CN101081312A - Beta-titanium alloy material in biology medical application - Google Patents
Beta-titanium alloy material in biology medical application Download PDFInfo
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- CN101081312A CN101081312A CN 200710035286 CN200710035286A CN101081312A CN 101081312 A CN101081312 A CN 101081312A CN 200710035286 CN200710035286 CN 200710035286 CN 200710035286 A CN200710035286 A CN 200710035286A CN 101081312 A CN101081312 A CN 101081312A
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Abstract
The present invention discloses one kind of biomedicine beta-titanium alloy material comprising Ti-Nb 25-30 wt%, Zr 1-5 wt%, Fe 0.2-1 wt%, and Mo 10-15 wt%. The beta-titanium alloy material has non-toxic element and beta stabilizing element added into traditional biomedicine material, so that it has excellent comprehensive performances, including elastic modulus 45-66 GPa, breaking strength 650-960 MPa, yield strength 510-680 MPa, elongation 16-20 % and reduction of area 35-50 %. It has simple and reliable production process.
Description
Belong to technical field
The present invention relates to a kind of titanium alloy material, relate in particular to a kind of beta-titanium alloy material in biology medical application.
Background technology
Bio-medical material is an important branch of material science, being to be used to diagnose, treat or alternative tissue, organ or the novel carriers material promoting its function, have high technology content and high economic worth, is frontier that is developing in the material science and technology.Bio-medical material is made bigger contribution for exploration human life secret, guarantee human health longevity.Nearly 10 for many years, the growth rate of market of bio-medical material and goods remains on about 20%-25% always, estimate to comprise that the medical apparatus industry of bio-medical material will reach the pharmaceutical products market scale in following 10 years-15 years, become the pillar industry of 21 century World Economics.In the bio-medical metal material, titanium and alloy thereof rely on excellent comprehensive performances, become the preferred material of medical implants products such as artificial joint (hip, knee joint, shoulder, ankle, elbow, wrist, articulations digitorum manus etc.), bone wound product (intramedullary pin, steel plate, screw etc.), backbone correcting internal fixation system, tooth implant, dens supporter, tooth orthopedic wire, Cardiac valve prosthesis, intervention angiocarpy bracket.At present, also be not used for clinical than the better metal material of titanium alloy.But in the exploitation of medical titanium alloy, will research and develop low elastic modulus on the one hand, high-wear resistance, corrosion resistance and high-fracture toughness hang down crack growth rate, high damage tolerance, and have the biomedical beta-titanium alloy material of good biocompatibility; The component of alloy should be to pay attention to the prerequisite that is added to of nontoxic element on the other hand; In addition, should make great efforts to improve the quality level of China's biomedical titanium and alloy processing material thereof, walk investigation of materials institutes or institution of higher learning, manufacture of materials factory and medical research mechanism, the clinical medicine expert develops jointly road, the development of logging material, biocompatibility test, clinical medicine verify that in one accelerate development has the new bio medical titanium alloy material of broad prospect of application.
Summary of the invention
Technical scheme to be solved by this invention provides and a kind ofly can improve the strength of materials, wearability and corrosion stability, reduce elasticity modulus of materials, keep the beta-titanium alloy material in biology medical application of material well processed forming property, make titanium alloy material have good comprehensive serviceability.
The present invention proposes a kind of beta-titanium alloy material in biology medical application, its alloy component range is by percentage to the quality: Ti-Nb (25%～30%)-Zr (1%～5%)-Fe (0.2%～1%)-Mo (10%～15%).
Its preparation technology's flow process is: batching, fine vacuum electric arc melting add repeatedly and stir, cast, survey transformation temperature, vacuum and add argon shield homogenization, cold rolling, solid solution, shrend, artificial aging, water-cooled, performance test (stretching, microstructure observation, X ray phase structure are analyzed).Beta-titanium alloy have with the proximate elastic modelling quantity of people's bone, excellent biocompatibility and under biotic environment good corrosion resistance etc., obtained application more and more widely in recent years clinically, promoted the research and development of titanium alloy.When the element of alloying component is selected, consider that medical material must possess the biochemistry compatibility and biomechanical compatibility.The biochemistry compatibility is meant that material must not have cytotoxicity, tissue irritation, genetoxic, carcinogenecity, can not cause immunoreation, anaphylaxis etc.; Mechanical compatibility is meant the characteristic of the mechanical characteristic of material near reparation portion, even its function of life-time service does not change yet.In addition, when element is selected, should also be noted that and select beta stable element for use.Among the present invention, Ti, Nb, Zr, Fe are nontoxic element or low cytotoxicity element, good biocompatibility, can be β isomorphous element all in the mechanical property that changes alloy in varying degrees and anti-wear performance Nb, Mo, can be the slow eutectoid element of β with the β titanium Fe that infinitely dissolves each other, dissolubility in the β titanium can be saved in room temperature mutually with β, and alloy is produced the solution strengthening effect greater than the dissolubility in the α titanium under general rate of cooling.
