CN101062085B - Condyloma acuminata treating medicine - Google Patents
Condyloma acuminata treating medicine Download PDFInfo
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- CN101062085B CN101062085B CN2006100761046A CN200610076104A CN101062085B CN 101062085 B CN101062085 B CN 101062085B CN 2006100761046 A CN2006100761046 A CN 2006100761046A CN 200610076104 A CN200610076104 A CN 200610076104A CN 101062085 B CN101062085 B CN 101062085B
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Abstract
The invention relates to a medicament for treating verruca acuminate which is prepared from raw material herbs of globe thistle 15-38, borneol 1-5, brucea fruit 5-25 and licorice root 5-25. The medicament can be prepared into externally used liniment.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of condyloma acuminatum, this medicine is pure Chinese medicine externally applied liniment, is used for the treatment of condyloma acuminatum.
Background technology
Condyloma acuminatum is one of current common sexually transmitted disease (STD).Condyloma acuminatum one speech means " point-like " or " point " from Greek, and synonym has genital wart, genital wart, anogenital wart.The pathogen of condyloma acuminatum is human papillomavirus (HPV), and this virus has many types, and the virus that causes people's condyloma acuminatum is types such as 6,11,16,18,31,33 wherein.The human papillomavirus is present on people's the skin or mucosa (does not have this virus) in the blood, damage proliferative pathological changes.The most normal men and women's external genitalia and the crissum of betiding of condyloma acuminatum, comparatively common with male's coronary sulcus, frenulum of prepuce and the large and small labia of women's perineum inboard, also be found in vagina and cervix uteri, the position beyond the genitals can take place by chance.If patient's primary disease after long-run development can not get effective treatment canceration can take place, cancer in situ and Invasive carcinoma pathological changes can take place.It is reported that a considerable amount of carcinomas of penis, the carcinoma of vulva, anus cancer are secondary to the condyloma acuminatum with the position.At present, condyloma acuminatum accounts for second and the trend of the first place of occupying is arranged in China's Dermatology.
The treatment of condyloma acuminatum is divided into Drug therapy and naturopathy (laser, freezing, microwave) at present substantially.What naturopathy was with the most use clinically is laser therapy, will inject anaesthetic before the laser therapy, burns the wart body with high energy laser beam during treatment, makes its carbonization, and coking wart body comes off after a couple of days.Enrich because of external genital is neural, the patient will stand more intensive pain usually, though clinical drug therapy is smaller than naturopathy to the misery that the patient brings, but some corrosive medicine, making the patient feel pain and itch when medicine-feeding, is that naturopathy or Drug therapy all will be through recovering this process normally from treatment beginning---wound surface heals fully---wound surface skin.These methods miseries are big and can only remove visible focus, can not eliminate sub-clinical state, the relapse rate height.
Utilize this disease of traditional Chinese medical herbal treatment that report was also once arranged, for example Chinese patent CN02153422.5 discloses a kind of Chinese medicine preparation for the treatment of condyloma acuminatum, it is a raw material with Chinese medicine Realgar, Fructus Bruceae, rawhide nitre, Borneolum Syntheticum, be configured to unguentum or water liniment in proportion, though certain effect is arranged, curative effect still can not be satisfactory.Therefore,, play original therapeutic effect, a kind of medicine unique, more scientific and reasonable, that curative effect is higher that has need be provided in order more reasonably to use Chinese medicine.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of condyloma acuminatum, this medicine is processed into externally applied liniment by selected kinds of traditional Chinese medicines raw material, the all medicines of the present invention share, performance group medicine is made a concerted effort, play heat-clearing and toxic substances removing altogether, the effect of wart of dispelling of drawing out pus by applying a plaster to the affected part, focus on and eradicate the wart body and eliminate wart and inferior clinical symptom incubation period, thereby reach the radical cure condyloma acuminatum.
The object of the present invention is achieved like this: a kind of medicine for the treatment of condyloma acuminatum, and it is the medicament of being made by following raw materials by weight proportions:
Radix Rhapontici 15～38
Borneolum Syntheticum 1～5
Fructus Bruceae 5～25
Radix Glycyrrhizae 5～25.
A kind of medicine for the treatment of condyloma acuminatum, it can also be the medicament of being made by following raw materials by weight proportions:
Radix Rhapontici 15～38
Borneolum Syntheticum 1～5
Fructus Bruceae 5～25
Radix Glycyrrhizae 5～25
Spina Gleditsiae 25～38.
A kind of medicine for the treatment of condyloma acuminatum, it can also be the medicament of being made by following raw materials by weight proportions:
Radix Rhapontici 15～38
Borneolum Syntheticum 1～5
Fructus Bruceae 5～25
Radix Glycyrrhizae 5～25
Spina Gleditsiae 25～38
Squama Manis 10～25.
A kind of medicine for the treatment of condyloma acuminatum, it can also be the medicament of being made by following raw materials by weight proportions:
Radix Rhapontici 15～38
Borneolum Syntheticum 1～5
Fructus Bruceae 5～25
Radix Glycyrrhizae 5～25
Spina Gleditsiae 25～38
Squama Manis 10～25
Herba Portulacae 10～25
Semen Coicis 10～25.
Medicament of the present invention is an externally applied liniment.
