CN100457713C - Method for prudicing amino-diphenylamine - Google Patents
Method for prudicing amino-diphenylamine Download PDFInfo
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- CN100457713C CN100457713C CNB2004100028658A CN200410002865A CN100457713C CN 100457713 C CN100457713 C CN 100457713C CN B2004100028658 A CNB2004100028658 A CN B2004100028658A CN 200410002865 A CN200410002865 A CN 200410002865A CN 100457713 C CN100457713 C CN 100457713C
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- copper
- alkali
- aniline
- title complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/30—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds
- C07C209/32—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups
- C07C209/36—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of nitrogen-to-oxygen or nitrogen-to-nitrogen bonds by reduction of nitro groups by reduction of nitro groups bound to carbon atoms of six-membered aromatic rings in presence of hydrogen-containing gases and a catalyst
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
- C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
- C07C209/10—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to carbon atoms of six-membered aromatic rings or from amines having nitrogen atoms bound to carbon atoms of six-membered aromatic rings
Abstract
The present invention relates to a process for the production of aminodiphenyl-amines, such as 4-aminodiphenylamine (4-ADPA), by reacting nitrohalogenated benzenes with anilines in the presence of a base as well as a copper-phosphorus complex, followed by hydrogenation of the intermediately formed nitrodiphenyl-amines.
Description
Invention field
The present invention relates to produce aminodiphenylamine, the method for 4-aminodiphenylamine (4-ADPA) for example, this method is in the presence of alkali and copper-phosphorus title complex halogenated nitrobenzene and aniline to be reacted, and subsequently the intermediate product nitrodiphenylamine that forms is carried out hydrogenation reaction.
Background of invention
4-aminodiphenylamine (4-ADPA) is a kind of important as precursors thing of synthetic anti-aging agent, is the stablizer in rubber and the polymer industry.(Kirk-Othmer，Encyclopedia of Chemical Technology，4thEdition，1992，Vol.3，pp.424-456；Ullmann′s Encyclopedia of Industrial Chemistry，5th Edition，Vol.A3，1985，pp.91-111)。
The production method of 4-ADPA is a lot.A kind of possible method is to produce 4-ADPA with two elementary reactions that aniline or anils and right-nitro-chlorobenzene carry out, and this is reflected at a kind of acid acceptor or a kind of neutralizing agent and exists down and carry out, and a kind of catalyzer existence is optionally arranged.For example at DE-A 3 246 151, DE-A3 501698, DE-A 185 663, U.S. Patent number 4,670 in 595,4,187,249,4,683,332 and 4,187,248, is described the preparation method according to this method.Copper catalyst is used in the reaction of fs usually, and subordinate phase uses the metal ingredient different with it to make catalyzer, as nickel (seeing for example U.S. Patent number 5,840,982).For example, as the halogenated nitrobenzene and being reflected among US-A 5 576 460 and the EP-A 846676 of amine of catalyzer description is arranged with palladium.
The above-mentioned shortcoming of making the production method of catalyzer with copper is that with regard to generating required diarylamine, the selectivity of reaction is relatively poor relatively.Generally the productive rate of triarylamine is 5-15%, the distillatory expense increased when this caused the finished product purifying, and because the consumption increase of expensive halogenated nitrobenzene is also uneconomical, because every formation monovalent triarylamine will consume two equivalent halogenated nitrobenzenes.In addition, the processing of byproduct has also brought ecological problem.
Therefore, expectation provides a kind of production method of aminodiphenylamine, and this method is set out by aniline, by reacting with corresponding halogenated nitrobenzene, obtain nitrodiphenylamine with higher productive rate, the generation of triarylamine simultaneously reduces, with the intermediate product reduction, finally obtain the aminodiphenylamine of wanting subsequently.
(Tetrahedron Letters such as Venkataraman, 2001,42,4791-4793) demonstration uses the title complex of preformed dibrominated copper and triphenyl phosphine to produce a kind of new catalyzer, and this catalyzer can add to aryl halide catalysis aromatic secondary amine and form triarylamine.
Yet shown among the erect image comparative example, to compare with Cu/Cs (copper/caesium) catalysis system of mentioning among DE3 246 151 A1, the reaction that aryl halide is added to primary amine does not provide any significant advantage.
Therefore, surprisingly in the reaction of halogenated nitrobenzene and aniline, use certain copper-phosphorus title complex only to produce and seldom measure unwanted byproduct triarylamine.It also is unexpected that these title complexs strengthen the catalytic activity that generates the nitrodiphenylamine reaction.
Summary of the invention
Therefore, the invention provides a kind of production method of aminodiphenylamine, this method is included under a kind of alkali and the existence of a kind of catalyzer halogenated nitrobenzene and aniline is reacted, and with traditional method the intermediate product nitrodiphenylamine that forms is carried out hydrogenation reaction then, wherein uses general formula
Copper-phosphorus the title complex of representative is as catalyzer, in molecular formula (1):
X can be identical also can be different, represent O, NH, S or C
nH
2n, its condition is for each X, n can from representative 0,1,2 or 3 in select arbitrarily.
M can be identical also can be different, represent C
6-C
18-aryl, C
1-C
19-alkyl, C
7-C
19-aralkyl or representative have the heteroaryl of 1-3 heteroatoms and 6-19 carbon atom, and wherein two or more M groups can be at random be connected by covalent linkage bridge or the alkylidene bridge that contains 1-4 carbon atom.
Y represents halogen or trifluoroacetyl group, trifyl, nine fluorine fourth alkylsulfonyls, prussiate, ethanoyl, can choose that fluorizated is acetylacetone based wantonly, nitrate radical, aryl sulfonyl, oxine base, phosphate radical, carbonate or tetrafluoroborate.
