CN100417722C - 血液制品中病毒的灭活方法 - Google Patents
血液制品中病毒的灭活方法 Download PDFInfo
- Publication number
- CN100417722C CN100417722C CNB2006101507540A CN200610150754A CN100417722C CN 100417722 C CN100417722 C CN 100417722C CN B2006101507540 A CNB2006101507540 A CN B2006101507540A CN 200610150754 A CN200610150754 A CN 200610150754A CN 100417722 C CN100417722 C CN 100417722C
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- CN
- China
- Prior art keywords
- virus
- blood products
- value
- blood
- inactivation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 241000700605 Viruses Species 0.000 title claims abstract description 25
- 238000000034 method Methods 0.000 title claims abstract description 22
- 239000010836 blood and blood product Substances 0.000 title claims abstract description 17
- 229940125691 blood product Drugs 0.000 title claims abstract description 17
- 230000000415 inactivating effect Effects 0.000 title description 5
- 239000008280 blood Substances 0.000 claims abstract description 3
- 210000004369 blood Anatomy 0.000 claims abstract description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 11
- 239000002504 physiological saline solution Substances 0.000 claims description 6
- 238000002679 ablation Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000009413 insulation Methods 0.000 claims description 4
- 230000002779 inactivation Effects 0.000 abstract description 10
- 239000012530 fluid Substances 0.000 abstract description 3
- 239000002253 acid Substances 0.000 abstract description 2
- 230000007935 neutral effect Effects 0.000 abstract description 2
- 239000003513 alkali Substances 0.000 abstract 1
- 230000009849 deactivation Effects 0.000 description 5
- 241000710960 Sindbis virus Species 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 238000009928 pasteurization Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006101507540A CN100417722C (zh) | 2006-10-25 | 2006-10-25 | 血液制品中病毒的灭活方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006101507540A CN100417722C (zh) | 2006-10-25 | 2006-10-25 | 血液制品中病毒的灭活方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1944638A CN1944638A (zh) | 2007-04-11 |
CN100417722C true CN100417722C (zh) | 2008-09-10 |
Family
ID=38044293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2006101507540A Active CN100417722C (zh) | 2006-10-25 | 2006-10-25 | 血液制品中病毒的灭活方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100417722C (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1249952A (zh) * | 1998-10-07 | 2000-04-12 | 上海市血液中心 | 血浆病毒灭活的方法及其装置 |
CN1376520A (zh) * | 2002-02-28 | 2002-10-30 | 华兰生物工程股份有限公司 | 一种冻干人血浆病毒灭活方法 |
WO2006091038A1 (en) * | 2005-02-25 | 2006-08-31 | Medigenes Co., Ltd. | Pharmaceutical composition for treating avellino cornea dystrophy comprising blood plasma or serum |
-
2006
- 2006-10-25 CN CNB2006101507540A patent/CN100417722C/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1249952A (zh) * | 1998-10-07 | 2000-04-12 | 上海市血液中心 | 血浆病毒灭活的方法及其装置 |
CN1376520A (zh) * | 2002-02-28 | 2002-10-30 | 华兰生物工程股份有限公司 | 一种冻干人血浆病毒灭活方法 |
WO2006091038A1 (en) * | 2005-02-25 | 2006-08-31 | Medigenes Co., Ltd. | Pharmaceutical composition for treating avellino cornea dystrophy comprising blood plasma or serum |
Also Published As
Publication number | Publication date |
---|---|
CN1944638A (zh) | 2007-04-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Tonrol Bio-Pharmaceutical Co., Ltd. Assignor: China Radiation Protection Research Inst. Contract fulfillment period: 2009.4.15 to 2015.4.14 contract change Contract record no.: 2009340000030 Denomination of invention: Inactivating method for virus in blood products Granted publication date: 20080910 License type: Exclusive license Record date: 2009.4.15 |
|
LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.4.15 TO 2015.4.14; CHANGE OF CONTRACT Name of requester: TONGLU BIOLOGY PHARMACY CO., LTD. Effective date: 20090415 |