Medicine of the present invention is on the basis of the research condyloma acuminatum cause of disease, pathogenesis, and utilization motherland Chinese medical theory develops.The traditional Chinese medical science is referred to as condyloma acuminatum " condyloma acuminatum ", " urine wart ", thinks that this disease is because deficiency of both the liver and kidney, unclean, the damp and hot excessive poison of diseases caused by exogenous pathogenic factor of joining, the noxious dampness stagnation of blood stasis of making a bet, and the cohesion skin forms.Ancients' " Xue's medical records " (bright. Xue oneself, 1528) in " wart belongs to the liver and gall shaoyang channel, and wind heat blood is dry, or the liver-fire of flaring up, liver visitor excess of QI due to " early on the books.The present invention selects antiinflammatory sterilization for use, sterilizing and itch-relieving, the Chinese medicine of dampness pain relieving, dehumidifying removing heat from blood, clearing away heat to stop bleeding, eliminating fire and detoxication, inducing diuresis to remove edema, eliminating stagnation analgesic therapy, removing the necrotic tissue and promoting granulation, the dispel purpose of wart that reaching draws out pus by applying a plaster to the affected part.The present invention focuses on heat-clearing and toxic substances removing, detumescence and apocenosis; The stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, Radix Rhapontici in the side, cold in nature, the malignant boil poison of dispelling, the evacuation of pus of enriching blood, granulation promoting is put on flesh; The effect of clearing heat, releasing toxin, removing swelling evacuation of pus is arranged, be applicable to when the heavier outer diseases such as skin sore of pyretic toxicity are not suppurated, can subside a swelling; Can the evacuation of pus granulation promoting when becoming pus, be monarch drug.Fructus Bruceae, bitter in the mouth, cold in nature, poisonous is returned large intestine, Liver Channel.The function heat-clearing and toxic substances removing, dysentery relieving malaria, erosion wart." Chinese medicinal herbal " day " Fructus Bruceae cures mainly the wart wart "; Be ministerial drug.Radix Glycyrrhizae, the sweet temperature of property, coordinating the actions of various ingredients in a prescription, it can be in harmonious proportion the bias of various medicines, makes it to play a role better.Borneolum Syntheticum gas delicate fragrance, it is refrigerant to distinguish the flavor of, and function have one's ideas straightened out refreshment, clearing away heat to alleviate pain are kindly controlled conjunctival congestion and swelling pain, laryngopharynx swelling and pain, pathopyretic ulcer and the sore being festered and unhealed do not close up and sore throat aphtha, otitis media, carbuncle, hemorrhoid etc. for a long time.
The all medicines of the present invention share, and play heat-clearing and toxic substances removing altogether, the effect of wart of dispelling of drawing out pus by applying a plaster to the affected part, and external treatment focuses on to be eradicated the wart body and eliminate wart and inferior clinical symptom incubation period, thereby reaches the purpose of radical cure condyloma acuminatum.
Compared with the prior art the present invention has following advantage:
1, medicine of the present invention has no side effect.
2, patient's no pain easy to use, the more no cicatrix in back.
3, curative effect of medication of the present invention is fast, cures the fastest 5 days, and is average 8 days, the longest 15 days.
4, effect of drugs of the present invention is remarkable, and cure rate is up to 99.8%, and relapse rate is extremely low.
5, medicine of the present invention is applicable to various condyloma acuminatum.
The specific embodiment
Embodiment one:
A kind of medicine for the treatment of condyloma acuminatum, it is the medicament of being made by following raw materials by weight proportions:
Radix Rhapontici 15～38
Borneolum Syntheticum 1～5
Fructus Bruceae 5～25
Radix Glycyrrhizae 5～25;
The present embodiment medicament is an externally applied liniment.
Embodiment two:
A kind of medicine for the treatment of condyloma acuminatum, it is the medicament of being made by following raw materials by weight proportions:
Radix Rhapontici 20
Borneolum Syntheticum 1
Fructus Bruceae 10
Radix Glycyrrhizae 10;
The present embodiment medicament is an externally applied liniment.
The preparation method of embodiment one and embodiment two is:
A) take by weighing each crude drug by described weight ratio, and Borneolum Syntheticum powder is broken into fine powder, and to cross 80 mesh sieves standby;
B) with described Radix Rhapontici, Fructus Bruceae, Radix Glycyrrhizae, join in the container, add the ethanol of 240 grams, 70～80 ℃ of reflux, extract, 2 hours, leach for the first time extracting solution kept medicinal residues in another container;
C) will add the ethanol of 160 gram amounts in the described medicinal residues again, 70～80 ℃ of reflux, extract, 1.5 hours, leaching for the second time, medicinal liquid and first time medicinal liquid mixes;
D) described admixing medical solutions being concentrated into relative proportion is 1.10～1.15 (admixing medical solutions is 70 ℃), adds Borneolum Syntheticum, stirs, and leaves standstill 24 hours, filters out supernatant, makes externally applied liniment.
Using method: dip in thin cotton swab and to get a little liniment point and be applied to the wart surface, expose the skin ulcer face, treat this product drying after, free more movable, last medicine was a course of treatment in per 5 days, 1-3 the course of treatment of treatment of following the doctor's advice.
The present invention is based on the motherland Chinese medicine and learn, study intensively, selected antiinflammatory sterilization, sterilizing and itch-relieving, dampness analgesic Chinese medicine for use, promote the skin lesion reparation to reach, the purpose of wart of dispelling of drawing out pus by applying a plaster to the affected part through the scientific research personnel to pathogenetic understanding of condyloma acuminatum and Therapeutic Principle.
