CN102218074B - Transdermal patch containing paeoniflorin and glycyrrhetinic acid and method for preparing same - Google Patents
Transdermal patch containing paeoniflorin and glycyrrhetinic acid and method for preparing same Download PDFInfo
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- CN102218074B CN102218074B CN2011101840489A CN201110184048A CN102218074B CN 102218074 B CN102218074 B CN 102218074B CN 2011101840489 A CN2011101840489 A CN 2011101840489A CN 201110184048 A CN201110184048 A CN 201110184048A CN 102218074 B CN102218074 B CN 102218074B
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Abstract
The invention discloses composition of a paeoniflorin- glycyrrhetinic acid transdermal patch and a method for preparing the same. The transdermal patch consists of a lining, a drug-carrying pressure sensitive adhesive layer and an anti-sticking layer, wherein the drug-carrying pressure sensitive adhesive layer comprises the following ingredients in part by weight: 1 to 20 parts of paeoniflorin and 1 to 20 parts of glycyrrhetinic acid or 5 to 30 parts of extract of paeoniflorin and 5 to 30 parts of extract of glycyrrhetinic acid, organic alkali, a penetration enhancer and butyl alcohol. The content of the paeoniflorin of the extract of paeoniflorin and the content of the glycyrrhetinic acid of the extract of glycyrrhetinic acid are 20 to 90 percent respectively. The main active ingredients of common peony and liquorice can enter skin and subcutaneous tissues by transdermal penetration to effectively alleviate and inhibit spasm and pain in local tissues.
Description
Technical field
The present invention relates to medical technical field, a kind of transdermal drug delivery system that suppresses monospasm and pain that can be used in is provided, be specially the transdermal patch and the method for preparing that contain peoniflorin and enoxolone.
Background technology
Peony and licorice decoction comes from treatise on Febrile Diseases one book, is that Zhong Jing is a typhoid fever mistake antiperspirant YANG-depletion, and the multiple back of sun muscle spasm of the leg and foot is demonstrate,proved and established.In recent years, peony and licorice decoction is widely used in internal medicine, surgery, gynecological and multiple pain card, dialectically uses it, satisfactory effect according to modern pharmacological research.
Peony and licorice decoction administered through oral administration traditionally, its determined curative effect has pharmacological action to uterine smooth muscle, gastrointestinal tract; But and antalgic and inflammation relieving, antiallergic, relieving cough and asthma and tool amphicheirality regulating action; Of many uses, but dosage is big, causes the intestines and stomach to stimulate; Untoward reaction such as hypertension and pseudo-aldosterone disease, bioavailability is lower.Adopt percutaneous dosing can avoid the intestines and stomach and liver first-pass effect in theory, effective ingredient not only can be directly to and reaches the local target tissue of subcutaneous deep layer, brings into play its local directly effect, can get into blood circulation performance general action through subcutaneous blood capillary again.Therefore for peony and licorice decoction, select percutaneous dosing more to have superiority than for oral administration.
Long-term clinical practice proves that peony and licorice decoction all has therapeutical effect to multiple muscle spasm and local pain.Yet, though this side forms simply, adopt traditional extractum as raw material, effective ingredient is too complicated, difficult quality control, therapeutic mechanism is difficult to explanation.Middle pharmaceutically active ingredient is the material base of performance drug action, is prerequisite and the basis that Chinese medicine is further furtherd investigate and developed.Adopt effective ingredient or active component compatibility research Chinese medicine can guarantee that more the Chinese medicine clinical medicine dose is accurate, attenuation synergistic also deeply discloses its mechanism of action.