Z represents 1,2 or 3,
M represents the integer from 1-6,
R represent 0,1 or 2 and
S represents 0 or 1.
X preferably represents methylene radical or ethylidene group in general formula (I)
M represents phenyl, xenyl or naphthyl; Or representative contains heteroaryl, particularly pyridyl or the quinolyl of 1-3 nitrogen-atoms and 5-12 carbon atom; Or represent C
1-C
12-alkyl, this alkyl also can be side chains, for example: methyl, ethyl, n-propyl, sec.-propyl, normal-butyl, the tertiary butyl, cyclopentyl or cyclohexyl.Y represents chlorine, bromine or iodine or represents trifyl or acetonyl.
In above-mentioned general formula (I), preferred z represents numeral 1 or 2, and m represents numeral 1,2, or 3, r represents numeral 1 or 2, and s represents 0.
Above-mentioned general formula (I) comprises copper-phosphine composition and copper-phosphinate title complex, also can be copper-phosphorous acid ester title complex
Detailed Description Of The Invention
Suitable copper-phosphine composition is with following compounds those title complexs as the basis of its phosphine ligand: three-neighbour-tolylphosphine, tricyclohexyl phosphine, three-cyclopentyl phosphine, three-tert-butyl phosphine, three-just-butyl phosphine, two diphenylphosphino ethane, two diphenylphosphino propane, two diphenylphosphino butane, two dicyclohexyl phosphino-ethane, two diphenylphosphino ferrocene, 5,5 '-two chloro-6-6 '-dimethoxy biphenyl-2,2 '-two-Ji-two-diphenylphosphine, two-4,4 '-diphenylene-oxide-3,3 '-Ji-two diphenylphosphines, 1,1 '-two-diphenylphosphine yl diphenyl ether, two (2-dicyclohexyl phosphino-)-2 '-(N, N dimethylamine) biphenyl, 2-(dicyclohexyl phosphino-)-biphenyl, 2-(dicyclohexyl phosphino-)-2 '-methyl diphenyl, 2-(2-tertiary butyl phosphino-) biphenyl or 2-(two diphenylphosphino)-dinaphthalene, preferred 2-(2-tertiary butyl phosphino-) biphenyl or 2-(dicyclohexyl phosphino-) biphenyl, copper wherein has 0 valency, + I valency or+the II valency, the coordinate copper compound is based on following compounds: copper oxide, copper halide, the copper prussiate, neutralized verdigris, with the acetylacetonate copper of fluoridizing or the nonfluorinated form exists, cupric nitrate, copper trifluoromethanesulfcomposite, aryl sulfonic acid copper, copper 8-quinolinolate, cupric phosphate, be preferably based on cupric chloride (I), cupric bromide (I), cupric iodide (I), cupric bromide (II), cupric chloride (II), neutralized verdigris (II), cupric oxide (II) or acetylacetonate copper (II), and copper powder, particularly based on cupric chloride (I), cupric bromide (I) or copper trifluoromethanesulfcomposite (I).
Preferred copper-phosphine composition is those by 2-(2-tertiary butyl phosphino-) biphenyl and 2-(dicyclohexyl phosphino-) biphenyl as ligand, and cupric bromide (I) or copper trifluoromethanesulfcomposite are as the title complex of copper or copper compound.
In the methods of the invention, the example that is used as copper-phosphinate title complex comprises and contains following compound those title complexs as the phosphonous acid ylidene ligands, for example: 1,1 '-biphenyl-2-base-dialkylphosphinic acids ester, preferred 1,1 '-biphenyl-2-base-dicyclohexyl phosphinate, 1,1 '-biphenyl-2-base-2-tertiary butyl phosphinate, 3-[(di-isopropyl-phosphino-) oxygen] phenyl di-isopropyl phosphinate, 3-[(two-tertiary butyl phosphino-) oxygen] phenyl two-tertiary butyl phosphinate, the 3-[(diphenylphosphino) oxygen] phenyl phenylbenzene phosphinate or 3-[(dicyclohexyl phosphino-) oxygen] phenyl dicyclohexyl phosphinate, more preferably 3-[(di-isopropyl-phosphino-) oxygen] phenyl di-isopropyl phosphinate, and also they are based on the title complex of aforesaid copper compound or copper itself.
Copper-phosphinate phosphine composition the example that is fit to is based on following phosphorous acid ester and the above-mentioned copper compound or the title complex of copper itself.
Therefore, can enumerate the title complex that has following part as copper-phosphorous acid ester title complex: triphenyl phosphorous acid ester, three-(2, the 4-di-tert-butyl-phenyl) phosphorous acid ester, 1,1 '-dinaphthalene-2,2 '-two bases-sec.-propyl phosphorous acid ester or 2,4,8,10-tetra-tert-6-phenoxy group-12H-dibenzo [d, g]-[1,3,2] two oxa-phosphorus heterocycle octenes.
Preferably contain the copper-phosphorous acid ester title complex of triphenyl phosphorous acid ester or three-(2, the 4-di-tert-butyl-phenyl) phosphorous acid ester as the phosphorous acid ylidene ligands.
The above-mentioned copper of mentioning-phosphorus title complex can use separately also can mix use each other arbitrarily.Can be by the composition of suitable preliminary experiment decision ideal mixture.
In the present invention, the copper-phosphorus title complex of used general formula (I) representative is by molecular formula (II)
The phosphorus compound and the molecular formula (III) of representative
Cu-Y
r(III)
The copper compound reaction of representative makes, M wherein, and X, Y is identical among the s, the implication of z and r and general formula (I).