In the present embodiment, elite Radix Echinopsis, our Radix Echinopsis focuses on heat-clearing and toxic substances removing, detumescence and apocenosis; The stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis is a monarch drug; The java brucea seed counteracting toxic substances, heat-clearing and toxic substances removing, cooling blood for hemostasis is a ministerial drug; Radix Glycyrrhizae eliminating fire and detoxication, sensible eliminating carbuncle are messenger drug; All medicines share, and play heat clearing and damp drying altogether, removing toxic substances and promoting subsidence of swelling, the merit of the wart of dispelling.
Embodiment three:
A kind of medicine for the treatment of condyloma acuminatum, it is the medicament of being made by following raw materials by weight proportions:
Radix Rhapontici 15～38
Borneolum Syntheticum 1～5
Fructus Bruceae 5～25
Radix Glycyrrhizae 5～25
Spina Gleditsiae 25～38;
The present embodiment medicament is an externally applied liniment.
Embodiment four:
A kind of medicine for the treatment of condyloma acuminatum, it is the medicament of being made by following raw materials by weight proportions:
Radix Rhapontici 20 grams
Borneolum Syntheticum 1 gram
Fructus Bruceae 10 grams
Radix Glycyrrhizae 10 grams
Spina Gleditsiae 20 grams;
The present embodiment medicament is an externally applied liniment.
Embodiment three and embodiment four preparation methoies are:
A) take by weighing each crude drug by described weight ratio, and Borneolum Syntheticum powder is broken into fine powder, and to cross 80 mesh sieves standby;
B) with described Radix Rhapontici, Fructus Bruceae, Radix Glycyrrhizae, Spina Gleditsiae, join in the container, add the ethanol of 360 grams, 70～80 ℃ of reflux, extract, 2 hours, leach for the first time extracting solution kept medicinal residues in another container;
C) will add the ethanol of 240 gram amounts in the described medicinal residues again, 70～80 ℃ of reflux, extract, 1.5 hours, leaching for the second time, medicinal liquid and first time medicinal liquid mixes;
D) described admixing medical solutions being concentrated into relative proportion is 1.10～1.15 (admixing medical solutions is 70 ℃), adds Borneolum Syntheticum, stirs, and leaves standstill 24 hours, filters out supernatant, makes externally applied liniment.
Embodiment five:
A kind of medicine for the treatment of condyloma acuminatum, it is the medicament of being made by following raw materials by weight proportions:
Radix Rhapontici 15～38
Borneolum Syntheticum 1～5
Fructus Bruceae 5～25
Radix Glycyrrhizae 5～25
Spina Gleditsiae 25～38
Squama Manis 10～25;
The present embodiment medicament is an externally applied liniment, and described Squama Manis is for concocting the Squama Manis of handling.
Embodiment six:
Radix Rhapontici 20 grams
Borneolum Syntheticum 1 gram
Fructus Bruceae 10 grams
Radix Glycyrrhizae 10 grams
Spina Gleditsiae 20 grams
Squama Manis 15 grams;
The present embodiment medicament is an externally applied liniment, and described Squama Manis is for concocting the Squama Manis of handling.
Embodiment five and embodiment six preparation methoies are:
A) take by weighing each crude drug by described weight ratio, and Borneolum Syntheticum powder is broken into fine powder, and to cross 80 mesh sieves standby;
B) with described Radix Rhapontici, Fructus Bruceae, Radix Glycyrrhizae, Spina Gleditsiae, Squama Manis, join in the container, add the ethanol of 450 grams, 70～80 ℃ of reflux, extract, 2 hours, leach for the first time extracting solution kept medicinal residues in another container;
C) will add the ethanol of 300 gram amounts in the described medicinal residues again, 70～80 ℃ of reflux, extract, 1.5 hours, leaching for the second time, medicinal liquid and first time medicinal liquid mixes;
D) described filtrate being concentrated into relative proportion is 1.10～1.15 (admixing medical solutions is 70 ℃), adds Borneolum Syntheticum, stirs, and leaves standstill 24 hours, filters out supernatant, makes externally applied liniment.
Embodiment seven:
A kind of medicine for the treatment of condyloma acuminatum, it is the medicament of being made by following raw materials by weight proportions:
Radix Rhapontici 15～38
Borneolum Syntheticum 1～5
Fructus Bruceae 5～25
Radix Glycyrrhizae 5～25
Spina Gleditsiae 25～38
Squama Manis 10～25
Herba Portulacae 10～25
Semen Coicis 10～25;
The present embodiment medicament is an externally applied liniment, and described Squama Manis is for concocting the Squama Manis of handling.
Embodiment eight:
A kind of medicine for the treatment of condyloma acuminatum, it is the medicament of being made by following raw materials by weight proportions:
Radix Rhapontici 20 grams
Borneolum Syntheticum 1 gram
Fructus Bruceae 10 grams
Radix Glycyrrhizae 10 grams
Spina Gleditsiae 20 grams
Squama Manis 15 grams
Herba Portulacae 20 grams
Semen Coicis 25 grams;
The present embodiment medicament is an externally applied liniment, and described Squama Manis is for concocting the Squama Manis of handling.
Embodiment seven and embodiment eight preparation methoies are:
A) take by weighing each crude drug by described weight ratio, and Borneolum Syntheticum powder is broken into fine powder, and to cross 120 mesh sieves standby;
B) with described Radix Rhapontici, Fructus Bruceae, Radix Glycyrrhizae, Spina Gleditsiae, Squama Manis, Herba Portulacae, Semen Coicis, join in the container, add the ethanol of 750 grams, 70～80 ℃ of reflux, extract, 2 hours, leach for the first time extracting solution kept medicinal residues in another container;
C) will add the ethanol of 500 gram amounts in the described medicinal residues again, 70～80 ℃ of reflux, extract, 1.5 hours, leaching for the second time, medicinal liquid and first time medicinal liquid mixes;
D) described filtrate being concentrated into relative proportion is 1.10～1.15 (admixing medical solutions is 70 ℃), adds Borneolum Syntheticum, stirs, and leaves standstill 24 hours, filters out supernatant, makes externally applied liniment.
