CN100463666C - Composition for preparation for external use on skin and method of using the same - Google Patents
Composition for preparation for external use on skin and method of using the same Download PDFInfo
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- CN100463666C CN100463666C CNB038255774A CN03825577A CN100463666C CN 100463666 C CN100463666 C CN 100463666C CN B038255774 A CNB038255774 A CN B038255774A CN 03825577 A CN03825577 A CN 03825577A CN 100463666 C CN100463666 C CN 100463666C
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Abstract
A composition comprising a compound represented by the following general formula (1) and a specific ingredient. In the general formula (1), R<1> represents -CH2OH or COOR<6>, wherein R<6> represents hydrogen, C1-3 alkyl, or a cation capable of forming a salt with COO-; R<2> to R<5> each independently represents hydrogen or methyl; and ...A... represents =C(CH3)-, -C(CH3)=, -C(=CH2)-, -CH(CH3)-, or -C(OH)(CH3)-.
Description
Technical field
The whitening effect and the good skin preparations for extenal use of anti-aging effect that the present invention relates to contain the physiologically active ingredient of specific compound and contain specific drug effect agent.
Background technology
At present, in order to give the certain drug effects of skin preparations for extenal use such as emulsion, emulsifiable paste, astringent, beauty and make-up cream, toilet articles, dispersion liquid, ointment, liquor, aerosol, alite paste, paste, liniment, all active ingredient in the middle of them, have been added.
For example, in order to prevent or to improve the brown patch that produces owing to skin darkening that Exposure to Sunlight produces, by pigmentation or freckle etc., added ascorbic acid, intacellin, glutathione, hydroquinone, etc. whitening agent.And on the other hand,, added vitamin A and cell activators such as soybean extract, Sargassum extract in order to prevent or to improve owing to age growth, be exposed to the reduction of wrinkle of skin that ultraviolet etc. produces and loose, tension force and elastic force.
In addition, found to belong to the Cistus ladaniferus L. of Cistaceae, Cistus creticus L., Cistusmonoperiensis L., the stem of Cistus salvifolius etc., branch, hot water extract or ethanol such as leaf, extracts such as hexane, there is very strong inhibition to produce melanic effect, the cell-stimulating effect, antibacterial action, be based on the activity of laudanum acids, and then, find its extract or thick laudanum acids carried out molecular distillation and laudanum base-7-alkene-15-acid of obtaining, laudanum base-8 (17)-alkene-15-acid, laudanum base-8-alkene-15-acid has very strong inhibition to produce melanic effect, the cell-stimulating effect, antibacterial action.And then found that again their salt or methyl and ethyl ester agent and then their Reducing agent also have same activity.(spy opens flat 11-No. 302219 communiques etc.)
Summary of the invention
It is good to the purpose of this invention is to provide a kind of skin Caring effect, especially whitening effect and/or the good skin preparations for extenal use of anti-aging effect.
A kind of form of the present invention is: (A) with following general formula (1)
(in the general formula (1), R
1Expression-CH
2OH or COOR
6, R
6Expression hydrogen, carbon number are that 1～3 low alkyl group maybe can form COO
-With the cation of salt, R
2～R
5Independent respectively expression hydrogen atom or methyl ... A ... expression=C (CH
3)-,-C (CH
3)=,-C (=CH
2)-,-CH (CH
3)-or-C (OH) (CH
31 kind of the chemical compound of)-) expression or 2 kinds or more than and
Contain one or more the constituent that is selected among the following drug effect agent group: (B) Radix Asparagi extract, A.acutiloba's extract, Cortex Mori extract, Rhizoma Chuanxiong extract, rose hip extract, the rasp berry extract, Radix Sophorae Flavescentis extract, Cortex Acanthopancis extract, coffee-extract, the Testa oryzae extract, wheat malt germ extract, Herba Asari extract, the crab apple extract, white Bulbus Lilii extract, Radix Paeoniae Alba extract, Folium Camelliae sinensis extract, the molasses extract, Fructus Vitis viniferae extract, Flos lupuli (Flos Humuli Lupuli) extract, Flos Rosae Rugosae extract, Fructus Chaenomelis extract, Radix Scutellariae extract, Sargassum extract, dibenzylatiooluene, butylated hydroxyarisol, mannitol, beta-carotene, quercetin, Quercitroside, rutin, vitamin E and derivant thereof, Herba Erodii extract, Herba Saxifragae extract, senna extract, the Herba leucadis ciliatae extract, glycyrrhizic acid and derivant thereof, enoxolone and derivant thereof, vitamin B and derivant thereof, Radix Gentianae extract, Herba Houttuyniae extract, peony extract, Aloe extract, the arnica montana extract, the Herba Hyperici Erecti extract, yellow tiller extract, Flos Lonicerae extract, the Salvia farinacea extract, the Betula platyphylla Suk. extract, Folium perillae extract, biennial wormwood extract, chamomile extract, daisy extract, Radix Sangusorbae extract, the Nasturtium officinale extract, big Flos Inulae extract, Ramulus Sambuci Williamsii extract, the Pollen Typhae extract, the Fructus Sapindi Mukouossi extract, eucalyptus extracts, the Herba Astragali Melilotoidis (Herba Astragali Sinici) extract, vitamin A and derivant thereof, tartaric acid, malic acid, glycol acid, succinic acid, serine, glutamic acid, hydroxyproline, theanine, the 2-pyrrolidone-5-carboxylic acid, Cordyceps extract, soybean extract, Radix Dauci Sativae extract, Fructus Hordei Vulgaris extract, Fagus sinensis Oliv. bud extract, Semen Ginkgo extrac, Herba Centellae extract, yeast extract, the lactobacillus extract, the lactobacillus extract, 2-hydroxyl-4-methoxy benzophenone, 2-hydroxyl-4-methoxy benzophenone-5-sulfonic acid, 2-hydroxyl-4-methoxy benzophenone-5-sodium sulfonate, p-methoxycinnamate-2-ethylhexyl, the 4-tert-butyl group-4 '-methoxyl group DBM, the Radix althaeae roseae extract, the Rhizoma Acori Graminei extract, Radix Rehmanniae extract, the chesnut extract, Radix Malvae sylvestris (Althaea officinalis) extract, Fructus Pruni extract, Lay lemon extract, the rasp berry extract, the Semen Armeniacae Amarum extract, Fructus Lycopersici esculenti extract, phospholipid and derivant thereof, sweet tea extract, the coltsfoot extract;
Quince seed extract, Radix Glycyrrhizae extract, Semen Coicis extract, black currant (black room palpus tool profit) fruit extract, Flos Inulae (dolly) extract, cranberry fruit extract, Caulis Spatholobi extract, Betula platyphylla Suk. resin, the real extract of arrow car, Radix et Caulis Opuntiae Dillenii extract, Fructus Momordicae extract, astaxanthin and derivant and rutin derivant.
As a kind of form of the present invention, above-mentioned (B) provide be selected from respectively (B1) and (B2) in one or more above-mentioned drug effect agent group in constituent.Wherein (B1) comprising: the Radix Asparagi extract, A.acutiloba's extract, Cortex Mori extract, Rhizoma Chuanxiong extract, rose hip extract, the rasp berry extract, Radix Sophorae Flavescentis extract, Cortex Acanthopancis extract, coffee-extract, the Testa oryzae extract, wheat malt germ extract, Herba Asari extract, the crab apple extract, white Bulbus Lilii extract, Radix Paeoniae Alba extract, Folium Camelliae sinensis extract, the molasses extract, Fructus Vitis viniferae extract, Flos lupuli (Flos Humuli Lupuli) extract, Flos Rosae Rugosae extract, Fructus Chaenomelis extract, Radix Scutellariae extract, Sargassum extract, dibenzylatiooluene, butylated hydroxyarisol, mannitol, beta-carotene, quercetin, Quercitroside, rutin, vitamin E and derivant thereof, Herba Erodii extract, Herba Saxifragae extract, senna extract, the Herba leucadis ciliatae extract, glycyrrhizic acid and derivant thereof, enoxolone and derivant thereof, vitamin B and derivant thereof, Radix Gentianae extract, Herba Houttuyniae extract, peony extract, Aloe extract, the arnica montana extract, the Herba Hyperici Erecti extract, yellow tiller extract, Flos Lonicerae extract, the Salvia farinacea extract, the Betula platyphylla Suk. extract, Folium perillae extract, biennial wormwood extract, chamomile extract, daisy extract, Radix Sangusorbae extract, the Nasturtium officinale extract, big Flos Inulae extract, Ramulus Sambuci Williamsii extract, the Pollen Typhae extract, the Fructus Sapindi Mukouossi extract, eucalyptus extracts, the Herba Astragali Melilotoidis (Herba Astragali Sinici) extract, vitamin A and derivant thereof, tartaric acid, malic acid, glycol acid, succinic acid, serine, glutamic acid, hydroxyproline, theanine, the 2-pyrrolidone-5-carboxylic acid, Cordyceps extract, soybean extract, Radix Dauci Sativae extract, Fructus Hordei Vulgaris extract, Fagus sinensis Oliv. bud extract, Semen Ginkgo extrac, Herba Centellae extract, yeast extract, the lactobacillus extract, the lactobacillus extract, 2-hydroxyl-4-methoxy benzophenone, 2-hydroxyl-4-methoxy benzophenone-5-sulfonic acid, 2-hydroxyl-4-methoxy benzophenone-5-sodium sulfonate, p-methoxycinnamate-2-ethylhexyl, the 4-tert-butyl group-4 '-methoxyl group DBM, the Radix althaeae roseae extract, the Rhizoma Acori Graminei extract, Radix Rehmanniae extract, the chesnut extract, Radix Malvae sylvestris (Althaea officinalis) extract, Fructus Pruni extract, Lay lemon extract, the rasp berry extract, the Semen Armeniacae Amarum extract, Fructus Lycopersici esculenti extract, phospholipid and derivant thereof, sweet tea extract, the coltsfoot extract;
The Quince seed extract.In aforementioned (B), (B2) comprising: Radix Glycyrrhizae extract, Semen Coicis extract, black currant (black room palpus tool profit) fruit extract, Flos Inulae (dolly) extract, cranberry fruit extract, Caulis Spatholobi extract, Betula platyphylla Suk. resin, the real extract of arrow car, Radix et Caulis Opuntiae Dillenii extract, Fructus Momordicae extract, astaxanthin and derivant and rutin derivant.
Constituent of the present invention is as skin preparations for extenal use, in particular as skin-whitening external agent or prevent that skin aging external agent from being good.
" skin Caring " this speech in this manual, need be from comprising as suppressing the skin darkening that pigmentation, gloomy skin, Exposure to Sunlight etc. cause, prevent and improve brown patch, freckle, prevent and improve broad sense such as wrinkle and explain, be construed as " whitening " and reach " preventing to wear out " and be included in its scope.
As a kind of form of the present invention, it is to be selected from Cistus ladaniferus L., Cistus creticus L. in the Cistaceae, Cistus monoperiensis L., and the chemical compound that extracts of one or more plants of the plant group that constitutes of Cistus salvifolius that the represented chemical compound of above-mentioned general formula (1) is provided; Perhaps modulate the above-mentioned constituent of chemical compound for this chemical compound; And contain the represented chemical compound of above-mentioned general formula (1) with being selected from, the Cistus ladaniferus L. of Cistaceae, Cistus creticus L., Cistusmonoperiensis L., and the chemical compound that extracts of one or more plants of the plant group that constitutes of Cistus salvifolius, composite above-mentioned constituent.
From another point of view, the present invention also provides and has comprised the method that above-mentioned constituent is applied to the obstruction melanin generation of skin; Comprise the skin-whitening method that above-mentioned constituent is applied to skin; Comprise the method that prevents skin aging that above-mentioned constituent is applied to skin; The using method of above-mentioned constituent as skin preparations for extenal use; Use above-mentioned constituent to make the using method of skin preparations for extenal use; Improve one or more the using method of from the drug effect agent group of above-mentioned (B), selecting one or more of drug effect of the represented chemical compound of above-mentioned general formula (1); Improve one or more the using method of from the drug effect agent group of above-mentioned (B), selecting one or more of inhibition melanin generative capacity of the represented chemical compound of above-mentioned general formula (1); Improve one or more the using method of from the drug effect agent group of above-mentioned (B), selecting one or more of cell-stimulating ability of the represented chemical compound of above-mentioned general formula (1); The drug effect reinforcing agent of one or more of the chemical compound that the above-mentioned general formula (1) that one or more of the drug effect agent group of above-mentioned by being selected from (B) are formed is represented.
The specific embodiment
Below, the embodiment that just constituent of the present invention is applied to skin preparations for extenal use is elaborated.
Skin preparations for extenal use of the present invention contains one or more physiologically active ingredient (hereinafter referred to as " (A) composition ") of the represented chemical compound of following general formula (1).
In the above-mentioned general formula (1), R
1Expression-CH
2OH or COOR
6, R
6Expression hydrogen, carbon number are that 1～3 low alkyl group maybe can form COO
-Cation with salt.Carbon number is 1～3 low alkyl group, and no matter straight or branched can.Abovementioned alkyl can be enumerated methyl, ethyl, n-pro-pyl, isopropyl.And can form-COO
-Can enumerate Na with the cation of salt
+, K
+, and NH
4 +Etc. cation.
In the above-mentioned general formula (1), R
2～R
5Independent respectively expression hydrogen atom or methyl ... A ... expression=C (CH
3)-,-C (CH
3)=,-C (=CH
2)-,-CH (CH
3)-or-C (OH) (CH
3)-.
The chemical compound of above-mentioned general formula (1) expression can extract from plant.In addition, the extract of plant is sold on market, and (Labdanum (gum) purification thing, Ji Bodan (ジ ボ ダ Application) corporate system etc.) also can use the market sales in the present invention.And then, as extract, also can be after acquisition-COOH acid, become ester agent, Reducing agent or salt such as methyl, ethyl after, R
1Use as (A) composition.
About extracting the floristics of the represented chemical compound of above-mentioned general formula (1), if contain the plant of this chemical compound, then without any qualification, but, especially use the plant of Cistus ladaniferus L., Cistus creticusL., Cistus monoperiensis L., Cistus salvifolius (Cistaceae) more favourable.They can use separately, or two or more collocation is used.
The extract part of plant is not particularly limited, and can extract from leaf, branch, bark.Can after having taked each position, extract, perhaps also can after having taked each position, extract again after the drying at once.Extracting method preferably carries out with one or more the solvent that is selected from water, lower alcohol, petroleum ether and hydrocarbon.At this, so-called lower alcohol is meant that carbon number is 1～4 alcohol, special particular methanol, ethanol etc.As petroleum ether, can use well-knownly, also can sell with market.As the hydrocarbon solvent, can enumerate and be aqueous aliphatic carbonization hydrogen, alicyclic hydrocarbon, aromatic series hydrocarbon under the room temperature, preferred especially room temperature is aqueous aliphatic carbonization hydrogen, aromatic series hydrocarbon down, wherein, and Hydrocarbon such as further preferred hexane, toluene.
Though it is different because of the solvent of the kind of above-mentioned plant and use to extract operation, usually can be the plant of cutting off, under the temperature of room temperature to 50 ℃, be immersed in the above-mentioned solvent and carry out.Can the agitation as appropriate solvent in the immersion.And then, can also use devices such as well-known Soxhlet withdrawal device.Extract the time that needs, be generally 3 hours～between 48 hours.Can also be the leaf of above-mentioned plant, branch or pulverizings back such as do with the steam distillation or the method for in hot water, boiling, extraction then.In this case, vapor distillation or in hot water extraction natant glue branch pull out, it is separated with insoluble matter in solvent and obtains in said extracted.The laudanum acids that contains 25～35 quality % (following usefulness " % " expression) like this in the extract of Huo Deing.
Can be from crude extract or commercially available extract that above-mentioned plant extracts directly as the use of (A) composition, but also can be further, from crude extract or commercially available extract, the represented chemical compound of above-mentioned general formula (1) is made with extra care, used as (A) composition then.Below, from comprising the crude extract or the commercially available product of laudanum base (ラ Block ど)-7-alkene-15-acid, laudanum base-8 (17)-alkene-15-acid, laudanum base-8-alkene-15-acid blend, the method of refining each composition describes as typical example, but the present invention is not subjected to the restriction of following method.
