CN101002856A - Medicine for treating and preventing cardiovascular and cerebrovascular diseases, and its preparing method - Google Patents
Medicine for treating and preventing cardiovascular and cerebrovascular diseases, and its preparing method Download PDFInfo
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Abstract
A Chinese medicine in the form of oral liquid, syrup, capsule, particle, tablet, or pill for treating and preventing coronary heart disease, pnenmocardial disease, cerebroanoxia and angina pectoris is prepared from 3 Chinese-medicinal materials including rhodiola root, wolfberry fruit, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of is the raw material treatment of making and prevention cardiovascular and cerebrovascular diseases medicament and preparation method thereof with the crude drug.Belong to pharmaceutical sanitary field.
Background technology
Cardiovascular and cerebrovascular disease is the first disease that threatens human health.The medicine of countries in the world active development treatment and prevention cardiovascular and cerebrovascular disease.Along with the reach of science, the medicine of its treatment and prevention constantly increases.But the natural drug based on theory of Chinese medical science is less, does not more have the medicine that adopts supplementing QI and nourishing YIN phlegm reduction of blood circulation promoting medicament composing prescription to carry out systematic treating and improve symptom.
High altitude erythrocytosis is the bigger commonly encountered diseases of highlands health risk, frequently-occurring disease, and its clinical symptoms and sign are usually expressed as: headache, dizzy, tired, uncomfortable in chest, cardiopalmus, out of breath, cyanosis, hyperemia is levied and many blood face etc.Although done a large amount of effort aspect two of rationale and clinical researches, existing treatment and prophylactic agent curative effect are sure and certain toxic and side effects arranged.
Summary of the invention
The object of the invention first purpose is to provide a kind of treatment and prevention cardiovascular and cerebrovascular diseases medicament and preparation method thereof.Another object of the present invention is to provide the preparation method of preparation treatment and prevention cardiovascular and cerebrovascular diseases medicament oral solid formulation.Another purpose of the present invention is to provide the preparation method of preparation treatment and prevention cardiovascular and cerebrovascular diseases medicament liquid preparation.
The present invention is that with supplementing QI and nourishing YIN, phlegm reduction of blood circulation promoting carries out prescription and screening, and invents through the animal experiment and the human clinical trial of strictness according to China's traditional medicine and Tibetan medicine and pharmacology and in conjunction with modern medical theory.
The present invention is that prescription monarch drug, Chinese medicine Fructus Hippophae and Fructus Lycii are adjuvant with the Tibetan medicine Radix Rhodiolae, three flavor medicine compatibilities have invigorate blood circulation, QI invigorating, yin nourishing, expectorant function.Radix Rhodiolae master cool in nature fall, and acrid in the mouth is dispersed, and little bitterness has broken heavily fortified point, removing food stagnancy, invigorates blood circulation, nourishes blood, removing blood stasis, the sanguimotor effect of improvement.Modern pharmacological research proof Radix Rhodiolae contains 2 kinds of different superoxide dismutase (SOD) isozyme, has the ability of stronger removing oxygen-derived free radicals, has clear and definite, sure anti-high altitude anoxia effect.Fructus Hippophae contains vinegar willow ketone, has the effect that reduces blood viscosity, can improve hemorheology, promotes the heart, cerebral blood circulation.Fructus Lycii has certain blood fat reducing, blood glucose effect.
The present invention can improve microenvironment in the erythrocyte membrane, improves the oxygen carrier amount of body hemoglobin.And the reduction blood viscosity, the mediation microcirculation helps the tissue oxygenation supply.Especially cardiac muscle, brain tissue oxygen stop platelet aggregation for improving, and promote the endothelium relaxing factor to discharge, and reduce cholesterol at blood vessel wall deposition and hypertension thrombotic disease preventive and therapeutic effect.The present invention is used for the treatment of and prevents various diseases due to coronary heart disease, pulmonary heart disease, altitude sickness, myocardial ischemia, the microcirculation disturbance, and because of air anoxia and the overtired cardiopalmus that causes, dizziness, disease such as forgetful.
