CN100591388C - Method of preparing micro needle array syringe - Google Patents
Method of preparing micro needle array syringe Download PDFInfo
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- CN100591388C CN100591388C CN200810019356.4A CN200810019356A CN100591388C CN 100591388 C CN100591388 C CN 100591388C CN 200810019356 A CN200810019356 A CN 200810019356A CN 100591388 C CN100591388 C CN 100591388C
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Abstract
The invention discloses a preparation method for a micro-needle array injector, which belongs to a field of biological medical apparatus. The method of the invention adopts micrometer fibers and sub-micrometer fibers as a master plate and obtains the high quality micro-needle array injector with controllable length and hollow internal parts through the steps such as the preparation of micro-needlearrays, the control of the length of the micro-needle, the preparation of shell structures of the surface of the micro-needle and the preparation of the hollow structure. The preparation method provided by the invention has the advantages of cheapness, no need of complicated devices or technology, mass fast production, large needle array area and adjustable diameters and lengths. Through the application of the technology, the high-quality cheap micro-needle array injector can be obtained, which leads the expensive skin permeation technology in the field of biological medicine to the mass market through the cost degradation of the micro-needle array injector.
Description
Technical field
The present invention relates to the preparation method of the preparation method, particularly a kind of micro-needle array injection syringe of a kind of nanometer and micron fine structure material.
Background technology
Transdermal administration is the new way of noinvasive administration, because drug absorption is not subjected to gastral influences such as stomach, intestinal, has avoided liver, gastrointestinal first-pass effect effect, has therefore obtained extensive concern both domestic and external, has vast market prospect.The horny layer of skin is the main barrier that medicine enters human body, so the key of transdermal administration is how to break through horny layer and avoid stimulation to skin.Wherein, the microneedle array method is of greatest concern, promptly with the horny layer of micropin transdermal but do not injure skin corium and carry out medicine transmission.The duct of microneedle array manufacturing is micron-sized, and is bigger than the duct of mode gained such as ion implantation, electroporation, therefore can transport macromolecule, supermolecule even the microgranule that is difficult to transdermal, so the micropin manufacturing is the hot research field always.Early stage micropin is solid, stays some ducts on skin, and medicine diffuses into skin along the duct.The latest development trend is that the importing with micropin and medicine etc. combines, form hollow micro-needle array injection syringe, material enters skin along the duct of each micropin inside, this has strengthened the efficient that transports of drug molecule and nanoparticle greatly, conveniently obtains to treat needed medicine and dosage painlessly.Yet, the preparation of empty micropin array at present mainly depends on expensive micro-processing technology, as reactive ion beam etching (RIBE), focused-ion-beam lithography etc., and, for prevention infection, stain etc., a micron pin array all is disposable usually, therefore, said method can not be applied to the preparation of the cheap empty micropin array that can generally use in market, and this has greatly limited its application and scope.
Summary of the invention
Goal of the invention: the purpose of this invention is to provide a kind of technology simply, the micron and the method for making of submicron probe arrays cheaply.
Technical scheme: the preparation method of a kind of micro-needle array injection syringe of the present invention may further comprise the steps:
(1) preparation of micron and submicron solid microneedles array: fiber package is embedded in the polymeric matrix, then with above-mentioned section, put into concentration and be 0.01～40% HF acid etching solution, or to put into concentration be 0.01～80% KOH etchant solution, under 10～90 ℃ of temperature, corroded 10 seconds～72 hours, and formed the needle-like array structure.
(2) control of micropin length: adopt the dissolution with solvents polymeric matrix, or the heating and melting polymeric matrix, or the impression polymeric matrix, or above combination in any, the control micropin exposes the length of polymeric matrix.
(3) micropin surface crust structure preparation: adopt to apply or sputter or chemical plating or plating or PVD or CVD or above method combination in any, obtain metal, inorganic matter or the Organic substance of 50 nanometers～500 micron thickness on the micropin surface.
(4) hollow-core construction micropin preparation: it is 0.01～40% HF acid etching solution that above-mentioned sample is put into concentration, or to put into concentration be 0.01～80% KOH etchant solution, under 10～90 ℃ of temperature, corroded 10 seconds～72 hours, remove solid microneedles, promptly obtain hollow micro-needle array injection syringe.
In step (1), the material of said micron and submicron solid microneedles is a silicon, or glass, or pottery, or the quartz fibre material; Said embedding method is polymerization, or heating and melting, or perfusion, or reaction, or the combination of above method; Said polymeric matrix is a natural macromolecular material, or synthesized polymer material, perhaps the combination of above material.