In the present embodiment, elite Radix Echinopsis, our Radix Echinopsis focuses on heat-clearing and toxic substances removing, detumescence and apocenosis; The stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis is a monarch drug; Java brucea seed counteracting toxic substances, Spina Gleditsiae are drawn out pus by applying a plaster to the affected part, heat-clearing and toxic substances removing, cooling blood for hemostasis; Be ministerial drug altogether, the spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus is an adjuvant drug; Radix Glycyrrhizae eliminating fire and detoxication, sensible eliminating carbuncle are messenger drug; Eight medicines share, and play heat clearing and damp drying altogether, removing toxic substances and promoting subsidence of swelling, the merit of the wart of dispelling.
Radix Rhapontici in the medicine of present embodiment, cold in nature, the malignant boil poison of dispelling, the evacuation of pus of enriching blood, granulation promoting is put on flesh; The effect of clearing heat, releasing toxin, removing swelling evacuation of pus is arranged, be applicable to when the heavier outer diseases such as skin sore of pyretic toxicity are not suppurated, can subside a swelling; Can the evacuation of pus granulation promoting when becoming pus, be monarch drug.Fructus Bruceae, bitter in the mouth, cold in nature, poisonous is returned large intestine, Liver Channel.The function heat-clearing and toxic substances removing, dysentery relieving malaria, erosion wart." Chinese medicinal herbal " day " Fructus Bruceae cures mainly the wart wart "; Spina Gleditsiae, warm in nature, kind can attack to loose have the effect of detumescence and apocenosis to be used for carbuncle sore tumefacting virus, not the made dissipation of Chenging, the impelled morning that becomes routed, the two is ministerial drug altogether.Squama Manis (processed product of Squama Manis) bitter in the mouth, liver, stomach, spleen, large intestine channel are returned in little salty cold, and it has anticancer, the detumescence and apocenosis of relieving internal heat, the silt eliminating stagnation of dispelling function; Herba Portulacae, cold in nature, the effect of the diffusing blood of heat-clearing and toxic substances removing parasite killing is arranged, can treat the carbuncle not all right to blood stasis; Semen Coicis, cold nature have the effect of strengthening the spleen and tonifying the lung, diuretic dehumidifying, heat clearing away toxin expelling to cure mainly the edema of rheumatism, joint contracture and water-damp retention; Spleen invigorating eliminating dampness by diuresis, clearing away heat and discharging pus are adjuvant drug altogether.Radix Glycyrrhizae, the sweet temperature of property, coordinating the actions of various ingredients in a prescription, it can be in harmonious proportion the bias of various medicines, makes it to play a role better.
The present invention has carried out relevant animal experiment study in experimental animal portion of Chinese Medical Sciences University, and the result of study proof the present invention have no side effect, and medicine of the present invention can be treated condyloma acuminatum safely and effectively.Below be the report summaries of medicament dermatologic of the present invention acute toxicity test:
One, purpose: observe the toxic reaction that animal intact skin and damaged skin short-term contact " medicament of the present invention " are produced.
Two, animal and material:
(1) animal
1, kind: New Zealand white rabbit (New Zealan white);
2, body weight: about 2Kg;
3, sex: male and female half and half;
4, the age: adult healthy;
5, number of animals: 30
(2) tried thing
1, tried thing: the present invention treats the medicament of condyloma acuminatum
2, source: the precious bio tech ltd of Shenyang China
3, content: 6.0g/ml
(3) route of administration:
1, the making of damaged skin behind the skin depilatory: with sand paper with sterilize skin galling of unhairing, degree of being with the oozing of blood.
2, " medicament of the present invention " solution directly is applied in the test depilation skin place that is tried thing.
Three, test method:
1, animal grouping: animal is divided into 5 groups, 6 of every group of New Zealand white rabbit, male and female half and half, totally 30.One group is matched group, and four groups is test group (intact skin group and damaged skin group, each two dosage); Low dose group is 6g/ml, and high dose group is 4 times of low dose group, is 24g/ml.
2, skin coating:
(1) matched group: smear 95% ethanol liquid
(2) low dose group: " medicament of the present invention " solution (6g/ml) 0.5ml is spread upon the intact skin group of having lost hair or feathers and the test skin region of damaged skin group respectively;
(3) high dose group: " medicament of the present invention " solution (24g/ml) 0.5ml spreads upon the intact skin group of having lost hair or feathers and the test skin region of damaged skin group respectively.
" medicament of the present invention " solution (6g/ml) 0.5ml is spread upon the intact skin group of having lost hair or feathers and the test skin region of damaged skin group; By increasing the medication number of times, promptly smear 4 times (noting: smear next time again after each the doing) continuously and reach high dose concentration.
The test depilation skin region that is tried thing is evenly smeared " medicament of the present invention " solution, and tie up lid, use immobilization with adhesive tape with the nonirritant sterile gauze.
