CN100528847C - Uv absorber compositions comprising a hydroxyphenyltriazine compound - Google Patents
Uv absorber compositions comprising a hydroxyphenyltriazine compound Download PDFInfo
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- CN100528847C CN100528847C CNB038059150A CN03805915A CN100528847C CN 100528847 C CN100528847 C CN 100528847C CN B038059150 A CNB038059150 A CN B038059150A CN 03805915 A CN03805915 A CN 03805915A CN 100528847 C CN100528847 C CN 100528847C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4966—Triazines or their condensed derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- Life Sciences & Earth Sciences (AREA)
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- Dermatology (AREA)
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- Birds (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Cosmetics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
UV absorber compositions are described, comprising (a) from 1 to 99% by weight of a hydroxyphenyltriazine compound of formula (I) wherein R1, R2 and R3 are each independently of the others C1-C18 alkyl; C2-C10 alkenyl; or phenylC1-C4 alkyl; R4 is hydrogen; or C1-C5 alkyl; and (b) from 99 to 1% by weight of a further UV absorber selected from the group of (b1) hydroxyphenyltriazines that are different from component (a), (b2) benzotriazoles, (b3) dibenzoylmethane derivatives and (b4) camphor derivatives. The compositions are suitable as UV filters in cosmetic compositions.
Description
The present invention relates to the ultraviolet absorber composition, said composition is avoided the purposes aspect the adverse effect of ultra-violet radiation at protection human body and animal skin and hair, and their purposes in cosmetics and pharmaceutical preparation.
Already known, some organic ultraviolet filtering agent such as poorly soluble triaizine compounds, has significant UV filters performance. But the solubility of this organic ultraviolet filtering agent in being suitable for the solvent of cosmetic formulations is inadequate often.
People that is to say that for the filtering agent organic against sunshine that can be incorporated at an easy rate in the cosmetic formulations having good oil-soluble organic filtering agent against sunshine exists very strong interest.
Therefore, problem of the present invention is to find organic ultraviolet filtering agent or the UV filters agent composition that has good solubility in being suitable for the solvent of cosmetic formulations.
Surprisingly, have now found that the ultraviolet absorber composition that contains selected triaizine compounds has this performance.
Therefore, the present invention relates to the ultraviolet absorber composition, it comprises:
(a) the hydroxyphenyltriazinuv compound of 1-99 % by weight following formula (1):
Wherein, R1、R
2And R3Be C independently of one another1-C
18Alkyl; C2-C
10Thiazolinyl; Or phenyl C1-C
4Alkyl;
R
4Hydrogen; Or C1-C
5Alkyl; With
(b) 99-1 wt% of another UV absorber selected from: (b1) And the component (a) the type
The hydroxyphenyl triazine, (b2) Benzotriazole, (b3) Dibenzoylmethane derivatives and (b4) Camphor
Brain derivatives.
C
1-C
18Alkyl is a straight-chain or branched-chain alkyl groups such as methyl, ethyl, n-propyl, isopropyl,
N-butyl, sec-butyl, tert-butyl, pentyl, iso-pentyl or tert-pentyl, heptyl, octyl, iso-
Octyl, nonyl, decyl, undecyl, dodecyl, tetradecyl, pentadecyl, ten
Hexadecyl, heptadecyl or octadecyl group.
C
2-C
10Alkenyl group is, for example, allyl, methallyl, isopropenyl group, a 2 - butenyl group,
3 - butenyl, isobutenyl, n-2 ,4 - diene-yl, 3 - methylbut-2 - enyl, n-oct-2 -
Enyl, n-dodecyl -2 - alkenyl or iso dodecenylsuccinic.
Phenyl-C1-C
10Alkyl group is, for example, phenylbutyl, phenylpropyl group, preferably a benzyl group or a phenethyl group.
Preferably, the composition comprises 5-95% of component (a) and 95-5% of component (b).
In the formula (1), R1、R
2And R3Preferably independently of one another C5-C
12Group.
R
1、R
2And R3Preferably have the same meaning.
Particularly preferred is an ultraviolet absorbent composition, wherein the component (a) equivalent to the following formula:
More preferably of the formula (1) wherein:
R
1And R2Is a C5-C
12Alkyl group;
R
3Is a C2-C
12Alkenyl; especially allyl; and
R
4Is hydrogen; or C1-C
5Group.
More preferably of the formula (1) compounds wherein:
R
1And R2Is a C5-C
12Alkyl group;
R
3Is phenyl; or phenyl-C1-C
4Alkyl; especially benzyl; and
R
4Is hydrogen; or C1-C
5Group.
According to the present invention, examples of the compound used is equivalent to the following formula (3), (4) and (5):
Formula (1) compounds is per se known manner prepared as described by the following: the
Formula (1c) phenyl magnesium bromide compound with the Grignard reaction of cyanuric chloride (formula (1b)) Reaction shape
Into the formula (1d) of dichloro-triazine compounds, Lewis acids, especially in the presence of aluminum chloride by
Resorcinol (formula (1e) and Friedel-Crafts acylation of resorcinol groups introduced, and according to
The group R1、R
2And R3Meaning, etherified by alkylating formula (1f) the compound adjacent to the position and
Position of the free hydroxyl, of formula (1) compounds, the process follows the following scheme:
The details can be found in Preparation Example.
Formula (1) compounds suitable as UV absorber, in particular for human use as an anti-light dose
Skin and hair.
The composition of the present invention, component (b) preferably comprises a following formula (6) UV absorber:
Wherein, L1Is a C1-C
22Alkyl, C2-C
22Alkenyl or C5-C
7Cycloalkyl group;
L
2And L6Each independently are hydrogen, hydroxy, halo, C1-C
22Alkyl or halomethyl;
L
3、L
5And L7Each independently hydrogen, hydroxy, OL1, Halo, C1-C
22Alkyl or halo
Methyl;
L
4Is hydrogen, hydroxy, OL1, Halo, C1-C
22Alkyl, phenyl or halomethyl;
L
12Is C1-C
22Alkyl, phenyl-C1-C
5Alkyl, C5-C
7Cycloalkyl group, OL1Or, preferably under
Formula (6a) a group:
And j is 1, 2 or 3.
C
2-C
22Alkenyl group is, for example, allyl, methallyl, isopropenyl group, a 2 - butenyl group,
3 - butenyl, isobutenyl, n-2 ,4 - diene-yl, 3 - methylbut-2 - enyl, n-oct-2 -
Alkenyl group, an n-dodecyl -2 - alkenyl group, an iso-dodecenyl, n-dodecyl -2 - alkenyl group or an n-octadecyl -4 - alkenyl group.
C
3-C
7Cycloalkyl group is cyclopentyl, cycloheptyl or, preferably, cyclohexyl.
Halogen is fluorine, bromine, iodine or preferably chlorine.
According to the present invention, it is particularly preferred that the formula (6) compounds, wherein:
L
1Is a C1-C
22Alkyl, C2-C
22Alkenyl or C5-C
7Cycloalkyl group;
L
2、L
3、L
5And L7Is hydrogen; and
L
4And L6As defined for formula (6).
Particularly preferably the following formula (7) of the hydroxyphenyl triazine compound:
Wherein, L1Is a C1-C
22Alkyl, C2-C
22Alkenyl or C5-C
7Cycloalkyl; and
L
9Is a C1-C
5Alkyl; or C1-C
5Alkoxy.
Particularly preferred to use the following formula (8) hydroxyphenyl triazine compound compositions of the present invention,
Component (b1):
Another preferred component (b1) Hydroxyphenyl triazine compound is equivalent to the following formula (9):
Wherein, L1Is a C1-C
22Alkyl; preferably C1-C
5Alkyl; especially methyl.
Preferably the following formula (10) a benzo triazine compound as the component (b2):
Wherein, R5Is a C1-C
12Alkyl; C1-C
5Alkoxy; C1-C
5Alkoxycarbonyl; C5-C
7Ring
Alkyl; C6-C
10An aryl group; aralkyl group;-SO3M; or the formula (10a) of a group:
R
7Is hydrogen; C1-C
5Alkyl; C1-C
5Alkyl; C...
R
8Alkyl; C...9Independently of one another are hydrogen; or C1-C
5Alkyl group;
m is 1 or 2;
n is 0 or 1;
When when m = 1, R6Is hydrogen; unsubstituted or phenyl-substituted C1-C
12Alkyl; or C6-C
10An aryl group;
时 When m = 2, R6Is a single bond; or - (CH2)
p-;
p is 1-3.
Suitable for use in the present invention, preferred component (b) is equivalent to a benzo triazine compound of the formula
(11):
Wherein, R5Is a C1-C
12Alkyl, especially C1-C
8Alkyl, in particular by the following formula (12) a compound
Matter:
Further, preferably 1 - (4 - tert-butylphenyl) -3 - (4 - methoxyphenyl) propane-1 ,3 -
Dione or butyl methoxy dibenzoyl methane as the component (b3), Or make use of camphor derivatives
Of component (b4)。
As lipophilic, therefore, the present invention is an ultraviolet absorbent composition itself or its
He soluble organic UV absorbers can be easily produced in accordance with a known method is introduced to a solution containing
Oils and fats containing cosmetic formulations, such as oil, O / W or W / O emulsion, a rod fat
Fat or gel formulations.
As lipophilic, therefore, the present invention is an ultraviolet absorbent composition itself or its
He soluble organic UV absorbers can be easily produced in accordance with a known method is introduced to a solution containing
Oils and fats containing cosmetic formulations, such as oil, O / W or W / O emulsion, a rod fat
Fat or gel formulations....
As lipophilic, therefore, the present invention is an ultraviolet absorbent composition itself or its
He soluble organic UV absorbers can be easily produced in accordance with a known method is introduced to a solution containing
Oils and fats containing cosmetic formulations, such as oil, O / W or W / O emulsion, a rod fat
Fat or gel formulations....
Any known method for the preparation of microparticles can be used to prepare both micronized UV
Absorbents, for example:
...
Any known method for the preparation of microparticles can be used to prepare both micronized UV
Absorbents, for example:
...
- Using continuous or discontinuous (batch) kneader wet kneading method (for non-pumpable paste
The high viscosity substance particle method). The wet kneading method, the solvent may be used (water or of
Cosmetic acceptable oil), grinding aids (surfactants, emulsifiers) and the polymer aids.
- By a suitable solvent, such as aqueous suspensions or suspensions containing organic solvents, or
In the water, ethanol, dichloroethane, toluene or N-methyl pyrrolidine solution of polyvinylpyrrolidone and the like true spray
Dry.
- Method according RESS (rapid expansion of supercritical solutions), which is dissolved by means of UV filters
Or a combination of filtration agent supercritical fluid (such as CO2) Of the expansion, or by the fluid dioxide
Of carbon and in a suitable organic solvent of one or more UV filters swelling with a solution
Inflation;
- By from a suitable solvent in the supercritical fluid including reprecipitation (GASR method = Gas Anti-solvent
Agent recrystallization / PCA method = use compressed antisolvent for precipitation).
As for the preparation of micronised organic UV absorber grinding equipment can be used, for example,
For example, a jet mill, ball mill, vibrating mill or hammer mill, preferably high-speed mixing mill. More
Preferably, the ball mill is a new, manufacturer of the mill for example, Netzsch (LMZ mill),
Drais (DCP-viscoflow or cosmo), Buhler AG (centrifugal mill) or
Bachhofer. Grinding is preferably carried out using grinding aids. As for the preparation of micronized organic UV
Examples of absorbent kneading apparatus, a typical batch sigma kneader hook and string
United batch kneader (IKA-Werke) or continuous kneader (Werner und
Pfleiderer produced Continua).
For all methods in the particulate grinding aid is a low molecular weight surfactant and
Emulsifiers, as text "emulsifier" and "surfactant" as those disclosed in section.
Can be used for the aqueous dispersion of the polymer aids cosmetically acceptable water-soluble polymer is
Material, for example: acrylate (Salcare types), modified or unmodified polysaccharides, polyglucosides
Or xanthan gum. Moreover, it can alkylated vinylpyrrolidone polymers, vinyl
Vinylpyrrolidone / vinyl acetate copolymer, an acyl glutamate, an alkyl polyglucoside,
ceteareth-25 or phospholipids. Oil dispersions may contain cosmetically acceptable wax-like polymer
As a matter or natural wax and processed in the processing for adjusting the viscosity of the polymer after grinding
Agent.
Useful solvents are water, saline, (poly) ethylene glycol or glycerol, it applies a water-soluble
Dispersion, and the cosmetically acceptable oils, such as the following in the "emollient" described in the chapter
Those which is suitable for oil-soluble dispersion.
The thus obtained particles of the UV absorber having an average particle size of generally 0.02 to 2 micro
M, preferably 0.05 to 1.5 microns, particularly 0.1 to 1.0 microns.
Ultraviolet absorbers can also be used in dried powder form. For this reason, the ultraviolet absorber into the
Line known grinding method, such as vacuum atomization, countercurrent spray-drying. The particle size of this powder
-2 Micron to 0.1 micron. To prevent condensation, before the pulverization method, the ultraviolet absorber
Surface-active compounds may be applied, for example coated with anionic, nonionic, or amphoteric surfactant
Surface active agents such as phospholipids or known polymers, such as PVP, acrylate.
According to the present invention, a cosmetic preparation or a pharmaceutical composition may also contain one or more such
Described in Table 1-3 of the other UV filters.
Cosmetics or pharmaceutical preparations by using conventional methods with the help of the UV absorber
Physical agents prepared by mixing, for example by simply mixing the various ingredients together the independent system
Devices, in particular through the use of already known cosmetic UV absorbers, such as octyl methoxy-
Cinnamate, salicylic acid isooctyl ester prepared by dissolving properties. UV absorbers in the
Can be used, for example, without further treatment, or in a state of fine particles used, or to
Powder form.
Cosmetic or pharmaceutical preparation containing the composition, the total weight of 0.05 to 40 wt% of a
Kinds of UV absorbers or a mixture of UV absorbers.
Preferably, the present invention of formula (1) of the UV absorber and a light-protective agent optionally another (as shown in Table 1-3
A) the mixing ratio (by weight) from 1:99 to 99:1, especially 1:95-95:1, preferably
10:90 to 90:10. Of particular interest is the mixing ratio of 20:80 to 80:20, in particular
40:60 to 60:40, preferably about 50:50. This mixture can be used to increase the solubility of particular
Or increase UV absorption.
The invention of formula (1) of the UV absorber or a combination of UV filters for the protection of the skin
Skin, hair and / or natural or artificial hair color.
Table 1 of the present invention can be additionally used with the UV absorber Suitable UV filters was
Quality
May further UV absorber of the present invention suitable for use with UV filters was
Quality is arbitrary UV-A and UV-B filtering agent substances.
Cosmetics or pharmaceutical preparations may be, for example creams, gels, liquid, alcohol and water / alcohol
, Emulsions, wax / fat compositions, stick preparations, powders or ointment. In addition to the
UV filters, the cosmetic or pharmaceutical preparations may also contain additional aids described below
Agent.
As the aqueous and oil emulsions (e.g. W / O, O / W, O / W / O and W / O / W emulsion or microemulsion
Solution), preparations containing, for example, to the total weight of the composition 0.1 to 30 wt%, preferably 0.1 to 15
Wt%, in particular 0.5 to 10 wt% of one or more ultraviolet absorber to the total composition
1 to 60 wt% by weight, in particular 5-50% by weight, preferably 10-35% by weight of at least one
Oil component to the total weight of the composition is 0-30 wt%, in particular 1-30% by weight, preferably
4-20 wt% of at least one emulsifier to the total weight of the composition 10 to 90 wt%, particularly
Do 30 to 90 weight of water, and 0-88.9% by weight, in particular 50% by weight of a further
Cosmetics acceptable additives.