Big quantity research proves that the peony and licorice decoction main component is respectively peoniflorin and glycyrrhizic acid, and wherein after the glycyrrhizic acid oral administration, metabolism becomes enoxolone and plays a role in vivo.The peroral dosage form of Radix Paeoniae, Radix Glycyrrhizae extract comes out already, for the pharmacodynamic study of Radix Paeoniae effective liquorice and the different compatibilities of active component a lot of reports is arranged also, although conclusion difference to some extent, collaborative drug action is identified.Disclose a kind of peoniflorin and glycyrrhetinic acid composition among the patent CN101926815A, be used to process various peroral dosage forms, treatment rheumatoid arthritis and eczema; CN 200810135364.5 discloses peoniflorin percutaneous drug administration preparation and method for preparing.CN101433529A discloses a kind of glycyrrhizic acid transdermal formulation and preparation technology thereof, but does not provide any data that can explain that the glycyrrhizic acid transdermal penetration absorbs, just is used to treat dermatosis.Disclose the compositions that is used to promote glycyrrhetinic acid to realize percutaneous permeation among the patent CN101920017A, the percutaneous that adopts this technology can improve enoxolone absorbs.Can Chinese medicine classics side--shaogan soup through the percutaneous drug delivery performance drug action identical even more excellent with oral administration; Need be on the basis of establishing the effective ingredient transdermal penetration; Collaborative drug action to effective ingredient, active component compatibility proves, and prescription and technology is optimized.
Summary of the invention
The purpose of this invention is to provide and a kind ofly contain Radix Paeoniae and effective liquorice and can effectively suppress transdermal drug delivery system of monospasm and pain and preparation method thereof.
Technical problem to be solved by this invention is to improve Radix Paeoniae and effective liquorice transdermal penetration speed and the stability in pressure sensitive adhesive matrix; Through optimizing prescription and preparation technology; A kind of sweet patch of Chinese herbaceous peony with good spasmolytic and analgesic activities is provided, effectively prevents and treat diseases such as local organization spasm and pain.
Chinese herbaceous peony provided by the invention-Gan transdermal patch by being formed by lining, medicine carrying pressure-sensitive adhesive layer and adherent layer, is characterized in that: said medicine carrying pressure-sensitive adhesive layer adopts a kind of in the following prescription:
(1) forms by pressure sensitive adhesive, peoniflorin, enoxolone; The concrete composition as follows: contain 6%～30% weight ratio peoniflorin and 6%～30% weight ratio enoxolone in the medicine carrying pressure-sensitive adhesive layer; Contain 3%～10% weight ratio organic base simultaneously; 2%～15% weight ratio transdermal penetrating agent, 5%～15% weight ratio butanols and 40%～70% weight ratio pressure sensitive adhesive;
(2) form by pressure sensitive adhesive, the Radix Glycyrrhizae extract that contains the Radix Paeoniae Alba extract of peoniflorin and contain enoxolone; The concrete composition as follows: contain 6%～30% weight ratio Radix Paeoniae Alba extract and 6%～30% weight ratio Radix Glycyrrhizae extract in the medicine carrying pressure-sensitive adhesive layer; Contain 3%～10% weight ratio organic base simultaneously; 2%～15% weight ratio transdermal penetrating agent, 5%～15% weight ratio butanols and 40%～70% weight ratio pressure sensitive adhesive; Wherein contain 20%～90% weight ratio peoniflorin in the Radix Paeoniae Alba extract, contain 20%～90% weight ratio enoxolone in the Radix Glycyrrhizae extract.
Described organic base is diethylamine, diethanolamine, triethylamine, triethanolamine.
Described transdermal penetrating agent is selected from: contain the high fatty alcohol of 10～18 carbon atoms, the fatty acid ester that contains 3～16 carbon atoms, menthone, menthol, azone, Borneolum Syntheticum, Camphora or the combination of these materials more than two kinds, but combination the time does not comprise dimethyl sulfoxide; The high fatty alcohol that wherein contains 10～18 carbon atoms is meant decanol, myristyl alcohol, palmityl alcohol, stearyl alcohol etc.; The fatty acid ester that contains 3～16 carbon atoms is meant ethyl propionate, isopropyl myristate, isopropyl palmitate etc.