3, observing time and index:
To observe continuously 14 days after the animal subject administration.Behind the animals administer 24 hours, remove the residual reagent thing that is subjected to, remove and be subjected to behind the reagent thing 1 with warm water, 24,48,72 hours to 14 days, other poisoning manifestations such as the variation of body weight, skin, eye and the conjunctiva of observation every day and record animal, breathing, central nervous system, extremity activity.After the off-test animal is all put to death, and carry out pathological anatomy, histopathologic examination.
Four, test report and evaluation of result
1, animal grouping see Table 1,
Table 1, experimental animal grouping and body weight change
Animal dead does not take place at duration of test.Body weight change between each test group and matched group and each test group is learned by statistics and is handled P＞0.05, no significant difference.
2, the experimental animal effects on physiological indexes sees Table
(1) variation of table 2-1, experimental animal outward appearance, behavioral activity, the mental status
Animal appearance between each test group and matched group and each test group, behavioral activity, mental status no change.
(2) table 2-2, experimental animal breathing, appetite, defecation, variation
Animal breath between each test group and matched group and each test group, appetite, large and small just amount and the equal no change of color thereof.
(3) variation of table 2-3, experimental animal nose, eye, oral secretion
Animal nose between each test group and matched group and each test group, eye, oral secretion no change.
(4) variation of table 2-4, experimental animal skin
Animal skin between each test group and matched group and each test group p＜0.05 that is changed significantly.
Interpretation of result:
1. matched group: after smearing 95% ethanol liquid, any untoward reaction does not appear in skin.
2. low dosage intact skin group: 24 hours skin of medication occurs slight red and swollen, does not have and oozes out and vesicle; Skin continued slight red and swollen in 48 hours; Skin still continued slight red and swollen in 72 hours; Red swelling of the skin faded in 5 days; Red swelling of the skin faded in 7 days, surperficial atrophy; Skin surface was slightly formed a scab in 10 days; The slight incrustation of skin surface in 15 days comes off.
3. high dose intact skin group: 24 hours skin of medication occurs red and swollen, has and oozes out and phlysis; Skin continued redness in 48 hours, and have and ooze out on a small quantity and 10 several vesicles, the about 0.1mm of vesicle size; Skin still continued slight redness in 72 hours, and the vesicle that has is ulceration, no purulent secretion; Red swelling of the skin faded in 5 days, and nothing is oozed out, and vesicle becomes dry; Red swelling of the skin faded in 7 days, surperficial atrophy; Skin surface incrustation in 10 days; Skin surface incrustation in 15 days comes off.
4. low dosage damaged skin group: 24 hours skin of medication occurs slight red and swollen, slightly oozes out and vesicle; 48 hours lasting rednesses of skin are oozed out and vesicle gradually weighs; Skin still continued slight redness in 72 hours, oozed out and vesicle; Red swelling of the skin faded in 5 days; Red swelling of the skin faded in 7 days, surperficial atrophy; Skin surface was slightly formed a scab in 10 days; Skin surface incrustation in 15 days comes off.
5. high dose damaged skin group: 24 hours skin of medication occurs red and swollen, has and oozes out and phlysis; 48 hours lasting rednesses of skin are oozed out and vesicle gradually weighs; Skin still continued redness in 72 hours, oozed out and vesicle; Skin continued redness in 5 days, and the vesicle ulceration has and oozes out, no purulent secretion; Red swelling of the skin faded in 7 days, and nothing is oozed out, ulceration position desiccation; Red swelling of the skin disappeared in 10 days, the surface incrustation; Skin surface incrustation in 15 days comes off.
3, pathological anatomy, histopathologic examination
(1) pathological anatomy inspection:
After the off-test, put to death animal, dissect, macroscopy as seen: the heart, liver, lung, spleen, pancreas, kidney, stomach, intestinal, brain, thymus, adrenal gland, hypophysis and non-test skin region are all normal.
(2) test dermal pathology histological examination:
Low dosage intact skin group: no acute injury, do not stay cicatrix after healing;
High dose intact skin group: no acute injury, do not stay cicatrix after healing;
Low dosage damaged skin group: no acute injury, do not stay cicatrix after healing;
High dose damaged skin group: no acute injury, do not stay cicatrix after healing.
4, evaluation of result
(1), " medicine of the present invention " solution (6g/ml) is slight to rabbit low dosage intact skin group toxicity, damage epidermis and subcutaneous tissue do not have the abnormal pigmentary deposit on the skin trace after the healing.
(2), " medicine of the present invention " solution (24g/ml) is heavier to rabbit high dose intact skin group toxicity, the no abnormal pigmentary deposit on the skin trace in healing back.
(3), " medicine of the present invention " solution (6g/ml) is slight to rabbit low dosage damaged skin group toxicity, damage epidermis and subcutaneous tissue do not have the abnormal pigmentary deposit on the skin trace after the healing.
(4), " medicine of the present invention " solution (24g/ml) is heavier to rabbit high dose damaged skin group toxicity, damage epidermis and subcutaneous tissue do not reach skin corium, the slight abnormal pigmentary deposit on the skin trace in healing back.
Curative effect of the present invention:
The present invention is through 1100 routine clinic trial, wherein male 590 people, women 510 people, age 18-65 year.The present invention 5 days was a course of treatment, and 1100 routine patients are through a course of therapy, wart body recovery from illness 792 people that come off fully, and cure rate is 72.0%; All the other patients are after two courses of treatment, 148 people that fully recover again, and after cure rate reached 85.5%, three course of treatment, remaining patient had 158 people to cure, two people's poor effect only, cure rate almost reaches 100% effect up to 99.8%.For curative effect of the present invention is described, it is as follows to enumerate some cases:
Model case
1, Jiang, the woman, 32 years old, the superfluous sample proliferation of patient's anus and vagina 8 months, with lower abdominal pain, leucorrhoea grow in quantity, the yellow skin flavor is smelly, is diagnosed as condyloma acuminatum, and is invalid through multi-treatment.Through using medicine of the present invention four times, the wart body all comes off, and the skin lesion reparation is good.Follow up a case by regular visits to and do not have recurrence in 1 year.