In order to prepare the copper-phosphorus title complex of general formula (I) representative, the initial substance of general formula (II) and general formula (III) representative is with a certain mixed in molar ratio, so that form the target title complex of general formula (I) representative of wanting.Usually the mol ratio of the copper compound of the phosphorus compound of general formula (II) and general formula (III) is about 40: 1 to 0.5: 1, and preferred 5: 1 to 1: 1, more preferably 4: 1 to 1: 1.
This copper-phosphorus title complex can prepare in being suitable for the inert organic solvents of this purpose, for example: tetrahydrofuran (THF), ether, toluene, dimethylbenzene, chloroform, methylene dichloride, methyl alcohol and/or ethanol.
Can determine the optimum consumption of solvent by suitable preliminary experiment.
From above-mentioned molecular formula (II) and (III) initial compounds of representative prepare copper-phosphorus title complex, be by at ambient temperature simple mixing of the solution of two kinds of initial compounds being finished.
In halogenated nitrobenzene and aniline reaction process, also can prepare copper-phosphorus title complex on the spot.
This means and copper-phosphorus title complex can be added in halogenated nitrobenzene and the aniline reaction, perhaps just as already mentioned, during entire reaction, finally form copper-phosphorus title complex on the spot.
The consumption of copper-phosphorus title complex is generally 0.02-10% (molar percentage), is preferably 0.1-3% (molar percentage), is basic calculation with the consumption of halogenated nitrobenzene.
The halogenated nitrobenzene of Shi Yonging in the method for the invention, nitryl group wherein are preferably in the contraposition of halogen atom.Suitable halogen atom is fluorine, chlorine or bromine, preferred fluorine and chlorine.Also can substitute halogenated nitrobenzene, for example, contain triflate substituting group or nine fluorine fourth sulphonate substituting groups or the substituent oil of mirbane of carbamate with other activated oil of mirbane.Obviously, halogenated nitrobenzene and other active oil of mirbane can coverlet replace or polysubstituted, for example can be replaced by alkyl, preferably contain the alkyl of 1-12 carbon atom, particularly contain 1-4 carbon atom.Obviously, nitryl group also can be in contraposition, for example at the ortho position or in a position with respect to the position of halogen atom or active group.
Following substances can be used as halogenated nitrobenzene, for example: and 4-nitro-2-methyl chlorobenzene, 4-nitro-3-methyl fluorobenzene, 4-nitro-chlorobenzene, 3-nitro-chlorobenzene or 2-nitro-chlorobenzene, preferably use the 4-nitro-chlorobenzene.
Routine material can be used as active oil of mirbane down, for example: 4-nitrophenyl triflate, 4-nitrophenyl nine fluorine fourth sulphonates or 4-nitrophenyl carbamate; Preferred 4-nitrophenyl triflate.
The aniline that can be used in the inventive method comprises: except that aniline self, also can be the aniline of ortho position, a position or para-orientation.Following radicals is suitable for as substituting group: the C of branching or non-branching
1-C
29-alkyl or C
1-C
39-alkenyl contains acyl group, alkylthio, alkylamino or the alkoxyl group of 1-29 carbon atom, carboxylicesters (wherein carboxylic moiety contain 1-29 carbon atom and ester moiety contains 1-29 carbon atom), and sulfonic group (wherein ester moiety contains 1-9 carbon atom).Preferred substituents is as follows: contain the branching of aforesaid carbonatoms or not branched-alkyl, alkenyl or alkylthio, for example, octyl group, decyl, dodecyl, oil base, myristyl or stearyl.
Following substances can be used as the aniline of replacement: vinyl aniline, 4-tertiary butyl aniline, right-anisidine, o-methoxyaniline, neighbour-Tolylamine, right-Tolylamine, methyl o-aminobenzoate, neighbour-aminobenzonitrile, right-aminobenzonitrile, 4-ethylaniline.The preferred aniline that uses.
According to method of the present invention, the active oil of mirbane of every moles of halogenated oil of mirbane or every mole need with corresponding aniline amount be the 1-10 mole, preferred 1.5-8 mole, more preferably 2-6 mole.
Can be used for carbonate, alcoholate, phosphoric acid salt, fluorochemical and/or oxyhydroxide that alkali in the inventive method comprises basic metal and/or alkaline-earth metal, wherein can enumerate salt of wormwood, yellow soda ash, cesium carbonate, cesium bicarbonate, sodium methylate, potassium tert.-butoxide, amylalcohol potassium, cesium fluoride, potassiumphosphate and hydrated barta.Preferred salt of wormwood, yellow soda ash, cesium carbonate and/or the cesium bicarbonate of using.
More preferably use salt of wormwood.
The usage quantity of alkali can be lower than stoichiometry, also can excessive 10 times of equivalents until halogenated nitrobenzene.Special preferred bases consumption is for being equivalent to the normal halogenated nitrobenzene of 0.3-2.
If used alkali then helps the inventive method through grinding and/or dry pre-treatment.
Milled processed in the inventive method can be finished with for example commercially available mill.By attrition process, the specific surface of alkali is enlarged greatly, causes transformation efficiency obviously to increase.In a lot of situations, attrition process makes specific surface enlarge 10-20 doubly.
The alkali specific surface area is about 0.1-10m after the attrition process
2/ g, preferred 0.2-1m
2/ g (BET).
In the methods of the invention, because used alkali has significant water absorbability, its phosphoric acid salt and carbonate are to atmosphere composition existence obvious absorption more or less, for example: water and carbonic acid gas.If the initial absorption rate to the atmosphere composition is 30% (weight percent), the transformation efficiency that then can record reaching produces remarkably influenced.For this reason, except carrying out attrition process, also to carry out drying treatment to alkali.
