CN101007137A - 'Qimailing' oral liquid and its preparation method - Google Patents
'Qimailing' oral liquid and its preparation method Download PDFInfo
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Abstract
The invention discloses an oral liquid and its preparing process, wherein the formula comprises (by weight ratio) astragalus root 130-170 part, white atractylodes rhizome 130-170 parts, root of Chinese trichosannthes 280-320 parts, rehmannia root 280-320 parts, Chinese yam 280-320 parts, pilose asiabell root 80-120 parts, ophiopogon root 80-120 parts, wind-weed rhizome 180-220 parts, bark of peony root 180-220 parts, root of red rooted saliva 280-320 parts and poria cocos wolf 80-120 parts.
Description
Technical field
The invention belongs to the field of Chinese medicines, be a kind of 'Qimailing ' oral liquid and preparation method thereof.
Background technology
At present, diabetes are commonly encountered diseases, prevalence rapidly increases, more to the research of treatment of diabetes aspect both at home and abroad, oral antidiabetic drug is developed antidiabetic drug of new generation such as α glycosidase inhibitor, insulin succagoga, euglycemic agent etc. fast again except that original sulphanylureas, biguanides.Oral antidiabetic drug has many unsatisfactory parts, sulphanylureas easily causes hypoglycemia, biguanides easily causes digestive tract reaction, lactic acidosis, and some drugs costs an arm and a leg, though the insulin clinical practice has the history of decades, but because treatment condition, route of administration and to aspects factors such as insulin understanding deficiencies still can not be accepted by the part patient.And the gene therapy that is expected to effect a radical cure diabetes is not most succeeded in developing as yet.At tcm field, though that prescription has is many, hypoglycemic effect, to the influence of islet function and prevent and treat aspect such as complication uncertainly.Therefore, at present domestic press for can be steadily effective blood sugar control, few side effects can improve islet function again, can also stop complication that the medicine of development takes place.
Summary of the invention
Purpose of the present invention is exactly the problem for the Chinese medicine poor effect that solves present treatment diabetes, a kind of beta Cell of islet of improvement function that has is provided, improves the sensitivity of insulin, steadily the purpose of blood sugar lowering, can reduce side effect again, stop the 'Qimailing ' oral liquid of advantages such as complication.
Another object of the present invention provides a kind of preparation method of 'Qimailing ' oral liquid, to give full play to its curative effect.
For achieving the above object, the present invention has adopted following technical scheme:
A kind of 'Qimailing ' oral liquid, its constituent by weight, Radix Astragali 130-170 part, Rhizoma Atractylodis Macrocephalae 130-170 part, Radix Trichosanthis 280-320 part, Radix Rehmanniae 280-320 part, Rhizoma Dioscoreae 280-320 part, Radix Codonopsis 80-120 part, Radix Ophiopogonis 80-120 part, Rhizoma Anemarrhenae 180-220 part, Cortex Moutan 180-220 part, Radix Salviae Miltiorrhizae 280-320 part, Poria 80-120 part.
Its constituent by weight, 130 parts of the Radixs Astragali, 130 parts of the Rhizoma Atractylodis Macrocephalaes, 280 parts of Radix Trichosanthis, 280 parts of Radix Rehmanniae, 280 parts of Rhizoma Dioscoreaes, 80 parts of Radix Codonopsis, 80 parts of Radix Ophiopogonis, 180 parts of the Rhizoma Anemarrhenaes, 180 parts of Cortex Moutans, 280 parts of Radix Salviae Miltiorrhizaes, 80 parts in Poria.
Its constituent by weight, 150 parts of the Radixs Astragali, 150 parts of the Rhizoma Atractylodis Macrocephalaes, 300 parts of Radix Trichosanthis, 300 parts of Radix Rehmanniae, 300 parts of Rhizoma Dioscoreaes, 100 parts of Radix Codonopsis, 100 parts of Radix Ophiopogonis, 200 parts of the Rhizoma Anemarrhenaes, 200 parts of Cortex Moutans, 300 parts of Radix Salviae Miltiorrhizaes, 100 parts in Poria.
Its constituent by weight, 170 parts of the Radixs Astragali, 170 parts of the Rhizoma Atractylodis Macrocephalaes, 320 parts of Radix Trichosanthis, 320 parts of Radix Rehmanniae, 320 parts of Rhizoma Dioscoreaes, 120 parts of Radix Codonopsis, 120 parts of Radix Ophiopogonis, 220 parts of the Rhizoma Anemarrhenaes, 220 parts of Cortex Moutans, 320 parts of Radix Salviae Miltiorrhizaes, 120 parts in Poria.
A kind of 'Qimailing ' oral liquid preparation method, its method is, with by weight Radix Astragali 130-170 part, Rhizoma Atractylodis Macrocephalae 130-170 part, Radix Trichosanthis 280-320 part, Radix Rehmanniae 280-320 part, Rhizoma Dioscoreae 280-320 part, Radix Codonopsis 80-120 part, Radix Ophiopogonis 80-120 part, Rhizoma Anemarrhenae 180-220 part, Cortex Moutan 180-220 part, Radix Salviae Miltiorrhizae 280-320 part, Poria 80-120 part, decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filtration concentrate filtrate, leave standstill, filter, add water to 1000 parts, stir evenly, fill, sterilization, promptly.
Before the described decoction, raw material is put into 8-10 times of water soaked at least 1 hour.
