CN101085211A - Traditional Chinese medicine preparation for treating lupoid nephritis - Google Patents
Traditional Chinese medicine preparation for treating lupoid nephritis Download PDFInfo
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- CN101085211A CN101085211A CN 200710117904 CN200710117904A CN101085211A CN 101085211 A CN101085211 A CN 101085211A CN 200710117904 CN200710117904 CN 200710117904 CN 200710117904 A CN200710117904 A CN 200710117904A CN 101085211 A CN101085211 A CN 101085211A
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Abstract
The invention relates to a Chinese medicinal preparation for treating lupus nephritis which is prepared from more than ten kinds of Chinese medicinal herbs including raw astragalus root, prepared rehmannia root, motherwort fruit and bark of peony root.
Description
Technical field
The present invention relates to treat the Chinese medicine preparation of lupus nephritis, is that a kind of lupus nephritis for the treatment of is the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.
Background technology
Systemic lupus erythematosus (sle) (SLE) is a kind of common connective tissue disease.Serve as main performance with heating, arthritis, erythra and kidney damage symptom clinically.Osler in 1904 and nineteen thirty-five Baehr point out that the lupus erythematosus patient has a series of internal organs phenomenon of getting involved, and comprising nephritis, claims lupus nephritis again.Generally acknowledge that at present primary disease is the immune complex disease that body is taken place endogenous (self) antigen, and with the disorder of T cell function.Being not only with skin plate-like erythema is the skin lesion of performance, a kind of especially autoimmune disease with multiple autoantibody that involves multisystem, many organs.Lupus nephritis (LN) is a topmost disease in the Secondary cases kidney disease.The number of the infected of systemic lupus erythematosus (sle) accounts for 50 examples/100,000 populations, and the sickness rate of China SLE is about 70,/10 ten thousand people, and according to the preliminary survey of Shanghai 30,000 textile female workers, prevalence is near 70.14/10 ten thousand people, and women's prevalence is 113.33/10 ten thousand people.The SLE kidney rate of getting involved is very high, if according to clinical manifestation, kidney is got involved and account for 1/4～2/3 in SLE.Kidney gets involved that performance gets involved with the outer organ of kidney can be not parallel, and the outer performance of some patient's kidney obviously and kidney is got involved gently; Some patient has tangible nephrotic syndrome or renal function injury but not to have tangible multisystem to get involved.According to general pathologic finding, the kidney affected individual accounts for 90%, adds ultramicroscope and the optical test of immunity battalion, and then nearly all systemic lupus erythematosus (sle) all has the nephropathy of varying degree.SLE is mainly in blue or green middle aged women, the woman: the ratio of male sickness rate is 9: 1.The nephropathy degree directly influences the prognosis of systemic lupus erythematosus (sle).Along with the application of glucocorticoid and cell toxicity medicament, the prognosis of primary disease has very big change.However, kidney is involved carrying out property renal function injury and is still one of primary disease major causes of death.Lupus nephritis belongs to the traditional Chinese medical science " YIN YANG toxin syndrome ", " maculae caused by violent heat pathogen ", " edema ", " lumbago " category more.
Chinese medicine is thought the formation of primary disease, and endogenous cause of ill belongs to innate deficiency more, plain body weakness, deficiency of both the liver and kidney, deficiency of both QI and YIN, the resistance of the channels stasis of blood.Exopathogenic factor is how relevant with the evil poison of impression, also may be relevant with factors such as overworked, internal injury caused by excess of seven emotions, chamber do not save.The clinical manifestation of primary disease is: light-duty, nephrotic syndrome type, nephritic syndrome type, acute renal failure type, tubular injury type, anti-phospholipid build, clinical " quietness " type.The traditional Chinese medical science is divided disease type Coryza Treated by Syndrome Differentiation such as excessive noxious heat, the hepatic and renal YIN deficiency, spleen kidney qi (sun) void, deficiency of both QI and YIN clinically, obtains very good effect.Invent a kind of not only safety but also effective Chinese medicine preparation, be significant.
Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide the Chinese medicine preparation for the treatment of lupus nephritis.Have determined curative effect, safe ready, have no side effect, cheap characteristics.
