CN101138648A - Method of preparing antimicrobial hemostasis Chinese medicine-containing biological dressings - Google Patents
Method of preparing antimicrobial hemostasis Chinese medicine-containing biological dressings Download PDFInfo
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- CN101138648A CN101138648A CNA2006101519938A CN200610151993A CN101138648A CN 101138648 A CN101138648 A CN 101138648A CN A2006101519938 A CNA2006101519938 A CN A2006101519938A CN 200610151993 A CN200610151993 A CN 200610151993A CN 101138648 A CN101138648 A CN 101138648A
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Abstract
The present invention is a biological dressing produced by the extraction liquid of the Chinese medicine with antibacterial and homeostasis properties comprising the soaking gall and the notoginseng, which takes the cotton, gauze or non-woven fabrics as the substrate and the chitosan as the membrane forming material. The present invention can be applied in the wound dressing for the burning wound and the injury. The present invention has characteristics of good biocompatibility, safety property, absorbing the wound exudates, antibacterial property, and homeostasis property and accelerating the healing in the wound. The main material of the present invention is the natural material.
Description
Affiliated technical field
The present invention relates to a kind of manufacture method that can be widely used in containing of wound surface of antibiotic, Hemostatic of traditional herb medicine pure-natural biological dressing.
Background technology
Wound dressing is divided into traditional dressing, biological dressing and synthetic dressing etc. according to its material composition.Wherein, biological dressing has characteristics such as excellent biological compatibility, safety, promotion wound healing be fast, therefore is subjected to people's favor.CN1275408 has reported from epithelium of animal and dermal tissue and to have extracted the technology that bioactive substance and collagen prepare biological dressing; CN1380109 has reported a kind of chitosan, collagen and calcium alginate compounded spongy biological dressing and processing technology thereof; " Chinese biological engineering in medicine journal " (1996,15 (2)) have reported that with chitosan, gelatin and glycerol be base stock, prepare wound dressing with glutaraldehyde as cross linker.Antibiotic, hemostatic function defect of insufficient that these biological dressings exist." institute of Military Medical Science Institute periodical " (1993,17 (1)) has reported the research of chitosan～norfloxacin burn dressing, the non-pure natural substance of this dressing, and synthetic drug wherein has certain toxic and side effects.And the chitosan that this series products is used makes the amino amount of product activity reduce owing to passed through the chemical modification processing of physics recrystallization or high substituted degree in the preparation process, and biocidal property reduces, and controls the traumatic infection ability and weakens.Therefore to have pure-natural biological dressing antibiotic, hemostatic function be significant and practical value in exploitation.
Summary of the invention
In order to overcome the deficiency of existing biological dressing, that the present invention is intended to realize to contain is antibiotic, the manufacturing of the pure-natural biological dressing of Hemostatic of traditional herb medicine, makes it possess excellent biological compatibility, safety, antibiotic, hemostasis simultaneously, promotes good characteristic such as wound healing.
The technical scheme that is adopted is: with Cotton Gossypii, gauze or non-woven fabrics is base material, dipping glycerol, chitosan solution, and antibiotic, Hemostatic of traditional herb medicine extracting solution such as Galla Chinensis, Radix Notoginseng are flooded in oven dry again, and drying promptly gets and contains antibiotic, Hemostatic of traditional herb medicine biological dressing.Cotton Gossypii, gauze or non-woven fabrics work wound exudate, the effect of protection wound surface of absorbing.Glycerol plays the plasticizer effect, can make the dressing softness.Gallic extracting solution has good inhibition effect to common infectious bacteria staphylococcus aureus of skin and bacillus pyocyaneus, mainly plays bacteriostasis.The Radix Notoginseng extracting solution plays the hemostasis effect.The chitosan biologically active can stop formation, the hypertrophy of connective tissue cell and the synthesizing of collagen protein of fibrin element, and have excellent biological compatibility, can absorb wound exudate, promotes characteristics such as wound healing and skin regeneration.In addition, chitosan has absorption, slow releasing function to medicine, makes the Chinese medicine effect more long-acting, avoids traumatic infection better, promotes wound healing.
