CN100512843C - Chinese herbal composite prescription for controlling sea fish paralembus digitiformis - Google Patents
Chinese herbal composite prescription for controlling sea fish paralembus digitiformis Download PDFInfo
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- CN100512843C CN100512843C CNB2005100447552A CN200510044755A CN100512843C CN 100512843 C CN100512843 C CN 100512843C CN B2005100447552 A CNB2005100447552 A CN B2005100447552A CN 200510044755 A CN200510044755 A CN 200510044755A CN 100512843 C CN100512843 C CN 100512843C
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Abstract
Disclosed is a Chinese herbal composite prescription for controlling sea fish paralembus digitiformis, wherein the medicinal constituents include (by weight ratio) European verbena 40%, Kulian 30%, baikal skullcap root 30%, the preparing process consists of disintegrating, passing through 100 mesh sieve, and mixing homogeneously.
Description
Affiliated technical field
The invention belongs to the Aquatic product specific complex Chinese herb medicine of treatment seawater fish shield ciliate disease, is to the young postlarva of seawater fish with form method for preparation of drug and the application process thereof that fish shield balantidiasis prevents and treats under the artificial cultivation condition.
Background technology
The protozoa species that parasitizes tissues such as marine products economic fish body surface, the gill filament, internal organs and organ is a lot, and some kind can cause the serious disease of seawater fish.Along with flourish in the whole world of marine fish culture industry, particularly to have implemented since the high density intensification artificial cultivation, the fish disease that these kinds cause is on the rise, and also can cause enormous economic loss.Yet, countries in the world bias toward viral to the research of marine fish disease and bacterial disease on, and less to the research of protozoan disease, data is scattered, the research of control medicine is deficient especially.From calendar year 2001, we have carried out the sick investigation and the Study on etiology learned of disease popularity of system to coastal main fish culture zone, Shandong Province, find that several make the morbific parasitic protozoa class of seawater fish disease, for example Paralembus digitiformis disease (Scuticociliatosis), flagellosis (Giardiasis), cryptocaryoniosis (Cryptocaryoniosis) and trichodinasis (Trichodiniasis).Wherein the highest with the Paralembus digitiformis disease incidence rate, the harm maximum that causes has brought than serious economy loss for the breed dealer, so be widely regarded as (the Bo-Young et al. of one of most important disease in the industrialized culture Fish, 2001, Iglesias R et al.2001).From breed variety, Fish such as turbot, Paralichthys olivaceus, puffer are vulnerable to the infection of the fine worm of shield most, and the example of being annihilated after infecting happens occasionally.
The fine Eimeria facultative parasite of shield is sought free living generally speaking, is food with the fine particulate matter (antibacterial, microalgae, protozoon etc.) that suspends.But under some environment, these ciliate can show as parasitics, become Scavenger, engulf the cell of some Mollusca, shell-fish, Fish and organize residue and in its tissue the growth, the breeding (Yoshinaga T et al.1993), thereby cause tissue injury.
The research work of domestic and international generation for the sea fish paralembus digitiformis disease, nosetiology, taxonomy etc. only has the minority report, research to its control medicine then rarely has report, and be limited to the laboratory screening stage, do not see the compound prescription and the patented product that are used to produce, and the oral drugs of Paralembus digitiformis disease there is no report both at home and abroad.Domestic in China, the traditional method of control Paralembus digitiformis disease is frequently to use highly concentrated formaldehyde solution, usually with 200～600 * 10
-6Concentration is soaked the fish body.Use formalin can only kill the shield ciliate of ill fish body surface, then do not have effect, and high concentration throws in and can cause the damage of fish soma, and edible fish formaldehyde is residual and serious environmental is polluted invading intravital polypide.
Summary of the invention
The purpose of this invention is to provide a kind of Aquatic product special-purpose medicaments that can treat the sea fish paralembus digitiformis disease and this disease be had certain preventive effect.By using this medicine to reach the obvious treatment effect, significantly improve the breed survival rate, cultured output and economic benefit to the cultured fishes of suffering from Paralembus digitiformis disease.
The present invention makes by following technical scheme:
Its experiment flow is: carry out Paralembus digitiformis disease Epidemiological study widely, grasp its epidemiology characteristics; Collect disease fish sample and to carry out the separating of the fine worm of cause of disease shield, cultivation, evaluation and artificial tieback infection experiment former to determine to cause a disease; Carrying out external medicine kills except that testing with screening of medicaments; Carrying out pharmaceutical formulation combination and clinical prevention effect test determines and optimization of C.
Its ingredient and proportioning are: Herba Verbenae 40%, Melia azedarach L. 30%, Radix Scutellariae 30%, and to pulverize and sieve through 100 orders, mix homogeneously forms.
The present invention and prior art contrast its characteristics:
1, the invention belongs to the compound medicine of Chinese herbal medicine of Aquatic product special use, be applicable to oral form dispenser, the property of medicine is gentle and have no side effect, and is the technology initiative of orally taken for curing seawater fish shield balantidiasis.Only need in proportion medicine to be added to during use to make pharmaceutical chemistry in the bait, operational approach is easy, with low cost, is applicable to large-scale seed cultivation and breeding production.
2, the ingredient of this medicine by the fish bulk absorption after, can significantly improve seawater fish to the resistance in the shield fibre.For the sick fish that is subjected to the fine insect infection of shield, can efficiently kill the intravital ciliate of fish, overcome general insecticide and only be applicable to the parasiticidal defective of body surface.When the clinical trial proof was used for oral medication, the cure rate of this medicine can reach more than 80%.
3, Chinese herbal medicine is the green of generally acknowledging, the medicine that has no side effect.Utilization the present invention will play positive impetus to reducing or replace the use of formaldehyde, improve to culture the marketable fish quality and ensure food safety.
The specific embodiment
The fine worm of shield can cause culturing fish body systemic infection, and except that body surface infected, ill fish interior tissue and organ were also found a large amount of polypide parasitisms.Therefore, the oral administration treatment obviously is absolutely necessary.
The inventor has taken the lead in carrying out the research of control Paralembus digitiformis disease special-purpose medicaments, has developed a kind of efficient, nontoxic special-purpose oral compound Chinese herb, called after " the fine worm of shield is clear ", and its application process carried out the clinical prevention demonstration.The result of clinical experiment shows that these special-purpose oral drugs of employing can reach tangible prevention and curative effect to this disease.
Its experiment flow is: carry out Paralembus digitiformis disease Epidemiological study widely, grasp its epidemiology characteristics; Collect disease fish sample and to carry out the separating of the fine worm of cause of disease shield, cultivation, evaluation and artificial tieback infection experiment former to determine to cause a disease; Carrying out external medicine kills except that testing with screening of medicaments; Carrying out pharmaceutical formulation combination and clinical prevention effect test determines and optimization of C.
Its ingredient and proportioning are: Herba Verbenae 40%, Melia azedarach L. 30%, Radix Scutellariae 30%, and to pulverize and sieve through 100 orders, mix homogeneously forms.
During year May in January, 2004 to 2005, this research has been carried out clinical trial in man of ground such as Yantai, Shandong, Qingdao, Weifang, sunshine, Wendeng City morbidity plant, and the marine fish kind of test comprises turbot, Paralichthys olivaceus, puffer, Yellowtail fish etc.The application process and the actual therapeutic effect of this medicine determined in clinical experiment, and table 1 has been summed up the operating position of each family.
Table 1 compound Chinese herb " the fine worm of shield is clear " is to the clinical prevention effect analysis of sea fish paralembus digitiformis disease
Annotate: owing to the commercial interest relation, the title inconvenience of test site man is open in this table.
Drug dosage and using method:
(1) oral
Oral consumption: addition is 3～4 gram/kilogram feedstuffs during prevention, 5～6 gram/kilogram feedstuffs during treatment.
Orally administered method:, take by weighing medicine in proportion according to above-mentioned drug dosage and the bait weight of throwing something and feeding.Earlier medicine is mixed with egg (1～2 egg/per kilogram bait) and beat evenly with blender, its mixture is slowly poured in the dryness granular bait for fish, one side predominate mixing makes medicine evenly be adhered to the granular bait for fish surface; Spread out and can throw something and feed after the lucifuge dry in the sun solidified egg in 2 hours.Then directly in proportion medicine is incorporated in the bait raw material for moist bait, stirs, extrusion modling is made pharmaceutical chemistry and is thrown something and fed after freezing.Sooner or later throw something and feed every day two meal pharmaceutical chemistry, throwing something and feeding continuously 10～14 days is a course of treatment.
