CN101015542A - Compound paracetamol injection for livestock and process for preparing same - Google Patents
Compound paracetamol injection for livestock and process for preparing same Download PDFInfo
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- CN101015542A CN101015542A CNA200710056801XA CN200710056801A CN101015542A CN 101015542 A CN101015542 A CN 101015542A CN A200710056801X A CNA200710056801X A CN A200710056801XA CN 200710056801 A CN200710056801 A CN 200710056801A CN 101015542 A CN101015542 A CN 101015542A
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Abstract
The invention discloses a compound acetaminophen injection for livestock and its preparation method. the injection comprises acetaminophen 50-200, diclofenac sodium 10-50, polyethylene glycol-400 100-500, propylene glycol 100-500, and sodium bisulfite 10-30. the preparation method comprises (1) mixing polyethylene glycol-400 and propylene glycol, heating to 70-80deg.C, adding diclofenac sodium, stirring, adding acetaminophen, stirring; (2) heating water for injection to 30-40deg.C, adding sodium bisulfite, stirring; and (3) merging the solutions of steps 1 and 2, adjusting pH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, and adding water for injection to 1000 to obtain the final product. The invention strengthen antipyretic and analgesic effects, is effective for treating pain and fever due to different kinds of inflammation, and can improve animal survival rate and increase animal body weight.
Description
Technical field
The present invention relates to the medicaments injection field, particularly relate to a kind of domestic animal and use Aminodyne Compound injection and preparation method thereof.
Background technology
The high-heat livestock disease is one of modal disease, is seriously restricting the development of aquaculture.Various places make pathogenic microorganism produce Drug resistance to medicine, and have reduced curative effect owing to the single antipyretic-antalgic anti-inflammatory agent of prolonged and repeated use in decades.
Summary of the invention
The objective of the invention is provides a kind of avoiding to use a kind of antipyretic-antalgic anti-inflammatory agent repeatedly in order to enlarge the antipyretic-antalgic scope and the effect of medicine, and makes domestic animal that pathogenic microorganism etc. develops immunity to drugs with Aminodyne Compound injection and preparation method thereof.
Aminodyne Compound injection of the present invention, be by following component by described content proportioning: acetaminophen 50-200 part, diclofenac sodium 10-50 part, Polyethylene Glycol-400 (PEG-400) 100-500 part, propylene glycol 100-500 part, sodium sulfite 10-30 part.
The preferred proportioning of the present invention: 100 parts of acetaminophen, 15 parts of diclofenac sodiums, Polyethylene Glycol-400 (PEG-400) 100-500 part, propylene glycol 100-500 part, sodium sulfite 10-30 part.
The most preferred proportioning of the present invention: 20 parts of 100 parts of acetaminophen, 15 parts of diclofenac sodiums, 300 parts of propylene glycol, Polyethylene Glycol-400 300 part, sodium sulfitees.
A kind of preparation method of Aminodyne Compound injection, form by following steps:
(1) takes by weighing acetaminophen 50-200 part, diclofenac sodium 10-50 part, Polyethylene Glycol-400 (PEG-400) 100-500 part, propylene glycol 100-500 part, sodium sulfite 10-30 part by weight;
(2) with described Polyethylene Glycol-400 and mixed with propylene glycol post-heating to 70-80 ℃, add described diclofenac sodium and be stirred to clear and bright; Adding described acetaminophen again is stirred to clear and bright;
(3) get 200-300 part water for injection in addition and be heated to 30-40 ℃, add described sodium sulfite and be stirred to clear and bright;
(4) solution that makes of combining step (2) and step (3) is regulated PH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, adds injection water to 1000 and part promptly makes a kind of Aminodyne Compound injection.
With the heating due to preparation treatment flu and fever of livestock, arthralgia, myalgia, neuralgia, all kinds of joints rhematic inflammation and a variety of causes of a kind of Aminodyne Compound injection of method for preparing.