In step (2), said solvent is CHCl
3, CHCl
2, acetone, toluene, benzene or its combination in any, dissolution time is 1 minute～72 hours; The required temperature of said heating and melting polymeric matrix is to 60～200 ℃, and the time is 1 minute～12 hours; Said method for stamping is pressed into rubber for the microneedle array with step (1) gained, or plastic board, and 100～500 microns of compression distances are peeled off rubber and plastic board then.
In step (3), said metal is a simple metal, or alloy; Said inorganic matter is carbide, oxide, boride, nitride, selenides, fluoride, silicide, or sulfide; Said Organic substance is a natural macromolecular material, or synthesized polymer material, perhaps above combination.
Beneficial effect: the present invention compared with prior art has following outstanding advantage:
1, greatly reduced the preparation cost of micro-needle array injection syringe.
2, do not need expensive complex technology and equipment such as little processing.
3, parameters such as spacing, length of needlepoint between the pin of conveniently regulating and controlling microneedle array.
4, technology is simple, and the place environment is had no special requirements.
5, simple to operate, manufacturing cycle is short.
Description of drawings
Fig. 1 is the sketch map of preparation process of the present invention.Wherein (a) fiber package is embedded in the polymeric matrix; (b) corrosion forms microneedle array; (c) microneedle array of acquisition certain-length; (d) surface crust structure preparation; (e) obtain hollow micro-needle array injection syringe.
Fig. 2 is the sem photograph of the hollow micro-needle array injection syringe for preparing of the present invention.
Fig. 3 is the sem photograph of the hollow micro-needle array injection syringe micropin end for preparing of the present invention.
The specific embodiment
The preparation method of a kind of micro-needle array injection syringe of the present invention, the design that comprises solid microneedles array length, surface crust structure preparation technology is with definite; Determining of corrosive technology and parameter.
Embodiment 1: with the SiO of fibre diameter 100 micron dimensions
2Fibre bundle is put into MMA (polymethyl methacrylate) solution that adds BPO, place water-bath to make polymer cure in 60 ℃ of heat treatment 24h, be cut into the thin slice that thickness is 5mm then, corrode 1h down with 30 ℃ of constant temperature of 40%HF acid solution, the deionized water ultrasonic cleaning can obtain nano needle arrays after the drying.Then put into chloroform soln and dissolve 20min, the PMMA of spin-coating method at surperficial spin coating 20um thickness adopted in dry back, puts into concentration and is 40% HF acid etching solution and corrode 5h under 30 ℃ of temperature, obtains the hollow micro-needle array injection syringe of PMMA material.
Embodiment 2: with the SiO of 8 microns of fibre diameters
2Fibre bundle is put into the styrene solution that adds hexamethylene imine base lithium, places water-bath to make polymer cure in 60 ℃ of heat treatment 24h; Be cut into the thin slice that thickness is 3mm then; 30 ℃ of constant temperature are down with 20%HF acid solution corrosion 30min, and the deionized water ultrasonic cleaning can obtain nano needle arrays after the drying.Then put into chloroform soln and dissolve 5min, the Au of magnetron sputtering method at surface deposition 1um thickness adopted in dry back, puts into concentration and is 40% HF acid etching solution and corrode 5h under 30 ℃ of temperature, and obtaining PS is the Au hollow micro-needle array injection syringe of substrate.
Embodiment 3: with the SiO of 20 microns of fibre diameters
2In molten polystyrene (PS) resin that the fibre bundle immersion is 120 ℃, fill the postcooling section that finishes, 40 ℃ of constant temperature corrode 10min with the 40%HF acid solution down, and the deionized water ultrasonic cleaning can obtain a micron pin array after the drying.Then place polydimethylsiloxane film surface imprint at 90 ℃, adopt the Au of electroless plating method then at surface deposition 2um thickness, put into concentration and be 20% HF acid etching solution and corrode 8h under 40 ℃ of temperature, obtaining PS is the Au hollow micro-needle array injection syringe of substrate.
Embodiment 4: with the SiO of 125 microns of fibre diameters
2Fibre bundle is put into the styrene solution that adds hexamethylene imine base lithium, places water-bath to make polymer cure in 60 ℃ of heat treatment 24h; Be cut into the thin slice that thickness is 5mm then; 30 ℃ of constant temperature are down with 40%HF acid solution corrosion 2.5h, and the deionized water ultrasonic cleaning can obtain nano needle arrays after the drying.Then put into toluene solution and dissolve 30min, dry back is adopted and is lifted coating method coats 20 micron thickness on the surface PMMA, put into concentration then and be 30% HF acid solution and corrode 10h under 20 ℃ of temperature, obtaining PS is the PMMA hollow micro-needle array injection syringe of substrate.