During described decoction, earlier raw material was decocted 2 hours down at 100 ℃, use filtered through gauze, filtrate is stand-by; Filtering residue decocted under 100 ℃ 1.5 hours again, used filtered through gauze then, and filtering residue discards, and two these filtrates are merged, and filtered once more.
Described when concentrated under 100 ℃, be concentrated into 800 parts and get final product.
During described sterilization, under 115 ℃, sterilized 0.5 hour.
The used component analysis of the present invention is as follows:
1, the Radix Astragali
Nature and flavor are sweet, tepor.Return spleen, lung meridian.Effect is a tonifying Qi and lifting yang, and benefit is defended consolidating superficial resistance, inducing diuresis to remove edema, holder skin ulcer granulation promoting.Be used for all cards of deficiency of spleen-QI and stomach-QI and sinking of QI of middle-JIAO; Insufficiency of lung-QI and exterior deficiency spontaneous perspiration, all cards of deficiency of vital energy diseases caused by exogenous pathogenic factor; Wet edema, the dysuria that loses fortune of deficiency of vital energy water; Insufficiency of vital energy and blood, skin infection cave in swells and does not burst or burst and do not hold back for a long time; To quenching one's thirst of deficiency of vital energy body fluid deficiency can tonifying QI to produce body fluid to quench the thirst etc.
Modern pharmacological research proves that the Radix Astragali contains glycoside, polysaccharide, aminoacid and trace element etc., has enhancing human body immunity function, diuresis, defying age, protects the liver, hypotensive effect.Can eliminate experimental nephritis urine protein, strengthen myocardial contraction, estrogenic promoting action and antibacterial action in addition more widely.Wherein the astramembrannin content, raise immunity, the promotion Liver Regeneration DNA that have blood pressure lowering, stablize erythrocyte membrane, improve a c-AMP in the blood plasma tissue such as synthesizes at multiple effect.Astragalus polysaccharides has the mice of raising stress ability, raise immunity, blood sugar regulation content, protection cardiovascular system, quickens to suffer the effects such as reparation of radiation damage body.
2, the Rhizoma Atractylodis Macrocephalae
The nature and flavor hardship, sweet, temperature.Return spleen, stomach warp.Effect is an air making-up and spleen enlivening, the dampness diuretic, and hidroschesis, antiabortive.Be used for deficiency of spleen-QI and stomach-QI, fortuneization is unable, anorexia and loose stool, distension and fullness in the abdomen, the soft Mental fatigue of limb; Insufficiency of the spleen water retention, and be phlegm retention, edema, dysuria; Deficiency of the spleen causing weakness of QI, and the not solid hyperhidrosis of flesh table; Deficiency of the spleen causing weakness of QI, frequent fetal movement.
The modern pharmacological research Rhizoma Atractylodis Macrocephalae contains volatile oil, and main component is an atractylone in the oil, atractylodes lactone A, B and saccharide (being mainly mannose, fructose) etc.That the Rhizoma Atractylodis Macrocephalae has is strong, diuresis, blood sugar lowering, anticoagulant effect, and can the liver protecting, prevents the effect that hepatic glycogen reduces due to the carbon tetrachloride.
3, Radix Trichosanthis
Nature and flavor are sweet, and little hardship is slightly cold.Attach to the lung and stomach meridians.Effect is a clearing away heat and promoting production of body fluid, clearing away lung-heat and moistening for dryness, removing toxicity for eliminating carbuncles.It is thirsty to be used for calentura, the polydipsia of quenching one's thirst; Be used for lung-heat type cough; The carbuncle skin infection.
Modern pharmacological research this product contains trichosanthin, Saponin, starch etc., and Hemolytic streptococcus, Diplococcus pneumoniae, diphtheria corynebacterium are had stronger inhibitory action.
4, Radix Rehmanniae
Nature and flavor are sweet, and hardship is cold.GUIXIN, liver, lung meridian.Effect is a clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.Be used for heat and go into nutrient blood, the xerostomia crimson tongue; Bleeding due to blood-heat, macule is told nosebleed; Tianjin wound is thirsty, and interior-heat is quenched one's thirst.
This product contains cupreol, rehmanin, mannitol, glucose, alkaloid, irony, vitamin A etc.The Radix Rehmanniae decoct has the liver protecting, prevents the effect that hepatic glycogen reduces.
5, Rhizoma Dioscoreae
Nature and flavor are sweet, and are flat.Return spleen, lung, kidney channel.Effect is a supplementing QI and nourishing YIN, and Gu spleen reinforcing lung kidney is through leukorrhagia stopping.Be used for weakness of the spleen and stomach; The lung weak card of suffering from a deficiency of the kidney; Interior-heat caused by deficiency of YIN, thirsty polydipsia, the diabete of frequent micturition.
Rhizoma Dioscoreae contains that dioscin, dioscin are former, choline, phytic acid, end power element, vitamin, mannan etc.Have nourishing, aid digestion, eliminating phlegm and stopping cough, desensitization and hypoglycemic activity etc.
6, Radix Codonopsis
Nature and flavor are sweet, and are flat.Return spleen, lung meridian.Effect is a QI invigorating, promotes the production of body fluid, and nourishes blood.The empty asthenia of body that is used for deficiency of QI in middle-JIAO, anorexia and loose stool etc.; Breathing hard that hinder in gas Tianjin two is thirsty, and the two face light yellow complexions that lose of QI and blood, dizzy cardiopalmus etc.