Cardiovascular and cerebrovascular disease of the present invention comprises altitude sickness and high altitude erythrocytosis.This disease is the bigger commonly encountered diseases of highlands health risk, frequently-occurring disease, and its clinical symptoms and sign are usually expressed as: headache, dizzy, tired, uncomfortable in chest, cardiopalmus, out of breath, cyanosis, hyperemia is levied and many blood face etc.The present invention can significantly improve the brain tissue oxygen confession, thereby rapidly alleviates headache, dizzy, tired, uncomfortable in chest, cardiopalmus, out of breath, cyanosis, hyperemia are levied etc., and react and high altitude erythrocytosis on the plateau.
First purpose of the present invention realizes by following steps:
The present invention adopts the medical material of following weight parts proportioning to make:
Radix Rhodiolae 5-30 Fructus Lycii 2-15 fresh syrup of Fructrs Hippophae 1-3
The preferable weight portion proportioning of its described medical material is Radix Rhodiolae 8-12 Fructus Lycii 3-8 fresh syrup of Fructrs Hippophae 1.2-2
Its described medical material optimum weight part proportioning is Radix Rhodiolae 10 Fructus Lycii 5 fresh syrup of Fructrs Hippophae 1.43
The preparation method of the oral solid formulation of another object of the present invention treatment and prevention cardiovascular and cerebrovascular diseases medicament realizes by following steps:
Medical material with the following weight parts proportioning is made: Radix Rhodiolae 5-30, Fructus Lycii 2-15, fresh syrup of Fructrs Hippophae 1-3.
Its preparation technology's method can be:
A: Radix Rhodiolae adds ethanol extraction 1-4 time, and merge extractive liquid, is standby behind the recovery ethanol;
B: Fructus Lycii decocts with water 1-4 time,, collecting decoction filters filtrate for later use;
C: sea-buchthorn fresh fruit squeezing gets that juice filters or the Fructus Hippophae dry fruit is soaked squeezing and got juice and filter and mix with above-mentioned alcohol extract and decocting liquid, and is concentrated, drying, and it is standby to obtain extract powder;
D: get extract powder, adding carboxymethylstach sodium or starch or micropowder silica gel or microcrystalline Cellulose or dextrin are an amount of, granulate, and drying is made on the pharmaceutics and can be accepted oral capsule, granule, tablet, chewable tablet, dispersible tablet, pill.
The preferable preparation method of the oral solid formulation of treatment of the present invention and prevention cardiovascular and cerebrovascular diseases medicament can be to make with the medical material of following weight parts proportioning: Radix Rhodiolae 8-12, Fructus Lycii 3-8, fresh syrup of Fructrs Hippophae 1.2-2.
Its preparation technology's method can be:
A: the Radix Rhodiolae drying, add 3-7 and doubly measure 50-80% ethanol or fresh Radix Rhodiolae and add 3-7 and doubly measure the 80-99% alcohol reflux 1-4 time, backflow 1-4 hour, merge extractive liquid, reclaimed behind the ethanol standby;
B: Fructus Lycii adds 5-10 times of water gaging, decocts 1-4 time, and each 1-4 hour, collecting decoction filtered filtrate for later use;
C: the sea-buchthorn fresh fruit squeezing is got juice and is filtered, or the Fructus Hippophae dry fruit is soaked squeezing and is got juice and filter, mix with above-mentioned alcohol extract and decocting liquid, be evaporated to the clear paste of relative density 1.05～1.20 (50 ℃), spray drying (150～190 ℃ of intake air temperatures, 105～115 ℃ of air outlet temperature), get dry extract;
D: get dry extract, adding carboxymethylstach sodium or starch or micropowder silica gel or microcrystalline Cellulose or dextrin are an amount of, regulate total amount, use alcohol granulation, drying, granulate is made on the pharmaceutics and can be accepted oral capsule, granule, tablet, chewable tablet, dispersible tablet, pill.
The preparation method of the oral solid formulation of above-mentioned treatment and prevention cardiovascular and cerebrovascular diseases medicament, through process conditions and Parameter Optimization screening, obtaining best preparation method is to make with the medical material of following weight parts proportioning: Radix Rhodiolae 10, Fructus Lycii 5, fresh syrup of Fructrs Hippophae 1.43.