Embodiment 5: with the SiO of 20 microns of fibre diameters
2In molten polystyrene (PS) resin that the fibre bundle immersion is 120 ℃, fill the postcooling section that finishes, 40 ℃ of constant temperature corrode 10min with the 40%HF acid solution down, and the deionized water ultrasonic cleaning can obtain a micron pin array after the drying.Then place polydimethylsiloxane film surface imprint at 90 ℃, adopt the Au of PVD method at surface deposition 5um thickness then, put into concentration and be 10% HF acid etching solution and corrode 8h under 50 ℃ of temperature, obtaining PS is the Au hollow micro-needle array injection syringe of substrate.
Embodiment 6: with the SiO of fibre diameter 100 micron dimensions
2Fibre bundle is put into MMA (polymethyl methacrylate) solution that adds BPO, place water-bath to make polymer cure in 60 ℃ of heat treatment 24h, be cut into the thin slice that thickness is 5mm then, corrode 1h down with 30 ℃ of constant temperature of 40%HF acid solution, the deionized water ultrasonic cleaning can obtain nano needle arrays after the drying.Then put into chloroform soln and dissolve 20min, the PS of spin-coating method at surperficial spin coating 30um thickness adopted in dry back, put into concentration and be 40% HF acid etching solution and corrode 5h under 30 ℃ of temperature, obtaining the PMMA material is substrate, the hollow micro-needle array injection syringe of PS material.
Embodiment 7: the Si fibre bundle of fibre diameter 100 micron dimensions is put into fused melt polypropylene, be cut into the thin slice that thickness is 5mm after the cooling, corrode 3h down with 80 ℃ of constant temperature of 30%KOH solution, the deionized water ultrasonic cleaning can obtain nano needle arrays after the drying.Then put into chloroform soln and dissolve 20min, the PS of spin-coating method at surperficial spin coating 100um thickness adopted in dry back, put into concentration and be 20% KOH solution and corrode 10h under 60 ℃ of temperature, the acquisition polypropylene material is substrate, the hollow micro-needle array injection syringe of PS material.
Embodiment 8: basic step is same as embodiment 1, and different is that fiber is selected glass (also can select fibrous materials such as pottery or quartz for use) for use.
Embodiment 9: basic step is same as embodiment 1, and the concentration of etchant solution HF acid that different is is 0.01%, and corrosion temperature is 20 ℃, and etching time is 72 hours.
Embodiment 10: basic step is same as embodiment 1, and the thickness of different is spin coating PMMA is 1um.
Embodiment 11: basic step is same as embodiment 1, and the thickness of different is spin coating PMMA is 500um.
Embodiment 12: basic step is same as embodiment 1, and different is to adopt to apply and the bonded method of sputter after drying, obtains the Organic substance of 50 micron thickness on the micropin surface.
Embodiment 13: basic step is same as embodiment 1, and different is the combined method that adopts coating and sputter after drying, obtains the inorganic matter of 100 micron thickness on the micropin surface.
Claims (9)
1, a kind of preparation method of micro-needle array injection syringe is characterized in that this method may further comprise the steps:
(1) preparation of micron and submicron solid microneedles array: fiber package is embedded in the polymeric matrix, then with above-mentioned matrix section, put into concentration and be 0.01～40% HF acid etching solution, or to put into concentration be 0.01～80% KOH etchant solution, under 10～90 ℃ of temperature, corroded 10 seconds～72 hours, and formed the needle-like array structure;
(2) control of micropin length: adopt solvent to dissolve above-mentioned needle-like array structure, or heating and melting, or impression, or above combination in any, control the height that micropin exposes polymeric matrix by the requirement of setting;
(3) micropin surface crust structure preparation: adopt to apply, or sputter, or chemical plating, or electroplate, or PVD, or CVD, or above method combination in any, at surperficial inorganic matter or the Organic substance that obtains 50 nanometers～500 micron thickness of micropin;
(4) hollow-core construction micropin preparation: it is 0.01～40% HF acid etching solution that the micropin that above-mentioned surface is had a shell structurre is put into concentration, or to put into concentration be 0.01～80% KOH etchant solution, under 10～90 ℃ of temperature, corroded 10 seconds～72 hours, remove solid microneedles, promptly obtain hollow micro-needle array injection syringe.
2, the preparation method of a kind of micro-needle array injection syringe according to claim 1 is characterized in that in step (1), and the material of said micron and submicron solid microneedles is a silicon, or glass, or pottery, or the quartz fibre material.
3, the preparation method of a kind of micro-needle array injection syringe according to claim 1 is characterized in that in step (1), said embedding method is polymerization, or heating and melting, or perfusion, or the combination of above method.
4, the preparation method of a kind of micro-needle array injection syringe according to claim 1 is characterized in that in step (1), said polymeric matrix is a natural macromolecular material, or synthesized polymer material, perhaps the combination of above material.
