CN100391480C - Hydrophilic gel pleximetric paste and its preparation - Google Patents
Hydrophilic gel pleximetric paste and its preparation Download PDFInfo
- Publication number
- CN100391480C CN100391480C CNB2006100192327A CN200610019232A CN100391480C CN 100391480 C CN100391480 C CN 100391480C CN B2006100192327 A CNB2006100192327 A CN B2006100192327A CN 200610019232 A CN200610019232 A CN 200610019232A CN 100391480 C CN100391480 C CN 100391480C
- Authority
- CN
- China
- Prior art keywords
- hydrophilic gel
- gel
- pleximetric
- volatile oil
- radix bupleuri
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000002360 preparation method Methods 0.000 title claims description 11
- 239000000499 gel Substances 0.000 claims abstract description 71
- 239000000341 volatile oil Substances 0.000 claims abstract description 47
- 239000002904 solvent Substances 0.000 claims abstract description 18
- 239000000853 adhesive Substances 0.000 claims abstract description 17
- 230000001070 adhesive effect Effects 0.000 claims abstract description 17
- 239000004094 surface-active agent Substances 0.000 claims abstract description 16
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 15
- 239000000945 filler Substances 0.000 claims abstract description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 27
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- 230000000149 penetrating effect Effects 0.000 claims description 16
- 239000000080 wetting agent Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 9
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 8
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 8
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 8
- 239000004745 nonwoven fabric Substances 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 6
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 5
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 5
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 5
- 108010010803 Gelatin Proteins 0.000 claims description 5
- 239000005642 Oleic acid Substances 0.000 claims description 5
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 5
- 239000000470 constituent Substances 0.000 claims description 5
- 239000008273 gelatin Substances 0.000 claims description 5
- 229920000159 gelatin Polymers 0.000 claims description 5
- 235000019322 gelatine Nutrition 0.000 claims description 5
- 235000011852 gelatine desserts Nutrition 0.000 claims description 5
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 5
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 5
- 229920000136 polysorbate Polymers 0.000 claims description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
- BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical compound O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 claims description 4
- 239000004202 carbamide Substances 0.000 claims description 4
- 235000013877 carbamide Nutrition 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 2
- HXFCUMCLVYNZDM-UHFFFAOYSA-N 2-aminoacetic acid;sodium Chemical compound [Na].NCC(O)=O HXFCUMCLVYNZDM-UHFFFAOYSA-N 0.000 claims description 2
- 239000005995 Aluminium silicate Substances 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- 229910021502 aluminium hydroxide Inorganic materials 0.000 claims description 2
- 235000012211 aluminium silicate Nutrition 0.000 claims description 2
- 239000000440 bentonite Substances 0.000 claims description 2
- 229910000278 bentonite Inorganic materials 0.000 claims description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 2
- 229940025250 camphora Drugs 0.000 claims description 2
- 239000010238 camphora Substances 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 239000010642 eucalyptus oil Substances 0.000 claims description 2
- 229940044949 eucalyptus oil Drugs 0.000 claims description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000003921 oil Substances 0.000 claims description 2
- 150000007524 organic acids Chemical class 0.000 claims description 2
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 239000004408 titanium dioxide Substances 0.000 claims description 2
- 239000011787 zinc oxide Substances 0.000 claims description 2
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229960003511 macrogol Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 6
- 241000202726 Bupleurum Species 0.000 abstract description 3
- 239000003906 humectant Substances 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 description 14
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 238000011160 research Methods 0.000 description 7
- 206010002198 Anaphylactic reaction Diseases 0.000 description 6
- 208000003455 anaphylaxis Diseases 0.000 description 6
- 230000036760 body temperature Effects 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 239000001307 helium Substances 0.000 description 6
- 229910052734 helium Inorganic materials 0.000 description 6
- -1 helium ketone Chemical class 0.000 description 6
- 230000036783 anaphylactic response Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 210000000436 anus Anatomy 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- 239000004744 fabric Substances 0.000 description 4
- 206010022000 influenza Diseases 0.000 description 4
- 239000002510 pyrogen Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000001647 drug administration Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000011975 tartaric acid Substances 0.000 description 3
- 235000002906 tartaric acid Nutrition 0.000 description 3
- 241000510654 Bupleurum chinense Species 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- 239000003125 aqueous solvent Substances 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000013270 controlled release Methods 0.000 description 2
