CN100387154C - Health-care food for relieving-vision fatigue and its prepn. method - Google Patents
Health-care food for relieving-vision fatigue and its prepn. method Download PDFInfo
- Publication number
- CN100387154C CN100387154C CNB2005100956285A CN200510095628A CN100387154C CN 100387154 C CN100387154 C CN 100387154C CN B2005100956285 A CNB2005100956285 A CN B2005100956285A CN 200510095628 A CN200510095628 A CN 200510095628A CN 100387154 C CN100387154 C CN 100387154C
- Authority
- CN
- China
- Prior art keywords
- health food
- rosa roxburghii
- test
- freeze
- health
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title description 13
- 235000013305 food Nutrition 0.000 title description 6
- 239000000843 powder Substances 0.000 claims abstract description 21
- 244000241838 Lycium barbarum Species 0.000 claims abstract description 20
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 20
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 15
- 238000002360 preparation method Methods 0.000 claims abstract description 14
- 208000003464 asthenopia Diseases 0.000 claims abstract description 12
- 238000005516 engineering process Methods 0.000 claims abstract description 9
- 235000000640 Rosa roxburghii Nutrition 0.000 claims description 25
- 240000002547 Rosa roxburghii Species 0.000 claims description 25
- 235000013399 edible fruits Nutrition 0.000 claims description 25
- 244000078534 Vaccinium myrtillus Species 0.000 claims description 24
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims description 24
- 235000013402 health food Nutrition 0.000 claims description 21
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 14
- 229930014669 anthocyanidin Natural products 0.000 claims description 10
- 150000001452 anthocyanidin derivatives Chemical class 0.000 claims description 10
- 235000008758 anthocyanidins Nutrition 0.000 claims description 10
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 7
- 229930003268 Vitamin C Natural products 0.000 claims description 7
- 239000002775 capsule Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 235000019154 vitamin C Nutrition 0.000 claims description 7
- 239000011718 vitamin C Substances 0.000 claims description 7
- 238000009472 formulation Methods 0.000 claims description 6
- 230000000813 microbial effect Effects 0.000 claims description 6
- 239000007910 chewable tablet Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 229940068682 chewable tablet Drugs 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 239000012467 final product Substances 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 229940102480 bilberry extract Drugs 0.000 abstract 1
- 235000019209 bilberry extract Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 21
- 235000016357 Mirtillo rosso Nutrition 0.000 description 19
- 244000077923 Vaccinium vitis idaea Species 0.000 description 19
- 235000017606 Vaccinium vitis idaea Nutrition 0.000 description 19
- 230000004310 photopic vision Effects 0.000 description 13
- 239000008280 blood Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 11
- 230000004438 eyesight Effects 0.000 description 11
- 208000024891 symptom Diseases 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- 230000006870 function Effects 0.000 description 9
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 238000007689 inspection Methods 0.000 description 8
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 7
- 235000021014 blueberries Nutrition 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 102000004330 Rhodopsin Human genes 0.000 description 4
- 108090000820 Rhodopsin Proteins 0.000 description 4
- 206010047513 Vision blurred Diseases 0.000 description 4
- 229930002877 anthocyanin Natural products 0.000 description 4
- 235000010208 anthocyanin Nutrition 0.000 description 4
- 239000004410 anthocyanin Substances 0.000 description 4
- 150000004636 anthocyanins Chemical class 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 206010034960 Photophobia Diseases 0.000 description 3
- 206010039966 Senile dementia Diseases 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 208000002173 dizziness Diseases 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000007908 dry granulation Methods 0.000 description 3
- 230000002526 effect on cardiovascular system Effects 0.000 description 3
- 206010016256 fatigue Diseases 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000201295 Euphrasia Species 0.000 description 2
- 208000010412 Glaucoma Diseases 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 241000736767 Vaccinium Species 0.000 description 2
- 240000001717 Vaccinium macrocarpon Species 0.000 description 2
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 description 2
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 description 2
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 2
- 238000011047 acute toxicity test Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical group C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 235000004634 cranberry Nutrition 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 208000001491 myopia Diseases 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- NCYCYZXNIZJOKI-IOUUIBBYSA-N 11-cis-retinal Chemical compound O=C/C=C(\C)/C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-IOUUIBBYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 108700016947 Bos taurus structural-GP Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- RDFLLVCQYHQOBU-GPGGJFNDSA-O Cyanin Natural products O([C@H]1[C@H](O)[C@H](O)[C@H](O)[C@H](CO)O1)c1c(-c2cc(O)c(O)cc2)[o+]c2c(c(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O3)cc(O)c2)c1 RDFLLVCQYHQOBU-GPGGJFNDSA-O 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229940123457 Free radical scavenger Drugs 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 244000241872 Lycium chinense Species 0.000 description 1