According to the character of used alkali, can heat a few hours to alkali under preferred 100 ℃-160 ℃ temperature and under the low pressure of about 0.01-100 millibar (mbar), with the alkali drying treatment at 50 ℃-200 ℃.
According to the inventive method, the reaction of fs can be carried out in 20 ℃-250 ℃ temperature range, and preferred range is 110 ℃-210 ℃.Temperature of reaction depends on the character of used initial substance, catalyzer and alkali.
According to the present invention, no matter whether there is suitable solvent, this method can be implemented.The solvent that is fit to comprises, for example the organic hydrocarbon of inertia such as dimethylbenzene and toluene.Used in addition aromatic amine also can be used as solvent.
In the methods of the invention, if desired, can be by distillation, for example by entrainer, the water that may form in the removal production process is similar to DE-A 2 633 811 and DE-A 3 246 151 is described.
Can determine the amount of solvent for use at an easy rate by suitable preliminary experiment.
The inventive method can according to traditional method in a continuous manner or intermittent mode implement.
When generating aminodiphenylamine, can finish the reduction and the hydrogenation reaction of resulting nitrodiphenylamine by reductive agent (as: hydrogen), can be randomly carry out having under the copper situation, and can randomly add suitable inertia catalytic carrier.
Also can in the presence of other hydrogenation catalysts, carry out hydrogenation reaction, for example, can randomly use suitable catalytic carrier based on the catalyzer of nickel, palladium and platinum.
The material that is suitable as catalytic carrier comprises the support of the catalyst on all conventional arts, as the carrier based on the various application forms of carbon, oxide compound, carbide or salt.The example of carbon-containing carrier is coke, graphite, carbon black or activated carbon.The example of oxide catalyst carrier is SiO
2(natural or synthetic silicic acid, quartz), Al
2O
3(alpha, gamma-Al
2O
3), clay, natural or synthetic aluminium silicate (zeolite), layered silicate such as wilkinite and polynite, TiO
2(rutile, anatase octahedrite), ZrO
2, MgO or ZnO.The example of carbide and salt is SiC, AlPO
4, BaSO
4, CaCO
3By and large, synthetic materials can be as using derived from for example carrier of natural materialss such as float stone, kaolin, discoloring clay, alumina, wilkinite, diatomite, asbestos or zeolite.
Preferred activated carbon and contain the material of silicon, aluminium, magnesium, zirconium, titanium as carrier.
More preferably activated carbon.
Also can utilize and well known to a person skilled in the art that other method of reducing finish hydrogenation reaction, the method described in for example exist " Reductions in Organic Chemistry, Second Edition, ACS Monograph 188 ".
Hydrogenation conditions is: 0 ℃-200 ℃ of temperature, preferred 40 ℃-150 ℃; Pressure (pressure of hydrogen) 0.1-150 crust, preferred 05-70 crust, more preferably 1-50 crust.
Can obtain corresponding aminodiphenylamine according to the inventive method, this method has high selectivity (＞95%), and its output reaches 97% of theoretical value.
The present invention also provides the nitrodiphenylamine product, and this product obtains as reaction intermediate, and this reaction is according to the method for the invention, and halogenated nitrobenzene and aniline react in the presence of the copper-phosphorus title complex of alkali and general formula (I) representative.
To further illustrate the present invention, but the present invention is not limited to following embodiment, wherein all umbers and percentage ratio are by weight, unless otherwise specified.
Embodiment
The preparation of copper-phosphine composition
Embodiment 1
The preparation of two (2-(di-t-butyl phosphino-) biphenyl) cupric bromide (I)
Anhydrous methanol in the reflux temperature heating 50ml degassing joins 2.36g (7.9 mmole) 2-(di-t-butyl phosphino-) biphenyl in the methyl alcohol, dissolves fully up to phosphine compound lentamente.Then 0.59g (2.6 mmole) cupric bromide (II) is joined in the solution in batches.Further heated 15 minutes at reflux temperature after adding cupric bromide, then cooling solution.After the solution cooling, filter the precipitation that forms, with small amount of ethanol and diethyl ether washing, dry then.Can obtain 0.93g (1.1 mmole) aforesaid compound.Productive rate is 80% of a theoretical value.
Embodiment 2
The 3-[(diphenylphosphino) oxygen] preparation of phenyl phenylbenzene phosphinate cupric chloride (I)
In round-bottomed flask, with 5g (10.4 mmole) 3-[(diphenylphosphino) oxygen] phenyl phenylbenzene phosphinate is dissolved in the anhydrous methylene chloride of the degassing, is heated to 40 ℃.Add 0.35g (0.35 mmole) cupric chloride (I).Stir after 30 minutes, go down to desolventize at vacuum condition.Can obtain above-claimed cpd.
Embodiment 3
Two polymeric 1,1 '-preparation of biphenyl-2-base-dicyclohexyl phosphinate cupric chloride (I)
In round-bottomed flask, 5g (13.6 mmole) 1,1 '-biphenyl-2-base-dicyclohexyl phosphinate is dissolved in the anhydrous chloroform of the degassing.In argon gas stream, add 0.45g (4.5 mmole) cupric chloride (I), stirred 6 hours in room temperature.Go down to desolventize at vacuum condition, absorb residual solvent with anhydrous diethyl ether.Solution is cooled to-78 ℃, so product is precipitated out.
Embodiment 4
Two polymeric 4-isopropoxy dinaphthos [2.1-d:1 ', 2 '-f] preparation of [1,3,2] two oxa-phosphorus heterocycle heptene cupric chlorides (I)
In round-bottomed flask, with 5g (13.4 mmole) 4-isopropoxy dinaphtho [2.1-d:1 ', 2 '-f] [1,3,2] two oxa-phosphorus heterocycle heptene (rac.-dinaphthalene sec.-propyl phosphorous acid ester) are dissolved in the methylene dichloride, add 0.44g (0.45 mmole) cupric chloride (I) in argon gas stream.Stir after 30 minutes, go down to desolventize in vacuum.