Radix Codonopsis contains Saponin, micro-alkaloid, saccharide, vitamin B
1, B
2, multiple needed by human inorganic elements and aminoacid etc.Radix Codonopsis has excitation to nervous system, energy enhancing body resistance; Tame rabbit erythrocyte and hemoglobin are increased; Can expand peripheral vessels and bring high blood pressure down, and can suppress adrenergic boosting; Have the adjusting gastrointestinal motility, antiulcer, the gastric acid inhibitory secretion reduces effects such as pepsin activity.
7, Radix Ophiopogonis
Nature and flavor are sweet, and little hardship is slightly cold.GUIXIN, lung, stomach warp.Effect is nourishing YIN and moistening the lung, reinforcing stomach reg fluid, relieving restlessness clears away heart-fire.Be used for lack of lung-YIN, scorching dry cough expectorant is sticking, the consumptive fever cough and have; Deficiency of stomach-YIN or thermal burn stomach-Yin, thirsty and dry pharynx, constipation due to dry stool; Deficiency of heart-yin and epidemic febrile disease pathogenic heat are disturbed and the heart-nutriment, dysphoria and insomnia, crimson tongue and do etc.
Contain Radix Ophiopogonis such as multiple dwarf lilyturf steroid saponin, cupreol, aminoacid, volume glucose and glycoside thereof etc.Can strengthen reticuloendothelial system phagocytic activity, the rising peripheral leukocytes improves immunologic function; Can strengthen the pituitary adrenal system effect, improve organism adaptation; Arrhythmia and the effect of expansion peripheral blood vessel are arranged; The blood sugar lowering effect is arranged.
8, the Rhizoma Anemarrhenae
The nature and flavor hardship, sweet, cold.Return lung, stomach, kidney channel.Effect is clearing away heat-fire, and is nourshing Yin and drynsessmoistening prescription.Be used for the calentura excessive thirst, deficiency of YIN cough caused by dryness; Osteopyrexia and fever; The deficiency of YIN is quenched one's thirst, the dryness of the intestine constipation.
Rhizoma Anemarrhenae rhizome contains multiple steroid saponin, and contains the phlegmatic temperament of volume.That zoopery proof has is significantly analgesic, eliminate the phlegm, diuresis, blood sugar lowering effect.
9, Cortex Moutan
The nature and flavor hardship, suffering is slightly cold.GUIXIN, liver, kidney channel.Effect is a clearing away heat and cooling blood, promoting blood circulation to remove blood stasis.Be used for the pathogenic warmth impairment of YIN, fever due to yin deficiency; Amenorrhea due to stagnation of blood, traumatic injury; The carbuncle and ulcer toxic swelling, abdominalgia with intestinal abscess.
This product contains paeonol, paeonolide, paeonolide, paeoniflorin, volatile oil and plant sterol etc.Paeonol and glucoside composition all have antiinflammatory action.Cortex Moutan alcohol has central inhibitory actions such as calmness, cooling, analgesic, analgesia, spasmolytic, and decocting liquid has obvious hypotensive effect.
10, Radix Salviae Miltiorrhizae
The nature and flavor hardship is slightly cold.GUIXIN, Liver Channel.Effect is a promoting blood flow to regulate menstruation, and the removing heat from blood eliminating carbuncle is calmed the nerves.Be used for menoxenia, dysmenorrhea, amenorrhea, the stasis of blood stagnated and suffered from abdominal pain puerperal; The ambition of blood stasis, epigastric pain, rheumatic arthralgia; The skin infection carbuncle; Fidgety stupor of calentura and miscellaneous diseases palpitation and insomnia etc.
This product contains fat-soluble non-quinones composition: Tanshinone I, II
A, II
B, cryptotanshinone, dihydrotanshinone etc.; Water soluble ingredient: protocatechualdehyde, protocatechuic acid, danshensu, vitamin E etc.Radix Salviae Miltiorrhizae can coronary artery dilator, increase coronary flow, improve myocardial ischemia, infraction and cardiac function, adjusts the rhythm of the heart, and can expand peripheral blood vessel, microcirculation improvement; Anticoagulant is arranged, promote fibrinolytic, anticoagulant suppresses thrombotic effect; The energy blood fat reducing suppresses the formation of coronary artery atheromatous plaque; Enhance immunity is arranged, blood sugar lowering and antitumor action.
11, Poria
Nature and flavor are sweet, and are light, flat.GUIXIN, spleen, kidney channel.Effect is a promoting diuresis to eliminate damp pathogen, spleen-benefiting mind-tranquilizing.Be used for various edema; Insufficiency of the spleen all cards; Palpitation and insomnia.
Poria contains pachyman, pachymic acid, protein, fat, lecithin, choline, histidine, ergosterol etc.Poria has the effect of diuresis, calmness and blood sugar lowering.
All medicines such as the Radix Astragali in the side, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae have QI invigorating to give birth to the effect of the moon, Lijin, Radix Rehmanniae, tonifying the spleen and stomach, taste lung kidney, the effect of heat clearing away, Yin-nourishing and body fluid promoting is arranged the Rhizoma Anemarrhenae, Radix Ophiopogonis, effects such as Cortex Moutan has heat clearing away, removing heat from blood, the pain that disappears, relieving restlessness are calmed the nerves, reach the treatment deficiency of both QI and YIN, promoting blood circulation to remove obstruction in the collateral, treatment type 2 diabetes mellitus and complication.