- 235000015468 Lycium chinense Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 244000170916 Paeonia officinalis Species 0.000 description 1
- 235000006484 Paeonia officinalis Nutrition 0.000 description 1
- 102000016387 Pancreatic elastase Human genes 0.000 description 1
- 108010067372 Pancreatic elastase Proteins 0.000 description 1
- 241000781608 Scolopia zeyheri Species 0.000 description 1
- 235000012511 Vaccinium Nutrition 0.000 description 1
- 240000001417 Vigna umbellata Species 0.000 description 1
- 235000011453 Vigna umbellata Nutrition 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 210000003792 cranial nerve Anatomy 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- RDFLLVCQYHQOBU-ZOTFFYTFSA-O cyanin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=[O+]C1=CC(O)=C2)C=3C=C(O)C(O)=CC=3)=CC1=C2O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 RDFLLVCQYHQOBU-ZOTFFYTFSA-O 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000000254 damaging effect Effects 0.000 description 1
- 230000004300 dark adaptation Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000009982 effect on human Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 208000027993 eye symptom Diseases 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000005078 fruit development Effects 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229940094952 green tea extract Drugs 0.000 description 1
- 235000020688 green tea extract Nutrition 0.000 description 1
- 235000001497 healthy food Nutrition 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000002189 macula lutea Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 238000005065 mining Methods 0.000 description 1
- 230000004297 night vision Effects 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 235000015206 pear juice Nutrition 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 238000010010 raising Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009711 regulatory function Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 239000008925 shengjing Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 208000000143 urethritis Diseases 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a health-care product for relieving asthenopic and a preparation technology thereof. The health-care product is prepared from bilberry extract, matrimony vine and fructus rosae normalis juice frozen dry powder. The health-care product can effectively relieve asthenopia, and has the advantages of good safety and simple and easy preparation technology.
Description
Technical field
The invention belongs to field of health care food, relate to a kind of health food that can alleviating asthenopia, the invention still further relates to the preparation technology of this health food.
Background technology
Cowberry, Ericaceae Vaccinium, perennial fallen leaves or evergreen fruit trees, shrub.Formal name used at school Vaccinium spp..Cranberry is divided into red, blue, Bai Sanse, American-European countries is called blueberry with blue fruit, also claims blue berry, and the English of cowberry claims " Bilberry " in Europe, claim in the U.S. " Blueberry ".Blueberry is the extremely strong wild plant of a kind of cold resistance, can resist subzero-50 ℃ severe cold, originate in ground such as North America, Northern Europe and Russia, it is a kind of wild acinus that is grown in height above sea level 1500-2500 meter, it is the wild resource of spontaneous growth in the forest, mankind's several centuries of searching for food is subjected to American-European consumer's favor deeply because of the effect uniqueness.Blueberry is the abundantest kind of nutritional labeling in the cowberry, and the content of natural colouring matter, ferroheme is also the highest, and the content of anthocyanin, SOD surpasses other plant manyfold.U.S. scientist finds to contain in the cowberry anthocyanin, flavonoids, unknown enzyme and anti-cancer active matter, take for a long time the eyesight that can keep the people lasting, strengthen cardiovascular and cerebrovascular and arteries, having rejuvenescent magical effect, is the cri dernier cri fashion of states such as America and Europe.Cowberry also has the effect of improvement to women's urethral infection, the how small-sized clinical studies of Finland and other Guo Jia Xu has confirmed that it can reduce the symptom of women's urinary tract infection.Studies confirm that cowberry can quicken the ability that visual purple is lived again, visual purple is that night vision is necessary, therefore eats cowberry and is of great benefit to improving eyesight.Remove this, cowberry also can be improved yctalopia or dark adaptation disease, and improves the recovery capability of eye fatigue.Now, Bilberry fruit P.E is widely used in a series of eyesights and the cardiovascular health-care function product, fails and hemorrhoid as retina symptom, cataract, glaucoma, macula lutea due to the diabetes.The most influential health magazine of the U.S. " Prevention " claims that cowberry really is " a magical fruit ".Contain abundant nourishing healthy composition in the cranberry, make cowberry in countries in the world all as nourishing healthy fruit Development and Production.