The present invention has not only kept its excellent biological compatibility owing to used chitosan to be filmogen, and owing to used the natural Chinese medicine extracting solution as antibiotic, hemostatic material, its safety and antibiotic, haemostatic effect is more remarkable.
The specific embodiment
(1) extraction of pharmaceutically active ingredient in the antibacterial anti hemorrhagic
Take by weighing Chinese medicines such as an amount of Galla Chinensis, Radix Notoginseng, decoct respectively 2 times, add 8～20 times in water at every turn, decocted 2 hours.Filter merging filtrate.Decoction liquor is concentrated into 1/5 of original volume, gets concentrated solution.With complete to precipitation in 2 times of volume 95% ethanol adding concentrated solutions, sucking filtration gets filtrate.Filtrate is reclaimed ethanol through distillation, promptly gets the extracting solution that contains pharmaceutically active ingredient in the antibacterial anti hemorrhagic.
(2) contain the manufacturing of antibacterial anti hemorrhagic Chinese traditional medicine biology dressing
With Cotton Gossypii, gauze or non-woven fabrics is base material, with 0.5～5% glycerol, deacetylation is that 75～95% consumptions are 0.5～2.5% chitosan acetic acid (1%) solution impregnation base material, in 40～100 ℃ of oven dry down, the extracting solution of reuse Galla Chinensis, Radix Notoginseng floods, in 40～100 ℃ down dry, promptly get and contain pure-natural biological dressing antibiotic, Hemostatic of traditional herb medicine.
(3) biocidal property test
Slant culture one ring of depletion Staphylococcus aureus, escherichia coli, bacillus pyocyaneus is inoculated in the broth bouillon respectively, cultivate after 24 hours for 37 ℃, respectively get 0.2 milliliter and be inoculated in the plating medium, handle the dressing that makes with different Chinese medicine extraction liquid and carry out the biocidal property test, its result is as follows:
| Project | Staphylococcus aureus | Escherichia coli | Bacillus pyocyaneus | |||
| Dressing size (mm 2) | Inhibition zone size (mm 2) | Dressing size (mm 2) | Inhibition zone size (mm 2) | Dressing size (mm 2) | Inhibition zone size (mm 2) | |
| A B C D | 19×16 20×14 20×14 19×14 | 20×17 20×14 26×18 25×19 | 19×15 20×15 19×15 19×14 | 22×17 22×16 28×28 31×28 | 19×15 20×15 20×16 21×15 | 19×15 21×16 25×21 27×22 |
In the table, A: do not contain Chinese medicine extraction liquid B: Radix Notoginseng C: Galla Chinensis D: Radix Notoginseng+Galla Chinensis
The result shows, do not contain Chinese medicine or only handle the dressing fungistatic effect that makes relatively poor with the Radix Notoginseng extracting solution, and handle the dressing that makes staphylococcus aureus, escherichia coli, bacillus pyocyaneus are all had significant inhibitory effect, and the bacteriostasis of Galla Chinensis and Radix Notoginseng has cooperative effect with Galla Chinensis or Galla Chinensis+Radix Notoginseng extracting solution.
Claims (2)
1. one kind contains the dressing of antibacterial anti hemorrhagic Chinese traditional medicine biology.It is characterized in that with Cotton Gossypii, gauze or non-woven fabrics be base material, be added with glycerol, chitosan (deacetylation is 75～95%, consumption be 0.5～2.5%) and antibiotic, Hemostatic of traditional herb medicine extracting solution.