Character of the present invention is the liquid of rufous; The sweet little hardship of distinguishing the flavor of; Function cures mainly: be mainly used in the treatment deficiency of both QI and YIN, promoting blood circulation to remove obstruction in the collateral, type 2 diabetes mellitus and prevent and treat complication.
Because the diabetes spp traditional Chinese medical science category of " quenching one's thirst ", the traditional Chinese medical science thinks that pathogenic factor is an innate deficiency, and disorder of emotion, eating and drinking without temperance, work and rest are excessive, and treatment should the YIN nourishing spleen reinforcing, transfer liver, temperance for food and drink and having regular daily life.The traditional Chinese medical science is accumulating extremely abundant clinical experience aspect the treatment diabetes, and has modern medicine to be difficult to alternate unique distinction." taking stopgap measures " mainly emphasized in the modern medicine treatment, and mainly by stimulating insulin secretion, biguanides mainly is to reduce hepatic glycogen to decompose, increase to organize and utilize glucose to come blood sugar lowering to present oral sulphanylureas commonly used.And the traditional Chinese medical science is emphasized " effecting a permanent cure ", by supplementing QI and nourishing YIN, reaches the effect of conditioning blood glucose, and therapy of combining Chinese and Western medicine may be passed through " treating both the principal and secondary aspects of a disease " more effectively blood sugar control.
'Qimailing ' oral liquid of the present invention comes clearing heat and moistening dryness, YIN nourishing and the production of body fluid promoting, and benefiting QI for activating blood circulation, YIN nourishing is reinforced the kidney, enhance immunity.We reuse Radix Rehmanniae, Radix Ophiopogonis, pollen, and the Kidney-Yin kidney-Yang of nourishing kidney is gone into lung stomach kidney channel, YIN nourishing and the production of body fluid promoting, clearing heat and moistening dryness; The Radix Astragali, Rhizoma Dioscoreae benefiting QI for activating blood circulation, the spleen reinforcing yang invigorating is inspired gastric qi, on can promote the production of body fluid, kind controlling quenched one's thirst; With the spleen invigorating of Poria dampness removing; Cortex Moutan rushes down part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels FUSHUI, full side is mended and oiliness.Modern pharmacological research finds that the single medicinal material of QI invigorating such as the Radix Astragali, Radix Ophiopogonis, Rhizoma Dioscoreae, the Rhizoma Atractylodis Macrocephalae, Poria, spleen invigorating all has the effect of blood sugar lowering.Animal experiment confirms that also spleen invigorating blood sugar lowering class Chinese medicine can not only stimulate the secretory function of beta Cell of islet, and can make the beta Cell of islet regeneration and the reparation of damage.Discover before 'Qimailing ' oral liquid is treated back patient's serum insulin, C peptide level and treatment relatively to be significantly increased that the blood sugar reducing function of prompting 'Qimailing ' oral liquid may be relevant with enhancing beta Cell of islet secretory function.
It is unique that this is filled a prescription, and only road part is arranged, the difference of flavour of a drug and dosage, and treating both the principal and secondary aspects of a disease, evident in efficacy, cheap, taking convenience, characteristics such as few side effects, to preventing the chronic complicating diseases of diabetic, it is quite helpful to improve its survival rate and quality of life.
The present invention has tightly designed the clinical case observation according to WHO diabetes diagnosis standard, has selected observation group and matched group, the statistical procedures of before treating and treatment back observed data.Choose diabetes person's 100 examples of not having the severe complication as subjects.Former therapeutic scheme is constant in the observation process, and diet and quantity of motion are also the same.Usage: the each 20ml of 'Qimailing ' oral liquid, twice of every day is oral, observes 2 months courses of treatment.Observe empty stomach and post-prandial glycemia, insulin, the variation of c peptide before and after the treatment, data are carried out statistical procedures, and measure blood fat, hepatic and renal function, microdose urine protein etc.
The present invention innovates part and also is to adopt the combined therapy of Chinese and Western medicine, utilize 'Qimailing ' oral liquid supplementing QI and nourishing YIN, promoting blood circulation to remove obstruction in the collateral, with oral antidiabetic drug or insulin combination treatment, reach and improve islet cell function, further improve the sensitivity of insulin, steadily blood sugar control is safely and effectively corrected metabolism surely disorderly, stop developing of complication, improve diabetics quality of life.Has good social benefit.And the 'Qimailing ' oral liquid low price, lower by 30% than like product price, be the patient's of economically underdeveloped area Gospel.If the energy mass production puts goods on the market apply, can alleviate the financial burden of diabetics, can bring huge economic benefit to society again.
Clinical data and method
1.1 clinical data
Case derives from the type 2 diabetes mellitus patient.Diagnosis is according to WHO diabetes diagnosis standard in 1998 promptly: " three-many-one-little " symptom such as 1. tangible polydipsia, polyuria, polyphagia are arranged, lose weight, fasting glucose 〉=7.0mmol/L, or the blood glucose that whenever detects in one day it 〉=11.1mmol/L; Though 2. patient does not have tangible diabetic symptom, continuous 2 days fasting glucose all 〉=7.0mmol/L or 2 hours after the meal blood glucose it 〉=11.1mmol/L.Selected case is all by above-mentioned standard diagnostics, and the acute and chronic complication of non-diabetic is divided into 2 groups at random.Therapy of combining Chinese and Western medicine group (hereinafter to be referred as the treatment group) 100 examples, wherein male 43 examples, women 57 examples, at 24～77 years old age, average 52.6 years old, the course of disease was the longest 20 years, the shortest first quarter moon.Western medical treatment group (hereinafter to be referred as matched group) 50 examples, wherein male 20 examples, women 30 examples; At 33～68 years old age, average 50.5 years old, the course of disease was the longest 16 years, and is the shortest 2 days.