Contain anthocyanidin in the cowberry and (have another name called anthocyanidin Cyanin, anthocyanin, anthocyanin), experimental results show that the most potent free radical scavenger that anthocyanidin is up to now to be found, its Green Tea Extract oxidability is ascorbic 20 times, be 50 times of vitamin E, its activity in vivo especially, other antioxidants are incomparable especially.The contained cyanine rope of cowberry is that content is the highest in all fruit and vegetables, and the abundantest part of anthocyanidin of cowberry is exactly at its distinctive purple pericarp position.Anthocyanidin all has remarkable efficacy to vascular sclerosis, heart disease, delaying senility, enhancing memory, especially can increase glue protein, can reduce intraocular pressure, and easing eyes fatigue is of value to glaucoma and cataract.Cowberry anthocyanidin belongs to little molecule, water-soluble substances, and peroral dosage form easily by the human body fast Absorption, can enter each histoorgan of human body fast after oral 45 minutes.Anthocyanidin has bioavilability preferably in human body, strong to connective tissue affinity, and stable under sour environment, long half time can reach 27 hours, and effect is lasting.According to the U.S., Japan, the scholar of European Section research, often edible cowberry goods can strengthen eyesight, anti-eye strain significantly; Skin nutrition; Delay the cranial nerve aging; The capillary that is caused by diabetes there is therapeutic action; Strengthen heart function; The prevention senile dementia.Just because of nutrition and the medicinal function of cowberry, make international food and agricultural organization classify them one of as human five big healthy food.At home, the health care of this fruit is worth and also is familiar with by the consumer gradually.
Cowberry has another name called Wen Pu (" Shengjing city leads to will "), red bean, tooth pimple.Meridian distribution of property and flavor: bitter, cold stomach, large intestine two warps.Effect: clearing heat and expelling damp.Cure mainly: control dysentery, enteritis.
Matrimony vine, it is sweet to distinguish the flavor of, and property is flat.Nourishing liver and kidney, benefiting shrewd head.Be used for dizzy, dizzy, tinnitus, hypopsia, cough due to consumptive disease, ache of the spinal column, seminal emission, diabetes etc.Compendium of Material Medica record matrimony vine function is: nourishing liver and kidney, benefiting shrewd head.Cure mainly: consumptive disease is smart to be lost, soreness of waist and knee joint, and dizzy tinnitus, interior heat is quenched one's thirst, and the deficiency of blood is sallow, and blurred vision is not clear." book on Chinese herbal medicine converges and says " record: " matrimony vine can make gas fill, and blood can be mended, Yang Kesheng, and the moon can be grown, rheumatism is dispelled, and perfect magical effect is arranged ".
Modern pharmacology has been done more deep research to Chinese wolfberry fruit: 1, improve the immunity of organism regulatory function.2, anti-sudden change, deferring senility.3, antitumor, reduce blood fat, reduce the cholesterol function.4, antifatigue, function makes eye bright.5, protection liver function.Mouse is carried out bone marrow micronucleus test, mouse sperm deformity test, acute toxicity test and 30 days feeding trials of rat.Conclusion: the acute toxicity test in mice maximal tolerance dose is greater than 36.0g/kg; 30 days feeding trials of rat do not see that the ANOMALOUS VARIATIONS of behavior, body weight, blood picture, liver, renal function appears in animal, and histotomy is not seen between each group yet, the internal organs structure has notable difference between two kinds of sexes; Bone marrow cells in mice is not seen damaging action; Mouse sperm is not produced the distortion effect.Therefore, take matrimony vine safety for a long time.
Rosa roxburghii is wild undershrub, opens pink, red or peony flower four to June, and the summer flower autumn is real.Fruit mostly is oblate sphere, and pulp is crisp, and the little corn of close life on the pericarp is commonly called as and is " Rosa roxburghii ".Fruit contains abundant vitamin C, and every hectogram fruit drink can contain Catergen 000mg, is described as " king of vitamin C " in the fruit, is job that requires special skills personnel such as aviation, navigation, plateau and mining and old and weak people, women and children's important nutraceutical.
