CN108066681A - It is a kind of for mongolian medicine patch of infantile hyperpyrexia and preparation method thereof and application method - Google Patents

Abstract

It is particularly a kind of for mongolian medicine patch of infantile hyperpyrexia and preparation method thereof and application method the present invention relates to technical field of medicine.7 soup of anaesthetic E Dun is powder, and when being treated for infantile hyperpyrexia, poor compliance takes difficulty, influences to treat.Above-mentioned oral powder is changed to external use plaster by the present invention, and replaces bulk pharmaceutical chemicals with the extract of each medicinal material, using therapeutic effect more preferably.It has the following advantages that：1st, the degradation of the first pass effect and drug of liver in gastrointestinal tract can be avoided, drug absorption reduces the individual difference of medication from the influence of gastrointestinal factors；2nd, single administration can make drug, into vivo, reduce administration number of times with constant rate for a long time, extend dosing interval；3rd, dosage, autonomous medication are adjusted by changing administration area；4th, there is slow controlled-release effect, drug can slowly be discharged with given pace, so as to form constant blood concentration in skin, be conducive to extend the treatment time of drug.

Description

It is a kind of for mongolian medicine patch of infantile hyperpyrexia and preparation method thereof and application method

Technical field

The present invention relates to technical field of medicine, a kind of particularly mongolian medicine patch and its preparation for infantile hyperpyrexia Method and application method.

Background technology

Anaesthetic E Dun -7 soup（Also known as mire Bu -7 soup）, come from《The happiness of onlooker》, by myrobalan, cape jasmine, Fructus meliae toosendan, building The seven flavor medicines such as perfume, kuh-seng form, and grind to the powder altogether, powder is made, and can promote pyreticosis maturation, convergence, and kill heat evil cures mainly prematurity Heat, epidemic disease heat, the heat that He Yi, blood friendship are fought etc..Traditional powder bitter, when which treats for infantile hyperpyrexia, child patient is complied with Property is poor, takes difficulty, influences to treat.In addition, traditional Oral administration is low there are drug availability, stomach and the secondary work of whole body With it is big the shortcomings that, the infant group particularly easily sent out high fever, liver system developmental immaturity, liver detoxification function is not Foot extends the metabolism of some drugs, the Increased Plasma Half-life of drug, adds the blood concentration and toxic action of drug；Infant Renal function is still immature, and kidney excretion function deficiency, the time lengthening that drug and its decomposition product are detained in vivo adds medicine The toxic side effect of object, it is unfavorable that its growth is developed in heavy dose of, high frequency time medication.

The content of the invention

The purpose of the present invention is：Overcome above-mentioned technical deficiency, propose a kind of to the biocompatibility of skin, gas permeability, again Take off that pulling property is preferable again, and drugloading rate appropriateness, the gel adhesive for the treatment of infantile hyperpyrexia and preparation method thereof that is not easy allergy.

Used technical solution is to solve above-mentioned technical problem：A kind of mongolian medicine patch for infantile hyperpyrexia, it is special Sign is：

【Original side】The patch includes following component by weight：

5 parts of myrobalan,

15 parts of cape jasmine,

15 parts of Fructus meliae toosendan,

10 parts of elecampane,

20 parts of kuh-seng,

15 parts of falsespiraea tree bark,

10 parts of kaempferia galamga.

【Now make】The preparation method of the patch, comprises the following steps：

Sa1：It by myrobalan, cape jasmine, Fructus meliae toosendan, elecampane, kuh-seng, falsespiraea tree bark, kaempferia galamga mixing, is crushed through pulverizer, crosses 100-200 Mesh sieve obtains medicinal powder；

Sa2：30 ~ 100 parts of medical polymer gel is added in into medicinal powder to stir evenly, and obtains ointment；

Sa3：Ointment is coated on non-woven fabrics, then covers adherent layer to get the patch product.

The Fructus meliae toosendan is replaced with water extract or ethanol extract.

The preparation method of the extract is：

Fructus meliae toosendan medicinal material is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, add 60% ethyl alcohol or distilled water, refluxing extraction 3 times, every time 1.5h, filtering, filtrate centrifugation 15min（3000 r/min）, supernatant is taken, drying in 70 DEG C of insulating boxs is put, obtains extract.