The present invention is a cosmetic or pharmaceutical compositions / formulations can also contain one or one to
The additional compound as described below.
Aliphatic alcohol
In containing 6-18, preferably 8-10 carbon atoms, Guerbet alcohols based on fatty alcohols, including
Include cetyl alcohol, stearyl alcohol, cetyl / stearyl alcohol, oleyl alcohol, stearyl alcohol, C12-C
15Alcohols benzoate
Esters, acetylated lanolin alcohol, etc..
Fatty acid ester
Straight-chain C6-C
24Fatty acid and straight-chain C3-C
24Alcohols, esters of branched C6-C
13Alcohols, esters of branched C...6-C
24Alcohols, esters of branched C...6-C
24Fatty acids and branched alcohols, especially 2 - ethylhexanol, esters of hydroxy
Carboxylic acid with a straight chain or branched chain C6-C
22Fatty alcohols, in particular octyl malate, straight-chain
And / or branched fatty acids with polyhydric alcohols (for example propylene glycol, dimer diol or trimer triol) and /
Or Guerbet alcohols, for example caproic acid, caprylic acid 2 - ethylhexanoic acid, capric acid, lauric acid, iso-
Tridecanoic acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid,
Elaidic acid, petroselinic acid, linoleic acid, linolenic acid, oil, stearic acid, arachidic acid, eicosenoic -9 - ene
Acid, behenic acid and erucic acid and their mixtures process stage (for example, removal of the pressurized natural fats and oils
Obtained when the reduction by the Roelen Oxidation obtained when the formation of aldehydes, or unsaturated
And fatty acid obtained in the dimerization) with an alcohol, such as isopropanol, hexanol, octanol, 2 - ethyl-
Hexyl alcohol, decyl alcohol, lauryl alcohol, isotridecyl alcohol, myristyl alcohol, cetyl alcohol, palm oil
Alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, anti-oleyl alcohol, petroselinic alcohol, linoleic alcohol, linen alcohol,
Octadecadienoic -9 - alcohol, peanuts alcohol twenty carbon -9 - alcohol, behenyl alcohol, alcohol, vegetable scoop children Brazil
Alcohol and mixtures thereof which process stage (e.g., in the fat and oil-based ester or from a process stage
Roelen Oxidation of the aldehyde obtained in a high-pressure hydrogenation, or unsaturated fatty alcohol dimer
Process monomer fraction) of the ester.
...
Examples of such ester oils, isopropyl myristate, isopropyl palmitate, isopropyl stearate,
Ester, isopropyl isostearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate ester,
N-decyl oleate, isooctyl stearate, stearic acid isononyl isononyl isononanoate, palmitic acid
2 - ethyl hexyl laurate, 2 - hexyl ester, stearic acid 2 - hexyl decyl palmitate, 2 - octyl
Yl dodecyl oleate, oleyl ester, erucic acid oleyl ester, oleic acid ester dish scoop children, mustard
Gone child dish acid ester, cetyl octanoate / decade alcohol ester, palmitic acid, cetyl stearate, cetyl esters,
Cetyl esters of oleic acid, behenic acid, cetyl acetate, cetyl acetate, myristyl myristate
Esters, behenic acid myristyl oleate, myristyl stearate, myristyl, palmitic
Acid myristyl lactate, myristyl acrylate, di caprylic / capric acid propylene glycol ester, stearyl heptanoate
Esters of malonic acid isostearyl acrylate, octyl hydroxystearate, etc..
...
Examples of such ester oils, isopropyl myristate, isopropyl palmitate, isopropyl stearate,
Ester, isopropyl isostearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate ester,
N-decyl oleate, isooctyl stearate, stearic acid isononyl isononyl isononanoate, palmitic acid
2 - ethyl hexyl laurate, 2 - hexyl ester, stearic acid 2 - hexyl decyl palmitate, 2 - octyl
Yl dodecyl oleate, oleyl ester, erucic acid oleyl ester, oleic acid ester dish scoop children, mustard
Gone child dish acid ester, cetyl octanoate / decade alcohol ester, palmitic acid, cetyl stearate, cetyl esters,
Cetyl esters of oleic acid, behenic acid, cetyl acetate, cetyl acetate, myristyl myristate
Esters, behenic acid myristyl oleate, myristyl stearate, myristyl, palmitic
Acid myristyl lactate, myristyl acrylate, di caprylic / capric acid propylene glycol ester, stearyl heptanoate
Esters of malonic acid isostearyl acrylate, octyl hydroxystearate, etc..
...
2,6 - naphthalene dicarboxylic acid ethyl hexyl adipate, dibutyl adipate, di (2 - ethyl-
Hexyl) ester, succinic acid di (2 - ethylhexyl) ester and acetic acid isotridecyl esters, and glycols
Esters, such as ethylene glycol oil vinegar, ethylene glycol di-iso-tridecyl ester, propylene glycol di (2 - ethyl-
Caproate), propylene glycol isostearate, propylene glycol dipelargonate, butanediol diisostearate
Ester and octanoic acid ester of neopentyl glycol. C6-C
24Fatty alcohols and / or Guerbet alcohols with saturated and / or
Unsaturated aromatic carboxylic acids, in particular benzoic acids, C2-C
12Dicarboxylic acids containing 1-22 carbon atoms,
A straight-chain or branched-chain alcohols containing 2-10 carbon atoms, or 2-6 hydroxy groups and polyhydric alcohols.
Containing natural or synthetic triglycerides glycerides and derivatives
Based on the C6-C
18Fatty acids, by reacting an alcohol with other modified triglycerides 2-3
(Caprylic / capric triglyceride, wheat germ glycerides, etc.). Polymers of glycerol fatty acid ester (more
Glycero-n, such as multi-glycero-4 caprate, glyceryl -2 many isostearate, etc.
Or castor oil, hydrogenated vegetable oil, sweet almond oil, wheat germ oil, sesame oil, hydrogenated cottonseed
Oil, coconut oil, avocado oil, corn oil, hydrogenated castor oil, shea butter, cocoa butter, soybean oil,
Mink oil, sunflower oil, safflower oil, Queensland fruit oil, olive oil, hydrogenated tallow, apricot kernel oil,
Hazelnut oil, borago oil, etc.
Waxes include long-chain acids and alcohols as well as compounds having wax properties, such as carnauba
Wax, beeswax (white or yellow), lanolin wax, candelilla wax, ozokerite, Japan wax, stone
Wax, microcrystalline wax, ceresin, cetyl / stearyl alcohol ester waxes, synthetic beeswax. In addition, the pro-
Water-based wax such as cetyl / stearyl alcohol or partial glycerides.
Pearl wax:
Alkyl glycol esters, especially ethylene glycol distearate; fatty acid alkanol amides, especially
Coconut fatty acid diethanolamide; partial glycerides, especially stearic acid monoglyceride; polyvalent
Of, unsubstituted or hydroxyl-substituted carboxylic acid with 6-22 carbon atoms containing fatty alcohols
Esters, especially long-chain esters of tartaric acid; has a total of at least 24 carbon atoms, fatty substances,
For example fatty alcohols, fatty ketones, fatty aldehydes, fatty ethers and fatty carbonates, especially lauryl-one
And distearyl ether; fatty acids, such as stearic acid, hydroxystearic acid or behenic acid, containing 12-22
Carbon atoms, an olefin epoxide having 12 to 22 carbon atoms, fatty alcohols and / or having 2 -
15 carbon atoms and 2 to 10 hydroxyl groups of the ring-opening products of polyhydric alcohols, and mixtures thereof.
...
Alkyl glycol esters, especially ethylene glycol distearate; fatty acid alkanol amides, especially
Coconut fatty acid diethanolamide; partial glycerides, especially stearic acid monoglyceride; polyvalent
Of, unsubstituted or hydroxyl-substituted carboxylic acid with 6-22 carbon atoms containing fatty alcohols
Esters, especially long-chain esters of tartaric acid; has a total of at least 24 carbon atoms, fatty substances,
For example fatty alcohols, fatty ketones, fatty aldehydes, fatty ethers and fatty carbonates, especially lauryl-one
And distearyl ether; fatty acids, such as stearic acid, hydroxystearic acid or behenic acid, containing 12-22
Carbon atoms, an olefin epoxide having 12 to 22 carbon atoms, fatty alcohols and / or having 2 -
15 carbon atoms and 2 to 10 hydroxyl groups of the ring-opening products of polyhydric alcohols, and mixtures thereof.
...
Mineral oil (light or heavy), petrolatum (yellow or white), microcrystalline wax, paraffin and iso-
Paraffin compounds, hydrogenated isoparaffinic molecules such as polydecene and polybutene, hydrogenated polyisobutene,
Squalane, isohexadecyl alkanes, iso-alkanes and twelve other plants and animals from the oil sector.
Silicone or siloxane (organo-substituted polysiloxanes)
Dimethyl polysiloxanes, methylphenyl polysiloxanes, cyclic silicones, and amino -,
Fatty Acids -, alcohol -, polyether -, epoxy -, fluorine - glycosidic - and / or alkyl - modified silicone
Alkyl compound which may be liquid at room temperature, or resin form. Straight-chain polysiloxane, two
A polysiloxane (Dow Corning 200fluid, Rhodia Mirasil DM), dimethyl
Polysiloxane polyol (dimethiconol), a cyclic silicone oils, volatile silicone pentamer
(Dow Corning 345fluid), phenyl trimethyl polysiloxane (Dow Corning 556
fluid). Also suitable are dimethyl silicone oil, which is an average chain length of 200-300 dimethyl
Dimethyl siloxane units and hydrogenated silicates polysiloxane mixture. About Todd et al.
Suitable volatile silicones can additionally see the details Cosm.Toil.91,
27 (1976).
...
Dimethyl polysiloxanes, methylphenyl polysiloxanes, cyclic silicones, and amino -,
Fatty Acids -, alcohol -, polyether -, epoxy -, fluorine - glycosidic - and / or alkyl - modified silicone
Alkyl compound which may be liquid at room temperature, or resin form. Straight-chain polysiloxane, two
A polysiloxane (Dow Corning 200fluid, Rhodia Mirasil DM), dimethyl
Polysiloxane polyol (dimethiconol), a cyclic silicone oils, volatile silicone pentamer
(Dow Corning 345fluid), phenyl trimethyl polysiloxane (Dow Corning 556
fluid). Also suitable are dimethyl silicone oil, which is an average chain length of 200-300 dimethyl
Dimethyl siloxane units and hydrogenated silicates polysiloxane mixture. About Todd et al.
Suitable volatile silicones can additionally see the details Cosm.Toil.91,
27 (1976).
...
Perfluorohexane, dimethyl cyclohexane, ethyl cyclopentane, methyl isopropyl perfluorinated ether.
Emulsifier
Any conventional emulsifiers are useful in the present compositions. Emulsifier system may include, for
For example: carboxylic acids and their salts: for example lauric acid, palmitic acid, stearic acid and oleic acid as the sodium, potassium
Alkaline soaps and ammonium, metallic soap of calcium or magnesium, an organic base soap, and the like. Alkyl phosphates or phosphorus
Esters, acid phosphate, diethanolamine salts, potassium cetyl phosphate. Ethoxylated carboxylic
Acid or polyethylene glycol esters, PEG-n acylated product. Having 8-22 carbon atoms, straight chain aliphatic
Alcohol, which is 2-30 moles of ethylene oxide and / or branched 0-5 moles of propylene oxide, wherein the branched chain
With 12 to 22 carbon atoms in the alkyl group and a fatty acid having 8-15 carbon atoms
Phenol. Fatty alcohol polyglycol ethers such as laureth-n, ceteareth-n, steareth-n,
oleth-n. Fatty acid polyethylene glycol ethers, such as PEG-n stearate, PEG-n oleate,
PEG-n COCOATE. Monoglycerides and polyhydric alcohol esters. 1-30 moles of ethylene oxide with a polyhydric
Alcohol adduct C
...2-C
22Fatty acid mono-and diesters. And poly fatty acid esters, such as glycerol
Monostearate, distearate acyl-glycero-3 - diisostearate, multi-glycero-3 - two
Isostearate, tri diisobutyl glyceryl stearate, glyceryl -2 multi - sesquiisostearate ester or
Dimer were more glyceryl esters. A mixture of more of these compounds are also suitable. Fatty acid
Polyethylene glycol such as diethylene glycol monostearate, fatty acid esters and polyethylene glycol, fatty acids and
Sucrose esters such as sucro esters, glycerol and sucrose esters such as sucro glycerides. Sorbitol
Sorbitan alcohols having 6-22 carbon atoms and saturated and unsaturated fatty acids, sorbitan
Glycol mono-and di-esters and their ethylene oxide adducts. Polysorbate-n series, sorbitan alcohol
Sorbitan esters such as sorbitan sesqui-isostearate, PEG-(6) - sorbitan isostearyl alcohol
Esters, PEG-(10) - sorbitan monolaurate, sorbitan, PEG-17-sorbitan dioleyl alcohol
Acid resin. Glucose derivative, C
...8-C
22Alkyl mono-and oligosaccharides, glycosides and ethoxylated fellow
Material, preferably as glucose sugar components. O / W emulsifier, such as methyl gluceth-20 times the semi-hard
Fat acid ester, sorbitan monostearate, sorbitan / sucrose cocoate, methyl glucose sesquioleate hard
Lipid esters, cetyl / stearyl alcohol / sixteen / eighteen alkyl glucosides. W / O emulsifiers such as methyl glucose
Sugar two olein / methyl glucose isostearate. Sulfated and sulfonated derivatives, methyl butyrate
Acid alkyl ester, dioctyl succinate, alkyl lauryl sulfonate, linear sulfonated paraffin hydrocarbons,
Sulfonated tetrapropylammonium alkynyl sulfonate, sodium lauryl sulfate, sodium lauryl sulfate and sodium lauryl sulfate, ethyl
Amine, lauryl ether sulfates, lauryl ether sulfate, sodium sulfosuccinate, acetyl iso
Thiosulfate, alkanolamide sulfate, taurine esters, taurine, methyl imidazole sulfates.
Amine derivatives, amine salts, ethoxylated amines, with a chain-containing heterocycle such as alkyl amine oxides
Imidazole, pyridine derivatives, isoquinoline, cetyl pyridinium chloride, cetyl pyridinium bromide
Compounds, quaternary ammonium groups such as cetyl three bromide (CTBA), stearylalkonium. Amide
Derivatives, alkanol amides such as amide DEA, ethoxylated amides such as PEG-n amide,
Oxidation amide (oxydamide). Polysiloxane / polyalkyl / polyether copolymers and derivatives, dimethyl
Polysiloxane copolymer polyols, polysiloxane polyoxyethylene copolymers of polysiloxane diol
Copolymers. Propoxylated or POE-n ethers (Meroxapols), poloxamers or poly (oxide
Ethylene) m-block - poly (oxypropylene) n-block - poly (ethylene oxide). In the molecule with at least
A quaternary ammonium group and at least one carboxylate and / or sulfonate zwitterionic surfactants
Agent. Particularly suitable zwitterionic surfactants are the betaines, such as N-alkyl-N, N-dimethyl-
Ammonium glycinate, cocoalkyl dimethyl ammonium glycinate, N-acyl amino-propyl-N, N-dimethyl-
Ammonium glycinate, cocoyl aminopropyl - dimethyl ammonium glycinate, and two - alkyl-3 - Carboxymethyl
-3 - hydroxyethyl imidazoline (each in the alkyl or acyl group having 8-18 carbon atoms are
Sub), and cocoyl aminoethyl hydroxyethyl carboxymethyl glycinate, N-alkyl betaines, N-
Alkylamino betaines. Alkyl imidazolines, alkyl peptide (alkylo peptide), pro-
Fat acid, the self-emulsifying base and the A short textbook of KFDePolo
cosmetology, Chapter 8 ,250-251 compounds described in Table 8-7.