But the health food that still cowberry, matrimony vine, Rosa roxburghii prescription is not used for alleviating asthenopia at present.
List of references:
1, State Administration of Traditional Chinese Medicine, " China's book on Chinese herbal medicine ", Shanghai science tech publishing house.
2, Li Hongbing, Shi Bin etc., lycium barbarum king capsule safety evaluatio, Ningxia Medicine College's journal, 2003,25 (5).
3, Chen Wei, blueberry and alimentary health-care function thereof, China and foreign countries' food industry, 2003.
4, Sun Guibao, the health-care effect of blueberry and various countries' cultivation development trend, agricultural research, 2002.
5, Yuan Weixian, Rosa roxburghii exploitation and cultivation technique thereof, Guangxi tropical agriculture, 2004.
6, Fang Xiuxian, the nutritive value of Rosa roxburghii and development and use thereof, food industry science and technology, 2004.
Summary of the invention
The purpose of this invention is to provide a kind of health food that can alleviating asthenopia.
Another object of the present invention provides the preparation technology of above-mentioned health food.
The prescription basis of technical solution of the present invention: Bilberry fruit P.E can quicken the effect of the regeneration rate of rhodopsin, with the vitamin combination, the amphiblestroid CSF of both collaborative raisings, suppress clostridiopetidase A, pancreatopeptidase E destruction to wall of micrangium matrix, suppress the biosynthesis of poly collagen and structural glycoprotein, strengthen the tension force of vascular wall, the basement membrane thickened phenomenon is recovered.Cowberry can be accelerated the visual purple regeneration rate in this prescription, improves ocular blood circulation and asthenopic effect, and matrimony vine has the effect that easypro liver makes eye bright, and the Rosa roxburghii juice freeze-dried powder is rich in vitamin C, has antioxidation, and we have the effect of alleviating asthenopia.
The objective of the invention is to realize by following technical measures:
A kind of health food of alleviating asthenopia, its prescription contains the raw material of following weight portion:
Bilberry fruit P.E 60-90 part, matrimony vine 300-450 part, Rosa roxburghii juice freeze-dried powder 320+400 part.
Described health food, wherein Bilberry fruit P.E is directly bought from market and is obtained, and the quality standard of Bilberry fruit P.E is: anthocyanidin 〉=1000mg/100g, moisture≤5.0wt%, ash content≤1.0wt%, microbial count≤1000cfu/g.The outward appearance of Bilberry fruit P.E is pink toner art.
Described health food, wherein the Rosa roxburghii juice freeze-dried powder prepares by following method: fresh Rosa roxburghii is after squeezing the juice, and freeze drying is pulverized and to be got final product; The quality requirement of Rosa roxburghii freeze-dried powder is: vitamin C 〉=25%, moisture≤4.0%, ash content≤1.0%, microbial count≤1000cfu/g.The outward appearance of Rosa roxburghii freeze-dried powder is a light brown powder, and the peculiar fragrance of Rosa roxburghii is arranged.
Described health food, its preparation are any one formulations that pharmaceutically allows, and include but not limited to chewable tablet, capsule, oral liquid, granule etc., can add the auxiliary material that pharmaceutically allows and adopt this formulation common process to be prepared from.Can also add other materials that do not weaken health food asthenopia releasing function of the present invention in the health food of the present invention and make the health food of complex function.
The preparation technology of described health food comprises the following step:
200 mesh sieves were pulverized in matrimony vine 50-70 ℃ oven dry, added Bilberry fruit P.E, Rosa roxburghii juice freeze-dried powder then in proportion, mixed, and adopted non high temperature (being no more than 60 ℃) preparation process to make required formulation.
In the preparation process since in this invention active ingredient contain heat-sensitive substances such as vitamin C, meet thermal conductance and cause that functional component is active to be destroyed, therefore, should adopt the preparation process of non high temperature, as needing dry granulation when film-making agent, the capsule.
Beneficial effect of the present invention:
One, health food of the present invention improves the clinical observation data (carrying out clinical observation by Beijing Disease Prevention and Control Centre and Xiyuan Hospital, Chinese Medicine Academy of China) of eyesight effect on human body test-meal experiment
(1) object and method
1, tried thing: chewable tablet of the present invention (pressing embodiment 1 preparation), the 1.5g/ sheet, Nanjing Zhongke Biochemical Technology Co., Ltd provides, lot number 20031215.