Embodiment 5
Making precursor with cupric bromide (I) produces copper-phosphine composition catalyst on the spot and carries out the 4-NDPA condensation
In the four-hole boiling flask of the 1000ml capacity that mechanical stirrer, Vigreux column, water separator (being full of with 35ml dimethylbenzene) are housed, under nitrogen environment stirs, add 288.9g (3090 mmole) aniline, (8.16g 27 mmole) 2-(di-t-butyl phosphino-)-biphenyl, (3.87g 27 mmole) cupric bromide (I), 83.6g (605 mmole) potassium carbonate powder and 157.6g (1000 mmole) right-nitro-chlorobenzene (p-NCB) are heated to reflux temperature with whole system.In reaction process, the water of formation on a small quantity to increasing gradually, upward keeps constant at a low levels (the about 9ml of total volume) by initial then.The temperature of reaction mixture rises to 200 ℃ from 189 ℃ of beginning.Every sampling in 30 minutes (not filtering), detect the value of determining transformation efficiency and 4-NDPA/ triarylamine by HPLC.4.5 finish experiment after hour.Detecting the residual volume of finding p-NCB is 0.66% (weight percent) (the corresponding transformation efficiency of p-NCB is 99%), 4-NDPA content is 41.2% (weight percent), 4,4 '-dinitrobenzene triphenylamine content be 0.78% and the ratio of 4-NDPA/ triarylamine be 52: 1 (selectivity corresponding to 97% and p-NCB of the theoretical value of 4-NDPA is 98%).
Embodiment 6
Use preformed Cu
2Br
2(2-di-t-butyl phosphino-biphenyl)
2Make catalyzer (decrease) and carry out the 4-NDPA condensation
In the four-hole boiling flask of the 1000ml capacity that mechanical stirrer, Vigreux column, water separator (being full of with 35ml dimethylbenzene) are housed, in room temperature, nitrogen gas stream is under 50 liters of/hour conditions, adds 3.22g (3.64 mmole) Cu in 372g (3.99 moles) aniline
2Br
2(2-di-t-butyl phosphino-biphenyl)
2, stirred 10 minutes.Add 157.6g (1.00 moles) right-nitro-chlorobenzene (abbreviation p-NCB) and 96.6g (700 mmole) potassium carbonate powder then, be heated to and be lower than reflux temperature.The separation of water is a constant when refluxing beginning.The temperature of reaction mixture rises to 196 ℃ from 189 ℃ of beginning.Sampling from reaction mixture (filtering) with the value that HPLC determines its composition and 4-NDPA/ triarylamine, is cooled off reaction system after 5 hours.Residual volume that detect to find p-NCB is 0.66% (weight percent) (corresponding transformation efficiency is 84%), the value of 4-NDPA/ triarylamine be 59 (corresponding 4-NDPA productive rate be 82.4% and the selectivity of p-NCB be 98%).
Embodiment 7
Make copper-phosphine composition (decrease) that precursor generates on the spot with cupric bromide (I) and carry out the 4-NDPA condensation as catalyzer
In the four-hole boiling flask of the 1000ml capacity that mechanical stirrer, Vigreux column, water separator (being full of with 35ml dimethylbenzene) are housed, in nitrogen atmosphere with under stirring, add 288.9g (3090 mmole) aniline, 242g (8.1 mmole) 2-(two-tert-butyl phosphino-)-biphenyl, (1.16g 8.1 mmole) cupric bromide (I), 83.6g (605 mmole) potassium carbonate powder and 157.6g (1000 mmole) p-NCB is heated to reflux temperature with content.In reaction process, the water of formation on a small quantity to increasing gradually, upward keeps constant at a low levels (the about 7ml of total amount) by initial then.The temperature of reaction mixture rises to 198 ℃ from 189 ℃ of beginning.Every sampling in 30 minutes (not filtering), determine the value of transformation efficiency and 4-NDPA/ triarylamine by HPLC.Finish experiment after 7 hours.Detecting the residual volume of finding p-NCB is 4.2% (weight percent) (corresponding transformation efficiency is 89%), 4-NDPA content is 37.2% (weight percent), 4,4 '-dinitrobenzene triphenylamine content is 1.9%, the value of 4-NDPA/ triarylamine be 33 (corresponding 4-NDPA productive rate be 86% and the selectivity of p-NCB be 97%).
Embodiment 8
Make copper-phosphine composition that precursor prepares on the spot with trifluoromethanesulfonic acid Cu (I) benzene title complex and carry out the 4-NDPA condensation as catalyzer
In the four-hole boiling flask of the 1000ml capacity that mechanical stirrer, Vigreux column, water separator (being full of with 35ml dimethylbenzene) are housed, adding 288.9g (3090 mmole) aniline, 2.14g (27 mmole) cupric oxide (II), 83.6g (605 mmole) potassium carbonate powder and 157.6g (1000 mmole) p-NCB, is to be heated to reflux temperature under about 150 liters of/hour conditions in nitrogen gas stream then.Isolate about 0.4ml water after short period of time.0.5 after hour, reaction mixture is cooled to about 120 ℃, adds 4.53g (8.1 mmole) copper trifluoromethanesulfcomposite (I) benzene title complex and 2.42g (8.1 mmole) 2-(two-tert-butyl phosphino-)-biphenyl ligand.Under nitrogen gas stream condition slowly, again reaction mixture is heated to reflux temperature then.After this, begin to be irregularly formed less water, however the generation of water reduce gradually, stop (about 0.5ml) after 2 hours at the latest fully.The temperature of reaction mixture rises to 196 ℃ from 188 ℃ of beginning.Take a sample after 6 hours, determine the composition of reaction mixture by HPLC.Finish experiment then.Detecting the residual volume of finding p-NCB is 4.0% (weight percent) (corresponding transformation efficiency is 89%), 4-NDPA content is 39.6% (weight percent), 4,4 '-dinitrobenzene triphenylamine content is 1.2%, the value of 4-NDPA/ triarylamine be 33 (corresponding 4-NDPA productive rate be 86.4% and the selectivity of p-NCB be 86%).
