CN101112429B - Medicine for treating hemorrhage and fin rot of aquatic animals - Google Patents
Medicine for treating hemorrhage and fin rot of aquatic animals Download PDFInfo
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- CN101112429B CN101112429B CN200710062521A CN200710062521A CN101112429B CN 101112429 B CN101112429 B CN 101112429B CN 200710062521 A CN200710062521 A CN 200710062521A CN 200710062521 A CN200710062521 A CN 200710062521A CN 101112429 B CN101112429 B CN 101112429B
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Abstract
The present invention relates to a drug to treat the diseases of aquatic animals, which is the drug to treat the bleeding and gill-rot diseases of the aquatic animals. The present invention solves the problem that the treatment effects of the traditional drugs in the prior art for the diseases of the aquatic animals are not obvious. The invention is composed of 400 to 1000 parts of jingganmycin and traditional Chinese pharmaceutical excipients, the traditional Chinese pharmaceutical excipients are composed of one or any two or all of 100 to 400 parts of lightyellow sophora root, 200 to 400 parts of rhubarb and 100 to 500 parts of hairyvein agrimonia herb and bud by weight ratio. The drug of the present invention has good treatment effects on bleeding disease, gill-rot and other diseases in the aquatic animals, which also has good prevention and treatment effects especially for the bleeding disease caused by vibrio spp in hot season, furthermore, the cured diseases are not liable to recurrence.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of aquatic animal, be specially and a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot.
Background technology
Along with the continuous development of aquaculture technology, cultivation density is also increasing, causes many infectious diseases to be difficult to effective control at last, thereby brings great economic loss for the Aquatic product aquaculture.Simultaneously, also make pathogen progressively produce drug resistance, traditional pharmaceutical efficacy is descended year by year even invalid owing to exist the phenomenon of antibiotic abuse in the treatment.And the drug residue of aquatic products limits and detection also is tending towards standard and strictness, can not adapt to by the way that strengthens the drug use amount.Therefore the drug use and the screening problem of disease control are current problem demanding prompt solutions in the aquaculture.
Hemorrhage, gill rot is the very big commonly encountered diseases of a kind of hazardness in the present aquaculture, is popular in annual May to October, spreads all over areas such as Guangdong, Fujian, Jiangsu, Jiangxi, Beijing-Tianjin Tang.It shows as, and mortality is big, dead longer duration, its dead total amount of severe patient surpasses cultures 20～30% of total amount, its anatomical features mainly contains: gill portion is seriously congested, and mucus is many and thick, the epidermis exudative hemorrhage, skin spreads all over red point or is erythema, a large amount of sticking phenomenons of taking off is arranged, and there are a large amount of ascites in the abdominal cavity, and it is yellow that liver is, the intestinal surface is congested, is phenomenon on an empty stomach.Determine mainly to cause through separating by pathogen such as vibrio parahaemolyticus.Ill Fish mainly contain Anguillar japonica, Ctenopharyngodon idellus, Carassius auratus, Hypophthalmichthys molitrix, Aristichthys nobilis, Cyprinus carpio etc.That traditional disinfectant and medicine mainly contain is chloride, bromine class disinfectant, quaternary ammonium salt, aldehyde disinfectant and part insecticide such as chrysanthemum esters etc., endo-medicine has norfloxacin, enrofloxacin, florfenicol etc., result of use is all not obvious, and recurrence easily, be difficult to control, especially past medical help substantially at high temperature season.The present invention provides a kind of and can effectively prevent and treat the medicine of diseases such as aquatic animal hemorrhagic disease in order to solve practical challenges in this production just.
Jingganmycin is the very strong agricultural antibiotic of interior absorption, and after plant absorbing, the contact thalline is absorbed by hyphal cell and conducts in mycelia very soon, disturbs and suppresses the normal growth reaction of somatic cells and play therapeutical effect.Be mainly used in and prevent and treat rice sheath blight disease, have protection and therapeutical effect concurrently, also can be used to prevent and treat wheat sharp eyespot, rice green smut, the leaf blight of corn, vegetable damping-off and root rot, Cotton Gossypii, beans, Radix Ginseng damping-off etc.Be mainly used in the control bacterial diseases of plants.
Summary of the invention
The present invention provides a kind of and has treated that aquatic animal is hemorrhage, the medicine of gill rot for the problem that solves the conventional medicament treatment aquatic animal disease DeGrain that exists in the prior art.