Its preparation technology's method can be:
A: the Radix Rhodiolae drying, add 5 times of amount 65-75% ethanol or fresh Radix Rhodiolae, add 3-7 and doubly measure 85-95% reflux, extract, secondary, refluxed 3 hours for the first time, refluxed 2 hours for the second time, merge extractive liquid,, standby behind the recovery ethanol;
B: Fructus Lycii adds 8 times of water gagings, decocts secondary, and each 2 hours, collecting decoction filtered filtrate for later use;
C: sea-buchthorn fresh fruit squeezing gets that juice filters or the Fructus Hippophae dry fruit is soaked squeezing and got juice and filter, mix with above-mentioned alcohol extract and decocting liquid, decompression (0.08MPa, 60～65 ℃) be concentrated into the clear paste of relative density 1.05～1.10 (50 ℃), spray drying (170～180 ℃ of intake air temperatures, 100～110 ℃ of air outlet temperature), dry extract standby;
D: get dry extract, adding carboxymethylstach sodium or starch or micropowder silica gel or microcrystalline Cellulose or dextrin are an amount of, regulate total amount, use 70% alcohol granulation, drying, granulate is made on the pharmaceutics and can be accepted oral capsule, granule, tablet, chewable tablet, dispersible tablet, pill.
The preparation method of another therapeutic interest of the present invention and prevention cardiovascular and cerebrovascular diseases medicament oral liquid realizes by following steps:
Medical material with the following weight parts proportioning is made: Radix Rhodiolae 5-30, Fructus Lycii 2-15, fresh syrup of Fructrs Hippophae 1-3.
Its preparation technology's method can be:
A: Radix Rhodiolae adds ethanol extraction 1-4 time, and merge extractive liquid, is standby behind the recovery ethanol;
B: Fructus Lycii decocts with water 1-4 time, and collecting decoction filters filtrate for later use;
C: sea-buchthorn fresh fruit squeezing is got juice and is filtered, or the Fructus Hippophae dry fruit soaks squeezing and get juice and filter and mixes with above-mentioned alcohol extract and decocting liquid, and filtration, adds water to total amount at adding correctives, adjuvant, makes on the pharmaceutics and can accept oral solutions, syrup.
The preferable preparation method of oral liquid of above-mentioned treatment and prevention cardiovascular and cerebrovascular diseases medicament is to make with the medical material of following weight parts proportioning: Radix Rhodiolae 8-12, Fructus Lycii 3-8, fresh syrup of Fructrs Hippophae 1.2-2.
Its preparation technology's method can be:
A: the Radix Rhodiolae drying, add 3-7 and doubly measure 50-90% ethanol or fresh Radix Rhodiolae and add 3-7 and doubly measure the 70-99% alcohol reflux 1-4 time, backflow 1-4 hour, merge extractive liquid, reclaimed behind the ethanol standby;
B: Fructus Lycii adds 5-10 times of water gaging, decocts 1-4 time, and each 1-4 hour, collecting decoction filtered filtrate for later use;
C: sea-buchthorn fresh fruit squeezing is got juice and is filtered, or the Fructus Hippophae dry fruit soaks squeezing and get juice and filter and mixes with above-mentioned alcohol extract and decocting liquid, and filtration, adds water to total amount at adding correctives, adjuvant, makes on the pharmaceutics and can accept oral solutions, syrup.
The preparation method of the oral liquid of above-mentioned treatment and prevention cardiovascular and cerebrovascular diseases medicament is screened through process conditions and Parameter Optimization, obtains best preparation method and is:
The weight part ratio of each medical material is: Radix Rhodiolae 10, Fructus Lycii 5, fresh syrup of Fructrs Hippophae 1.43.
A: the Radix Rhodiolae drying, add 5 times of amount 65-75% ethanol or fresh Radix Rhodiolae, add 3-7 and doubly measure 85-95% alcohol reflux secondary, refluxed 3 hours for the first time, refluxed 2 hours for the second time, merge extractive liquid,, standby behind the recovery ethanol;
B: Fructus Lycii adds 8 times of water gagings, decocts secondary, and each 2 hours, collecting decoction filtered filtrate for later use;
C: sea-buchthorn fresh fruit squeezing is got juice and is filtered, or the Fructus Hippophae dry fruit soaks squeezing and get juice and filter, and mixes with above-mentioned alcohol extract and decocting liquid, filters, and the adding correctives, adds water to total amount, makes on the pharmaceutics and can accept oral solutions, syrup adjuvant.