To crude extract or commercially available extract, under the reduced pressure of 0.1～0.5mmHg, carry out molecular distillation, collect 160 ℃～230 ℃ fraction, contain the mixture of laudanum base-7-alkene-15-acid, laudanum base-8 (17)-alkene-15-acid, laudanum base-8-alkene-15-acid in this fraction.Can directly use their acid blend as (A) composition, also can be modulated into ester agent, salt or Reducing agents such as methyl, ethyl as required after, use their mixture.
Can also further from this acid blend, isolate three kinds of acid.Specifically be, the mixture of this acid is dissolved in the ethanol, make its reaction having under the condition of catalyst sulfuric acid coexistence,, utilize the dioxide/silica gel chromatography of the dioxide/silica gel that silver nitrate handled then as the ethyl ester agent.Carry out post with hexane and clean, then separate out with the dissolving of 1% acetic acid ethyl hexane.At first laudanum base-8-alkene-15-acetoacetic ester is separated out, and then is to separate out by the order of laudanum base-7-alkene-15-acetoacetic ester, laudanum base-8 (17)-alkene-15-acetoacetic ester.The solvent distillation is removed, obtain the pure product of ethyl ester agent respectively.Can from the ethyl ester agent that obtains, obtain free acid with the method that adds water decomposition.And then, can make free acid and diazomethane reaction, obtain methyl ester.
Extracts such as stem, branch, leaf such as the Cistus ladaniferus L. that belongs to Cistaceae of Huo Deing, Cistus creticus L., Cistusmonoperiensis L., Cistus salvifolius reach acid, methyl ester, ethyl ester or their the two or more mixture etc. that obtain from this extract and can be used as the use of (A) of the present invention composition like this.That is, as embodiments of the present invention, (A) composition can enumerate (i), (ii), (iii), (iv) skin preparations for extenal use.(i) be hot water extract or organic solvent (ethanol, hexane etc.) extracts such as the stem of Cistus ladaniferus L., the Cistus creticusL., Cistus monoperiensis L., the Cistus salvifolius etc. that belong to Cistaceae, branch, leaf; (ii) be selected from one or more of laudanum base-7-alkene-15-acid, laudanum base-8 (17)-alkene-15-acid and laudanum base-8-alkene-15-acid for what the extract of above-mentioned (i) or thick laudanum acids carried out obtaining behind the molecular distillation; (iii) be salt or the methyl or the ethyl ester agent of above-mentioned acid (ii); It (iv) is above-mentioned Reducing agent (iii).
In the skin preparations for extenal use of the present invention, the content of the chemical compound that above-mentioned general formula (1) is represented, exsiccant solid portion, preferred 0.00001～5%, more preferably 0.0001～2%.If in this scope, can stablize and mix this plant extract, and can bring into play good skin Caring effect (particularly whiten and prevent aging effect).In addition, when using extracting solution, solute, i.e. the content of drying solid part, if in above-mentioned scope, its extract concentration is not subjected to any restriction.
In the present invention, with (B) composition of (A) composition collocation be selected from below shown in a kind of in the agent, or two or more.Moreover, comprise ester and salt in the following object lesson in " derivant ".
Can enumerate the Radix Asparagi extract, A.acutiloba's extract, Cortex Mori extract, Rhizoma Chuanxiong extract, rose hip extract, the rasp berry extract, Radix Sophorae Flavescentis extract, Cortex Acanthopancis extract, coffee-extract, the Testa oryzae extract, wheat malt germ extract, Herba Asari extract, the crab apple extract, white Bulbus Lilii extract, Radix Paeoniae Alba extract, Folium Camelliae sinensis extract, the molasses extract, Fructus Vitis viniferae extract, Flos lupuli (Flos Humuli Lupuli) extract, Flos Rosae Rugosae extract, Fructus Chaenomelis extract, Radix Scutellariae extract, Sargassum extract, dibenzylatiooluene, butylated hydroxyarisol, mannitol, beta-carotene, quercetin, Quercitroside, rutin, vitamin E and derivant thereof, Herba Erodii extract, Herba Saxifragae extract, senna extract, the Herba leucadis ciliatae extract, glycyrrhizic acid and derivant thereof, enoxolone and derivant thereof, vitamin B and derivant thereof, Radix Gentianae extract, Herba Houttuyniae extract, peony extract, Aloe extract, the arnica montana extract, the Herba Hyperici Erecti extract, yellow tiller extract, Flos Lonicerae extract, the Salvia farinacea extract, the Betula platyphylla Suk. extract, Folium perillae extract, biennial wormwood extract, chamomile extract, daisy extract, Radix Sangusorbae extract, the Nasturtium officinale extract, big Flos Inulae extract, Ramulus Sambuci Williamsii extract, the Pollen Typhae extract, the Fructus Sapindi Mukouossi extract, eucalyptus extracts, the Herba Astragali Melilotoidis (Herba Astragali Sinici) extract, vitamin A and derivant thereof, tartaric acid, malic acid, glycol acid, succinic acid, serine, glutamic acid, hydroxyproline, theanine, the 2-pyrrolidone-5-carboxylic acid, Cordyceps extract, soybean extract, Radix Dauci Sativae extract, Fructus Hordei Vulgaris extract, Fagus sinensis Oliv. bud extract, Semen Ginkgo extrac, Herba Centellae extract, yeast extract, the lactobacillus extract, the lactobacillus extract, 2-hydroxyl-4-methoxy benzophenone, 2-hydroxyl-4-methoxy benzophenone-5-sulfonic acid, 2-hydroxyl-4-methoxy benzophenone-5-sodium sulfonate, p-methoxycinnamate 2-ethylhexyl, the 4-tert-butyl group-4 '-methoxyl group DBM, the Radix althaeae roseae extract, the Rhizoma Acori Graminei extract, Radix Rehmanniae extract, the chesnut extract, Radix Malvae sylvestris (Althaea officinalis) extract, Fructus Pruni extract, Lay lemon extract, the rasp berry extract, the Semen Armeniacae Amarum extract, Fructus Lycopersici esculenti extract, phospholipid and derivant thereof, sweet tea extract, the coltsfoot extract;
Quince seed extract, Radix Glycyrrhizae extract, Semen Coicis extract, black currant (black room palpus tool profit) fruit extract, Flos Inulae (dolly) extract, cranberry fruit extract, Caulis Spatholobi extract, Betula platyphylla Suk. resin, the real extract of arrow car, Radix et Caulis Opuntiae Dillenii extract, Fructus Momordicae extract, astaxanthin and derivant and rutin derivant.
A kind of form of the present invention is for containing one or more the form that is selected from following (B1) extract as above-mentioned (B) composition.(B1) be the Radix Asparagi extract, A.acutiloba's extract, Cortex Mori extract, Rhizoma Chuanxiong extract, rose hip extract, the rasp berry extract, Radix Sophorae Flavescentis extract, Cortex Acanthopancis extract, coffee-extract, the Testa oryzae extract, wheat malt germ extract, Herba Asari extract, the crab apple extract, white Bulbus Lilii extract, Radix Paeoniae Alba extract, Folium Camelliae sinensis extract, the molasses extract, Fructus Vitis viniferae extract, Flos lupuli (Flos Humuli Lupuli) extract, Flos Rosae Rugosae extract, Fructus Chaenomelis extract, Radix Scutellariae extract, Sargassum extract, dibenzylatiooluene, butylated hydroxyarisol, mannitol, beta-carotene, quercetin, Quercitroside, rutin, vitamin E and derivant thereof, Herba Erodii extract, Herba Saxifragae extract, senna extract, the Herba leucadis ciliatae extract, glycyrrhizic acid and derivant thereof, enoxolone and derivant thereof, vitamin B and derivant thereof, Radix Gentianae extract, Herba Houttuyniae extract, peony extract, Aloe extract, the arnica montana extract, the Herba Hyperici Erecti extract, yellow tiller extract, Flos Lonicerae extract, the Salvia farinacea extract, the Betula platyphylla Suk. extract, Folium perillae extract, biennial wormwood extract, chamomile extract, daisy extract, Radix Sangusorbae extract, the Nasturtium officinale extract, big Flos Inulae extract, Ramulus Sambuci Williamsii extract, the Pollen Typhae extract, the Fructus Sapindi Mukouossi extract, eucalyptus extracts, the Herba Astragali Melilotoidis (Herba Astragali Sinici) extract, vitamin A and derivant thereof, tartaric acid, malic acid, glycol acid, succinic acid, serine, glutamic acid, hydroxyproline, theanine, the 2-pyrrolidone-5-carboxylic acid, Cordyceps extract, soybean extract, Radix Dauci Sativae extract, Fructus Hordei Vulgaris extract, Fagus sinensis Oliv. bud extract, Semen Ginkgo extrac, Herba Centellae extract, yeast extract, the lactobacillus extract, the lactobacillus extract, 2-hydroxyl-4-methoxy benzophenone, 2-hydroxyl-4-methoxy benzophenone-5-sulfonic acid, 2-hydroxyl-4-methoxy benzophenone-5-sodium sulfonate, p-methoxycinnamate-2-ethylhexyl, the 4-tert-butyl group-4 '-methoxyl group DBM, the Radix althaeae roseae extract, the Rhizoma Acori Graminei extract, Radix Rehmanniae extract, the chesnut extract, Radix Malvae sylvestris (Althaea officinalis) extract, Fructus Pruni extract, Lay lemon extract, the rasp berry extract, the Semen Armeniacae Amarum extract, Fructus Lycopersici esculenti extract, phospholipid and derivant thereof, sweet tea extract, the coltsfoot extract;
The Quince seed extract.
In above-mentioned (B1) composition, the Radix Asparagi extract, A.acutiloba's extract, Cortex Mori extract, Rhizoma Chuanxiong extract, rose hip extract, the rasp berry extract, Radix Sophorae Flavescentis extract, Cortex Acanthopancis extract, coffee-extract, the Testa oryzae extract, wheat malt germ extract, Herba Asari extract, the crab apple extract, white Bulbus Lilii extract, Radix Paeoniae Alba extract, Folium Camelliae sinensis extract (green tea, black tea, extracts such as oolong tea), the molasses extract, Fructus Vitis viniferae extract, Flos lupuli (Flos Humuli Lupuli) extract, Flos Rosae Rugosae extract, Fructus Chaenomelis extract, Radix Scutellariae extract, Sargassum extract (these are called (C1) composition), though mainly show drug effect as whitening agent separately, but since with above-mentioned (A) composition and usefulness, but play can not obtain when using separately respectively good and whiten and/or the anti-aging effect.Preferred wheat malt germ extract, white Bulbus Lilii extract, Cortex Mori, Folium Camelliae sinensis extract (extracts such as green tea, black tea, oolong tea), Fructus Vitis viniferae extract, Radix Scutellariae extract, the Sargassum extract enumerated.
In above-mentioned (B1) composition, dibenzylatiooluene, butylated hydroxyarisol, mannitol, beta-carotene, quercetin, Quercitroside, rutin, vitamin E and derivant thereof (dl-α (β γ) tocopherol, acetic acid dl-alpha-tocopherol, nicotinic acid dl-alpha-tocopherol, linoleic acid dl-alpha-tocopherol etc.), Herba Erodii extract, Herba Saxifragae extract, senna extract, Herba leucadis ciliatae extract (these are called (D1) composition), though mainly show drug effect as antioxidant separately, but since with above-mentioned (A) composition and usefulness, but play can not obtain when using separately respectively good and whiten and/or the anti-aging effect.Preferredly can enumerate vitamin E and derivant, dibenzylatiooluene, beta-carotene, rutin and Herba Saxifragae extract.
In above-mentioned (B1) composition, glycyrrhizic acid and derivant thereof, enoxolone and derivant thereof, vitamin B and derivant thereof, Radix Gentianae extract, Herba Houttuyniae extract, peony extract, Aloe extract, the arnica montana extract, the Herba Hyperici Erecti extract, yellow tiller extract, Flos Lonicerae extract, the Salvia farinacea extract, the Betula platyphylla Suk. extract, Folium perillae extract, biennial wormwood extract, chamomile extract, daisy extract, Radix Sangusorbae extract, the Nasturtium officinale extract, big Flos Inulae extract, Ramulus Sambuci Williamsii extract, the Pollen Typhae extract, the Fructus Sapindi Mukouossi extract, eucalyptus extracts, Herba Astragali Melilotoidis (Herba Astragali Sinici) extract (these are called (E1) composition), though mainly show drug effect as anti-inflammatory agent separately, but since with above-mentioned (A) composition and usefulness, but play can not obtain when using separately respectively good and whiten and/or the anti-aging effect.Preferredly can enumerate glycyrrhizic acid and derivant, enoxolone and derivant thereof, Aloe extract, yellow tiller extract, Flos Lonicerae extract, Folium perillae extract, chamomile extract, daisy extract, Radix Sangusorbae extract.
In above-mentioned (B1) composition, vitamin A and derivant thereof (Palmic acid retinal, acetic acid Colophonium wet goods), tartaric acid, malic acid, glycol acid, succinic acid, serine, glutamic acid, hydroxyproline, theanine, the 2-pyrrolidone-5-carboxylic acid, Cordyceps extract, soybean extract, Radix Dauci Sativae extract, Fructus Hordei Vulgaris extract, Fagus sinensis Oliv. bud extract, Semen Ginkgo extrac, Herba Centellae extract, yeast extract, the lactobacillus extract, lactobacillus extract (these are called (F1) composition), though mainly show drug effect as cell activator separately, but since with above-mentioned (A) composition and usefulness, but play can not obtain when using separately respectively good and whiten and/or the anti-aging effect.Preferredly can enumerate vitamin A and derivant thereof, hydroxyproline, Radix Dauci Sativae extract, Fructus Hordei Vulgaris extract, Fagus sinensis Oliv. bud extract, Semen Ginkgo extrac, Herba Centellae extract, yeast extract.
In above-mentioned (B1) composition, 2-hydroxyl-4-methoxy benzophenone, 2-hydroxyl-4-methoxy benzophenone-5-sulfonic acid, 2-hydroxyl-4-methoxy benzophenone-5-sodium sulfonate, p-methoxycinnamate-2-ethylhexyl, the 4-tert-butyl group-4 '-methoxyl group DBM (these are called (G1) composition), though mainly prevent that as ultraviolet agent from showing drug effect separately, but since with above-mentioned (A) composition and usefulness, but play can not obtain when using separately respectively good and whiten and/or the anti-aging effect.Preferredly can enumerate 2-hydroxyl-4-methoxy benzophenone, 2-hydroxyl-4-methoxy benzophenone-5-sodium sulfonate, p-methoxycinnamate-2-ethylhexyl, the 4-tert-butyl group-4 '-methoxyl group DBM.
In above-mentioned (B1) composition, Radix althaeae roseae extract, Rhizoma Acori Graminei extract, Radix Rehmanniae extract, chesnut extract, Radix Malvae sylvestris (Althaea officinalis) extract, Fructus Pruni extract, Lay lemon extract, rasp berry extract, Semen Armeniacae Amarum extract, Fructus Lycopersici esculenti extract, phospholipid and derivant thereof (as soybean phospholipid, the soybean phospholipid that adds hydrogen, the Semen sojae atricolor lysozyme chloride fat that adds hydrogen, the Ovum Gallus domesticus Flavus lecithin that adds hydrogen, Ovum Gallus domesticus Flavus lecithin, egg yolk lysophosphatidylcholine etc.), sweet tea extract, coltsfoot extract,
Quince seed extract (these are called (H1) composition), though mainly show drug effect as wetting agent separately, owing to above-mentioned (A) composition and usefulness, but play can not obtain when using separately respectively good and whiten and/or the anti-aging effect.Preferred can enumerate phospholipid and derivant thereof, sweet tea extract, Radix Malvae sylvestris extract, coltsfoot extract,
The Quince seed extract.
