CN100536844C - 包含酸不稳定活性成分的糊剂形式的药物制剂 - Google Patents
包含酸不稳定活性成分的糊剂形式的药物制剂 Download PDFInfo
- Publication number
- CN100536844C CN100536844C CNB018202209A CN01820220A CN100536844C CN 100536844 C CN100536844 C CN 100536844C CN B018202209 A CNB018202209 A CN B018202209A CN 01820220 A CN01820220 A CN 01820220A CN 100536844 C CN100536844 C CN 100536844C
- Authority
- CN
- China
- Prior art keywords
- preparation
- acid
- active component
- labile
- pump inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (24)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00126828 | 2000-12-07 | ||
EP00126828.3 | 2000-12-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1479611A CN1479611A (zh) | 2004-03-03 |
CN100536844C true CN100536844C (zh) | 2009-09-09 |
Family
ID=8170595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018202209A Expired - Fee Related CN100536844C (zh) | 2000-12-07 | 2001-12-05 | 包含酸不稳定活性成分的糊剂形式的药物制剂 |
Country Status (15)
Country | Link |
---|---|
US (1) | US7988999B2 (zh) |
EP (1) | EP1341524B1 (zh) |
JP (1) | JP4241041B2 (zh) |
KR (1) | KR20030059314A (zh) |
CN (1) | CN100536844C (zh) |
AT (1) | ATE529097T1 (zh) |
AU (1) | AU2002231654A1 (zh) |
BR (1) | BR0115985A (zh) |
CA (1) | CA2430816C (zh) |
CY (1) | CY1112510T1 (zh) |
DK (1) | DK1341524T3 (zh) |
ES (1) | ES2375269T3 (zh) |
PT (1) | PT1341524E (zh) |
SI (1) | SI1341524T1 (zh) |
WO (1) | WO2002045686A2 (zh) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0115989A (pt) * | 2000-12-07 | 2004-01-13 | Altana Pharma Ag | Preparação farmacêutica na forma de uma suspensão compreendendo um ingrediente ativo instável a ácido |
DE10161078A1 (de) * | 2001-12-12 | 2003-08-28 | Achim Goepferich | Matrizes zur Stabilisierung und kontrollierten Freisetzung von Problemarzneistoffen |
MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
MXPA04008070A (es) | 2003-03-10 | 2004-11-26 | Altana Pharma Ag | Novedoso proceso para la preparacion de roflumilasto. |
JP4109286B2 (ja) * | 2003-05-02 | 2008-07-02 | 順也 藤森 | 親水性ブレンドゲル |
CA2529984C (en) | 2003-06-26 | 2012-09-25 | Isa Odidi | Oral multi-functional pharmaceutical capsule preparations of proton pump inhibitors |
EP2462957B1 (en) * | 2003-09-23 | 2019-04-24 | Abyrx, Inc. | Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects |
CA2554260A1 (en) * | 2004-01-28 | 2005-08-18 | Altana Pharma Ag | Calcium, potassium, zinc, lithium and aluminium salts of pantoprazole and (s)-pantoprazole |
US8394409B2 (en) * | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
JP2006176461A (ja) * | 2004-12-24 | 2006-07-06 | Dai Ichi Seiyaku Co Ltd | 粒状物 |
JP5383183B2 (ja) * | 2005-03-16 | 2014-01-08 | タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロフルミラストを含有する矯味された剤形 |
US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
EP2007360B1 (en) * | 2006-04-03 | 2014-11-26 | Isa Odidi | Controlled release delivery device comprising an organosol coat |
CH698658B1 (de) * | 2006-04-24 | 2009-09-30 | Mepha Ag | Orale pharmazeutische Formulierung mit schneller Freisetzung für Pyridylmethylsulfinyl-Benzimidazole. |
US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
JP5318770B2 (ja) | 2006-10-10 | 2013-10-16 | ウィスコンシン アルムニ リサーチ ファンデイション | ***内乳首シーラント製剤、およびこれを用いて、熟成チーズの視覚的欠陥を抑制または除去する方法 |
CA2716399C (en) * | 2008-03-05 | 2020-07-21 | Pierre Chouvenc | Process for stabilizing an adjuvant containing vaccine composition |
BRPI1016082B1 (pt) * | 2009-04-08 | 2020-12-22 | Wisconsin Alumni Research Foundation | selante intramamário de mamilos |