The medical polymer gel is cellulose derivative, carbomer, alginate, polyvinyl alcohol, polyvinyl pyrrole One or more in alkanone, tragacanth, gelatin, carragheen.

【Extraction side】The extract of the medicinal material of the patch replaces, i.e.,：

With Fructus Chebulae extract replace myrobalan,

With capejasmine extract replace cape jasmine,

With Sichuan chinaberry extract replace Fructus meliae toosendan,

With Radix Inulae extract replace elecampane,

With shrubby sophora extract replace kuh-seng,

With falsespiraea tree bark extract replace falsespiraea tree bark,

Kaempferia galamga is replaced with kaempferia galamga extract.

【It is mixed carry+river singly carries】The preparation method of the extract is as follows：

Sb1：It by myrobalan, cape jasmine, elecampane, kuh-seng, falsespiraea tree bark, kaempferia galamga mixing, crushes, crosses 20-40 mesh sieves and obtain coarse granule, respectively It is extracted using water, 50-99% ethyl alcohol, ethyl acetate as solvent, merges to obtain extracting solution I；

Sb2：Fructus meliae toosendan is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, extracted respectively using water, 50-75% ethyl alcohol as solvent, Merge to obtain extracting solution II；

Sb3：Extracting solution I, extracting solution II are merged, centrifuges, takes supernatant, dries, obtains total extract；

Sb4：By total extract powder, into medicinal powder, 30 ~ 100 parts of medical polymer gel of addition stirs evenly, and obtains ointment；

Sb5：Ointment is coated on non-woven fabrics, then covers adherent layer to get the patch product.

【Singly carry】The preparation method of the extract is as follows：

【1】Fructus Chebulae extract

Myrobalan medicinal material 5g is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, add 60% ethyl alcohol 36-50mL, refluxing extraction 3 times, every time 1.5h, filtering, filtrate centrifugation 15min (3000 r/min) take supernatant, put drying in 70 DEG C of insulating boxs, obtain extract；

【2】Capejasmine extract

Fructus Gardeniae 15g is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, add 60% ethyl alcohol 36-50mL, refluxing extraction 3 times, every time 1.5h, filtering, filtrate centrifugation 15min (3000 r/min) take supernatant, put drying in 70 DEG C of insulating boxs, obtain extract；

【3】Sichuan chinaberry extract

Fructus meliae toosendan medicinal material 15g is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, 60% ethyl alcohol or distilled water 36-50mL, reflux is added to carry It takes 3 times, each 1.5h, filters, filtrate centrifugation 15min (3000 r/min) takes supernatant, puts in 70 DEG C of insulating boxs and dries It is dry, obtain extract；

【4】Radix Inulae extract

Fetch earth Radix Aucklandiae medicinal material 10g, crushes, and crosses 20-40 mesh sieves and obtains coarse granule, adds 90-99% ethyl alcohol 36-50mL, refluxing extraction 3 Secondary, each 1.5h is filtered, and filtrate centrifugation 15min (3000 r/min) takes supernatant, is put drying in 70 DEG C of insulating boxs, is obtained Extract；

【5】Shrubby sophora extract

Sophora flavescens 20g is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, add 60% ethyl alcohol or dilute hydrochloric acid 36-50mL, refluxing extraction 3 Secondary, each 1.5h is filtered, and filtrate centrifugation 15min (3000 r/min) takes supernatant, is put drying in 70 DEG C of insulating boxs, is obtained Extract；

【6】Falsespiraea tree bark extract

Falsespiraea tree bark medicinal material 15g is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, add 95% ethyl alcohol 36-50mL, refluxing extraction 3 times, often Secondary 1.5h, filtering, filtrate centrifugation 15min (3000 r/min) take supernatant, put drying in 70 DEG C of insulating boxs, must extract Object；

【7】Kaempferia galamga extract

Kaempferia galamga medicinal material 10g is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, add 95% ethyl alcohol 36-50mL, refluxing extraction 3 times, every time 1.5h, filtering, filtrate centrifugation 15min (3000 r/min) take supernatant, put drying in 70 DEG C of insulating boxs, obtain extract.

【Finished patch】The patch includes following auxiliary material by weight：Penetrating agent and/or moisturizer and/or surface-active Agent and/or filler and/or binder.