1.2 Therapeutic Method
Matched group is taken Western medicine glipizide 2.5～5mg separately, and three times on the one, take before the meal, metformin 0.25～0.5, three times on the one, take after the meal, observe the glycemic control situation.
The treatment group except that take with matched group with the glipizide of dosage, the metformin, take invention side's 'Qimailing ' oral liquid simultaneously, each 20 milliliters, every day 2 times is oral.'Qimailing ' oral liquid side's medicine is formed: Radix Rehmanniae, Radix Trichosanthis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria etc.
Observed the course of disease 2 months, during two groups of patients all give diet control and exercise therapy.
1.3 observation index:
Viewing duration is (FBG) and the 2 hours after the meal fixing SureStep of the Johnson ﹠ Johnson rapid blood sugar instrument mensuration of using of (PBG) blood glucose on an empty stomach, and each time point is surveyed blood glucose 2 times simultaneously, averages.On an empty stomach and 2 hours after the meal insulins, C peptide (F-INS, P-INS, the F-C peptide, the P-C peptide) adopt the isolating immunoenzyme connection algoscopy of magnetic particle (IEMA) on ARIM--ZYME I endocrine quantitative determination instrument (Biochem immunosystem company), to measure, test kit provides INS by Biochem immunosystem company: variation within batch coefficient＜4.2%, interassay coefficient of variation＜6.9%, C peptide: variation within batch coefficient＜5.1%, interassay coefficient of variation＜8.5%.Observe body weight, blood pressure, heart rate, hepatic and renal function, blood fat, hematuria routine and medication reaction in the treatment.
1.4 statistical method
The data of surveying represent that with X ± S relatively with the t check, curative effect is relatively used variance analysis to parameter between two groups before and after observing.
2. result
2.1 comprehensive therapeutic effect analysis
Comprehensive therapeutic effect according to two groups of curative effect judging standard (blood glucose numerical value and basic value are than descending greater than 30% be produce effects after treatment February, and 10～29% be effectively, no change or to reduce below 10% be invalid) analyses.
Treatment group: reduce FBG: produce effects 58 examples, effective 29 examples, invalid 13 examples, total effective rate 87%; Reduce PBG: produce effects 60 examples, effective 30 examples, invalid 10 examples, total effective rate 90%.
Matched group: reduce FBG: produce effects 14 examples, effective 21 examples, invalid 15 examples, total effective rate 70%; Reduce PBG: produce effects 12 examples, effective 30 examples, invalid 8 examples, total effective rate 84%.
Analyze relatively treatment group and matched group with Ridit, the result is P＜0.01, and the effect that treatment group FBG, PBG reduce is better than matched group very significantly.
2.2 two groups of variations for the treatment of front and back FBG and PBG:
As shown in table 1, before the treatment fasting blood sugar of matched group and treatment group be respectively 10.91 ± 2.95,11.05 ± 2.81mmol/L, postprandial plasma glucose level is respectively 15.12 ± 3.03,14.79 ± 3.57mmol/L, and two groups of blood glucose basic value no difference of science of statistics (p＞0.05) have comparability.Two groups of empty stomaches in treatment back and level of postprandial blood sugar all significantly reduce (p＜0.01) than treatment is preceding, and the treatment group blood glucose fall of use 'Qimailing ' oral liquid treatment is bigger, than difference statistical significance (p＜0.01) is arranged with matched group.
The two groups of blood glucose comparisons in table 1 treatment front and back (x ± s)
Table 1 The comparison of plasma blood glucose levels before and after treatment
| Group Group | Case load N | FBG(mmol/L) | PBG(mmol/L) | ||
| Before the treatment | After the treatment | Before the treatment | After the treatment | ||
| The treatment of control group group | 50 100 | 10.91±2.95 11.05±2.81 | 8.62±2.49 + 7.31±2.39 +* | 15.12+3.03 14.79±3.57 | 11.72±2.73 + 10.02±2.46 +* |
Annotate: relatively preceding with treatment, compare a liang group treatment back ,+P＜0.01,
*P＜0.01
vs pretreatment+P＜0.01；vs after treatment between group
*P＜0.01
2.3 two groups of variations for the treatment of front and back serum insulin, C peptide concentration:
No matter be that simple western medicine treatment or therapy of combining Chinese and Western medicine all can make serum insulin and C peptide raise.Treatment group insulin and C peptide level with the 'Qimailing ' oral liquid treatment are high slightly than matched group, but two groups of numerical value difference do not have significance (p＞0.05), see Table 2.
