CN100528232C - 包含酸不稳定活性成分的混悬液形式的药物制剂 - Google Patents
包含酸不稳定活性成分的混悬液形式的药物制剂 Download PDFInfo
- Publication number
- CN100528232C CN100528232C CNB018202217A CN01820221A CN100528232C CN 100528232 C CN100528232 C CN 100528232C CN B018202217 A CNB018202217 A CN B018202217A CN 01820221 A CN01820221 A CN 01820221A CN 100528232 C CN100528232 C CN 100528232C
- Authority
- CN
- China
- Prior art keywords
- acid
- active component
- pharmaceutical preparation
- suspension
- labile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (13)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00126829 | 2000-12-07 | ||
EP00126829.1 | 2000-12-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1541091A CN1541091A (zh) | 2004-10-27 |
CN100528232C true CN100528232C (zh) | 2009-08-19 |
Family
ID=8170596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018202217A Expired - Fee Related CN100528232C (zh) | 2000-12-07 | 2001-12-05 | 包含酸不稳定活性成分的混悬液形式的药物制剂 |
Country Status (10)
Country | Link |
---|---|
US (1) | US7357943B2 (zh) |
EP (1) | EP1341523B1 (zh) |
JP (1) | JP5009482B2 (zh) |
KR (1) | KR20030059318A (zh) |
CN (1) | CN100528232C (zh) |
AU (1) | AU2002234545A1 (zh) |
BR (1) | BR0115989A (zh) |
CA (1) | CA2430824C (zh) |
ES (1) | ES2403238T3 (zh) |
WO (1) | WO2002045692A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230270758A1 (en) * | 2017-08-25 | 2023-08-31 | L. Perrigo Company | Pharmaceutical suspensions for bismuth subsalicylates |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA80393C2 (uk) * | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
US20040005362A1 (en) * | 2002-07-03 | 2004-01-08 | Rajneesh Taneja | Liquid dosage forms of acid labile drugs |
WO2004004690A1 (en) * | 2002-07-03 | 2004-01-15 | Abbott Laboratories | Liquid dosage forms of proton pump inhibitors |
WO2004063152A2 (en) * | 2003-01-10 | 2004-07-29 | Transform Pharmaceuticals, Inc. | Lansoprazole formulations and related processes and methods |
MXPA04008070A (es) | 2003-03-10 | 2004-11-26 | Altana Pharma Ag | Novedoso proceso para la preparacion de roflumilasto. |
PE20050150A1 (es) * | 2003-05-08 | 2005-03-22 | Altana Pharma Ag | Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo |
CL2004000983A1 (es) * | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y |
JP2006528182A (ja) * | 2003-07-18 | 2006-12-14 | サンタラス インコーポレイティッド | 薬学的製剤および酸に起因する消化器疾患の治療法 |
JP5383183B2 (ja) * | 2005-03-16 | 2014-01-08 | タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ロフルミラストを含有する矯味された剤形 |
KR20140002810A (ko) * | 2005-05-05 | 2014-01-08 | 사노피-아벤티스 유.에스. 엘엘씨 | 안정한 나노입자 제형 |
US20070026071A1 (en) * | 2005-07-28 | 2007-02-01 | Qpharma, Llc | Magnesium salt proton pump inhibitor dosage forms |
EP1747776A1 (en) * | 2005-07-29 | 2007-01-31 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical composition comprising granular pantoprazole |
WO2010014231A1 (en) * | 2008-08-01 | 2010-02-04 | Cts Corporation | Rf filter/resonator with protruding tabs |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
US9833408B1 (en) * | 2016-07-28 | 2017-12-05 | Allen Greenspoon | Orally administrable formulation |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
IL75400A (en) | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
JPS6150978A (ja) | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
GB2189699A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
FI90544C (fi) | 1986-11-13 | 1994-02-25 | Eisai Co Ltd | Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi |
US4999189A (en) * | 1988-11-14 | 1991-03-12 | Schering Corporation | Sustained release oral suspensions |
YU48263B (sh) * | 1991-06-17 | 1997-09-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola |
SE9301489D0 (sv) * | 1993-04-30 | 1993-04-30 | Ab Astra | Veterinary composition |
US5708017A (en) * | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
AU751066B2 (en) * | 1997-12-08 | 2002-08-08 | Nycomed Gmbh | Novel administration form comprising an acid-labile active compound |
EA004683B1 (ru) | 1999-02-23 | 2004-06-24 | Мерк Энд Ко., Инк. | Фармацевтическая композиция, содержащая омепразол |
DE60021570T2 (de) * | 1999-06-07 | 2006-05-24 | Altana Pharma Ag | Neue zubereitung und darreichungsform enthaltend einen säurelabilen protonenpumpeninhibitor |
DE19925710C2 (de) | 1999-06-07 | 2002-10-10 | Byk Gulden Lomberg Chem Fab | Neue Zubereitung und Darreichungsform enthaltend einen säurelabilen Protonenpumpenhemmer |
US7988999B2 (en) * | 2000-12-07 | 2011-08-02 | Nycomed Gmbh | Pharmaceutical preparation in the form of a paste comprising an acid-labile active ingredient |
DK1341528T3 (da) * | 2000-12-07 | 2012-03-26 | Nycomed Gmbh | Hurtigtopløsende tablet omfattende en syrelabil aktiv bestanddel |
UA80393C2 (uk) * | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
-
2001
- 2001-12-05 BR BR0115989-5A patent/BR0115989A/pt not_active Application Discontinuation
- 2001-12-05 WO PCT/EP2001/014254 patent/WO2002045692A1/en active Application Filing
- 2001-12-05 ES ES01985365T patent/ES2403238T3/es not_active Expired - Lifetime
- 2001-12-05 JP JP2002547478A patent/JP5009482B2/ja not_active Expired - Fee Related
- 2001-12-05 AU AU2002234545A patent/AU2002234545A1/en not_active Abandoned
- 2001-12-05 CA CA2430824A patent/CA2430824C/en not_active Expired - Fee Related
- 2001-12-05 KR KR10-2003-7007556A patent/KR20030059318A/ko not_active Application Discontinuation
- 2001-12-05 CN CNB018202217A patent/CN100528232C/zh not_active Expired - Fee Related
- 2001-12-05 EP EP01985365A patent/EP1341523B1/en not_active Expired - Lifetime
- 2001-12-05 US US10/433,305 patent/US7357943B2/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20230270758A1 (en) * | 2017-08-25 | 2023-08-31 | L. Perrigo Company | Pharmaceutical suspensions for bismuth subsalicylates |
Also Published As
Publication number | Publication date |
---|---|
CN1541091A (zh) | 2004-10-27 |
US20040052832A1 (en) | 2004-03-18 |
CA2430824A1 (en) | 2002-06-13 |
EP1341523A1 (en) | 2003-09-10 |
AU2002234545A1 (en) | 2002-06-18 |
ES2403238T3 (es) | 2013-05-16 |
JP5009482B2 (ja) | 2012-08-22 |
WO2002045692A1 (en) | 2002-06-13 |
EP1341523B1 (en) | 2013-01-23 |
BR0115989A (pt) | 2004-01-13 |
US7357943B2 (en) | 2008-04-15 |
CA2430824C (en) | 2012-05-08 |
JP2004514735A (ja) | 2004-05-20 |
KR20030059318A (ko) | 2003-07-07 |
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AU751066B2 (en) | Novel administration form comprising an acid-labile active compound | |
US7785630B2 (en) | Preparation and administration form comprising an acid-labile active compound | |
CA2430829C (en) | Rapidly disintegrating tablet comprising an acid-labile active ingredient | |
CN100528232C (zh) | 包含酸不稳定活性成分的混悬液形式的药物制剂 | |
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Legal Events
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C06 | Publication | ||
PB01 | Publication | ||
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SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1068557 Country of ref document: HK |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: LANGA DIETRICH Free format text: FORMER OWNER: NICOMEDES LIMITED LIABILITY COMPANY Effective date: 20090821 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20090821 Address after: Konstanz Patentee after: Langer Dietrich Address before: Konstanz Patentee before: Nycomed GmbH |
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Granted publication date: 20090819 Termination date: 20101205 |