CN101024066A - Jinsangliyan preparation and preparing method - Google Patents
Jinsangliyan preparation and preparing method Download PDFInfo
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Abstract
The present invention relates to a Chinese medicine Jinsang Liyan preparation for relieving sore-throat and diminishing swelling with obvious therapeutic effect. Said Chinese medicine is made up by using 17 Chinese medicinal materials of poria, pro formula pinellia tuber, urripe bitter orange, unripe tangerine peel, bile-processed arisaema root and others through a certain preparation process. Said Chinese medicine can be made into concentrated pill, granules preparation, tablet, soft capsule and lozenge, etc.
Description
Affiliated technical field: the invention belongs to Chinese medicine novel form and preparation method thereof, specifically is a kind of 'Jinsang Liyan ' and preparation method thereof.Described preparation is meant Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule.
Background technology: existing Jinsangliyan prescription has depressed liver-energy dispersing and QI regulating, the effect of the sore-throat relieving that reduces phlegm.Be used for phlegm resistance, the foreign body in pharynx sense due to the stagnation of QI due to depression of the liver, pharyngeal discomfort, hoarseness, pachyderma circumscripta are seen above-mentioned disease person.Existing dosage form has only the Jinsangliyan ball, comprises two kinds of water-honeyed pill, big honeyed pills.Because of this side's determined curative effect, list " one one of Chinese pharmacopoeia version in 2005 in.The water-honeyed pill of existing dosage form is that all pulverizing medicinal materials are become fine powder with big honeyed pills and preparation method thereof, sieves then, and mixing is made water-honeyed pill or big honeyed pills.
Existing dosage form and preparation method thereof is traditional dosage form and a method for making for many years, has following shortcoming:
1, dose is bigger, the difficulty of swallowing: the heavy 1g of per 10 balls of the water-honeyed pill of for example making, oral one time 60～120 ball; The heavy 9g of the every ball of big honeyed pills, oral one time 1～2 ball is unfavorable for that especially child, old people and dysphagia person take;
2, medicine disintegrate, absorption are slow, bioavailability is low: because of water-honeyed pill, big honeyed pills are used as medicine for the vegetalitas powder entirely, the effective ingredient major part is wrapped in the cell that is not broken up as yet in the powder, will pass through processes such as disintegrate, stripping, absorption after oral, onset is slower;
3, be easy to damage by worms and go mouldy: honeyed pill particularly, because of containing a large amount of refined honeys, easily by germ contamination etc.;
4, packing is difficult for mechanization: honeyed pill paraffin paper packing commonly used, though but machinery production wax shell, mechanization degree is not high during packing;
Thereby existing dosage form brings great inconvenience for clinical practice and industrialized mass.
The objective of the invention is in order to overcome the above-mentioned defective of prior art, for people provide a kind of have the drug utilization degree better, rapid-action, help 'Jinsang Liyan ' of characteristics such as clinical practice and industrialized mass and preparation method thereof, described preparation comprises Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule.
The objective of the invention is to realize by following technical proposals.
Summary of the invention: 'Jinsang Liyan ' of the present invention, form by following raw materials by weight percent: Poria, Rhizoma Pinelliae Preparatum, Fructus Aurantii Immaturus (stir-fry), Pericarpium Citri Reticulatae Viride (stir-fry), Arisaema Cum Bile, dried tangerine peel, Fructus Amomi, Semen Arecae, Cortex Albiziae, Massa Medicata Fermentata (stir-fry), Caulis Perillae, Periostracum Cicadae, Semen Oroxyli, Cortex Magnoliae Officinalis (system) each 3～10%, Fructus Amomi Rotundus 1～6%, Rhizoma Zingiberis Recens 0.2～2%, processes becomes concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule routinely.