2, study subject: selecting the age by the principle of voluntariness is 18-65 year, eyesight fatiguability person.
3, the experimenter includes standard in: long-term with eye, eyesight fatiguability person.
4, experimenter's exclusion standard:
4.1, suffer from infectivity, traumatic eye part disease person;
4.2, suffer from inside and outside eye disease patient such as cornea, crystal, vitreum, eyeground pathological changes;
4.3, suffer from disease patients such as cardiovascular, the cerebrovascular, liver, kidney, hemopoietic system;
4.4, take the article relevant in a short time with being tried function, influence judgement person as a result;
4.5, take the medicine of relevant treatment eyesight for a long time, health products or use the other treatment method to fail termination person;
4.6, do not meet the standard of including in, the edible in accordance with regulations person that tried the thing, or data is not congruent influences effect or security judgement person.
5, test method:
5.1, experimental design and grouping: 100 routine experimenters are divided into test-meal group and blank group at random, every group of each 50 people, contrast between self cross-reference and group is adopted in test.
5.2, test method: the test-meal group is taken and is tried thing, and 4 of every days, control group is a blank, and duration of trial is 30 days.
6, instrument and equipment:
6.1, MEK-6318K type blood counting instrument (Japan produce), urinate ten analyzers (German Bao Ling Man product), RA1000 automatic clinical chemistry analyzer (U.S.'s product), biochemical reagents box (middle living company).Ophthalmoscope, slit-lamp, international standard visual chart.
6.2, be used for " product " font solid calcspar that duration of photopic vision is measured.
7, observation index:
Each measures once every index when test-meal on-test and end.
7.1 normal observation project: subjective sensation, sleep state, mental status etc.;
7.2 security inspection: general physical examination, blood, urine, just routine and blood biochemistry index inspection, other corresponding inspections;
7.3 eye symptom inspection:
7.3.1, detailed medical history-taking, observe the eye subjective symptoms: eye expands, ophthalmodynia, photophobia, blurred vision, eye are dry and astringent etc.Before and after test-meal, add up integrated value by symptom weight (severe 3 minutes, moderate 2 minutes, light disease 1 minute), and improve (each doing well,improving 1 is divided into effectively, improves 2 and is divided into produce effects), calculate the doing well,improving rate with regard to its cardinal symptom.
7.3.2, the ophthalmology routine inspection: external eyes, interior eye and eyeground.
7.4 duration of photopic vision is measured: the percentage of photopic vision time to fixation time is called duration of photopic vision, and minute is 3 minutes, measures twice and averages.
7.5 eye test:
7.5.1, examination of distant vision: use the inspection of GB visual chart.
7.5.2, examination of near vision: use the inspection of GB near vision test type.
8, data are handled:
With the STATE6.0 of statistical software computational analysis data.All own control data adopt paired t-test, two groups of means relatively adopt t check in groups, and the latter need carry out homogeneity test of variance, and the data of Non-Gaussian Distribution or heterogeneity of variance are carried out suitable variable conversion, after waiting to satisfy the normal state homogeneity of variance, carry out the t check with data converted; If translation data still can not satisfy the requirement of normal state homogeneity of variance, use t ' check or rank test instead; But the coefficient of variation too data of big (as CV＞50%) is used rank test.Effect index X
2Check.
9, the result judges:
9.1, doing well,improving: symptoms such as after off-test, ophthalmodynia, eye expand, photophobia, blurred vision, eye are dry and astringent take a turn for the better or disappear;
9.2, effectively: duration of photopic vision improves more than or equal to 0.1, test-meal group and control group relatively, learning processing difference by statistics has conspicuousness, can think to have the asthenopic health-care effect of improvement;
9.3, invalid: do not reach effective standard.
(2) observed result:
1, physical data: observe 100 routine asthenopes altogether, be divided into test-meal group, each 50 example of control group at random.The test-meal group male sex 15 examples, women's 35 examples; Age 21-65 year, 49.02 years old mean age; The photopic vision time is the shortest 87 seconds, and is the longest 138 seconds, average course of disease 3.61 years.The control group male sex 17 examples, women's 33 examples, age 22-64 year, average 47.88 years old; The photopic vision time is the shortest 86 seconds, and is the longest 128 seconds, average course of disease 3.71 years.