Advantage of the present invention is: adopt compound preparation, experimental results show that, acetaminophen and diclofenac sodium unite use, existing active remedy has lasting medicine and both to be used again and is not having the drug accumulation phenomenon according to recommended dose and scheme repeat administration, clinical practice is extensive, can be widely used in heating and pain due to a variety of causes, improve the survival rate of domestic animal, increase the body weight of domestic animal.
Acetaminophen is synthetic by suppressing among the central nervous system prostaglandin, and the impulsion of blocking-up pain nerve tip and playing a role, and acting on the hypothalamus thermotaxic centre, to play that antipyretic effect is analgesic, analgesic activity relaxes lasting.Diclofenac sodium absorbs rapidly, the concentration predose is linear, remedied the demulcent deficiency of acetaminophen effect, existing active remedy has lasting medicine and both to be used not having the drug accumulation phenomenon according to recommended dose and scheme repeat administration again, meets the Therapeutic Principle of clinical disease.Be applicable to the heating due to flu and fever of livestock, arthralgia, myalgia, neuralgia, all kinds of joints rhematic inflammation and a variety of causes.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1 (every part is 500g)
Aminodyne Compound injection: 110 parts of acetaminophen, 20 parts of diclofenac sodiums, 300 parts of Polyethylene Glycol-400 (PEG-400), 300 parts of propylene glycol, 20 parts of sodium sulfitees.
Make with following method:
(1) takes by weighing 110 parts of acetaminophen, 20 parts of diclofenac sodiums, 300 parts of Polyethylene Glycol-400 (PEG-400), 300 parts of propylene glycol, 20 parts of sodium sulfitees by weight;
(2) with described Polyethylene Glycol-400 and mixed with propylene glycol post-heating to 70-80 ℃, add described diclofenac sodium and be stirred to clear and bright; Adding described acetaminophen again is stirred to clear and bright;
(3) get 200 parts of waters for injection in addition and be heated to 30-40 ℃; Adding described sodium sulfite is stirred to clear and bright;
(4) solution that makes of combining step (2) and step (3) is regulated PH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, adds injection water to 1000 and part promptly makes a kind of Aminodyne Compound injection.
Embodiment 2 (every part is 1500g)
The Aminodyne Compound injection, 50 parts of acetaminophen, 10 parts of diclofenac sodiums, 100 parts of Polyethylene Glycol-400 (PEG-400), 100 parts of propylene glycol, 10 parts of sodium sulfitees.
Make with following method:
(1) takes by weighing 50 parts of acetaminophen, 10 parts of diclofenac sodiums, 100 parts of Polyethylene Glycol-400 (PEG-400), 100 parts of propylene glycol, 10 parts of sodium sulfitees by weight;
(2) with described Polyethylene Glycol-400 and mixed with propylene glycol post-heating to 70-80 ℃, add described diclofenac sodium and be stirred to clear and bright; Adding described acetaminophen again is stirred to clear and bright;
(3) get 200 parts of waters for injection in addition and be heated to 30-40 ℃; Adding described sodium sulfite is stirred to clear and bright;
(4) solution that makes of combining step (2) and step (3) is regulated PH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, adds injection water to 1000 and part promptly makes a kind of Aminodyne Compound injection.
Embodiment 3 (every part is 2500g)
The Aminodyne Compound injection, 120 parts of acetaminophen, 20 parts of diclofenac sodiums, 350 parts of Polyethylene Glycol-400 (PEG-400), 350 parts of propylene glycol, 30 parts of sodium sulfitees.