The present invention realizes by following technical scheme, a kind ofly treats that aquatic animal is hemorrhage, the medicine of gill rot, form by 400～1000 parts of jingganmycins and Chinese crude drug adjuvant,
The Chinese crude drug adjuvant is by any or wantonly two kinds or all form by weight proportion in 100～500 parts of 100～400 parts of the Radix Sophorae Flavescentiss, 200～400 parts of Radix Et Rhizoma Rhei, Herba Agrimoniae.
More than each component make finished product through traditional handicrafts such as screening, pulverizing, mixing, packing.Its use amount is that every kg feedstuff adds this medicine 0.5～1g, mixes concentration full pool spilling head or dipping bath that bait took or adopted 0.1～0.3ppm orally, effectively control over bleeding disease and gill rot.
Medicine of the present invention is based on jingganmycin, reach the purpose of killing pathogenic bacteria by pathogen cells normal developments such as interference and inhibition vibrio classes, can obviously improve combined therapy effect with removing heat from blood, hemostasis, antipyretic and antidotal type Chinese medicine after compound, reach treating both the principal and secondary aspects of a disease, consolidate the purpose of curative effect.The present invention is applied to jingganmycin in the treatment of the bacterial infective diseases for the treatment of aquatic animal first, and very obvious treatment effect is arranged.Find that through test medicine of the present invention has excellent curative to diseases such as aquatic animal hemorrhagic disease, gill rots, especially at high temperature season the hemorrhagic disease that is caused by vibrio is had good preventing, therapeutic efficiency, and use the back to be difficult for recurrence.
Actual effect of the present invention is detected according to the Ministry of Agriculture's new fishery Clinical Laboratory technical specification according to Zhejiang Institute of Fresh Water Aquatic Products: 1, the present invention to the aquatic animal The main pathogenic fungi to press down bactericidal action as follows, medicine of the present invention is 1.25mg/L to the MIC of freshwater fish bacterial septicemia pathogen BSK-10, tarda (ET), and MBC is 2.5mg/L; MIC, MBC to Trionyx sinensis (Wiegmann) beancurd sheet source of disease bacterium TL970528 are 0.625mg/L; MIC, MBC to Eriocheir sinensis pathogen CL99920 are 0.625mg/L, are 1.25mg/L to MIC, the MBC of Macrobrachium nipponensis(de Haan) pathogenic bacterium QXL-1; MIC to seawater fish morbid bacterium Vibro harveyi 1101-1 is 0.039mg/L, and MBC is 0.078mg/L, is 1.25mg/L to MIC, the MBC of vibrio alginolyticus NB.
2, the present invention is to the anxious toxicity test of Carassius auratus, Eriocheir sinensis, fresh water Macrobrachium nipponensis(de Haan), Macrobrachium rosenbergii and Trionyx sinensis (Wiegmann), and the present invention is to 96 hours LD of Carassius auratus
50Be 35.6mg/L, safe concentration is 3.56mg/L; 96 hours LD to the fresh water Macrobrachium nipponensis(de Haan)
50Be 26.3mg/L, safe concentration is 2.63mg/L; 96 hours LD to Macrobrachium rosenbergii
50Be 28.2mg/L, safe concentration is 2.82mg/L; 96 hours LD to Trionyx sinensis (Wiegmann)
50＞500mg/L, safe concentration＞50mg/L.The present invention is as the external water disinfectant, and the dosage that uses at aquaculture is 0.5mg/L, and more than experiment shows that it is safe that medicine of the present invention uses in aquaculture.
3, the present invention is to the prevention effect of freshwater fish bacteremic septicemia (disease outbreak); pathogen BSK-10 is after soaking mode of infection infection pond crucian carp; the medicament protection rate of using normal dose group of the present invention is 63.6%; the medicament protection rate of high dose group is 66.7%, and the medicament protection rate of low dose group is 33.3%.And with reference to " new fisheries drug clinical trial technical specification ", medicament protection rate＞60% is effectively, and therefore normal use amount 0.5mg/L is an effective and safe use amount of the present invention.
4, medicine of the present invention is to the influence of cultivating pool environment, and cultivating pool used behind the medicine of the present invention in 96 hours, and the rate of change of 06 year and 07 year test pond dissolved oxygen is respectively-6.48%～2.10% and-1.91%～3.82%; The rate of change of PH is respectively-0.75%～1.12% and-0.99%～2.10%; Nitrogen oxygen rate of change is respectively-2.58%～6.45% and-2.70%～2.70%, the reduction rate of nitrite nitrogen is respectively-5.93%～7.63% and-5.96%～6.50%, the rate of change of algae is respectively-3.25%～3.25% and-2.60%～1.30%, data show, behind the medicine of the present invention, the dissolved oxygen of cultivating pool, PH, nitrogen oxygen, nitrite and algae etc. do not have obviously influence.