The present invention is made by the following weight proportion raw material:
1.0～4 parts of 1.0～4 parts of Rhizoma Anemarrhenaes of 1.5～6 parts of Radix Codonopsis of Radix Astragali
0.1～2 part of 1.0～4 parts of Radix Ophiopogonis of 1.5～6 parts of Poria of Radix Rehmanniae Preparata
0.1～2 part of 1.0～4 portions of Semen Plantaginis of 1.5～6 portions of Rhizoma Alismatis of Herba Leonuri
0.1～2 part of 1.0～4 portions of Radix Scrophulariae of 1.0～4 parts of Radix Salviae Miltiorrhizaes of Cortex Moutan.
The weight proportion of each raw material of optimization formula of the present invention is:
1.5～2.5 parts of 1.5～2.5 parts of Rhizoma Anemarrhenaes of 2.5～3.5 parts of Radix Codonopsis of Radix Astragali
0.5～1.5 part of 1.5～2.5 parts of Radix Ophiopogonis of 2.5～3.5 parts of Poria of Radix Rehmanniae Preparata
0.5～1.5 part of 1.5～2.5 portions of Semen Plantaginis of 2.5～3.5 portions of Rhizoma Alismatis of Herba Leonuri
0.5～1.5 part of 1.5～2.5 portions of Radix Scrophulariae of 1.5～2.5 parts of Radix Salviae Miltiorrhizaes of Cortex Moutan.
The weight proportion of each raw material of optimum formula of the present invention is:
2 parts of 2 parts of Rhizoma Anemarrhenaes of 3 parts of Radix Codonopsis of Radix Astragali
1 part of 2 parts of Radix Ophiopogonis of 3 parts of Poria of Radix Rehmanniae Preparata
1 part of 2 portions of Semen Plantaginis of 3 portions of Rhizoma Alismatis of Herba Leonuri
1 part of 2 portions of Radix Scrophulariae of 2 parts of Radix Salviae Miltiorrhizaes of Cortex Moutan.
Drug action mechanism among the present invention is as follows:
The Radix Astragali property of medicine is sweet, warm.Return lung, spleen channel.Has benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, the effect of promoting pus discharge and tissue regeneration strengthening.Can treat the card of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, the cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle is difficult bursts or bursts for a long time and do not hold back etc.(the 2813rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Radix Rehmanniae Preparata sweet in the mouth, slightly warm in nature.Have nourishing YIN and supplementing blood, beneficial essence is filled out the effect of marrow.Can treat soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair, anemia etc.(the 197th page of chief editor such as the firm Xiao Ying of party " Chinese medicine and health food development and exploitation " People's Health Publisher).
Herba Leonuri property of medicine suffering, hardship are slightly cold.Return liver, kidney, pericardium channel.Has promoting blood flow to regulate menstruation, inducing diuresis to remove edema, the effect of heat-clearing and toxic substances removing.Can treat menoxenia, amenorrhea, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, traumatic injury, dysuria, edema, carbuncle skin infection etc.(the 2697th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Cortex Moutan property of medicine hardship, suffering are slightly cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, the effect of promoting blood circulation to remove blood stasis.Can treat the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, the calentura later stage, hot Fu Yin divided heating, osteopyrexia and fever, and amenorrhea due to stagnation of blood, dysmenorrhea, mass in the abdomen, carbuncle sore tumefacting virus falls and pounces on the pain of injury, rheumatic arthralgia etc.(the 1578th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Radix Codonopsis property of medicine is sweet, and is flat.Return spleen, lung meridian.Has strengthening the spleen and tonifying the lung, the effect of supplementing QI for promoting the production of body fluid.Can treat weakness of the spleen and stomach, anorexia and loose stool, limbs fatigue, the deficiency of the lung is breathed with cough, the spontaneous perspiration of breathing hard, deficiency of both QI and blood etc.(the 2579th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Poria property of medicine is sweet, light, and is flat.GUIXIN, spleen, lung, kidney channel.Has promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can treat dysuria, the edema distension, is had loose bowels at phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, palpitation and restlessness, insomnia forgetfulness, seminal emission nebulousurine etc.