2, Chen, the man, 51 years old, patient's penis had several pieces of superfluous sample proliferations, and the white test of acetic acid shows positive, and the lab testing HPV positive is diagnosed as condyloma acuminatum.Through using medicine twice of the present invention, the wart body all comes off, and the skin lesion reparation is good.Follow up a case by regular visits to and do not have recurrence in 1 year.
3, river, the woman, 30 years old, patient's pudendum had four pieces of superfluous sample proliferations, has pruritus painless, and with a small amount of leucorrhea, the white test of acetic acid shows positive, and the lab testing HPV positive is diagnosed as condyloma acuminatum.Through using medicine of the present invention once, the wart body all comes off, and the skin lesion reparation is good.Follow up a case by regular visits to and do not have recurrence in five months.
4, Wu, the woman, 24 years old, patient's pudendum had 12 pieces of superfluous sample proliferations 3 months, Semen setariae was arranged approximately to Semen Glycines sample size, and surperficial taupe is mamillary, companion's leucorrhoea grow in quantity, the white test of acetic acid shows positive, and the lab testing HPV positive is diagnosed as condyloma acuminatum.Through using medicine of the present invention once, the wart body all comes off, and the skin lesion reparation is good.Follow up a case by regular visits to and do not have recurrence in six months.
5, the summer, the woman, 51 years old, patient's pudendum and vagina had superfluous sample proliferation 1 month, and with pruritus, the white test of acetic acid shows positive, and the lab testing HPV positive is diagnosed as condyloma acuminatum.Through using medicine of the present invention once, the wart body all comes off, and the skin lesion reparation is good.Follow up a case by regular visits to and do not have recurrence in eight months.
6, Lin, the man, 38 years old, 10 pieces of superfluous sample proliferations of patient's prepuce of penis 1 month, moving easily hemorrhage with pruritus, the white test of acetic acid shows positive, and the lab testing HPV positive is diagnosed as condyloma acuminatum.Through using medicine twice of the present invention, the wart body all comes off, and the skin lesion reparation is good.Follow up a case by regular visits to and do not have recurrence in 1 year.
7, Wu, the man, 20 years old, the superfluous sample proliferation in patient's penis coronary sulcus place 1 month, the cockscomb shape, pink, moving easily hemorrhage with pruritus, the white test of acetic acid shows positive, and the lab testing HPV positive is diagnosed as condyloma acuminatum.Through using medicine of the present invention once, the wart body all comes off, and the skin lesion reparation is good.Follow up a case by regular visits to and do not have recurrence in 14 months.
8, Dong, the man, 25 years old, 12 pieces of the superfluous sample proliferations of patient's scrotum both sides and groin, the surface is the pimple shape, and pink is moving easily hemorrhage, and the white test of acetic acid shows positive, and the lab testing HPV positive is diagnosed as condyloma acuminatum.Through using medicine of the present invention once, the wart body all comes off, and the skin lesion reparation is good.Follow up a case by regular visits to and do not have recurrence in 1 year.
9, Liu, the woman, 18 years old, patient's labium majus sample proliferation of going to live in the household of one's in-laws on getting married, lamellar is intensive, about Semen setariae sample size, mamillary, the white test of acetic acid shows positive, and the lab testing HPV positive is diagnosed as condyloma acuminatum.Through using medicine of the present invention three times, the wart body all comes off, and the skin lesion reparation is good.Follow up a case by regular visits to and do not have recurrence in three months.
10, Wu, the man, 40 years old, there was superfluous sample proliferation one month at patient's scrotum place, about Semen Glycines size, cauliflower form, the white test of acetic acid shows positive, and the lab testing HPV positive is diagnosed as condyloma acuminatum.Through using medicine twice of the present invention, the wart body all comes off, and the skin lesion reparation is good.Follow up a case by regular visits to and do not have recurrence in four months.
11, Wang, man, 38 years old, patient's coronary sulcus ring-type, about 3cm wart body; One piece of cauliflower form wart of urethral orifice body; It is block that anus is, cauliflower form, and 10cm * 6cm wart body, the white test of acetic acid shows positive, and the lab testing HPV positive is diagnosed as condyloma acuminatum.This case is the rare huge condyloma latum in the world.Through using medicine twice of the present invention, coronary sulcus and urethral orifice wart body all come off, and the skin lesion reparation is good; 2/3 wart body has been eliminated at the anus place.
Claims (8)
1. externally applied liniment for the treatment of condyloma acuminatum, it is characterized in that: it is the medicament of being made by following raw materials by weight proportions;
Radix Rhapontici 15～38
Borneolum Syntheticum 1～5
Fructus Bruceae 5～25
Radix Glycyrrhizae 5～25;
Preparation process is as follows:
A) take by weighing each crude drug by described weight ratio, and Borneolum Syntheticum powder is broken into fine powder, and to cross 80 mesh sieves standby;
B) with described Radix Rhapontici, Fructus Bruceae, Radix Glycyrrhizae, join in the container, add the ethanol of 240 grams, 70～80 ℃ of reflux, extract, 2 hours, leach for the first time extracting solution kept medicinal residues in another container;
C) will add the ethanol of 160 gram amounts in the described medicinal residues again, 70～80 ℃ of reflux, extract, 1.5 hours, leaching for the second time, medicinal liquid and first time medicinal liquid mixes;
D) described admixing medical solutions being concentrated into relative proportion is 1.10～1.15, and admixing medical solutions is 70 ℃, adds Borneolum Syntheticum, stirs, and leaves standstill 24 hours, filters out supernatant, makes externally applied liniment.