...
Nonionic materials, such as PEG-6 beeswax (and) PEG-6 stearate (and) Glyceryl -2 Multi -
Isostearate [Apifac], glyceryl stearate (and) PEG-100 stearate.
[Arlacel 165], PEG-5 glyceryl stearate [arlatone 983S], sorbitan
Sugar alcohols oleate (and) multi-glycero-3 ricinoleate. [Arlacel 1689], sorbitan
Sugar alcohols stearate and sucrose cocoate [arlatone 2121], glyceryl stearate and
laureth-23 [Cera-synth 945], sixteen / eighteen alcohol ceteth-20
[Cetomacrogol Wax], sixteen / Stearic alcohol and polysorbate 60 and PEG-150 and stearic
Esters -20 [Polawax GP 200, Polawax NF], sixteen / eighteen alcohol sixteen / eighteen
Alkylpolyglucoside [Emulgade PL 1618], sixteen / eighteen alcohol and ceteareth-20
[Emulgade 1000NI, Cosmowax], sixteen / eighteen alkyl glucosides and PEG-40
Castor oil [Emulgade F Special], sixteen / eighteen alcohol and PEG-40 castor oil and sixteen /
Eighteen sulfate [Emulgade F], stearyl alcohol and steareth-7 and steareth-10
[Emulgator E2155], sixteen / eighteen alcohol steareth-7 and steareth-10
[Emulsifying wax USNF], glyceryl stearate and PEG-75 stearate
[Gelot 64], propylene glycol ceteth-3 acetate [Hetester PCS], propylene glycol
isoceth-3 acetate [Hetester PHA], sixteen / eighteen alcohol ceteth-12 and
oleth-12 [Lanbritol Wax N 21], PEG-6 stearate and PEG-32 stearate
[Tefose 1500], PEG-6 stearate and ceteth-20 and steareth-20 [Tefose
2000], PEG-6 stearate and ceteth-20 and glyceryl stearate and steareth-
20 [Tefose 2561], glyceryl stearate and ceteareth-20 [Teginacid H, C,
X].
...
Nonionic materials, such as PEG-6 beeswax (and) PEG-6 stearate (and) Glyceryl -2 Multi -
Isostearate [Apifac], glyceryl stearate (and) PEG-100 stearate.
[Arlacel 165], PEG-5 glyceryl stearate [arlatone 983S], sorbitan
Sugar alcohols oleate (and) multi-glycero-3 ricinoleate. [Arlacel 1689], sorbitan
Sugar alcohols stearate and sucrose cocoate [arlatone 2121], glyceryl stearate and
laureth-23 [Cera-synth 945], sixteen / eighteen alcohol ceteth-20
[Cetomacrogol Wax], sixteen / Stearic alcohol and polysorbate 60 and PEG-150 and stearic
Esters -20 [Polawax GP 200, Polawax NF], sixteen / eighteen alcohol sixteen / eighteen
Alkylpolyglucoside [Emulgade PL 1618], sixteen / eighteen alcohol and ceteareth-20
[Emulgade 1000NI, Cosmowax], sixteen / eighteen alkyl glucosides and PEG-40
Castor oil [Emulgade F Special], sixteen / eighteen alcohol and PEG-40 castor oil and sixteen /
Eighteen sulfate [Emulgade F], stearyl alcohol and steareth-7 and steareth-10
[Emulgator E2155], sixteen / eighteen alcohol steareth-7 and steareth-10
[Emulsifying wax USNF], glyceryl stearate and PEG-75 stearate
[Gelot 64], propylene glycol ceteth-3 acetate [Hetester PCS], propylene glycol
isoceth-3 acetate [Hetester PHA], sixteen / eighteen alcohol ceteth-12 and
oleth-12 [Lanbritol Wax N 21], PEG-6 stearate and PEG-32 stearate
[Tefose 1500], PEG-6 stearate and ceteth-20 and steareth-20 [Tefose
2000], PEG-6 stearate and ceteth-20 and glyceryl stearate and steareth-
20 [Tefose 2561], glyceryl stearate and ceteareth-20 [Teginacid H, C,
X].
...
The amount of emulsifier may be, for example, the total weight of the composition is 1 to 30 wt%, particularly
Do 4-20 wt%, preferably 5-10 wt%.
When dubbed O / W emulsions, the preferred amount of this emulsifier system, the oil phase can be accounted for 5% -
20%.
Auxiliaries and additives
Cosmetic / pharmaceutical preparations, such as creams, gels, liquid, alcohol and water / alcohol solutions, emulsions,
Wax / fat compositions, stick preparations, powders or ointments, may in addition contain the following ingredients as
Auxiliaries and additives: mild surfactants, super-fat agent (Super-fatting
agent), consistency regulators, thickeners, polymers, stabilizers, biologically active ingredients, in addition to
Smelly active ingredients, anti-dandruff agents, film formers, swelling agents, further UV protection factors,
Antioxidants, hydrotropes, preservatives, insect repellents, tanning (self-tanning) agents,
Solubilizers, perfume oils, coloring agents, bacterial inhibitors.
Super Fat agent
Agents suitable for use as super fatty substances are, for example, wool wax, and lecithin, and polyethoxylated
Of the acrylated or wool wax and lecithin derivatives, polyol fatty acid esters, mono-acid
Glycerides and fatty acid alkanolamides, the latter also useful as foam stabilizers.
Surfactants
Suitable mild surfactants is particularly endurance its skin surface active agent,
Examples include fatty alcohol polyglycol ether sulfates, monoglyceride sulfates, mono-and / or or
Dialkyl sulfosuccinates, fatty isethionate esters, fatty acid sarcosinates, fatty
Acid taurides, fatty acid esters, α-olefin sulfonates, ether carboxylic acids, alkyl oligo Portuguese
Glycosides, fatty acids, glucosamine, alkyl amido betaine and / or protein fatty acid condensation products
Material, the latter preferably based on wheat proteins.
Consistency regulators / thickeners and rheology modifiers
Silica, magnesium silicate, aluminum silicate, polysaccharide or a derivative thereof, for example hyaluronic acid,
Xanthan gum, guar gum, agar, alginates, carrageenan, gellan, pectin, or change
Cellulose, such as hydroxy cellulose, hydroxypropylmethyl cellulose. Another polyacrylates or
Homopolymers of acrylic acid by the mesh and polyacrylamide, carbomer (carbopol types: 980,
981,1382, ETD 2001, ETD 2020, Ultrez 10) or Salcare categories such as
Salcare SC 80 (steareth-10 allyl ether / acrylates copolymer), Salcare SC 81
(Acrylate copolymer), Salcare SC 91 and Salcare AST (sodium acrylate copolymer
/ PPG-1 trideceth-6), Sepigel 305 (polyacrylamide / laureth-7),
Simulgel NS and Simulgel EG (hydroxyethyl acrylate / acrylic acid taurate
Sodium copolymer), Stabilen 30 (acrylate / vinyl acid isodecyl ester crosslinked polymer),
Pemulen TR-1 (acrylic acid ester / acrylic acid C
...10-30Silica, magnesium silicate, aluminum silicate, polysaccharide or a derivative thereof, for example hyaluronic acid,
Xanthan gum, guar gum, agar, alginates, carrageenan, gellan, pectin, or change
Cellulose, such as hydroxy cellulose, hydroxypropylmethyl cellulose. Another polyacrylates or
Homopolymers of acrylic acid by the mesh and polyacrylamide, carbomer (carbopol types: 980,
981,1382, ETD 2001, ETD 2020, Ultrez 10) or Salcare categories such as
Salcare SC 80 (steareth-10 allyl ether / acrylates copolymer), Salcare SC 81
(Acrylate copolymer), Salcare SC 91 and Salcare AST (sodium acrylate copolymer
/ PPG-1 trideceth-6), Sepigel 305 (polyacrylamide / laureth-7),
Simulgel NS and Simulgel EG (hydroxyethyl acrylate / acrylic acid taurate
Sodium copolymer), Stabilen 30 (acrylate / vinyl acid isodecyl ester crosslinked polymer),
Pemulen TR-1 (acrylic acid ester / acrylic acid C
...
Polymer
Suitable cationic polymers are, for example, cationic cellulose derivatives, for example, in
Trade name Polymer JR 400 from Amerchol company received quaternized hydroxymethyl cellulose,
Cationic starch, diallyl ammonium salts and copolymers of acrylamide, quaternized vinyl pyrrole
Polyvinylpyrrolidone / vinyl imidazole polymers such as Luviquat(BASF), polyethylene glycols, and condensation products of amines
Matter, quaternized collagen polypeptides, such as hydroxypropyl hydrolyzed collagen diammonium lauryl
Salt (LamequatL / Grunau), quaternized wheat polypeptides, polyethyleneimine, cationic silicone
Siloxane polymers such as methyl polysiloxane amide, adipic acid and dimethyl amino hydroxy propyl
Yl diethylenetriamine copolymer (Cartaretin / Sandoz), acrylic acid and dimethyl diallyl
Copolymers of ammonium chloride (Merquat 550/Chemviron), FR-A-2252840 as in
Polyamino described polyamide, and their crosslinked water-soluble polymers, cationic chitin derivatives,
For example, optionally in microcrystalline distribution of the quaternized form of chitosan; alkyl dihalide, such as bis
Bromide and bis dialkyl amines such as bis-dimethylamino-1 ,3 - propane condensation product, cationic
Son guar gum, for example, Celanese Corporation's Jaguar C-17, Jaguar C-16, quaternized
The ammonium salt polymers such as Miranol Company Mirapol A-15, Mirapol AD-1,
Mirapol AZ-1. As anionic, zwitterionic, amphoteric and non-ionic polymeric
Materials, can be considered for example, vinyl acetate / crotonic acid copolymers, vinyl pyrrolidone / C
Acid vinyl ester copolymer, vinyl acetate / butyl maleate / isobornyl acrylate copolymer
Substance, methyl vinyl ether / maleic anhydride copolymers and esters thereof, uncrosslinked polyacrylic acids and the more
Alcohol crosslinked polyacrylic acid, acrylamide propyl - trimethyl - ammonium chloride / acrylate copolymer,
Octyl acrylamide / methyl methacrylate / methacrylic acid tert-butyl aminoethyl methacrylate / methacrylic
Enoic acid 2 - hydroxy propyl acrylate copolymers, polyvinyl pyrrolidone, vinyl pyrrolidone / vinyl acetate
Alkenyl ester copolymers, vinyl pyrrolidone / dimethylaminoethyl methacrylate methacrylate / vinyl caprolactam
Acrylamide terpolymers and optionally derivatized cellulose ethers and silicones. In addition, the
With such EP1093796 (3-8 pages ,17-68) said polymer.
...
L / Grunau), quaternized wheat polypeptides, polyethyleneimine, cationic silicone
Siloxane polymers such as methyl polysiloxane amide, adipic acid and dimethyl amino hydroxy propyl
Yl diethylenetriamine copolymer (Cartaretin / Sandoz), acrylic acid and dimethyl diallyl
Copolymers of ammonium chloride (Merquat 550/Chemviron), FR-A-2252840 as in
Polyamino described polyamide, and their crosslinked water-soluble polymers, cationic chitin derivatives,
For example, optionally in microcrystalline distribution of the quaternized form of chitosan; alkyl dihalide, such as bis
Bromide and bis dialkyl amines such as bis-dimethylamino-1 ,3 - propane condensation product, cationic
Son guar gum, for example, Celanese Corporation's Jaguar C-17, Jaguar C-16, quaternized
The ammonium salt polymers such as Miranol Company Mirapol A-15, Mirapol AD-1,
Mirapol AZ-1. As anionic, zwitterionic, amphoteric and non-ionic polymeric
Materials, can be considered for example, vinyl acetate / crotonic acid copolymers, vinyl pyrrolidone / C
Acid vinyl ester copolymer, vinyl acetate / butyl maleate / isobornyl acrylate copolymer
Substance, methyl vinyl ether / maleic anhydride copolymers and esters thereof, uncrosslinked polyacrylic acids and the more
Alcohol crosslinked polyacrylic acid, acrylamide propyl - trimethyl - ammonium chloride / acrylate copolymer,
Octyl acrylamide / methyl methacrylate / methacrylic acid tert-butyl aminoethyl methacrylate / methacrylic
Enoic acid 2 - hydroxy propyl acrylate copolymers, polyvinyl pyrrolidone, vinyl pyrrolidone / vinyl acetate
Alkenyl ester copolymers, vinyl pyrrolidone / dimethylaminoethyl methacrylate methacrylate / vinyl caprolactam
Acrylamide terpolymers and optionally derivatized cellulose ethers and silicones. In addition, the
With such EP1093796 (3-8 pages ,17-68) said polymer.
...
Biological active ingredients may be understood as meaning, for example tocopherol, tocopherol acetate, raw
Tocopherol palmitate, ascorbic acid, deoxyribonucleic acid, retinol, bisabolol, allantoin,
Phytantriol, Panthenol, AHA acids, amino acids, ceramides, ceramide false, aromatic oil,
Plant extracts and vitamin complexes.
Deodorizing active ingredients
As a deodorant active ingredient, can be considered for example, antiperspirants such as hydrated aluminum chloride (see J.
Soc.Cosm.Chem.24, 281 (1973)). By Hoechst AG, Frankfurt (FRG)
Trademark Locrons, To what amounted to a commercially available formula Al2(OH)
5Clx2.5H
2O, chloral hydrate
Aluminum, the use of such hydrated aluminum chloride is particularly preferred (see J.Pharm.
Pharmacol., 26,531 (1975)). In addition to the hydrated chloride salt, the base can also be used
Type aluminum acetate and acidic aluminum / zirconium salts. Esterase inhibitors can be added as an additional deodorant active
Ingredients. The inhibitor is preferably a trialkyl citrate esters such as trimethyl citrate, citric acid
Three propyl, isopropyl citrate, tributyl citrate, triethyl citrate in particular
(HydagenCAT, Henkel), which inhibit enzyme activity and thus reduce odor formation.
Also be considered as esterase inhibitors are sterol sulfates substances or phosphates, such as sheep
Mao sterols, cholesterol, campesterol, sitosterol, stigmasterol alcohol sulfates or phosphates, di
Carboxylic acids and their esters, for example glutaric acid, glutaric acid monoethyl ester, glutaric acid diethyl ester, adipic acid,
Adipic acid monoethyl ester, adipic acid diethyl ester, malonic acid and diethyl malonate, and hydroxycarboxylic
Acids and their esters, such as citric acid, malic acid, tartaric acid or diethyl tartrate. Affect fine
Flora and destroy or inhibit the growth of bacterial decomposition of sweat antimicrobial active ingredient can also be saved
In that the preparation (especially rod preparation) in. Examples include chitosan, phenoxyethanol
Alcohol and chlorhexidine gluconate. Have demonstrated that 5 - chloro -2 - (2,4 - dichloro-phenoxy
Yl) - phenol (Triclosan, Irgasan, Ciba Specialty Chemicals Inc.) Is a special
Not valid.
...
O, chloral hydrate
Aluminum, the use of such hydrated aluminum chloride is particularly preferred (see J.Pharm.
