CN100420487C - Novel soft capsule peel composition - Google Patents
Novel soft capsule peel composition Download PDFInfo
- Publication number
- CN100420487C CN100420487C CNB2007102005029A CN200710200502A CN100420487C CN 100420487 C CN100420487 C CN 100420487C CN B2007102005029 A CNB2007102005029 A CN B2007102005029A CN 200710200502 A CN200710200502 A CN 200710200502A CN 100420487 C CN100420487 C CN 100420487C
- Authority
- CN
- China
- Prior art keywords
- soft capsule
- gelatin
- water
- peel composition
- mannitol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 13
- 239000007901 soft capsule Substances 0.000 title claims abstract description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 20
- 108010010803 Gelatin Proteins 0.000 claims abstract description 14
- 239000008273 gelatin Substances 0.000 claims abstract description 14
- 229920000159 gelatin Polymers 0.000 claims abstract description 14
- 235000019322 gelatine Nutrition 0.000 claims abstract description 14
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 8
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 8
- 229930195725 Mannitol Natural products 0.000 claims abstract description 8
- 239000000594 mannitol Substances 0.000 claims abstract description 8
- 235000010355 mannitol Nutrition 0.000 claims abstract description 8
- 239000000600 sorbitol Substances 0.000 claims abstract description 8
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 7
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 7
- 230000008014 freezing Effects 0.000 claims description 2
- 238000007710 freezing Methods 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims 1
- 238000003860 storage Methods 0.000 abstract description 2
- 230000029087 digestion Effects 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 239000002775 capsule Substances 0.000 description 7
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000006837 decompression Effects 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The new soft capsule covering composition can improve the performance of soft capsule, avoid disintegration during storage and speed digestion. It consists of gelatin 38-42 wt%, glycerin 8-12 wt%, water 36-40 wt%, sorbitol 5-7 wt%, mannitol 1-2 wt% and polyglycol-400 2-4 wt% as main components.
Description
[technical field]
It is the capsule peel composition of the new soft capsule thing of content that this discovery relates to a kind of being fit to the water-soluble base.
[background technology]
Soft capsule in the market disintegrate or the slow phenomenon of stripping occur in the storage life, is the problem that runs in soft capsule development and the production, has caused the concern of Chinese scholars.
[summary of the invention]
In order to improve above ubiquitous problem, a large amount of experiments of groping has been done by my company to this.Especially to a large amount of, the comprehensively work that with water-soluble substances (PEG400) is that the soft capsule of substrate has been done especially.Consult the lot of documents report, on traditional capsule shell prescription basis,,, carry out comprehensive screening experiment as excipient, plasticizer, antioxidant etc. to wherein adding different adjuvants.The comprehensive function of these adjuvant has guaranteed capsule skin molding and stable on the one hand, also influences the crosslinked of gelatin on the other hand.Wherein, the quality of gelatin self is very important, directly influences the mouldability and the stability of capsule shell.Freezing power is an important indicator of difference gelatin grade, measurement gelatin quality, and the Gel Strength of Gelatin that this discovery is used requires at 150～250g.The glycerol that contains in the compositions, propylene glycol and sorbitol are the plasticizers of using always, help the molding of capsule skin; PEG400 and sorbitol quicken the adjuvant of stripping.The use of mannitol has drama in the compositions.Because it was not in the news in the literature, I have used this adjuvant at company's research worker in investigative test, mannitol and above-mentioned component are under a certain specific conditions of mixture ratios as a result, combined effect has produced good especially effect, the dissolubility and the stability of capsule peel composition have promptly been improved, so determined soft capsule capsule peel composition each component and composition at this moment.The main feature of this discovery is a kind of trial, grope, breakthrough experiment, belongs to minimum probability event.
[specific embodiment]
An example preferably below will be described among the present invention, but not plan scope of the present invention any restriction in addition.
Example 1:
Gelatin 100g
Glycerol 25g
Water 95g
Sorbitol 15g
Mannitol 3g
PEG400 8g
Preparation method:
Step 1: the water of mannitol, sorbitol and 15g is mixed, and heated and stirred makes it to dissolve standby.
Step 2: with the water of glycerol, PEG400 and 20g, heated and stirred makes it to dissolve standby.
Step 3: gelatin and remaining water are mixed, heated and stirred, after gelatin dissolved fully, two kinds of mixture addings with step 1 and step 2 mixed.
Step 4: be incubated 80 ℃, stop to stir decompression exhaust.Put in the heat-preserving container standby.
Example 2:
Gelatin 102g
Glycerol 24g
Water 98g
Sorbitol 14g
Mannitol 3.5g
PEG400 7.5g
Preparation method:
Step 1: the water of mannitol, sorbitol and 14g is mixed, and heated and stirred makes it to dissolve standby.
Step 2: with the water of glycerol, PEG400 and 18g, heated and stirred makes it to dissolve standby.
Step 3: gelatin and remaining water are mixed, heated and stirred, after gelatin dissolved fully, two kinds of mixture addings with step 1 and step 2 mixed.
Step 4: be incubated 80 ℃, stop to stir decompression exhaust.Put in the heat-preserving container standby.