The present invention has supplementing QI and nourishing YIN, the phlegm reduction of blood circulation promoting effect.Be specially adapted to deficiency of both vital energy and Yin, dizziness that stagnation of blood stasis causes, headache, cardiopalmus, asthma, weak, the erythrocytosis that anoxia causes is seen the treatment and the prevention of above-mentioned patient.
The specific embodiment further elaborates the present invention below in conjunction with embodiment.
Embodiment one
Take by weighing raw material by following weight portion proportioning:
Radix Rhodiolae 1000g Fructus Lycii 500g fresh syrup of Fructrs Hippophae 143g
Preparation method is as follows:
A: the Radix Rhodiolae drying, add 5 times of amount 70% alcohol reflux secondaries, refluxed 3 hours for the first time, refluxed 2 hours for the second time, merge extractive liquid,, standby behind the recovery ethanol;
B: Fructus Lycii adds 8 times of water gagings, decocts secondary, and each 2 hours, collecting decoction filtered filtrate for later use;
C: the sea-buchthorn fresh fruit squeezing is got juice and is filtered, mix with above-mentioned alcohol extract and decocting liquid, decompression (0.08MPa, 60～65 ℃) be concentrated into the clear paste of relative density 1.05～1.10 (50 ℃), spray drying (170～180 ℃ of intake air temperatures, 100～110 ℃ of air outlet temperature), dry extract standby;
D: get dry extract, adding carboxymethylstach sodium or starch or micropowder silica gel or microcrystalline Cellulose or dextrin are an amount of, regulate total amount, use 70% alcohol granulation, drying, and granulate obtains granule;
E: or in thick extractum, add adjuvant, make granule;
F: granule made on the pharmaceutics can accept oral capsule, granule, tablet, chewable tablet, dispersible tablet, pill.Preparation method is as follows in detail:
A makes 1000 of oral capsules with above-mentioned particles filled capsule.Take 2 at every turn.
B or above-mentioned granule is distributed into 500 bags obtains granule.Take 1 bag at every turn.
C or add lubricant in above-mentioned granule, tabletting makes 1000 in tablet.Take 2 at every turn.
D or add lubricant, aspartame, acidic flavoring agent in above-mentioned granule, tabletting makes 1000 of chewable tablets.Take 2 at every turn.
E or add lubricant, aspartame, acidic flavoring agent, disintegrating agent in above-mentioned granule, tabletting makes 1000 of dispersible tablets.Take 2 at every turn.Disintegrating agent can be carboxymethyl starch sodium, crosslinked carboxymethyl fecula sodium, polyethylene pyrrole Lip river alkane ketone, crosslinked polyethylene pyrrole Lip river alkane ketone, hydroxypropyl cellulose, hydroxypropyl methylcellulose.
F or with thick extractum pill obtains pill.Be distributed into 500 parts, take 1 part at every turn.
Embodiment two:
Take by weighing raw material by following proportioning:
Radix Rhodiolae 1000g Fructus Lycii 500g fresh syrup of Fructrs Hippophae 143g
Preparation method is as follows:
A: fresh Radix Rhodiolae, add 6 times of amount 90% alcohol reflux secondaries, refluxed 3 hours for the first time, refluxed 2 hours for the second time, merge extractive liquid,, standby behind the recovery ethanol;
B: Fructus Lycii adds 8 times of water gagings, decocts secondary, and each 2 hours, collecting decoction filtered filtrate for later use;
C: sea-buchthorn fresh fruit squeezing is got juice and is filtered, and mixes with above-mentioned alcohol extract and decocting liquid, filters, and the adding correctives, adds water to 10000 volume ratios, makes on the pharmaceutics and can accept oral solutions, syrup adjuvant.Preparation method is as follows in detail:
A adds the sucrose of thick extractum weight portion proportioning more than 0.3 and 0.3, adds entry to 5000ml, stirs, and is distributed into every bottle of 10ml, makes the oral syrup agent.Take one bottle is 10ml at every turn.
B adding correctives aspartame or cyclamate, citric acid, essence.Be specially cyclamate 2g, sorbic acid 1g, polyoxyethylene sorbitan monoleate 4g adds entry to 5000ml, and mixing filters, and is distributed into every bottle of 10ml, makes oral liquid.Sterilization, promptly.Take one bottle is 10ml at every turn.