The penetrating agent for ethyl alcohol, propylene glycol, glycerine, oleic acid, Liquid Macrogol, polyethylene glycol 400, low molecule alcohol, One or more in azone, urea, peppermint, camphor, borneol, eucalyptus oil, selinum oil；

The moisturizer is glycerine, the one or more in propylene glycol, sorbierite, polyethylene glycol；

The surfactant is tween.Water-soluble components and lipid soluble ingredients are included in above-mentioned medicinal material, it is contemplated that defervescence plaster used Usage time is not grown generally, and need to quickly be brought down a fever, and can use surfactant；

The filler is kaolin, the one or more in zinc oxide, superfine silica gel powder, calcium carbonate, bentonite, titanium dioxide；

The binder is gelatin, the one or more in sodium carboxymethylcellulose, polyvinylpyrrolidone.

The weight ratio of the auxiliary material is：

1-10 parts of penetrating agent,

10-30 parts of moisturizer,

0.1-3 parts of surfactant,

0.5-2 parts of filler,

1-3 parts of binder.

【Application method】The application method of the patch is：Drug powder is added in into gel allotment before treatment, is uniformly smeared On non-woven cloth or gauze, corresponding acupuncture point is affixed on, 40 minutes every time, is not moved back, is exchanged cards containing all personal details and become sworn brothers and use again.

The acupuncture point includes：

Water is dashed forward cave：Positioned at the neck of human body, the leading edge of nutator,

Fushe cave：4 cun under lower abdomen, Qizhong, opened by anterior median line 4 cun,

Dazhui acupoint：At spinous process of the seventh cervical vertebrae lower recess,

Quchi acupoint：Elbow arthrogryposis recess,

Nei guan point：On wrist band,

Temple：At eyebrow and tail of the eye intersection,

Yang white cave：One-inch on pupil face eyebrow.

The beneficial effects of the invention are as follows：Oral administration biaavailability is not high, injects, and topical administration larger to blood vessel irritation The percutaneous osmosis of drug is made to reach internal body, is had the following advantages that：

1st, can avoid the degradation of the first pass effect and drug of liver in gastrointestinal tract, drug absorption from gastrointestinal factors shadow It rings, reduces the individual difference of medication；

2nd, single administration can make drug, into vivo, reduce administration number of times with constant rate for a long time, extend dosing interval；

3rd, adjust dosage by changing administration area, reduce inter-individual difference, and patient can autonomous medication, can also be with When discontinue medication；

4th, there is slow controlled-release effect, drug can slowly be discharged with given pace, so as to form constant blood concentration in skin, Be conducive to extend the treatment time of drug.

Specific embodiment

【Embodiment 1：Clinical trial】

Fever is one of most common symptom of Pediatric Clinic, clinically usually by anus temperature>38 DEG C or armpit temperature>37.5 DEG C are defined as sending out Heat, there are two ways to treating infantile hyperpyrexia at present, one kind is Physical temperature-lowering, and another kind is drug cooling, and the two is used in combination It can play a multiplier effect.This experiment is to infantile hyperpyrexia using anaesthetic mire Bu -7 point-applications, joint acetparaminosalol Phenol oral liquid Chinese medicine, 116 child with high fever that selection our hospital accepts for medical treatment during in June, -2017 in June, 2016 are analyzed, Specifically it is reported as follows.

1. data and method

1.1 general information

116 child with high fever that selection our hospital accepts for medical treatment during in June, -2017 in June, 2016 are classified as research object Seminar and control group, every group of example.Two groups of infants all meet high fever diagnostic criteria, and chief complaint is fever, swallows red, cough It coughs, male's infant 59 in this group of infant, women infant 57, it is 3.3 that the age, which is evenly distributed 0.5-12 Sui average age, Year, mean body temperature 39.28, seminar and control group general information compare that there is no significant difference, p>0.05, it is comparable 。

1.2 therapy

Seminar's infant gives the joint acetaminophen oral solution treatment of anaesthetic mire Bu -7 point-applications.Method：Oral pair Paracetamol oral liquid simultaneously, sticks anaesthetic mire Bu -7 at the corresponding acupuncture point of infant body surface.Drug powder is added before treatment Enter gel allotment, be uniformly applied on non-woven cloth or gauze, be affixed on corresponding acupuncture point, 40 minutes every time.Conventional acupoint selection:Yang white Cave, temple, interior pass, Quchi acupoint, Dazhui acupoint, water are dashed forward cave, fushe cave；

Control group gives simple acetaminophen oral solution oral medication.