Pharmacol., 26,531 (1975)). In addition to the hydrated chloride salt, the base can also be used
Type aluminum acetate and acidic aluminum / zirconium salts. Esterase inhibitors can be added as an additional deodorant active
Ingredients. The inhibitor is preferably a trialkyl citrate esters such as trimethyl citrate, citric acid
Three propyl, isopropyl citrate, tributyl citrate, triethyl citrate in particular
(HydagenCAT, Henkel), which inhibit enzyme activity and thus reduce odor formation.
Also be considered as esterase inhibitors are sterol sulfates substances or phosphates, such as sheep
Mao sterols, cholesterol, campesterol, sitosterol, stigmasterol alcohol sulfates or phosphates, di
Carboxylic acids and their esters, for example glutaric acid, glutaric acid monoethyl ester, glutaric acid diethyl ester, adipic acid,
Adipic acid monoethyl ester, adipic acid diethyl ester, malonic acid and diethyl malonate, and hydroxycarboxylic
Acids and their esters, such as citric acid, malic acid, tartaric acid or diethyl tartrate. Affect fine
Flora and destroy or inhibit the growth of bacterial decomposition of sweat antimicrobial active ingredient can also be saved
In that the preparation (especially rod preparation) in. Examples include chitosan, phenoxyethanol
Alcohol and chlorhexidine gluconate. Have demonstrated that 5 - chloro -2 - (2,4 - dichloro-phenoxy
Yl) - phenol (Triclosan, Irgasan, Ciba Specialty Chemicals Inc.) Is a special
Not valid.
...
As an anti-dandruff agent, for example, climbazole, octopirox and oxygen mercapto-pyridine
Pyridine zinc. Preferred film-forming agents include, for example, chitosan, microcrystalline chitosan,
Quaternized chitosan, polyvinylpyrrolidone, vinylpyrrolidone / vinyl acetate
Ester copolymer containing a high proportion of acrylic polymer quaternary cellulose derivatives, collagen,
Hyaluronic acid and salts thereof and similar compounds.
Antioxidants
In addition to the main light protective substances, you can also use the second type are antioxidants
Light protection substances, the substance used to interrupt when UV radiation penetrates the skin or hair, cited
From the photochemical reaction chain. Typical examples of such antioxidants are amino acids (such as glycine, group
Histidine, tyrosine, tryptophan) and derivatives thereof, imidazole (e.g., urocanic acid) and derivatives thereof,
Peptides such as D, L-carnosine, D-carnosine, L-carnosine and derivatives thereof (for example ANSERINE), carotenoids
Bu Su, carotene, lycopene and its derivatives, chlorogenic acid and derivatives thereof, lipoic acid
And its derivatives (e.g. dihydrolipoic acid), sulfur Yajin Ji glucose (aurothioglycose),
Propyl thiouracil and other thiols (for example thioredoxin, glutathione, cysteine, cystine
Acid, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, pentyl, butyl,
Lauryl, palmitoyl, oleyl, linoleyl alkenyl group, cholesteryl group, and glyceryl esters) and their
Salts, dilauryl thiodipropionate, distearyl thiodipropionate esters of thiodipropionic acid and its
Derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfo oxime compound (Example
If buthionine sulfo oxime, homocysteine pansy sulfo oxime, buthionine sulfone, five -,
VI - seven - thionine sulfo oxime), and (metal) chelating agents (e.g. hydroxy fatty acids, palmitic acid,
Phytic acid, lactose liver lipofuscin), alkyd (e.g., citric acid, lactic acid, malic acid), humic acid, bile
Juice acid, bile extracts, bilirubin, biliverdin, EDTA, EDDS, EGTA, and its derivatives
Material, unsaturated fatty acids and derivatives thereof (e.g. linolenic acid, linoleic acid, oleic acid), folic acid and
Derivatives thereof, ubiquinone and panthenol and derivatives thereof, vitamin C and derivatives thereof (e.g., ascorbic
Acid palmitate, magnesium ascorbyl phosphate, ascorbyl acetate), tocopherol and its
Derivatives (such as vitamin E acetate), vitamin A and its derivatives (such as vitamin A Palm
Ester) and benzoate of benzoin resin, pine esters rue Stand acid and derivatives thereof, glucosyl Yun
Incense glycosides, ferulic acid, Thienylidence glucitol, carnosine, butyl hydroxy toluene, butyl hydroxy
Anisole, to a dihydro nordihydroguaiaretic acid, benzophenone trihydroxybutylthio, uric acid and derivatives thereof, mannose
Sugars and their derivatives, peroxide dismutase, N-[3 - (3,5 - di-tert-butyl-4 - hydroxyphenyl) propionate
Group] sulfanilic acid (and salts thereof, such as disodium salt), zinc and derivatives thereof (e.g. ZnO, ZnSO
...4In addition to the main light protective substances, you can also use the second type are antioxidants
Light protection substances, the substance used to interrupt when UV radiation penetrates the skin or hair, cited
From the photochemical reaction chain. Typical examples of such antioxidants are amino acids (such as glycine, group
Histidine, tyrosine, tryptophan) and derivatives thereof, imidazole (e.g., urocanic acid) and derivatives thereof,
Peptides such as D, L-carnosine, D-carnosine, L-carnosine and derivatives thereof (for example ANSERINE), carotenoids
Bu Su, carotene, lycopene and its derivatives, chlorogenic acid and derivatives thereof, lipoic acid
And its derivatives (e.g. dihydrolipoic acid), sulfur Yajin Ji glucose (aurothioglycose),
Propyl thiouracil and other thiols (for example thioredoxin, glutathione, cysteine, cystine
Acid, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, pentyl, butyl,
Lauryl, palmitoyl, oleyl, linoleyl alkenyl group, cholesteryl group, and glyceryl esters) and their
Salts, dilauryl thiodipropionate, distearyl thiodipropionate esters of thiodipropionic acid and its
Derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfo oxime compound (Example
If buthionine sulfo oxime, homocysteine pansy sulfo oxime, buthionine sulfone, five -,
VI - seven - thionine sulfo oxime), and (metal) chelating agents (e.g. hydroxy fatty acids, palmitic acid,
Phytic acid, lactose liver lipofuscin), alkyd (e.g., citric acid, lactic acid, malic acid), humic acid, bile
Juice acid, bile extracts, bilirubin, biliverdin, EDTA, EDDS, EGTA, and its derivatives
Material, unsaturated fatty acids and derivatives thereof (e.g. linolenic acid, linoleic acid, oleic acid), folic acid and
Derivatives thereof, ubiquinone and panthenol and derivatives thereof, vitamin C and derivatives thereof (e.g., ascorbic
Acid palmitate, magnesium ascorbyl phosphate, ascorbyl acetate), tocopherol and its
Derivatives (such as vitamin E acetate), vitamin A and its derivatives (such as vitamin A Palm
Ester) and benzoate of benzoin resin, pine esters rue Stand acid and derivatives thereof, glucosyl Yun
Incense glycosides, ferulic acid, Thienylidence glucitol, carnosine, butyl hydroxy toluene, butyl hydroxy
Anisole, to a dihydro nordihydroguaiaretic acid, benzophenone trihydroxybutylthio, uric acid and derivatives thereof, mannose
Sugars and their derivatives, peroxide dismutase, N-[3 - (3,5 - di-tert-butyl-4 - hydroxyphenyl) propionate
Group] sulfanilic acid (and salts thereof, such as disodium salt), zinc and derivatives thereof (e.g. ZnO, ZnSO
...
Hydrotropes
To improve the flow properties, hydrotropes can also be used, such as ethoxylated or
Non-ethoxylated fewer carbon atoms, mono-ols, diols or polyols or their ethers (for example,
Such as ethanol, isopropanol, 1,2 - propylene glycol, propylene glycol, glycerin, ethylene glycol, ethylene glycol mono-
Diethyl ether, ethylene glycol monobutyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether,
Diethylene glycol monomethyl ether; diethylene glycol monoethyl ether, diethylene glycol monobutyl ether and similar products). Can test
Consider for this purpose preferably polyols having 2 to 15 carbon atoms and at least two hydroxyl groups. Multiple
Alcohol may also contain additional functional groups, especially amino groups, and / or may be modified with nitrogen. Typical
Examples are: glycerol, alkylene glycol such as ethylene glycol, diethylene glycol, propylene glycol, butylene glycol,
Hexanediol, and the average molecular weight of polyethylene glycol 100 to 1000 daltons; intrinsic degree of condensation
The process stage 1.5-10 oligo-glycerol mixture, such as a glycerol content of diethylene 40-50 wt%
The process stage a mixture of dipropylene glycerol, methyl alcohol compound, in particular such as, trimethylol
Ethane, trimethylol propane, trimethylol butane, pentaerythritol and dipentaerythritol; lower
Alkyl glycosides, especially in the alkyl group having 1-8 carbon atoms, a lower alkyl glycoside, such as methyl
And butyl glucoside; having 5-12 carbon atoms, sugar alcohols such as sorbitol or mannitol
Alcohol; having 5-12 carbon atoms, sugars such as glucose or sucrose; amino sugars, such as Portuguese
Glycosaminoglycan; glycol amines, such as diethanolamine or 2, - amino-1 ,3 - propanediol.
...
To improve the flow properties, hydrotropes can also be used, such as ethoxylated or
Non-ethoxylated fewer carbon atoms, mono-ols, diols or polyols or their ethers (for example,
Such as ethanol, isopropanol, 1,2 - propylene glycol, propylene glycol, glycerin, ethylene glycol, ethylene glycol mono-
Diethyl ether, ethylene glycol monobutyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, propylene glycol monobutyl ether,
Diethylene glycol monomethyl ether; diethylene glycol monoethyl ether, diethylene glycol monobutyl ether and similar products). Can test
Consider for this purpose preferably polyols having 2 to 15 carbon atoms and at least two hydroxyl groups. Multiple
Alcohol may also contain additional functional groups, especially amino groups, and / or may be modified with nitrogen. Typical
Examples are: glycerol, alkylene glycol such as ethylene glycol, diethylene glycol, propylene glycol, butylene glycol,
Hexanediol, and the average molecular weight of polyethylene glycol 100 to 1000 daltons; intrinsic degree of condensation
The process stage 1.5-10 oligo-glycerol mixture, such as a glycerol content of diethylene 40-50 wt%
The process stage a mixture of dipropylene glycerol, methyl alcohol compound, in particular such as, trimethylol
Ethane, trimethylol propane, trimethylol butane, pentaerythritol and dipentaerythritol; lower
Alkyl glycosides, especially in the alkyl group having 1-8 carbon atoms, a lower alkyl glycoside, such as methyl
And butyl glucoside; having 5-12 carbon atoms, sugar alcohols such as sorbitol or mannitol
Alcohol; having 5-12 carbon atoms, sugars such as glucose or sucrose; amino sugars, such as Portuguese
Glycosaminoglycan; glycol amines, such as diethanolamine or 2, - amino-1 ,3 - propanediol.
...
Suitable preservatives include, for example, methyl paraben -, ethyl -, propyl -,
Butyl -, benzyl alcohol chloride 2 - bromo-2 - nitropropane-1 ,3 - diol, dehydroacetic acid, ammonium weight
Alkyl urea 2 - dichloro - benzyl alcohol, DMDM hydantoin, formaldehyde solution, methyl dibromo glutaronitrile,
Phenoxyethanol, sodium hydroxymethyl glycinate, imidazolidinyl urea, triclosan, and the references are
Another kind of substance listed in: KFDe Polo-A short extbook of
cosmetology, Chapter 7, page 210-219 page Table 7-2,7-3,7-4 and 7-5.
Bacterial inhibitor
Typical examples of bacterial inhibitors for Gram-positive bacteria corrosion effects
Agents, such as 2,4,4 '- trichloro-2'-hydroxydiphenyl ether, chlorhexidine (1,6 - bis (4 -
Chlorophenyl - biguanide) hexane) or TCC (3,4,4 '- trichloro-N-carbanilide). Large amounts of aromatic
Ether compounds and oil also has antibacterial properties. A typical example is the clove oil, peppermint oil and musk
The active ingredient in vanilla oil eugenol, menthol and thymol. Of interest in the natural
Deodorant is terpene alcohol farnesol (3,7,11 - trimethyl-2 ,6,10 - cyclododecatriene -1 -
Alcohol), which exists in the linden tree flower oil. Glycerol monolaurate has also been proven to be a bacteriostatic agent.
Additional bacterial inhibitor formulations present in an amount of usually 0.1 to 2 solids content wt%.
...
Typical examples of bacterial inhibitors for Gram-positive bacteria corrosion effects
Agents, such as 2,4,4 '- trichloro-2'-hydroxydiphenyl ether, chlorhexidine (1,6 - bis (4 -
Chlorophenyl - biguanide) hexane) or TCC (3,4,4 '- trichloro-N-carbanilide). Large amounts of aromatic
Ether compounds and oil also has antibacterial properties. A typical example is the clove oil, peppermint oil and musk
The active ingredient in vanilla oil eugenol, menthol and thymol. Of interest in the natural
Deodorant is terpene alcohol farnesol (3,7,11 - trimethyl-2 ,6,10 - cyclododecatriene -1 -
Alcohol), which exists in the linden tree flower oil. Glycerol monolaurate has also been proven to be a bacteriostatic agent.
Additional bacterial inhibitor formulations present in an amount of usually 0.1 to 2 solids content wt%.
...
Natural and / or artificial mixtures of aromatic compounds may be mentioned as perfume
Oil. Natural aromatic compounds are, for example, extracts of flowers (lily, lavender, rose,
Jasmine, neroli, ylang ylang tree), stem and leaf extract (geranium, patchouli, small grains), fruit
Real extract (anise, coriander, carraway, juniper), fruit peel extract (bergamot, lemon
Lemon, orange), root extract (nutmeg, angelica, celery, cardamom, costus, Iris,
Kaermushen), wood extract (pinewood, sandalwood, guaiac wood, cedar, rosewood), grass
Drugs and plant extracts (tarragon, lemon grass, sage, thyme), needles and twigs extract (cloud
Fir, pine, Scots pine, alpine Dacrydium), resins and balsam extract (Persian resins,
Elemi, benzoin, myrrh resin, mastic, opoponax). Animals can also be considered the original
Materials, such as civet and castoreum. Typical synthetic aromatic compounds are, for example, esters,
Ether, aldehyde, ketone, alcohol or a hydrocarbon-based product. Aromatic ester type compounds are, for example, benzyl acetate
Acrylate, phenoxyethyl isobutyrate, ethyl acetate, tert-butyl cyclohexyl acetate, linalyl ester, ethyl
Acid methyl ester benzyl alcohol, phenyl ethyl acetate, linalyl benzoate, benzyl formate, Gan
Acid, ethyl methyl phenyl propionate, allyl cyclohexyl propionate, methyl phenyl orthoester
(Styrallyl propionate) and benzyl salicylate. Ethers include, for example, benzyl ethyl ether;
Aldehydes include, for example, a hydrocarbon having from 8 to 18 atoms, straight-chain n-aldehyde, citral, citronellal, fragrant
Mao group acetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilial and bourgeonal; ketones include,
For example, ionone, isobutyl methyl ionone ketone and methyl alcohol cedar; alcohols include, for example, fennel
, Citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol,
Oil; hydrocarbons include terpenes and balms. Preferably, however, use of gas together to produce attractive
Various aromatic flavor compound. Mainly for relatively volatile aroma components
Ethers of low oil are also suitable as perfume oils, e.g. sage oil, camomile oil white, lilac
Oil, bee flower oil, cinnamon leaf oil, linden blossom oil, barbed asphalt, vetiver oil, frankincense oil, white pine
Sesame oil, labolanum oil and lavandin oil. Preferable to use bergamot oil, dihydromyrcenol,
Lilial, lyral, citronellol, phenylethyl alcohol, hexyl cinnamic aldehyde, geraniol, benzyl acetone,
Cyclamen aldehyde, linalool, boisambrene forte, ambroxan, indole, hedione,
sandelice, lemon oil, tangerine oil, orange oil, allyl amyl glycolate,
cyclovertal, lavandin oil, nutmeg sage oil, damascone, bourbon geranium
Oil, salicylic acid cyclohexyl ester, vertofix coeur, iso-E-Super, Fixolide NP,
evernyl, r-iraldein, phenyl acetic acid, geranyl acetate, benzyl acetate, rose oxide
Compounds, romillat, irotyl and floramat, which either alone, or another
Mixture.