Embodiment 9
On 10 mmole scales, carry out the 4-NDPA condensation as catalyzer with copper-phosphine/phosphorous acid ester and phosphinate
In the 10ml reaction vessel, add 1.58g (10 mmole) p-NCB, 0.95g (6.9 mmole) salt of wormwood, 21.5mg (0.25 mmole) cupric oxide Cu (II) O, 15.5mg (0.08 mmole) CsHCO
3, 3.75g (40 mmole) aniline, the reaction system of composition standard.P-NCB in catalyst screening, salt of wormwood and aniline remain unchanged, but the various catalyst consumption that will test are 0.25 mmole.The cooling tube of filling molecular sieve is connected on the reaction vessel.In the agitating heater of 200 ℃ and 530rpm, react.Afterreaction was finished in 4 hours.To be cooled after about 40 ℃, in each reaction system, take a sample, analyze by HPLC.
| Examined catalyzer | Transformation efficiency (p-NCB) [%] | Productive rate 4-NDPA [%] | Selectivity 4-NDPA/ triarylamine |
| Cu(II)O/CsHCO 3(reference) | 70 | 67 | 22∶1 |
| 1,1 '-Lian is stupid-2-base-two-tertiary butyl phosphine/acetylacetone copper (II) | 87 | 85 | 57∶1 |
| 1,1 '-biphenyl-2-base-two-tertiary butyl phosphine/venus crystals (II) | 86 | 85 | 63∶1 |
| 1,1 '-biphenyl-2-base-dicyclohexyl phosphinate/cupric chloride (I) dipolymer | 75 | 73 | 39∶1 |
| Cu(II)O/2PP H3(comparative example *) | 50 | 48 | 25∶1 |
*) be similar to Venkataraman etc. [Tetrahedron Letters, 2001,
42, 4791-4793]
Comparative example 1 (being similar to DE 3 246 151 A1)
Carry out the 4-NDPA condensation with Cu (II) O-/Cs as catalyzer
In the four-hole boiling flask of the 1000ml capacity that mechanical stirrer, Vigreux column, water separator (being full of with 35ml dimethylbenzene) are housed, add 288.9g (3090 mmole) aniline, (2.44g 12.6 mmole) cesium bicarbonate, (2.14g 27 mmole) cupric oxide (II), 83.6g (605 mmole) potassium carbonate powder and 157.6g (1000 mmole) para-nitrochloro-benzene (p-NCB) heats reaction mixture under reflux temperature.Simultaneously stream of nitrogen gas is regulated and ease up, so that keep inert gas environment.From about 189 ℃ of separation that begin to occur water, and in reaction process, continue to keep.Up to 5.5 hours post-reacted terminal points, temperature of reaction rose to about 203 ℃ always.Determine the composition of reaction mixture by HPLC.Detecting the residual volume of finding p-NCB is 0.1% (weight percent) (p-NCB transformation efficiency＞99%), 4-NDPA content is 44.8% (weight percent), 4,4 '-dinitrobenzene triphenylamine content is 2.1%, the ratio of 4-NDPA/ triarylamine is 2l (selectivity that corresponding 4-NDPA productive rate is 87.5% and p-NCB of theoretical value is 88%).
Comparative example 2 (being similar to DE 3 246 151 A1)
Cu (II) O-/Cs with decrease carries out the 4-NDPA condensation as catalyzer
In the four-hole boiling flask of the 1000ml capacity that mechanical stirrer, Vigreux column, water separator (being full of with 35ml dimethylbenzene) are housed, add 288.9g (3090 mmole) aniline, 733mg (3.78 mmole) cesium bicarbonate, 642mg (8.1 mmole) cupric oxide (II), 83.6g (605 mmole) potassium carbonate powder and 157.6g (1000 mmole) 4-nitro-chlorobenzene heats reaction mixture refluxed.Simultaneously stream of nitrogen gas is regulated and ease up, so that keep inert gas environment.From about 189 ℃ of separation that begin to occur water, and in reaction process, continue to keep.Up to 5 hours post-reacted terminal points, temperature of reaction rose to about 201 ℃ always.Determine the composition of reaction mixture by HPLC.Detecting the residual volume of finding p-NCB is 12.5% (weight percent) (corresponding p-NCB transformation efficiency is 63%), 4-NDPA content is 22.6% (weight percent), 4,4 '-dinitrobenzene triphenylamine content is 1.1%, the ratio of 4-NDPA/ triarylamine be 21 (corresponding 4-NDPA productive rate be 60% and the selectivity of p-NCB be 95%).
Embodiment 10 (preparation of 4-ADPA)
After the reaction mixture among the embodiment 8 is cooled to 105 ℃, add 250ml water, stirred whole systems 15 minutes in 80 ℃, transfer to then in the separating funnel.After being separated fully, in isolating organic phase (500ml), add 5ml KOH, 25ml salts solution (coming the liquid phase of self-condensation) and 4.5g Raney nickel (Raney nickel), transfer in the autoclave that carries out hydrogenation reaction, reaching 140 ℃, hydrogen dividing potential drop in temperature is under the 10 crust conditions, and hydrogenation reaction continues 400 minutes.Gas chromatographic analysis shows that the productive rate of 4-aminodiphenylamine is 99% (with reference to used 4 nitrodiphenyl amine).