Said pressure sensitive adhesive is selected from acrylate pressure-sensitive adhesive, Polyisobutylene PSA, silicone rubber, natural rubber, styrene-isoprene-phenylethene hot-fusible pressure-sensitive adhesive (SIS type), s-B-S hot melt pressure sensitive adhesive (SBS type) and the blend more than two kinds thereof, is preferably the acrylate pressure-sensitive adhesive that does not contain functional groups (like
87-4098,
87-9301) or contain oh group (like
87-2510,
87-2287,
87-2516).For drug loading and the transdermal penetration speed of adjusting peoniflorin in the pressure sensitive adhesive, enoxolone can be mixed containing the oh group pressure sensitive adhesive or not containing the functional groups pressure sensitive adhesive.
In order to improve Chinese herbaceous peony-transdermal penetration of Gan patch effective ingredient (especially enoxolone) and the stability in substrate; In substrate, add cosolvent and promote effective ingredient or corresponding dissolubility and the percutaneous permeation of extract in substrate; Cosolvent is chosen as non-volatile butanols and organic base, adds total amount and is no more than 25% weight ratio.
In order further to improve effective ingredient transdermal penetration speed; Also in pressure sensitive adhesive, added the transdermal penetration promoter that skin is had certain compatibility; Consider pressure sensitive adhesive sticked Effect on Performance that the adding total amount of transdermal penetration promoter is no more than 15% weight ratio.
The thickness of the medicine carrying pressure-sensitive adhesive layer of Chinese herbaceous peony provided by the invention-Gan transdermal patch is 50 microns～500 microns, and area is 10～200cm2.
The sweet transdermal patch method for preparing of Chinese herbaceous peony provided by the invention is following:
It is subsequent use with the organic base stirring and dissolving that peoniflorin and enoxolone or their extract are added butanols, and medicinal liquid is added the back adding transdermal penetrating agent and continue to stir of stirring in the pressure sensitive adhesive.Glue is filmed on coating machine, and the thickness of medicine carrying pressure-sensitive adhesive layer is 50 microns～500 microns, covers backing layer after coating drying or the cooling, cutting and punch forming, and packed sealing is preserved.
The present invention is that index is screened the patch prescription with in-vitro percutaneous transit dose and the crystallization of substrate Chinese medicine; With the experiment of animal analgesic activities the paster prescription is optimized, prescription is optimized through transdermal penetration speed that improves medicine and the percutaneous analgesic activities that improves patch.
In-vitro percutaneous permeability test method provided by the invention is following:
The transdermal test in vitro absorption plant that adopts is the horizontal type diffusion cell, and effectively diffusion area is 0.627cm2, the skin that uses be QUMAO Corium Mus skin; In the experimentation paster is affixed on horny layer one side of skin; Then towards accepting the pond, the reception tank volume is 5.0ml to skin corium one side, sees through in the process to continue magnetic agitation; Mixing speed is 600～800rpm, and the temperature of using the peripheral circulation water-bath to keep reception tank is 37 ℃.
In vitro tests is the result show; Adopt hydrotropy systems such as organic base and butanols and the acrylate pressure-sensitive adhesive that does not contain carboxylic group to make up to make enoxolone accumulate infiltration capacity in 24 hours and improve nearly 40 times than common percutaneous patch permeability through Corium Mus; The transdermal penetration amount of enoxolone and peoniflorin all can reach about 1000 μ g/cm2 in 24 hours, adopted that the transdermal penetration amount of peoniflorin and enoxolone contains carboxylic group pressure sensitive adhesive system far above sweet transdermal delivery system of conventional Chinese herbaceous peony and employing in the sweet patch of Chinese herbaceous peony of this prescription.
The present invention provides acetic acid to cause mouse writhing and two analgesic test of dysmenorrhea, and its purpose is to explain the drug action of the sweet patch spasmolysis and analgesia of Chinese herbaceous peony, but and does not mean that the sweet transdermal patch of Chinese herbaceous peony only is applicable to that the pain of dysmenorrhea suppresses.
1, Chinese herbaceous peony-Gan patch Dichlorodiphenyl Acetate causes the analgesic activities of mouse writhing
Experiment mice is divided at random: negative control group; Blank matrix group; The meloxicam positive controls; Sweet patch A group of Chinese herbaceous peony (effective ingredient) and Chinese herbaceous peony glycosides patch B group (extract), 10 every group.