In the such scheme, the preferable percentage by weight of described raw material be Poria, Rhizoma Pinelliae Preparatum, Fructus Aurantii Immaturus (stir-fry), Pericarpium Citri Reticulatae Viride (stir-fry), Arisaema Cum Bile, dried tangerine peel, Fructus Amomi, Semen Arecae, Cortex Albiziae, Massa Medicata Fermentata (stir-fry), Caulis Perillae, Periostracum Cicadae, Semen Oroxyli, Cortex Magnoliae Officinalis (system) each 6.83%, Fructus Amomi Rotundus 3.41%, Rhizoma Zingiberis Recens 1.03%.
The preparation method of 'Jinsang Liyan ' of the present invention be according to above-mentioned raw materials medical material character characteristics separately will be wherein the extract of part material medical material with wherein the protogenic medicinal powder and the additive of part material medical material are mixed and made into above-mentioned required dosage form, the extract of described medical material is meant the effective ingredient that adopts one or more extracting method to extract with a kind of raw material, and described additive is adjuvant, excipient, additives.Extracting method comprises that water is carried or other solvent extraction.
In the such scheme, described extract accounts for 60～100% of said medicine constituent gross weight.The granular size of described protogenic medicinal powder is 80～160 purpose fine powders or 200～300 purpose superfine powder.
In the such scheme, described extracting method adopts following principle to carry out according to raw medicinal material character characteristics separately:
Few valuable medicine, the malicious drastic of 1 starch-containing more medical material, consumption, some contains a small amount of fragrant volatile ingredient medical material and some mineral drug directly is ground into fine powder, i.e. protogenic medicinal powder.
But 2, contain also extracting section volatile ingredient of the more medical material of volatile ingredient, as volatile oil.
3, fibre-bearing is more, viscosity is bigger or scleroid medical material, adopts the decocting effective component extracting.
44, contain pure soluble components, available different concentration ethanol effective component extracting.
5, effective ingredient had both contained water soluble ingredient in the medicine, contained liposoluble constituent again, then according to the not same-action that its effective ingredient rose, can adopt the extraction of part decocting, part ethanol extraction.
6, the clear and definite person of effective ingredient can adopt the specific method effective component extracting according to the effective ingredient characteristic.
In the such scheme, the extracting solution that described decocting extracts or ethanol extraction obtained be condensed into relative density be 1.03～1.05 clear paste or be condensed into relative density be 1.05～1.40 soak (thick) cream, gained soak (thick) cream, get fine powder or superfine powder by drying, and then adopt routine techniques and the molding of additive hybrid process.
In the such scheme, described medicinal liquid concentrates and is preferably concentrating under reduced pressure; Soak the dry best vacuum drying/spray drying that is of (thick) cream, the vacuum drying temperature is controlled at 50～80 ℃, and the best is 60 ℃; The spray drying inlet temperature is 100～200 ℃, and leaving air temp is 50～150 ℃, and best inlet temperature is 150～180 ℃, and leaving air temp is 80～100 ℃, all can significantly reduce loss of active ingredients.
In the such scheme, get Arisaema Cum Bile, each 50-100% of Fructus Amomi, Poria 0-50%, be ground into fine powder, sieve, mixing, standby; Fructus Aurantii Immaturus (stir-fry), Pericarpium Citri Reticulatae Viride (stir-fry), tangerine each 50-100% extract volatile oil, collect volatile oil, preserve, and be standby; All the other ten medical materials simply decoct with water secondary, filter, and merging filtrate is concentrated into the thick paste shape, and is standby; Above-mentioned thick paste is put cold, added ethanol, make to contain the alcohol amount and reach 50～85%, leave standstill, get supernatant, reclaim ethanol, medicinal liquid is standby; Then above-mentioned fine powder, volatile oil, medicinal liquid are processed into required dosage form.