In the form that contains above-mentioned (B1) composition, also be that to be selected from one or more the skin preparations for extenal use that contains in the following composition be good as Dermatologic preparation for beautifying: the soybean phospholipid and the p-methoxycinnamate-2-ethylhexyl of white Bulbus Lilii extract, Cortex Mori extract, natural Vitamin E, glycyrrhizic acid dipotassium, yeast extract, interpolation hydrogen.In addition, be selected from one or more the skin preparations for extenal use that contains in the following composition as preventing that skin aging external agent from being good: butylated hydroxytoluene, Radix Dauci Sativae extract, green tea extract, Radix Sangusorbae extract, p-methoxycinnamate-2-ethylhexyl, Palmic acid retinal, coltsfoot extract.
In the skin preparations for extenal use of this form, the combined amount of above-mentioned (B1) composition, though because of kind ((C1) composition～(H1) composition) different, preferred below shown in the scope.If in this scope, when then arrange in pairs or groups with (A) composition, the ageing stability of the composition in preparation and the preparation (A) is unaffected, can make the stronger skin Caring effect of its performance (especially whiten and/or prevent the effect that wears out).
In the skin preparations for extenal use of this form, the combined amount of above-mentioned (C1) composition, preferred 0.00001～10%, more preferably 0.0001～5%.When extract directly uses extracting solution, as the drying solid composition if in this scope, that's all.If in this scope, then can demonstrate better whitening effect, and can obtain usability advantages of good skin external agent.
In the skin preparations for extenal use of this form, the combined amount of above-mentioned (D1) composition, preferred 0.00001～5%, more preferably 0.0001～3%.When extract directly uses extracting solution, as the drying solid composition if in this scope, that's all.If in this scope, then finding has better antioxidant effect, demonstrates good whiten and/or prevent aging effect, and can obtain usability advantages of good skin external agent.
In the skin preparations for extenal use of this form, the combined amount of above-mentioned (E1) composition, preferred 0.00001～5%, more preferably 0.0001～3%.When extract directly uses extracting solution, as the drying solid composition if in this scope, that's all.If in this scope, then finding has better anti-inflammatory effect, demonstrates good whiten and/or prevent aging effect, and can obtain usability advantages of good skin external agent.
In the skin preparations for extenal use of this form, the combined amount of above-mentioned (F1) composition, preferred 0.00001～5%, more preferably 0.0001～3%.When extract directly uses extracting solution, as the drying solid composition if in this scope, that's all.If in this scope, then find to have the better pachylosis effect of improving, demonstrate and good whiten and/or prevent aging effect, and can obtain usability advantages of good skin external agent.
In the skin preparations for extenal use of this form, the combined amount of above-mentioned (G1) composition, preferred 0.001～30%, more preferably 0.01～25%.If in this scope, then find to have the better ultraviolet effect that prevents, demonstrate and good whiten and/or prevent aging effect, and can obtain usability advantages of good skin external agent.
In the skin preparations for extenal use of this form, the combined amount of above-mentioned (H1) composition, preferred 0.001～25%, more preferably 0.01～20%.When extract directly uses extracting solution, as the drying solid composition if in this scope, that's all.If in this scope, then finding has better moistening effect, demonstrates good whiten and/or prevent aging effect, and can obtain usability advantages of good skin external agent.
Other form of the present invention is to contain the form more than a kind or 2 kinds that is selected from (B2) as (B) composition.(B2) be Radix Glycyrrhizae extract, Semen Coicis extract, black currant (black room palpus tool profit) fruit extract, Flos Inulae (dolly) extract, cranberry fruit extract, Caulis Spatholobi extract, Betula platyphylla Suk. resin, the real extract of arrow car, Radix et Caulis Opuntiae Dillenii extract, Fructus Momordicae extract, astaxanthin and derivant and rutin derivant.
The Radix Glycyrrhizae extract that the present invention can use is the root of Glycyrrhiza glabra L. of the Glycyrrhiza of pulse family (Glycyrrhizaglabra L.) or congener and rhizome (the Chinese herbal medicine name is a Radix Glycyrrhizae), uses appropriate solvent, extracts and obtains.It is better to produce the oil-soluble extract that obtains with the hydrophobic organic solvent extraction the Radix Glycyrrhizae from China, Russia etc.
The Semen Coicis extract that the present invention can use is the seed of removing kind of skin (the Chinese herbal medicine name is a Semen Coicis) of the Semen Coicis of the Coix of rice section (Coixlacryma-jobi L.var.ma-yuen Stapf), obtains with the appropriate solvent extraction.
The black currant fruit extract is the black currant (Japanese first name of gooseberry section ribes
Must tool profit, method literary fame Jia Xisi (カ シ ス), Ribes nigrum L.) fruit, extract and the fruit extract that obtains or obtain the fruit squeeze juice with appropriate solvent through squeezing.
The Flos Inulae that the present invention can use (dolly) extract is the head inflorescence of the Flos Inulae of the Inula of Compositae (Inula britannica L.) (Chinese herbal medicine name Flos Inulae) is extracted with appropriate solvent and to obtain.
The cranberry fruit extract that the present invention can use is the fruit of the cranberry of the Oxycoccus of heath bell section (Japanese first name Cranberries Vaccinium macrocorpon Aiton or Vaccinium oxycoccus), extracts and the fruit extract that obtains or obtain the fruit squeeze juice through squeezing with appropriate solvent.
The Caulis Spatholobi extract that the present invention can use is the stem (Chinese herbal medicine name Caulis Spatholobi) of the dry seed of leguminous plant spatholobus suberectus (Spatholobussuberectus) Mucuna birdwoodiana (Mucuna birdwood iana), Mucuna birdwoodiana (Mucunabirdwoodiana Tutcher), fragrant flower Moghania fluminalis(C. B. Clarke) Li rattan (Chinese name fragrant flower Moghania fluminalis(C. B. Clarke) Li rattan, Milletiadielsiana Harms) or bright leaf Moghania fluminalis(C. B. Clarke) Li rattan (Milletia nitida Benth) is extracted with appropriate solvent and to obtain.
The Betula platyphylla Suk. resin that the present invention can use is at Trees burst into bloom, before the phase of coming into leaves, to the trees effusive liquid of boring a hole the Betula platyphylla Suk. of Betulaceae Betula (Betula platyphyllaSukatchuv var.japonica Hara, B.platyphylla Sukatchuv), mahogany birch (B.ErmaniCham.), dog volt birch (ジ ゾ ウ カ Application バ) (B.globispica Shirai), Wang Hua (B.Maximowicziana Regel), drooping birch (B.pendula Roth) and west Betula platyphylla Suk. (B.lental L.) etc.
The real extract of arrow car that the present invention can use is that オ オ バ ヤ シ ヤ Block シ (Alnussieboldiana Matsum.), alder tree (Alnus firma Sieb.Et Zucc.) hair Folium Et Cacumen Alni Japonicae (Alnushirsuta Turcz.) and the fruit of the same clan (yaksha real, vow that car is real) from the Betulaceae Alnus extracts with appropriate solvent and obtain.
The Radix et Caulis Opuntiae Dillenii extract that the present invention can use, if the Cactaceae plant extract gets final product, as appropriate solvent such as the stipes of Indian Fructus Fici (Opuntia ficusindica (L.) Mill or Opuntia dillenii Haw), ォ プ Application テ ィ ア ス ト レ プ カ Application サ (Opuntia Streptacantha) etc., root, fruit, extract and obtain.
The Fructus Momordicae extract that the present invention can use is from the dried fruit of the fruit of the モ モ Le デ ィ カ グ ロ ス ベ ノ リ ィ (Momordica grosvemorii Swingle) of Cucurbitaceae Momordica (name of the country Fructus Momordicae), use appropriate solvent, extract and obtain.
Astaxanthin that the present invention can use and derivant thereof can obtain natural goodses such as krill, salmon, Squaliobarbus ourriculus, Herba Adonidis, red yeast with the appropriate solvent extraction or with chemosynthesis.For example adding the extraction solvent in squama shrimp (Euphausia similis G.O. etc.) extracts, remove the extraction solvent the astaxanthin class extract that obtains behind this liquid filtering or from the further distillation of this extract, after carrying out hydrogenation as required and adding chemical reaction such as water decomposition, can carry out deodorize, refining and use purified astaxanthin through molecular distillation or with means such as column chromatography or high-speed liquid chromatography methods.Astaxanthin is the carotenoid of representing with following formula.Its derivant can be enumerated from the monoesters body of the fatty acid ester apoplexy due to endogenous wind selection of astaxanthin and diester body of the same race or xenogeneic etc.
The rutin derivant that the present invention can use can be the derivant after the rutin water solublity that contains in the Semen Fagopyri Esculenti natural goodses such as (Fagopyrum esculentum Moench) of Sophora japonica L. (Sophora japonicaL.) alabastrum, Polygonaceae pulse family improves.For example, preferably use starchiness such as in rutin, being mixed with dextrin,, in rutin, shift α-glucose rutin of representing for following general formulas of usefulness such as glucose, maltose, wheat tooth trisaccharide, wheat tooth tetroses through the ferment reaction.The rutin derivant of the content of rutin preferred 10～80% wherein.They can be used alone, and perhaps two or more collocation are used.
R represents glucose, maltose, wheat tooth trisaccharide or wheat tooth tetrose in the formula.
Modulating the extraction solvent that above-mentioned belonging to (B2), group's composition used can enumerate, as water, rudimentary 1 valency alcohol (methanol, ethanol, 1-propanol, 2-propanol, 1-butanols, 2-butanols etc.), aqueous multivalence alcohol (glycerol etc.), hydrocarbon (benzene, hexane, pentane etc.), ketone (acetone, methyl ethyl ketone etc.), ethers (diethyl ether, oxolane, dipropyl ether etc.), acetonitrile etc., can use wherein one or more.As the example of preferred extracting method, can enumerate, be the ethanol of 0～100vol% with aqueous concentration, or 1, the 3-butanediol, at room temperature, or after extracting in 1～5 day after heating, filter, the filtrate that obtains is placed again make its ripening about 1 week again, carry out filtering method once again.
In above-mentioned (B2) composition, Radix Glycyrrhizae extract, Semen Coicis extract, black currant (black room palpus tool profit) fruit extract, Flos Inulae (dolly flower) extract, cranberry fruit extract, Caulis Spatholobi extract, Radix et Caulis Opuntiae Dillenii extract, Fructus Momordicae extract, astaxanthin and derivant and rutin derivant (these are called (C2) composition), though also can show its drug effect as whitening agent separately, but because and above-mentioned (A) composition and usefulness, but play can not obtain when using separately respectively good and whiten and/or the anti-aging effect.
In above-mentioned (B2) composition, Radix Glycyrrhizae extract, Caulis Spatholobi extract, the real extract of arrow car, Fructus Momordicae extract, astaxanthin and derivant and rutin derivant (these are called (D2) composition), though also can show its drug effect as antioxidant separately, but because and above-mentioned (A) composition and usefulness, but play can not obtain when using separately respectively good and whiten and/or the anti-aging effect.
In above-mentioned (B2) composition, Radix Glycyrrhizae extract and Caulis Spatholobi extract, (these are called (E2) composition), though also can show its drug effect as anti-inflammatory agent separately, but because and above-mentioned (A) composition and usefulness, but play can not obtain when using separately respectively good and whiten and/or the anti-aging effect.
In above-mentioned (B2) composition, Radix et Caulis Opuntiae Dillenii extract, Fructus Momordicae extract, astaxanthin and derivant thereof and rutin derivant (these are called (F2) composition), though also can show its drug effect as cell activator separately, but because and above-mentioned (A) composition and usefulness, but play can not obtain when using separately respectively good and whiten and/or the anti-aging effect.
In above-mentioned (B2) composition, Radix Glycyrrhizae extract, Semen Coicis extract, black currant (black room palpus tool profit) fruit extract, Flos Inulae (dolly flower) extract, cranberry fruit extract, Caulis Spatholobi extract, Betula platyphylla Suk. resin, the real extract of arrow car, Radix et Caulis Opuntiae Dillenii extract and Fructus Momordicae extract (these are called (G2) composition), though also can show its drug effect as wetting agent separately, but because and above-mentioned (A) composition and usefulness, but play can not obtain when using separately respectively good and whiten and/or the anti-aging effect.
Go up the ideal combined amount of note (B) composition in the skin preparations for extenal use of the present invention, though different because of kind ((C)～(G) composition), in the scope shown in below being preferably in usually.Or in this scope, making itself and (A) composition collocation, the ageing stability of the composition in preparation and the preparation (A) is unaffected, can make the stronger skin Caring effect (especially whitening and/or the anti-aging effect) of its performance.
Moreover, in (B2) composition, just demonstrate the composition of multiple drug effect, repeated for example as the composition of (C2)～(G2), and just repeated composition for example, in preferred combined amount scope separately, the widest scope becomes the preferable range of combined amount.
The combined amount of above-mentioned in the skin preparations for extenal use of this form (C2) composition, preferred 0.00001～10%, more preferably 0.0001～5%.When extract directly uses extracting solution, as the drying solid composition if just passable in this scope.If in this scope, then can demonstrate and good whiten and/or prevent aging effect, and can obtain usability advantages of good skin external agent.
The combined amount of above-mentioned in the skin preparations for extenal use of this form (D2) composition, preferred 0.00001～5%, more preferably 0.0001～3%.When extract directly uses extracting solution, as the drying solid composition if just passable in this scope.If in this scope, then finding has better antioxidant effect, demonstrates good whiten and/or prevent aging effect, and can obtain usability advantages of good skin external agent.
The combined amount of above-mentioned in the skin preparations for extenal use of this form (E2) composition, preferred 0.00001～5%, more preferably 0.0001～3%.When plant extract directly uses extracting solution, as the drying solid composition if just passable in this scope.If in this scope, then finding has better anti-inflammatory effect, demonstrates good whiten and/or prevent aging effect, and can obtain usability advantages of good skin external agent.
The combined amount of above-mentioned in the skin preparations for extenal use of this form (F2) composition, preferred 0.00001～5%, more preferably 0.0001～3%.When extract directly uses extracting solution, as the drying solid composition if just passable in this scope.If in this scope, then find to have the better pachylosis effect of improving, demonstrate and good whiten and/or prevent aging effect, and can obtain usability advantages of good skin external agent.
The combined amount of above-mentioned in the skin preparations for extenal use of this form (G2) composition, preferred 0.001～25%, more preferably 0.01～20%.When extract directly uses extracting solution, as the drying solid composition if just passable in this scope.If in this scope, then finding has better moistening effect, demonstrates good whiten and/or prevent aging effect, and can obtain usability advantages of good skin external agent.
Skin preparations for extenal use of the present invention according to well-established law, can be blended in neccessary composition mentioned component (A) and above-mentioned (B) composition as common skin preparations for extenal use and modulate in the base of familiar all forms.
Example as the mixed style of skin preparations for extenal use, be not particularly limited, for example the cosmetics of any forms such as emulsion, cream, astringent, beauty and make-up cream, detergent, cosmetics, dispersion liquid, ointment, liquor, aerosol, alite paste, paste, liniment can, and topical drug etc. also can.
In addition, in skin preparations for extenal use of the present invention, except above-mentioned neccessary composition, normally used various compositions such as cosmetics and non-drug, topical drug, be water, alcohol, oil preparation, surfactant, viscosifier, powder body, chelating agen, pH adjustment agent, various drug effect agent, the extract that derives from the animals and plants microorganism, spice etc., in the scope that does not influence effect of the present invention, can suitably add.Wherein, concrete with following composition as example.
As in alcohol and the unduplicated scope of neccessary composition with dissolving, refrigerant, anticorrosion, to preserve moisture etc. be purpose, can use the multivalence alcohol of 1 valency such as ethanol and glycerol, 1,3 butylene glycol etc.
Oil preparation can use that to pay no attention to its source, the usability of character, usability good.For example Liquid Paraffin, three decanes, triglyceride oil, ester oil, wax class, fatty acid, higher alcohol, silicone oil, fluorine are oil, various waxes etc.
In order to be used for emulsifyings such as oil preparation and to dissolve etc., surfactant can use anionic property, cationic, nonionic and amphoteric surfactant.
As viscosifier, CVP Carbopol ETD2050, carrageenin, agar, xanthan gum, dextrin fatty acid ester, organo-clay mineral etc. derive from synthetic or natural product can use no matter be.These compositions not only can be used for such viscosity adjustment, can also be used for gelation, preserve moisture, form epithelium etc.