2, two groups observe last as situation relatively (seeing Table 1):
Situation comparison as table 1 observation is last (X ± SD)
Every index no significant difference (P＞0.05) before two groups of test-meals has comparativity.
3, improve eyesight effect (seeing Table 2):
The comparison that distant vision changes before and after the table 2 liang group test-meal (X ± SD)
Test-meal group own control before and after the test-meal:
*P＜0.01; Contrast between group: #P＜0.05
4, duration of photopic vision changes relatively (seeing Table 3)
The comparison that duration of photopic vision changes before and after the table 3 liang group test-meal (X ± SD), unit: %
| Grouping | Before the test-meal (n=50) | After the test-meal (n=50) | Improve percentage |
| The test-meal group | 59.52±7.31 | 72.22±10.71*** | 21.34# |
| Control group | 58.81±6.99 | 58.76±6.66 | -0.08 |
Test-meal group own control before and after the test-meal:
* *P＜0.001; Contrast between group after the test-meal: #P＜0.05
5, doing well,improving situation (seeing Table 4):
Table 4 cardinal symptom is improved situation
Aspect each cardinal symptom improved, each group of test-meal group all was better than control group.
6, the duration of photopic vision effect compares (seeing Table 5)
The duration of photopic vision effect relatively before and after table 5 test-meal
| Grouping | The example number | Effectively | Invalid | Total effective rate (%) |
| The test-meal group | 50 | 32(64.00％) | 18(36.00％) | 64.00％# |
| Control group | 50 | 4(8.00％) | 46(92.00％) | 8.00％ |
Test-meal group and control group are relatively before and after the test-meal: #P＜0.05
7, symptom integration statistics (seeing Table 6):
Table 6 clinical symptoms integration statistics (X ± SD)
| Grouping | The example number | Before the test-meal | After the test-meal | Difference |
| The test-meal group | 50 | 5.20±2.23 | 3.60±2.19 | -1.60±1.18*** |
| Control group | 50 | 5.00±2.47 | 4.40±2.39 | -0.60±0.78***# |
Test-meal group own control before and after the test-meal:
* *P＜0.001; Contrast between group: #P＜0.05
8, safety indexes is observed (seeing Table 7):
Security inspection result comparison before and after table 7 test-meal (X ± SD)
Before and after the test-meal, two groups of crowds' blood, urine, just routine and blood biochemistry index check result be substantially in normal range (NR).
In the test-meal process, do not observe allergy and other bad reactions.
(3) conclusion:
1, medicine of the present invention has the health care of alleviating asthenopia, test-meal group eyes duration of photopic vision on average improves 21.34%, and total effective rate is 64.00%, and the control group duration of photopic vision on average improves-0.08%, total effective rate is 8.00%, and learning processing difference by statistics has conspicuousness.
2, compare with control group, the present invention is dry and astringent for examination trencherman's blurred vision, eye, symptoms such as eye expands, ophthalmodynia, photophobia have the improvement effect.
3, test-meal group and control group blood before and after the test-meal, urine, just routine and blood biochemistry index are all no abnormal, obviously influence trying the healthy nothing of trencherman, and be safe.
The specific embodiment
The invention will be further elaborated by the following examples.
Embodiment adopts raw material sources and quality standard explanation:
Bilberry fruit P.E is directly to buy from market to obtain, and the quality standard of Bilberry fruit P.E is: anthocyanidin 〉=1000mg/100g, and moisture≤5.0wt%, ash content≤1.0wt%, microbial count≤1000cfu/g, outward appearance is a pink powder.
The Rosa roxburghii juice freeze-dried powder prepares by following method: fresh Rosa roxburghii is pressed the freeze drying of freeze-dried powder common process after squeezing the juice, and pulverizes to get final product; The quality requirement of Rosa roxburghii freeze-dried powder is: vitamin C 〉=25wt%, and moisture≤4.0wt%, ash content≤1.0wt%, microbial count≤1000cfu/g, outward appearance is a light brown powder, and the peculiar fragrance of Rosa roxburghii is arranged.