Jingganmycin is main medicine in medicine of the present invention, Zhejiang Institute of Fresh Water Aquatic Products is detected the actual effect of jingganmycin according to the Ministry of Agriculture's new fishery Clinical Laboratory technical specification: 1, jingganmycin powder aquatic animal The main pathogenic fungi to press down bactericidal action as follows, MIC and MBC to freshwater fish bacterial septicemia pathogen BSK-10, Trionyx sinensis (Wiegmann) beancurd sheet pathogen TL970528 are 3.12mg/L, MBC is 6.24mg/L, MIC to Eriocheir sinensis pathogen CL99920 Macrobrachium nipponensis(de Haan) pathogenic bacterium QXL-1 is 1.56mg/L, and MBC is 3.12mg/L; MIC to tarda (ET), seawater fish morbid bacterium Vibro harveyi 1101-1 is 0.78mg/L, and MBC is 1.56mg/L; MIC to vibrio alginolyticus NB, Ctenopharyngodon idellus enteritis etiology bacterium 58-20-9 is that 0.39mg/L, MBC are 0.78mg/L.
2, the jingganmycin powder is to the anxious toxicity test of Carassius auratus, fresh water Macrobrachium nipponensis(de Haan), Macrobrachium rosenbergii and Trionyx sinensis (Wiegmann), and the jingganmycin powder is to 96 hours LD of Carassius auratus
50＞1000mg/L, safe concentration＞100.0mg/L; 96 hours LD to the fresh water Macrobrachium nipponensis(de Haan)
50Be 213.0mg/L, safe concentration is 21.30mg/L; 96 hours LD to Macrobrachium rosenbergii
50Be 330mg/L, safe concentration is 33.0mg/L; 96 hours LD to Trionyx sinensis (Wiegmann)
50＞1000mg/L, safe concentration＞100.0mg/L.The jingganmycin powder is as the external water disinfectant, and consumption is that 0.15mg/L (every mu every meter depth of water 100g) result shows that it is safe that this medicine uses in aquaculture.
3, the jingganmycin powder is irritated acute toxicity testing to the mouth of Carassius auratus, and the jingganmycin powder is irritated 96 hours LD to the Carassius auratus mouth
50＞2000mg/kg fish body weight, safe concentration LD
50＞200mg/kg fish body weight, in aquaculture, the daily ration, feeding quantity of aquatic animal is generally 3%～5% of fish body weight, therefore the using dosage of jingganmycin powder is 60～100mg/kg fish body weight (a 200g/100kg feedstuff), the result shows that as oral medicine, jingganmycin is safe to Fish.
4, the jingganmycin powder is to the prevention effect of freshwater fish bacteremic septicemia (outburst is sick); pathogen BSK-10 is after soaking mode of infection infection pond crucian carp; using the medicament protection rate of jingganmycin powder normal dose group is 60%; the medicament protection rate of high dose group is 65.7%, and the medicament protection rate of low dose group is 40%.And with reference to " new fisheries drug clinical trial technical specification ", medicament protection rate＞60% is effectively, and therefore normal use amount 0.15mg/L is an effective and safe use amount of the present invention.
Because in actual applications, only need water body or the intravital harmful pathogen of aquatic animal are controlled under the finite concentration, make it not reach diseases induced limit; And carry out pathogen to be killed fully and could measure in the evaluation of pesticide effectiveness process at laboratory, therefore actual working concentration will be lower than experimental data.