1.3 observation index

To the more a time point warm armpit situations of change of 30min, 1h, 2h, 4h carry out observation note before two groups of infant treatments and after treatment It records and conscientiously compares.

1.4 efficacy determination

Recovery from illness：Infant high fever clinical symptoms after treatment completely disappear, and temperature recovery has no adverse reaction out to normal level It is existing；

It is effective：Patient after the treatment 4 it is small when the body temperature range of decrease at 2 DEG C or more, and body temperature is maintained within controlled range, is not occurred not Good reaction；

Effectively：Infant treat 4 it is small when after the body temperature range of decrease between 0.5-2 DEG C, with the passage of administration time, on body temperature is gradual It rises；

It is invalid：Infant symptom after treatment is not improved, few patients' even aggravation.

Statistical analysis：All data are analyzed using newest statistics software, and continuous data is all with inspection, skill Art data are all with variance test, with p<0.05, between expression group comparison there is statistical significance there are significant difference.

2. result

2.1 two groups of Comparison of therapeutic

Seminar's treatment total effective rate is 96.55%, and control group treatment total effective rate is 89.65%, and there are significance differences for comparison between group Different p<0.05, there is statistical significance, refer to table 1：

The body temperature comparison of different time points after 2.2 two groups of treatments,

Seminar is all significantly better than control group in the degree of bringing down a fever of different observing time points, and contrast difference is notable between group, p<0.05, With statistical significance.Refer to table 2：

。

3. it discusses

Paracetamol is the metabolite of phenacetin in vivo, has antipyretic, sedation, peripheral blood vessel can be promoted to expand And blood flow speedup, refrigeration function is stronger, effect mitigate and it is lasting, be treatment infantile hyperpyrexia clinical commonly used drug.

The treatment total effective rate of seminar is 96.55%, and the treatment total effective rate of control group is 89.65%, is compared between group Significant difference, p<0.05, there is statistical significance.Seminar is all significantly better than control in the degree of bringing down a fever of different observing time points Group, contrast difference is notable between group, p<0.05, there is statistical significance.It can be seen that seminar's temperature decline speed is significantly faster than that Control group, this shows that anaesthetic mire Bu -7 point-applications joint acetaminophen oral solution treatment infantile hyperpyrexia has and takes effect Soon, safe, action time long clinical treatment feature, it is notable that the two is used in combination clinical effectiveness, compared to control group list Pure acetaminophen oral solution falling temperature method advantage is notable.

In conclusion each systematic growth of children is not perfect, poor to Thermoregulation ability, infantile hyperpyrexia is controlled using injection drug Treating increases pain, is brought down a fever using simple drug cooling or simple physical cooling ineffective.After infant fever, parent is often very It is nervous, it is desirable that doctor tries every possible means body temperature to lower as early as possible, and doctor should bring down a fever according to the state of an illness to determine to give, while to infant man Belong to and make patient explanation, avoid causing unnecessary fear.Anaesthetic mire Bu -7 point-applications joint paracetamol takes orally Liquid treatment infantile hyperpyrexia has the clinical efficacy of highly significant, we utilize illiteracy while with doctor trained in Western medicine oral drug therapy Medicine Point application is brought down a fever, and infant and family members are acceptant, curative effect can be allowed to perform to maximum, good through clinical test compliance, tool There is important clinical generalization value.

【Embodiment 2：Point medicine】

It is as follows by the point selection method of point medicine：

Water is dashed forward cave：Positioned at the neck of human body, the leading edge of nutator,

Fushe cave：4 cun under lower abdomen, Qizhong, opened by anterior median line 4 cun,

Dazhui acupoint：At spinous process of the seventh cervical vertebrae lower recess,

Quchi acupoint：Elbow arthrogryposis recess,

Nei guan point：On wrist band,

Temple：At eyebrow and tail of the eye intersection,

Yang white cave：One-inch on pupil face eyebrow.