...
Natural and / or artificial mixtures of aromatic compounds may be mentioned as perfume
Oil. Natural aromatic compounds are, for example, extracts of flowers (lily, lavender, rose,
Jasmine, neroli, ylang ylang tree), stem and leaf extract (geranium, patchouli, small grains), fruit
Real extract (anise, coriander, carraway, juniper), fruit peel extract (bergamot, lemon
Lemon, orange), root extract (nutmeg, angelica, celery, cardamom, costus, Iris,
Kaermushen), wood extract (pinewood, sandalwood, guaiac wood, cedar, rosewood), grass
Drugs and plant extracts (tarragon, lemon grass, sage, thyme), needles and twigs extract (cloud
Fir, pine, Scots pine, alpine Dacrydium), resins and balsam extract (Persian resins,
Elemi, benzoin, myrrh resin, mastic, opoponax). Animals can also be considered the original
Materials, such as civet and castoreum. Typical synthetic aromatic compounds are, for example, esters,
Ether, aldehyde, ketone, alcohol or a hydrocarbon-based product. Aromatic ester type compounds are, for example, benzyl acetate
Acrylate, phenoxyethyl isobutyrate, ethyl acetate, tert-butyl cyclohexyl acetate, linalyl ester, ethyl
Acid methyl ester benzyl alcohol, phenyl ethyl acetate, linalyl benzoate, benzyl formate, Gan
Acid, ethyl methyl phenyl propionate, allyl cyclohexyl propionate, methyl phenyl orthoester
(Styrallyl propionate) and benzyl salicylate. Ethers include, for example, benzyl ethyl ether;
Aldehydes include, for example, a hydrocarbon having from 8 to 18 atoms, straight-chain n-aldehyde, citral, citronellal, fragrant
Mao group acetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilial and bourgeonal; ketones include,
For example, ionone, isobutyl methyl ionone ketone and methyl alcohol cedar; alcohols include, for example, fennel
, Citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terpineol,
Oil; hydrocarbons include terpenes and balms. Preferably, however, use of gas together to produce attractive
Various aromatic flavor compound. Mainly for relatively volatile aroma components
Ethers of low oil are also suitable as perfume oils, e.g. sage oil, camomile oil white, lilac
Oil, bee flower oil, cinnamon leaf oil, linden blossom oil, barbed asphalt, vetiver oil, frankincense oil, white pine
Sesame oil, labolanum oil and lavandin oil. Preferable to use bergamot oil, dihydromyrcenol,
Lilial, lyral, citronellol, phenylethyl alcohol, hexyl cinnamic aldehyde, geraniol, benzyl acetone,
Cyclamen aldehyde, linalool, boisambrene forte, ambroxan, indole, hedione,
sandelice, lemon oil, tangerine oil, orange oil, allyl amyl glycolate,
cyclovertal, lavandin oil, nutmeg sage oil, damascone, bourbon geranium
Oil, salicylic acid cyclohexyl ester, vertofix coeur, iso-E-Super, Fixolide NP,
evernyl, r-iraldein, phenyl acetic acid, geranyl acetate, benzyl acetate, rose oxide
Compounds, romillat, irotyl and floramat, which either alone, or another
Mixture.
...
Suitable and approved for cosmetic purposes substances may be used as the colorant, as in the following publications
In the compilation of those substances, "Kosmetische Farbemittel",
Farbstoffkommission der Deutschen Forschungsgemeinschaft,
Verlag Chemie, Weinheim ,1984,81-106 pages. Typical use concentration of colorants
Degree of interest based on the total mixture of 0.001 to 0.1 wt%.
Other additives
In addition, the cosmetic formulations, it may also contain the following additives: anti-foam agent, such as
Polysiloxane; structuring agent (structurant), such as maleic acid; solubilizing agents, such as ethylene
Alcohol, propylene glycol, glycerol or diethylene glycol; opacifiers, such as latex, styrene / PVP or
Styrene / acrylamide copolymers; complexing agents, such as EDTA, NTA, alaninediacetic acid or
By acid; propellants such as propane / butane mixtures, N2O, dimethyl ether, CO2、N
2Or
Air; an oxidation dye precursor and the developer-called coupler component; reductant ratio
Such as thioglycolic acid and derivatives thereof, thiolactic acid, cysteamine, thiomalic acid or thioglycolic
Alkyl sulfonic acids; or oxidant such as hydrogen peroxide, potassium bromate or sodium bromate.
Suitable repellents are, for example, N, N-diethyl - a - toluamide, 1,2 - pentanediol
3535, or pesticides; suitable tanning agents are, for example, dihydroxyacetone and / or erythrulose or
By hydroxy acetone and / or as described in WO01/85124 dihydroxyacetone precursor and / or erythrulose
Sugar.
As SPF Boosters polymer beads or hollow sphere
The above UV absorbers and UV absorber combination with SPF enhancers, such as styrene
/ Acrylic ester copolymer, silica beads, spherical magnesium silicate, crosslinked polymethacrylate
Methyl ester (PMMA; Micopearl M305 Seppic) non-active ingredients can be combined
UV sun protection products to achieve the best performance. Holosphere additives (SunspheresISP, Silica Shells Kobo.) Can deviate radiation, thereby increasing the light quanta
The effective optical path length (EP0893119). Some beads, such as those mentioned previously, the expansion
Process to provide a soft feel. Moreover, this bead, such as optical rotation MicropearlM305
Resistance can be adjusted by eliminating reflections and shiny skin and indirect scattering UV light.
When formulated as O / W emulsions, the preferred amount of such SPF enhancers should be accounted for 1% of total emulsion -
10%.
Cosmetics or pharmaceutical preparations
Cosmetic or pharmaceutical formulation comprising in a variety of cosmetic preparations. In particular, can
Consider, for example, the following formulation:
- Skin care formulations, such as flaky or liquid soap, soap or detergent washing paste
Substance in the form of skin washing and cleaning preparations,
- Bath products, such as liquid (bubble bath, creams, shower preparations) or solid bath
Products, such as bath salts and block;
- Skin care preparations, such as skin emulsions, multiple emulsions or skin oils;
- Cosmetic personal care preparations, such was cream or powder creams, face powder (sparse
Loose or pressed) in the form of facial cosmetics, rouge or cream-style cosmetics, eye care system
Agents such as eye shadow preparations, mascara, eyeliner, eye cream or cream solid; lips care system
Agents, such as lipstick, lip balm, lip liner; nail care preparations, such as nail polish, nail
Oil remover, nail hardeners or cuticle removers;
- Foot care preparations, such as feet products, foot powder, foot by foot cream or balm, special
Deodorants and antiperspirants or callus removers;
- Light-protective agents, such as suntan lotion, sunscreen water, sunscreen or oil, sunscreen or
By local supplies, pre-brown (pre-tanning) agent or after-sun products;
- Skin tanning preparations, such as tanning cream;
- Bleaching preparations, e.g. for skin bleaching or shiny skin preparations;
- Insect repellent, such as deworming oil, water repellent, insect repellent sprays or sticks;
- Deodorants, such as deodorant sprays, pump sprays, deodorant gels, sticks or roll
Cleaners deodorant;
- Antiperspirants, eg antiperspirant sticks, creams or roll-on antiperspirant;
- For cleaning and care of a defective skin formulations, such as synthetic detergents (solid or
Liquid), peeled or scrub preparations or peeling film;
- Preparation of chemicals in the form of hair (hair removal method), such as hair powder, liquid removal system
Agents, hair removal cream or paste formulation, gel or aerosol foam formulations in the form of hair removal;
- Shaving preparations, such as shaving soap, shaving foam, no foam shaving creams, foams and gels
Agents for pre-drying shave shaving preparations, shaving or after-shave lotion, after supplies;
- Spice preparations, such as perfume (cologne, eau de toilette, eau de
parfum, parfum de toilette, perfume), perfume oils or fragrances cream;
- Cosmetic hair treatment formulations, such as shampoos and conditioners were in the form of shampoo,
Hair care products, such as pre-treatment preparations, hair nutritional supplements, styling creams, styling
Gels, balms, shampoos, processing package, fine hair care products, hair structure preparations,
Eg for permanent perm perm agent (blanching, warm hot, cold foil), hair straightening, liquid
Hair styling agents, hair foams, hair sprays, bleaching agents such as hydrogen peroxide solution,
Shiny shampoos, bleaching creams, bleaching, bleaching pastes or oils, temporary, semi-permanent
Persistent, or permanent hair dyes, including natural hair from the oxidation dye or colorant,
Such as henna or white flowers spring yellow chrysanthemums dye formulations.
...
- Cosmetic hair treatment formulations, such as shampoos and conditioners were in the form of shampoo,
Hair care products, such as pre-treatment preparations, hair nutritional supplements, styling creams, styling
Gels, balms, shampoos, processing package, fine hair care products, hair structure preparations,
Eg for permanent perm perm agent (blanching, warm hot, cold foil), hair straightening, liquid
Hair styling agents, hair foams, hair sprays, bleaching agents such as hydrogen peroxide solution,
Shiny shampoos, bleaching creams, bleaching, bleaching pastes or oils, temporary, semi-permanent
Persistent, or permanent hair dyes, including natural hair from the oxidation dye or colorant,
Such as henna or white flowers spring yellow chrysanthemums dye formulations.
...
The final formulations listed may exist in a variety of form, such as:
The final formulations listed may exist in a variety of form, such as:...
The final formulations listed may exist in a variety of form, such as:...
- An oil, cream, milk or liquid form,
- Powder, lacquer, tablet or cosmetic form,
- Rod,
- Sprays (using propellant gas sprays or pump-type spray) or aerosol
Form,
- Foam, or
- Paste.
As a cosmetic preparation for skin, which is particularly important that the light protection formulations, compared
Such as suntan lotion, water, sunscreen, sunscreen, sunscreen, sunscreen or partial pre-made brown
Agent or sun supplies, as well as skin tanning preparations, such as tanning cream. Of particular interest
Is sunscreen, sunscreen water, sunscreen lotions and sprays in the form of sunscreen formulations presented.
As for hair cosmetic formulations, particularly important that the system described above for hair treatment
Agents, particularly showed shampoo, hair conditioner in the form of shampoo, hair care products, for example,
Such as pretreatment preparations, hair nutritional supplements, styling creams, styling gels, balms, shampoos,
Processing package, fine hair treatment agents, hair straightening, liquid hair fixatives, hair foams
And hair sprays. Of particular interest are present in the form of shampoo shampoo.
Shampoo has, for example the following composition 0.01 to 5 wt% of ultraviolet absorbent according to the present invention,
Agent, 12.0 wt% of laureth-2-sulfate, 4.0% by weight of cocamidopropyl beet
Base, 3.0% by weight of sodium chloride, and water to 100%.
For example, in particular the hair cosmetic preparation can use the following:
a1) a UV absorber of the present invention, PEG-6-C10Oxygen alcohol and sorbitan sesquioleate alcohol
Esters composed of self-emulsifying preparation of raw materials, to which water and any desired quaternary ammonium compound
Materials, such as 4% of the mink amido propyl-2 - hydroxyethyl ammonium chloride or Quaternium 80;
a2) a UV absorber of the present invention, tributyl citrate and PEG-20-sorbitan
Monooleate preparation of raw materials consisting of spontaneous emulsification, to which water and any desired quaternary
Ammonium compounds, such as 4% of the mink amidopropyl dimethyl-2 - hydroxyethyl ammonium chloride or
Quaternium 80;
b) an ultraviolet absorber in the present invention, triethylene glycol butyl and tributyl citrate in the quat-
Doping solution;
c) a UV absorber of the present invention with N-alkyl pyrrolidone, or a mixture solution.
In such formulations, of other typical ingredients are preservatives, fungicides and bacterial static agent,
Fragrances, dyes, pigments, thickeners, wetting agents, humectants, fats, oils, waxes or
Cosmetics and personal care products and other typical ingredients, such as alcohols, polyols, polymers,
Electrolytes, organic solvents, silicone derivatives, emollients, emulsifiers or emulsifying surfactants,
Surface active agents, dispersants, antioxidants, anti-irritant and anti-inflammatory agents.