Before the experiment 24h, use depilatory to lose hair or feathers to mouse web portion.Blank matrix group is affixed on mouse web portion with blank paster (with administration group ratio, except that drug not, other composition is identical), with the fixing paster of adhesive tape, experimentizes behind the 12h; Every mouse stomach 0.5mg/mL of meloxicam positive controls meloxicam 0.2mL irritates stomach and experimentizes after 3 hours; The sweet patch group of Chinese herbaceous peony will contain medicine plaster and be affixed on mouse web portion, experimentize behind the 12h.After arriving the stipulated time; Mouse peritoneal is injected 0.6% acetic acid 0.2mL, observes the number of times (being that abdominal part indent, trunk and hind leg extension, behavior reactions such as hips up appear in mice) that writhing response appears in the interior mice of 20min; The body number of times turned round in record, and calculate the pain suppression ratio of medicine.Suppression ratio (%)={ (negative control group is on average turned round body number of times-administration group and on average turned round the body number of times)/matched group is on average turned round the body number of times } * 100%.Experimental result is seen table 1.
Experimental result shows, sweet patch A of Chinese herbaceous peony provided by the invention and B and positive drug meloxicam all make glacial acetic acid cause the mouse writhing number of times obviously to reduce, pain is had significant inhibitory effect.The analgesic activity that the sweet patch group of positive controls and Chinese herbaceous peony Dichlorodiphenyl Acetate causes mouse writhing is close; Peoniflorin-enoxolone or their extract in varing proportions compatibility (5: 1,3: 1,1: 1; 1: 3) Chinese herbaceous peony-Gan patch group (total content confirms as 36%) pain suppression ratio be respectively 74.7% and 83.4%; 62.8% and 70.3%, 53.3% and 55.6%, 43.5% and 45.2% (experimental result is seen table 1).Above-mentioned experimental result prompting Chinese herbaceous peony-Gan patch has good inhibitory effect to inflammatory pain, and the big more analgesic effect of peoniflorin ratio is good more in the paster.After transdermal patch sticked 12h, skin not show was swollen, showed that two kinds of patches of preparation in this experiment all do not have obvious irritation to skin.
2, Chinese herbaceous peony-Gan patch causes the analgesic activities of mouse writhing to dysmenorrhea
Experiment mice is divided at random: negative control group; Blank matrix group; The meloxicam positive controls; Chinese herbaceous peony-Gan patch A group and Chinese herbaceous peony-glycosides patch B group, 10 every group.Mice is irritated the stomach diethylstilbestrol 1 time every day, each 2mg/kg (volume is 5mL/kg), 12d continuously.Stomach meloxicam (0.5mg/mL, 0.2mL/ are only), successive administration 3 days are irritated in beginning in the 10th day, positive controls every day; Blank substrate and the sweet patch group of Chinese herbaceous peony stick 1 time successive administration 3 days every day.1h after the administration of diethylstilbestrol last, lumbar injection oxytocin 20U/kg, mice turns round body incubation period and turns round the body number of times in the record 30min.
Experimental result shows that sweet patch group of Chinese herbaceous peony and positive drug meloxicam cause mouse writhing to dysmenorrhea and have remarkable inhibitory action, and the mouse writhing number of times obviously reduces.Peoniflorin-enoxolone or their extract be compatibility (5: 1 in varing proportions; 3: 1; 1: 1,1: 3) Chinese herbaceous peony-Gan patch group (total content confirms as 36%) all have good dysmenorrhea mice pain suppression ratio, wherein 1: 1 group optimum; Analgesic effect even be superior to Xikang, U.S. Lip river positive drug matched group has very significant difference (P＜0.01) (experimental result is seen table 2) with negative control group.