Embodiment 1
Get Bilberry fruit P.E 75g, matrimony vine 382.5g, Rosa roxburghii juice freeze-dried powder 360g, L-HPC 450g, pregelatinized starch 225g, dolomol 7.5g, 60 ℃ of oven dry of matrimony vine, pulverized 200 mesh sieves, supplementary material was mixed, made 1000 chewable tablets by chewable tablet dry granulation common process (being no more than 60 ℃).
Embodiment 2
Get Bilberry fruit P.E 60g, matrimony vine 400g, the thorn pear juice freezes in powder 380g, and 200 mesh sieves were pulverized in 50 ℃ of oven dry of matrimony vine, added the conventional auxiliary material of oral liquid, and supplementary material is mixed, and made the 1000ml oral liquid by oral liquid common process (being no more than 60 ℃).
Embodiment 3
Get Bilberry fruit P.E 90g, matrimony vine 300g, Rosa roxburghii juice freeze-dried powder 400g, 200 mesh sieves were pulverized in 60 ℃ of oven dry of matrimony vine, added the conventional auxiliary material of capsule, and supplementary material is mixed, and made 1000 capsules by capsule dry granulation common process (being no more than 60 ℃).
Embodiment 4
Get Bilberry fruit P.E 80g, matrimony vine 450g, Rosa roxburghii juice freeze-dried powder 320g, 200 mesh sieves were pulverized in 70 ℃ of oven dry of matrimony vine, added the conventional auxiliary material of granule, and supplementary material is mixed, and made 1000 bag particles by granule common process (being no more than 60 ℃).
Claims (6)
1. the health food of an alleviating asthenopia, contain the raw material of following weight portion in it is characterized in that filling a prescription:
Bilberry fruit P.E 60-90 part, matrimony vine 300-450 part, Rosa roxburghii juice freeze-dried powder 320-400 part.
2. health food according to claim 1 is characterized in that Bilberry fruit P.E directly obtains from the market purchase, and its quality standard is: anthocyanidin 〉=1000mg/100g, moisture≤5.0wt%, ash content≤1.0wt%, microbial count≤1000cfu/g.
3. health food according to claim 1 is characterized in that the Rosa roxburghii juice freeze-dried powder prepares through the following steps: fresh Rosa roxburghii is after squeezing the juice, and freeze drying is pulverized and to be got final product; The quality requirement of Rosa roxburghii freeze-dried powder is: vitamin C 〉=25%, moisture≤4.0%, ash content≤1.0%, microbial count≤1000cfu/g.
4. health food according to claim 1 is characterized in that its preparation is any one formulation that pharmaceutically allows.
5. health food according to claim 4 is characterized in that its formulation is chewable tablet, capsule, oral liquid or granule.
6. the preparation technology of health food as claimed in claim 1 is characterized in that comprising the following step:
200 mesh sieves were pulverized in matrimony vine 50-70 ℃ oven dry, added Bilberry fruit P.E, Rosa roxburghii juice freeze-dried powder then in proportion, mixed, and adopted the non high temperature preparation process that is no more than 60 ℃ to make required formulation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100956285A CN100387154C (en) | 2005-11-25 | 2005-11-25 | Health-care food for relieving-vision fatigue and its prepn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100956285A CN100387154C (en) | 2005-11-25 | 2005-11-25 | Health-care food for relieving-vision fatigue and its prepn. method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1785053A CN1785053A (en) | 2006-06-14 |
| CN100387154C true CN100387154C (en) | 2008-05-14 |
Family
ID=36782731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100956285A Expired - Fee Related CN100387154C (en) | 2005-11-25 | 2005-11-25 | Health-care food for relieving-vision fatigue and its prepn. method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100387154C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101015628B (en) * | 2006-11-18 | 2011-05-25 | 薛鹏景 | Chinese medicine for improving eyesight |
| CN101292736B (en) * | 2008-06-02 | 2012-06-06 | 北方绿色食品股份有限公司 | Blueberry tablet and preparation method thereof |
| CN103494134B (en) * | 2013-08-28 | 2015-06-24 | 沈阳农业大学 | Blueberry lozenge for relieving asthenopia and preparation method thereof |
| CN104383116B (en) * | 2014-12-01 | 2016-01-20 | 宁夏农林科学院 | A kind of black Fructus Lycii tablet |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100904A (en) * | 1994-05-27 | 1995-04-05 | 张进 | Nourishing liquor of Arctostaphylos Uva-ursi Spreng and preparation method thereof |