The action principle of point-application

Point application therapy is a kind of no traumatic pain acupoint therapy, and due to channels and collaterals, " interior category internal organs, outer network podomere are linked up in table, run through Up and down ", it is the passage of human body ying, wei, qi, xue circular flow, and acupuncture point is then the joint run in access, is not only reflected each dirty The function of internal organs physiological and pathological, while be also the effective stimulus point for the treatment of vital organs of the human body disease.

Thus with point application therapy, body surface acupuncture points on the human body is stimulated and acted on, by the conduction of channels and collaterals, corrects internal organs negative and positive It is inclined contain or decline partially, improve the operation of meridian qi and blood, the physiological function and pathological state to internal organs can generate good treatment with Corrective action achievees the purpose that get rid of evils and righting salubrity.

In addition stick drug and directly act on body surface point, local blood circulation and surrounding tissue nutrition can be improved, promoted Drug absorption.Drug can also be made to from superficies to interior through fur space between skin and muscles, run by the perforation of channels and collaterals, in contact internal organs, communication table, Play stronger drug action.

This clinical practice sticks acupuncture point effect explanation（By taking Dazhui acupoint as an example）：

The effect of this patch drug ingedient, which can declare, leads to the interior heat accumulate, heat-clearing and damp-drying drug, removing pattogenic heat from the blood and toxic material from the body.Dazhui acupoint（Spinous process of the seventh cervical vertebrae At lower recess）Heat in the heart is rushed down for the crossing point master of three Yang Mai of hand, three Yang Mai of foot and governor vessel, has the inducing diaphoresis that activates yang, the work got rid of evils of bringing down a fever With, for whole body bring down a fever want cave.Drug effect is enriched in this easy endosmosis, nerve endings, and acupuncture point reaction is sensitive, can be abundant Exciting human is conducted through gas, so as to promote neurohumor adjustment effect, is strengthened heat-regulating centers function, is reduced thyroid hormone With adrenergic secretion, so that heat dissipation increases, therefore Dazhui acupoint is pasted on, the power for having table expelling pathogenic factors from muscles and skin, the heat inside accumulate is by the natural fibre line of meat Reason pore breath breath reaches, and has apparent antipyretic effect, curative effect, which is substantially better than, to be sticked at the other non-acupuncture points of body.

【Embodiment 3：Pharmacological property is analyzed】

Matrine, oxymatrine are water soluble drug contained by kuh-seng, and fat-soluble poor, bioavilability is relatively low.Falsespiraea tree bark, again Name Ramulus Rubi, Mongolian name " bar reaches loud, high-pitched sound day ", is rosaceous plant sachalin raspberry leaf (Rubus Sachalinensis Leveile drying stem branch), contained flavone compound has extensive bioactivity, but its solubility property is poor, biological profit Expenditure is not high, bioactivity is not strong enough and limits its medicinal exploitation.Gardenoside polarity is larger contained by cape jasmine, nontoxic, is soluble in Water, methanol and ethyl alcohol are insoluble in the lipophylic organic solvents such as chloroform, benzene, petroleum ether, are main iridoid glycosideses in cape jasmine Compound, and one of principle active component of mast.Elecampane mainly contains terpene, flavones, volatile oil, amino acid and polysaccharide Ingredients are waited, the sesquiterpenoids using alantolactone and isoalantolactone as representative, which has, inhibits tumour cell and tuberculosis branch bar Bacterium reduces the effects that blood glucose, is the principle active component in radia heleii, such compound, which commonly uses extraction solvent, methanol and second Alcoholic solution；Kaempferia galamga also known as husky ginger, zingiber kawagoii, zingiber kawagoii, three rely, mountain is peppery etc., be Zingiber perennial herb plant, entered with rhizome Medicine, is famous Chinese medicine, and famous fragrance and food seasoning material；Kaempferia galamga has promoting the circulation of qi, middle benefit gas and analgesic effect, often For treating the diseases such as chest gastral cavity turgor, trusted subordinate's crymodynia, cold-dampness vomiting and diarrhoea, toothache, also with desinsection, inhibit the work(such as gastric ulcer and anticancer Effect；Kaempferia galamga, rich in ingredients such as volatile oil, flavones, phenolic acid and its derivatives, has extensive medicine as a kind of medical and edible dual purpose plant Reason activity and certain oxidation resistance.Fructus meliae toosendan is the dry fruit of Meliaceae plant melia toosendan, and bitter is cold in nature, slightly poisonous, has Relax liver, promoting the circulation of qi, analgesic, expelling parasite and other effects, be clinically mainly used for chest side of body, abdominal distention, colic, abdominal pain due to enterositosis etc., also with its Its compatibility of drugs is used for various diseases associated with inflammation；Data show that the ethyl acetate extract of Fructus meliae toosendan have well analgesia, Anti-inflammatory effect, but its toxicity is also larger.