(the 2154th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Rhizoma Alismatis property of medicine is sweet, light, and is cold.Return kidney, urinary bladder channel.Have promoting diuresis to eliminate damp pathogen, treating stranguria effect expels the heat-evil.Can treat dysuria, the puckery pain of pyretic stranguria, the edema distension is had loose bowels, dizziness due to fluid-retention, seminal emission etc.(the 2067th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Radix Salviae Miltiorrhizae property of medicine hardship is slightly cold.GUIXIN, pericardium, Liver Channel.Have blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, relieving restlessness is calmed the nerves, the effect of removing heat from blood eliminating carbuncle.Can treat menoxenia, dysmenorrhea, amenorrhea, the stasis of blood stagnated and suffered from abdominal pain puerperal, trusted subordinate's pain, lumps in the chest and abdomen, pyretic arthralgia swells and ache, traumatic injury, heat is gone into nutrient blood, dysphoria, vexed insomnia, carbuncle pyogenic infections from tumour or sore etc.(the 647th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Rhizoma Anemarrhenae property of medicine hardship, cold.Return lung, stomach, kidney channel.Has clearing away heat-fire, nourishing yin and moistening dryness.Can treat epidemic febrile disease hyperpyrexia excessive thirst, the cough due to lung-heat, osteopyrexia and fever, seminal emission, night sweat, restlessness of asrhenia type and insomnia is quenched one's thirst etc.(the 1924th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Sweet, the little hardship of the Radix Ophiopogonis property of medicine is slightly cold.Return lung, stomach, heart channel.Has nourishing YIN and moistening the lung, nourishing the stomach to promote the production of body fluid, the effect of the relieving restlessness that clears away heart-fire.Can treat dryness of the lung dry cough, lung abscess, deficiency of YIN chronic cough, Tianjin wound is thirsty, quenches one's thirst, and vexed insomnia is had sore throat, the dryness of the intestine constipation, heat in blood is told nosebleed etc.(the 1430th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Semen Plantaginis property of medicine is sweet, light, is slightly cold.Return lung, liver, kidney, urinary bladder channel.Have heat clearing away, diuresis makes eye bright, the expectorant effect.Can treat urinary obstruction, stranguria with turbid discharge, leukorrhagia, edema, the heat-damp in summer dysentery, conjunctival congestion is hidden from view, and the expectorant heat syndrome cough is breathed heavily etc.(the 539th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Radix Scrophulariae property of medicine is sweet, bitter, salty, is slightly cold.Return lung, stomach, kidney channel.Has removing heat from blood, nourishing YIN to lower pathogenic fire, antidotal effect.Can treat the warm febrile disease blood of joining the army, fever of the body, excessive thirst, crimson tongue is sent out speckle, the hectic fever due to YIN-deficiency chronic cough, fidgets due to deficiency is insomnia, and constipation is hindered in Tianjin, and order is puckery dim-sighted, laryngopharynx swelling and pain, tuberculous lymphadenitis, skin sore etc.(the 1062nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Radix Astragali, Radix Rehmanniae Preparata and Herba Leonuri; With Cortex Moutan, Radix Codonopsis, Poria, Rhizoma Alismatis, Radix Salviae Miltiorrhizae and the Rhizoma Anemarrhenae is ministerial drug; With Radix Ophiopogonis, Semen Plantaginis and Radix Scrophulariae is adjuvant.All medicines are harmonious, and are total to the tool supplementing QI and nourishing YIN, the effect of activating blood and promoting diuresis.The treatment lupus nephritis has determined curative effect, has no side effect taking convenience, cheap characteristics.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of Pharmacopoeia of People's Republic of China, utilizes the comprehensive function treatment lupus nephritis of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.
3, the present invention not only can effectively treat lupus nephritis, and the prevention of lupus nephritis is also had good effect, and the treatment lupus nephritis has determined curative effect, has no side effect taking convenience, cheap characteristics.