Two groups of serum insulins, C peptide (x ± s) relatively before and after table 2 treatment
Table 2 The comparison of plasma insulin、c-peptide levels before and after treatment
| Project Items | Matched group (n=50) | Treatment group (n=100) | ||
| Before the treatment | After the treatment | Before the treatment | After the treatment | |
| Insulin (μ Iu/ml) empty stomach is C peptide (ng/ml) after the meal | 10.16±5.25 28.73±16.29 | 10.61±4.97 + 29.08±16.11 + | 9.78±5.78 30.23±19.27 | 11.21±5.62 +* 32.73±18.52 +* |
| On an empty stomach after the meal | 1.79±0.90 5.52±2.73 | 1.95±0.87 + 5.98±2.81 + | 1.69±0.88 5.64±2.84 | 1.92±0.87 +* 6.25±2.87 +* |
Annotate: relatively preceding with treatment, compare a liang group treatment back ,+P＜0.01,
*P＞0.05
vs pretreatment+P＜0.01；vs after treatment between group
*P＜0.01
2.4 two groups of influences for the treatment of to blood fat
Reducing before the low-density lipoprotein white level is treated after the treatment of control group, all the other indexs change does not show (p＞0.05).After the treatment group 'Qimailing ' oral liquid treatment 2 months, triglyceride, low density lipoprotein, LDL obviously reduce before the treatment, high density lipoprotein obviously raise (p＜0.01).The blood lipid level of treatment back treatment group also has significant difference (p＜0.05) with matched group than difference, sees Table 3.
The two groups of blood fat comparisons in table 3 treatment front and back (mmol/L, x ± s)
Table 3 The comparison of plasma lipid levels before and after treatment
| Project | Matched group (n=50) | Treatment group (n=100) | ||
| Before the treatment | After the treatment | Before the treatment | After the treatment | |
| T-CHOL (CHO) triglycerides (TG) low-density lipoprotein (LDL) HDL (HDL) | 5.52±1.01 2.42±1.30 3.75±0.99 1.08±0.24 | 4.97±0.79 1.78±0.64 3.19±0.78 + 1.15±0.19 | 5.43±1.04 2.89±2.45 3.62±1.15 0.93±0.21 | 5.17±4.91 1.52±0.59 +* 2.81±0.74 +* 1.07±0.19 +* |
Annotate: relatively preceding with treatment, compare a liang group treatment back ,+P＜0.01,
*P＜0.05
vs pretreatment+P＜0.01；vs after treatment between group
*P＜0.01
2.5 untoward reaction
The observed adverse events of entire test is mainly digestive tract reaction.Only having 3 examples times of defecation to occur in the 100 routine type 2 diabetes mellitus patients that take 'Qimailing ' oral liquid increases.Stool routine examination, liver, all no abnormal change of renal function before and after two groups of treatments.
Case one
Grandson * *, woman, 60 years old.Suffered from diabetes 3 years, extremity acupuncture sample pain, numbness 1 year.Clothes 'Qimailing ' oral liquid before measurement fasting glucose 10.0mmol/L, post-prandial glycemia 12.7mmol/L, cholesterol 5.72mmol/L, triglyceride 2.47mmol/L, high density lipoprotein 0.9mmol/L, fasting insulin 11.64 μ IU/ml, 2 hours after the meal insulin 40.55 μ IU/ml, empty stomach C peptide 1.81ng/ml, 2 hours after the meal C peptides 3.94.Treatment back remission, corresponding data is 4.33mmol/L, 7.45mmol/L, 3.84mmol/L, 1.72mmol/L, 1.53mmol/L, 27.3 μ IU/ml, 57.2 μ IU/ml, 2.67ng/ml, 7.76ng/ml.
Case two
Yellow * *, man, 53 years old.Excessive thirst, polydipsia, polyuria 2 months are diagnosed as diabetes.Give 'Qimailing ' oral liquid before measurement fasting glucose 15.1mmol/L, post-prandial glycemia 17.16mmol/L, cholesterol 6.37mmol/L, triglyceride 2.44mmol/L, HDL1 .02mmol/L, fasting insulin 14.85 μ IU/ml, 2 hours after the meal insulin 41.18 μ IU/ml, empty stomach C peptide 1.94ng/ml, 2 hours after the meal C peptides 6.75.Treatment back symptom obviously alleviates, and corresponding data is 7.34mmol/L, 11.5mmol/L, 5.25mmol/L, 1.32mmol/L, 1.1mmol/L, 19.26 μ IU/ml, 64.27 μ IU/ml, 2.66ng/ml, 8.43ng/ml.
Because the diabetes spp traditional Chinese medical science category of " quenching one's thirst ", motherland's medical science thinks that pathogenic factor is an innate deficiency, and disorder of emotion, eating and drinking without temperance, work and rest are excessive, and treatment should the YIN nourishing spleen reinforcing, transfer liver, temperance for food and drink and having regular daily life.Motherland's medical science is accumulating extremely abundant clinical experience aspect the treatment diabetes, and has modern medicine to be difficult to alternate unique distinction." taking stopgap measures " mainly emphasized in the modern medicine treatment, and mainly by stimulating insulin secretion, biguanides mainly is to reduce hepatic glycogen to decompose, increase to organize and utilize glucose to come blood sugar lowering to present oral sulphanylureas commonly used.And the traditional Chinese medical science is emphasized " effecting a permanent cure ", by supplementing QI and nourishing YIN, reaches the effect of conditioning blood glucose, and therapy of combining Chinese and Western medicine may be passed through " treating both the principal and secondary aspects of a disease " more effectively blood sugar control.