EP2526931B1 (en) * | 2011-05-23 | 2014-12-17 | Deva Holding Anonim Sirketi | Wet granulation methods of cetyl myristate and/or cetyl palmitate |
FR2994390B1 (fr) | 2012-08-10 | 2014-08-15 | Adocia | Procede d'abaissement de la viscosite de solutions de proteines a concentration elevee |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
EP3496714A4 (en) | 2016-08-11 | 2020-04-22 | Adamis Pharmaceuticals Corporation | DRUG COMPOSITIONS. |
WO2019113493A1 (en) | 2017-12-08 | 2019-06-13 | Adamis Pharmaceuticals Corporation | Drug compositions |
US20220257772A1 (en) * | 2019-07-19 | 2022-08-18 | Spi Pharma, Inc. | Preparation of lipophilic active ingredients |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1122109A (zh) * | 1993-04-30 | 1996-05-08 | 阿斯特拉公司 | 含有质子泵抑制剂的兽医用组合物 |
US5708017A (en) * | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
US6207197B1 (en) * | 1997-05-24 | 2001-03-27 | West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited | Gastroretentive controlled release microspheres for improved drug delivery |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
IL75400A (en) | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
JPS6150978A (ja) | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
US4753800A (en) * | 1985-10-04 | 1988-06-28 | Warner-Lambert Company | Medicament adsorbates and their preparation |
GB2189699A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
FI90544C (fi) | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi |
US5225202A (en) * | 1991-09-30 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Enteric coated pharmaceutical compositions |
DE69229710T2 (de) * | 1991-11-15 | 2000-03-02 | Kanegafuchi Kagaku Kogyo K.K., Osaka | Esterbindung enthaltende Polymere für pharmazeutische Zubereitungen |
US5945124A (en) * | 1995-07-05 | 1999-08-31 | Byk Gulden Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole |
US6132768A (en) * | 1995-07-05 | 2000-10-17 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for reversible proton pump inhibitors |
US20010051131A1 (en) * | 1996-06-19 | 2001-12-13 | Evan C. Unger | Methods for delivering bioactive agents |
EP1019061A4 (en) * | 1997-01-29 | 2006-08-23 | Univ Johns Hopkins | UREASE-DEPENDENT ADMINISTRATION SYSTEMS FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS |
US6017950A (en) * | 1997-08-05 | 2000-01-25 | Millennium Pharmaceuticals, Inc. | Methods for controlling gram negative bacteria in mammals |
AU751066B2 (en) * | 1997-12-08 | 2002-08-08 | Nycomed Gmbh | Novel administration form comprising an acid-labile active compound |
EA004683B1 (ru) | 1999-02-23 | 2004-06-24 | Мерк Энд Ко., Инк. | Фармацевтическая композиция, содержащая омепразол |
DE60021570T2 (de) | 1999-06-07 | 2006-05-24 | Altana Pharma Ag | Neue zubereitung und darreichungsform enthaltend einen säurelabilen protonenpumpeninhibitor |
DE19925710C2 (de) | 1999-06-07 | 2002-10-10 | Byk Gulden Lomberg Chem Fab | Neue Zubereitung und Darreichungsform enthaltend einen säurelabilen Protonenpumpenhemmer |
US6787342B2 (en) * | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
CA2406864A1 (en) * | 2000-02-24 | 2001-08-30 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
US6606234B1 (en) * | 2000-09-05 | 2003-08-12 | Saint-Gobain Ceramics & Plastics, Inc. | Electrostatic chuck and method for forming an electrostatic chuck having porous regions for fluid flow |