Examples of cosmetic and pharmaceutical preparations (X = preferred combination)
O / W systems:
Ingredient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
Emulsifier | ||||||||
Cetyl phosphate, potassium phosphate, 2% -5% | × | |||||||
Sixteen / stearyl alcohol / dicetyl phosphate ester / Cetech-10 phosphate, 2% -6% | × | |||||||
Anthranilic acid stearyl sodium formyl, 1% -2% | × | |||||||
Anthranilic acid stearyl sodium formyl, 1% -2%... | × | |||||||
Quaternium-32 1%-5% | × | |||||||
Anthranilic acid stearyl sodium formyl, 1% -2%... | × | |||||||
Steareth-2/Steareth-21 2%-5% | × | |||||||
Polyglyceryl-methyl glucose distearate, 1% -4% | × | |||||||
Lipophilic emollient / oil dispersion, 15% -20% | × | × | × | × | × | × | × | × |
Fatty alcohols and / or waxes, 1% -5% | × | × | × | × | × | × | × | × |
Thickeners (water-swellable thickeners) 0.5% -1.5% | × | × | × | × | × | × | × | × |
Preservatives, 0.5% -1% | × | × | × | × | × | × | × | × |
Chelating agents (eg EDTA), 0% -0.2% | × | × | × | × | × | × | × | × |
Antioxidants, 0.05% -0.2% | × | × | × | × | × | × | × | × |
Deionized water, amount, 100% | × | × | × | × | × | × | × | × |
Perfume oil, 0.1% -0.4% | × | × | × | × | × | × | × | × |
Ultraviolet absorber of the present invention, 1% -20% | × | × | × | × | × | × | × | × |
Table 1-3 The ultraviolet absorber, 0% -30% | × | × | × | × | × | × | × | × |
W / O system
Ingredient | 1 | 2 | 3 | 4 | 5 |
Emulsifier | |||||
Polyglyceryl-2 stearate two more hydroxyl groups: 2% -4% | × | ||||
More than two hydroxy PEG-30 stearate, 2% -4% | × | ||||
Sorbitan esters of rapeseed oil, 1% to 5% | × | ||||
PEG-45 / dodecyl glycol copolymer, 1% to 5% | × | ||||
Sorbitan oleate / Polycerol-3 ricinoleate 1% -5% | × | ||||
Lipophilic emollient / oil dispersion, 10% -20% | × | × | × | × | |
Fatty alcohols and / or a wax, 10% -15% | × | × | × | × | |
Electrolyte (NaCl, MgSO4),0.5%-1% | × | × | × | × | |
Polyol phase (propylene glycol, glycerine), 1% -8% | × | × | × | × | |
Preservatives, 0.3% -0.8% | × | × | × | × | |
Perfume oil, 0.1% -0.4% | × | × | × | × | |
Chelating agents (eg EDTA), 0% -0.2% | × | × | × | × | |
Antioxidants, 0.05% -0.2% | × | × | × | × | |
Deionized water, amount, 100% | × | × | × | × | |
Ultraviolet absorber of the present invention, 1% -20% | × | × | × | × | |
Table 1-3 The ultraviolet absorber, 0% -30% | × | × | × | × |
W / polysiloxane system
Ingredient | 1 | 2 | 3 | 4 |
Emulsifier | ||||
Dimethyl polysiloxane copolymer polyol / cyclomethicone, 5% -10% | × | × | ||
Lauryl dimethicone copolyol, 5% -10% | × | × | ||
Polysiloxane phase | ||||
Cyclopenta polysiloxane, 15% -25% | × | × | ||
Dimethyl polysiloxane, 15% -25% | × | × | ||
Silicone elastomer | ||||
Dimethicone / vinyl dimethicone cross-linked copolymer, 1% -10% | × | × | × | × |
Humectant / polyols (propylene glycol, glycerin), 2% to 8% | × | × | × | × |
Chelating agents (eg EDTA), 0% -0.2% | × | × | × | × |
Antioxidants, 0.05% -0.2% | × | × | × | × |
Preservatives, 0.3% -0.8% | × | × | × | × |
Perfume oil, 0.1% -0.4% | × | × | × | × |
Deionized water, amount, 100% | × | × | × | × |
Ultraviolet absorber of the present invention, 1% -20% | × | × | × | × |
Table 1-3 The ultraviolet absorber, 0% -30% | × | × | × | × |
Multiple emulsion
Ingredient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 |
Primary emulsion W1 / O | ||||||||||||
More than two hydroxy PEG-30 stearate, 2% -6% | × | × | × | |||||||||
Cetyl dimethicone copolyol, 1% -3% | × | × | ||||||||||
More than two PEG-30 hydroxystearate / Steareth-2/Steareth-21 4% -6% | × | × | ||||||||||
Polyglyceryl-2 stearate two more hydroxyl groups, 1% -3% | × | × | ||||||||||
Polyglyceryl-6 ricinoleate, 1% -3% | × | × | × | |||||||||
Oil phase, 15% -30% | ||||||||||||
Fatty acid ester | × | × | × | × | × | × | × | |||||
Natural and synthetic triglycerides | × | × | × | × | × | × | × | |||||
A hydrocarbon oil | × | × | × | × | × | × | × | |||||
Silicone | × | × | × | × | × | × | × | |||||
Preservatives, 0.3% -0.8% | × | × | × | × | × | × | × | × | × | × | × | × |
Deionized water, amount, 100% | × | × | × | × | × | × | × | × | × | × | × | × |
Monofunctional ionic O / W emulsifier | ||||||||||||
Sorbitan monostearate, sorbitan / Sucrose cocoate, 3% -7% | × | × | × | |||||||||
Sucrose laurate, 3% -7% | × | × | × | |||||||||
Poloxamer 407,3% -7% | × | × | × | |||||||||
Polyoxyethylene (20) polysorbate monooleate, 3% -5% | × | × | × | |||||||||
Primary emulsion W1 / O, 50% | × | × | × | × | × | × | × | × | × | × | × | × |
Thickeners (water-swellable polymers), 0.3% -1% | × | × | × | × | × | × | × | × | × | × | × | × |
Deionized water, amount, 100% | × | × | × | × | × | × | × | × | × | × | × | × |
Perfume oil, 0.1% -0.4% | × | × | × | × | × | × | × | × | × | × | × | × |
Ultraviolet absorber of the present invention, 1% -20% | × | × | × | × | × | × | × | × | × | × | × | × |
Table 1-3 The ultraviolet absorber, 0% -30% | × | × | × | × | × | × | × | × | × | × | × | × |
O1/W/O2 emulsion
Ingredient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
Primary emulsion O1 / W | ||||||||
PEG-60 hydrogenated castor oil, 25% | × | × | × | × | ||||
Steareth-25,25% | × | × | × | × | ||||
Oil phase, 75% | ||||||||
Fatty acid ester | × | × | ||||||
Natural and synthetic triglycerides | × | × |
Ingredient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
A hydrocarbon oil | × | × | ||||||
Silicone | × | × | ||||||
Preservatives, 0.3% -0.8% | × | × | × | × | × | × | × | × |
Deionized water, amount, 100% | × | × | × | × | × | × | × | × |
Polyfunctional nonionic W / O emulsifier, 2% -5% | × | × | × | × | × | × | × | × |
Wax, 1% to 5% | × | × | × | × | × | × | × | × |
The oil phase, 20% -30% | × | × | × | × | × | × | × | × |
Fatty acid ester | ||||||||
Natural and synthetic triglycerides | ||||||||
A hydrocarbon oil | ||||||||
Silicone | ||||||||
Primary emulsion O1 / W, 15% | × | × | × | × | × | × | × | × |
Electrolyte (NaCl, MgSO4),0.1%-0.5% | × | × | × | × | × | × | × | × |
Deionized water, amount, 100% | × | × | × | × | × | × | × | × |
Perfume oil, 0.1% -0.4% | × | × | × | × | × | × | × | × |
Ultraviolet absorber of the present invention, 1% -20% | × | × | × | × | × | × | × | × |
Table 1-3 The ultraviolet absorber, 0% -30% | × | × | × | × | × | × | × | × |
Microemulsion
Ingredient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
Surfactants | ||||||||||
PEG-8 caprylic / capric glycerides, 10% -25% | × | × | × | × | × | |||||
PPG-5-ceteth-20 10%-25% | × | × | × | × | × | |||||
Cosurfactant | ||||||||||
Polyglyceryl-6 isostearate, 5% -15% | × | × | ||||||||
Polyglyceryl-3 Diisostearate 5% -15% | × | × | ||||||||
Polyglyceryl-6 dioleate, 5% -15% | × | × | ||||||||
PPG-10 cetyl ether, 5% -15% | × | × | ||||||||
Ethoxy-diethylene glycol, 5% -15% | × | × | ||||||||
Oil phase, 10% -80% | × | × | × | × | × | × | × | × | × | × |
Isostearyl benzoate | ||||||||||
Isostearyl isostearate | ||||||||||
PEG-7 glyceryl cocoate | ||||||||||
Ring methyl polysiloxane | ||||||||||
Polyol / humectants, 1% -10% | × | × | × | × | × | × | × | × | × | × |
Preservatives, 0.3% -0.8% | × | × | × | × | × | × | × | × | × | × |
Perfume oil, 0.1% -0.4% | × | × | × | × | × | × | × | × | × | × |
Deionized water, amount, 100% | × | × | × | × | × | × | × | × | × | × |
Ultraviolet absorber of the present invention, 1% -20% | × | × | × | × | × | × | × | × | × | × |
Ingredient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
Table 1-3 The ultraviolet absorber, 0% -30% | × | × | × | × | × | × | × | × | × | × |
O / W emulsion spray
Ingredient | 1 | 2 | 3 | 4 | 5 | 6 |
Emulsifier | ||||||
Alkyl phosphate, 0.1% to 5% | × | × | × | |||
Glucoside derivative, 0.1% to 5% | × | × | × | |||
Solubilizer | ||||||
Ethoxylated glyceryl ether, 0.1% -1% | × | × | ||||
Polysorbate, 0.1% -1% | × | × | ||||
Ethoxylated oleyl ether. 0.1% -1% | × | × | ||||
Film-forming agents | ||||||
PVP / VA copolymer, 1% -10% | × | × | × | |||
PVM / MA copolymer, 1% -10% | × | × | × | |||
The oil phase, 5% -20% | × | × | × | × | × | × |
Natural oil (Meadowfoam, Jojoba, Macadamia, etc.) | ||||||
Fatty acid ester | ||||||
Mineral oil | ||||||
Silicone | ||||||
Alcohols, 0% -50% | × | × | × | × | × | × |
Thickener, 0.1% -0.5% | × | × | × | × | × | × |
Polyacrylate | ||||||
Aluminum / magnesium | ||||||
Gum | ||||||
Neutralizing agent, 0% -1% | × | × | × | × | × | × |
Polyol / moisturizing agents, 1% to 5% | × | × | × | × | × | × |
Chelating agents (eg EDTA), 0% -0.2% | × | × | × | × | × | × |
Antioxidants, 0.05% -0.2% | × | × | × | × | × | × |
Deionized water, amount, 100% | × | × | × | × | × | × |
Perfume oil, 0.1% -0.5% | × | × | × | × | × | × |
Preservatives, 0.4% -1% | × | × | × | × | × | × |
Ultraviolet absorber of the present invention, 1% -20% | × | × | × | × | × | × |
Table 1-3 The ultraviolet absorber, 0% -30% | × | × | × | × | × | × |
G-aqueous
Ingredient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 |
Thickeners | ||||||||||||
Natural thickening agent, 1% to 5% | × | × | × | × | ||||||||
Semi-synthetic thickeners, 1% to 5% | × | × | × | × | ||||||||
Synthetic thickener, 0.3% -1.3% | × | × | × | × | ||||||||
Neutralizing agent, 0.5% -1.5% | × | × | × | × | × | × | × | × | × | × | × | × |
Polyol - humectants, 5% -50% | × | × | × | × | × | × | × | × | × | × | × | × |
Ingredient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 |
Film-forming agent / conditioner | ||||||||||||
Polyquaternium series 1% -5% | × | × | × | × | × | × | ||||||
PVM / MA copolymer, 1% to 5% | × | × | × | × | × | × | ||||||
Preservatives, 0.5% -1% | × | × | × | × | × | × | × | × | × | × | × | × |
Chelating agents (eg EDTA), <0.1% | × | × | × | × | × | × | × | × | × | × | × | × |
Deionized water, amount, 100% | × | × | × | × | × | × | × | × | × | × | × | × |
Perfume oil, 0.05% -0.4% | × | × | × | × | × | × | × | × | × | × | × | × |
Solubilizer | ||||||||||||
Ethoxylated glyceryl ether, 0.1% to 5% | × | × | × | |||||||||
Polysorbate, 0.1% to 5% | × | × | × | |||||||||
Ethoxylated oleyl ether, 0.1% to 5% | × | × | × | × | × | × | ||||||
Ultraviolet absorber of the present invention, 1% -20% | × | × | × | × | × | × | × | × | × | × | × | × |
Table 1-3 The ultraviolet absorber, 0% -30% | × | × | × | × | × | × | × | × | × | × | × | × |
Oil Gel
Ingredient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
Thickeners | ||||||||||
Hydrogenated lecithin, 1% -10% | × | × | ||||||||
Silica dimethyl silyl salt (silica dimethyl silylate), 1% -10% | × | × | ||||||||
Silica, 1% -5% | × | × | ||||||||
C 24-28Alkyl dimethyl polysiloxane, 1% -5% | × | × | ||||||||
Aluminum or magnesium stearate, 1% to 5% | × | × | ||||||||
Polyol humectant, 5% -70% | × | × | × | × | × | × | × | × | × | × |
The oil phase, 20% -90% | ||||||||||
Dioctanoyl ether | × | × | × | |||||||
Phenyl trimethicone | × | × | ||||||||
Hydrogenated polyisobutene | × | |||||||||
Isopropyl isostearate | × | × | ||||||||
Gel base oil (mineral oil and hydrogenated butylene / Ethylene or ethylene / propylene-styrene copolymer) | × | × | ||||||||
Silicone waxes, 1% -10% | × | × | × | × | × | × | × | × | × | × |
Dimethyl polysiloxane polyol behenate | ||||||||||
Dimethyl polysiloxane polyol stearate | ||||||||||
Perfume oil, 0.1% -0.5% | × | × | × | × | × | × | × | × | × | × |
Antioxidants, 0.05% -0.2% | × | × | × | × | × | × | × | × | × | × |
Ultraviolet absorber of the present invention, 1% -20% | × | × | × | × | × | × | × | × | × | × |
Ingredient | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
Table 1-3 The ultraviolet absorber, 0% -30% | × | × | × | × | × | × | × | × | × | × |
Light / Dry cosmetic oils
Ingredient | 1 | 2 | 3 | 4 |
Lipophilic base | ||||
Hydrocarbon oil, 30% -70% | × | × | ||
Branched or non-branched fatty acid esters, 10% -50% | × | × | ||
Light sensitizer (lightfeelagent) | ||||
Silicone / siloxane, 0% -10% | × | × | ||
Perfluorinated oils and perfluoro ether, 0% -10% | × | × | ||
Tackifier, 0% -10% | × | × | × | X |
Wax | ||||
Long-chain acids and alcohols, esters of 0% -2% | × | × | × | × |
Antioxidant, 0.1% -1% | × | × | × | × |
Increase dissolution / dispersing agent, 0% -5% | × | × | × | × |
Perfume oil, 0.1% -0.5% | × | × | × | × |
Ultraviolet absorber of the present invention, 1% -20% | × | × | × | × |
Table 1-3 The ultraviolet absorber, 0% -30% | × | × | × | × |
Table 1-3 The ultraviolet absorber, 0% -30%...
Table 1-3 The ultraviolet absorber, 0% -30%... | |
SD alcohol 40,0% -8% | × |
Propellant 8% -15% | × |
Nonionic emulsifier / surfactant, 0.5% -3% | × |
Corrosion inhibitors, 0% -1% | × |
Perfume oil, 0.1% -0.5% | × |
Preservatives, 0.1% -1% | × |
Other, 0% -1% | × |
Ultraviolet absorber of the present invention, 1% -20% | × |
Table 1-3 The ultraviolet absorber, 0% -30% | × |
Rod-like product
Ingredient | |
Wax, 15% -30% | × |
Natural and silicone oil, 20% -75% | × |
Lanolin derivatives, 5% -> 50% | × |
Ingredient | |
Lanolin esters | × |
Acetylated lanolin | × |
Lanolin oil | × |
Pigment and a pigment, 10% -15% | × |
Antioxidant, 0.1% -0.8% | × |
Perfume oil, 0.1% -2% | × |
Preservatives, 0.1% -0.7% | × |
Ultraviolet absorber of the present invention, 1% -20% | × |
Ultraviolet absorber of the present invention, 1% -20%... | × |
Ultraviolet absorber of the present invention, 1% -20%...
Ingredient | 1 | 2 |
Liquid Foundation | ||
Powder to 10% -15% | × | |
Oil phase, 30% -40%; 75% (only for anhydrous form | × | |
Thickening / suspending agent, 1% to 5% | × | |
Film-forming polymer, 1% -2% | × | |
Antioxidant, 0.1% -1% | × | |
Perfume oil, 0.1% -0.5% | × | |
Preservatives, 0.1% -0.8% | × | |
Deionized water, amount, 100% | × | |
Pressed powder | ||
Powder phase, 15% -50% | × | |
Oil phase, 15% -50% | × | |
Polyol phase, 5% -15% | × | |
Antioxidant, 0.1% -1% | × | |
Perfume oil, 0.1% -0.5% | × | |
Preservatives, 0.1% -0.8% | × | |
For both products in the form | ||
Ultraviolet absorber of the present invention, 1% -20% | × | × |
Table 1-3 The ultraviolet absorber, 0% -30% | × | × |
Conditioning Shampoo
Ingredient | 1 |
First surfactant (listed previously) 5% -10% | × |
Second surfactant (listed previously) 5% -15% | × |
Foam stabilizer (listed previously), 0% -5% | × |
Deionized water, 40% -70% | × |
Active, 0% -10% | × |
Conditioner | × |
refatting agents | × |
Wetting agent | × |
Ingredient | 1 |
Thickener / rheology modifiers, 0% -3% | × |
Humectant, 0% -2% | × |
pH adjusting agents, 0% -1% | × |
Preservatives 0.05% -1% | × |
Perfume oil, 0.1% -1% | × |
Antioxidants, 0.05% -0.20% | × |
Chelating agent (EDTA), 0% -0.2% | × |
Opacifiers, 0% -2% | × |
Ultraviolet absorber of the present invention, 1% -20% | × |
Table 1-3 The ultraviolet absorber, 0% -30% | × |
The present invention prominent cosmetic preparations due to its excellent protection of human skin from
Sun damage.