The 'Qimailing ' oral liquid energy clearing heat and moistening dryness of invention, YIN nourishing and the production of body fluid promoting, benefiting QI for activating blood circulation, YIN nourishing is reinforced the kidney, enhance immunity.We reuse Radix Rehmanniae, Radix Ophiopogonis, pollen, and the Kidney-Yin kidney-Yang of nourishing kidney is gone into lung stomach kidney channel, YIN nourishing and the production of body fluid promoting, clearing heat and moistening dryness; The Radix Astragali, Rhizoma Dioscoreae benefiting QI for activating blood circulation, the spleen reinforcing yang invigorating is inspired gastric qi, on can promote the production of body fluid, kind controlling quenched one's thirst; With the spleen invigorating of Poria dampness removing; Cortex Moutan rushes down part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels FUSHUI, full side is mended and oiliness.Modern pharmacological research finds that the single medicinal material of QI invigorating such as the Radix Astragali, Radix Ophiopogonis, Rhizoma Dioscoreae, the Rhizoma Atractylodis Macrocephalae, Poria, spleen invigorating all has the effect of blood sugar lowering.Animal experiment confirms that also spleen invigorating blood sugar lowering class Chinese medicine can not only stimulate the secretory function of beta Cell of islet, and can make the beta Cell of islet regeneration and the reparation of damage.Originally discover before 'Qimailing ' oral liquid is treated back patient's serum insulin, C peptide level and treatment relatively to be significantly increased that the blood sugar reducing function of prompting 'Qimailing ' oral liquid may be relevant with enhancing beta Cell of islet secretory function.Have the report Radix Astragali to also have blood pressure lowering, blood fat reducing in addition, part is corrected the early stage hemodynamics of diabetic nephropathy and is changed, and delays and stop the effect of diabetic complication.
From two groups of treatment observed results as can be seen, list, all descends obviously not as Chinese medicine and western medicine group (treatment group) though blood sugar level has obvious decline with Western medicine group (matched group).And when obtaining good glycemic control, therapy of combining Chinese and Western medicine does not increase the generation of other adverse events such as hypoglycemia.
The specific embodiment
The invention will be further described below in conjunction with the specific embodiment.
Embodiment 1:
Prescription of the present invention, by weight, each composition is: 130 parts of the Radixs Astragali, 130 parts of the Rhizoma Atractylodis Macrocephalaes, 280 parts of Radix Trichosanthis, 280 parts of Radix Rehmanniae, 280 parts of Rhizoma Dioscoreaes, 80 parts of Radix Codonopsis, 80 parts of Radix Ophiopogonis, 180 parts of the Rhizoma Anemarrhenaes, 180 parts of Cortex Moutans, 280 parts of Radix Salviae Miltiorrhizaes, 80 parts in Poria.
Embodiment 2:
Prescription of the present invention, by weight, each composition is: 150 parts of the Radixs Astragali, 150 parts of the Rhizoma Atractylodis Macrocephalaes, 300 parts of Radix Trichosanthis, 300 parts of Radix Rehmanniae, 300 parts of Rhizoma Dioscoreaes, 100 parts of Radix Codonopsis, 100 parts of Radix Ophiopogonis, 200 parts of the Rhizoma Anemarrhenaes, 200 parts of Cortex Moutans, 300 parts of Radix Salviae Miltiorrhizaes, 100 parts in Poria.
Embodiment 3:
Prescription of the present invention, by weight, each composition is: 170 parts of the Radixs Astragali, 170 parts of the Rhizoma Atractylodis Macrocephalaes, 320 parts of Radix Trichosanthis, 320 parts of Radix Rehmanniae, 320 parts of Rhizoma Dioscoreaes, 120 parts of Radix Codonopsis, 120 parts of Radix Ophiopogonis, 220 parts of the Rhizoma Anemarrhenaes, 220 parts of Cortex Moutans, 320 parts of Radix Salviae Miltiorrhizaes, 120 parts in Poria.
Preparation method of the present invention is:
1,, puts into 8-10 times of water and soaked at least 1 hour with above-mentioned ten compositions simply;
2, earlier raw material was decocted 2 hours down at 100 ℃ then, use filtered through gauze, filtrate is stand-by; Filtering residue decocted under 100 ℃ 1.5 hours again, used filtered through gauze then, and filtering residue discards, and two these filtrates are merged, and filtered once more;
3, with gained filtrate under 100 ℃, be concentrated into 800 parts and leave standstill and get final product;
4, gained filtrate is added water to 1000 parts, stir evenly, be filled in the 10ml bottle gland;
5, under 115 ℃, sterilize 0.5 hour promptly.
Claims (9)
1, a kind of 'Qimailing ' oral liquid, it is characterized in that: its constituent by weight, Radix Astragali 130-170 part, Rhizoma Atractylodis Macrocephalae 130-170 part, Radix Trichosanthis 280-320 part, Radix Rehmanniae 280-320 part, Rhizoma Dioscoreae 280-320 part, Radix Codonopsis 80-120 part, Radix Ophiopogonis 80-120 part, Rhizoma Anemarrhenae 180-220 part, Cortex Moutan 180-220 part, Radix Salviae Miltiorrhizae 280-320 part, Poria 80-120 part.
2, 'Qimailing ' oral liquid according to claim 1, it is characterized in that: its constituent by weight, 130 parts of the Radixs Astragali, 130 parts of the Rhizoma Atractylodis Macrocephalaes, 280 parts of Radix Trichosanthis, 280 parts of Radix Rehmanniae, 280 parts of Rhizoma Dioscoreaes, 80 parts of Radix Codonopsis, 80 parts of Radix Ophiopogonis, 180 parts of the Rhizoma Anemarrhenaes, 180 parts of Cortex Moutans, 280 parts of Radix Salviae Miltiorrhizaes, 80 parts in Poria.