The Jinsangliyan novel formulation, comprise the Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule, used excipient in its preparation method, adjuvant, additives can be: Mel (refined honey), water, wine, vinegar, sucrose, gelatin, river wax, the Cinnabaris powder, Pulvis Talci, Realgar powder, the Indigo Naturalis powder, BAICAO powder, Lapis Micae Aureus powder or other coating materials, aluminium hydroxide, the gel powder, calcium carbonate, calcium hydrogen phosphate, calcium glycerophosphate, magnesium oxide, magnesium carbonate, beta-schardinger dextrin-, the hydroxyl beta-schardinger dextrin-, starch, dextrin, ethanol, polyvidone k30, micropowder silica gel, steviosin (sugar), Aspartane, magnesium stearate, microcrystalline Cellulose, carboxymethyl starch sodium, sodium carboxymethyl cellulose, pregelatinized Starch, soluble starch, hyprolose, lactose, protein sugar, calcium sulfate, silicon dioxide, carboxymethyl starch sodium, essence, glycerol, sorbitol, PGE400, oil with hydrogenated soybean, Cera Flava, any/multiple mixing in each vegetable oil is used.
The present invention is the technical scheme that the inventor passes through the science practicality that years of researches obtain, it has broken the constraint of traditional view, make novel formulation and preparation method thereof not only overcome the deficiency of present existing water-honeyed pill, big honeyed pills agent and preparation method thereof, and have following advantage:
1, dose is little and taking dose is accurate, and convenient the use: the adjuvant of interpolation is few, and the novel formulation dosage after making is controlled easily, and difference is little, and the novel formulation dose is few and easy to carry, and granule especially is beneficial to child, old people and dysphagia person and takes;
2, disintegrate, absorption, rapid-action, the bioavailability height, steady quality, ensure clinical efficacy: according to different medical material character in the prescription take respectively to pulverize, extract, concentrate, method such as drying, reduce loss of active ingredients to greatest extent, make more science, reasonable of preparation method, medical material has improved the effective ingredient intake after extracting:
For example tangerine main effective ingredient is its volatile oil, only depend on the method for pulverizing to extract, thereby adopt special-purpose extractive technique can obtain pure volatile oil, drug effect is better, consumption reduces, and the tangerine flower of a part can be obtained other tangerine aqueous soluble active constituents with decocting in water.The processing of other medicines composition can be by that analogy.
In addition, extracting solution adopts concentrating under reduced pressure to become extractum, to concentrate back extractum employing and be spray dried to the cream powder, drying time is short, effective ingredient is not easy to be damaged in dry run, and because of using the adjuvant amount few, has reduced the pollution of antibacterial, and the novel formulation of making is easy to sterilization, and shortened disintegrate, dissolution time; It is directly molten diffusing that the granule of making is taken the no disintegrating procedue in back, absorb fast, pill, tablet, soft capsule disintegration time pharmacopeia regulation are no more than 1 hour, the concentrated pill that new method makes, tablet, soft capsule then can be controlled in 0.5 hour, the dispersible tablet disintegration time then can be controlled in 3 minutes, can be with the detection index of dissolution as quality standard;
3, novel formulation all can adopt modern advanced production, packaging facilities and technology, and immediate packaging materials all can adopt the packaging material that meet national medicinal standard, and the mechanization degree height is beneficial to the mechanization mass industrialized production.
4, novel formulation comprises the invention of Jinsangliyan concentrated pill, Jinsangliyan granule, Jinsangliyan sheet, Jinsangliyan dispersible tablet, Jinsangliyan buccal tablet, Jinsangliyan soft capsule, also having enriched kind dosage form and clinical application selects, uses, made things convenient for extensive patients, can satisfy and ensure people's medication demand better, and the control criterion that when making novel formulation, improves the quality, can better control product quality, guarantee drug safety, effective, for vast because of phlegm resistance, foreign body in pharynx sense due to the stagnation of QI due to depression of the liver, pharyngeal discomfort, hoarseness; The patient of diseases such as pachyderma circumscripta benefits.
The invention is further illustrated by the following examples.The present invention is not limited only to described embodiment.