Peoniflorin is the Chinese medicine ingredients with strong analgesic activities, and the peoniflorin proportion is high more, and analgesic effect is good more, and this also superincumbent acetic acid causes in the mouse writhing experiment and obtains checking.In the dysmenorrhea model test, we find, compare with using independent peoniflorin paster, and Chinese herbaceous peony-Gan patch group all has higher pain suppression ratio.Increase along with enoxolone content; The sweet patch group of Chinese herbaceous peony increases dysmenorrhea mice pain suppression ratio to some extent; When peoniflorin: the inhibitory action that when enoxolone reaches 1: 1 dysmenorrhea is caused mouse writhing reaches best, further increases the ratio of enoxolone, and action effect descends on the contrary; This research proof peoniflorin and enoxolone compatibility have the good curing effect to the dysmenorrhea that factor palace spasm causes, have shown the collaborative drug action of Radix Paeoniae and Radix Glycyrrhizae percutaneous dosing.The evidence of animal drug effect adopts the Chinese herbaceous peony-Gan transdermal patch of present technique preparation to can be used for alleviating and suppressing local organization spasm and pain symptom.
The sweet transdermal administration transdermal patch of a kind of Chinese herbaceous peony provided by the invention makes effective ingredient or the active component of two kinds of medical material Radix Paeoniaes and Radix Glycyrrhizae can the continuous and effective transdermal penetration, more effectively brings into play their collaborative drug actions at aspects such as topical pain relief, antiinflammatory, spasmolytic.
The accompanying drawing content
The external curve chart that sees through of peoniflorin in the sweet patch of Fig. 1 a difference in functionality group pressure sensitive adhesive Chinese herbaceous peony.
The external curve chart that sees through of enoxolone in the sweet patch of Fig. 1 b difference in functionality group pressure sensitive adhesive Chinese herbaceous peony.
Fig. 2 a different solvents influences comparison diagram to in-vitro percutaneous the seeing through of peoniflorin in Chinese herbaceous peony-Gan patch.
Fig. 2 b different solvents influences contrast effect to in-vitro percutaneous the seeing through of enoxolone in Chinese herbaceous peony-Gan patch.
The external curve chart that sees through of the different drug loading Chinese herbaceous peonies of Fig. 3 a-Gan patch (
87-4098) peoniflorin.
The external curve chart that sees through of the different drug loading Chinese herbaceous peonies of Fig. 3 b-Gan patch (
87-4098) enoxolone.
The specific embodiment
Specify below in conjunction with concrete embodiment, but it does not limit the present invention.Effective ingredient or effective component extracts and other constituent contents are all according to percentage by weight among the embodiment.
Embodiment 1
Peoniflorin 6, enoxolone 30, diethanolamine 10, azone 2, butanols 5
Hydroxyl group acrylate pressure-sensitive adhesive (
87-2287) 47
Embodiment 2
Peoniflorin 30, enoxolone 6, triethylamine 3, lauryl alcohol 10, butanols 5, silicone rubber pressure sensitive adhesive 46
Peoniflorin 18, enoxolone 18, triethanolamine 6, isopropyl myristate 10, butanols 8, natural rubber pressure sensitive adhesive 40
Embodiment 4
Peoniflorin 8, enoxolone 8, triethanolamine 3, stearyl alcohol 6, butanols 5,
The acrylate pressure-sensitive adhesive of hydroxyl functional group (
87-2516) 70
Peoniflorin 27, enoxolone 9, diethylamine 3, decanol 15, butanols 5,
SIS/SBS blend hot-fusible pressure-sensitive adhesive 41
Peoniflorin 12, enoxolone 24, triethanolamine 7, azone 2, butanols 15,
Do not contain functional group propenoic acid ester pressure sensitive adhesive (
87-4098) 40
Embodiment 7
Extract product of paeoniflorin 15, enoxolone extract 15, triethylamine 5, Borneolum Syntheticum 10, butanols 15,
SIS type hot-fusible pressure-sensitive adhesive 40
Embodiment 8
Extract product of paeoniflorin 6, enoxolone extract 30, triethanolamine 10, azone 2,
Embodiment 9
Extract product of paeoniflorin 30, enoxolone extract 6, triethanolamine 3, ethyl propionate 7, menthol 3, butanols 10, Polyisobutylene PSA 41
Embodiment 10
Extract product of paeoniflorin 24, enoxolone extract 12, triethylamine 4, isopropyl myristate 10,
Butanols 10, do not contain functional group propenoic acid ester pressure sensitive adhesive (
87-4098) 40
Embodiment 11
Extract product of paeoniflorin 10, enoxolone extract 10, diethylamine 3, isopropyl palmitate 15,
Extract product of paeoniflorin 8, enoxolone extract 12, diethanolamine 3, menthone 2, butanols 5, Polyisobutylene PSA 70
Embodiment 13
Subsequent use with being stirred to dissolving among peoniflorin 10g and enoxolone 15g adding butanols 10g and the triethanolamine 5g, medicinal liquid is added the back that stirs among acrylate pressure-sensitive adhesive (
87-4098) 143g (solid content 38.5%) add azone 5g and continue stirring and dissolving.120 μ m is thick films on coating machine with glue, covers backing layer after 70～90 ℃ of program dryings of coating, cutting and punch forming, and preparation thickness is Chinese herbaceous peony-Gan patch of 50 μ m, packed sealing room temperature is preserved.
Embodiment 14
Subsequent use with being stirred to dissolving among extract product of paeoniflorin 10g and enoxolone extract 10g adding butanols 5g and the triethylamine 5g; The 7g Borneolum Syntheticum is joined airtight stirring in the fused SIS type of the 63g hot-fusible pressure-sensitive adhesive under 120 ℃ of conditions, under 90 ℃ of conditions, add above-mentioned subsequent use medicinal liquid and continue to stir.Glue is filmed on coating machine, cover backing layer after the coating cooling, cutting and punch forming, preparation thickness is Chinese herbaceous peony-Gan patch of 500 μ m, packed sealing room temperature is preserved.
Shown in Fig. 1 a, Fig. 1 b, Fig. 2 a, Fig. 2 b, Fig. 3 a, Fig. 3 b.
Table 1 Chinese herbaceous peony-Gan patch Dichlorodiphenyl Acetate causes the analgesic activities of mouse writhing
Annotate: A: peoniflorin (PF)-enoxolone (GA) group;
B: extract product of paeoniflorin (PE) (peoniflorin 70%wt)-enoxolone extract (GE) (enoxolone 70%wt) z group;
Compare * P＜0.05, * * P＜0.01 with negative control group.
Table 2 Chinese herbaceous peony-Gan patch causes the analgesic activities of mouse writhing to dysmenorrhea
Annotate: A: peoniflorin (PF)-enoxolone (GA) group;
B: extract product of paeoniflorin (PE) (peoniflorin 70%wt)-enoxolone extract (GE) (enoxolone 70%wt) z group;
Compare * P＜0.05, * * P＜0.01 with negative control group.
Claims (5)
1. transdermal patch that contains peoniflorin and enoxolone by being formed by lining, medicine carrying pressure-sensitive adhesive layer and adherent layer, is characterized in that: said medicine carrying pressure-sensitive adhesive layer adopts a kind of in the following prescription:
(1) forms by pressure sensitive adhesive, peoniflorin, enoxolone; The concrete composition as follows: contain 6%～30% weight ratio peoniflorin and 6%～30% weight ratio enoxolone in the medicine carrying pressure-sensitive adhesive layer; Contain 3%～10% weight ratio organic base simultaneously; 2%～15% weight ratio transdermal penetrating agent, 5%～15% weight ratio butanols and 40%～70% weight ratio pressure sensitive adhesive;
(2) form by pressure sensitive adhesive, the Radix Glycyrrhizae extract that contains the Radix Paeoniae Alba extract of peoniflorin and contain enoxolone; The concrete composition as follows: contain 6%～30% weight ratio Radix Paeoniae Alba extract and 6%～30% weight ratio Radix Glycyrrhizae extract in the medicine carrying pressure-sensitive adhesive layer; Contain 3%～10% weight ratio organic base simultaneously; 2%～15% weight ratio transdermal penetrating agent, 5%～15% weight ratio butanols and 40%～70% weight ratio pressure sensitive adhesive; Wherein contain 20%～90% weight ratio peoniflorin in the Radix Paeoniae Alba extract, contain 20%～90% weight ratio enoxolone in the Radix Glycyrrhizae extract;
Described organic base is diethylamine, diethanolamine, triethylamine, triethanolamine;
Described transdermal penetrating agent is selected from: contain the high fatty alcohol of 10～18 carbon atoms, the fatty acid ester that contains 3～16 carbon atoms, menthone, menthol, azone, Borneolum Syntheticum, Camphora or the combination of these materials more than two kinds, but do not comprise dimethyl sulfoxide and higher fatty acids;
Pressure sensitive adhesive is selected from acrylate pressure-sensitive adhesive, Polyisobutylene PSA, silicone rubber, natural rubber, SIS type styrene-isoprene-phenylethene hot-fusible pressure-sensitive adhesive, SBS type s-B-S hot melt pressure sensitive adhesive and the blend more than two kinds thereof.