It is the multilayer lipid bilayer that lipoids molecule is formed between corneocyte.The percutaneous absorbtion of drug is mainly logical The difference for the drug concentration crossed in the drug concentration and deep skin of skin surface is transported through in a manner of Passive diffusion.Drug leads to The overall process for crossing cuticula percutaneous absorbtion has：1. the drug in preparation is shifted to cuticula；2. drug is spread in cuticula；3. by Cuticula is shifted to lower-hierarchy；4. it is spread in growth epidermis and corium；5. by the capillary absorbance of upper part of dermis；6. to Body circulation shifts.The cuticula containing lipoids plays main barrier action in entire process of osmosis.Therefore, the liposoluble of drug Property more it is high it is easier penetrate skin.

Molecular size and lipophilic molecule amount are more difficult more than 600 substance to pass through cuticula.The diffusion coefficient of drug is with dividing The square root or cubic root of son amount are directly proportional, and molecular weight is bigger, and molecular volume is bigger, and diffusion coefficient is smaller.Similarly, since from TDDS to skin transhipment with assigning process, the size of distribution coefficient also influences the energy that drug enters cuticula from TDDS Power.If the medium or certain component in TDDS have very strong affinity to drug, and its Determination of oil-water partition coefficient is small, will reduce Drug enters the amount of cuticula, and then influences the transmission of drug.

With reference to above-mentioned analysis, patch of the present invention is transdermal penetration administration, for treating infantile hyperpyrexia, it is required that drug Quick acting.To achieve the above objectives, The present invention gives several preparation methods of the posts agent, such as current existing system, multi-solvent carry It takes, drug individually extraction etc..The current preparation method now made is simple and quick, and medicament effective component loss is few, can be utmostly Ground retains the action principle of prescription.It is extracted, can as much as possible extracted the various composition in medicinal material using multi-solvent, Such as water-soluble components, ester soluble constituent, are concentrated, therapeutic effect is notable using active ingredient.The method that drug individually extracts can The characteristics of further considering each medicinal material, targetedly selective extraction method, make composition in each medicinal material specifically by It extracts, further improves drug effect.It is by the Fructus meliae toosendan with certain toxicity and other medicines in above-mentioned preparation method Material extracts respectively, enters patch to avoid the unfavorable composition in Fructus meliae toosendan.

【Embodiment 4：Freezing smashing】

In the preparation method of the above-mentioned patch and the preparation method of the medicinal substances extract, it is contemplated that myrobalan, cape jasmine, river Chinaberry, elecampane, kuh-seng, falsespiraea tree bark, kaempferia galamga active ingredient in, contain substantial amounts of volatile oil, terpene, amino acid, polysaccharide etc. It is volatile, easily decompose ingredient, at normal temperatures crush can generate heat, make mentioned component destroy decompose, reduce drug effect, therefore use it is low Warm breaking method processing.

There are many mode of low-temperature grinding, but preferably with the quick-frozen effective component that could retain medicinal material to greatest extent. Conditional unit, may be employed liquid nitrogen plant, cause less than -80 DEG C of low temperature environment, by medicinal material quick freeze, then carry out powder It is broken.Can also in the presence of liquid nitrogen quick freeze, using liquid nitrogen freezers carry out Freezing smashing.Pass through recent clinical data Observation, the patch prepared using low-temperature grinding method, the more normal preparation method of therapeutic effect are significantly improved.It is specific as follows：

。

On the basis of above to the improvement of the patch preparation method, further above-mentioned medicinal material can also be carried out at broken wall Reason, especially directly by the latter made patch of medicinal material powder, after broken wall treatment, the effective ingredient of medicinal material is not easy to be destroyed, and Fully, quickly, transdermal penetration is better for release.Cell wall breaking technology, can be well exactly by breaking plant cell wall The technology of active ingredient is kept, can largely discharge plant biochemistry element.