The specific embodiment:
Embodiment one
Prepare the Jinsangliyan novel formulation according to the following steps, comprise concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule:
Get Poria 210g, Rhizoma Pinelliae Preparatum 200g, Fructus Aurantii Immaturus (stir-fry) 120g, Pericarpium Citri Reticulatae Viride (stir-fry) 100g, Arisaema Cum Bile 185g, tangerine 100g, Fructus Amomi 100g, Fructus Amomi Rotundus 90g, Semen Arecae 120g, Cortex Albiziae 200g, Massa Medicata Fermentata (stir-fry) 120g, Caulis Perillae 100g, Rhizoma Zingiberis Recens 15g, Periostracum Cicadae 186g, Semen Oroxyli 110g, Cortex Magnoliae Officinalis (system) 120g, standby;
Get Poria 110g, Fructus Amomi 55g, Arisaema Cum Bile 95 in A, the above medicine, be ground into fine powder, sieve, mixing, standby;
The surplus of B, all the other flavour of a drug and above-mentioned three flavor medicines decocts with water secondary, and each 1～3 hour, collecting decoction filters, and gets filtrate, and was standby;
C, filtrate is concentrated into relative density is 1.03～1.05 clear paste; Or medicinal liquid is concentrated into the thick paste that relative density is 1.28～1.32 (85 ℃); Or filtrate is concentrated into the extractum that relative density is 1.03～1.20 (85 ℃), be dried to powder;
D, with above-mentioned cream or cream powder and fine powder mixing, add suitable excipient, make the spheric pill of sphere or class, coating or polishing, drying, concentrated pill.
Or with above-mentioned cream or cream powder and fine powder mixing; Add appropriate amount of auxiliary materials, mixing is made granule.
Or with above-mentioned cream or cream powder and fine powder mixing; Add appropriate amount of auxiliary materials, mixing, the system granule, tabletting, (coating, drying) in case of necessity makes tablet, dispersible tablet, buccal tablet.
Or, be sealed in the soft capsule material and make soft capsule above-mentioned ointment and fine powder and an amount of plant wet goods additives mixing.
The Jinsangliyan novel formulation that this preparation method is made (Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule) secundum legem detects, with control of quality, mainly comprise: the detection that quality inspection standard is checked by the rules of preparations requirement, the result is up to specification; The chromatograph of Neosynephrine, magnolol, honokiol, Semen Arecae, Hesperidin, naringin differentiates and detects that the result is up to specification; Heavy metal must not cross 10/1000000ths, arsenic salt must not be crossed 2/1000000ths limit detection, and the result is up to specification; Assay: contain Cortex Magnoliae Officinalis with magnolol (C
18H
18O
2) and honokiol (C
18H
18O
2) the total amount meter, each intake should 〉=5.3mg, the result is up to specification.
Embodiment two
Prepare the Jinsangliyan novel formulation according to the following steps, comprise Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule:
Get Poria 100g, Rhizoma Pinelliae Preparatum 100g, Fructus Aurantii Immaturus (stir-fry) 200g, Pericarpium Citri Reticulatae Viride (stir-fry) 210g, Arisaema Cum Bile 120g, tangerine 180g, Fructus Amomi 205g, Fructus Amomi Rotundus 45g, Semen Arecae 190g, Cortex Albiziae 146g, Massa Medicata Fermentata (stir-fry) 195g, Caulis Perillae 180g, Rhizoma Zingiberis Recens 35g, Periostracum Cicadae 120g, Semen Oroxyli 175g, Cortex Magnoliae Officinalis (system) 210g, standby;
A, above medicine is decocted with water secondary, each 1～3 hour, collecting decoction filtered, filtrate, standby;
B, medicinal liquid is concentrated into the thick paste that relative density is 1.20～1.40 (60 ℃); Or filtrate is concentrated into the extractum that relative density is 1.05～1.20 (60 ℃); Or after filtrate was concentrated into the extractum that relative density is 1.05～1.20 (60 ℃), spray drying got the cream powder;
Then, except that not adding the fine powder, surplus processes by embodiment one gets Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule.