Though with illustration invention is described in detail in front, but what know is, such detailed description only is to illustrate for example, except the content that claim limited, those skilled in the art can make various changes under the situation that does not depart from spirit of the present invention and invention scope.
Claims (9)
1. the production method of aminodiphenylamine, this method comprises halogenated nitrobenzene and the reactions steps of aniline in the presence of alkali and catalyzer, wherein catalyzer is the copper-phosphorus title complex of general formula (1) representative,
In general formula (1),
X is identical or different and represents O, NH, S or C
nH
2n, its condition is for each X, n is optional and represents 0,1,2 or 3,
M is identical or different and represents 2-(di-t-butyl phosphino-) biphenyl ligand and 2-(dicyclohexyl phosphino-) biphenyl ligand,
Y represents halogen or trifluoroacetyl group, trifyl, nine fluorine fourth alkylsulfonyls, prussiate, ethanoyl, and optional fluorizated is acetylacetone based, nitrate radical, aryl sulfonyl, oxine base, phosphate radical, carbonate or tetrafluoroborate,
Z represents 1,2 or 3,
M represents the integer from 1-6,
R represents 0,1 or 2,
S represents 0 or 1,
Wherein, middle product nitrodiphenylamine is carried out hydrogenation.
2. the copper that the process of claim 1 wherein-phosphorus title complex is by molecular formula (II)
The phosphorus compound and the molecular formula (III) of representative
Cu-Y
r (III)
The copper compound prepared in reaction of representative obtains, and wherein M, X, Y, s, z and r are identical with implication in the general formula (I).
3. the method for claim 2, molecular formula wherein (I) is copper-phosphine composition, copper-phosphinate title complex or copper-phosphorous acid ester title complex.
4. the halogenated nitrobenzene that the process of claim 1 wherein is selected from 4-nitro-2-methyl chlorobenzene, 4-nitro-3-methyl fluorobenzene, 4-nitro-chlorobenzene, 3-nitro-chlorobenzene or 2-nitro-chlorobenzene, 4-nitro-chlorobenzene, 4-nitrophenyl triflate, 4-nitrophenyl nine fluorine fourth sulphonates or 4-nitrophenyl carbamate and 4-nitrophenyl trifluoromethane sulfonic acid ester.
5. the aniline that the process of claim 1 wherein is the aniline of a kind of ortho position, a position or para-orientation.
6. the method for claim 5, wherein the aniline of Qu Daiing is selected from vinyl aniline, 4-tertiary butyl aniline, right-anisidine, o-methoxyaniline, neighbour-Tolylamine, right-Tolylamine, Methyl anthranilate, neighbour-aminobenzonitrile, right-aminobenzonitrile and 4-ethylaniline.
7. the alkali that the process of claim 1 wherein is selected from the carbonate of alkali-metal carbonate, alkali-metal alcoholate, alkali-metal phosphoric acid salt, alkali-metal fluorochemical, alkali-metal oxyhydroxide, alkaline-earth metal, the alcoholate of alkaline-earth metal, the phosphoric acid salt of alkaline-earth metal, the fluorochemical of alkaline-earth metal, the oxyhydroxide of alkaline-earth metal and their mixture.
8. the method for claim 7, alkali wherein is selected from salt of wormwood, yellow soda ash, cesium carbonate, cesium bicarbonate, sodium methylate, potassium tert.-butoxide, amylalcohol potassium, cesium fluoride, potassiumphosphate and hydrated barta.
9. the production method of nitrodiphenylamine, this method is at a kind of alkali and a kind of general formula (I)
The copper of representative-phosphorus title complex exists down, halogenated nitrobenzene and aniline reacted,
Wherein,
X is identical or different, represents O, NH, S or C
nH
2n, its condition is for each X, n is optional, represents 0,1,2 or 3,
M is identical or different, represents 2-(di-t-butyl phosphino-) biphenyl ligand and 2-(dicyclohexyl phosphino-) biphenyl ligand,
Y represents halogen or trifluoroacetyl group, trifyl, nine fluorine fourth alkylsulfonyls, prussiate, ethanoyl, and optional fluorizated is acetylacetone based, nitrate radical, aryl sulfonyl, oxine base, phosphate radical, carbonate or tetrafluoroborate,
Z represents 1,2 or 3,
M represents the integer from 1-6,
R represent 0,1 or 2 and
S represents 0 or 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10300126A DE10300126A1 (en) | 2003-01-07 | 2003-01-07 | Process for the preparation of aminodiphenylamines |
| DE10300126.3 | 2003-01-07 |
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| Publication Number | Publication Date |
|---|---|
| CN1517332A CN1517332A (en) | 2004-08-04 |
| CN100457713C true CN100457713C (en) | 2009-02-04 |
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| CNB2004100028658A Expired - Fee Related CN100457713C (en) | 2003-01-07 | 2004-01-07 | Method for prudicing amino-diphenylamine |
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| Country | Link |
|---|---|
| US (1) | US6946577B2 (en) |
| EP (1) | EP1437340B1 (en) |