In the following Examples, the percentages refer to weight percentages. In the case of triazine derivatives
, The amount refers to the amount of pure substances.
Example 1:2 - ((2,4 - (2 - ethyl-hexyloxy) - phenyl)) -4 - ((2 - hydroxy - 4 - (2 -
Ethylhexyloxy - phenyl)) -6 - (4 - methoxyphenyl) -1,3,5 - triazine
The 31.5 g of the formula (101a) of 2,4 - ((4 - (2 - ethyl-hexyloxy) -2 - hydroxy) -
Phenyl)) -6 - (4 - methoxyphenyl) -1,3,5 - triazine and 200 g of dimethylformamide and 13.5
G of sodium methoxide solution (30%) into the reaction flask, the flask contents were stirred slowly
Dimethylformamide was heated to the boiling point (155 ℃), through the separator to remove a substance from the reaction
Alcohol. Then the contents of the flask were cooled to 80 ℃, adding 14.7 g of 3 - (bromomethyl) heptane.
The reaction mass was stirred at 80 ℃ for 14 hours. To complete alkylation, followed by 5 g
3 - (bromomethyl) heptane, the reaction continued at 80 ℃ for 6 hours.
Of 1500 ml of water and 8 g formic acid was added to the reaction mass, the organic phase was extracted into about
300 ml of toluene. By vacuum at 80 ℃ (0.5 mbar) toluene solution was concentrated by evaporation
(Residue 37.4 g).
Using 2 - butanol can be crystallized to give pure compound (actually colorless crystals; mp = 53-55
℃).
This compound has excellent solubility in
- Solubility in tricaprylin> 30%
- Di-C12-C
13Alkyl malonate solubility of> 25%.
Chromatographic Properties
λ max | 322nm |
ε | 50,443 l / (mol / cm) |
E [1%, 1cm] (in dioxane) | 681.62 |
Example 2
Similarly to Example 1, using butyl bromide (13.9 g) as for the compound (101a) for alkylation
Technology, to obtain 34 g of the formula (102) the compound.
Analysis of data:
Found: C = 74.1%; H = 8.7%; N = 5.9%
Calculated: C = 73.8%; H = 8.4%; N = 6.1%
Example 3
As described in Example 1, using allyl bromide (12 g) for the compound (101a) for alkylation
Technology, to obtain 32 g of the formula (103) the compound.
Analysis of data:
Found: C = 73.8%; H = 8.2%; N = 5.9%
Calculated: C = 73.7%; H = 8.0%; N = 6.3%
Example 4
According to Example 1 with benzyl bromide (10.3 g) as for the compound (101a) is alkylated to give
To 35.7 grams of the formula (104) the compound.
Analysis of data:
Analysis of data:...
Analysis of data:...
Example 5
The 20.2 g (0.05 mole) of the formula (101b) of 2,4 - bis (2,4 - dihydroxyphenyl
Yl)) -6 - (4 - methoxyphenyl) -1,3,5 - triazine with 200 ml methyl cellosolve ()
And 8.8 g (0.11 mol) of 50% sodium hydroxide solution introduced together with a stirrer, a dropping
Funnel, internal thermometer, condenser, and a 500 ml sulfonation flask. Was stirred at 80 ℃ 30
Minutes and at the same temperature, slowly added dropwise dissolved in 25 ml of methyl cellosolve 23.2
G (0.12 mol) of 3 - (bromomethyl) heptane. Can be monitored by thin layer chromatography alkylation. In
112-114 ℃ reacted for 8 hours, the material can no longer be detected. Concentrated by evaporation to dryness,
The residue was extracted into 100 ml of toluene / hexane (volume ratio of 7/3), and filtered to remove insoluble
Thereof. For purification by silica gel chromatography (column: diameter = 5 cm, length = 60 cm).
Formula (101a) the compound of bright yellow viscous resins crystallize after a few weeks. Yield:
24.6 g (78.4% of theoretical yield). Seeding can accelerate crystallization.
...
)
And 8.8 g (0.11 mol) of 50% sodium hydroxide solution introduced together with a stirrer, a dropping
Funnel, internal thermometer, condenser, and a 500 ml sulfonation flask. Was stirred at 80 ℃ 30
Minutes and at the same temperature, slowly added dropwise dissolved in 25 ml of methyl cellosolve 23.2
G (0.12 mol) of 3 - (bromomethyl) heptane. Can be monitored by thin layer chromatography alkylation. In
112-114 ℃ reacted for 8 hours, the material can no longer be detected. Concentrated by evaporation to dryness,
The residue was extracted into 100 ml of toluene / hexane (volume ratio of 7/3), and filtered to remove insoluble
Thereof. For purification by silica gel chromatography (column: diameter = 5 cm, length = 60 cm).
Formula (101a) the compound of bright yellow viscous resins crystallize after a few weeks. Yield:
24.6 g (78.4% of theoretical yield). Seeding can accelerate crystallization.
...
Examples 6-8
Similarly to Example 3, using 90 parts of formula (101a) the compound described in the following
Combinations:
Similarly to Example 3, using 90 parts of formula (101a) the compound described in the following
Combinations:...
Similarly to Example 3, using 90 parts of formula (101a) the compound described in the following
Combinations:...
-10 Parts of formula (104) and the compound (= Example 8).
Application Example
For cosmetic embodiment of photoprotection
The method of measuring light protection factor is Diffey and Robson in J.Soc.Cosmet.
Chem.40 ,127-133 (1989) disclosed a method for the analyzer used for measuring the SPF
(Optometrix, SPF290).
To determine the light stability, the filter agent material was dissolved in ethanol (c = 1X10-5-5X10
-5M)
, And in the stirring, in a quartz cell using a metal halide (Macam) (IUVB=0.4-
8.0mW/cm
2) Irradiation. For transformation of the solar spectrum (CIE D65 standard daylight, normalized to
IUVB=0.127mW/cm
2), Calculated over the product of the light intensity of the wavelength resolution and the integration purple
290-400 nm in outer absorbent corresponding absorption values and dividing the light intensity above the product D65
The degree of integration and the ultraviolet absorber in the 290-400 nm corresponding absorption values. In order to obtain
To the corresponding half-life of the sun irradiation value of the factor to be multiplied by a metal halide lamp
Degradation half-life values of irradiation. Through the absorbance at the maximum at a wavelength violet light extinction
Spectroscopic measurement and subsequently the outer exponential fit, thereby measuring the light irradiation for the photodegradation
Half-life values. Using the method described in D65 light corresponding to obtain the half-life of photodegradation
Values.
Example 9: including formula (101), (103) and (106) of the compound of the O / W emulsions
(A):
UV absorber mixture consisting of 95% by weight of the formula (101a) of the compound and 5% by weight
Formula (101) composed of compounds: 3g
UV absorber mixture consisting of 95% by weight of the formula (101a) of the compound and 5% by weight
Formula (101) composed of compounds: 3g...
UV absorber mixture consisting of 95% by weight of the formula (101a) of the compound and 5% by weight
Formula (101) composed of compounds: 3g...
Stearate 1 g
Cetyl alcohol 0.5 g
Polysorbate 20 0.2 g
(B):
Propylene glycol 4 g
Propyl paraben 0.05 g
Methylparaben 0.15 g
Triethanolamine 0.1 g
carbomer 934 0.1 克
Water to 100 ml
Emulsion
Phase (A):
First, the UV absorber mixture is dissolved in sesame oil. To which (A) Other
Ingredients and mix.
First, the UV absorber mixture is dissolved in sesame oil. To which (A) Other
Ingredients and mix....
First, the UV absorber mixture is dissolved in sesame oil. To which (A) Other
Ingredients and mix....
Emulsion:
In the application of mechanical energy violent agitation case, the (A) was slowly added to (B) in the. Through
The volume was adjusted by addition of water to 100 ml.
Determination of sun protection factor and light stability values are listed in Table 2.
Table 2 | Concentration | Sun protection factor * | Light Stability ** [h] |
95% by weight of the formula (101a) of the And 5% by weight compound of formula (101) consisting of the compound UV absorber mixture | 3% | 9.1 | 1500 |
*) According to Diffey and Robson measured by
**) In D65 light irradiation in ethanol solution photodegradation half-life values
By changing the concentration of UV absorbers, sunscreen factor can be changed.
The results showed that the active substance mixture has a high light stability, and even when a low-
Can also be obtained when the concentration of excellent sun protection factor.
Example 10: daily care cream, O / W type
INCI-Name% w / w (on a percentage of available time)
Part A
Glyceryl stearate (and) Cetyl / stearyl alcohol (and)
Cetyl palmitate ester (and) coco glycerides 4.0
Ceteareth-12 4.0
Sixteen / eighteen alcohol 2.0
Dioctanoyl ether 4.5
Dioctanoyl ether 4.5...
Dioctanoyl ether 4.5...
Ethylhexyl triazone 1.0
Benzylidene malonate ester polysiloxane 2.0
HDI / trimethylol hexyl - lactone crosslinked polymer (and) Silica 5.0
Stearyl dimethicone 1.0
Dimethicone 2.0
Cetyl alcohol 0.8
80% of the formula (101) and 20% of the compound of formula (101a)
A mixture of compounds
2.0
Part B
The amount of water to 100
Water (and) scleroglucan (and) phenoxyethanol 2.0
Glycerin 2.0
Part C
Steareth-10 allyl ether / acrylate copolymer 0.45
Phenoxyethanol (and) Methylparaben (and) hydroxy
Benzoate (and) Butylparaben (and)
Propylparaben (and) isobutyl paraben 0.7
Part D
Aqua (and) tocopheryl acetate (and) caprylic / capric acid triglyceride
(And) Polysorbate 80 (and) lecithin 4.0
Part E
Water (and) sodium hydroxide q.s.
Perfume suitable amount
Manufacturing Description:
Part A and Part B are independently heated to 80 ℃. The Part A was poured under continuous stirring into unit
Points B, respectively. Ultra Turrax After the mixture was homogenized at 11000rpm for 20 seconds. The mixed
Was cooled to 60 ℃, adding some C. Below 30 ℃, adding some D, and hydroxide
The pH was adjusted to sodium between 6.5-7.0, and finally add spices.
Example 11: sunscreen, O / W type
INCI-Name% w / w (in order to provide the percentage of total)
Part A
Multi-glycero-3 methyl glucose distearate 2.0
Decyl oleate 5.7
Isopropyl palmitate 5.8
Caprylic / capric acid triglyceride 6.5
80% of the formula (101) and a compound
20% of the formula (101a) the mixture of the compound 2.0
Methoxy cinnamic acid ethyl hexyl acrylate 5.0
Cetyl alcohol 0.7
Part B
Glycerin 3.0
Carbomer 0.3
The amount of water to 100
Part C
Phenoxyethanol (and) Methylparaben
(And) Ethylparaben (and)
Butylparaben (and) Propylparaben
Butylparaben (and) Propylparaben...
Butylparaben (and) Propylparaben...
Methylene bis - phenol benzotriazolyl tetramethylbutylphenol (and)
Aqua (and) decyl glucoside (and) Propylene Glycol (and) Xanthan gum 8.0
Water 20.0
Part E
Water (and) sodium hydroxide q.s.
Perfume suitable amount
Manufacturing Description:
Part A and Part B are independently heated to 75 ℃. The section A is poured while stirring into unit
Points B, respectively. Ultra Turrax at 11000rpm with the mixture homogenized for 15 seconds. The mixture
Cooled to 60 ℃, and part of the introduction portion C D. The mixture was homogenized again for a short (5 seconds
/ 11000rpm), and stirring at moderate cooled again. At room temperature with sodium hydroxide solution
The pH was adjusted to 5.5-6.0. Finally, add spices.
Example 12: UV protection of water daily care
INCI-Name% w / w (percent when provided)
Part A
Oleth-3 phosphate 0.6
Steareth-21 2.5
Steareth-2 1.0
Cetyl alcohol 0.8
Stearyl alcohol 1.5
Tribehenin 0.8
Isohexadecane 8.0
90% of the formula (101) and a compound
10% of the formula (101a) the mixture of the compound 5.0
Part B
The amount of water to 100
Glycerin 2.0
Methylene-bis-benzotriazole tetramethylbutylphenol phenol
(And) Aqua (and) decyl glucoside (and) Propylene Glycol (and) Xanthan gum 3.0
Disodium EDTA 0.1
Part C
Water 20.0
Diazolidinyl urea (and) iodopropynyl butyl carbamate ester 0.15
Propylene glycol 4.0
Part D
Sodium acrylate copolymer (and) Paraffinium Liquidum (and)
PPG-1 Trideceth-6 1.5
Ring five polysiloxane 4.5
PEG-12 dimethicone 2.0
Tocopheryl acetate 0.45
Water (and) citric acid amount
Part E
Perfume suitable amount
Manufacturing Description:
Part A and Part B are independently heated to a maximum of 75 ℃, the portion A with continuous stirring poured into
The portion B. Immediately after the emulsification of the portion D SF 1202 and SF 1288 introduced into the mixing
Material, after which, with the Ultra Turrax homogenizer at 11000rpm for 30 seconds. Cooled to 65
℃, the introduction of SALCARESC91. At 50 ℃, adding some C. At 35 ℃ or less
Temperature, the introduction of vitamin E acetate, followed by adjusting the pH with citric acid. Added at room temperature
Into section E.
Example 13: sunscreen, O / W type
INCI-Name% w / w (percent when provided)
Part A
Multi-glycero-3 methyl glucose distearate 2.0
Decyl oleate 5.7
Palmitic acid isopropyl ester 5.8
Caprylic / capric acid triglyceride 6.5
Formula (101) and the compound (90%) and butyl - methoxy dibenzoyl -
Methane (CAS No. 70356-09-1) (10%) of a mixture of 2.0
Methoxy cinnamic acid ethyl hexyl acrylate 5.0
Cetyl alcohol 0.7
Part B
Glycerin 3.0
Carbomer 0.3
The amount of water to 100
Part C
Phenoxyethanol (and) Methylparaben (and) hydroxy
Benzoate (and) Butylparaben (and)
Propylparaben (and) isobutyl paraben 0.5
Part D
Methylene bis - phenol benzotriazolyl tetramethylbutylphenol (and)
Methylene bis - phenol benzotriazolyl tetramethylbutylphenol (and)...
Methylene bis - phenol benzotriazolyl tetramethylbutylphenol (and)...
Part E
Water (and) sodium hydroxide q.s.
Perfume suitable amount
Manufacturing Description:
Part A and Part B are independently heated to 75 ℃. The Part A was poured into a stirring portion B
Medium. Ultra Turrax at 11000rpm in the mixture homogenized for 15 seconds. The mixture was cooled
To 60 ℃, introduction portion C and portion D. The mixture is homogenized again in a short (5 seconds
/ 11000rpm). After cooling again, at moderate stirring at room temperature with sodium hydroxide
The pH values. A pH value of a solution of between 5.50-6.00. Finally, add spices.