Embodiment three:
Prepare the Jinsangliyan novel formulation according to the following steps, comprise Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule:
Get Poria 165g, Rhizoma Pinelliae Preparatum 165g, Fructus Aurantii Immaturus (stir-fry) 165g, Pericarpium Citri Reticulatae Viride (stir-fry) 165g, Arisaema Cum Bile 165g, tangerine 165g, Fructus Amomi 165g, Fructus Amomi Rotundus 82.5g, Semen Arecae 165g, Cortex Albiziae 165g, Massa Medicata Fermentata (stir-fry) 165g, Caulis Perillae 165g, Rhizoma Zingiberis Recens 24.8g, Periostracum Cicadae 165g, Semen Oroxyli 165g, Cortex Magnoliae Officinalis (system) 165g, standby;
In A, the above medicine, get Arisaema Cum Bile, amomum powder is broken into fine powder, sieve, mixing, standby;
B, get Fructus Aurantii Immaturus (stir-fry), Pericarpium Citri Reticulatae Viride (stir-fry), the tangerine volatile oil that extracts, collect volatile oil, device is preserved in addition, and is standby;
C, with all the other ten medical materials simply, decoct with water secondary, filter, merging filtrate is concentrated into the thick paste shape, and is standby;
D, above-mentioned thick paste is put cold. add ethanol, make to contain the alcohol amount and reach 50～85%, leave standstill, get supernatant, reclaim ethanol, medicinal liquid is standby;
E, medicinal liquid is concentrated into relative density is 1.03～1.05 clear paste; Or medicinal liquid is concentrated into the thick paste that relative density is 1.28～1.32 (85 ℃); Or medicinal liquid is concentrated into the extractum that relative density is 1.03～1.20 (85 ℃), be dried to powder;
Then, the processes by embodiment one gets Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule.
Embodiment 4:
Prepare the Jinsangliyan novel formulation according to the following steps, comprise Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule:
Get Poria 175g, Rhizoma Pinelliae Preparatum 185g, Fructus Aurantii Immaturus (stir-fry) 168g, Pericarpium Citri Reticulatae Viride (stir-fry) 190g, Arisaema Cum Bile 185g, tangerine 195g, Fructus Amomi 175g, Fructus Amomi Rotundus 82.5g, Semen Arecae 175g, Cortex Albiziae 185g, Massa Medicata Fermentata (stir-fry) 190g, Caulis Perillae 175g, Rhizoma Zingiberis Recens 24.8g, Periostracum Cicadae 190g, Semen Oroxyli 175g, Cortex Magnoliae Officinalis (system) 180g, standby;
In A, the above medicine, get Arisaema Cum Bile 100g, Fructus Amomi 95g is ground into fine powder, sieve, mixing, standby;
B, Fructus Aurantii Immaturus (stir-fry) 90g, Pericarpium Citri Reticulatae Viride (stir-fry) 110g, tangerine 105g extract volatile oil, collect volatile oil, and device is preserved in addition, and is standby;
C, with all the other ten medical materials simply, decoct with water secondary, filter, merging filtrate is concentrated into the thick paste shape, and is standby;
D, above-mentioned thick paste is put cold, added ethanol, make to contain the alcohol amount and reach 50～85%, leave standstill, get supernatant, reclaim ethanol, medicinal liquid is standby;
E, medicinal liquid is concentrated into relative density is 1.03～1.05 clear paste; Or medicinal liquid is concentrated into the thick paste that relative density is 1.28～1.32 (85 ℃); Or medicinal liquid is concentrated into the extractum that relative density is 1.03～1.20 (85 ℃), be dried to powder;
Then, the processes by embodiment one gets Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule.