It should be noted last that more than specific embodiment is only to illustrate the technical solution rather than limit of the invention System, although the invention is described in detail with reference to example, it will be understood by those of ordinary skill in the art that, it can be right The technical solution of the invention is modified or replaced equivalently, without departing from the spirit and model of the invention technical solution It encloses, should all cover among the right of the invention.

Claims (10)

1. a kind of mongolian medicine patch for infantile hyperpyrexia, it is characterised in that：The patch includes following component by weight：

5 parts of myrobalan,

15 parts of cape jasmine,

15 parts of Fructus meliae toosendan,

10 parts of elecampane,

20 parts of kuh-seng,

15 parts of falsespiraea tree bark,

10 parts of kaempferia galamga.

2. a kind of preparation method of mongolian medicine patch for infantile hyperpyrexia according to claim 1, it is characterised in that：

The preparation method of the patch, comprises the following steps：

Sa1：It by myrobalan, cape jasmine, Fructus meliae toosendan, elecampane, kuh-seng, falsespiraea tree bark, kaempferia galamga mixing, is crushed through pulverizer, crosses 100-200 Mesh sieve obtains medicinal powder；

Sa2：30 ~ 100 parts of medical polymer gel is added in into medicinal powder to stir evenly, and obtains ointment；

Sa3：Ointment is coated on non-woven fabrics, then covers adherent layer to get the patch product.

3. a kind of preparation method of mongolian medicine patch for infantile hyperpyrexia according to claim 2, it is characterised in that：

The Fructus meliae toosendan is replaced with water extract or ethanol extract.

4. a kind of preparation method of mongolian medicine patch for infantile hyperpyrexia according to claim 3, it is characterised in that：

The preparation method of the extract is：

Fructus meliae toosendan medicinal material is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, add 60% ethyl alcohol or distilled water, refluxing extraction 3 times, every time 1.5h, filtering, filtrate centrifugation 15min（3000 r/min）, supernatant is taken, drying in 70 DEG C of insulating boxs is put, obtains extract.

5. a kind of preparation method of mongolian medicine patch for infantile hyperpyrexia according to claim 2, it is characterised in that：

The medical polymer gel for cellulose derivative, carbomer, alginate, polyvinyl alcohol, polyvinylpyrrolidone, One or more in tragacanth, gelatin, carragheen.

6. a kind of mongolian medicine patch for infantile hyperpyrexia according to claim 1, it is characterised in that：

The extract of the medicinal material of the patch replaces, i.e.,：

With Fructus Chebulae extract replace myrobalan,

With capejasmine extract replace cape jasmine,

With Sichuan chinaberry extract replace Fructus meliae toosendan,

With Radix Inulae extract replace elecampane,

With shrubby sophora extract replace kuh-seng,

With falsespiraea tree bark extract replace falsespiraea tree bark,

Kaempferia galamga is replaced with kaempferia galamga extract.

7. a kind of preparation method of mongolian medicine patch for infantile hyperpyrexia according to claim 6, it is characterised in that：

The preparation method of the extract is as follows：

Sb1：It by myrobalan, cape jasmine, elecampane, kuh-seng, falsespiraea tree bark, kaempferia galamga mixing, crushes, crosses 20-40 mesh sieves and obtain coarse granule, respectively It is extracted using water, 50-99% ethyl alcohol, ethyl acetate as solvent, merges to obtain extracting solution I；

Sb2：Fructus meliae toosendan is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, extracted respectively using water, 50-75% ethyl alcohol as solvent, Merge to obtain extracting solution II；

Sb3：Extracting solution I, extracting solution II are merged, centrifuges, takes supernatant, dries, obtains total extract；

Sb4：By total extract powder, into medicinal powder, 30 ~ 100 parts of medical polymer gel of addition stirs evenly, and obtains ointment；

Sb5：Ointment is coated on non-woven fabrics, then covers adherent layer to get the patch product.