Make with following method:
(1) takes by weighing 120 parts of acetaminophen, 20 parts of diclofenac sodiums, 350 parts of Polyethylene Glycol-400 (PEG-400), 350 parts of propylene glycol, 30 parts of sodium sulfitees by weight;
(2) with described Polyethylene Glycol-400 and mixed with propylene glycol post-heating to 70-80 ℃, add described diclofenac sodium and be stirred to clear and bright; Adding described acetaminophen again is stirred to clear and bright;
(3) get 200 parts of waters for injection in addition and be heated to 30-40 ℃; Adding described sodium sulfite is stirred to clear and bright;
(4) solution that makes of combining step (2) and step (3) is regulated PH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, adds injection water to 1000 and part promptly makes a kind of Aminodyne Compound injection.
Embodiment 4 (every part is 1500g)
Aminodyne Compound injection: 200 parts of acetaminophen, 50 parts of diclofenac sodiums, 500 parts of Polyethylene Glycol-400 (PEG-400), 500 parts of propylene glycol, 20 parts of sodium sulfitees.
Make with following method:
(1) takes by weighing 200 parts of acetaminophen, 50 parts of diclofenac sodiums, 500 parts of Polyethylene Glycol-400 (PEG-400), 500 parts of propylene glycol, 20 parts of sodium sulfitees by weight;
(2) with described Polyethylene Glycol-400 and mixed with propylene glycol post-heating to 70-80 ℃, add described diclofenac sodium and be stirred to clear and bright; Adding described acetaminophen again is stirred to clear and bright;
(3) get 200 parts of waters for injection in addition and be heated to 30-40 ℃; Adding described sodium sulfite is stirred to clear and bright;
(4) solution that makes of combining step (2) and step (3) is regulated PH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, adds injection water to 1000 and part promptly makes a kind of Aminodyne Compound injection.
Clinical trial:
Picked at random virus-free infection and stress situation, but 100 of the piglets of heating paresthesia are arranged, and according to body condition, term, close situation was divided into four groups.
| Numbering | Group | Mortality rate % | Inefficiency % | Effective percentage % | Cure rate % | The symptom pig's head is arranged during end | The relative weight gain |
| A | Do not treat (matched group) | 2 | - | - | - | - | - |
| B | The acetaminophen treatment | 1 | 5.3 | 73.3 | 68.3 | 5 | 69.2 |
| C | The diclofenac sodium treatment | 1 | 3.6 | 72.4 | 73.4 | 3 | 72.5 |
| D | Aminodyne Compound | 0 | 1.2 | 98.3 | 88.8 | 1 | 80.0 |
This result of the test is analyzed by statistics, and Aminodyne Compound injection for treating group, diclofenac sodium treatment group and matched group difference is (P＜0.01) extremely significantly, acetaminophen treatment group and matched group significant difference (P＜0.05).
Claims (4)
1. a domestic animal is used the Aminodyne Compound injection, it is characterized in that, press described content proportioning by following component: acetaminophen 50-200 part, diclofenac sodium 10-50 part, Polyethylene Glycol-400 (PEG-400) 100-500 part, propylene glycol 100-500 part, sodium sulfite 10-30 part.
2. domestic animal according to claim 1 is used the Aminodyne Compound injection, it is characterized in that 100 parts of acetaminophen, 15 parts of diclofenac sodiums, Polyethylene Glycol-400 (PEG-400) 100-500 part, propylene glycol 100-500 part, sodium sulfite 10-30 part.
3. domestic animal according to claim 1 is used the Aminodyne Compound injection, it is characterized in that 20 parts of 100 parts of acetaminophen, 15 parts of diclofenac sodiums, 300 parts of propylene glycol, Polyethylene Glycol-400 300 part, sodium sulfitees.