Embodiment five:
Prepare the Jinsangliyan novel formulation according to the following steps, comprise Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule:
Get Poria 145g, Rhizoma Pinelliae Preparatum 185g, Fructus Aurantii Immaturus (stir-fry) 175g, Pericarpium Citri Reticulatae Viride (stir-fry) 155g, Arisaema Cum Bile 145g, tangerine 185g, Fructus Amomi 175g, Fructus Amomi Rotundus 90g, Semen Arecae 155g, Cortex Albiziae 185g, Massa Medicata Fermentata (stir-fry) 175g, Caulis Perillae 145g, Rhizoma Zingiberis Recens 28g, Periostracum Cicadae 155g, Semen Oroxyli 175g, Cortex Magnoliae Officinalis (system) 145g, standby;
In A, the above medicine, get Arisaema Cum Bile 130g, Fructus Amomi 155g, Poria 70g is ground into fine powder, sieve, mixing, standby;
B, Fructus Aurantii Immaturus (stir-fry) 155g, Pericarpium Citri Reticulatae Viride (stir-fry) 135g, tangerine 165g extract volatile oil, collect volatile oil, and device is preserved in addition, and is standby;
C, with all the other ten medical materials simply, decoct with water secondary, filter, merging filtrate is concentrated into the thick paste shape, and is standby;
D, above-mentioned thick paste is put cold, added ethanol, make to contain the alcohol amount and reach 50～85%, leave standstill, get supernatant, reclaim ethanol, medicinal liquid is standby;
E, medicinal liquid is concentrated into relative density is 1.03～1.05 clear paste; Or medicinal liquid is concentrated into the thick paste that relative density is 1.28～1.32 (85 ℃); Or medicinal liquid is concentrated into the extractum that relative density is 1.03～1.20 (85 ℃), be dried to powder;
Then, the processes by embodiment one gets Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule.
Embodiment six:
Prepare the Jinsangliyan novel formulation according to the following steps, comprise Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule:
Get Poria 155g, Rhizoma Pinelliae Preparatum 180g, Fructus Aurantii Immaturus (stir-fry) 140g, Pericarpium Citri Reticulatae Viride (stir-fry) 130g, Arisaema Cum Bile 170g, tangerine 140g, Fructus Amomi 180g, Fructus Amomi Rotundus 85g, Semen Arecae 155g, Cortex Albiziae 145g, Massa Medicata Fermentata (stir-fry) 135g, Caulis Perillae 155g, Rhizoma Zingiberis Recens 22g, Periostracum Cicadae 180g, Semen Oroxyli 175g, Cortex Magnoliae Officinalis (system) 155g, standby;
In A, the above medicine, get Arisaema Cum Bile 80g, Fructus Amomi 90g, Poria 50g is ground into fine powder, sieve, mixing, standby;
B, Fructus Aurantii Immaturus (stir-fry) 70g, Pericarpium Citri Reticulatae Viride (stir-fry) 65g, tangerine 70g extract volatile oil, collect volatile oil, and device is preserved in addition, and is standby;
C, with all the other ten medical materials simply, decoct with water secondary, filter, merging filtrate is concentrated into the thick paste shape, and is standby;
D, above-mentioned thick paste is put cold, added ethanol, make to contain the alcohol amount and reach 50～85%, leave standstill, get supernatant, reclaim ethanol, medicinal liquid is standby;
E, medicinal liquid is concentrated into relative density is 1.03～1.05 clear paste; Or medicinal liquid is concentrated into the thick paste that relative density is 1.28～1.32 (85 ℃); Or medicinal liquid is concentrated into the extractum that relative density is 1.03～1.20 (85 ℃), be dried to powder;
Then, the processes by embodiment one gets Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule.
The described medicinal liquid of the foregoing description concentrates preferable employing concentrating under reduced pressure; Soak the dry best vacuum drying/spray drying that is of (thick) cream, the vacuum drying temperature is controlled at 50～80 ℃, and the best is 60 ℃; The spray drying inlet temperature is 100～200 ℃, and leaving air temp is 50～150 ℃, and best inlet temperature is 150～180 ℃, and leaving air temp is 80～100 ℃, all can significantly reduce loss of active ingredients.Preparation concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule, the ball of making/grain baking temperature: less than 80 ℃.The optimum drying temperature is 50～70 ℃.