2. a kind of transdermal patch that contains peoniflorin and enoxolone according to claim 1 is characterized in that the high fatty alcohol that contains 10～18 carbon atoms is meant decanol, myristyl alcohol, palmityl alcohol, stearyl alcohol; The fatty acid ester that contains 3～16 carbon atoms is meant ethyl propionate, isopropyl myristate, isopropyl palmitate.
3. a kind of transdermal patch that contains peoniflorin and enoxolone according to claim 1 is characterized in that acrylate pressure-sensitive adhesive is meant the acrylate pressure-sensitive adhesive that does not contain carboxylic group.
4. the method for preparing of claim 1,2 or 3 said transdermal patches; It is characterized in that; It is subsequent use with the organic base stirring and dissolving that peoniflorin and enoxolone or their extract are added butanols, and medicinal liquid is added the back adding transdermal penetrating agent and continue to stir of stirring in the pressure sensitive adhesive; Glue is filmed on coating machine, and the thickness of medicine carrying pressure-sensitive adhesive layer is 50 microns～500 microns, covers backing layer after coating drying or the cooling, cutting and punch forming, and packed sealing is preserved.
5. the application of claim 1,2 or 3 said transdermal patches is characterized in that this transdermal patch is used to prepare the medicine of alleviating and suppressing local organization spasm and pain.
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| CN102362964B (en) * | 2011-10-21 | 2018-06-01 | 无锡济民可信山禾药业股份有限公司 | A kind of new preparation for treating acute injury of soft tissue and preparation method thereof |
| CN102940754B (en) * | 2012-12-11 | 2014-04-09 | 南京中医药大学 | Rhizoma cyperi four-drug decoction transdermal patch and preparation method thereof |
| CN106433525A (en) * | 2016-09-28 | 2017-02-22 | 四川三和医用材料有限公司 | Medical pressure-sensitive adhesive |
| CN106512069A (en) * | 2016-09-28 | 2017-03-22 | 四川三和医用材料有限公司 | Medical pressure-sensitive adhesive anti-inflammatory and bactericidal additive |
| CN106361821A (en) * | 2016-09-28 | 2017-02-01 | 四川三和医用材料有限公司 | Inflammation resisting, sterilizing, wind dispelling and dampness eliminating plaster |
| CN106543934A (en) * | 2016-09-28 | 2017-03-29 | 四川三和医用材料有限公司 | A kind of medical antiinflammatory sterilization pressure-sensitive adhesive |
| CN111000888A (en) * | 2019-12-27 | 2020-04-14 | 浙江中医药大学 | Tripterygium wilfordii residue patch and preparation method thereof |
| CN115245529A (en) * | 2021-04-26 | 2022-10-28 | 上海幼官健康管理有限公司 | Skin penetrating agent and external pain relieving medicine prepared from same |
| CN114306211B (en) * | 2021-12-29 | 2023-12-22 | 中国药科大学 | Glycyrrhizic acid supermolecule self-assembled temperature-sensitive interpenetrating network gel and preparation method and application thereof |
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