The beta-titanium alloy material in biology medical application that the present invention proposes is on the basis of traditional bio-medical material, adds low toxicity or the avirulence element and the beta stable element of an amount of good biocompatibility, thereby improves the material combination property, satisfies the bio-medical instructions for use.
After beta-titanium alloy of the present invention adopts the fine vacuum electric arc melting to add repeatedly to stir, cast, survey transformation temperature, vacuum to add argon shield homogenization, cold rolling, solid solution, shrend, artificial aging, water-cooled; materials processing is become the thick sheet material of 2mm, prepare beta-titanium alloy bio-medical material with excellent comprehensive performance.
Material performance index is as follows respectively:
Elastic modelling quantity (GPa): 45-66; Fracture strength: 650-960; Yield strength (MPa): 510-680; Percentage elongation (%): 16-20; The contraction percentage of area (%): 35-50.
In sum, the present invention a kind ofly can improve the strength of materials, wearability and corrosion stability, reduces elasticity modulus of materials, keeps the beta-titanium alloy material in biology medical application of material well processed forming property, makes titanium alloy material have good comprehensive serviceability.Its production technology is simple and reliable.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1:
A) alloy preparation
Ti-25Nb-5 Zr-0.2Fe-15Mo alloy; Ti, Nb, Zr, Fe, Mo simple metal are by alloying component mass percent batching; melting in the fine vacuum arc heating furnace; fully stir; be cast into 100 * 60 * 20mm ingot blank, fully the sampling of cooling back is analyzed alloy solid-liquid phase temperature through DTA, carries out homogenizing annealing (adding the Ar gas shiled) in vacuum drying oven; homogenization temperature is 1000 ℃, and the time is 10h.
B) cold roll forming
Behind the ingot blank homogenizing annealing, the surface is the 19mm plate through being machined to thickness, and it is cold rolling to carry out multi-pass then, and being rolled to final thickness is 2mm, and total deformation is 89%.
C) heat treatment
Cold rolling back sample carries out solution treatment in chamber type electric resistance furnace, solid solubility temperature is 800 ℃, and solution time is 2 hours, carries out shrend after the solid solution, and the artificial aging temperature is 350 ℃, and aging time is 10 hours, uses water cooling after the timeliness.
D) material property
Elastic modelling quantity (GPa): 45; Fracture strength (MPa): 700; Yield strength (MPa): 550; Percentage elongation (%): 18; The contraction percentage of area (%): 36.
Embodiment 2:
A) alloy preparation
Ti-28Nb-3 Zr-0.6Fe-12Mo alloy; Ti, Nb, Zr, Fe, Mo simple metal are by alloying component mass percent batching; melting in the fine vacuum arc heating furnace; fully stir; be cast into 100 * 60 * 20mm ingot blank, fully the sampling of cooling back is analyzed alloy solid-liquid phase temperature through DTA, carries out homogenizing annealing (adding the Ar gas shiled) in vacuum drying oven; homogenization temperature is 1000 ℃, and the time is 10h.
B) cold roll forming
Behind the ingot blank homogenizing annealing, the surface is the 19mm plate through being machined to thickness, and it is cold rolling to carry out multi-pass then, and being rolled to final thickness is 2mm, and total deformation is 89%.
C) heat treatment
Cold rolling back sample carries out solution treatment in chamber type electric resistance furnace, solid solubility temperature is 800 ℃, and solution time is 2 hours, carries out shrend after the solid solution, and the artificial aging temperature is 350 ℃, and aging time is 10 hours, uses water cooling after the timeliness.
D) material property
Elastic modelling quantity (GPa): 55; Fracture strength (MPa): 800; Yield strength (MPa): 720; Percentage elongation (%): 19; The contraction percentage of area (%): 43.
Embodiment 3:
A) alloy preparation
The Ti-30Nb-1Zr-1Fe-10Mo alloy; Ti, Nb, Zr, Fe, Mo simple metal are by alloying component mass percent batching; melting in the fine vacuum arc heating furnace; fully stir; be cast into 100 * 60 * 2 0mm ingot blanks, fully the sampling of cooling back is analyzed alloy solid-liquid phase temperature through DTA, carries out homogenizing annealing (adding the Ar gas shiled) in vacuum drying oven; homogenization temperature is 1000 ℃, and the time is 10h.
B) cold roll forming
Behind the ingot blank homogenizing annealing, the surface is the 19mm plate through being machined to thickness, and it is cold rolling to carry out multi-pass then, and being rolled to final thickness is 2mm, and total deformation is 89%.
C) heat treatment
Cold rolling back sample carries out solution treatment in chamber type electric resistance furnace, solid solubility temperature is 800 ℃, and solution time is 2 hours, carries out shrend after the solid solution, and the artificial aging temperature is 350 ℃, and aging time is 10 hours, uses water cooling after the timeliness.
D) material property
Elastic modelling quantity (GPa): 60; Fracture strength (MPa): 910; Yield strength (MPa): 650; Percentage elongation (%): 17; The contraction percentage of area (%): 36.