2. contain and be used as the Galla Chinensis of antibacterial anti hemorrhagic, the water extract-alcohol precipitation extracting solution of Radix Notoginseng Chinese medicine in the antibacterial anti hemorrhagic Chinese traditional medicine biology dressing manufacture method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101519938A CN101138648A (en) | 2006-09-07 | 2006-09-07 | Method of preparing antimicrobial hemostasis Chinese medicine-containing biological dressings |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101519938A CN101138648A (en) | 2006-09-07 | 2006-09-07 | Method of preparing antimicrobial hemostasis Chinese medicine-containing biological dressings |
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| CN101138648A true CN101138648A (en) | 2008-03-12 |
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| CNA2006101519938A Pending CN101138648A (en) | 2006-09-07 | 2006-09-07 | Method of preparing antimicrobial hemostasis Chinese medicine-containing biological dressings |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011523567A (en) * | 2008-05-02 | 2011-08-18 | プロビデンス ヘルス システム−オレゴン ディー／ビー／エー プロビデンス セント ビンセント メディカル センター | Wound dressing device and method |
| CN102995295A (en) * | 2012-12-17 | 2013-03-27 | 绍兴文理学院 | Panax pseudo-ginseng non-woven fabrics and method for preparing same |
| CN103230617A (en) * | 2013-04-24 | 2013-08-07 | 四川大学 | Collagen/chitosan micro-nano fiber composite hemostatic membrane material and preparation method thereof |
| US8668924B2 (en) | 2002-06-14 | 2014-03-11 | Providence Health System—Oregon | Wound dressing and method for controlling severe, life-threatening bleeding |
| CN103705972A (en) * | 2013-12-31 | 2014-04-09 | 程光起 | Antibacterial suture needle coating method |
| US8741335B2 (en) | 2002-06-14 | 2014-06-03 | Hemcon Medical Technologies, Inc. | Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as Chitosan |
| US8920514B2 (en) | 2006-05-23 | 2014-12-30 | Providence Health System—Oregon | Systems and methods for introducing and applying a bandage structure within a body lumen or hollow body organ |
| US9004918B2 (en) | 2001-06-14 | 2015-04-14 | Hemcon Medical Technologies, Inc. | Compositions, assemblies, and methods applied during or after a dental procedure to ameliorate fluid loss and/or promote healing, using a hydrophilic polymer sponge structure such as chitosan |
| CN104524624A (en) * | 2014-12-17 | 2015-04-22 | 安徽省健源医疗器械设备有限公司 | Chitosan hemostatic gauze and preparation method thereof |
| CN105012993A (en) * | 2015-08-25 | 2015-11-04 | 东莞市达庆医疗器械有限公司 | Medical and antibacterial cationic biogel dressing and preparation method thereof |
| US9204957B2 (en) | 2005-03-17 | 2015-12-08 | Hemcon Medical Technologies, Inc. | Systems and methods for hemorrhage control and or tissue repair |
| CN105288706A (en) * | 2015-10-22 | 2016-02-03 | 李星华 | Rapid bleeding-stopping dressing for department of gynaecology and obstetrics and preparation method of rapid bleeding-stopping dressing |
| CN107412520A (en) * | 2017-04-26 | 2017-12-01 | 苏州益可泰电子材料有限公司 | A kind of antibacterial anti hemorrhagic ointment, medicine and preparation method thereof |
| CN108560149A (en) * | 2018-03-27 | 2018-09-21 | 界首市圣通无纺布有限公司 | A kind of processing technology of high-performance antibiosis polypropylene spunbond non-woven fabrics |
| CN110201208A (en) * | 2019-06-18 | 2019-09-06 | 珠海稻田医疗科技有限公司 | A kind of hemostasis, sterilization dressing and preparation method thereof |
| CN111420113A (en) * | 2020-05-19 | 2020-07-17 | 山东大学 | Intelligent breathable dressing with antibacterial effect and preparation method thereof |
| CN113564920A (en) * | 2021-07-09 | 2021-10-29 | 青岛大学 | Medical care protective fabric for burns and preparation method thereof |
| CN115928416A (en) * | 2023-02-24 | 2023-04-07 | 潍坊医学院附属医院 | Hemostatic gauze and preparation method thereof |
-
2006
- 2006-09-07 CN CNA2006101519938A patent/CN101138648A/en active Pending