Typical treatment example 1
Freshwater aquiculture waters, coastal area, Tangshan City's in mid-July, 2005 is owing to the illumination deficiency, and air pressure is on the low side, and dissolved oxygen in water is lower than normal contents, and anaerobic bacteria breeds in a large number, dactylogyrider, and Trichodina, parasitic disease is comparatively general.By bacillary gill rot, it is too high that hemorrhagic disease etc. endanger serious fish diseases sickness rate, is multiple, recurrent cross occurrence.Ill Fish mainly are Fish such as crucian carp, silver carp, flathead, Cyprinus carpio, though through using traditional disinfectant such as strong chlorine oil, chlorine dioxide, containing the chrysanthemum esters and prevent and treat medicines such as gill rot and hemorrhagic disease certain curative effect is arranged, effect is all not obvious, and outbreak repeatedly occurs.There are Fish such as a main foster crucian carp in 400 mu of fishponds, silver carp, flathead, Cyprinus carpio in fishing ground, town, Fengnan District strand, mid-July occurs the phenomenon of Carassius auratus mortality.Use through its oneself to cure mainly the Carassius auratus mortality rate reduction of hemorrhagic disease fish medicine sterilization back with containing the chrysanthemum esters after killing the wheel animalcule medicine, Hypophthalmichthys molitrix but breaks out surplus in the of dead 4300, and mortality rate reaches more than 5%.Through Aquatic product technical advice station, Tangshan City check Hypophthalmichthys molitrix exophthalmos, the epidermis exudative hemorrhage, the oral cavity redness, intraperitoneal does not have food, has a large amount of yellow content logistics to go out, and it is yellow that the liver pancreas is, and looks sidelong at redness, with serious gill rot, meets the hemorrhagic disease feature fully.After using medicine of the present invention, recording the water quality pH value is 8.2, ammonia nitrogen 0.2mg/L, nitrite 0.01mg/L, dissolved oxygen 5mg/L, 400 mu of this pond waters surface, 1.8 meters of the depth of waters are used the full pond of 150 gram medicines of the present invention according to every mu of 1 meter depth of water, and administration time is 5: 20 afternoon.Mortality rate reduced significantly in second day, and only more than 30, the dead fish of accidental several tails after three days.Mu surplus this total cultured area 1700, also there is similar dead movement pattern of fish condition in other fish ponds, and symptom is a hemorrhagic disease, and gill rot has in time been used and has not all been caused a large amount of dead fish phenomenons behind the medicine of the present invention, and effect is very remarkable.Observing water quality after the medication does not have significant change, and water colour is normal, and not quantitative response does not appear in its sick fish, and the plankton breeding is normal in the water body.Calculate 1300 mu of waters surface of control 15 to 30 July according to two meters depth of waters and all obtain satisfied curative effect.
Typical treatment example 2, Anguillar japonica field, Guangdong, in early August, 06, Anguillar japonica appetite occurs and explodes (initial infection) after diagnosing for the hemorrhagic syndrome, every mu of depth of water uses medicine 250 grams of the present invention to carry out full pool spilling head for 1.5 meters, the bait food ration of Anguillar japonica is reduced to normal level in 2 days, and pathogen is controlled.
The specific embodiment
Embodiment 1: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 200～400 parts 400～1000 parts of jingganmycins and Radix Sophorae Flavescentis.
Embodiment 2: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 200 parts 1000 parts of jingganmycins and Radix Sophorae Flavescentis.
Embodiment 3: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 400 parts 400 parts of jingganmycins and Radix Sophorae Flavescentis.
Embodiment 4: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 100～400 parts 400～1000 parts of jingganmycins and Radix Et Rhizoma Rhei.
Embodiment 5: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 100 parts 400 parts of jingganmycins and Radix Et Rhizoma Rhei.
Embodiment 6: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 400 parts 1000 parts of jingganmycins and Radix Et Rhizoma Rhei.
Embodiment 7: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 100～500 parts 400～1000 parts of jingganmycins and Herba Agrimoniae.
Embodiment 8: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 500 parts 400 parts of jingganmycins and Herba Agrimoniae.
Embodiment 9: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 100 parts 1000 parts of jingganmycins and Herba Agrimoniae.
Embodiment 10: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 100～400 parts 400～1000 parts of jingganmycins and 200～400 parts of Radix Sophorae Flavescentiss, Radix Et Rhizoma Rhei.
Embodiment 11: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 100 parts 400 parts of jingganmycins and 200 parts of Radix Sophorae Flavescentiss, Radix Et Rhizoma Rhei.
Embodiment 12: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 400 parts 1000 parts of jingganmycins and 400 parts of Radix Sophorae Flavescentiss, Radix Et Rhizoma Rhei.
Embodiment 13: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 300 parts 400 parts of jingganmycins and 300 parts of Radix Sophorae Flavescentiss, Radix Et Rhizoma Rhei.
Embodiment 14: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 100～500 parts 400～1000 parts of jingganmycins and 100～400 parts of Radix Et Rhizoma Rhei, Herba Agrimoniae.
Embodiment 15: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 100 parts 400 parts of jingganmycins and 100 parts of Radix Et Rhizoma Rhei, Herba Agrimoniae.
Embodiment 16: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 500 parts 1000 parts of jingganmycins and 400 parts of Radix Et Rhizoma Rhei, Herba Agrimoniae.
Embodiment 17: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, by 200～400 parts of 400～1000 parts of jingganmycins and Radix Sophorae Flavescentiss, Herba Agrimoniae is formed for 100～500 parts by weight proportion.