4. a domestic animal is used the Aminodyne Compound injection preparation, it is characterized in that, is made up of following step:
(1) takes by weighing acetaminophen 50-200 part, diclofenac sodium 10-50 part, Polyethylene Glycol-400:100-500 part, propylene glycol 100-500 part, sodium sulfite 10-30 part by weight;
(2) with described Polyethylene Glycol-400 and mixed with propylene glycol post-heating to 70-80 ℃, add described diclofenac sodium and be stirred to clear and bright; Adding described acetaminophen again is stirred to clear and bright;
(3) get 200-300 part water for injection in addition and be heated to 30-40 ℃; Adding described sodium sulfite is stirred to clear and bright;
(4) solution that makes of combining step (2) and step (3) is regulated PH to 4.5-6.5 with hydrochloric acid or sodium hydroxide, adds injection water to 1000 and part promptly makes a kind of domestic animal and use the Aminodyne Compound injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710056801XA CN101015542A (en) | 2007-02-13 | 2007-02-13 | Compound paracetamol injection for livestock and process for preparing same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200710056801XA CN101015542A (en) | 2007-02-13 | 2007-02-13 | Compound paracetamol injection for livestock and process for preparing same |
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| Publication Number | Publication Date |
|---|---|
| CN101015542A true CN101015542A (en) | 2007-08-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNA200710056801XA Pending CN101015542A (en) | 2007-02-13 | 2007-02-13 | Compound paracetamol injection for livestock and process for preparing same |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102421426A (en) * | 2009-04-22 | 2012-04-18 | 弗雷泽纽斯卡比德国有限公司 | Paracetamol for parenteral administration |
| CN102755342A (en) * | 2012-07-31 | 2012-10-31 | 山东中牧兽药有限公司 | Compound paracetamol injection and preparation method thereof |
| CN101816643B (en) * | 2009-12-31 | 2013-02-13 | 王石齐 | Medicament composition containing diclofenac sodium and acetaminophen |
| CN103463192A (en) * | 2013-08-27 | 2013-12-25 | 江西新世纪民星动物保健品有限公司 | Compound acetaminophen injection and preparation method thereof |
| CN104586758A (en) * | 2015-01-20 | 2015-05-06 | 石家庄四药有限公司 | Paracetamol injection and preparation method thereof |
| CN105982853A (en) * | 2015-03-17 | 2016-10-05 | 成都医学院 | Paracetamol infusion solution and preparation method and application thereof |
| MD4537B1 (en) * | 2012-06-29 | 2017-12-31 | Sintetica S.A. | Injectable supersaturated acetaminophen solution for spinal administration |
-
2007
- 2007-02-13 CN CNA200710056801XA patent/CN101015542A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102421426A (en) * | 2009-04-22 | 2012-04-18 | 弗雷泽纽斯卡比德国有限公司 | Paracetamol for parenteral administration |
| CN101816643B (en) * | 2009-12-31 | 2013-02-13 | 王石齐 | Medicament composition containing diclofenac sodium and acetaminophen |
| MD4537B1 (en) * | 2012-06-29 | 2017-12-31 | Sintetica S.A. | Injectable supersaturated acetaminophen solution for spinal administration |
| CN102755342A (en) * | 2012-07-31 | 2012-10-31 | 山东中牧兽药有限公司 | Compound paracetamol injection and preparation method thereof |
| CN103463192A (en) * | 2013-08-27 | 2013-12-25 | 江西新世纪民星动物保健品有限公司 | Compound acetaminophen injection and preparation method thereof |
| CN103463192B (en) * | 2013-08-27 | 2015-10-28 | 江西新世纪民星动物保健品有限公司 | Compound Paracetamol Injection Determined and preparation method thereof |
| CN104586758A (en) * | 2015-01-20 | 2015-05-06 | 石家庄四药有限公司 | Paracetamol injection and preparation method thereof |
| CN104586758B (en) * | 2015-01-20 | 2017-09-22 | 石家庄四药有限公司 | A kind of paracetamol injection determined and preparation method thereof |
| CN105982853A (en) * | 2015-03-17 | 2016-10-05 | 成都医学院 | Paracetamol infusion solution and preparation method and application thereof |
| CN105982853B (en) * | 2015-03-17 | 2019-03-29 | 成都医学院 | Big infusion of a kind of paracetamol and its preparation method and application |
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Open date: 20070815 |