- 230000002951 depilatory effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000003746 feather Anatomy 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 229920002556 Polyethylene Glycol 300 Polymers 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 210000003314 quadriceps muscle Anatomy 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
Description
Claims (8)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100192327A CN100391480C (en) | 2006-05-31 | 2006-05-31 | Hydrophilic gel pleximetric paste and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100192327A CN100391480C (en) | 2006-05-31 | 2006-05-31 | Hydrophilic gel pleximetric paste and its preparation |
Publications (2)
Publication Number | Publication Date |
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CN1895311A CN1895311A (en) | 2007-01-17 |
CN100391480C true CN100391480C (en) | 2008-06-04 |
Family
ID=37608049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CNB2006100192327A Active CN100391480C (en) | 2006-05-31 | 2006-05-31 | Hydrophilic gel pleximetric paste and its preparation |
Country Status (1)
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CN (1) | CN100391480C (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101919829A (en) * | 2010-09-06 | 2010-12-22 | 西北大学 | Hydrogel cataplasm for microneedle cutaneous penetration and preparation method thereof |
CN103349658A (en) * | 2013-07-02 | 2013-10-16 | 贵州省遵义市苗风医药保健品有限公司 | Bridge-type hydrogel emplastrum |
CN103356723B (en) * | 2013-08-07 | 2015-06-03 | 河南中医学院 | Cooling paste for children and preparation method thereof |
CN104367940B (en) * | 2014-10-28 | 2017-09-12 | 无锡济民可信山禾药业股份有限公司 | A kind of microneedle cutaneous system of compound Chinese medicinal preparation |
CN106606566A (en) * | 2016-12-01 | 2017-05-03 | 湖北硅金凝节能减排科技有限公司 | Gel patch for treating skin itching, and preparation method thereof |
CN112957265B (en) * | 2021-02-25 | 2023-04-25 | 郑州依莱恩生物科技有限公司 | Hydrophilic gel with good permeability and controllable permeation time and preparation method thereof |
CN114886981B (en) * | 2022-05-12 | 2023-08-29 | 杭州市萧山区中医院 | Traditional Chinese medicine composition and application thereof in preparation of neck-shoulder lumbocrural pain medicines |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1273819A (en) * | 2000-05-16 | 2000-11-22 | 刘安西 | Release-controlled Chinese-medicinal picking for reducing baby fever caused by cold |
CN1562183A (en) * | 2004-03-17 | 2005-01-12 | 北京奇源益德药物研究所 | Chinese medica preparation for curing hyperplasia of mammary glands and preparation method |
CN1742980A (en) * | 2005-10-01 | 2006-03-08 | 南宁市第一人民医院 | Chinese medicinal lotion for new-borne baby's removing jaundice |
-
2006
- 2006-05-31 CN CNB2006100192327A patent/CN100391480C/en active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1273819A (en) * | 2000-05-16 | 2000-11-22 | 刘安西 | Release-controlled Chinese-medicinal picking for reducing baby fever caused by cold |
CN1562183A (en) * | 2004-03-17 | 2005-01-12 | 北京奇源益德药物研究所 | Chinese medica preparation for curing hyperplasia of mammary glands and preparation method |
CN1742980A (en) * | 2005-10-01 | 2006-03-08 | 南宁市第一人民医院 | Chinese medicinal lotion for new-borne baby's removing jaundice |
Non-Patent Citations (2)
Title |
---|
球面对称设计法优化乳安贴剂基质及促进剂. 王云彩等.中国药师,第5卷第4期. 2002 |
球面对称设计法优化乳安贴剂基质及促进剂. 王云彩等.中国药师,第5卷第4期. 2002 * |
Also Published As
Publication number | Publication date |
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CN1895311A (en) | 2007-01-17 |
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Effective date of registration: 20081212 Address after: Guangdong province Zhuhai Sanzao Science Park Airport Road No. 697 Patentee after: Zhuhai State-kai Polymer and New Materials Co., Ltd. Address before: Wuhan Wuhan Heigl science and Technology Co., Ltd., No. 105, bumper harvest village, Hubei gate, Wuchang District, Sichuan Province Patentee before: WuHan Highgear Science & Technology Co., Ltd |
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Owner name: ZHUHAI GUOJIA MACROMOLECULE NEW MATERIALS CO., LTD Free format text: FORMER OWNER: WUHAN CITY HAIGEER TECHNOLOGY CO., LTD. Effective date: 20081212 |
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Owner name: ZHUHAI GUOJIA NEW MATERIALS CO., LTD. Free format text: FORMER NAME: ZHUHAI STATE-KAI POLYMER AND NEW MATERIALS CO., LTD. |
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CP01 | Change in the name or title of a patent holder |
Address after: 519020 Guangdong province Zhuhai Sanzao Science Park Airport Road No. 697 Patentee after: ZHUHAI GUOJIA NEW MATERIAL CO., LTD. Address before: 519020 Guangdong province Zhuhai Sanzao Science Park Airport Road No. 697 Patentee before: Zhuhai State-kai Polymer and New Materials Co., Ltd. |
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Effective date of registration: 20160422 Address after: Longyang Road 430050 Hubei city of Wuhan province Kangda street Hanyang District No. 5 Patentee after: Bingbing Pharmaceutical Co., Ltd., Wuhan Address before: 519020 Guangdong province Zhuhai Sanzao Science Park Airport Road No. 697 Patentee before: ZHUHAI GUOJIA NEW MATERIAL CO., LTD. |
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CP03 | Change of name, title or address | ||
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Address after: 442000 No. 698 Bingbing Road, Yunyang Economic Development Zone, Shiyan City, Hubei Province Patentee after: Hubei Bingbing Pharmaceutical Industry (Group) Co., Ltd. Address before: Longyang Road 430050 Hubei city of Wuhan province Kangda street Hanyang District No. 5 Patentee before: Bingbing Pharmaceutical Co., Ltd., Wuhan |