Embodiment three:
Take by weighing raw material by following weight portion proportioning:
Radix Rhodiolae 800g Fructus Lycii 800g fresh syrup of Fructrs Hippophae 200g
Preparation method is as follows:
A: the Radix Rhodiolae drying, add 8 times of amount 60% alcohol reflux secondaries, refluxed 3 hours for the first time, refluxed 2 hours for the second time, merge extractive liquid,, standby behind the recovery ethanol;
B: Fructus Lycii adds 8 times of water gagings, decocts secondary, and each 2 hours, collecting decoction filtered filtrate for later use;
C: more than the Fructus Hippophae dry fruit is soaked and reached in 5 hours, squeezing is got juice and is filtered, mix with above-mentioned alcohol extract and decocting liquid, decompression (0.08MPa, 60～65 ℃) be concentrated into the clear paste of relative density 1.08～1.12 (50 ℃), spray drying (170～180 ℃ of intake air temperatures, 100～110 ℃ of air outlet temperature), it is standby to get dry extract;
D: get dry extract, adding carboxymethylstach sodium or starch or micropowder silica gel or microcrystalline Cellulose or dextrin are an amount of, regulate total amount, use 70% alcohol granulation, drying, and granulate obtains granule;
E: or in thick extractum, add adjuvant, make granule;
F:, make on the pharmaceutics and can accept oral capsule, granule, tablet, chewable tablet, dispersible tablet, pill with the granule mix homogeneously.Preparation method is as follows in detail:
A makes 1000 of oral capsules with above-mentioned particles filled capsule.Take 2 at every turn.
B or above-mentioned granule is distributed into 500 bags obtains granule.Take 1 bag at every turn.
C or add lubricant in above-mentioned granule, tabletting makes 1000 in tablet.Take 2 at every turn.
D or add lubricant, aspartame, acidic flavoring agent in above-mentioned granule, tabletting makes 1000 of chewable tablets.Take 2 at every turn.
E or in above-mentioned granule, add lubricant, aspartame, acidic flavoring agent, disintegrating agent, tabletting makes 1000 of dispersible tablets.Take 2 at every turn.Disintegrating agent can be carboxymethyl starch sodium, crosslinked carboxymethyl fecula sodium, polyethylene pyrrole Lip river alkane ketone, crosslinked polyethylene pyrrole Lip river alkane ketone, hydroxypropyl cellulose, hydroxypropyl methylcellulose.
G: or, obtain pill with thick extractum pill.Be distributed into 500 parts, take 1 part at every turn.
The present invention has the present invention and has supplementing QI and nourishing YIN, the phlegm reduction of blood circulation promoting effect.Be specially adapted to deficiency of both vital energy and Yin, dizziness that stagnation of blood stasis causes, headache, cardiopalmus, asthma, weak, the erythrocytosis that anoxia causes is seen the treatment and the prevention of above-mentioned patient.Set forth good effect of the present invention below:
The present invention is applicable to treatment and prevention coronary heart disease and alleviation and minimizing angina pectoris attacks.Classical angina outbreak and electrocardiogram or myocardium radioisotope scanning show that the myocardial ischemia or the treadmill exercise positive or selective coronary arteriography show the coronary stricture changer, every day an oral 4-8 dosage unit medicine of the present invention 4 week and more than 4 weeks, its blood rheology parameter comprises whole blood viscosity (high shear, low shear), plasma viscosity, factor I and all significantly reductions of hematocrit.The angina pectoris attacks number of times significantly reduces with the angina pectoris attacks persistent period obviously shortens at every turn weekly.Total effective rate is up to 90%.The effect of its treatment coronary heart disease main with prescription in the contained superoxide dismutase of Radix Rhodiolae (SOD) isozyme remove oxygen-derived free radicals, thereby recover and improve vascular endothelial function, help vasodilation, the promotion blood supply of cardiac muscle is relevant.The obvious improvement of the back hemorheology index vinegar willow ketolysis main and that Fructus Hippophae is contained of taking medicine is relevant, can further promote the heart, cerebral blood circulation, works in coordination with the effect that angina pectoris is treated in performance with Radix Rhodiolae.Have no adverse reaction.