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9004918B2 (en) | 2001-06-14 | 2015-04-14 | Hemcon Medical Technologies, Inc. | Compositions, assemblies, and methods applied during or after a dental procedure to ameliorate fluid loss and/or promote healing, using a hydrophilic polymer sponge structure such as chitosan |
| US9132206B2 (en) | 2001-06-14 | 2015-09-15 | Hemcon Medical Technologies, Inc. | Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as chitosan |
| US8668924B2 (en) | 2002-06-14 | 2014-03-11 | Providence Health System—Oregon | Wound dressing and method for controlling severe, life-threatening bleeding |
| US8741335B2 (en) | 2002-06-14 | 2014-06-03 | Hemcon Medical Technologies, Inc. | Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as Chitosan |
| US8951565B2 (en) | 2003-12-23 | 2015-02-10 | Hemcon Medical Technologies, Inc. | Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as chitosan |
| US9204957B2 (en) | 2005-03-17 | 2015-12-08 | Hemcon Medical Technologies, Inc. | Systems and methods for hemorrhage control and or tissue repair |
| US8920514B2 (en) | 2006-05-23 | 2014-12-30 | Providence Health System—Oregon | Systems and methods for introducing and applying a bandage structure within a body lumen or hollow body organ |
| EP2279012A4 (en) * | 2008-05-02 | 2013-05-29 | Providence Health Sys Oregon | Wound dressing devices and methods |
| US9205170B2 (en) | 2008-05-02 | 2015-12-08 | Hemcon Medical Technologies, Inc. | Wound dressing devices and methods |
| JP2011523567A (en) * | 2008-05-02 | 2011-08-18 | プロビデンス ヘルス システム−オレゴン ディー／ビー／エー プロビデンス セント ビンセント メディカル センター | Wound dressing device and method |
| CN102995295B (en) * | 2012-12-17 | 2015-06-24 | 绍兴文理学院 | Panax pseudo-ginseng non-woven fabrics and method for preparing same |
| CN102995295A (en) * | 2012-12-17 | 2013-03-27 | 绍兴文理学院 | Panax pseudo-ginseng non-woven fabrics and method for preparing same |
| CN103230617B (en) * | 2013-04-24 | 2015-02-04 | 四川大学 | Collagen/chitosan micro-nano fiber composite hemostatic membrane material and preparation method thereof |
| CN103230617A (en) * | 2013-04-24 | 2013-08-07 | 四川大学 | Collagen/chitosan micro-nano fiber composite hemostatic membrane material and preparation method thereof |
| CN103705972A (en) * | 2013-12-31 | 2014-04-09 | 程光起 | Antibacterial suture needle coating method |
| CN104524624A (en) * | 2014-12-17 | 2015-04-22 | 安徽省健源医疗器械设备有限公司 | Chitosan hemostatic gauze and preparation method thereof |
| CN105012993B (en) * | 2015-08-25 | 2018-03-23 | 东莞市达庆医疗器械有限公司 | A kind of cation Medical Living Creature Gum antiseptic dressing and preparation method thereof |
| CN105012993A (en) * | 2015-08-25 | 2015-11-04 | 东莞市达庆医疗器械有限公司 | Medical and antibacterial cationic biogel dressing and preparation method thereof |
| CN105288706A (en) * | 2015-10-22 | 2016-02-03 | 李星华 | Rapid bleeding-stopping dressing for department of gynaecology and obstetrics and preparation method of rapid bleeding-stopping dressing |
| CN107412520A (en) * | 2017-04-26 | 2017-12-01 | 苏州益可泰电子材料有限公司 | A kind of antibacterial anti hemorrhagic ointment, medicine and preparation method thereof |
| CN108560149A (en) * | 2018-03-27 | 2018-09-21 | 界首市圣通无纺布有限公司 | A kind of processing technology of high-performance antibiosis polypropylene spunbond non-woven fabrics |
| CN110201208A (en) * | 2019-06-18 | 2019-09-06 | 珠海稻田医疗科技有限公司 | A kind of hemostasis, sterilization dressing and preparation method thereof |
| CN111420113A (en) * | 2020-05-19 | 2020-07-17 | 山东大学 | Intelligent breathable dressing with antibacterial effect and preparation method thereof |
| CN113564920A (en) * | 2021-07-09 | 2021-10-29 | 青岛大学 | Medical care protective fabric for burns and preparation method thereof |
| CN115928416A (en) * | 2023-02-24 | 2023-04-07 | 潍坊医学院附属医院 | Hemostatic gauze and preparation method thereof |
| CN115928416B (en) * | 2023-02-24 | 2023-04-28 | 潍坊医学院附属医院 | Hemostatic gauze and preparation method thereof |
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Application publication date: 20080312 |