As powder body,,, also can carry out compoundization and surface treatment in order to improve usability and usability no matter shape and granular size have or not porous, crystalline texture.Can use inorganic particles such as Talcum, Muscovitum, sericite, anhydrous silicic acid according to purposes; Organic powders such as nylon cementitious matter; Particulate pigment such as light scale, bismuth oxychloride; Inorganic pigments such as ferrum oxide, white carbon black, ultramarine; Tar colorant and lake thereof, natural pigment, titanium oxide, particulate titanium dioxide, zinc oxide, particulate oxide zinc etc.Especially because when containing particulate titanium dioxide and particulate oxide zinc, can improve effect of the present invention more, so be preferred.
In order to prevent the quality badness of these compositions, also can make pH and adjust agent with buffer agents such as chelating agen such as EDTA, lactic acid-sodium lactates.
As the drug effect agent, can enumerate all compositions that contain vitamin, hormone, derive from the extract of animals and plants and microorganism.For example:
Antibacterial is in order to prevent, improve acne etc. and use, and can enumerate benzoic acid, sodium benzoate, para hydroxybenzene (first) acid esters, to first between chlorine (benzene) phenol, chlorination benzal hemlock, phenyl phenol, isopropyl cresol etc.Owing to mixed these compositions, can suppress the pigmentation that bacillary scytitis such as acne causes, and then performance is whitened more efficiently and/or skin Caring effect and prevent aging effect.
Active oxygen scavenger, in order to suppress to use, can enumerate superoxide dismutase, catechuic acid and derivant thereof, thiamine class (hydrochlorate thiamine, sulfate thiamine element), riboflavin class (riboflavin, acetic acid riboflavin etc.), pyridoxin class (Pyridoxin hydrochloride, pyrrole tremble dicaprylate etc.), nicotinic acid class vitamin(e) B groups such as (nicotiamide, nicotinic acid benzils etc.) by UV-induced generation lipid peroxide.Owing to mixed these active oxygen scavengers, it is gloomy to suppress face, and performance is whitened and/or skin Caring effect and prevent aging effect more efficiently.
And further improve effect of the present invention with other composition; can enumerate following composition, protein and derivant thereof or add the salt (collagen of water decomposition thing and they; elastoidin; keratin etc.); mucopolysaccharide and derivant (hyaluronic acid thereof; chondroitin sulfate etc.); aminoacid and derivant (histidine thereof; serine; glycine; theanine; aspartic acid; arginine; 2-pyrrolidone-5-carboxylic acid etc.); saccharide (Sorbitol; erithritol; trehalose; inositol; glucose; xylitol; sucrose and derivant thereof; dextrin and derivant thereof; Mel etc.); D-pantothenic acid alcohol and derivant thereof; glycolipid matter; acyl sphingosine; the angelica extract; the avocado extract; thermal water; the Althaea officinalis extract; the Herba lamii barbati extract; the radix ononidis extract; Oat Straw extract; Fructus Gardeniae extract; the Indocalanmus tessellatus extract; the Fructus Arctii extract; Semen Tritici aestivi extract; the Saponaria officinalis extract; Ramulus et Folium Spiraeae Salicifoliae extract; Rhizoma Zingiberis Recens extract; the West Herba Menthae (lavender) extract; Herba thymi vulgaris (Herba thymi vulgaris) extract; Camellia extract; upright committee mound Lay extract; the Apium graveolens extract; Folium Menthae extract; the Radix Hamamelidis Mollis extract; the Flos Rosae Multiflorae extract; the Japanese cypress extract; the sunflower extract; the Flos Caraganae Sinicae collection is plain; the Prune extract; Fructus Luffae extract; the bodhi tree extract; pine extract;
Quince extract, mucin, Centaurea cyanus extract, Garden lavender extract, Fructus Mali pumilae extract, Radix Gentianae extract etc.
Also have,, mix following oils and fats etc., can also bring into play higher whitening and/or the skin Caring effect, can expect to realize the skin (being the another name, Chinese herbal medicine name etc. of plant in the bracket) of transparent feel as the preparation that skin surface is had fine and closely woven effect.Jojoba oil, Macadamia nut oil, olive oil, almond oil (パ-シ Star Network oil), safflower oil, sunflower oil, avocado oil, Bai Manghua seed oil, Camellia oil, Oleum Armeniacae Dulcis, perilla oil, Oleum sesami, borage (Le リ ジ サ) oil, cocoa resin, Butyrospermum oils and fats.
The blood circulation promoting preparation is in order to promote skin blood circulation, promotes melanin to discharge and use, and can enumerate Fructus Capsici tincture, γ-Hi-Z etc., and ferment can be enumerated lipase, carase etc.These are mixed application can bring into play better whitening and/or the skin Caring effect.
Embodiment
Enumerate reference example, test example and embodiment below, the present invention will be described in more detail, but the present invention is not subjected to these any restrictions.
The manufacturing of [example 1] Cistus ladaniferus L. extract
With the leaf of Cistaceae plant Cistus ladaniferus L. and the ground product 20Kg of sprig, carry out vapor distillation, remove oil content.Then,, extract the extract that obtains and carry out distilling under reduced pressure, remove low boilers, obtain the extract 150g of solid-state～paste in normal hexane 200Kg.
[example 2] modulation laudanum acids and methyl ester and ethyl ester
Pure Labdanum (gum) (the lucky Potain system) 10g that sell in market, (0.1mmHg) carries out molecular distillation under reduced pressure, collects 180 ℃～220 ℃ fraction (4.3g).Chemical compound 1 (laudanum base-8-alkene-15-acid), chemical compound 4 (laudanum base-7-alkene-15-acid), chemical compound 7 (laudanum base-8 (17)-alkene-15-acid) (being called acid blend below this mixture) shown in below in this gold-plating divides, containing.1g is dissolved in the 2mL ether this acid blend, splashes into the Azimethylene. ethereal solution, obtains methyl ester 0.96g (being called mixtures of methyl esters below this methyl ester).Equally this acid blend 10g is dissolved in the 100mL ethanol, carries out esterification under the condition of sulfuric acid catalyst having, obtain ethyl ester 9.5g (being called the ethyl ester mixture below this ethyl ester).
Then, above-mentioned ethyl ester mixture is carried out silica gel chromatography, isolate three kinds of acid.Specifically be that 10g ethyl ester mixture is dissolved in the 100mL hexane, inject the silicagel column that silver nitrate was handled, the solvent that reinjects is separated out its dissolving.The solvent that injects at first is a hexane, then is the mixed solvent that has added the 1vol% ethyl acetate in hexane.Beginning is that chemical compound 3 (laudanum base-8-alkene-15-acetoacetic ester) dissolving is separated out, and then is that chemical compound 6 (laudanum base-7-alkene-15-acid) dissolving is separated out successively, and chemical compound 9 (laudanum base-8 (17)-alkene-15-acetoacetic ester) dissolving is separated out.From each lye, heat up in a steamer and desolvate, obtain each pure ethyl ester (0.83g, 0.16g, 0.63g) respectively.Ethyl ester obtaining adds water decomposition with well-established law, obtains free acid.In free acid, splash into the Azimethylene. ethereal solution again, solvent is heated up in a steamer, as the methyl ester agent.
Chemical compound 1
Chemical compound 2
Chemical compound 4
Chemical compound 5
Chemical compound 6
Ethyl ester mixture 4.3g example 2 obtains is dissolved in the 10mL ethanol, adds 5% palladium-carbon catalyst of 0.2g, carries out hydrogenation reaction, obtains 4.1g chemical compound 11.And then, add water decomposition, obtain chemical compound 10.
Chemical compound 7
Chemical compound 8
Chemical compound 9
Chemical compound 10
Chemical compound 11
[example 3] suppresses melanin generation and cells survival test with cell culture
Use is from the B16 melanoma cultured cell of house mouse.Get the MEM culture medium that contains 10%FBS in right amount on the plate in two 6 holes, sowing B16 melanoma cell is statically placed in the carbon dioxide of 5vol% under 37 ℃ of conditions.Added and the composite sample modulating liquid in second day, laudanum acids and methyl ester and ethyl ester that Cistusladaniferus L. extract that example 1 obtains and example 2 are obtained, ultimate density are that 0 (contrast), 5,10 μ g/mL, the white Bulbus Lilii extract of whitening agent (ball is apt to drugmaker's system) are 0,100 μ g/mL.Change culture medium when the 5th day that cultivates, add the sample modulating liquid once again.Removed culture medium again at second day, behind a plate usefulness phosphate buffer (pH7) cleaning cell, reclaim,, estimate by following standard to the whitening degree of B16 melanoma cultured cell.
In addition, as a comparative example, there is the Semen Coicis extract (100 μ g/mL) that suppresses melanin generation effect also to carry out same test for knowing.
Semen Coicis extract is the 70vol% aquiferous ethanol of adding 100mL in 10g Semen Coicis (day office), at room temperature extract 3 days after, obtain after filtration.At this moment, the dry solid-state part of Semen Coicis extract is 0.8%.
(criterion)
++: compare with tester, for extremely white.
+: compare with tester, be evident as white.
±: comparing with tester, is white slightly.
-: compare with tester, be similarly black.
For a remaining plate, with formalin cell fixation after, add 1% aldrich mixture dyeing.With the cells survival rate of single-layer culturing cell densimeter (Olympus (ォ リ Application バ ス) corporate system) mensuration corresponding to each reagent concentration.Top result is shown in table 1-1.
Table 1-1 (result)
| Test portion ultimate density (μ g/mL) | White Bulbus Lilii extract adds concentration (μ g/mL) | The whitening degree | Cells survival rate (%) | |
| Cistus ladaniferus L extract *1 | 10 | 100 | ++ | 105 |
| Acid blend *2 | 5 | 100 | ++ | 120 |
| Mixtures of methyl esters *2 | 5 | 100 | ++ | 98 |
| The ethyl ester mixture *2 | 5 | 100 | ++ | 89 |
| Chemical compound 1 *2 | 5 | 100 | ++ | 92 |
| Chemical compound 4 *2 | 5 | 100 | ++ | 94 |
| Chemical compound 7 *2 | 5 | 100 | ++ | 95 |
| Semen Coicis extract *3 | 100 | 100 | ++ | 94 |
| Cistus ladaniferus L extract *1 | 20 | 0 | + | 100 |
| Acid blend *2 | 10 | 0 | + | 92 |
| Mixtures of methyl esters *2 | 10 | 0 | + | 90 |
| The ethyl ester mixture *2 | 10 | 0 | + | 90 |
| Chemical compound 1 *2 | 10 | 0 | + | 94 |
| Chemical compound 4 *2 | 10 | 0 | + | 93 |
| Chemical compound 7 *2 | 10 | 0 | + | 98 |
| Semen Coicis extract *3 | 200 | 0 | ± | 100 |
| White Bulbus Lilii extract *4 | 0 | 200 | ± | 100 |
*Make in 1 example 1
*Make in 2 examples 2
*Make in 3 examples 3
*The kind drugmaker of 4 balls system
As the result from table 1-1 learns, Cistus ladaniferus L. extract and laudanum acids and methyl ester and ethyl ester, even independent also having suppresses to produce melanic function, and for a little less than the B16 melanoma cultured cell toxicity.Owing to further and with the white Bulbus Lilii extract of whitening agent, relatively, obtained the reinforced effects of whitening during with individual processing.So Cistus ladaniferus L. extract and laudanum acids and methyl ester thereof and ethyl ester and white Bulbus Lilii extract collocation, be applied to skin, brought into play the effect that extremely good inhibition melanin produces, can expect that its skin darkening that effectively suppresses Exposure to Sunlight and cause, brown patch, freckle etc. whiten and the skin Caring effect.
[example 4: emulsifiable paste]
The various emulsifiable pastes of composition shown in the table 2-1 have been modulated.
At first, blending constituent (1)～(6) and (12), heating, in remaining in 70 ℃ mixture, add remain on 70 ℃ composition (16).And then, mixed composition (7)～(11) and (13)～(15) again after, cooling obtains emulsifiable paste.
For the various emulsifiable pastes that obtain,, whiten and the investigation of skin Caring effect with following test method.(test method)
Respectively every kind of test portion emulsifiable paste is formed panel by 27～54 years old 15 of women, estimates, every morning and evening twice after washing one's face, smear an amount of test emulsifiable paste on the face, 12 weeks on probation, by following standard evaluation whiten and the skin Caring effect.Evaluation result is represented with each number of estimating panel.
(evaluation criterion)
＜estimate＜content 〉
Gloomy obvious disappearance of effective skin.
Slightly effectively skin is gloomy not too obvious.
Invalid do not have to change with use is preceding.
As show shown in the result of 2-1, with product relatively relatively with all compositions (composition (8)～(13)) of Cistus ladaniferus L. extract and (B) of the present invention composition and the present invention's product emulsifiable paste of usefulness, be used for skin, can more effectively prevent, improve the gloomy of skin, reach the effect of skin Caring.[example 5 usefulness cell culture carry out the cell-stimulating test]
Use neonatal fibroblast NB1RGB.Get an amount of culture medium on 24 orifice plates, sowing fibroblast NB1RGB under 37 ℃ of conditions, is statically placed in the carbon dioxide that concentration is 5vol%.Second day, add the mix reagent modulating liquid, making the laudanum acids that obtains in the Cistus ladaniferus L. extract that obtains in the example 1, the example 2 and the ultimate density of methyl ester and ethyl ester thereof is 0 (contrast), 5,10 μ g/mL; Cell activator Radix Dauci Sativae extract (the kind drugmaker of ball system) is 0,100 μ g/mL.Changed culture medium, and added the reagent modulating liquid once again in the 4th day that cultivates.Second day, remove culture medium, after cell is cleaned with phosphate buffer, reclaim, the cell number of the fibroblast NB1RGB that breeds in each reagent modulating liquid is compared, the cell proliferation rate after is estimated as a comparison.
In addition, as a comparative example,, also carried out same test for knowing the soybean extract (100 μ g/mL) that the cell-stimulating effect is arranged.Soybean extract is in the 10g soybean seed, adds the aquiferous ethanol 100mL of 70vol%, after at room temperature carrying out extracting in 3 days, obtains after filtration.At this moment the dry solid state component of soybean extract is 0.5%.
(evaluation criterion)
Add all ingredients and adjust liquid, the cell number of the cell number of breeding and contrast relatively, its cell proliferation rate as index, has been estimated the cell-stimulating effect.Calculated cell number with the hemocytometer abacus again.
Table 3-1 (result)
| Test portion adds concentration (μ g/mL) | Radix Dauci Sativae extract adds concentration (μ g/ mL) | Cell-stimulating rate (%) | |
| Cistus ladaniferus L. extract *1 | 10 | 100 | 250 |
| Acid blend *2 | 5 | 100 | 320 |
| Mixtures of methyl esters *2 | 5 | 100 | 310 |
| The ethyl ester mixture *2 | 5 | 100 | 345 |
| Chemical compound 1 *2 | 5 | 100 | 329 |
| Chemical compound 4 *2 | 5 | 100 | 322 |
| Chemical compound 7 *2 | 5 | 100 | 333 |
| Soybean extract *3 | 100 | 100 | 170 |
| Cistus ladaniferus L. extract *1 | 20 | 0 | 120 |
| Acid blend *2 | 10 | 0 | 130 |
| Mixtures of methyl esters *2 | 10 | 0 | 125 |
| The ethyl ester mixture *2 | 10 | 0 | 135 |
| Chemical compound 1 *2 | 10 | 0 | 128 |
| Chemical compound 4 *2 | 10 | 0 | 130 |
| Chemical compound 7 *2 | 10 | 0 | 135 |
| Soybean extract *3 | 200 | 0 | 108 |
| Radix Dauci Sativae extract *4 | 0 | 200 | 110 |
*Make in 1 example 1
*Make in 2 examples 2
*Make in 3 examples 5
*The kind drugmaker of 4 balls system
As the result who shows 3-1 shows, confirm that this plant extract has the cell-stimulating ability to neonatal fibroblast NB1RGB.When with cell activator Radix Dauci Sativae extract and time spent, stronger cell-stimulating ability is arranged.Therefore, because cell activator of the present invention is Cistus ladaniferus L. extract and laudanum acids and methyl ester thereof and ethyl ester and Radix Dauci Sativae extract to be arranged in pairs or groups be used for skin, so brought into play extremely good aging resistance effect, expect its can effectively improve because of old, be exposed to wrinkle of skin that ultraviolet etc. produces, Dermatochalasia etc.