For showing the therapeutic effect of medicine of the present invention, as follows through clinical test results to the treatment lupus nephritis; Treatment lupus nephritis patient 12 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Three months is a course of treatment, take continuously three the course of treatment observe the curative effect.5 examples of fully recovering account for 41.67%, and 5 examples that take a turn for the better account for 41.67%, and more 2 examples do not account for 16.67%, and total effective rate reaches 83.33%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
The embodiment decoction takes by weighing raw material by following weight:
2 parts of 2 parts of Rhizoma Anemarrhenaes of 3 parts of Radix Codonopsis of Radix Astragali
1 part of 2 parts of Radix Ophiopogonis of 3 parts of Poria of Radix Rehmanniae Preparata
1 part of 2 portions of Semen Plantaginis of 3 portions of Rhizoma Alismatis of Herba Leonuri
1 part of 2 portions of Radix Scrophulariae of 2 parts of Radix Salviae Miltiorrhizaes of Cortex Moutan.
Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment lupus nephritis that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.Three months is a course of treatment.
Claims (3)
1, the Chinese medicine preparation of treatment lupus nephritis is characterized in that it is made by the following weight proportion raw material:
1.0～4 parts of 1.0～4 parts of Rhizoma Anemarrhenaes of 1.5～6 parts of Radix Codonopsis of Radix Astragali
0.1～2 part of 1.0～4 parts of Radix Ophiopogonis of 1.5～6 parts of Poria of Radix Rehmanniae Preparata
0.1～2 part of 1.0～4 portions of Semen Plantaginis of 1.5～6 portions of Rhizoma Alismatis of Herba Leonuri
0.1～2 part of 1.0～4 portions of Radix Scrophulariae of 1.0～4 parts of Radix Salviae Miltiorrhizaes of Cortex Moutan.
2, the Chinese medicine preparation of treatment lupus nephritis according to claim 1, wherein the weight proportion of each raw material is:
1.5～2.5 parts of 1.5～2.5 parts of Rhizoma Anemarrhenaes of 2.5～3.5 parts of Radix Codonopsis of Radix Astragali
0.5～1.5 part of 1.5～2.5 parts of Radix Ophiopogonis of 2.5～3.5 parts of Poria of Radix Rehmanniae Preparata
0.5～1.5 part of 1.5～2.5 portions of Semen Plantaginis of 2.5～3.5 portions of Rhizoma Alismatis of Herba Leonuri
0.5～1.5 part of 1.5～2.5 portions of Radix Scrophulariae of 1.5～2.5 parts of Radix Salviae Miltiorrhizaes of Cortex Moutan.
3, the Chinese medicine preparation of treatment lupus nephritis according to claim 1, wherein the weight proportion of each raw material is:
2 parts of 2 parts of Rhizoma Anemarrhenaes of 3 parts of Radix Codonopsis of Radix Astragali
1 part of 2 parts of Radix Ophiopogonis of 3 parts of Poria of Radix Rehmanniae Preparata
1 part of 2 portions of Semen Plantaginis of 3 portions of Rhizoma Alismatis of Herba Leonuri
1 part of 2 portions of Radix Scrophulariae of 2 parts of Radix Salviae Miltiorrhizaes of Cortex Moutan.
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| CN 200710117904 CN101085211A (en) | 2007-06-26 | 2007-06-26 | Traditional Chinese medicine preparation for treating lupoid nephritis |
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| CN 200710117904 CN101085211A (en) | 2007-06-26 | 2007-06-26 | Traditional Chinese medicine preparation for treating lupoid nephritis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666637A (en) * | 2015-03-18 | 2015-06-03 | 李�杰 | Traditional Chinese medicine composition for treating toxic heat flourishing lupus nephritis |
| CN105596750A (en) * | 2016-01-25 | 2016-05-25 | 何志彬 | Medicine for treating lupus nephritis |
-
2007
- 2007-06-26 CN CN 200710117904 patent/CN101085211A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104666637A (en) * | 2015-03-18 | 2015-06-03 | 李�杰 | Traditional Chinese medicine composition for treating toxic heat flourishing lupus nephritis |
| CN105596750A (en) * | 2016-01-25 | 2016-05-25 | 何志彬 | Medicine for treating lupus nephritis |
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Open date: 20071212 |