The present invention also is applicable to the treatment transient ischemic attack.Every day an oral 4-8 dosage unit medicine of the present invention 4 week and more than 4 weeks, the curative effect of improving transient ischemic attack is close with oral flunarizine matched group curative effect.
The present invention is made up of Chinese medicines such as Radix Rhodiolae, Fructus Hippophae and Fructus Lyciis.Radix Rhodiolae is a monarch drug, and master cool in nature falls, and strongly invigorating primordial QI, logical active, the supplementing QI and nourishing YIN of blood blood stasis dispelling are dispersed, had to acrid in the mouth, improves the blood circulation function.The modern pharmacological research Radix Rhodiolae originates from the Qinghai-Tibet Platean, main component is rhodioloside, benzhydryl six oxy picolinates, butyl alcohol and cupreol.Anti-peroxidation, anoxia enduring and endurance are arranged, reduce effects such as brain cell, myocardial cell oxygen consumption, Fructus Hippophae contains the yellow cave of vinegar willow, have the hemodynamics of improvement and hemorheology effect, sea buckthorn fruit have eliminate the phlegm, the effect of relieving cough and asthma, Oleum Hippophae has very strong bactericidal action, can treat upper respiratory tract chronic inflammatory diseases such as pharyngolaryngitis, tonsillitis.Fructus Lycii has the effect of certain blood fat reducing and blood glucose.Studies confirm that healthy people and high altitude erythrocytosis person take PaO behind the medicine of the present invention that three medicines form
2And SaO
2Obviously raise; Microenvironment improves in the erythrocyte membrane, and the oxygen carrier amount of body hemoglobin improves.And the reduction blood viscosity, the mediation microcirculation helps the tissue oxygenation supply.Especially cardiac muscle, brain tissue oxygen stop platelet aggregation for improving, and promote the endothelium relaxing factor to discharge, and reduce cholesterol and have preventive and therapeutic effect in the blood vessel wall deposition and to the hypertension thrombotic disease.Therefore, the present invention has the various diseases due to treatment and prevention coronary heart disease, pulmonary heart disease, altitude sickness, myocardial ischemia, TIA, the microcirculation disturbance, and because of air anoxia and the overtired cardiopalmus that causes, dizziness, disease such as forgetful.
Claims (10)
1. treat and the prevention cardiovascular and cerebrovascular diseases medicament for one kind, it is characterized in that making with the medical material of following weight parts proportioning:
Radix Rhodiolae 5-30 Fructus Lycii 2-15 fresh syrup of Fructrs Hippophae 1-3.
2. treatment as claimed in claim 1 and prevention cardiovascular and cerebrovascular diseases medicament is characterized in that the preferable weight portion proportioning of described medical material is:
Radix Rhodiolae 8-12 Fructus Lycii 3-8 fresh syrup of Fructrs Hippophae 1.2-2.
3. as claim 1 and 2 described treatments and prevention cardiovascular and cerebrovascular diseases medicament, it is characterized in that described medical material optimum weight part proportioning is:
Radix Rhodiolae 10 Fructus Lycii 5 fresh syrup of Fructrs Hippophae 1.43.
4. preparation method as the oral solid formulation of claim 1 and 2 and 3 described treatments and prevention cardiovascular and cerebrovascular diseases medicament is characterized in that:
A: Radix Rhodiolae adds ethanol extraction 1-4 time, and merge extractive liquid, is standby behind the recovery ethanol;
B: Fructus Lycii decocts with water 1-4 time, and collecting decoction filters filtrate for later use;
C: sea-buchthorn fresh fruit squeezing gets that juice filters or the Fructus Hippophae dry fruit is soaked squeezing and got juice and filter and mix with above-mentioned alcohol extract and decocting liquid, and is concentrated, drying, and it is standby to obtain extract powder;
D: get extract powder, adding carboxymethylstach sodium or starch or micropowder silica gel or microcrystalline Cellulose or dextrin are an amount of, granulate, and drying is made on the pharmaceutics and can be accepted oral capsule, granule, tablet, chewable tablet, dispersible tablet, pill.