| CN1429563A (en) * | 2001-12-30 | 2003-07-16 | 深圳市海王眼之宝科技有限公司 | Plant extract composition for preventing and treating myopia and sight fatigne and its preparation method |
| CN1507813A (en) * | 2002-12-15 | 2004-06-30 | 李宗宝 | Composite nutrient food and processing method thereof |
-
2005
- 2005-11-25 CN CNB2005100956285A patent/CN100387154C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1100904A (en) * | 1994-05-27 | 1995-04-05 | 张进 | Nourishing liquor of Arctostaphylos Uva-ursi Spreng and preparation method thereof |
| CN1429563A (en) * | 2001-12-30 | 2003-07-16 | 深圳市海王眼之宝科技有限公司 | Plant extract composition for preventing and treating myopia and sight fatigne and its preparation method |
| CN1507813A (en) * | 2002-12-15 | 2004-06-30 | 李宗宝 | Composite nutrient food and processing method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1785053A (en) | 2006-06-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101695376B (en) | Health-care food for preventing diabetes | |
| CN104435775B (en) | A kind of Traditional Chinese medicinal health-care wine and preparation method thereof | |
| CN110447902B (en) | Composition with weight-losing effect | |
| CN105362501A (en) | Radiation-preventing and eyesight-protecting beverage, and preparation method thereof | |
| CN105233100A (en) | Drink for treating diabetes and preparation method thereof | |
| CN105232907A (en) | Beverage capable of invigorating kidney and strengthening Yang and making method thereof | |
| CN110051815A (en) | A kind of auxiliary hyperglycemic food ball and preparation method thereof | |
| CN108157575A (en) | A kind of pressed candy for alleviating visual fatigue and preparation method and application | |
| CN105124605A (en) | Health care chewable tablet and preparation method thereof | |
| CN105124347A (en) | Moringa oleifera blood-glucose-reducing composition and preparation method thereof | |
| CN105030877A (en) | Healthcare food for relieving asthenopia and preparation method thereof | |
| CN106491947B (en) | A kind of composition for relieving asthenopia and its preparation | |
| CN100387154C (en) | Health-care food for relieving-vision fatigue and its prepn. method | |
| CN100486456C (en) | Health-care food used for reliefing eyestrain, and its preparing method | |
| CN116531444B (en) | Cough-relieving lung-heat-clearing soft capsule and preparation process thereof | |
| CN106177223A (en) | A kind of have compositions alleviating asthenopia function and preparation method thereof | |
| CN102579896B (en) | Natural Chinese herbal medicine anticancer pill | |
| CN102090637A (en) | Collagen-containing compound nutritious powder | |
| CN106578323A (en) | Eyesight-improving functional ice cream and preparation method thereof | |
| CN105994740A (en) | Green tea with dendrobium officinale and method for preparing green tea | |
| CN110024941A (en) | A kind of composition and its application with blood-enrich function | |
| KR101095834B1 (en) | Natural tea composition prescribed based on patient's physical constitution | |
| CN104055115B (en) | A kind of health products containing agate coffee, the stem of noble dendrobium and Panax Japonicus Var. Major and preparation method thereof | |
| CN107212402B (en) | Blood pressure lowering food and preparation method thereof | |
| CN109259230A (en) | Comprising jerusalem artichoke He the food compositions and the preparation method and application thereof of Amorphophalus rivieri extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: NANJING ZHONGKE PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: NANJING ZHONGKE GROUP CO., LTD. Effective date: 20110321 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 210008 20/F, HEPING BUILDING, NO. 22, BEIJING EAST ROAD, NANJING CITY, JIANGSU PROVINCE TO: 211102 NO. 8, ZHONGKE ROAD, JIANGNING ECONOMIC AND TECHNOLOGICAL DEVELOPMENT ZONE, NANJING CITY, JIANGSU PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20110321 Address after: Nanjing City, Jiangsu Province Branch Road 211102 Jiangning economic and Technological Development Zone No. 8 Patentee after: NANJING ZHONGKE PHARMACEUTICAL Co.,Ltd. Address before: 210008, Heping building, No. 22, Beijing East Road, Jiangsu, Nanjing, 20 Patentee before: Nanjing Zhongke Group Co.,Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080514 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |