CN100398119C - Medicine for improving sleep quality and its preparation method - Google Patents
Medicine for improving sleep quality and its preparation method Download PDFInfo
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- CN100398119C CN100398119C CNB200510053584XA CN200510053584A CN100398119C CN 100398119 C CN100398119 C CN 100398119C CN B200510053584X A CNB200510053584X A CN B200510053584XA CN 200510053584 A CN200510053584 A CN 200510053584A CN 100398119 C CN100398119 C CN 100398119C
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Abstract
The present invention relates to medicine for improving sleep quality and a preparation method thereof. The medicine is prepared from the following components by weight ratio: 3 to 12 portions of red glossy ganoderma extract, 4 to 13 portions of spine date seed extract, 2 to 8 portions of red sage root extract and 2 to 8 portions of fructus schizandrae extract. The present invention is obtained in a mode that every extract is cleaned and selected to remove impurities, is boiled with water or is heated with ethanol for reflux, etc., and then is extracted and filtered. The medicine of the present invention has the advantages of stable product quality, exact effect and high safety. The medicine of the present invention has the better action of tranquilization and hypnosis, the latent period that mice are asleep can be obviously shortened, and the sleep time of the mice is prolonged. Simultaneously, the time of the autonomic movement of the mice is obviously reduced.
Description
Technical field
The present invention relates to a kind of medicine that improves sleep quality and preparation method thereof.
Background technology
The urbanite often causes insomnia, forgetful, neurasthenia, irritated depressed because of work and life stress.Along with the development of society, the quickening of the life joint Qin, insomnia's incidence rate is on the rise.According to the result of whole world sleep investigation in 2002, the insomnia number accounts for the 40-50% of total number of persons.The actual incidence rate of China's population insomnia is 45.4%, and recognizes that the people who oneself suffers from insomnia has only 25.9%.
Insomnia from the angle of medical science can be divided into difficulty falling asleep, early awakening, easily wake up, dreaminess, sleep table are shallow etc., are unusual complex physical psychological process.Insomnia is found in and violates physiologic factor and environmental factors (work on duty by turns as big evening shift), weather sweltering heat, environment noise and excitement, violates physiological law etc.; The impact of important event, be subjected to emotion and hit and also can cause difficult every night the dormancy; Various internal diseases (as pain, heart disease, asthma etc.) also can cause patient to can't fall asleep evening; Reasons such as mental sickness (as depression, anxiety neurosis), medicine, reviver, climacteric syndrome, sleeping pill improper use also all can cause insomnia.
From angle economic and society, the insomnia problem has all caused serious consequence to individual and society.The a tree name statistics, the direct cost that the U.S. is used for the insomnia nineteen ninety-five is 13,900,000,000 dollars; The direct cost that France is used for the insomnia nineteen ninety-five is 2,000,000,000 dollars.
Concerning the individual, insomnia's main influence is healthy, can feel tired, listless, irritated, anxiety and drowsiness daytime.Insomnia can cause that also sensation changes, and is flat as visual field change, photis, pronunciation.Insomnia makes people's the reduction of decision-making judgement, hypomnesis, and it is all impaired to relate to the coherent brain function of motility, creative thinking, prediction and language.Insomnia also can make and lose one's temper, and behavior is unbridled, and is bigoted, can not be familiar with and admit one's mistake.Insomnia can reduce people's attention, and to the mechanically actuated ability drop, the efficient of the task of finishing the work reduces.Insomnia's indirect cost is also very surprising, and in outpatient service and inpatient, the patient that the insomnia is arranged is about a times of general patient; Insomniac's accident rate is 4.5 times of matched group; There is among the crowd absent from duty insomnia obstacle person to account for 41.4% in work, do not account for and only account for 29% and there is insomnia obstacle person.As long as Sufficient Sleeping, these change recovery at once.
Partly human factor error is thought, as long as replenish the soup proteinaceous nutrient, the loss of few sleep can recover, and in fact, this not only can increase the weight of insomnia, also can cause gastrointestinal dysfunction, obesity and cardiovascular and cerebrovascular disease to take place.
Many insomniacs fear and take the side effect that Western medicine produces, because Western medicine can only induced hypnotic, and poor sleeping quality.Take Western medicine for a long time and more can produce drug resistance, drug effect is descended, side effect such as headache, dizzy, nauseating, constipation, myasthenia can occur.Suddenly drug withdrawal also can make the insomnia aggravation.Some first insomniacs take Western medicine and become long-term insomnia because of fearing.
Summary of the invention
The objective of the invention is to improve the shortcoming of prior art and provide a kind of by natural medium-height grass formulated safe, reliable, have no side effect, have the sedation effect of calming the nerves, can improve the medicine of sleep quality.
Another object of the present invention is to provide a kind of preparation method of this medicine.
For achieving the above object, the present invention filters out the Chinese herbal medicine of transferring the reinforcing the heart liver, having sedation with reference to the modern pharmacological research achievement from motherland's medical treasure-house, by the theory of Chinese medical science prescription, skim the cream off milk, and makes it reach purpose with all worries set aside, that calm the nerves, improve sleep quality.
Medicine of the present invention is to be made by weight by following component:
Red ganoderma extract 3-12 part Semen Ziziphi Spinosae extract 4-13 part
Radix Salviae Miltiorrhizae extract 2-8 part Fructus Schisandrae Chinensis extrat 2-8 part
The method that above-mentioned each component is made medicine of the present invention is as follows:
1. prepare each extract
(1) red ganoderma extract: get qualified red ganoderma medical material, through cleaning, remove impurity, clear water drip washing is clean, chopping, put in the multi-function extractor, add the water that 8-10 doubly measures, boil, extract 3 times, boil extraction time is 0.8-1.2 hour at every turn, and extracting solution filters through 200 eye mesh screens, gets filtrate, in the decompression (80～-95kpa, 65～80 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.05～1.08 (60 ℃ of heat are surveyed), 120 eye mesh screens filter, merge concentrated solution, carry out spray drying, collect spray powder, promptly make the red ganoderma extract.
(2), Semen Ziziphi Spinosae extract: get qualified Semen Ziziphi Spinosae medical material, through cleaning, remove impurity, clear water drip washing is clean, pulverize, put in the Chinese medicine multi-function extractor, add the water that medical material 8-10 doubly measures, boil, extract 3 times, boil extraction time is 0.8-1.2 hour at every turn, and extracting solution filters through 200 eye mesh screens, gets filtrate, in the decompression (80～-95kpa, 65～80 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.05～1.08 (60 ℃ of heat are surveyed), 120 eye mesh screens filter, merge concentrated solution, carry out spray drying, collect spray powder, promptly make Semen Ziziphi Spinosae extract.
(3), Radix Salviae Miltiorrhizae extract: get qualified red rooted salvia,, remove impurity through cleaning, clear water drip washing is clean, and chopping is put in the multi-function extractor, add 80% ethanol that medical material 5-7 doubly measures, heating and refluxing extraction 2 times, each heating and refluxing extraction time respectively is 1.2-1.6 hour, 120 eye mesh screens filter, medicinal residues are standby, merge ethanol extract, decompression recycling ethanol, the merging concentrated solution is alcohol-extracted extract, and is standby; Get the Radix Salviae Miltiorrhizae decoction dregs after the alcohol extraction, add 8-10 times of water gaging, boil and extracted 1-1.2 hour, extracting solution filters through 200 eye mesh screens, gets filtrate, in the decompression (80～-95kpa, 65～80 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.05～1.08 (60 ℃ of heat are surveyed), and 120 eye mesh screens filter, and the merging concentrated solution is a water extracted immersing paste, smoothing out with the fingers tanshinol extracted extract and the water extracted immersing paste merges, carry out spray drying, collect spray powder, promptly make Radix Salviae Miltiorrhizae extract.
(4) Fructus Schisandrae Chinensis extrat: get qualified schisandra chinensis medicinal material,, remove impurity through cleaning, clear water drip washing is clean, pulverizes, and puts in the multi-function extractor, add 80% ethanol that medical material 5-7 doubly measures, heating and refluxing extraction 2 times, each heating and refluxing extraction time respectively is 1.4-1.6 hour, 120 eye mesh screens filter, medicinal residues are standby, merge ethanol extract, decompression recycling ethanol, the merging concentrated solution is alcohol-extracted extract, and is standby; Get the Fructus Schisandrae Chinensis medicinal residues after the alcohol extraction, add 8-10 times of water gaging, boil and extracted 1-1.2 hour, extracting solution filters through 200 eye mesh screens, gets filtrate, in the decompression (80～-95kpa, 65～80 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.05～1.08 (60 ℃ of heat are surveyed), and 120 eye mesh screens filter, and the merging concentrated solution is a water extracted immersing paste, schisandrol extracted extract and the water extracted immersing paste are merged, carry out spray drying, collect spray powder, promptly make Fructus Schisandrae Chinensis extrat.
2, preparation preparation
Take by weighing red ganoderma extract 3-12 part, Semen Ziziphi Spinosae extract 3-12 part, Radix Salviae Miltiorrhizae extract 2-8 part, Fructus Schisandrae Chinensis extrat 2-8 part respectively, each extract is sieved through 60 eye mesh screens, get the qualified raw material that sieves, put mix homogeneously in the mixer, be medicine of the present invention.
The mixed powder that the quality testing of learning from else's experience is qualified carries out capsule charge, and capsule polishing, inspection are gone into bottle, gone into the box packing, promptly get capsule preparations.
Described red ganoderma extract, Semen Ziziphi Spinosae extract, Radix Salviae Miltiorrhizae extract, five thing seed extracts contain that the following mind calming that nourishes blood, nourishing the liver are calmed the nerves, the active component of promoting blood circulation and stopping pain: ganoderan, Ganoderma adenosine, Ganodenic acid, triterpenes, jujuboside, Semen Ziziphi Spinosae flavone, ferulic acid, Semen Ziziphi Spinosae polysaccharide, danshensu, danshensu, Radix Salviae Miltiorrhizae acid, Fructus Schisandrae Chinensis lignanoid, Fructus Schisandrae Chinensis polysaccharide.
Using method (usage and amount): 1-2 time on the 1st, each 2 capsules are used warm water delivery service.
Be suitable for the crowd: be applicable to long-term chronic insomnia personage, often feel that spirit is not enough, feel dizzy, collect worry, restless and need improve sleep crowd's dietetic therapy and prevention and health care.
Composition in the medicine prescription of the present invention has following function: Ganoderma invigorating brain and relieving mental uneasiness, life prolonging; Semen Ziziphi Spinosae, astringing YIN to stop sweating, the mind calming that nourishes blood, nourishing the liver is calmed the nerves; The Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind; The Fructus Schisandrae Chinensis astringing QI promotes the production of body fluid, and the tonification mind protects the liver the kidney invigorating.The full compound recipe composition mind calming that nourishes blood, nourishing the liver is calmed the nerves, and promoting blood circulation and stopping pain protects the liver the function of the kidney invigorating.Have calmness, enhancing immunity, the protection heart reduces oxygen-derived free radicals and lipid peroxide contents, and superoxide dismutase activity improving improves the blood microcirculation, and antiplatelet aggregation reduces blood viscosity, and the control hepatic injury promotes effects such as liver regeneration.
Medicine constant product quality of the present invention, exact efficacy, safe.Experimentation proves: medical instrument of the present invention has sedative-hypnotic effect preferably, can shorten mice significantly and enter the incubation period of sleep and prolong the length of one's sleep of mice, reduces the autonomic activities number of times of mice simultaneously significantly.
Medicine of the present invention had once carried out animal experiment in 2003, now the animal experiment plan of establishment and result are described below:
1, experiment material
1.1 trial drug
Medicine of the present invention (the test products code name section of making a living allays excitement), brown ceramic powder, lot number: ESW03001,
Date of manufacture: 2003.09.10; Provide by Hong Kong Biological Science and Technology Research Inst. Co., Ltd..
Pentobarbital sodium, import packing, China Medicine (Group) Shanghai Chemical Reagent Co.,, lot number: F20020915;
Positive control drug: strange star dream camel bell sheet, defend No. the 413rd, food key word [1997], the strange star company limited in Guangzhou is produced lot number 3001-2;
Deanxit, number of registration: H20020474, Denmark H.Lundbeck A/S-Copenhagen produces, lot number: 1008648;
1.2 experimental animal
The NIH mice is provided by Guangdong Province's Experimental Animal Center, the animal quality certification number: 2002A022;
The experimental situation quality certification: Guangdong probatio inspectionem pecuoarem word 2001C020 number.
1.3 dosage setting
The dosage of medicine of the present invention and positive controls is shown in Table 1
Table 1 is pressed the dosage of body surface area equivalent coefficient conversion medicine of the present invention
Annotate: g represents gram, and kg represents kilogram, and mg represents milliliter down together.
The dosage design considerations:
It is 1g that medicine of the present invention gives the 70kg adult dosage that take every day, and the dose,equivalent that is converted into rat by body surface area is 0.089g/kg, and the dose,equivalent that is converted into mice is 0.129g/kg.
Positive control drug all adopts 3 times of suitable adult's taking dose in contrast: strange star dream camel bell sheet Coming-of-Age Day taking dose is 0.25g, and the dose,equivalent that is converted into mice by body surface area is 0.034g/kg, and 3 multiple doses are 0.100g/kg; Deanxit adult's day taking dose is that 0.25g is 0.032g/kg by the dose,equivalent that body surface area is converted into mice, and 3 multiple doses are 0.096g/kg;
2. experimental technique
2.1 medicine of the present invention is to the pentobarbital sodium influence length of one's sleep
Get 50 of unisexuality NIH mice of body weight 18-22g, be divided into 5 groups at random, it is the blank group, basic, normal, high dosage group of medicine of the present invention and positive controls, every group of 10 mices, first administration before the experiment, the basic, normal, high dosage group mice of medicine wherein of the present invention gastric infusion every day dosage is respectively 0.129g/kg, 0.387g/kg 1.160g/kg is equivalent to 1 times, 3 times 9 times of clinical day taking dose 1g of 70g adult; The blank group is irritated stomach every day and is given normal saline with volume; It is 0.100g/kg that the strange dream camel bell of positive control drug sheet group mice is irritated stomach dosage every day, is equivalent to 3 times of clinical day taking dose 0.26g of 70g adult.Behind the successive administration 30 days, after the last administration 45 minutes, every Mus lumbar injection pentobarbital sodium (50mg/kg), write down respectively then sleeping incubation period of mice and sleep time (with the animal righting reflex loss more than 1 minute for entering the sleep index), the comparable group differences also carried out statistical procedures after experiment finished.
2.2 medicine of the present invention is to the influence of mice autonomic activities
Get 50 of the male NIH mices of body weight 18-22g, be divided into 5 groups at random, it is the blank group, basic, normal, high dosage group of medicine of the present invention and positive controls, every group of 10 mices, first administration before the experiment, the basic, normal, high dosage group mice of medicine wherein of the present invention gastric infusion every day dosage is respectively 0.129g/kg, 0.387g/kg 1.160g/kg is equivalent to 1 times, 3 times 9 times of clinical day taking dose 1g of 70g adult; The blank group is irritated stomach every day and is given normal saline with volume; It is 0.100g/kg that the strange dream camel bell of positive control drug sheet group mice is irritated stomach dosage every day, is equivalent to 3 times of clinical day taking dose 0.26g of 70g adult.Behind the successive administration 30 days, the last administration is after 45 minutes, measures the autonomic activities time of respectively organizing mice, and the autonomic activities number of times in the record mice 5 minutes calculates autonomic activities improvement rate (%); The comparable group differences also carries out statistical procedures.
Autonomic activities improvement rate (%)=(administration group autonomic activities-model group autonomic activities number of times) * 100%
2.3 medicine of the present invention brings out the influence of mice convulsion reaction to pentylenetetrazole
Get 50 of male NIH mice of body weight 18-22g, be divided into 5 groups at random, it is the blank group, basic, normal, high dosage group of medicine of the present invention and positive controls, every group of 10 mices, first administration before the experiment, the basic, normal, high dosage group mice of medicine wherein of the present invention gastric infusion every day dosage is respectively 0.129g/kg, 0.387g/kg, 1.160g/kg, is equivalent to 1 times, 3 times, 9 times of clinical day taking dose 1g of 70g adult; The blank group is irritated stomach every day and is given normal saline with volume; It is 0.096g/kg that positive control drug deanxit group is irritated stomach dosage every day, is equivalent to 3 times of clinical day taking dose 0.25g of 70g adult.Behind the successive administration 30 days, the last administration is after 45 minutes, and the pentylenetetrazole solution of subcutaneous injection threshold dose is index clonism to occur, and each organizes the number of animals that convulsions takes place record, the incubation period that record is fainted from fear and reacted; Calculate convulsion rate (%); The comparable group differences also carries out statistical procedures.
Convulsion rate (%)=administration group convulsions number of animals/blank group occurs and convulsions number of animals * 100% occurs
3. experimental result
3.1 medicine of the present invention is to the pentobarbital sodium influence length of one's sleep
Medicine of the present invention to mouse peritoneal injection pentobarbital sodium after the effect of the length of one's sleep be shown in Table 2.
Table 2 medicine of the present invention to pentobarbital sodium mouse sleep time influence (X ± SD, n=10)
| Group | Dosage g/kg | Sleep incubation period of mice minute | Mouse sleep time minute |
| The blank group | NS | 9.6±3.9 | 21.9±5.7 |
| Medicine low dose group of the present invention | 0.129 | 7.1±3.6 △ | 55.4±20.2*** |
| Dosage group in the medicine of the present invention | 0.387 | 6.2±2.3* | 66.3±23.9*** |
| Medicine high dose group of the present invention | 1.160 | 5.4±1.5** | 87.5±32.1*** |
| Strange star dream camel bell matched group | 0.100 | 4.9±2.6** | 65.1±20.6*** |
Compare with the blank group,
*P＜0.05,
*P＜0.01,
* *P＜0.001,
△P＞0.05
Can get by experimental result, medicine of the present invention can shorten the incubation period that mice advances sleep, simultaneously prolonged the length of one's sleep of mice again significantly, above-mentioned two indexs of the basic, normal, high dosage group of medicine of the present invention with the same period blank group compare and have significant difference (P＜0.05, P＜0.01P＜0.001); Medicine of the present invention and pentobarbital sodium have good synergism, tentatively point out medical instrument of the present invention that sedative-hypnotic effect is preferably arranged.The strange star dream of positive control drug camel bell sheet group has significant difference (P＜0.01, P＜0.001), and under identical multiple, its action effect slightly is better than the middle dosage group of medicine of the present invention.
3.2 medicine of the present invention is to the influence of mice autonomic activities
Medicine successive administration of the present invention after 30 days the pharmacological action to mice be shown in Table 3.
Table 3 medicine of the present invention to the autonomic activities test result of mice (X ± SD, n=10)
| Group | Dosage g/kg | The autonomic activities number of times (n) of 5min mice |
| The blank group | NS | 252±40 |
| Medicine low dose group of the present invention | 0.129 | 205±38 * |
| Dosage group in the medicine of the present invention | 0.387 | 196±40 ** |
| Medicine high dose group of the present invention | 1.160 | 176±28 *** |
| Strange star dream camel bell matched group | 0.100 | 189±44 ** |
Compare with the blank group,
*P＜0.05,
*P＜0.01,
* *P＜0.001,
△P＞0.05
Can be got by experimental result, the basic, normal, high dosage group of medicine of the present invention can reduce the autonomic activities number of times in the mice 5 minutes, with the same period blank group compare and have significant difference (P＜0.05, P＜0.01P＜0.001); Have certain dose-effect relationship between each dosage group, the autonomic activities number of times of positive control mice descends, and compares with the blank group to have significant difference (P＜0.01), and the middle dosage group of its action effect and medicine of the present invention is close.
3.3 medicine of the present invention brings out the influence of mice convulsion reaction to pentylenetetrazole
Medicine successive administration of the present invention is after 30 days, and the subcutaneous injection pentylenetetrazole brings out the results are shown in Table shown in 4 of mice convulsion reaction.
Table 4 medicine pentylenetetrazole of the present invention bring out mice convulsion reaction pharmacological action (X ± SD, n=10)
| Group | Dosage g/kg | Mice against seizure number (n) | Convulsions number (%) | The mice against seizure response latency (S) |
| The blank group | NS | 10 | 100 | 80.7±17.7 |
| Medicine low dose group of the present invention | 0.129 | 9 | 90 | 83.7±22.2 △ |
| Dosage group in the medicine of the present invention | 0.387 | 8 | 80 | 90.5±19.0 △ |
| Medicine high dose group of the present invention | 1.160 | 8 | 80 | 90.4±19.9 △ |
| Strange star dream camel bell matched group | 0.100 | 6 | 60 | 123.9±29.4 *** |
Compare with the blank group,
*P＜0.05,
*P＜0.01,
* *P＜0.001,
△P＞0.05
Can get by experimental result, though each dosage group mice of medicine of the present invention is reduced by the mice number that pentylenetetrazole brings out the reaction of fainting from fear, slightly prolong the incubation period of mice convulsion reaction, but with the same period blank group compare, difference that there are no significant (P＜0.05), the anticonvulsant action that medicine of the present invention is described is also not obvious, positive control drug deanxit group mice against seizure rate is 60%, can prolong the response latency of fainting from fear, compare with the blank group and to have significant difference (P＜0.001), point out its tool anticonvulsant action preferably.
4, experiment conclusion
Comprehensive above-mentioned experimental result as can be known, the basic, normal, high dosage group of medicine of the present invention all has sedative-hypnotic effect preferably, can shorten mice significantly enters the incubation period of sleep and prolongs the length of one's sleep of mice, simultaneously reduce the autonomic activities number of times of mice significantly, but each dosage group of medicine of the present invention does not all show anticonvulsant action.
The specific embodiment
Embodiment 1:
Medicine of the present invention is to be made by weight by following component:
4 parts of 3 parts of Semen Ziziphi Spinosae extracts of red ganoderma extract
2 parts of 2 parts of Fructus Schisandrae Chinensis extrats of Radix Salviae Miltiorrhizae extract
The method that above-mentioned each component is made medicine of the present invention is as follows:
1. prepare each extract
(1) red ganoderma extract: get qualified red ganoderma medical material, through cleaning, remove impurity, clear water drip washing is clean, chopping, put in the multi-function extractor, add the water of 8 times of amounts, boil, extract 3 times, boil extraction time is 0.8 hour at every turn, and extracting solution filters through 200 eye mesh screens, gets filtrate, in decompression (80kpa, 65 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.05 (60 ℃ of heat are surveyed), 120 eye mesh screens filter, merge concentrated solution, carry out spray drying, collect spray powder, promptly make the red ganoderma extract.
(2), Semen Ziziphi Spinosae extract: get qualified Semen Ziziphi Spinosae medical material, through cleaning, remove impurity, clear water drip washing is clean, pulverize, put in the Chinese medicine multi-function extractor, add the water of 8 times of amounts of medical material, boil, extract 3 times, boil extraction time is 0.8 hour at every turn, and extracting solution filters through 200 eye mesh screens, gets filtrate, in decompression (80kpa, 65 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.05 (60 ℃ of heat are surveyed), 120 eye mesh screens filter, merge concentrated solution, carry out spray drying, collect spray powder, promptly make Semen Ziziphi Spinosae extract.
(3), Radix Salviae Miltiorrhizae extract: get qualified red rooted salvia,, remove impurity through cleaning, clear water drip washing is clean, and chopping is put in the multi-function extractor, 80% ethanol that adds 5 times of amounts of medical material, heating and refluxing extraction 2 times, each heating and refluxing extraction time respectively is 1.2 hours, 120 eye mesh screens filter, medicinal residues are standby, merge ethanol extract, decompression recycling ethanol, the merging concentrated solution is alcohol-extracted extract, and is standby; Get the Radix Salviae Miltiorrhizae decoction dregs after the alcohol extraction, add 8 times of water gagings, boil and extracted 1-hour, extracting solution filters through 200 eye mesh screens, gets filtrate, in decompression (80kpa, 65 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.05 (60 ℃ of heat are surveyed), and 120 eye mesh screens filter, and the merging concentrated solution is a water extracted immersing paste, tanshinol extracted extract and the water extracted immersing paste are merged, carry out spray drying, collect spray powder, promptly make Radix Salviae Miltiorrhizae extract.
(4) Fructus Schisandrae Chinensis extrat: get qualified schisandra chinensis medicinal material,, remove impurity through cleaning, clear water drip washing is clean, pulverizes, and puts in the multi-function extractor, 80% ethanol that adds 5 times of amounts of medical material, heating and refluxing extraction 2 times, each heating and refluxing extraction time respectively is 1.4 hours, 120 eye mesh screens filter, medicinal residues are standby, merge ethanol extract, decompression recycling ethanol, the merging concentrated solution is alcohol-extracted extract, and is standby; Get the Fructus Schisandrae Chinensis medicinal residues after the alcohol extraction, add 8 times of water gagings, boil and extracted 1 hour, extracting solution filters through 200 eye mesh screens, gets filtrate, in decompression (80kpa, 65 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.05 (60 ℃ of heat are surveyed), and 120 eye mesh screens filter, and the merging concentrated solution is a water extracted immersing paste, schisandrol extracted extract and the water extracted immersing paste are merged, carry out spray drying, collect spray powder, promptly make Fructus Schisandrae Chinensis extrat.
2, preparation preparation
Take by weighing 3 parts of red ganoderma extracts, 4 parts of Semen Ziziphi Spinosae extracts, 2 parts of Radix Salviae Miltiorrhizae extracts, 2 parts of Fructus Schisandrae Chinensis extrats respectively, each extract is sieved through 60 eye mesh screens, get the qualified raw material that sieves, put mix homogeneously in the mixer, be medicine of the present invention.
The mixed powder that the quality testing of learning from else's experience is qualified carries out capsule charge, and capsule polishing, inspection are gone into bottle, gone into the box packing, promptly get capsule preparations.
Embodiment 2:
Medicine of the present invention is to be made by weight by following component:
13 parts of 12 parts of Semen Ziziphi Spinosae extracts of red ganoderma extract
8 parts of 8 parts of Fructus Schisandrae Chinensis extrats of Radix Salviae Miltiorrhizae extract
The method that above-mentioned each component is made medicine of the present invention is as follows:
1. prepare each extract
(1) red ganoderma extract: get qualified red ganoderma medical material, through cleaning, remove impurity, clear water drip washing is clean, chopping, put in the multi-function extractor, add the water of 10 times of amounts, boil, extract 3 times, boil extraction time is 1.2 hours at every turn, and extracting solution filters through 200 eye mesh screens, gets filtrate, in decompression (95kpa, 80 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.08 (60 ℃ of heat are surveyed), 120 eye mesh screens filter, merge concentrated solution, carry out spray drying, collect spray powder, promptly make the red ganoderma extract.
(2), Semen Ziziphi Spinosae extract: get qualified Semen Ziziphi Spinosae medical material, through cleaning, remove impurity, clear water drip washing is clean, pulverize, put in the Chinese medicine multi-function extractor, add the water of 10 times of amounts of medical material, boil, extract 3 times, boil extraction time is 1.2 hours at every turn, and extracting solution filters through 200 eye mesh screens, gets filtrate, in decompression (95kpa, 80 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.08 (60 ℃ of heat are surveyed), 120 eye mesh screens filter, merge concentrated solution, carry out spray drying, collect spray powder, promptly make Semen Ziziphi Spinosae extract.
(3), Radix Salviae Miltiorrhizae extract: get qualified red rooted salvia,, remove impurity through cleaning, clear water drip washing is clean, and chopping is put in the multi-function extractor, 80% ethanol that adds 7 times of amounts of medical material, heating and refluxing extraction 2 times, each heating and refluxing extraction time respectively is 1.6 hours, 120 eye mesh screens filter, medicinal residues are standby, merge ethanol extract, decompression recycling ethanol, the merging concentrated solution is alcohol-extracted extract, and is standby; Get the Radix Salviae Miltiorrhizae decoction dregs after the alcohol extraction, add 10 times of water gagings, boil and extracted 1.2 hours, extracting solution filters through 200 eye mesh screens, gets filtrate, in decompression (95kpa, 80 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.08 (60 ℃ of heat are surveyed), and 120 eye mesh screens filter, and the merging concentrated solution is a water extracted immersing paste, tanshinol extracted extract and the water extracted immersing paste are merged, carry out spray drying, collect spray powder, promptly make Radix Salviae Miltiorrhizae extract.
(4) Fructus Schisandrae Chinensis extrat: get qualified schisandra chinensis medicinal material,, remove impurity through cleaning, clear water drip washing is clean, pulverizes, and puts in the multi-function extractor, 80% ethanol that adds 7 times of amounts of medical material, heating and refluxing extraction 2 times, each heating and refluxing extraction time respectively is 1.6 hours, 120 eye mesh screens filter, medicinal residues are standby, merge ethanol extract, decompression recycling ethanol, the merging concentrated solution is alcohol-extracted extract, and is standby; Get the Fructus Schisandrae Chinensis medicinal residues after the alcohol extraction, add 10 times of water gagings, boil and extracted 1.2 hours, extracting solution filters through 200 eye mesh screens, gets filtrate, in decompression (95kpa, 80 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.08 (60 ℃ of heat are surveyed), and 120 eye mesh screens filter, and the merging concentrated solution is a water extracted immersing paste, schisandrol extracted extract and the water extracted immersing paste are merged, carry out spray drying, collect spray powder, promptly make Fructus Schisandrae Chinensis extrat.
2, preparation preparation
Take by weighing 12 parts of red ganoderma extracts, 13 parts of Semen Ziziphi Spinosae extracts, 8 parts of Radix Salviae Miltiorrhizae extracts, 8 parts of Fructus Schisandrae Chinensis extrats respectively, each extract is sieved through 60 eye mesh screens, get the qualified raw material that sieves, put mix homogeneously in the mixer, be medicine of the present invention.
The mixed powder that the quality testing of learning from else's experience is qualified carries out capsule charge, and capsule polishing, inspection are gone into bottle, gone into the box packing, promptly get capsule preparations.
Embodiment 3:
Medicine of the present invention is to be made by weight by following component:
9 parts of 7 parts of Semen Ziziphi Spinosae extracts of red ganoderma extract
6 parts of 5 parts of Fructus Schisandrae Chinensis extrats of Radix Salviae Miltiorrhizae extract
The method that above-mentioned each component is made medicine of the present invention is as follows:
1. prepare each extract
(1) red ganoderma extract: get qualified red ganoderma medical material, through cleaning, remove impurity, clear water drip washing is clean, chopping, put in the multi-function extractor, add the water of 9 times of amounts, boil, extract 3 times, boil extraction time is 1 hour at every turn, and extracting solution filters through 200 eye mesh screens, gets filtrate, in decompression (90kpa, 70 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.07 (60 ℃ of heat are surveyed), 120 eye mesh screens filter, merge concentrated solution, carry out spray drying, collect spray powder, promptly make the red ganoderma extract.
(2), Semen Ziziphi Spinosae extract: get qualified Semen Ziziphi Spinosae medical material, through cleaning, remove impurity, clear water drip washing is clean, pulverize, put in the Chinese medicine multi-function extractor, add the water of 9 times of amounts of medical material, boil, extract 3 times, boil extraction time is 1 hour at every turn, and extracting solution filters through 200 eye mesh screens, gets filtrate, in decompression (90kpa, 70 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.07 (60 ℃ of heat are surveyed), 120 eye mesh screens filter, merge concentrated solution, carry out spray drying, collect spray powder, promptly make Semen Ziziphi Spinosae extract.
(3), Radix Salviae Miltiorrhizae extract: get qualified red rooted salvia,, remove impurity through cleaning, clear water drip washing is clean, and chopping is put in the multi-function extractor, 80% ethanol that adds 6 times of amounts of medical material, heating and refluxing extraction 2 times, each heating and refluxing extraction time respectively is 1.4 hours, 120 eye mesh screens filter, medicinal residues are standby, merge ethanol extract, decompression recycling ethanol, the merging concentrated solution is alcohol-extracted extract, and is standby; Get the Radix Salviae Miltiorrhizae decoction dregs after the alcohol extraction, add 9 times of water gagings, boil and extracted 1.1 hours, extracting solution filters through 200 eye mesh screens, gets filtrate, in decompression (90kpa, 70 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.07 (60 ℃ of heat are surveyed), and 120 eye mesh screens filter, and the merging concentrated solution is a water extracted immersing paste, tanshinol extracted extract and the water extracted immersing paste are merged, carry out spray drying, collect spray powder, promptly make Radix Salviae Miltiorrhizae extract.
(4) Fructus Schisandrae Chinensis extrat: get qualified schisandra chinensis medicinal material,, remove impurity through cleaning, clear water drip washing is clean, pulverizes, and puts in the multi-function extractor, 80% ethanol that adds 6 times of amounts of medical material, heating and refluxing extraction 2 times, each heating and refluxing extraction time respectively is 1.5 hours, 120 eye mesh screens filter, medicinal residues are standby, merge ethanol extract, decompression recycling ethanol, the merging concentrated solution is alcohol-extracted extract, and is standby; Get the Fructus Schisandrae Chinensis medicinal residues after the alcohol extraction, add 9 times of water gagings, boil and extracted 1.1 hours, extracting solution filters through 200 eye mesh screens, gets filtrate, in decompression (90kpa, 70 ℃) under the condition, being concentrated into relative density is the concentrated solution of 1.07 (60 ℃ of heat are surveyed), and 120 eye mesh screens filter, and the merging concentrated solution is a water extracted immersing paste, schisandrol extracted extract and the water extracted immersing paste are merged, carry out spray drying, collect spray powder, promptly make Fructus Schisandrae Chinensis extrat.
2, preparation preparation
Take by weighing 7 parts of red ganoderma extracts, 9 parts of Semen Ziziphi Spinosae extracts, 5 parts of Radix Salviae Miltiorrhizae extracts, 6 parts of Fructus Schisandrae Chinensis extrats respectively, each extract is sieved through 60 eye mesh screens, get the qualified raw material that sieves, put mix homogeneously in the mixer, be medicine of the present invention.
The mixed powder that the quality testing of learning from else's experience is qualified carries out capsule charge, and capsule polishing, inspection are gone into bottle, gone into the box packing, promptly get capsule preparations.
Claims (2)
1. one kind is improved medicine of sleep quality and preparation method thereof, it is characterized in that: it is to be made by weight by following component:
Water extract 3-12 part of red ganoderma, water extract 4-13 part of Semen Ziziphi Spinosae,
Mixture 2-8 part of the alcohol-extracted extract of Radix Salviae Miltiorrhizae and the water extracted immersing paste,
Mixture 2-8 part of the alcohol-extracted extract of Fructus Schisandrae Chinensis and the water extracted immersing paste.
2. a kind of preparation method of improving the sleep quality medicine as claimed in claim 1 is characterized in that:
A, prepare each extract
(1) water extract of red ganoderma: get qualified red ganoderma medical material, through cleaning, remove impurity, clear water drip washing is clean, chopping, put in the multi-function extractor, add the water that 8-10 doubly measures, boil, extract 3 times, boil extraction time is 0.8-1.2 hour at every turn, and extracting solution filters through 200 eye mesh screens, gets filtrate, in pressure-80～-95kpa, under the reduced pressure that temperature is 65～80 ℃, being concentrated into that 60 ℃ of relative densities heat surveys is 1.05～1.08 concentrated solution, and 120 eye mesh screens filter, merge concentrated solution, carry out spray drying, collect spray powder, promptly make the water extract of red ganoderma;
(2), the water extract of Semen Ziziphi Spinosae: get qualified Semen Ziziphi Spinosae medical material, through cleaning, remove impurity, clear water drip washing is clean, pulverize, put in the Chinese medicine multi-function extractor, add the water that medical material 8-10 doubly measures, boil, extract 3 times, boil extraction time is 0.8-1.2 hour at every turn, and extracting solution filters through 200 eye mesh screens, gets filtrate, in pressure-80～-95kpa, under the reduced pressure that temperature is 65～80 ℃, being concentrated into that 60 ℃ of relative densities heat surveys is 1.05～1.08 concentrated solution, and 120 eye mesh screens filter, merge concentrated solution, carry out spray drying, collect spray powder, promptly make the water extract of Semen Ziziphi Spinosae;
(3), the alcohol-extracted extract of Radix Salviae Miltiorrhizae and the mixture of the water extracted immersing paste: get qualified red rooted salvia,, remove impurity through cleaning, clear water drip washing is clean, and chopping is put in the multi-function extractor, add 80% ethanol that medical material 5-7 doubly measures, heating and refluxing extraction 2 times, each heating and refluxing extraction time respectively is 1.2-1.6 hour, 120 eye mesh screens filter, medicinal residues are standby, merge ethanol extract, decompression recycling ethanol, the merging concentrated solution is alcohol-extracted extract, and is standby; Get the Radix Salviae Miltiorrhizae decoction dregs after the alcohol extraction, add 8-10 times of water gaging, boil and extracted 1-1.2 hour, extracting solution filters through 200 eye mesh screens, gets filtrate, in pressure-80～-95kpa, under the reduced pressure that temperature is 65～80 ℃, being concentrated into that 60 ℃ of relative densities heat surveys is 1.05～1.08 concentrated solution, and 120 eye mesh screens filter, and the merging concentrated solution is a water extracted immersing paste, tanshinol extracted extract and the water extracted immersing paste are merged, carry out spray drying, collect spray powder, promptly make the alcohol-extracted extract of Radix Salviae Miltiorrhizae and the mixture of the water extracted immersing paste;
(4) mixture of the alcohol-extracted extract of Fructus Schisandrae Chinensis and the water extracted immersing paste: get qualified schisandra chinensis medicinal material,, remove impurity through cleaning, clear water drip washing is clean, pulverizes, and puts in the multi-function extractor, add 80% ethanol that medical material 5-7 doubly measures, heating and refluxing extraction 2 times, each heating and refluxing extraction time respectively is 1.4-1.6 hour, 120 eye mesh screens filter, medicinal residues are standby, merge ethanol extract, decompression recycling ethanol, the merging concentrated solution is alcohol-extracted extract, and is standby; Get the Fructus Schisandrae Chinensis medicinal residues after the alcohol extraction, add 8-10 times of water gaging, boil and extracted 1-1.2 hour, extracting solution filters through 200 eye mesh screens, gets filtrate, in pressure-80～-95kpa, under 65～80 ℃ of conditions of temperature, being concentrated into that 60 ℃ of relative densities heat surveys is 1.05～1.08 concentrated solution, and 120 eye mesh screens filter, and the merging concentrated solution is a water extracted immersing paste, schisandrol extracted extract and the water extracted immersing paste are merged, carry out spray drying, collect spray powder, promptly make the alcohol-extracted extract of Fructus Schisandrae Chinensis and the mixture of the water extracted immersing paste;
B, preparation preparation
Take by weighing water extract 3-12 part of red ganoderma, water extract 3-12 part of Semen Ziziphi Spinosae, alcohol-extracted extract and mixture 2-8 part of the water extracted immersing paste, the alcohol-extracted extract of Fructus Schisandrae Chinensis and mixture 2-8 part of the water extracted immersing paste of Radix Salviae Miltiorrhizae respectively, each extract is sieved through 60 eye mesh screens, get the qualified raw material that sieves, put mix homogeneously in the mixer, be medicine of the present invention.
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| CN103340407A (en) * | 2013-07-23 | 2013-10-09 | 四川省中医药科学院 | Composition with sleep improving effect as well as preparation method and use of composition |
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| CN104138450B (en) * | 2014-08-07 | 2016-08-03 | 广州医科大学附属第一医院 | For treating cough and alleviating the Fructus Schisandrae Chinensis extrat of airway inflammation, its preparation method and application |
| CN104223066A (en) * | 2014-09-02 | 2014-12-24 | 上海焦点生物技术有限公司 | Traditional Chinese medicine composition for improving sleeping |
| CN110960586B (en) * | 2019-12-31 | 2022-04-15 | 南京中山制药有限公司 | Ant sleeping-aid capsule and its preparation method |
| CN112649536A (en) * | 2020-12-31 | 2021-04-13 | 北京康立生医药技术开发有限公司 | Method for detecting functional components of composition |
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| CN1390590A (en) * | 2002-06-20 | 2003-01-15 | 成都康弘制药有限公司 | Health-care food for improving sleep |
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| CN1390590A (en) * | 2002-06-20 | 2003-01-15 | 成都康弘制药有限公司 | Health-care food for improving sleep |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103340407A (en) * | 2013-07-23 | 2013-10-09 | 四川省中医药科学院 | Composition with sleep improving effect as well as preparation method and use of composition |
| CN103340407B (en) * | 2013-07-23 | 2015-07-22 | 四川省中医药科学院 | Composition with sleep improving effect as well as preparation method and use of composition |
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