2. externally applied liniment according to claim 1, wherein the weight proportion of each crude drug is:
Radix Rhapontici 20
Borneolum Syntheticum 1
Fructus Bruceae 10
Radix Glycyrrhizae 10.
3. externally applied liniment for the treatment of condyloma acuminatum, it is characterized in that: it is the medicament of being made by following raw materials by weight proportions;
Radix Rhapontici 15～38
Borneolum Syntheticum 1～5
Fructus Bruceae 5～25
Radix Glycyrrhizae 5～25
Spina Gleditsiae 25～38;
Preparation process is as follows:
A) take by weighing each crude drug by described weight ratio, and Borneolum Syntheticum powder is broken into fine powder, and to cross 80 mesh sieves standby;
B) with described Radix Rhapontici, Fructus Bruceae, Radix Glycyrrhizae, Spina Gleditsiae, join in the container, add the ethanol of 360 grams, 70～80 ℃ of reflux, extract, 2 hours, leach for the first time extracting solution kept medicinal residues in another container;
C) will add the ethanol of 240 gram amounts in the described medicinal residues again, 70～80 ℃ of reflux, extract, 1.5 hours, leaching for the second time, medicinal liquid and first time medicinal liquid mixes;
D) described admixing medical solutions being concentrated into relative proportion is 1.10～1.15, and admixing medical solutions is 70 ℃, adds Borneolum Syntheticum, stirs, and leaves standstill 24 hours, filters out supernatant, makes externally applied liniment.
4. externally applied liniment for the treatment of condyloma acuminatum, it is characterized in that: it is the medicament of being made by following raw materials by weight proportions:
Radix Rhapontici 20
Borneolum Syntheticum 1
Fructus Bruceae 10
Radix Glycyrrhizae 10
Spina Gleditsiae 20;
A) take by weighing each crude drug by described weight ratio, and Borneolum Syntheticum powder is broken into fine powder, and to cross 80 mesh sieves standby;
B) with described Radix Rhapontici, Fructus Bruceae, Radix Glycyrrhizae, Spina Gleditsiae, join in the container, add the ethanol of 360 grams, 70～80 ℃ of reflux, extract, 2 hours, leach for the first time extracting solution kept medicinal residues in another container;
C) will add the ethanol of 240 gram amounts in the described medicinal residues again, 70～80 ℃ of reflux, extract, 1.5 hours, leaching for the second time, medicinal liquid and first time medicinal liquid mixes;
D) described admixing medical solutions being concentrated into relative proportion is 1.10～1.15, and admixing medical solutions is 70 ℃, adds Borneolum Syntheticum, stirs, and leaves standstill 24 hours, filters out supernatant, makes externally applied liniment.
5. externally applied liniment for the treatment of condyloma acuminatum, it is characterized in that: it is the medicament of being made by following raw materials by weight proportions;
Radix Rhapontici 15～38
Borneolum Syntheticum 1～5
Fructus Bruceae 5～25
Radix Glycyrrhizae 5～25
Spina Gleditsiae 25～38
Squama Manis 10～25;
Preparation process is as follows:
A) take by weighing each crude drug by described weight ratio, and Borneolum Syntheticum powder is broken into fine powder, and to cross 80 mesh sieves standby;
B) with described Radix Rhapontici, Fructus Bruceae, Radix Glycyrrhizae, Spina Gleditsiae, Squama Manis, join in the container, add the ethanol of 450 grams, 70～80 ℃ of reflux, extract, 2 hours, leach for the first time extracting solution kept medicinal residues in another container;
C) will add the ethanol of 300 gram amounts in the described medicinal residues again, 70～80 ℃ of reflux, extract, 1.5 hours, leaching for the second time, medicinal liquid and first time medicinal liquid mixes;
D) described filtrate being concentrated into relative proportion is 1.10～1.15, and admixing medical solutions is 70 ℃, adds Borneolum Syntheticum, stirs, and leaves standstill 24 hours, filters out supernatant, makes externally applied liniment.
6. externally applied liniment for the treatment of condyloma acuminatum, it is characterized in that: it is the medicament of being made by following raw materials by weight proportions;
Radix Rhapontici 20
Borneolum Syntheticum 1
Fructus Bruceae 10
Radix Glycyrrhizae 10
Spina Gleditsiae 20
Squama Manis 15;
Preparation process is as follows:
A) take by weighing each crude drug by described weight ratio, and Borneolum Syntheticum powder is broken into fine powder, and to cross 80 mesh sieves standby;
B) with described Radix Rhapontici, Fructus Bruceae, Radix Glycyrrhizae, Spina Gleditsiae, Squama Manis, join in the container, add the ethanol of 450 grams, 70～80 ℃ of reflux, extract, 2 hours, leach for the first time extracting solution kept medicinal residues in another container;
C) will add the ethanol of 300 gram amounts in the described medicinal residues again, 70～80 ℃ of reflux, extract, 1.5 hours, leaching for the second time, medicinal liquid and first time medicinal liquid mixes;
D) described filtrate being concentrated into relative proportion is 1.10～1.15, and admixing medical solutions is 70 ℃, adds Borneolum Syntheticum, stirs, and leaves standstill 24 hours, filters out supernatant, makes externally applied liniment.