5, the preparation method of a kind of micro-needle array injection syringe according to claim 1 is characterized in that in step (2), said solvent is CHCl
3, CH
2Cl
2, acetone, toluene or its combination in any, dissolution time is 1 minute～72 hours.
6, the preparation method of a kind of micro-needle array injection syringe according to claim 1 is characterized in that in step (2) the required temperature of heating and melting polymeric matrix is 60～200 ℃, and the time is 1 minute～12 hours.
7, the preparation method of a kind of micro-needle array injection syringe according to claim 1, it is characterized in that in step (2), said method for stamping is pressed into rubber or plastic board for the microneedle array with step (1) gained, and 100～500 microns of compression distances are peeled off rubber or plastic board then.
8, the preparation method of a kind of micro-needle array injection syringe according to claim 1 is characterized in that in step (3), said inorganic matter is carbide, oxide, boride, nitride, selenides, fluoride, silicide, or sulfide.
9, the preparation method of a kind of micro-needle array injection syringe according to claim 1 is characterized in that in step (3), said Organic substance is a natural macromolecular material, or synthesized polymer material, perhaps above combination.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200810019356.4A CN100591388C (en) | 2008-01-04 | 2008-01-04 | Method of preparing micro needle array syringe |
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| CN200810019356.4A CN100591388C (en) | 2008-01-04 | 2008-01-04 | Method of preparing micro needle array syringe |
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| CN101234221A CN101234221A (en) | 2008-08-06 |
| CN100591388C true CN100591388C (en) | 2010-02-24 |
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101347652B (en) * | 2008-09-09 | 2011-01-12 | 南京大学 | Method for preparing hollow micro-needle array injection syringe |
| CN102000020B (en) * | 2010-11-17 | 2012-10-10 | 河南羚锐制药股份有限公司北京药物研究院 | Novel micro-needle patch containing degradable polymer and preparation method thereof |
| CN102502474A (en) * | 2011-11-10 | 2012-06-20 | 无锡英普林纳米科技有限公司 | Nonplanar micron/submicron microneedle array and method for producing same |
| CN102887477B (en) * | 2012-10-11 | 2015-04-22 | 无锡英普林纳米科技有限公司 | Polymer surface nanowire array and preparation method thereof |
| CN103772721A (en) * | 2012-10-19 | 2014-05-07 | 金陵科技学院 | Making method of novel conical array structure |
| CN103569954A (en) * | 2013-11-12 | 2014-02-12 | 无锡英普林纳米科技有限公司 | Method for preparing micron submicron reaction vessel array |
| CN103569952B (en) * | 2013-11-12 | 2016-01-20 | 无锡英普林纳米科技有限公司 | The preparation method of one-dimensional Polymers periodic micro structure |
| CN103829954B (en) * | 2014-03-04 | 2016-01-20 | 中山大学 | A kind of adhesive type empty micropin array and manufacture method thereof |
| EP3616744A4 (en) * | 2017-04-27 | 2020-05-27 | Think-Lands Co., Ltd. | Microneedle production method |
| CN108328567B (en) * | 2018-01-08 | 2020-07-14 | 东南大学 | Method for obtaining high-density unequal-height crystal microneedle array |
| CN112018213B (en) * | 2020-07-20 | 2022-03-29 | 烟台南山学院 | Preparation method of upright Au nanocone with high adhesion to substrate surface |
| CN113106564B (en) * | 2021-04-07 | 2022-03-08 | 南京工程学院 | Preparation process of thermosensitive polymer artificial muscle fiber |
| CN116519759A (en) * | 2023-03-23 | 2023-08-01 | 清华大学 | Microelectrode and single particle electrode |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6511463B1 (en) * | 1999-11-18 | 2003-01-28 | Jds Uniphase Corporation | Methods of fabricating microneedle arrays using sacrificial molds |
| EP1324691B1 (en) * | 2000-10-13 | 2006-05-10 | Precisense A/S | Optical sensor for in situ measurement of analytes |
| CN1817783A (en) * | 2006-01-06 | 2006-08-16 | 上海纳晶科技有限公司 | Production of microneedles |
-
2008
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6511463B1 (en) * | 1999-11-18 | 2003-01-28 | Jds Uniphase Corporation | Methods of fabricating microneedle arrays using sacrificial molds |
| EP1324691B1 (en) * | 2000-10-13 | 2006-05-10 | Precisense A/S | Optical sensor for in situ measurement of analytes |
| CN1817783A (en) * | 2006-01-06 | 2006-08-16 | 上海纳晶科技有限公司 | Production of microneedles |
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| CN101234221A (en) | 2008-08-06 |
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