5. the feature of the preferable preparation method of the oral solid formulation of treatment as claimed in claim 4 and prevention cardiovascular and cerebrovascular diseases medicament is:
A: the Radix Rhodiolae drying, add 3-7 and doubly measure 50-80% ethanol or fresh Radix Rhodiolae and add 3-7 and doubly measure the 80-99% alcohol reflux 1-4 time, backflow 1-4 hour, merge extractive liquid, reclaimed behind the ethanol standby;
B: Fructus Lycii adds 5-10 times of water gaging, decocts 1-4 time, and each 1-4 hour, collecting decoction filtered filtrate for later use;
C: the sea-buchthorn fresh fruit squeezing is got juice and is filtered, or the Fructus Hippophae dry fruit is soaked squeezing and is got juice and filter, mix with above-mentioned alcohol extract and decocting liquid, be evaporated to the clear paste of relative density 1.05～1.20 (50 ℃), spray drying (150～190 ℃ of intake air temperatures, 105～115 ℃ of air outlet temperature), get dry extract;
D: get dry extract, adding carboxymethylstach sodium or starch or micropowder silica gel or microcrystalline Cellulose or dextrin are an amount of, regulate total amount, use alcohol granulation, drying, granulate is made on the pharmaceutics and can be accepted oral capsule, granule, tablet, chewable tablet, dispersible tablet, pill.
6. the feature as the best preparation method of oral solid formulation of claim 4 and 5 described treatments and prevention cardiovascular and cerebrovascular diseases medicament is:
A: the Radix Rhodiolae drying, add 5 times of amount 65-75% ethanol or fresh Radix Rhodiolae, add 3-7 and doubly measure 85-95% reflux, extract, secondary, refluxed 3 hours for the first time, refluxed 2 hours for the second time, merge extractive liquid,, standby behind the recovery ethanol;
B: Fructus Lycii adds 8 times of water gagings, decocts secondary, and each 2 hours, collecting decoction filtered filtrate for later use;
C: sea-buchthorn fresh fruit squeezing gets that juice filters or the Fructus Hippophae dry fruit is soaked squeezing and got juice and filter, mix with above-mentioned alcohol extract and decocting liquid, decompression (0.08MPa, 60～65 ℃) be concentrated into the clear paste of relative density 1.05～1.10 (50 ℃), spray drying (170～180 ℃ of intake air temperatures, 100～110 ℃ of air outlet temperature), dry extract standby;
D: get dry extract, adding carboxymethylstach sodium or starch or micropowder silica gel or microcrystalline Cellulose or dextrin are an amount of, regulate total amount, use 70% alcohol granulation, drying, granulate is made on the pharmaceutics and can be accepted oral capsule, granule, tablet, chewable tablet, dispersible tablet, pill.
7. preparation method as the oral liquid of claim 1 and 2 and 3 described treatments and prevention cardiovascular and cerebrovascular diseases medicament is characterized in that:
A: Radix Rhodiolae adds ethanol extraction 1-4 time, and merge extractive liquid, is standby behind the recovery ethanol;
B: Fructus Lycii decocts with water 1-4 time, and collecting decoction filters filtrate for later use;
C: sea-buchthorn fresh fruit squeezing is got juice and is filtered, or the Fructus Hippophae dry fruit soaks squeezing and get juice and filter and mixes with above-mentioned alcohol extract and decocting liquid, and filtration, adds water to total amount at adding correctives, adjuvant, makes on the pharmaceutics and can accept oral solutions, syrup.
8. the feature of the preferable preparation method of oral liquid of treatment as claimed in claim 7 and prevention cardiovascular and cerebrovascular diseases medicament is:
A: the Radix Rhodiolae drying, add 3-7 and doubly measure 50-90% ethanol or fresh Radix Rhodiolae and add 3-7 and doubly measure the 70-99% alcohol reflux 1-4 time, backflow 1-4 hour, merge extractive liquid, reclaimed behind the ethanol standby;
B: Fructus Lycii adds 5-10 times of water gaging, decocts 1-4 time, and each 1-4 hour, collecting decoction filtered filtrate for later use;
C: sea-buchthorn fresh fruit squeezing is got juice and is filtered, or the Fructus Hippophae dry fruit soaks squeezing and get juice and filter and mixes with above-mentioned alcohol extract and decocting liquid, and filtration, adds water to total amount at adding correctives, adjuvant, makes on the pharmaceutics and can accept oral solutions, syrup.