| JP (1) | JP2004210787A (en) |
| KR (1) | KR20040063808A (en) |
| CN (1) | CN100457713C (en) |
| AT (1) | ATE473959T1 (en) |
| CA (1) | CA2454455A1 (en) |
| DE (2) | DE10300126A1 (en) |
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| JP5261870B2 (en) * | 2004-10-20 | 2013-08-14 | 三菱化学株式会社 | Method for producing amine compound |
| JP5186721B2 (en) * | 2004-12-28 | 2013-04-24 | 三菱化学株式会社 | Method for producing amine compound |
| WO2006081384A2 (en) * | 2005-01-26 | 2006-08-03 | The Regents Of The University Of California | Heterogeneous copper catalysts |
| JP4876707B2 (en) * | 2006-05-10 | 2012-02-15 | 住友化学株式会社 | Method for producing 4-nitrosodiphenylamine and 4-nitrodiphenylamine |
| JP2012046463A (en) * | 2010-08-30 | 2012-03-08 | Sumitomo Chemical Co Ltd | Method for producing aromatic amine compound |
| CN106946720A (en) * | 2017-03-23 | 2017-07-14 | 康爱特维迅（蓬莱）化学有限公司 | A kind of preparation method of diphenylamines |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3246151A1 (en) * | 1982-12-14 | 1984-06-14 | Bayer Ag, 5090 Leverkusen | Process for the preparation of 4-nitrodiphenylamines |
| US6313373B1 (en) * | 1998-10-30 | 2001-11-06 | Case Western Reserve University | Tissue specific promoters and transgenic mouse for the screening of pharmaceuticals |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE185663C (en) | ||||
| DE2633811C2 (en) | 1976-07-28 | 1983-11-10 | Bayer Ag, 5090 Leverkusen | Process for the preparation of nitrodiphenylamines |
| US4187248A (en) | 1977-11-23 | 1980-02-05 | Monsanto Company | Making a nitrodiarylamine by reacting an alkali metal salt of a formamide with a nitrohaloarene |
| US4187249A (en) | 1977-12-27 | 1980-02-05 | Monsanto Company | Promoting the reaction of sodium salts of formyl derivatives of aromatic amines to form nitrodiarylamines |
| DE3247151A1 (en) | 1982-12-21 | 1984-06-28 | Alex 4600 Dortmund Brose | Roll with filling, especially baguette roll and method and device for production thereof |
| DE3501698A1 (en) | 1985-01-19 | 1986-07-24 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING 4-NITRODIPHENYLAMINE |
| DE3504479A1 (en) | 1985-02-09 | 1986-08-14 | Bayer Ag, 5090 Leverkusen | METHOD FOR PRODUCING 4-NITRODIPHENYLAMINE |
| US4683332A (en) | 1985-05-20 | 1987-07-28 | The Goodyear Tire & Rubber Company | Para-nitrodiphenylamine synthesis |
| US5576460A (en) | 1994-07-27 | 1996-11-19 | Massachusetts Institute Of Technology | Preparation of arylamines |
| DE19650213A1 (en) | 1996-12-04 | 1998-06-10 | Hoechst Ag | Synthesis of aromatic amines from chloroaromatics |
| US5840982A (en) | 1998-06-04 | 1998-11-24 | Uniroyal Chemical Company, Inc. | Process for preparing para-phenylenediamine derivatives |
| DE10005601A1 (en) * | 2000-02-09 | 2001-08-16 | Bayer Ag | Process for the preparation of aminodiphenylamines |
| EP1390340B1 (en) * | 2001-04-24 | 2017-03-01 | Massachusetts Institute Of Technology | Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds |
| DE10300097A1 (en) * | 2003-01-07 | 2004-07-22 | Bayer Ag | Copper complexes and their use |
-
2003
- 2003-01-07 DE DE10300126A patent/DE10300126A1/en not_active Withdrawn
- 2003-12-24 DE DE50312884T patent/DE50312884D1/en not_active Expired - Lifetime
- 2003-12-24 EP EP03029845A patent/EP1437340B1/en not_active Expired - Lifetime
- 2003-12-24 AT AT03029845T patent/ATE473959T1/en not_active IP Right Cessation
- 2003-12-30 CA CA002454455A patent/CA2454455A1/en not_active Abandoned
-
2004
- 2004-01-02 US US10/751,314 patent/US6946577B2/en not_active Expired - Fee Related
- 2004-01-06 KR KR1020040000492A patent/KR20040063808A/en not_active Application Discontinuation
- 2004-01-06 JP JP2004001261A patent/JP2004210787A/en not_active Withdrawn
- 2004-01-07 CN CNB2004100028658A patent/CN100457713C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3246151A1 (en) * | 1982-12-14 | 1984-06-14 | Bayer Ag, 5090 Leverkusen | Process for the preparation of 4-nitrodiphenylamines |
| US6313373B1 (en) * | 1998-10-30 | 2001-11-06 | Case Western Reserve University | Tissue specific promoters and transgenic mouse for the screening of pharmaceuticals |
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| "Formation of aryl ?itrogen bonds using a soluble copper(I)catalyst". Rattan Gujadhur等人.Tetrahedron Letters,Vol.vol.42 No.no.29. 2001 |
| "Formation of aryl ?itrogen bonds using a soluble copper(I)catalyst". Rattan Gujadhur等人.Tetrahedron Letters,Vol.vol.42 No.no.29. 2001 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1437340B1 (en) | 2010-07-14 |
| ATE473959T1 (en) | 2010-07-15 |
| CN1517332A (en) | 2004-08-04 |
| CA2454455A1 (en) | 2004-07-07 |
| DE50312884D1 (en) | 2010-08-26 |
| EP1437340A1 (en) | 2004-07-14 |
| US6946577B2 (en) | 2005-09-20 |
| JP2004210787A (en) | 2004-07-29 |
| KR20040063808A (en) | 2004-07-14 |
| DE10300126A1 (en) | 2004-07-15 |
| US20040143139A1 (en) | 2004-07-22 |
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