8. a kind of preparation method of mongolian medicine patch for infantile hyperpyrexia according to claim 6, it is characterised in that：

The preparation method of the extract is as follows：

1st, Fructus Chebulae extract

Myrobalan medicinal material 5g is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, add 60% ethyl alcohol 36-50mL, refluxing extraction 3 times, every time 1.5h, filtering, filtrate centrifugation 15min (3000 r/min) take supernatant, put drying in 70 DEG C of insulating boxs, obtain extract；

2nd, capejasmine extract

Fructus Gardeniae 15g is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, add 60% ethyl alcohol 36-50mL, refluxing extraction 3 times, every time 1.5h, filtering, filtrate centrifugation 15min (3000 r/min) take supernatant, put drying in 70 DEG C of insulating boxs, obtain extract；

3rd, Sichuan chinaberry extract

Fructus meliae toosendan medicinal material 15g is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, 60% ethyl alcohol or distilled water 36-50mL, reflux is added to carry It takes 3 times, each 1.5h, filters, filtrate centrifugation 15min (3000 r/min) takes supernatant, puts in 70 DEG C of insulating boxs and dries It is dry, obtain extract；

4th, Radix Inulae extract

Fetch earth Radix Aucklandiae medicinal material 10g, crushes, and crosses 20-40 mesh sieves and obtains coarse granule, adds 90-99% ethyl alcohol 36-50mL, refluxing extraction 3 Secondary, each 1.5h is filtered, and filtrate centrifugation 15min (3000 r/min) takes supernatant, is put drying in 70 DEG C of insulating boxs, is obtained Extract；

5th, shrubby sophora extract

Sophora flavescens 20g is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, add 60% ethyl alcohol or dilute hydrochloric acid 36-50mL, refluxing extraction 3 Secondary, each 1.5h is filtered, and filtrate centrifugation 15min (3000 r/min) takes supernatant, is put drying in 70 DEG C of insulating boxs, is obtained Extract；

6th, falsespiraea tree bark extract

Falsespiraea tree bark medicinal material 15g is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, add 95% ethyl alcohol 36-50mL, refluxing extraction 3 times, often Secondary 1.5h, filtering, filtrate centrifugation 15min (3000 r/min) take supernatant, put drying in 70 DEG C of insulating boxs, must extract Object；

7th, kaempferia galamga extract

Kaempferia galamga medicinal material 10g is taken, is crushed, 20-40 mesh sieves is crossed and obtains coarse granule, add 95% ethyl alcohol 36-50mL, refluxing extraction 3 times, every time 1.5h, filtering, filtrate centrifugation 15min (3000 r/min) take supernatant, put drying in 70 DEG C of insulating boxs, obtain extract.

9. a kind of preparation method of mongolian medicine patch for infantile hyperpyrexia according to claim 1 or 6, it is characterised in that：

The patch includes following auxiliary material by weight：Penetrating agent and/or moisturizer and/or surfactant and/or filler And/or binder；

The penetrating agent is ethyl alcohol, propylene glycol, glycerine, oleic acid, Liquid Macrogol, polyethylene glycol 400, low molecule alcohol, nitrogen One or more in ketone, urea, peppermint, camphor, borneol, eucalyptus oil, selinum oil；

The moisturizer is glycerine, the one or more in propylene glycol, sorbierite, polyethylene glycol；

The surfactant is tween；

The filler is kaolin, the one or more in zinc oxide, superfine silica gel powder, calcium carbonate, bentonite, titanium dioxide；

The binder is gelatin, the one or more in sodium carboxymethylcellulose, polyvinylpyrrolidone；

The weight ratio of the auxiliary material is：

1-10 parts of penetrating agent,

10-30 parts of moisturizer,

0.1-3 parts of surfactant,

0.5-2 parts of filler,

1-3 parts of binder.

10. a kind of mongolian medicine patch for infantile hyperpyrexia according to claim 1 to 9 any claim, feature exist In：The application method of the patch is：Drug powder is added in into gel allotment before treatment, is uniformly applied to non-woven cloth or gauze On, corresponding acupuncture point is affixed on, 40 minutes every time, is not moved back, is exchanged cards containing all personal details and become sworn brothers and use again；

The acupuncture point includes：

Water is dashed forward cave：Positioned at the neck of human body, the leading edge of nutator,

Fushe cave：4 cun under lower abdomen, Qizhong, opened by anterior median line 4 cun,

Dazhui acupoint：At spinous process of the seventh cervical vertebrae lower recess,

Quchi acupoint：Elbow arthrogryposis recess,

Nei guan point：On wrist band,

Temple：At eyebrow and tail of the eye intersection,

Yang white cave：One-inch on pupil face eyebrow.