[example 6: emulsifiable paste]
Modulated the emulsifiable paste of composition shown in the table 4-1 respectively.
At first, composition (1)～(6) and (10) mix, heating, in remaining in 70 ℃ mixture, add heating and remain on the part of 70 ℃ composition (15).Composition (7)～(9) and (11)～(14) are mixed in wherein, and cooling obtains emulsifiable paste then.
For the various emulsifiable pastes that obtain, improve the effect of wrinkle with following test method investigation.
*Make in 1 example 1
*2 Sigma's corporate systems
*The kind drugmaker of 3 balls system
*4 BASF AG's systems
*5 Japanese Roche corporate systems
*The kind drugmaker of 6 balls system
(test method)
To every kind of test portion emulsifiable paste, form panel by 20 of 35～59 years old women respectively, every day, morning and evening twice, an amount of emulsifiable paste is smeared on the face in the back that washes one's face, and uses for 12 weeks.Improve the effect of wrinkle after smearing by following standard evaluation.
(evaluation criterion)
＜estimate＜content 〉
Effectively the wrinkle of skin has obviously disappeared.
Slightly effectively the wrinkle of skin becomes not too obvious.
Invalid do not have to change with use is preceding.
Shown in the result of table 4-1, learn with product relatively and compare that the Cistus ladaniferus L. extract and (B) emulsifiable paste of the present invention of various compositions of composition and usefulness are used for skin, can improve " wrinkle " of skin etc., become resilient beautiful skin.
[example 7: the agent of washing one's face]
Following composition (1)～(10) heating is mixed, remain on 70 ℃.It is cooled to room temperature, adds and mix (11)～(16), and obtain to wash one's face agent.
(composition) (%)
(1) N-coco-nut oil fatty acid acyl group-L-glutamic acid triethanolamine 20.0
(2) lauryl decil acid betanin 10.0
(3) cocoanut fatty acid diethanolamide 3.0
(4) coco-nut oil fatty acid potassium 5.0
(5) stearic acid 2.0
(6) glycerol 20.0
(7) PEG400 5.0
(8) erithritol 2.0
(9) propylene glycol 10.0
(10) antiseptic is an amount of
(11) spice is an amount of
(12) Cistus ladaniferus L. extract
*1 1.0
(13) Aloe extract
*2 0.02
(14) chamomile extract
*3 0.02
(15) Rhizoma Chuanxiong extract
*4 0.02
(16) distilled water surplus
*Make in 1 example 1
*The kind drugmaker of 2 balls system
*The kind drugmaker of 3 balls system
*The kind drugmaker of 4 balls system
The agent of washing one's face that obtains is the agent of washing one's face of stability skin Caring lasting, that be used for having on the skin transparent feel.
[example 8: emulsion]
Following composition (1)～(8) heating is mixed to 70 ℃.In this mixture, add being blended in heat under 70 ℃ of conditions blended (9)～(13) and (22),, add again and mix (14) and (15)～(21), and obtain emulsion its cooling.
(composition) (%)
(1) Lecinol S-10EX 3.0
(2) cholesterol 0.2
(3) polyethylene glycol oxide (5) cetyl ether 0.2
(4) polyethylene glycol oxide (10) sclerosis castor bean oil 1.0
(5) cetostearyl alcohol 2.0
(6) olive oil three decanes 5.0
(7) dipropylene glycol 7.0
(8) 1,3 butylene glycol 5.0
(9) L-serine
*1 0.2
(10) pyrrolidone sodium carboxylate
*2 0.1
(11) the trimethyl aminoacetic acid 2.0
(12) hydroxypropyl methylcellulose 0.1
(13) CVP Carbopol ETD2050 0.2
(14) potassium hydroxide 0.1
(15) antiseptic is an amount of
(16) spice is an amount of
(17) Cistus ladaniferus L. extract
*3 0.1
(18) Cydonia oblonga seed extracts
*4 5.0
(19) Semen Armeniacae Amarum extract
*5 0.2
(20) yeast extract
*6 0.2
(21) Radix althaeae roseae extract
*7 0.2
(22) distilled water surplus
*1 gourmet powder corporate system
*2 gourmet powder corporate systems
*Make in 3 examples 1
*4 fragrant Rong Xingye corporate systems
*5 LABORATOIRES SEROBIOLOGIQUES corporate systems
*The kind drugmaker of 6 balls system
*The kind drugmaker of 7 balls system
[example 9: emulsion]
Following composition (13)～(17) heating mixing is remained on 70 ℃.In this mixture, add same heating blended composition (1)～(12) and carry out emulsifying.After its cooling, add composition (18)～(25) again, uniform mixing and obtain emulsion.
(composition) (%)
(1) sorbitan single-stearic hydrochlorate 0.3
(2) single oleic acid polyethylene glycol oxide (20) sorbitan 0.1
(3) lipophilic glycerol-stearate 0.2
(4) stearic acid 0.5
(5) spermol 0.5
(6) three decanes 3.0
(7) Liquid Paraffin 4.0
(8) three-2 ethyl hexanoic acid glycerol 2.0
(9) dimethyl polysiloxane 1.0
(10) Lecinol S-10EX 0.1
(11) acetic acid-dl-alpha-tocopherol
*1 0.05
(12) antiseptic is an amount of
(13) CVP Carbopol ETD2050 0.1
(14) sodium hydroxide 0.05
(15) glycerol 5.0
(16) 1,3 butylene glycol 7.0
(17) distilled water surplus
(18) ethanol 5.0
(19) Cistus ladaniferus L. extract
*2 0.05
(20) Herba Saxifragae extract
*3 0.1
(21) rose hip extract
*4 0.1
(22) Radix Sophorae Flavescentis extract
*5 0.1
(23) coffee-extract
*6 0.1
(24) Cordyceps extract
*7 0.1
(25) spice is an amount of
*1 エ-ザ イ corporate system
*Make in 2 examples 1
*3 one ball Off ア Le コ ス corporate systems
*The kind drugmaker of 4 balls system
*The kind drugmaker of 5 balls system
*6-ball Off ア コ ス corporate system
*The kind drugmaker of 7 balls system
[example 10: gel cosmetic products]
Following composition (1)～(5) and (19) heating are mixed, be cooled to room temperature.In this mixture, add being blended in blended (6)～(10) of heating under 70 ℃ of conditions, and then, add again and mix (11)～(18) and the acquisition gel cosmetic products.
(composition) (%)
(1) methylcellulose 2.0
(2) xanthan gum 1.0
(3) sodium alginate 0.2
(4) alkyl-modified carboxylation ethene polymers 0.2
(5) hyaluronate sodium 1% aqueous solution 2.0
(6) glycerol 10.0
(7) Macrogol 2000 0 1.0
(8) methyl glucoside 2.0
(9) the hydrogenation egg yolk lecithin 0.2
(10) plant sterol 0.1
(11) sodium hydroxide 0.1
(12) antiseptic is an amount of
(13) spice is an amount of
(14) Cistus ladaniferus L. extract
*1 0.001
(15) oolong tea extract
*2 0.3
(16) senna extract
*3 0.3
(17) Salvia farinacea extract
*4 0.3
(18) Radix Malvae sylvestris extract
*5 0.3
(19) distilled water surplus
*Make in 1 example 1
*The kind drugmaker of 2 balls system
*The kind drugmaker of 3 balls system
*The kind drugmaker of 4 balls system
*The kind drugmaker of 5 balls system
[example 11: oleogel cosmetics]
Mixing is heated in following composition (1)～(9) under 70 ℃ of conditions, be cooled to room temperature.In this mixture, add and mix (10) and (21), and then interpolation mixes (11)～(20) and obtains the oleogel cosmetics again.
(composition) (%)
(1) polyethylene glycol oxide (20) polypropylene oxide (4) cetyl ether 1.0
(2) polyethylene glycol oxide (20) three isostearic acid glyceryls 0.2
(3) alkyl-modified carboxylation ethene polymers 0.2
(4) glycerol 10.0
(5) dipropylene glycol 2.0
(6) 1,3 butylene glycol 5.0
(7) polyethylene glycol oxide (10) methyl glucoside 0.2
(8) three-2 ethyl hexanoic acid glyceryls 75.0
(9) three decanes 2.0
(10) triethanolamine 0.1
(11) antiseptic is an amount of
(12) spice is an amount of
(13) glycyrrhizic acid stearoyl
*1 0.1
(14) Cistus ladaniferus L. extract
*2 0.005
(15) beta-carotene
*3 0.002
(16) safflower oil
*4 1.0
(17) peach kernel oil
*5 1.0
(18) nicotinic acid-dl-alpha-tocopherol
*6 0.1
(19) Palmic acid retinal
*7 0.3
(20) dibenzylatiooluene
*8 0.002
(21) distilled water surplus
*The kind drugmaker of 1 ball system
*Make in 2 examples 1
*3 Sigma's corporate systems
*4 gourmet powder corporate systems
*5 ENNAGRAM corporate systems
*6 エ-ザ イ corporate system
*7 Japanese Russell Co., Ltd systems
*8 Sigma's corporate systems
[example 12: astringent]
The mixture behind following composition (1)～(9) and (12), (17) mixed dissolution, add the mixture behind composition (10), (11), (13)～(16) and (18)～(24) mixed dissolution, mix astringent.
(composition) (%)
(1) Macadamia nut oil 0.01
(2) borage grass oil 0.01
(3) sad cetyl 0.01
(4) three-2 ethyl hexanoic acid glyceryls 0.01
(5) acetic acid-dl-alpha-tocopherol
*1 0.02
(6) sesquialter oleic acid sorbitan 0.1
(7) single oleic acid polyethylene glycol oxide (20) sorbitan 0.1
(8) polyethylene glycol oxide (8) alkyl ether phosphoric acid 0.2
(9) ethanol 10.0
(10) Sorbitol (70% aqueous solution) 5.0
(11) glycerol 1.0
(12) 2-hydroxyl-4-methoxy benzophenone
*2 0.2
(13) 2-hydroxyl-4-methoxy benzophenone-5-sodium sulfonate
*3 0.2
(14) lactic acid (50% aqueous solution) 0.1
(15) sodium lactate (50% aqueous solution) 0.3
(16) antiseptic is an amount of
(17) spice is an amount of
(18) Cistus ladaniferus L. extract
*4 0.01
(19) glycyrrhizic acid dipotassium
*5 0.1
(20) white Bulbus Lilii extract
*6 0.05
(21) Folium perillae extract
*7 0.05
(22) rasp berry extract
*8 0.05
(23) chesnut extract
*9 0.05
(24) distilled water surplus
*1 エ-ザ イ corporate system
*2 common drug company systems
*South, 3 Hunan chemical industrial company system
*Make in 4 examples 1
*The kind drugmaker of 5 balls system
*The kind drugmaker of 6 balls system
*The kind drugmaker of 7 balls system
*8 エ ス ペ リ ス corporate systems
*The kind drugmaker of 9 balls system
[example 13: astringent]
The mixture behind composition (1)～(9) mixed dissolution, the mixture behind the mixed dissolution of adding (10)～(20) mixes and the acquisition astringent.
(composition) (%)
(1) the gamma-linoleic acid sucrose ester 0.05
(2) single isostearic acid polyethylene glycol oxide (50) sclerosis castor bean oil 1.0
(3) different Palmic acid L-ascorbic acid 0.1
(4) polyethylene glycol oxide (10) alkyl ether phosphoric acid 0.1
(5) methoxyl group cinnamic acid octyl group
*1 0.05
(6) glycerol 3.0
(7) N-acetyl group-L-glutamic acid
*2 0.1
(8) 1,3 butylene glycol 5.0
(9) ethanol 8.0
(10) sodium citrate 0.02
(11) citric acid 0.05
(12) antiseptic is an amount of
(13) spice is an amount of
(14) Cistus ladaniferus L. extract
*3 0.05
(15) Herba Centellae extract
*4 0.2
(16) Semen Ginkgo extrac
*5 0.2
(17) extract of Fagus sinensis Oliv. bud
*6 0.05
(18) sweet tea extract
*7 0.05
(19) Herba Erodii extract
*8 0.05
(20) distilled water surplus
*1 BASF AG's system
*2 synergisms fermentation corporate system
*Make in 3 examples 1
*The kind drugmaker of 4 balls system
*5 normal huge rock fitochemical studies institute corporate systems
*6 ガ テ ホ セ corporate systems
*The kind drugmaker of 7 balls system
*The kind drugmaker of 8 balls system
[example 14: nebulousurine astringent]
The mixture behind following composition (1)～(10) mixed dissolution, add in composition (11)～(21) be mixed in behind the mixed dissolution, and obtain the astringent of nebulousurine.
(composition) (%)
(1) polyethylene glycol oxide (60) sclerosis castor bean oil 0.7
(2) the polyethylene oxide alkyl ethers sodium phosphate 0.2
(3) cholesterol 0.01
(4) the hydrogenation egg yolk lecithin 0.02
(5) dimethyl polysiloxane 0.05
(6) acetic acid-dl-alpha-tocopherol
*1 0.5
(7) p-methoxycinnamate 2-ethylhexyl
*2 0.2
(8) enoxolone stearoyl
*3 0.1
(9) ethanol 15.5
(10) polyethylene glycol 6000 0.2
(11) citric acid 0.01
(12) phosphoric acid one disodium hydrogen 0.2
(13) rutin
*4 0.01
(14) antiseptic is an amount of
(15) spice is an amount of
(16) Cistus ladaniferus L. extract
*5 0.002
(17) hydroxyproline
*6 0.01
(18) Nasturtium officinale extract
*7 0.1
(19) coltsfoot extract
*8 0.1
(20) lactobacillus extract
*9 0.1
(21) distilled water surplus
*1 エ-ザ イ corporate system
*2 BASF AG's systems
*The kind drugmaker of 3 balls system
*4 Sigma's corporate systems
*Make in 5 examples 1
*6 consonance fermentation corporate systems
*7 A.M.I corporate systems
*The kind drugmaker of 8 balls system
*9 longevity chemical company's systems
[example 15: beautifying liquid]
In composition (1)～(4) of mixed dissolution under 50 ℃ of conditions, the mixture of (6) and (7) heats under 50 ℃ of conditions with composition (8)～(13), (25) and mixes, be cooled to the mixture after the room temperature, add blending constituent (5), (14)～(24) again, obtain sticking beautifying liquid.
(composition) (%)
(1) isostearic acid polyethylene glycol oxide (50) sclerosis castor bean oil 0.2
(2) Lecinol S-10EX 0.5
(3) glycerol 7.0
(4) dl-alpha-tocopherol
*1 0.3
(5) Radix Angelicae Sinensis extract
*2 0.2
(6) cholesterol 0.1
(7) ethanol 6.0
(8) 2-hydroxyl-4-methoxy benzophenone-5-sodium sulfonate
*3 0.2
(9) the L-magnesium ascorbyl phosphate 0.5
(10) citric acid 0.01
(11) sodium citrate 0.1
(12) xanthan gum 0.1
(13) methylcellulose 0.1
(14) Sargassum extract
*4 0.1
(15) Cortex Acanthopancis extract
*5 0.1
(16) wheat malt germ extract
*6 0.1
(17) Radix Paeoniae Alba extract
*7 0.1
(18) nicotiamide
*8 0.05
(19) yellow tiller extract
*9 0.1
(20) Fructus Lycopersici esculenti extract
*10 0.1
(21) Cortex Mori extract
*11 0.1
(22) antiseptic is an amount of
(23) spice is an amount of
(24) Cistus ladaniferus L. extract
*12 1.0
(25) distilled water surplus
*1 エ-ザ イ corporate system
*2 Japanese powder pharmaceutical corporate systems
*South, 3 Hunan chemical industrial company system
*The kind drugmaker of 4 balls system
*The kind drugmaker of 5 balls system
*6 one-tenth and change into corporate system
*7 Dao field spice corporate systems
*8 and the pure medicine corporate system of light
*The kind drugmaker of 9 balls system
*10 ェ ス ペ リ ス corporate systems
*The kind drugmaker of 11 balls system
*Make in 12 examples 1
[example 16: ultra light sun block lotion]
Heating mixes in 70 ℃ of following compositions of condition (1)～(10), makes it be separated into pulpous state.Dissolving mixed composition (11)～(13) and (15)～(22) under 50 ℃ of conditions are blended in this, adding ingredient (14) again, and obtain ultra light sun block lotion.