3, 'Qimailing ' oral liquid according to claim 1, it is characterized in that: its constituent by weight, 150 parts of the Radixs Astragali, 150 parts of the Rhizoma Atractylodis Macrocephalaes, 300 parts of Radix Trichosanthis, 300 parts of Radix Rehmanniae, 300 parts of Rhizoma Dioscoreaes, 100 parts of Radix Codonopsis, 100 parts of Radix Ophiopogonis, 200 parts of the Rhizoma Anemarrhenaes, 200 parts of Cortex Moutans, 300 parts of Radix Salviae Miltiorrhizaes, 100 parts in Poria.
4, 'Qimailing ' oral liquid according to claim 1, it is characterized in that: its constituent by weight, 170 parts of the Radixs Astragali, 170 parts of the Rhizoma Atractylodis Macrocephalaes, 320 parts of Radix Trichosanthis, 320 parts of Radix Rehmanniae, 320 parts of Rhizoma Dioscoreaes, 120 parts of Radix Codonopsis, 120 parts of Radix Ophiopogonis, 220 parts of the Rhizoma Anemarrhenaes, 220 parts of Cortex Moutans, 320 parts of Radix Salviae Miltiorrhizaes, 120 parts in Poria.
5, the described 'Qimailing ' oral liquid preparation method of a kind of claim 1, it is characterized in that: its method is, with Radix Astragali 130-170 part by weight, Rhizoma Atractylodis Macrocephalae 130-170 part, Radix Trichosanthis 280-320 part, Radix Rehmanniae 280-320 part, Rhizoma Dioscoreae 280-320 part, Radix Codonopsis 80-120 part, Radix Ophiopogonis 80-120 part, Rhizoma Anemarrhenae 180-220 part, Cortex Moutan 180-220 part, Radix Salviae Miltiorrhizae 280-320 part, Poria 80-120 part, decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated, leave standstill, filter, add water to 1000 parts, stir evenly, fill, sterilization, promptly.
6, 'Qimailing ' oral liquid preparation method according to claim 5 is characterized in that: before the described decoction, raw material is put into 8-10 times of water soaked at least 1 hour.
7, 'Qimailing ' oral liquid preparation method according to claim 5 is characterized in that: during described decoction, earlier raw material was decocted 2 hours down at 100 ℃, use filtered through gauze, filtrate is stand-by; Filtering residue decocted under 100 ℃ 1.5 hours again, used filtered through gauze then, and filtering residue discards, and two these filtrates are merged, and filtered once more.
8, 'Qimailing ' oral liquid preparation method according to claim 5 is characterized in that: described when concentrated under 100 ℃, be concentrated into 800 parts and get final product.
9, 'Qimailing ' oral liquid preparation method according to claim 5 is characterized in that: during described sterilization, under 115 ℃, sterilized 0.5 hour.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102727819A (en) * | 2012-07-05 | 2012-10-17 | 陈光明 | Baokangling multi-element probiotics oral liquid for treating digestive system disease and preparation method thereof |
| CN103110807A (en) * | 2013-02-27 | 2013-05-22 | 寇天芹 | Medicine for treating diabetes |
| CN103948786A (en) * | 2014-04-01 | 2014-07-30 | 张默 | Traditional Chinese medicine for treating diabetes |
| CN104524359A (en) * | 2014-12-31 | 2015-04-22 | 吉林省德商药业有限公司 | Traditional Chinese medicine composition and preparing method and application thereof |
| CN114224973A (en) * | 2022-01-13 | 2022-03-25 | 孙天森 | Traditional Chinese medicine composition for treating diabetic ketosis |
Family Cites Families (3)
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| CN1053826C (en) * | 1995-10-04 | 2000-06-28 | 张文龙 | Tonic hypoglycemic capsule and preparing process thereof |
| CN1136893C (en) * | 2001-06-08 | 2004-02-04 | 王显勇 | Medicine for curing diabetes |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727819A (en) * | 2012-07-05 | 2012-10-17 | 陈光明 | Baokangling multi-element probiotics oral liquid for treating digestive system disease and preparation method thereof |
| CN102727819B (en) * | 2012-07-05 | 2014-09-10 | 陈光明 | Baokangling multi-element probiotics oral liquid for treating digestive system disease and preparation method thereof |
| CN103110807A (en) * | 2013-02-27 | 2013-05-22 | 寇天芹 | Medicine for treating diabetes |
| CN103110807B (en) * | 2013-02-27 | 2014-05-28 | 寇天芹 | Medicine for treating diabetes |
| CN103948786A (en) * | 2014-04-01 | 2014-07-30 | 张默 | Traditional Chinese medicine for treating diabetes |
| CN104524359A (en) * | 2014-12-31 | 2015-04-22 | 吉林省德商药业有限公司 | Traditional Chinese medicine composition and preparing method and application thereof |
| CN104524359B (en) * | 2014-12-31 | 2017-08-25 | 吉林省德商药业有限公司 | A kind of Chinese medicine composition, its preparation method and application |
| CN114224973A (en) * | 2022-01-13 | 2022-03-25 | 孙天森 | Traditional Chinese medicine composition for treating diabetic ketosis |
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