Embodiment 4:
A) alloy preparation
The Ti-30Nb-5Zr-1Fe-15Mo alloy; Ti, Nb, Zr, Fe, Mo simple metal are by alloying component mass percent batching; melting in the fine vacuum arc heating furnace; fully stir; be cast into 100 * 60 * 20mm ingot blank, fully the sampling of cooling back is analyzed alloy solid-liquid phase temperature through DTA, carries out homogenizing annealing (adding the Ar gas shiled) in vacuum drying oven; homogenization temperature is 1000 ℃, and the time is 10h.
B) cold roll forming
Behind the ingot blank homogenizing annealing, the surface is the 19mm plate through being machined to thickness, and it is cold rolling to carry out multi-pass then, and being rolled to final thickness is 2mm, and total deformation is 89%.
C) heat treatment
Cold rolling back sample carries out solution treatment in chamber type electric resistance furnace, solid solubility temperature is 800 ℃, and solution time is 2 hours, carries out shrend after the solid solution, and the artificial aging temperature is 350 ℃, and aging time is 10 hours, uses water cooling after the timeliness.
D) material property
Elastic modelling quantity (GPa): 66; Fracture strength (MPa): 960; Yield strength (MPa): 680; Percentage elongation (%): 16; The contraction percentage of area (%): 35.
Embodiment 5:
A) alloy preparation
Ti-25Nb-1 Zr-0.2Fe-10Mo alloy; Ti, Nb, Zr, Fe, Mo simple metal are by alloying component mass percent batching; melting in the fine vacuum arc heating furnace; fully stir; be cast into 100 * 60 * 20mm ingot blank, fully the sampling of cooling back is analyzed alloy solid-liquid phase temperature through DTA, carries out homogenizing annealing (adding the Ar gas shiled) in vacuum drying oven; homogenization temperature is 1000 ℃, and the time is 10h.
B) cold roll forming
Behind the ingot blank homogenizing annealing, the surface is the 19mm plate through being machined to thickness, and it is cold rolling to carry out multi-pass then, and being rolled to final thickness is 2mm, and total deformation is 89%.
C) heat treatment
Cold rolling back sample carries out solution treatment in chamber type electric resistance furnace, solid solubility temperature is 800 ℃, and solution time is 2 hours, carries out shrend after the solid solution, and the artificial aging temperature is 350 ℃, and aging time is 10 hours, uses water cooling after the timeliness.
D) material property
Elastic modelling quantity (GPa): 45; Fracture strength (MPa): 650; Yield strength (MPa): 510; Percentage elongation (%): 20; The contraction percentage of area (%): 50.
Claims (1)
- A kind of beta-titanium alloy material in biology medical application is characterized in that: its alloy component range is by percentage to the quality: Ti-Nb (25%～30%)-Zr (1%～5%)-Fe (0.2%～1%)-Mo (10%～15%).
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101724764B (en) * | 2009-12-10 | 2011-07-20 | 中南大学 | Process for preparing biomedical beta-titanium alloy |
| CN108103354A (en) * | 2018-02-02 | 2018-06-01 | 贾红琴 | A kind of medical titanium alloy bone implant and preparation method thereof |
| CN112159913A (en) * | 2020-08-25 | 2021-01-01 | 中国石油天然气集团有限公司 | 135 ksi-grade titanium alloy, titanium alloy drill rod and preparation method thereof |
| CN115305385A (en) * | 2022-08-17 | 2022-11-08 | 暨南大学 | Low-cost, low-modulus, high-strength and high-wear-resistance biological titanium alloy and preparation method and application thereof |
| CN115652238A (en) * | 2022-10-26 | 2023-01-31 | 成都先进金属材料产业技术研究院股份有限公司 | Heat treatment method for improving cold heading performance of TB14 alloy wire for fastener |
-
2007
- 2007-07-05 CN CN 200710035286 patent/CN101081312A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101724764B (en) * | 2009-12-10 | 2011-07-20 | 中南大学 | Process for preparing biomedical beta-titanium alloy |
| CN108103354A (en) * | 2018-02-02 | 2018-06-01 | 贾红琴 | A kind of medical titanium alloy bone implant and preparation method thereof |
| CN112159913A (en) * | 2020-08-25 | 2021-01-01 | 中国石油天然气集团有限公司 | 135 ksi-grade titanium alloy, titanium alloy drill rod and preparation method thereof |
| CN112159913B (en) * | 2020-08-25 | 2022-03-01 | 中国石油天然气集团有限公司 | 135 ksi-grade titanium alloy, titanium alloy drill rod and preparation method thereof |
| CN115305385A (en) * | 2022-08-17 | 2022-11-08 | 暨南大学 | Low-cost, low-modulus, high-strength and high-wear-resistance biological titanium alloy and preparation method and application thereof |
| CN115652238A (en) * | 2022-10-26 | 2023-01-31 | 成都先进金属材料产业技术研究院股份有限公司 | Heat treatment method for improving cold heading performance of TB14 alloy wire for fastener |
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