9. the feature as the best preparation method of oral liquid of claim 4 and 5 described treatments and prevention cardiovascular and cerebrovascular diseases medicament is:
A: the dry dry extract that gets of Radix Rhodiolae, add 5 times of amount 65-75% ethanol or fresh Radix Rhodiolae, add 3-7 and doubly measure 85-95% alcohol reflux secondary, refluxed 3 hours for the first time, refluxed 2 hours for the second time, merge extractive liquid,, standby behind the recovery ethanol;
B: Fructus Lycii adds 8 times of water gagings, decocts secondary, and each 2 hours, collecting decoction filtered filtrate for later use;
C: sea-buchthorn fresh fruit squeezing is got juice and is filtered, or the Fructus Hippophae dry fruit soaks squeezing and get juice and filter, and mixes with above-mentioned alcohol extract and decocting liquid, filters, and adding correctives, adjuvant, adds water to total amount, makes on the pharmaceutics and can accept oral solutions, syrup.
10. as claim 1 and 2 and 3 and 4 and 7 described treatments and prevention cardiovascular and cerebrovascular diseases medicament and pharmaceutical preparation thereof, it is characterized in that supplementing QI and nourishing YIN, phlegm reduction of blood circulation promoting, be specially adapted to treatment and prevention coronary heart disease and pulmonary heart disease and cerebral anoxia, allevating angina pectoris, to deficiency of both vital energy and Yin, dizziness that stagnation of blood stasis causes, headache, cardiopalmus, asthma, weak, the erythrocytosis that anoxia causes is seen the treatment and the prevention of above-mentioned patient.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101289494B (en) * | 2007-04-19 | 2011-02-09 | 北京博恩特药业有限公司 | Cyclic peptides with vasodilator action, preparation and uses thereof |
| CN103316151A (en) * | 2013-07-08 | 2013-09-25 | 三普药业股份有限公司 | Combined drug of rhodiola rosea extract, medlar extract and sea-buckthorn fresh pulp powder extract as well al preparation and application thereof |
| CN103520363A (en) * | 2013-09-04 | 2014-01-22 | 三普药业有限公司 | Application of Xinnaoxin capsules in preparation of medicament for treating cerebral ischemia |
| CN105079099A (en) * | 2015-09-09 | 2015-11-25 | 白玛仁增 | Compound Tibetan medicine for treating cardiovascular and cerebrovascular diseases |
| CN105147866A (en) * | 2015-10-13 | 2015-12-16 | 北京普瑞博思投资有限公司 | Traditional Chinese medicine composition for improving cerebral circulation and atherosclerosis and application thereof |
| CN112618507A (en) * | 2021-01-19 | 2021-04-09 | 成都晶博生物科技有限责任公司 | Preparation method of Xinnaoxin tablet |
-
2006
- 2006-01-17 CN CN 200610020168 patent/CN101002856A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101289494B (en) * | 2007-04-19 | 2011-02-09 | 北京博恩特药业有限公司 | Cyclic peptides with vasodilator action, preparation and uses thereof |
| CN103316151A (en) * | 2013-07-08 | 2013-09-25 | 三普药业股份有限公司 | Combined drug of rhodiola rosea extract, medlar extract and sea-buckthorn fresh pulp powder extract as well al preparation and application thereof |
| CN103316151B (en) * | 2013-07-08 | 2015-04-22 | 三普药业有限公司 | Combined drug of rhodiola rosea extract, medlar extract and sea-buckthorn fresh pulp powder extract as well al preparation and application thereof |
| CN103520363A (en) * | 2013-09-04 | 2014-01-22 | 三普药业有限公司 | Application of Xinnaoxin capsules in preparation of medicament for treating cerebral ischemia |
| CN105079099A (en) * | 2015-09-09 | 2015-11-25 | 白玛仁增 | Compound Tibetan medicine for treating cardiovascular and cerebrovascular diseases |
| CN105147866A (en) * | 2015-10-13 | 2015-12-16 | 北京普瑞博思投资有限公司 | Traditional Chinese medicine composition for improving cerebral circulation and atherosclerosis and application thereof |
| CN112618507A (en) * | 2021-01-19 | 2021-04-09 | 成都晶博生物科技有限责任公司 | Preparation method of Xinnaoxin tablet |
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