Embodiment 18: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, by 200 parts of 400 parts of jingganmycins and Radix Sophorae Flavescentiss, Herba Agrimoniae is formed for 100 parts by weight proportion.
Embodiment 19: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, by 400 parts of 1000 parts of jingganmycins and Radix Sophorae Flavescentiss, Herba Agrimoniae is formed for 500 parts by weight proportion.
Embodiment 20: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, by 100 parts of 800 parts of jingganmycins and Radix Sophorae Flavescentiss, Herba Agrimoniae is formed for 100 parts by weight proportion.
Embodiment 21: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 100～500 parts 400～1000 parts of jingganmycins and 200～400 parts of Radix Sophorae Flavescentiss, 100～400 parts of Radix Et Rhizoma Rhei, Herba Agrimoniae.
Embodiment 22: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 200 parts 600 parts of jingganmycins and 200 parts of Radix Sophorae Flavescentiss, 200 parts of Radix Et Rhizoma Rhei, Herba Agrimoniae.
Embodiment 23: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 500 parts 1000 parts of jingganmycins and 200 parts of Radix Sophorae Flavescentiss, 100 parts of Radix Et Rhizoma Rhei, Herba Agrimoniae.
Embodiment 24: a kind ofly treat that aquatic animal is hemorrhage, the medicine of gill rot, be made up of by weight proportion for 100 parts 400 parts of jingganmycins and 400 parts of Radix Sophorae Flavescentiss, 400 parts of Radix Et Rhizoma Rhei, Herba Agrimoniae.
Claims (4)
1. treat that aquatic animal is hemorrhage, the medicine of gill rot for one kind, it is characterized in that: form by 400～1000 parts of jingganmycins and Chinese crude drug adjuvant,
The Chinese crude drug adjuvant is by any or wantonly two kinds or all form by weight proportion in 100～500 parts of 100～400 parts of the Radix Sophorae Flavescentiss, 200～400 parts of Radix Et Rhizoma Rhei, Herba Agrimoniae.
2. treatment aquatic animal according to claim 1 is hemorrhage, the medicine of gill rot, it is characterized in that: be made up of by weight proportion for 200 parts 600 parts of jingganmycins and 200 parts of Radix Sophorae Flavescentiss, 200 parts of Radix Et Rhizoma Rhei, Herba Agrimoniae.
3. treatment aquatic animal according to claim 1 is hemorrhage, the medicine of gill rot, it is characterized in that: be made up of by weight proportion for 300 parts 400 parts of jingganmycins and 300 parts of Radix Sophorae Flavescentiss, Radix Et Rhizoma Rhei.
4. treatment aquatic animal according to claim 1 is hemorrhage, the medicine of gill rot, it is characterized in that: by 100 parts of 800 parts of jingganmycins and Radix Sophorae Flavescentiss, Herba Agrimoniae is formed for 100 parts by weight proportion.
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| CN200710062521A CN101112429B (en) | 2007-08-02 | 2007-08-02 | Medicine for treating hemorrhage and fin rot of aquatic animals |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101721489B (en) * | 2009-12-24 | 2012-07-04 | 江南大学 | Plant extract formula for inhibiting aeromonas hydrophila |
| CN101961399A (en) * | 2010-06-23 | 2011-02-02 | 天津生机集团股份有限公司 | Preparation method of insecticide for aquatic animals |
| CN101961034B (en) * | 2010-09-21 | 2012-10-03 | 湖南康大生物药品有限责任公司 | Medicament for treating fish gill-rot diseases |
| CN102138994B (en) * | 2010-10-31 | 2014-12-10 | 仙桃市魏氏生物工程有限责任公司 | Pharmaceutical composition for preventing and treating black gill disease of aquatic animals |
| CN102048059B (en) * | 2010-12-27 | 2012-12-19 | 豆梅英 | Feed additive used for preventing and treating vibrio gill-rot disease of aquatic animals and preparation method thereof |
| CN104887843B (en) * | 2014-03-03 | 2020-12-22 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicine composition for preventing and treating fish gill rot disease and preparation method thereof |
| CN107373189A (en) * | 2017-07-20 | 2017-11-24 | 通化师范学院 | A kind of Chinese herbal feed additive for preventing and treating fresh water salmon fin rot and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1102333A (en) * | 1993-11-04 | 1995-05-10 | 张素芳 | Medicine for fish |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1102333A (en) * | 1993-11-04 | 1995-05-10 | 张素芳 | Medicine for fish |
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