(2) dipping
The dipping consumption: concentration is 10 * 10 during dipping
-6, promptly every cube of water body adds 10 gram medicines.
Dipping application process: by the appeal consumption, take by weighing an amount of medicine earlier and be soaked in the hot water, boil elimination residue after 3～4 hours, get and splash in the fishpond after leachate suitably dilutes with iron or earthen container temperature.Dipping every day required about 10 hours, logotype 3 days.During the dipping treatment, stop exchanged water, but will keep suitable water level and sufficient dissolved oxygen.
Prove that by a large amount of control clinical trials the treatment of this special medicament has the obvious treatment effect to Paralembus digitiformis disease.For many breed producer has retrieved a large amount of economic losses, the curative effect that the raiser who is tried generally reacts " shield fibre worm is clear " is good in the clinical practice process.The present invention has started the precedent of sea fish paralembus digitiformis disease herbal control technology, cultures survival rate to improving, and ensures that the breeding production stable and high yields has crucial meaning.
Claims (1)
1, a kind of Chinese herbal medicine preparation method of preventing and treating seawater fish shield balantidiasis is characterized in that its ingredient and proportioning, and its weight ratio is: Herba Verbenae 40%, Melia azedarach L. 30%, Radix Scutellariae 30%, and to pulverize and sieve through 100 orders, mix homogeneously forms.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100447552A CN100512843C (en) | 2005-09-23 | 2005-09-23 | Chinese herbal composite prescription for controlling sea fish paralembus digitiformis |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100447552A CN100512843C (en) | 2005-09-23 | 2005-09-23 | Chinese herbal composite prescription for controlling sea fish paralembus digitiformis |
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| CN1762460A CN1762460A (en) | 2006-04-26 |
| CN100512843C true CN100512843C (en) | 2009-07-15 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103301250B (en) * | 2013-06-06 | 2015-08-12 | 镇江天和生物技术有限公司 | A kind of herbal composite preventing and treating Fish balantidiasis |
| CN104974949B (en) * | 2014-04-08 | 2018-02-13 | 国家***第一海洋研究所 | A kind of screening technique for seawater fish shield infusorian cause of disease insecticidal bacteria |
| CN104830728B (en) * | 2015-05-06 | 2016-05-04 | 国家***第一海洋研究所 | A kind of providencia rettgeri |
| CN104800469A (en) * | 2015-05-20 | 2015-07-29 | 山东亚康药业股份有限公司 | Traditional Chinese medicine preparation for treating pathogenesis of turbot of aquatic animals |
| CN105199999B (en) * | 2015-11-15 | 2018-02-27 | 国家***第一海洋研究所 | A kind of deep layer Wang Zunong Salmonella and its application |
| CN106719163A (en) * | 2016-11-18 | 2017-05-31 | 蚌埠市金牛湾农业科技发展有限公司 | A kind of prevention and controls of grass carp stress disease |
| CN110075144B (en) * | 2019-06-19 | 2021-06-11 | 北京生泰尔科技股份有限公司 | Application of notopterygium root in preparing medicine for resisting scuticociliatida |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1326679A (en) * | 2001-06-22 | 2001-12-19 | 丁小武 | Pure plant disease treatment insecticide and its producing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1326679A (en) * | 2001-06-22 | 2001-12-19 | 丁小武 | Pure plant disease treatment insecticide and its producing method |
Non-Patent Citations (1)
| Title |
|---|
| 大菱鲆盾纤毛虫病防治技术. 窦海鸽.渔业致富指南. 2004 * |
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Assignee: Qingdao Hanhe Animal And Plant Medicine Co., Ltd. Assignor: Inst of Huanghai Sea Marine Products, Chinese Academy of Aquatic Product Science Contract record no.: 2010370000465 Denomination of invention: Chinese herbal composite prescription for controlling sea fish paralembus digitiformis Granted publication date: 20090715 License type: Exclusive License Open date: 20060426 Record date: 20100819 |
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Granted publication date: 20090715 Termination date: 20110923 |