(composition) (%)
(1) two capric acid neopentyl ethylene glycol 10.0
(2) p-methoxycinnamate-2-ethylhexyl
*1 5.0
(3) octamethylcy-clotetrasiloxane 10.0
(4) decamethylcyclopentasiloxane 10.0
(5) dimethyl polysiloxane 5.0
(6) particulate titanium dioxide 10.0
(7) particulate oxide zinc 5.0
(8) polyalkylene modified organic silicon oxygen alkane 5.0
(9) nylon powder 2.0
(10) the polyethylene end 1.0
(11) glycerol 5.0
(12) ethanol 5.0
(13) antiseptic is an amount of
(14) spice is an amount of
(15) Cistus ladaniferus L. extract
*2 0.2
(16) glycyrrhizic acid dipotassium
*3 0.1
(17) Cortex Mori extract
*4 0.1
(18) Flos Rosae Rugosae extract
*5 0.01
(19) green tea extract
*6 0.01
(20) Herba leucadis ciliatae extract
*7 0.01
(21) Radix Gentianae extract
*8 0.01
(22) distilled water surplus
*1 BASF AG's system
*Make in 2 examples 1
*The kind drugmaker of 3 balls system
*The kind drugmaker of 4 balls system
*The kind drugmaker of 5 balls system
*The kind drugmaker of 6 balls system
*The kind drugmaker of 7 balls system
*The kind drugmaker of 8 balls system
[example 17: water-in-oil type sunscreen frost]
Under 70 ℃ of conditions, composition (1)～(9) heating is mixed.Heat under 50 ℃ of conditions mixed composition (10)～(13) and (15)～(20) are made an addition to this, and adding ingredient (14) obtains the water-in-oil type sunscreen frost again.
(composition) (%)
(1) polyalkylene modified organic silicon oxygen alkane 2.0
(2) the Palmic acid octyl group 15.0
(3) decamethylcyclopentasiloxane 20.0
(4) San behenic acid glyceryls 1.0
(5) particulate oxide zinc 12.0
(6) particulate titanium dioxide 3.0
(7) p-methoxycinnamate-2-ethylhexyl
*1 7.0
(8) the 4-tert-butyl group-4 '-methoxyl group DBM
*2 1.0
(9) perilla oil
*3 0.05
(10) dipropylene glycol 5.0
(11) ethanol 5.0
(12) the polyethylene end 3.0
(13) antiseptic is an amount of
(14) spice is an amount of
(15) Cistus ladaniferus L. extract
*4 0.2
(16) Betula platyphylla Suk. extract
*5 0.2
(17) biennial wormwood extract
*6 0.2
(18) mannitol
*7 0.05
(19) Citrus auantium peel extract
*8 0.2
(20) distilled water surplus
*1 BASF AG's system
*2 lucky Potain systems
*Make in 3 examples 1
*The kind drugmaker of 4 balls system
*The kind drugmaker of 5 balls system
*6 and the pure medicine corporate system of light
*7 and the pure medicine corporate system of light
*The kind drugmaker of 8 balls system
[example 18: water-in-oil type emulsifiable paste]
Under 70 ℃ of conditions, composition (1)～(8) heating is mixed, heat under 50 ℃ of conditions mixed composition (9)～(16) and (18)～(25) are made an addition to this, adding ingredient (17) obtains the water-in-oil type emulsifiable paste again.
(composition) (%)
(1) the hydrogenation soybean phospholipid 0.05
(2) polyoxyalkylene modified organic silicon oxygen alkane 2.0
(3) the hydroxy stearic acid cholesterol 2.0
(4) cholesterol 0.2
(5) three decanes 2.0
(6) decamethylcyclopentasiloxane 7.0
(7) two isooctyl acid ethylene glycol 15.0
(8) 2-hydroxyl-4-methoxy benzophenone-5-sulfonic acid
*1 1.0
(9) the L-magnesium ascorbyl phosphate 3.0
(10) sodium citrate 0.5
(11) disodium edetate 0.05
(12) ethanol 2.0
(13) 1,3 butylene glycol 5.0
(14) crystalline cellulose 2.0
(15) spherical nylon end 1.0
(16) antiseptic is an amount of
(17) spice is an amount of
(18) Cistus ladaniferus L. extract
*2 0.3
(19) molasses extract
*3 0.1
(20) Flos lupuli (Flos Humuli Lupuli) extract
*4 0.1
(21) arnica montana extract
*5 0.1
(22) Fructus Hordei Vulgaris extract
*6 0.1
(23) Semen Armeniacae Amarum extract
*7 0.1
(24) Rhizoma Acori Graminei extract
*8 0.1
(25) distilled water surplus
*1 バ デ ィ Star シ ユ corporate system
*Make in 2 examples 1
*3 sun Chemical Corporation's systems
*The kind drugmaker of 4 balls system
*The kind drugmaker of 5 balls system
*6 three province drugmaker systems
*7 エ ス ペ リ corporate systems
*The kind drugmaker of 8 balls system
[example 19: emulsifiable paste]
Under 70 ℃ of conditions, following composition (1)～(10) heating is mixed, mixed composition (11)～(13) of heating under 70 ℃ of conditions, (24) and (27) interpolation are mixed in this mixture, add blending constituent (14)～(23), (25) and (26) again, be cooled to room temperature, obtain emulsifiable paste.
(composition) (%)
(1) cetostearyl alcohol 3.0
(2) fatty acid glyceride 2.0
(3) single oleic acid polyethylene glycol oxide (20) sorbitan 1.0
(4) sorbitan single-stearic hydrochlorate 1.0
(5) N-stearoyl-N-methylamino ethyl sulfonic acid sodium 0.5
(6) vaseline 5.0
(7) dimethyl polysiloxane 3.0
(8) three-2 ethyl hexanoic acid glyceryls 20.0
(9) dl-alpha-tocopherol
*1 1.0
(10) titanium oxide 1.0
(11) dipropylene glycol 10.0
(12) the L-magnesium ascorbyl phosphate 3.0
(13) sodium citrate 0.5
(14) glycyrrhizic acid dipotassium
*2 0.1
(15) lactic acid (50% aqueous solution) 0.1
(16) Radix Dauci Sativae extract
*3 0.1
(17) Herba Asari extract
*4 0.3
(18) crab apple extract
*5 0.02
(19) Flos Lonicerae extract
*6 0.02
(20) pollen extract of Herba Typhae
*7 0.02
(21) soybean extract
*8 0.02
(22) Radix Angelicae Sinensis extract
*9 0.02
(23) disodium edetate 0.03
(24) antiseptic is an amount of
(25) spice is an amount of
(26) Cistus ladaniferus L. extract
*10 0.5
(27) distilled water surplus
*1 エ-ザ イ corporate system
*The kind drugmaker of 2 balls system
*3 one ball Off ア Le コ ス corporate systems
*The kind drugmaker of 4 balls system
*The kind drugmaker of 5 balls system
*6 Changgong spice corporate systems
*The kind drugmaker of 7 balls system
*8 fragrant Rong Xingye corporate systems
*9 Japanese powder pharmaceutical corporate systems
*Make in 10 examples 1
[example 20: beauty cream]
Under 70 ℃ of conditions, following composition (1)～(5) and (23) heating is mixed, be cooled in the mixture after the room temperature, add blending constituent (6)～(22), obtain beauty cream.
(composition) (%)
(1) polyvinyl alcohol 15.0
(2) glycerol 10.0
(3) polyethylene glycol oxide (10) methyl glucoside 3.0
(4) three sad glyceryls 5.0
(5) the polyethylene oxide alkyl ethers sodium phosphate 1.0
(6) ethanol 20.0
(7) potter's clay 2.0
(8) titanium oxide 2.0
(9) Sargassum extract
*1 0.1
(10) glycyrrhizic acid dipotassium
*2 0.1
(11) wheat malt germ extract
*3 0.1
(12) Fructus Chaenomelis extract
*4 0.1
(13) Testa oryzae extract
*5 0.01
(14) Herba Hyperici Erecti extract
*6 0.01
(15) rasp berry extract
*7 0.01
(16) Rhizoma Acori Graminei extract
*8 0.01
(17) Radix Rehmanniae extract
*9 0.01
(18) lactic acid (50% aqueous solution) 0.5
(19) sodium lactate (50% aqueous solution) 0.5
(20) antiseptic is an amount of
(21) spice is an amount of
(22) Cistus ladaniferus L. extract
*10 0.02
(23) distilled water surplus
*The kind drugmaker of 1 ball system
*The kind drugmaker of 2 balls system
*3 one-tenth and change into corporate system
*The kind drugmaker of 4 balls system
*5 fragrant Rong Xingye corporate systems
*The kind drugmaker of 6 balls system
*7 エ ス ペ リ ス corporate systems
*The kind drugmaker of 8 balls system
*9 fragrant Rong Xingye corporate systems
*Make in 10 examples 1
[example 21: liquid foundation cream]
Following composition (1)～(7) heating is mixed, in this mixture, add composition (13)～(18), remain on 70 ℃.Mixing composition (8)～(12), remaining in 70 ℃ the mixture, adding the mixture of front, and make its uniformly emulsify.After the cooling, adding ingredient (19)～(25) obtain liquid foundation cream.
(composition) (%)
(1) the dipentaerythritol fatty acid ester 2.0
(2) Liquid Paraffin 5.0
(3) stearic acid 2.0
(4) spermol 1.0
(5) the self-emulsifying type monostearin 1.0
(6) p-methoxycinnamate-2-ethylhexyl 8.0
(7) antiseptic is an amount of
(8) glycerol 5.0
(9) triethanolamine 1.0
(10) carboxymethyl cellulose 0.5
(11) bentonite 0.2
(12) distilled water surplus
(13) titanium oxide 6.0
(14) particulate titanium dioxide 2.0
(15) particulate oxide zinc 4.0
(16) Muscovitum 2.0
(17) Talcum 4.0
(18) coloring pigment is an amount of
(19) Cistus ladaniferus L. extract
*1 0.01
(20) Radix Scutellariae extract
*2 0.1
(21) peony extract
*3 0.1
(22) daisy extract
*4 0.1
(23) Ramulus Sambuci Williamsii extract
*5 0.1
(24) Fructus Sapindi Mukouossi extract
*6 0.1
(25) spice is an amount of
*Make in 1 example 1
*2 one ball Off ア Le コ ス corporate systems
*3 one ball Off ア Le コ ス corporate systems
*4 one ball Off ア Le コ ス corporate systems
*5 セ ペ Star Network ス corporate systems
*6 fragrant Rong Xingye corporate systems
The various cosmetics that obtained by example 8～21 all are to have lasting stability, being used for skin to preventing and improving the respond well of the gloomy skin, brown patch and the freckle that are caused by Exposure to Sunlight and old wrinkle that causes and Dermatochalasia, is the various skin Caring cosmetics that transparent feel is arranged.
[example 22] utilizes cell culture to suppress melanin generation and the test of cells survival rate
Use is from the B16 melanoma cultured cell of house mouse.On two 6 orifice plates, get the MEM culture medium that contains 10% FBS in right amount, sowing B16 melanoma cell under 37 ℃ of conditions, is statically placed in the carbon dioxide that concentration is 5vo1%.Added and the composite sample modulating liquid in second day, laudanum acids and methyl ester and ethyl ester that Cistusladaniferus L. extract that example 1 obtains and example 2 are obtained, ultimate density are that 0 (contrast), 5,10 μ g/mL, the white Bulbus Lilii extract of whitening agent (ball is apt to drugmaker's system) are 0,100 μ g/mL.Change culture medium when the 5th day that cultivates, add the sample modulating liquid once again.Removed culture medium again at second day, behind a plate usefulness phosphate buffer (pH7) cleaning cell, reclaim,, estimate by following standard to the whitening degree of B16 melanoma cultured cell.
In addition, as a comparative example, there is the Semen Coicis extract (100 μ g/mL) that suppresses melanin generation effect also to carry out same test for knowing.
Semen Coicis extract is the 70vol% aquiferous ethanol of adding 100mL in 10g Semen Coicis (day office), at room temperature extract 3 days after, obtain after filtration.At this moment, the dry solid-state part of Semen Coicis extract is 0.8%.
(criterion)
++: compare with tester, for extremely white.
+: compare with tester, be evident as white.
±: comparing with tester, is white slightly.
-: compare with tester, be similarly black.
For a remaining plate, with formalin cell fixation after, add 1% aldrich mixture dyeing.With the cells survival rate of single-layer culturing cell densimeter (ォ リ Application バ ス (Olympus) corporate system) mensuration corresponding to each reagent concentration.Top result is shown in table 1-2.
Table 1-2 (result)
| Test portion ultimate density (μ g/mL) | Radix Glycyrrhizae extract adds concentration (μ g/mL) | The whitening degree | Cells survival rate (%) | |
| Cistus ladaniferus L. extract *1 | 10 | 100 | ++ | 102 |
| Acid blend *2 | 5 | 100 | ++ | 108 |
| Mixtures of methyl esters *2 | 5 | 100 | ++ | 97 |
| The ethyl ester mixture *2 | 5 | 100 | ++ | 93 |
| Chemical compound 1 *2 | 5 | 100 | ++ | 95 |
| Chemical compound 4 *2 | 5 | 100 | ++ | 96 |
| Chemical compound 7 *2 | 5 | 100 | ++ | 98 |
| Semen Coicis extract *3 | 100 | 100 | ++ | 97 |
| Cistus ladaniferus L. extract *1 | 20 | 0 | + | 100 |
| Acid blend *2 | 10 | 0 | + | 92 |
| Mixtures of methyl esters *2 | 10 | 0 | + | 90 |
| The ethyl ester mixture *2 | 10 | 0 | + | 90 |
| Chemical compound 1 *2 | 10 | 0 | + | 94 |
| Chemical compound 4 *2 | 10 | 0 | + | 93 |
| Chemical compound 7 *2 | 10 | 0 | + | 98 |
| Semen Coicis extract *3 | 200 | 0 | ± | 100 |
| Radix Glycyrrhizae extract *4 | 0 | 200 | ± | 98 |
*Make in 1 example 1
*Make in 2 examples 2
*Make in 3 examples 22
*The kind drugmaker of 4 balls system
As the result from table 1-2 learns, Cistus ladaniferus L extract and laudanum acids and methyl ester and ethyl ester, even independent also having suppresses to produce melanic function, and for a little less than the B16 melanoma cultured cell toxicity.Owing to further also use the whitening agent Radix Glycyrrhizae extract, relatively, obtained the reinforced effects of whitening during with individual processing.So Cistus ladaniferus L. extract and laudanum acids and methyl ester thereof and ethyl ester and white Bulbus Lilii extract collocation, be applied to skin, brought into play the effect that extremely good inhibition melanin produces, can expect that its skin darkening that effectively suppresses Exposure to Sunlight and cause, brown patch, freckle etc. whiten and the skin Caring effect.
The manufacture method of [example 23] black currant (Network ロ Off サ ス グ リ) fruit extract
10g black currant (Ribes nigrum L.) fruit is pulverized, added 50vol% aquiferous ethanol 100mL, after at room temperature carrying out extracting in 3 days, obtain black currant (Network ロ Off サ ス グ リ) fruit extract (the drying solid composition is 2.4%) after filtration.
The manufacture method of [example 24] Flos Inulae (dolly) fruit extract
In the raceme of 10g Flos Inulae (Inula britannica L.), add 50vol% aquiferous ethanol 100mL, at room temperature, after carrying out extracting in 3 days, after filtration, obtain Flos Inulae (dolly) fruit extract (the drying solid composition is 0.5%).
The manufacture method of [example 25] cranberry fruit extract
The fruit of 10g cranberry (Vaccinium macrocorpon Aiton or Vaccinium oxycoccus) is pulverized, added the moisture 1,3 butylene glycol 100mL of 50vol%, at room temperature, after carrying out extraction in 3 days, after filtration, obtain cranberry fruit extract (the drying solid composition is 1.5%).