Claims (1)
1. soft capsule peel composition is characterized in that its component is:
A) gelatin;
B) glycerol;
C) water;
D) sorbitol;
E) mannitol; With
F) PEG400;
The power of freezing of wherein said gelatin is 150～250g, and a)-f) described six kinds of percentages of ingredients content are respectively: 38～42%, 8～12%, 36～40%, 5～7%, 1～2% and 2～4%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007102005029A CN100420487C (en) | 2007-04-24 | 2007-04-24 | Novel soft capsule peel composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007102005029A CN100420487C (en) | 2007-04-24 | 2007-04-24 | Novel soft capsule peel composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101032624A CN101032624A (en) | 2007-09-12 |
| CN100420487C true CN100420487C (en) | 2008-09-24 |
Family
ID=38729490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2007102005029A Active CN100420487C (en) | 2007-04-24 | 2007-04-24 | Novel soft capsule peel composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100420487C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101474323B (en) * | 2007-12-31 | 2012-05-23 | 天津中新药业集团股份有限公司达仁堂制药厂 | Ageratum soft capsule and preparation method thereof |
| CN103349632A (en) * | 2013-06-25 | 2013-10-16 | 吴江市利达上光制品有限公司 | Preparation process of fragrance beads |
| CN104706619A (en) * | 2015-04-05 | 2015-06-17 | 吴建平 | Formula of durable capsule |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB643853A (en) * | 1946-04-13 | 1950-09-27 | Lilly Co Eli | Medicinal capsules and process of manufacture |
| JP2514093B2 (en) * | 1989-07-21 | 1996-07-10 | エスエス製薬株式会社 | Soft capsule |
| CN1429555A (en) * | 2002-12-27 | 2003-07-16 | 陈新民 | Adfuwei ester soft capsule and its preparation method |
| CN1476830A (en) * | 2003-07-17 | 2004-02-25 | 新疆特丰药业股份有限公司 | Tea-polyphenol soft capsule and its preparation process |
| JP2004167084A (en) * | 2002-11-21 | 2004-06-17 | Ina Food Ind Co Ltd | Soft capsule coating film, its raw material, and soft capsule |
| CN1522141A (en) * | 2001-07-05 | 2004-08-18 | ������ҩ��ʽ���� | Soft capsules |
| CN1791388A (en) * | 2003-04-14 | 2006-06-21 | Fmc有限公司 | Homogeneous, thermoreversible alginate films and soft capsules made therefrom |
-
2007
- 2007-04-24 CN CNB2007102005029A patent/CN100420487C/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB643853A (en) * | 1946-04-13 | 1950-09-27 | Lilly Co Eli | Medicinal capsules and process of manufacture |
| JP2514093B2 (en) * | 1989-07-21 | 1996-07-10 | エスエス製薬株式会社 | Soft capsule |
| CN1522141A (en) * | 2001-07-05 | 2004-08-18 | ������ҩ��ʽ���� | Soft capsules |
| JP2004167084A (en) * | 2002-11-21 | 2004-06-17 | Ina Food Ind Co Ltd | Soft capsule coating film, its raw material, and soft capsule |
| CN1429555A (en) * | 2002-12-27 | 2003-07-16 | 陈新民 | Adfuwei ester soft capsule and its preparation method |
| CN1791388A (en) * | 2003-04-14 | 2006-06-21 | Fmc有限公司 | Homogeneous, thermoreversible alginate films and soft capsules made therefrom |
| CN1476830A (en) * | 2003-07-17 | 2004-02-25 | 新疆特丰药业股份有限公司 | Tea-polyphenol soft capsule and its preparation process |
Non-Patent Citations (4)
| Title |
|---|
| 甘露醇的应用和生产. 刘极健.化学工程师，第2期. 2000 |
| 甘露醇的应用和生产. 刘极健.化学工程师，第2期. 2000 * |
| 药剂学. 毕殿洲主编，303，人民卫生出版社. 2001 |
| 药剂学. 毕殿洲主编，303，人民卫生出版社. 2001 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101032624A (en) | 2007-09-12 |
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| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: LIAONING SHENGSHENG MEDICINE GROUP CO.,LTD. Free format text: FORMER OWNER: LIAONING DASHENG PHARMACEUTICAL CO., LTD. Effective date: 20091016 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20091016 Address after: Hunnan wavesource street in Shenyang city of Liaoning Province, No. 16 Patentee after: LIAONING SHENGSHENG PHARMACEUTICAL GROUP Co.,Ltd. Address before: No. six, No. 8 Road, moral economic development zone, Liaoning, Shenyang Patentee before: Liaoning Dasheng Pharmaceutical Co.,Ltd. |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20150911 Address after: 110300, 6-5, Central Avenue, Xinmin County, Liaoning, Shenyang Patentee after: Liaoning Sheng Sheng Pharmaceutical Co.,Ltd. Address before: Hunnan wavesource street in Shenyang City, Liaoning province 110168 No. 16 Patentee before: LIAONING SHENGSHENG PHARMACEUTICAL GROUP Co.,Ltd. |
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| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 110300, 6-5, Central Avenue, Xinmin County, Liaoning, Shenyang Patentee after: Liaoning Ebang Pharmaceutical Co.,Ltd. Address before: 110300, 6-5, Central Avenue, Xinmin County, Liaoning, Shenyang Patentee before: Liaoning Sheng Sheng Pharmaceutical Co.,Ltd. |
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| CP01 | Change in the name or title of a patent holder |
Address after: No.6-5, Central Avenue, Xinmin City, Shenyang City, Liaoning Province Patentee after: Liaoning Haiyi Pharmaceutical Co.,Ltd. Address before: No.6-5, Central Avenue, Xinmin City, Shenyang City, Liaoning Province Patentee before: Liaoning Ebang Pharmaceutical Co.,Ltd. |
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