DK1341528T3 (da) * | 2000-12-07 | 2012-03-26 | Nycomed Gmbh | Hurtigtopløsende tablet omfattende en syrelabil aktiv bestanddel |
UA80393C2 (uk) * | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
DE60130917T2 (de) * | 2000-12-21 | 2008-07-17 | Alrise Biosystems Gmbh | Induziertes phasenübergangsverfahren zur herstellung von hydrophile wirkstoffe enthaltenden mikropartikeln |
AU2006330858A1 (en) * | 2005-12-21 | 2007-07-05 | Wyeth | Protein formulations with reduced viscosity and uses thereof |
-
2001
- 2001-12-05 US US10/433,304 patent/US7988999B2/en not_active Expired - Fee Related
- 2001-12-05 ES ES01991781T patent/ES2375269T3/es not_active Expired - Lifetime
- 2001-12-05 KR KR10-2003-7007508A patent/KR20030059314A/ko not_active Application Discontinuation
- 2001-12-05 JP JP2002547472A patent/JP4241041B2/ja not_active Expired - Fee Related
- 2001-12-05 DK DK01991781.4T patent/DK1341524T3/da active
- 2001-12-05 AT AT01991781T patent/ATE529097T1/de active
- 2001-12-05 PT PT01991781T patent/PT1341524E/pt unknown
- 2001-12-05 BR BR0115985-2A patent/BR0115985A/pt not_active Application Discontinuation
- 2001-12-05 AU AU2002231654A patent/AU2002231654A1/en not_active Abandoned
- 2001-12-05 WO PCT/EP2001/014253 patent/WO2002045686A2/en not_active Application Discontinuation
- 2001-12-05 CN CNB018202209A patent/CN100536844C/zh not_active Expired - Fee Related
- 2001-12-05 SI SI200131006T patent/SI1341524T1/sl unknown
- 2001-12-05 EP EP01991781A patent/EP1341524B1/en not_active Expired - Lifetime
- 2001-12-05 CA CA2430816A patent/CA2430816C/en not_active Expired - Fee Related
-
2012
- 2012-01-05 CY CY20121100008T patent/CY1112510T1/el unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1122109A (zh) * | 1993-04-30 | 1996-05-08 | 阿斯特拉公司 | 含有质子泵抑制剂的兽医用组合物 |
US5708017A (en) * | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
US6207197B1 (en) * | 1997-05-24 | 2001-03-27 | West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited | Gastroretentive controlled release microspheres for improved drug delivery |
Also Published As
Publication number | Publication date |
---|---|
AU2002231654A1 (en) | 2002-06-18 |
SI1341524T1 (sl) | 2012-02-29 |
CN1479611A (zh) | 2004-03-03 |
WO2002045686A2 (en) | 2002-06-13 |
PT1341524E (pt) | 2011-12-30 |
DK1341524T3 (da) | 2012-01-16 |
KR20030059314A (ko) | 2003-07-07 |
ES2375269T3 (es) | 2012-02-28 |
ATE529097T1 (de) | 2011-11-15 |
CY1112510T1 (el) | 2015-12-09 |
US20040101558A1 (en) | 2004-05-27 |
US7988999B2 (en) | 2011-08-02 |
CA2430816C (en) | 2012-05-15 |
BR0115985A (pt) | 2003-12-23 |
CA2430816A1 (en) | 2002-06-13 |
WO2002045686A3 (en) | 2002-12-12 |
JP2004514733A (ja) | 2004-05-20 |
JP4241041B2 (ja) | 2009-03-18 |
EP1341524A2 (en) | 2003-09-10 |
EP1341524B1 (en) | 2011-10-19 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
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SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1060529 Country of ref document: HK |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: LANGA DIETRICH Free format text: FORMER OWNER: NICOMEDES LIMITED LIABILITY COMPANY Effective date: 20090821 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20090821 Address after: Konstanz Patentee after: Langer Dietrich Address before: Konstanz Patentee before: Nycomed GmbH |
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C17 | Cessation of patent right | ||
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Granted publication date: 20090909 Termination date: 20101205 |