The manufacture method of [example 26] Caulis Spatholobi extract
The stem of 10g handkerchief Maca Ma Tuowu (Ha マ カ ユ マ ト ウ) (Mucuna birdwoodiana Tutcher) is pulverized, add 50vol% aquiferous ethanol 100mL, at room temperature, after carrying out extracting in 3 days, after filtration, obtain Caulis Spatholobi extract (the drying solid composition is 1.5%).
The manufacture method of [example 27] Betula platyphylla Suk. resin
With method, take effusive liquid, and obtain Betula platyphylla Suk. resin (the drying solid composition is 0.8%) the perforation of the tree of the Betula platyphylla Suk. (Betula platyphylla Sukatchuvvar.Japonica Hara) before blooming.
[example 28] vows the manufacture method of the real extract of car
Vow in the fruit of car real (Alnus firma Sieb.et Zucc.) at 10g, add 50vol% aquiferous ethanol 100mL, at room temperature, after carrying out extracting in three days, after filtration, obtain to vow the real extract (the drying solid composition is 1.0%) of car.
[example 29] Radix et Caulis Opuntiae Dillenii extract's manufacture method
Make the stipes drying of general Supreme Being Si Putakanda difficult to understand (Opuntia Streptacantha), in its 10g powder, add distilled water 100mL, extraction is 8 hours under 70 ℃ of conditions.Filter after the cooling, after the filtrate concentrate drying solidifies, add the moisture 1,3 butylene glycol 100g of 30vol%, dissolving obtains Radix et Caulis Opuntiae Dillenii extract's (the drying solid composition is 1.0%).
The manufacture method of [example 30] Fructus Momordicae extract
In 10g Mo Modikageluoben in the dry fruit of (Momordica grosbenorii Swingle), add 50vol% aquiferous ethanol 100mL, at room temperature, after carrying out extracting in 3 days, after filtration, obtain Fructus Momordicae extract (the drying solid composition is 1.3%).
[example 31: emulsifiable paste]
The various emulsifiable pastes of composition shown in the table 2-2 have been modulated.
At first, blending constituent (1)～(6) after heating, remain in 70 ℃ the mixture, add the composition (16) that remains on 70 ℃ through heating again.And then, behind remix composition (7)～(15),, and obtain emulsifiable paste through cooling.
To the various emulsifiable pastes that obtain,, investigated and whitened and the skin Caring effect with following test method.
(test method)
Respectively every kind of test portion emulsifiable paste is formed panel by 27～54 years old 15 of women, estimate, every morning and evening twice after washing one's face, smear an amount of test emulsifiable paste on the face, in 12 weeks on probation,, estimated and whitened and the skin Caring effect by following standard.Evaluation result is represented with each number of estimating panel.
(evaluation criterion)
＜estimate＜content 〉
Gloomy obvious disappearance of effective skin.
Slightly effectively skin is gloomy not too obvious.
Invalid do not have to change with use is preceding.
(composition and result)
As show shown in the result of 2-2, with product relatively relatively with all compositions (composition (8)～(13)) of Cistus ladaniferus L. extract and above-mentioned (B2) composition and the present invention's product emulsifiable paste of usefulness, be used for skin, can more effectively prevent, improve the gloomy of skin, reach the effect of skin Caring.
[example 32 usefulness cell culture carry out the cell-stimulating test]
Use neonatal fibroblast NB1RGB.Get an amount of culture medium on 24 orifice plates, sowing fibroblast NB1RGB under 37 ℃ of conditions, is statically placed in the carbon dioxide that concentration is 5vol%.Second day, add the mix reagent modulating liquid, make to obtain the laudanum acids that obtains in Cistus ladaniferus L. extract, the example 2 in the example 1 and the ultimate density of methyl ester and ethyl ester is 0 (contrast), 5,10 μ g/mL; The cell activator Radix et Caulis Opuntiae Dillenii extract is 0,100 μ g/mL.Changed culture medium, and added the reagent modulating liquid once again in the 4th day that cultivates.Second day, remove culture medium, after cell is cleaned with phosphate buffer, reclaim, be contrast with the cell number of the fibroblast NB1RGB that breeds in each reagent modulating liquid, the cell proliferation rate after is estimated as a comparison.
In addition, as a comparative example,, also carried out same test for knowing the soybean extract (100 μ g/mL) that the cell-stimulating effect is arranged.Soybean extract is in the 10g soybean seed, adds 70vol% aquiferous ethanol 100mL, after at room temperature carrying out extracting in 3 days, obtains after filtration.At this moment the dry solid state component of soybean extract is 0.5%.
(evaluation criterion)
Add all ingredients and adjust liquid, the cell number of the cell number of breeding and contrast relatively, its cell proliferation rate as index, has been estimated the cell-stimulating effect.Calculated cell number with the hemocytometer abacus again.
Table 3-2 (result)
| Test portion adds concentration (μ g/mL) | The Radix et Caulis Opuntiae Dillenii extract adds concentration (μ g/mL) | Cell-stimulating rate (%) | |
| Cistus ladaniferus L. extract *1 | 10 | 100 | 230 |
| Acid blend *2 | 5 | 100 | 290 |
| Mixtures of methyl esters *2 | 5 | 100 | 280 |
| The ethyl ester mixture *2 | 5 | 100 | 305 |
| Chemical compound 1 *2 | 5 | 100 | 300 |
| Chemical compound 4 *2 | 5 | 100 | 310 |
| Chemical compound 7 *2 | 5 | 100 | 315 |
| Soybean extract *3 | 100 | 100 | 170 |
| Cistus ladaniferus L. extract *1 | 20 | 0 | 120 |
| Acid blend *2 | 10 | 0 | 130 |
| Mixtures of methyl esters *2 | 10 | 0 | 125 |
| The ethyl ester mixture *2 | 10 | 0 | 135 |
| Chemical compound 1 *2 | 10 | 0 | 128 |
| Chemical compound 4 *2 | 10 | 0 | 130 |
| Chemical compound 7 *2 | 10 | 0 | 135 |
| Soybean extract *3 | 200 | 0 | 108 |
| The Radix et Caulis Opuntiae Dillenii extract *4 | 0 | 200 | 110 |
*Make in 1 example 1
*Make in 2 examples 2
*Make in 3 examples 32
*Make in 4 examples 29
As the result of table 3-2 shows, confirm that this plant extract has the cell-stimulating ability to neonatal fibroblast NB1RGB.When with cell activator Radix et Caulis Opuntiae Dillenii extract and time spent, stronger cell-stimulating ability is arranged.Therefore, because cell activator of the present invention is Cistus ladaniferus L. extract and laudanum acids and methyl ester thereof and ethyl ester and Radix et Caulis Opuntiae Dillenii extract to be arranged in pairs or groups be used for skin, so brought into play extremely good aging resistance effect, expect its can effectively improve because of old, be exposed to wrinkle of skin that ultraviolet etc. produces, Dermatochalasia etc.
[example 33: emulsifiable paste]
The various emulsifiable pastes of composition shown in the table 4-2 have been modulated respectively.
At first, blending constituent (1)～(6) remain in after heating in 70 ℃ the mixture, add a part that remains on 70 ℃ composition (16) through heating.Composition (7)～(15) are mixed in this, and cooling then obtains emulsifiable paste.
To the various emulsifiable pastes that obtain,, investigated the effect of improving wrinkle with following test method.
*Make in 1 example 1
*Make in 2 examples 26
*Make in 3 examples 27
*Make in 4 examples 28
*Make in 5 examples 29
*6 Sigma's corporate systems
*7 Japan's refined sugar corporate systems
(test method)
To every kind of test portion emulsifiable paste, form panel by 20 of 35～59 years old women respectively, every day, morning and evening twice, an amount of emulsifiable paste is smeared on the face in the back that washes one's face, and uses for 12 weeks.Improve the effect of wrinkle after smearing by following standard evaluation.
(evaluation criterion)
＜estimate＜content 〉
Effectively the wrinkle of skin has obviously disappeared.
Slightly effectively the wrinkle of skin becomes not too obvious.
Invalid do not have to change with use is preceding.
Shown in the result of table 4, learn with product relatively and compare that the Cistus ladaniferus L. extract and (B) emulsifiable paste of the present invention of various compositions of composition and usefulness are used for skin, can improve " wrinkle " of skin etc., become resilient beautiful skin.
[example 34: emulsifiable paste]
Following composition (1)～(10), heating is mixed to 70 ℃.In this mixture, add being blended in mixed composition (11)～(13) of heating under 70 ℃ of conditions, (22) and (25), and then, add blending constituent (14)～(21), (23) and (24) again, be cooled to room temperature then, obtain emulsifiable paste.
(composition) (%)
(1) cetostearyl alcohol 3.0
(2) fatty acid glyceride 2.0
(3) single oleic acid polyethylene glycol oxide (20) sorbitan 1.0
(4) sorbitan single-stearic hydrochlorate 1.0
(5) N-stearoyl-N-methylamino ethyl sulfonic acid sodium 0.5
(6) vaseline 5.0
(7) dimethyl polysiloxane 3.0
(8) three-2 ethyl hexanoic acid glyceryls 20.0
(9) the dl-alpha-tocopherol 1.0
(10) titanium oxide 1.0
(11) dipropylene glycol 10.0
(12) the L-magnesium ascorbyl phosphate 3.0
(13) sodium citrate 0.5
(14) glycyrrhizic acid dipotassium 0.1
(15) lactic acid (50% aqueous solution) 0.1
(16) Caulis Spatholobi extract
*1 0.1
(17) glucose rutin extract
*2 0.3
(18) Radix et Caulis Opuntiae Dillenii extract
*3 0.02
(19) Fructus Momordicae extract
*4 0.02
(20) Betula platyphylla Suk. resin
*5 5.0
(21) disodium edetate 0.03
(22) antiseptic is an amount of
(23) spice is an amount of
(24) Cistus ladaniferus L. extract
*6 0.5
(25) distilled water surplus
*Make in 1 example 26
*2 Japan's refined sugar corporate systems
*Make in 3 examples 29
*Make in 4 examples 30
*Make in 5 examples 27
*Make in 6 examples 1
[example 35: water-in-oil type emulsifiable paste]
Following composition (1)～(8), heating is mixed to 70 ℃.In this mixture, add being blended in heat under 50 ℃ of conditions mixed composition (9)～(16), (18)～(21), adding ingredient (17) obtains the water-in-oil type emulsifiable paste again.
(composition) (%)
(1) the hydrogenation soybean phospholipid 0.05
(2) polyoxyalkylene modified organic silicon oxygen alkane 2.0
(3) the hydroxy stearic acid cholesterol 2.0
(4) cholesterol 0.2
(5) three decanes 2.0
(6) decamethylcyclopentasiloxane 7.0
(7) two isooctyl acid ethylene glycol 15.0
(8) the 4-tert-butyl group-4 '-methoxyl group DBM 1.0
(9) the L-magnesium ascorbyl phosphate 3.0
(10) sodium citrate 0.5
(11) disodium edetate 0.05
(12) ethanol 2.0
(13) 1,3 butylene glycol 5.0
(14) crystalline cellulose 2.0
(15) spherical nylon end 1.0
(16) antiseptic is an amount of
(17) spice is an amount of
(18) Cistus ladaniferus L. extract
*1 0.3
(19) vow the real extract of car
*2 0.1
(20) Fructus Momordicae extract
*3 0.1
(21) distilled water surplus
*Make in 1 example 1
*Make in 2 examples 28
*Make in 3 examples 30
Example 34 and the 35 various emulsifiable pastes that obtain, all be to have lasting stability, being used for skin to preventing and improving the respond well of the gloomy skin, brown patch and the freckle that are caused by Exposure to Sunlight and old wrinkle that causes and Dermatochalasia, is the various skin Caring cosmetics that transparent feel is arranged.
[example 36: the agent of washing one's face]
Following composition (1)～(10) heating is mixed, maintain 70 ℃, it is cooled to room temperature, add again and mix (11)～(14), obtain to wash one's face agent.
(composition) (%)
(1) N-coco-nut oil fatty acid acyl group-L-glutamic acid triethanolamine 20.0
(2) lauryl decil acid betanin 10.0
(3) coco-nut oil fatty acid diethyl alcohol amide 3.0
(4) coco-nut oil fatty acid potassium 5.0
(5) stearic acid 2.0
(6) glycerol 20.0
(7) PEG400 5.0
(8) erithritol 2.0
(9) propylene glycol 10.0
(10) antiseptic is an amount of
(11) spice is an amount of
(12) Cistus ladaniferus L. extract
*1 1.0
(13) Semen Coicis extract
*2 1.0
(14) distilled water surplus
*Make in 1 example 1
*Make in 2 examples 22
The agent of washing one's face that obtains, exhibiting excellent stability with time is used for skin, be transparent feel arranged make the beautiful agent of washing one's face of skin.
[example 37: gel cosmetic products]
Following composition (1)～(5) and (16) heating are mixed, be cooled to room temperature.In this mixture, add being blended in blended (6)～(10) of heating under 70 ℃ of conditions, and then, add again and mix (11)～(15) and the acquisition gel cosmetic products.
(composition) (%)
(1) methylcellulose 2.0
(2) xanthan gum 1.0
(3) sodium alginate 0.2
(4) alkyl-modified carboxylation ethene polymers 0.2
(5) hyaluronate sodium 1% aqueous solution 2.0
(6) glycerol 10.0
(7) Macrogol 2000 0 1.0
(8) methyl glucoside 2.0
(9) the hydrogenation egg yolk lecithin 0.2
(10) plant sterol 0.1
(11) sodium hydroxide 0.1
(12) antiseptic is an amount of
(13) spice is an amount of
(14) Cistus ladanifcrus L. extract
*1 0.001
(15) black currant extract
*2 0.3
(16) distilled water surplus
*Make in 1 example 1
*Make in 2 examples 23
[example 38: oleogel cosmetics]
Mixing is heated in following composition (1)～(9) under 70 ℃ of conditions, be cooled to room temperature.In this mixture, add and mix (10) and (16), and then interpolation mixes (11)～(15) and obtains the oleogel cosmetics again.
(composition) (%)
(1) polyethylene glycol oxide (20) polypropylene oxide (4) cetyl ether 1.0
(2) polyethylene glycol oxide (20) three isostearic acid glyceryls 0.2
(3) alkyl-modified carboxylation ethene polymers 0.2
(4) glycerol 10.0
(5) dipropylene glycol 2.0
(6) 1,3 butylene glycol 5.0
(7) polyoxyethylene (10) methyl glucoside 0.2
(8) three-2 ethyl hexanoic acid glyceryls 75.0
(9) three decanes 2.0
(10) triethanolamine 0.1
(11) antiseptic is an amount of
(12) spice is an amount of
(13) Cistus ladaniferus L. extract
*1 0.005
(14) astaxanthin
*2 0.05
(15) rutin glucoside
*3 0.05
(16) distilled water surplus
*Make in 1 example 1
*2 Sigma's corporate systems
*3 Japan's refined sugar corporate systems
[example 39: astringent]
The mixture behind following composition (1)～(9) and (12), (16) mixed dissolution, add and be mixed in composition (10), (11), (13)～(15) and (17)～(21), and obtain astringent.
(composition) (%)
(1) Macadamia nut oil 0.01
(2) borage grass oil 0.01
(3) sad cetyl 0.01
(4) three-2 ethyl hexanoic acid glyceryls 0.01
(5) acetic acid-dl-alpha-tocopherol 0.02
(6) sesquialter oleic acid sorbitan 0.1
(7) single oleic acid polyethylene glycol oxide (20) sorbitan 0.1
(8) polyethylene glycol oxide (8) alkyl ether phosphoric acid 0.2
(9) ethanol 10.0
(10) Sorbitol (70% aqueous solution) 5.0
(11) glycerol 1.0
(12) 2-hydroxyl-4-methoxy benzophenone-5-sodium sulfonate 0.2
(13) lactic acid (50% aqueous solution) 0.1
(14) sodium lactate (50% aqueous solution) 0.3
(15) antiseptic is an amount of
(16) spice is an amount of
(17) Cistus ladaniferus L. extract
*1 0.01
(18) glycyrrhizic acid dipotassium 0.1
(19) vow the real extract of car
*2 0.05
(20) Radix Glycyrrhizae extract
*3 0.05
(21) distilled water surplus
*Make in 1 example 1
*Make in 2 examples 28
*The kind drugmaker of 3 balls system
[example 40: astringent]
The mixture behind composition (1)～(9) mixed dissolution, adding is mixed in (10)～(16) and obtains astringent.