The described fine particle size of the foregoing description is 80～160 purpose fine powders or 200～300 purpose superfine powder.
As extracting volatile ingredient (as volatile oil) is arranged in the foregoing description, its interpolation requirement is:
The preparation concentrated pill is as adding volatile oil, its adding method:
A, volatile oil add in the just dry unpolished hair ball, polishing, drying.
B, volatile oil add in the polishing fluid, with this polishing fluid first exsiccant hair ball are polished drying.
C, volatile oil is added among the ball mother drying after with cyclodextrin inclusion compound.
After d, the pill polishing, add volatile oil, mixing, airtight 24 hours.
Concentrated pill volatile oil adding method the best is: after pill, the polishing, add volatile oil, be heated to 30～40 ℃, in hermetic container airtight vexed 24 hours.
Preparation granule, tablet, dispersible tablet, buccal tablet then after making granule, add volatile oil as adding volatile oil, in hermetic container airtight vexed 24 hours.
The preparation soft capsule then adopts the method with volatile oil and ointment and an amount of plant wet goods additives mixing to add as adding volatile oil.
In the foregoing description, except that embodiment two, other embodiment has adopted several different methods to extract, and its better effects if is as shown in table 1.
Subordinate list 1,2 is that the preparation method of product of the present invention and existing dosage form and the performance of products obtained therefrom compare, and therefrom the performance of visible preparation method products obtained therefrom of the present invention is better than prior art greatly.
Subordinate list 1 is existing dosage form (water-honeyed pill, big honeyed pills) and preparation method thereof, method of quality control, properties of product etc.
Subordinate list 2 is product novel formulation of the present invention, comprises Jinsangliyan concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule and preparation method thereof, method of quality control, properties of product etc.
Table 1
Subordinate list 2
Claims (6)
1, a kind of 'Jinsang Liyan ', it is characterized in that preparation formulation is concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule, described preparation is made up of following raw materials by weight percent: Poria, Rhizoma Pinelliae Preparatum, Fructus Aurantii Immaturus (stir-fry), Pericarpium Citri Reticulatae Viride (stir-fry), Arisaema Cum Bile, dried tangerine peel, Fructus Amomi, Semen Arecae, Cortex Albiziae, Massa Medicata Fermentata (stir-fry), Caulis Perillae, Periostracum Cicadae, Semen Oroxyli, Cortex Magnoliae Officinalis (system) each 3～10%, Fructus Amomi Rotundus 1～6%, Rhizoma Zingiberis Recens 0.2～2%.
2, according to the described 'Jinsang Liyan ' of claim 1, it is characterized in that the preferable percentage by weight of described raw material be Poria, Rhizoma Pinelliae Preparatum, Fructus Aurantii Immaturus (stir-fry), Pericarpium Citri Reticulatae Viride (stir-fry), Arisaema Cum Bile, dried tangerine peel, Fructus Amomi, Semen Arecae, Cortex Albiziae, Massa Medicata Fermentata (stir-fry), Caulis Perillae, Periostracum Cicadae, Semen Oroxyli, Cortex Magnoliae Officinalis (system) each 6.83%, Fructus Amomi Rotundus 3.41%, Rhizoma Zingiberis Recens 1.03%.
3, according to the preparation method of claim 1 or 2 described 'Jinsang Liyan 's, it is characterized in that this preparation method be according to described raw medicinal material character characteristics separately will be wherein the extract of part material medical material with wherein the protogenic medicinal powder and the additive of part material medical material are mixed and made into above-mentioned required dosage form, the extract of described medical material is meant the effective ingredient that adopts one or more extracting method to extract with a kind of raw material, described additive is adjuvant, excipient, additives, and extracting method comprises that water is carried or other solvent extraction.