Example 14: sunscreen, O / W type
INCI-Name% w / w (percent when provided)
Part A
Multi-glycero-3 methyl glucose distearate 2.0
Decyl oleate 5.7
Palmitic acid isopropyl ester 5.8
Caprylic / capric acid triglyceride 6.5
Formula (101) and the compound (90%) and UvinulA Plus
(CAS No. 302776-68-7) (10%) of a mixture of 2.0
Methoxy cinnamic acid ethyl hexyl acrylate 5.0
Cetyl alcohol 0.7
Part B
Glycerin 3.0
Carbomer 0.3
The amount of water to 100
Part C
Phenoxyethanol (and) Methylparaben (and)
Ethylparaben (and) butylparaben
(And) Propylparaben (and) isobutyl paraben 0.5
Part D
Methylene bis - phenol benzotriazolyl tetramethylbutylphenol (and)
Aqua (and) decyl glucoside (and) Propylene Glycol (and) Xanthan gum 8.0
Water 20.0
Part E
Water (and) sodium hydroxide q.s.
Perfume suitable amount
Manufacturing Description:
Part A and Part B are independently heated to 75 ℃. The Part A was poured into a stirring portion B
Medium. Ultra Turrax at 11000rpm in the mixture homogenized for 15 seconds. Cooled to 60 ℃,
Part C and Part introducing D. The mixture is homogenized again in a short (5 seconds
/ 11000rpm). After cooling again at room temperature, under stirring at moderate sodium hydroxide
The pH value was adjusted to 5.50-6.00. Finally, add spices.
Part A and Part B are independently heated to 75 ℃. The Part A was poured into a stirring portion B
Medium. Ultra Turrax at 11000rpm in the mixture homogenized for 15 seconds. Cooled to 60 ℃,
Part C and Part introducing D. The mixture is homogenized again in a short (5 seconds
/ 11000rpm). After cooling again at room temperature, under stirring at moderate sodium hydroxide
The pH value was adjusted to 5.50-6.00. Finally, add spices....
Part A and Part B are independently heated to 75 ℃. The Part A was poured into a stirring portion B
Medium. Ultra Turrax at 11000rpm in the mixture homogenized for 15 seconds. Cooled to 60 ℃,
Part C and Part introducing D. The mixture is homogenized again in a short (5 seconds
/ 11000rpm). After cooling again at room temperature, under stirring at moderate sodium hydroxide
The pH value was adjusted to 5.50-6.00. Finally, add spices....
Part A
Multi-glycero-3 methyl glucose distearate 2.0
Decyl oleate 5.7
Decyl oleate 5.7...
Decyl oleate 5.7...
Formula (101) and the compound (90%) and camphor Benzyliden
(CAS No. 36861-47-9) (10%) of a mixture of 2.0
Methoxy cinnamic acid ethyl hexyl acrylate 5.0
Cetyl alcohol 0.7
Part B
Part B...
Carbomer 0.3
Part B...
Part C
Phenoxyethanol (and) Methylparaben (and) hydroxy
Benzoate (and) Butylparaben (and)
Propylparaben (and) isobutyl paraben 0.5
Part D
Methylene bis - phenol benzotriazolyl tetramethylbutyl
(And) Aqua (and) decyl glucoside (and) Propylene Glycol (and) Xanthan gum 8.0
Water 20.0
Part E
Water (and) sodium hydroxide q.s.
Perfume suitable amount
Manufacturing Description:
Part A and Part B are independently heated to 75 ℃. The Part A was poured into a stirring portion B
Medium. Ultra Turrax at 11000rpm in the mixture homogenized for 15 seconds. Cooled to 60 ℃,
Part C and Part introducing D. The mixture is homogenized again in a short (5 seconds
/ 11000rpm). After cooling again at room temperature, under stirring at moderate, with sodium hydroxide
PH adjustment. A pH value of a solution of between 5.50-6.00. Finally, add spices.
Claims (13)
1 An ultraviolet absorbent composition, comprising:
(a) 1-99% by weight of the following formula (1), the hydroxyphenyl triazine compound:
Wherein, R1、R
2And R3Independently of one another C1-C
18Alkyl; C2-C
10Alkenyl; or phenyl C1-C
4Alkyl group;
R
4Is hydrogen; or C1-C
5Is hydrogen; or C...
Is hydrogen; or C...1) And the component (a) the type of
Hydroxyphenyl-triazine, (b2) Benzotriazole, (b3) 1 - (4 - tert-butylphenyl) -3 - (4 - methoxyphenyl)
Propane-1 ,3 - dione or butyl methoxy dibenzoyl methane, and (b4) Camphor derivative selected from the following
Biology: 3 - (4'-methyl) benzylidene - Endo-2 - one, 3 - benzylidene - Endo-2 - one, N-[2 (and
4) -2 - O borneol -3 - ylidene - methyl] - benzyl] acrylamide polymer, 3 - (4'-trimethylammonium) -
Benzylidene - Endo-2 - one methyl sulfate, 3,3 '- (1,4 - phenylene secondary methyl) - bis (7,7 -
Dimethyl-2 - O bicyclo [2.2.1] heptane-1 - methanesulfonic acid) and salts, 3 - (4'-sulfo) benzylidene -
Endo-2 - one and salts thereof;, and camphor benzalkonium methosulfate.
(2) as claimed in claim 1, ultraviolet absorbent composition which comprises 5-95% of component (a) and
95-5% of component (b).
3 according to claim 1 or 2, an ultraviolet absorbent composition, wherein R1、R
2And R3Independent of each other
Site is C5-C
12Group.
As claimed in claim 1 or 2, an ultraviolet absorbent composition, wherein R1、R
2And R3Meaning phase
Same.
5 according to Claim 1 or 2, an ultraviolet absorbent composition, wherein the component (a) equal to the amount
The formula:
As claimed in claim 1 or 2, an ultraviolet absorbent composition, wherein in the formula (1),
R
1And R2Is a C5-C
12Alkyl group;
R
3Is a C2-C
12Alkenyl; and
R
4Is hydrogen; or C1-C
5Group.
As claimed in claim 1 or 2, an ultraviolet absorbent composition, wherein in the formula (1),
R
1And R2Is a C5-C
12Alkyl group;
R
3Is phenyl; or phenyl-C1-C
4Alkyl; and
R
4Is hydrogen; or C1-C
5Group.
As claimed in claim 1 of the formula (1) as the UV absorber compound of purposes.
9 Use according to claim 8, wherein in the formula (1) compound is used as human skin and hair
Light protective agent.
10 includes according to claim 1 of formula (1) wherein the cosmetic formulations.
11 according to claim 1 comprising an ultraviolet absorbent composition of the cosmetic preparation.
12. According to claim 10 or 11, cosmetic preparation comprising absorbed within the UVB
Additional substances ultraviolet radiation.
13 for the preparation according to claim 1 of formula (1) a compound of the formula which comprises
(1c) phenyl magnesium bromide compound with the Grignard reaction of cyanuric chloride (formula (1b)) Reaction of formula
(1d) of dichloro-triazine compounds, in the presence of a Lewis acid by resorcinol (formula (1e)) of
Friedel-Crafts acylation of resorcinol into groups, according to the group R1、R
2And R3Meaning,
Etherified by alkylation of formula (1f) the compound of the ortho position and the free hydroxyl groups, of formula (1),
Compounds, the process follows the following scheme:
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02405188 | 2002-03-12 | ||
EP02405188.0 | 2002-03-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1642522A CN1642522A (en) | 2005-07-20 |
CN100528847C true CN100528847C (en) | 2009-08-19 |
Family
ID=27798957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB038059150A Expired - Lifetime CN100528847C (en) | 2002-03-12 | 2003-03-04 | Uv absorber compositions comprising a hydroxyphenyltriazine compound |
Country Status (11)
Country | Link |
---|---|
US (1) | US7344706B2 (en) |
EP (1) | EP1482904B1 (en) |
JP (1) | JP4088254B2 (en) |
KR (1) | KR100979659B1 (en) |
CN (1) | CN100528847C (en) |
AT (1) | ATE390950T1 (en) |
AU (1) | AU2003214092B2 (en) |
BR (1) | BRPI0308369B1 (en) |
DE (1) | DE60320093T2 (en) |
ES (1) | ES2302916T3 (en) |
WO (1) | WO2003075875A1 (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004064797A1 (en) * | 2003-01-20 | 2004-08-05 | Ciba Specialty Chemicals Holding, Inc. | Triazine derivatives as uv absorbers |
FR2864898B1 (en) * | 2004-01-09 | 2006-03-24 | Expanscience Lab | ORGANO-MINERAL SOLAR SCREEN COMPOSITION SUITABLE FOR PROPULSION PUMP APPLICATION |
JP2005225771A (en) * | 2004-02-10 | 2005-08-25 | Shiseido Co Ltd | Oil-in-water type emulsified composition |
US8158136B2 (en) | 2004-08-18 | 2012-04-17 | L'oréal | Emulsification system for use in cosmetics |
US7431917B2 (en) | 2004-10-19 | 2008-10-07 | L'oreal | Photostable photoprotective compositions comprising dibenzoylmethane and bis-resorcinyl triazine compounds and a compound that accepts the excited triplet level energy of said dibenzoylmethane(s) |
ES2264624B1 (en) * | 2004-12-16 | 2007-11-01 | Isdin, S.A. | NEW DERIVATIVES OF TRIAZINE, AS WELL AS PROCEDURES FOR THEIR OBTAINING AND ITS USE AS PROTECTIVE AGENTS AGAINST UV RADIATION. |
ES2272164B1 (en) | 2005-06-03 | 2008-04-01 | Isdin, S.A. | NEW DERIVATIVES OF PIRROLILTRIAZINE AS WELL AS PROCEDURES FOR THEIR OBTAINING AND ITS USE AS PROTECTIVE AGENTS AGAINST RADIATIONUV. |
US7615231B2 (en) | 2005-10-24 | 2009-11-10 | Fan Tech, Ltd. | Methods for enhancing the morphology, tone, texture and/or appearance of skin or hair using a meadowlactone |
US20070264216A1 (en) * | 2006-05-11 | 2007-11-15 | Mcentire Edward Enns | Water resistant sunscreen formulas with sulfopolyesters and phosphate ester surfactants |
WO2008067928A1 (en) * | 2006-12-04 | 2008-06-12 | Isdin S.A. | Uv absorbing compositions containing a pyrrolyltriazine |
KR102645302B1 (en) * | 2007-12-14 | 2024-03-11 | 바스프 에스이 | Sunscreen compositions comprising colour pigments |
JP5384034B2 (en) * | 2008-06-04 | 2014-01-08 | 株式会社Adeka | Method for producing 2,4,6-tris (hydroxyphenyl) -1,3,5-triazine compound |
JP5388270B2 (en) * | 2008-06-04 | 2014-01-15 | 株式会社Adeka | Method for producing 2,4,6-tris (hydroxyphenyl) -1,3,5-triazine compound |
EP2305207B1 (en) * | 2008-06-20 | 2012-08-29 | Shiseido Company, Ltd. | Hair cosmetic |
DE102008034957B4 (en) * | 2008-07-25 | 2011-12-22 | Beiersdorf Ag | Oil migration inhibited product |
EP2344120A1 (en) * | 2008-11-13 | 2011-07-20 | B & T S.r.l. | Cosmetic use of natural emulsifiers |
EP2210887A1 (en) | 2009-01-14 | 2010-07-28 | Isdin, S.A. | Bis resorcinyl triazine derivatives as protecting agents against UV radiation |
JP4834775B2 (en) * | 2010-03-04 | 2011-12-14 | 株式会社 資生堂 | Sunscreen composition |
DE202013103395U1 (en) * | 2013-07-26 | 2013-08-13 | Sasol Germany Gmbh | Transparent sunscreen compositions and their use |
EP3348549B1 (en) * | 2015-09-09 | 2020-06-17 | Kaneka Corporation | Methods respectively for producing 2,4,6-tris(2-hydroxy-3-methyl-4-alkoxyphenyl)-1,3,5- triazine compound and 2,4,6-tris(2,4-dihydroxy-3-methylphenyl)-1,3,5-triazine |
JP7393205B2 (en) * | 2017-10-05 | 2023-12-06 | 株式会社Adeka | Compound, latent ultraviolet absorber, composition, cured product, and method for producing cured product |
KR102677284B1 (en) | 2017-11-16 | 2024-06-24 | 제이에스알 가부시끼가이샤 | Composition for forming a resist underlayer film, resist underlayer film and method for forming the same, method for producing a patterned substrate, and compound |
US20220183934A1 (en) * | 2019-03-12 | 2022-06-16 | Basf Se | Sunscreen compositions containing porous metal oxide spheres |
CN112321520B (en) * | 2020-10-30 | 2022-06-03 | 马鞍山科思化学有限公司 | One-pot synthesis process of bis-ethylhexyloxyphenol methoxyphenyl triazine |
CN113149919B (en) * | 2021-05-07 | 2022-01-11 | 湖北师范大学 | Etherification synthesis method of ultraviolet absorbent Tianlaishi S |
CN118027806A (en) * | 2024-02-01 | 2024-05-14 | 江苏大自然智能家居有限公司 | Water-based UV (ultraviolet) photo-curing coating for wood floor and preparation method thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5872165A (en) | 1996-12-18 | 1999-02-16 | Basf Corporation | Coating composition and method for reducing ultraviolet light degradation |
DE19817293A1 (en) | 1998-04-18 | 1999-10-21 | Beiersdorf Ag | Use of unsymmetrically substituted triazine derivatives to achieve or increase the solubility of symmetrically substituted triazine derivatives in oil components |
IL146778A0 (en) | 1999-06-18 | 2002-07-25 | Ciba Sc Holding Ag | Micropigment mixture |
-
2003
- 2003-03-04 EP EP03709744A patent/EP1482904B1/en not_active Expired - Lifetime
- 2003-03-04 CN CNB038059150A patent/CN100528847C/en not_active Expired - Lifetime
- 2003-03-04 WO PCT/EP2003/002200 patent/WO2003075875A1/en active IP Right Grant
- 2003-03-04 JP JP2003574151A patent/JP4088254B2/en not_active Expired - Fee Related
- 2003-03-04 KR KR1020047014265A patent/KR100979659B1/en active IP Right Grant
- 2003-03-04 BR BRPI0308369-1A patent/BRPI0308369B1/en not_active IP Right Cessation
- 2003-03-04 US US10/507,295 patent/US7344706B2/en active Active
- 2003-03-04 ES ES03709744T patent/ES2302916T3/en not_active Expired - Lifetime
- 2003-03-04 AT AT03709744T patent/ATE390950T1/en not_active IP Right Cessation
- 2003-03-04 DE DE60320093T patent/DE60320093T2/en not_active Expired - Lifetime
- 2003-03-04 AU AU2003214092A patent/AU2003214092B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP1482904A1 (en) | 2004-12-08 |
ATE390950T1 (en) | 2008-04-15 |
ES2302916T3 (en) | 2008-08-01 |
US7344706B2 (en) | 2008-03-18 |
US20050129632A1 (en) | 2005-06-16 |
AU2003214092A1 (en) | 2003-09-22 |
DE60320093T2 (en) | 2009-06-04 |
CN1642522A (en) | 2005-07-20 |
KR20040093129A (en) | 2004-11-04 |
EP1482904B1 (en) | 2008-04-02 |
BRPI0308369B1 (en) | 2015-05-26 |
AU2003214092B2 (en) | 2008-05-15 |
WO2003075875A1 (en) | 2003-09-18 |
DE60320093D1 (en) | 2008-05-15 |
KR100979659B1 (en) | 2010-09-02 |
JP2005532273A (en) | 2005-10-27 |
BR0308369A (en) | 2005-01-11 |
JP4088254B2 (en) | 2008-05-21 |
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