(composition) (%)
(1) the gamma-linoleic acid sucrose ester 0.05
(2) single isostearic acid polyethylene glycol oxide (50) sclerosis castor bean oil 1.0
(3) different Palmic acid L-ascorbic acid 0.1
(4) polyethylene glycol oxide (10) alkyl ether phosphoric acid 0.1
(5) methoxyl group cinnamic acid octyl group 0.05
(6) glycerol 3.0
(7) the L-serine 0.1
(8) 1,3 butylene glycol 5.0
(9) ethanol 8.0
(10) sodium citrate 0.02
(11) citric acid 0.05
(12) antiseptic is an amount of
(13) spice is an amount of
(14) Cistus ladaniferus L. extract
*1 0.05
(15) Flos Inulae extract
*2 0.2
(16) distilled water surplus
*Make in 1 example 1
*Make in 2 examples 24
[example 41: nebulousurine astringent]
The mixture behind following composition (1)～(10) mixed dissolution, add in composition (11)～(19) be mixed in behind the mixed dissolution, and obtain the nebulousurine astringent.
(composition) (%)
(1) polyethylene glycol oxide (60) sclerosis castor bean oil 0.7
(2) the polyethylene oxide alkyl ethers sodium phosphate 0.2
(3) cholesterol 0.01
(4) the hydrogenation egg yolk lecithin 0.02
(5) dimethyl polysiloxane 0.05
(6) acetic acid-dl-alpha-tocopherol 0.5
(7) p-methoxycinnamate 2-ethylhexyl 0.2
(8) the enoxolone stearoyl 0.1
(9) ethanol 15.5
(10) polyethylene glycol 6000 0.2
(11) citric acid 0.01
(12) phosphoric acid one disodium hydrogen 0.2
(13) astaxanthin
*1 0.0001
(14) antiseptic is an amount of
(15) spice is an amount of
(16) Cistus ladaniferus L. extract
*2 0.002
(17) rutin glucoside
*3 0.001
(18) black currant fruit extract
*4 0.1
(19) distilled water surplus
*1 Sigma's corporate system
*Make in 2 examples 1
*3 Japan's refined sugar corporate systems
*Make in 4 examples 23
[example 42: emulsion]
Following composition (1)～(8) heating is mixed to 70 ℃.In this mixture, add and mix, under 70 ℃ of conditions, heat blended (9)～(11) and (17), cooling.Add again therein and mix (12) and (13)～(16), obtain emulsion.
(composition) (%)
(1) the hydrogenation soybean phospholipid 3.0
(2) cholesterol 0.2
(3) polyethylene glycol oxide (5) cetyl ether 0.2
(4) polyethylene glycol oxide (10) sclerosis castor bean oil 1.0
(5) cetostearyl alcohol 2.0
(6) Fructus Canarii albi three decanes 5.0
(7) dipropylene glycol 7.0
(8) 1,3 butylene glycol 5.0
(9) trimethyl glycine 2.0
(10) hydroxypropyl emthylcellulose 0.1
(11) carboxyl ethylene polymer 0.2
(12) potassium hydroxide 0.1
(13) antiseptic is an amount of
(14) spice is an amount of
(15) Cistus ladaniferus L. extract
*1 0.1
(16) Radix et Caulis Opuntiae Dillenii extract
*2 0.5
(17) distilled water surplus
*Make in 1 example 1
*Make in 2 examples 29
[example 43: ultra light sun block lotion]
Heating mixes in 70 ℃ of following compositions of condition (1)～(11), makes it be separated into pulpous state.Dissolving mixed composition (12)～(14) and (16)～(20) under 50 ℃ of conditions are blended in this, adding ingredient (15) again, and obtain ultra light sun block lotion.
(composition) (%)
(1) two capric acid neopentyl ethylene glycol 10.0
(2) p-methoxycinnamate-2-ethylhexyl 5.0
(3) octamethylcy-clotetrasiloxane 10.0
(4) decamethylcyclopentasiloxane 10.0
(5) dimethyl polysiloxane 5.0
(6) particulate titanium dioxide 10.0
(7) particulate oxide zinc 5.0
(8) polyalkylene modified organic silicon oxygen alkane 5.0
(9) the enoxolone stearoyl 0.3
(10) nylon powder 2.0
(11) the polyethylene end 1.0
(12) glycerol 5.0
(13) ethanol 5.0
(14) antiseptic is an amount of
(15) spice is an amount of
(16) Cistus ladaniferus L. extract
*1 0.2
(17) glycyrrhizic acid dipotassium 0.1
(18) Caulis Spatholobi extract
*2 0.1
(19) cranberry extract
*3 0.1
(20) distilled water surplus
*Make in 1 example 1
*Make in 2 examples 26
*Make in 3 examples 25
[example 44: water-in-oil type sunscreen frost]
Under 70 ℃ of conditions, following composition (1)～(8) heating is mixed.Mixed composition (9)～(13) and (15)～(18) interpolation of heating under 50 ℃ of conditions is mixed in this, and adding ingredient (14) obtains the water-in-oil type sunscreen frost again.
(composition) (%)
(1) polyalkylene modified organic silicon oxygen alkane 2.0
(2) the Palmic acid octyl group 15.0
(3) decamethylcyclopentasiloxane 20.0
(4) San behenic acid glyceryls 1.0
(5) particulate oxide zinc 12.0
(6) particulate titanium dioxide 3.0
(7) p-methoxycinnamate-2-ethylhexyl 7.0
(8) the 4-tert-butyl group-4 '-methoxyl group DBM 1.0
(9) astaxanthin
*1 0.05
(10) dipropylene glycol 5.0
(11) ethanol 5.0
(12) the polyethylene end 3.0
(13) antiseptic is an amount of
(14) spice is an amount of
(15) Cistus ladaniferus L. extract
*2 0.2
(16) Betula platyphylla Suk. resin
*3 0.2
(17) vow the real extract of car
*4 0.2
(18). distilled water surplus
*1 Sigma's corporate system
*Make in 2 examples 1
*Make in 3 examples 27
*Make in 4 examples 28
[example 45: beautifying liquid]
Modulated under 50 ℃ of conditions,, be cooled to the mixture of room temperature composition (7)～(12) and (19) mixing of heating.In this mixture, add solution and composition (13)～(18) of following composition (1)～(6) behind mixed dissolution under 50 ℃ of conditions, obtain sticking beautifying liquid.
(composition) (%)
(1) isostearic acid polyethylene glycol oxide (50) sclerosis castor bean oil 0.2
(2) the hydrogenation soybean phospholipid 0.5
(3) glycerol 7.0
(4) the dl-alpha-tocopherol 0.3
(5) cholesterol 0.1
(6) ethanol 6.0
(7) 2-hydroxyl-4-methoxy benzophenone-5-sodium sulfonate 0.2
(8) the L-magnesium ascorbyl phosphate 0.5
(9) citric acid 0.01
(10) sodium citrate 0.1
(11) xanthan gum 0.1
(12) methylcellulose 0.1
(13) Cistus ladaniferus L. extract
*1 0.1
(14) Radix Glycyrrhizae extract
*2 0.1
(15) Semen Coicis extract
*3 0.1
(16) cranberry fruit extract
*4 0.1
(17) antiseptic is an amount of
(18) spice is an amount of
(19) distilled water surplus
*Make in 1 example 1
*The kind drugmaker of 2 balls system
*Make in 3 examples 22
*Make in 4 examples 25
[example 46: beauty and make-up cream]
Under 70 ℃ of conditions, following composition (1)～(5) and (19) heating is mixed, be cooled in the mixture after the room temperature, add blending constituent (6)～(18) and obtain beauty and make-up cream.
(composition) (%)
(1) polyvinyl alcohol 15.0
(2) glycerol 10.0
(3) polyethylene glycol oxide (10) methyl glucoside 3.0
(4) three sad glyceryls 5.0
(5) the polyethylene oxide alkyl ethers sodium phosphate 1.0
(6) ethanol 20.0
(7) potter's clay 2.0
(8) titanium oxide 2.0
(9) Sargassum extract 0.1
(10) glycyrrhizic acid dipotassium 0.1
(11) Radix et Caulis Opuntiae Dillenii extract
*1 0.1
(12) Betula platyphylla Suk. resin
*2 1.0
(13) Flos Inulae extract
*3 0.1
(14) lactic acid (50% aqueous solution) 0.5
(15) sodium lactate (50% aqueous solution) 0.5
(16) antiseptic is an amount of
(17) spice is an amount of
(18) Cistus ladaniferus L. extract
*4 0.02
(19) distilled water surplus
*Make in 1 example 29
*Make in 2 examples 27
*Make in 3 examples 24
*Make in 4 examples 1
[example 47: liquid foundation cream]
Following composition (1)～(7) heating is mixed, in this mixture, heat blending constituent (13)～(18), be maintained at 70 ℃.In remaining in 70 ℃ the mixture of composition (8)～(12), add the mixture of front, evenly carry out emulsifying.After the cooling, adding ingredient (19)～(22) obtain liquid foundation cream.
(composition) (%)
(1) the dipentaerythritol fatty acid ester 2.0
(2) Liquid Paraffin 5.0
(3) stearic acid 2.0
(4) spermol 1.0
(5) the self-emulsifying type monostearin 1.0
(6) p-methoxycinnamate-2-ethylhexyl 8.0
(7) antiseptic is an amount of
(8) glycerol 5.0
(9) triethanolamine 1.0
(10) carboxymethyl cellulose 0.2
(11) bentonite 0.5
(12) distilled water surplus
(13) titanium oxide 6.0
(14) particulate titanium dioxide 2.0
(15) particulate oxide zinc 4.0
(16) Muscovitum 2.0
(17) Talcum 4.0
(18) coloring pigment is an amount of
(19) Cistus ladaniferus L. extract
*1 0.01
(20) Semen Coicis extract
*2 0.5
(21) vow the real extract of car
*3 1.0
(22) spice is an amount of
*Make in 1 example 1
*Make in 2 examples 22
*Make in 3 examples 28
The various cosmetics that obtained by example 37～47 all are to have lasting stability, are used for skin and prevent and improve the respond well of the gloomy skin, brown patch and the freckle that cause by Exposure to Sunlight and old wrinkle that causes and Dermatochalasia, and be the skin Caring cosmetics that transparent feel is arranged.
Industrial utilizability
As described above, the present invention can provide the skin makeup effect, especially whitening and/or prevent the aging good skin preparations for extenal use of effect. This good result is by above-mentioned general formula (1) represented compound and specific composition and usefulness, and the enhancing effect that reaches, the represented compound of above-mentioned general formula (1) when using separately and special component when using separately, inaccessiable significantly good skin makeup, whitening and/or prevent aging effect.
Claims (3)
1. skin whitening external agent contains in (A) one or more following general formula (1), general formula (1) R
1Expression-CH
2OH or COOR
6, R
6Expression hydrogen, carbon number be 1～3 low alkyl group or can with the salifiable cation of COO shape, R
2～R
5Independent respectively expression hydrogen atom or methyl ... A ... expression=C (CH
3)-,-C (CH
3)=,-C (=CH
2)-,-CH (CH
3)-or-C (OH) (CH
3The chemical compound of)-expression, (B) be selected from the active ingredient that the moisture 1,3 butylene glycol extract of 50vol% of 50vol% aquiferous ethanol extract, Flos Inulae 50vol% aquiferous ethanol extract, the cranberry fruit of one or more the 70vol% aquiferous ethanol extract by oil-soluble Radix Glycyrrhizae extract, Semen Coicis, black currant fruit constitutes
General formula (1)
2. one kind prevents skin aging external agent, contains in (A) one or more following general formula (1), general formula (1) R
1Expression-CH
2OH or COOR
6, R
6Expression hydrogen, carbon number be 1～3 low alkyl group or can with the salifiable cation of COO shape, R
2～R
5Independent respectively expression hydrogen atom or methyl ... A ... expression=C (CH3)-,-C (CH3)=,-C (=CH
2)-,-CH (CH
3)-or-C (OH) (CH
3The chemical compound of)-expression and (B1) active ingredient that constitutes of one or both the Purified Water extract that is selected from Radix et Caulis Opuntiae Dillenii, astaxanthin
General formula (1)
3. claim 1 or 2 described external agent, the represented chemical compound of described general formula (1) be the following compounds 1,4 extracted in one or more the plant among the plant group who constitutes by the Cistus ladaniferus L. that is selected from Cistaceae, Cistus creticus L., CistusMonopehensis L., Cistus salvifolius and 7 and this chemical compound through the chemical compound of esterification, or the following compounds 3,6 and 9 of ethyl esterization
Chemical compound 1 chemical compound 4
Chemical compound 2 chemical compounds 5
Chemical compound 3 chemical compounds 6
Chemical compound 7
Chemical compound 8
Chemical compound 9
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP323502/2002 | 2002-11-07 | ||
| JP2002323502A JP4091824B2 (en) | 2002-02-05 | 2002-11-07 | Skin preparation |
| JP323503/2002 | 2002-11-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1713889A CN1713889A (en) | 2005-12-28 |
| CN100463666C true CN100463666C (en) | 2009-02-25 |
Family
ID=35719192
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB038255774A Expired - Lifetime CN100463666C (en) | 2002-11-07 | 2003-07-30 | Composition for preparation for external use on skin and method of using the same |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100463666C (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100382798C (en) * | 2006-01-20 | 2008-04-23 | 深圳市生物谷科技有限公司 | Pharmaceutical composition containing caffeoylquinic acids |
| CN101185622B (en) * | 2007-07-16 | 2011-05-04 | 孙敏 | Oil-controlling, anti-blackening and skin-whitening cream |
| CN101874822A (en) | 2009-04-27 | 2010-11-03 | 玫琳凯有限公司 | Botanical anti-acne formulations |
| KR20110001407A (en) | 2009-06-30 | 2011-01-06 | (주)아모레퍼시픽 | Composition containing rehmannia glutinosa, radix glycyrrhizae, semen coicis, fructus hordei, fructus chaenomelis, cortex acanthopanacis, or radix puerariae extract for promoting adipocyte differenciation |
| KR20120047932A (en) * | 2009-07-08 | 2012-05-14 | 아크레이 가부시키가이샤 | Carboxymethylarginine production inhibitor and collagen denaturation inhibitor |
| KR101736503B1 (en) * | 2010-08-06 | 2017-05-16 | 가부시키가이샤 시세이도 | Elastase inhibitor |
| US20120156266A1 (en) * | 2010-12-17 | 2012-06-21 | Chong Jin Loy | Compositions comprising lilium candidum extracts and uses thereof |
| EP3566691B1 (en) | 2011-12-19 | 2024-04-17 | Mary Kay Inc. | Cosmetic method of whitening skin and evening tone with azuki beans |
| KR102323049B1 (en) | 2014-03-10 | 2021-11-05 | 마리 케이 인코포레이티드 | Skin lightening compositions |
| JP6305157B2 (en) * | 2014-03-28 | 2018-04-04 | 株式会社コーセー | Composition, cosmetics |
| CN106048766B (en) * | 2016-05-27 | 2018-06-15 | 东莞市澳莉莎家用纺织品有限公司 | A kind of erosion prevention and muscle growing fabric containing fibroin and preparation method thereof |
| CN105943444A (en) * | 2016-06-07 | 2016-09-21 | 胡小丽 | Method for preparing pregnant woman nursing cream |
| CN106420474A (en) * | 2016-11-02 | 2017-02-22 | 芜湖光荣网络科技有限公司 | Cosmetic composition containing active ingredients of plant extract |
| CN109044962A (en) * | 2018-07-31 | 2018-12-21 | 亳州市新健康科技有限公司 | A kind of vaginal plugging gel and its preparation process |
| CN109846869B (en) * | 2019-01-28 | 2021-09-14 | 广东省微生物研究所（广东省微生物分析检测中心） | Application of 2-hydroxy-4-methoxy-5-sulfonic acid benzophenone in preparation of medicine for treating/preventing hyperuricemia related diseases |
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