4, according to the preparation method of the described 'Jinsang Liyan ' of claim 3, it is characterized in that described extract accounts for 60～100% of described medicine constituent gross weight, the granular size of described protogenic medicinal powder is 80～160 purpose fine powders or 200～300 purpose superfine powder.
5, according to the preparation method of the described 'Jinsang Liyan ' of claim 3, it is characterized in that described water is carried or other solvent extraction is that decocting extracts or ethanol extraction, the extracting solution that is obtained be condensed into relative density be 1.03～1.05 clear paste or be condensed into relative density be 1.05～1.40 soak (thick) cream, (thick) cream be will soak by dry fine powder or the superfine powder of getting, and then routine techniques and the molding of additive hybrid process adopted.
6, according to the preparation method of the described 'Jinsang Liyan ' of claim 3, it is characterized in that described preparation method is to get Arisaema Cum Bile, each 50-100% of Fructus Amomi, Poria 0-50%, be ground into fine powder, sieve, mixing, standby; Fructus Aurantii Immaturus (stir-fry), Pericarpium Citri Reticulatae Viride (stir-fry), tangerine each 50-100% extract volatile oil, collect volatile oil, preserve, and be standby; With all the other ten medical materials simply, decoct with water secondary, filter, merging filtrate is concentrated into the thick paste shape, and is standby; Above-mentioned thick paste is put cold, added ethanol, make to contain the alcohol amount and reach 50～85%, leave standstill, get supernatant, reclaim ethanol, medicinal liquid is standby; Then above fine powder, volatile oil, medicinal liquid are processed into concentrated pill, granule, tablet, dispersible tablet, buccal tablet, soft capsule.
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| CNA2006100091684A CN101024066A (en) | 2006-02-19 | 2006-02-19 | Jinsangliyan preparation and preparing method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102343082A (en) * | 2011-10-26 | 2012-02-08 | 西安碑林药业股份有限公司 | Chinese medicinal composition for dispersing the depressed liver-energy, reducing phlegm and relieving sore throat and preparation method thereof |
| CN102363036A (en) * | 2011-10-26 | 2012-02-29 | 西安碑林药业股份有限公司 | Chinese medicinal composition for clearing throat and pharynx, and preparation method thereof |
| CN103251831A (en) * | 2013-05-09 | 2013-08-21 | 李建华 | Medicament for treating pharyngeal paraesthesia and preparation method thereof |
| CN112972402A (en) * | 2021-03-26 | 2021-06-18 | 宋宏春 | Oil-containing Mongolian medicine powder formula granule and preparation method thereof |
| CN113318085A (en) * | 2021-06-07 | 2021-08-31 | 云南中医药大学 | Fructus amomi tablet for improving vomiting of pregnancy reaction and preparation method thereof |
-
2006
- 2006-02-19 CN CNA2006100091684A patent/CN101024066A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102343082A (en) * | 2011-10-26 | 2012-02-08 | 西安碑林药业股份有限公司 | Chinese medicinal composition for dispersing the depressed liver-energy, reducing phlegm and relieving sore throat and preparation method thereof |
| CN102363036A (en) * | 2011-10-26 | 2012-02-29 | 西安碑林药业股份有限公司 | Chinese medicinal composition for clearing throat and pharynx, and preparation method thereof |
| CN103251831A (en) * | 2013-05-09 | 2013-08-21 | 李建华 | Medicament for treating pharyngeal paraesthesia and preparation method thereof |
| CN112972402A (en) * | 2021-03-26 | 2021-06-18 | 宋宏春 | Oil-containing Mongolian medicine powder formula granule and preparation method thereof |
| CN112972402B (en) * | 2021-03-26 | 2022-09-20 | 那生桑 | Oil-containing Mongolian medicine powder formula granule and preparation method thereof |
| CN113318085A (en) * | 2021-06-07 | 2021-08-31 | 云南中医药大学 | Fructus amomi tablet for improving vomiting of pregnancy reaction and preparation method thereof |
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