN101768168B (zh) | 头孢中间体的合成方法 | |
CN103113294B (zh) | 瑞巴派特的合成方法 | |
CN102964280B (zh) | 一种对甲苯磺酰脲的制备方法 | |
CN103265444A (zh) | 一种5-氨基乙酰丙酸磷酸盐的结晶方法 | |
CN104478972B (zh) | 一种采用自吸式搅拌高压釜制备曲克芦丁的方法 | |
CN102603901B (zh) | 利用晶种添加制备回生抗性淀粉的方法 | |
CN102146039A (zh) | 一种吉法酯化合物的合成工艺 | |
CN102432645B (zh) | 一种硫酸依替米星的纯化方法 | |
CN103012536A (zh) | 一种夫西地酸钠的结晶方法 | |
CN104031043A (zh) | 一种盐酸莫西沙星合成新方法 | |
CN102827044A (zh) | 一种半胱胺螯合锌的制备方法 | |
CN103130669B (zh) | 一种门冬氨酸钾的制备方法 | |
CN101781215A (zh) | 棓丙酯原料药化学半合成制备方法 | |
CN103483231B (zh) | 一种具有光学活性的蒜氨酸的合成方法及其反应装置 | |
CN102382072A (zh) | 一种d-环丝氨酸的精制方法 | |
CN103694280A (zh) | 从含有氨基葡萄糖盐酸盐母液中提取氨基葡萄糖盐酸盐的方法 | |
CN105061327B (zh) | 一种长效磺胺的合成方法 | |
CN103539733B (zh) | 一种对氨基水杨酸异烟肼的制备方法 | |
CN101817765A (zh) | 布洛芬精氨酸盐的制备方法 | |
CN101671334B (zh) | 一种帕马溴生产工艺 | |
CN113816916A (zh) | 一种磺胺异噁唑钠的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160922 Address after: Taian County in Liaoning province 121000 Anshan Zhenxing Road No. 85 Patentee after: Kangboshi Pharmaceutical Co., Ltd, Liaoning Address before: 121000 Jinzhou Tian Tian Pharmaceutical Co., Ltd., 36 Nanzhuang, Taihe District, Liaoning, Jinzhou Patentee before: Song Guilan Patentee before: Deng Yong |
|
TR01 | Transfer of patent right |
Effective date of registration: 20190529 Address after: 434300 No. 8 Langling Avenue, Gongan County, Jingzhou City, Hubei Province Patentee after: HUBEI DUORUI PHARMACEUTICAL CO., LTD. Address before: 121000 No. 85 Zhenxing Road, Taian County, Anshan City, Liaoning Province, 114100 Patentee before: Kangboshi Pharmaceutical Co., Ltd, Liaoning |
|
TR01 | Transfer of patent right |