7. externally applied liniment for the treatment of condyloma acuminatum, it is characterized in that: it is the medicament of being made by following raw materials by weight proportions;
Radix Rhapontici 15～38
Borneolum Syntheticum 1～5
Fructus Bruceae 5～25
Radix Glycyrrhizae 5～25
Spina Gleditsiae 25～38
Squama Manis 10～25
Herba Portulacae 10～25
Semen Coicis 10～25;
Preparation process is as follows:
A) take by weighing each crude drug by described weight ratio, and Borneolum Syntheticum powder is broken into fine powder, and to cross 120 mesh sieves standby;
B) with described Radix Rhapontici, Fructus Bruceae, Radix Glycyrrhizae, Spina Gleditsiae, Squama Manis, Herba Portulacae, Semen Coicis, join in the container, add the ethanol of 750 grams, 70～80 ℃ of reflux, extract, 2 hours, leach for the first time extracting solution kept medicinal residues in another container;
C) will add the ethanol of 500 gram amounts in the described medicinal residues again, 70～80 ℃ of reflux, extract, 1.5 hours, leaching for the second time, medicinal liquid and first time medicinal liquid mixes;
D) described filtrate being concentrated into relative proportion is 1.10～1.15, and admixing medical solutions is 70 ℃, adds Borneolum Syntheticum, stirs, and leaves standstill 24 hours, filters out supernatant, makes externally applied liniment.
8. externally applied liniment for the treatment of condyloma acuminatum, it is characterized in that: it is the medicament of being made by following raw materials by weight proportions;
Radix Rhapontici 20
Borneolum Syntheticum 1
Fructus Bruceae 10
Radix Glycyrrhizae 10
Spina Gleditsiae 20
Squama Manis 15
Herba Portulacae 20
Semen Coicis 25;
A) take by weighing each crude drug by described weight ratio, and Borneolum Syntheticum powder is broken into fine powder, and to cross 120 mesh sieves standby;
B) with described Radix Rhapontici, Fructus Bruceae, Radix Glycyrrhizae, Spina Gleditsiae, Squama Manis, Herba Portulacae, Semen Coicis, join in the container, add the ethanol of 750 grams, 70～80 ℃ of reflux, extract, 2 hours, leach for the first time extracting solution kept medicinal residues in another container;
C) will add the ethanol of 500 gram amounts in the described medicinal residues again, 70～80 ℃ of reflux, extract, 1.5 hours, leaching for the second time, medicinal liquid and first time medicinal liquid mixes;
D) described filtrate being concentrated into relative proportion is 1.10～1.15, and admixing medical solutions is 70 ℃, adds Borneolum Syntheticum, stirs, and leaves standstill 24 hours, filters out supernatant, makes externally applied liniment.
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| CN2006100761046A CN101062085B (en) | 2006-04-26 | 2006-04-26 | Condyloma acuminata treating medicine |
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| CN2006100761046A CN101062085B (en) | 2006-04-26 | 2006-04-26 | Condyloma acuminata treating medicine |
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| CN103405646B (en) * | 2013-08-04 | 2014-08-13 | 张珍平 | TCM composition for treating recurrent-attack senile vaginitis |
| CN103623285A (en) * | 2013-11-25 | 2014-03-12 | 青岛大学医学院附属医院 | Medicinal composition for treating condyloma acuminata |
| CN103800684A (en) * | 2014-03-05 | 2014-05-21 | 林仁耳 | Radical operation for treating cervical human papillomavirus (HPV), cervical intraepithelial neoplasia (CIN) and cervical erosion by synchronous external use of traditional Chinese medicines and Western medicines |
| CN115957281A (en) * | 2022-12-28 | 2023-04-14 | 芙蓉定王台门诊部 | A Chinese medicinal powder for treating condyloma acuminatum, and its preparation method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1072853A (en) * | 1992-07-07 | 1993-06-09 | 徐福祥 | Production method for mammary cancer panacea |
| CN1276225A (en) * | 2000-05-17 | 2000-12-13 | 涂宏海 | 'Chanhoukang' for postpartum recovery and its preparing process |
| CN1410122A (en) * | 2002-11-27 | 2003-04-16 | 荣文舟 | Chinese medicine preparation for treating acute condyloma |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1072853A (en) * | 1992-07-07 | 1993-06-09 | 徐福祥 | Production method for mammary cancer panacea |
| CN1276225A (en) * | 2000-05-17 | 2000-12-13 | 涂宏海 | 'Chanhoukang' for postpartum recovery and its preparing process |
| CN1410122A (en) * | 2002-11-27 | 2003-04-16 | 荣文舟 | Chinese medicine preparation for treating acute condyloma |
Non-Patent Citations (4)
| Title |
|---|
| 郭随章，薛志均.***的中药治疗.时珍国医国药9 4.1998,9(4),第301页. |
| 郭随章,薛志均.***的中药治疗.时珍国医国药9 4.1998,9(4),第301页. * |
| 项励，蒋文跃.中医治疗***的进展.辽宁中医杂志27 5.2000,27(5),第832页. |
| 项励,蒋文跃.中医治疗***的进展.辽宁中医杂志27 5.2000,27(5),第832页. * |
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