CN100381822C - Automatic analyzer for G6PD and mediterranean anemia - Google Patents
Automatic analyzer for G6PD and mediterranean anemia Download PDFInfo
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- CN100381822C CN100381822C CNB031136389A CN03113638A CN100381822C CN 100381822 C CN100381822 C CN 100381822C CN B031136389 A CNB031136389 A CN B031136389A CN 03113638 A CN03113638 A CN 03113638A CN 100381822 C CN100381822 C CN 100381822C
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Abstract
The present invention relates to an automatic analyzer for G6PD and mediterranean anemia, which is composed of a cabinet, a work bench, a transverse feed mechanism, a longitudinal feed mechanism, an upper feed mechanism, a lower feed mechanism, an upright post, an electric control part, etc., wherein the cabinet is provided with a light emission detecting device, a quantitative pipettor, an operating panel and a control system; the work bench is provided with a sample placing seat, a reagent box, a cleaning box and a test tube seat; the transverse feed mechanism is provided with a stepping motor which causes the transverse feed mechanism to move, a synchronous belt pulley driving set, a linear ball guide rail, a control switch, etc.; the longitudinal feed mechanism is provided with a stepping motor which causes a continuous pipette suction head to move from top to bottom, a synchronous belt driving set, a linear ball guide rail, a control switch, etc.; the upper feed mechanism and the lower feed mechanism are composed of a stepping motor which causes the continuous pipette suction head to move from top to bottom, a ball lead screw pair, a linear ball guide rail, a control switch, etc. The present invention has the advantages of quantitative suction and the transfer of samples, automatic and quantitative addition of reagents, automatic cleaning, automatic heating and heat preservation, automatic analysis and reading for 20 pairs of light density values, and required data printing. The present invention can select the variety of the detection and the program of the sample number according to requirements.
Description
Technical field
The present invention relates to bio-engineering research, clinical definite, used glucose 6-phosphate dehydrogenase (being called for short G6PD) and the thalassemia automatic analyzer of gene diagnosis, particularly a kind of analytical instrument that manual distributing operation becoming robotization is detected.
Background technology
Glucose 6-phosphate dehydrogenase (being called for short G6PD) and thalassemia automatic analyzer are used in general population, adult's pre-marital medical check-up, produce inspection and neonate's glucose 6-phosphate dehydrogenase (being called for short G6PD) deficiency disease examination and thalassemia examination.Also can be used in the positive or doubtful positive object that other method examination is gone out and make a definite diagnosis, or be used for the case that clinical needs are made a definite diagnosis the haemolysis reason.
China glucose 6-phosphate dehydrogenase (being called for short G6PD) and thalassemia blood examination method are manual dosings at present, adopt spectrophotometer one by one the reaction of blood sample to be detected than colourity then, the accuracy and the reliability of operation are more difficult to get assurance, efficient is low, and present manual frequency is 50 sample/every days.Along with the continuous development of computer technology and biotechnology, require to adopt self-reacting device detect glucose 6-phosphate dehydrogenase (being called for short G6PD) and thalassemic require imperative.
Summary of the invention
The purpose of this invention is to provide a kind of automated analysis instrument, improve blood test automatization level, standard blood examination operation, can alleviate labor intensity of operating personnel greatly and increase work efficiency, reduce human factor mistake, improve hospital's class and image, control and reduction neonate inborn defect rate, reach prenatal and postnatal care, improve the overall quality of newborns.
The present invention solves by following scheme: described glucose 6-phosphate dehydrogenase and thalassemia automatic analyzer are made up of the mechanical part and the collecting of electrical controls, its mechanical part comprises: a cabinet, cabinet is built-in with quantitative pipettor, and cabinet top box face is provided with optical detection device, guidance panel and control system; And one place having specimen holder, kit, clean box and having the working plate of the test tube flat of heat radiation, cooling and heating function above the cabinet; Reach the column that places the cabinet left and right sides respectively, support has horizontal X crossbeam between the column, and the X crossbeam is provided with Y crossbeam longitudinally, and the Y crossbeam is provided with vertical Z vertical beam; Reach one and be installed on the bottom and top feed mechanism that suction nozzle on the upright Z beam, that be connected with quantitative pipettor moves up and down it; And one be installed on the Y crossbeam, be connected the longitudinal feed mechanism that it is vertically moved with above-mentioned bottom and top feed mechanism; And one install with the X crossbeam on, be connected with above-mentioned longitudinal feed mechanism and make its horizontal mobile transverse feed mechanism;
The feeding process of the X of above-mentioned suction nozzle, Y, three feed mechanisms of Z and quantitatively pipettor get the liquid dosing by collecting of electrical controls control with to the optical detection device sample introduction, and the testing result of optical detection device is carried the telegram in reply control section, by collecting of electrical controls control output result.
Innovation part of the present invention is to use electromechanical integration and Computer Control Technology realizes that once liquid, heating automatically, insulation are handled, moved automatically to 40 data of 20 samples of check and analysis automatically, light detects a series of automatic control processes such as colorimetric automatically, distributed manual operation process is become centralized automation mechanized operation, and working routine can become standardization.So both alleviated labor intensity of operating personnel in a large number, automation mechanized operation will improve more than 5 times than manual efficient, reduces the mistake of human factor again.Operating personnel have just entered machine by start key again and have operated automatically as long as sample, reagent, cleaning solution, test tube, suction nozzle, an aquae destillata are put well in advance on correspondence position, finish with regard to auto stop until The whole analytical process.The optional different program of different operation processes, work are very simple, convenient.
Description of drawings
Fig. 1 glucose 6-of the present invention phosphate dehydrogenase and thalassemia automatic analyzer overall structural arrangement front view;
Fig. 2 glucose 6-of the present invention phosphate dehydrogenase and thalassemia automatic analyzer overall structural arrangement left view;
Fig. 3 glucose 6-of the present invention phosphate dehydrogenase and thalassemia automatic analyzer light detection architecture arrangenent diagram;
The quantitative pipettor structural plan of Fig. 4 glucose 6-of the present invention phosphate dehydrogenase and thalassemia automatic analyzer;
Fig. 5 glucose 6-of the present invention phosphate dehydrogenase and thalassemia automatic analyzer circuit block diagram.
Embodiment
Automatic analyzer of the present invention is made up of the mechanical part and the collecting of electrical controls.
As Figure 1A-B, shown in Figure 2, arrange synoptic diagram for the physical construction of glucose 6-phosphate dehydrogenase (being called for short G6PD) and thalassemia automatic analyzer, it is by cabinet 1, working plate 2, specimen holder 3, kit 4, clean box 5, test tube flat 6, optical detection device 7, suction nozzle 8, column 9, X crossbeam 10, main synchronizing wheel 11, control position switch 12, be with 13 synchronously, Y stepping motor 14, guard shield 15, from synchronizing wheel 16, heating radiator 17, refrigeratory 18, well heater 19, quantitative pipettor 20, flexible pipe 21, straight ball-guide pays 22, X stepper motor 23, control position switch 24, main synchronizing wheel 25, straight ball-guide pays 26, Z stepper motor 27, ballscrews and nuts 28, straight ball-guide pays 29, Y crossbeam 30, be with 31 synchronously, from synchronizing wheel 32, Z beam 33, suction nozzle Connection Block 34, control position switch 35, bearing 36, guidance panel and control system 37, control casing 38 is formed.
As shown in Figure 3, optical detection device 7 mainly is made up of receiver 39, conveyer chain 40, colorimetric cup 41, cuvette 42, support foot 43, web joint 44, transmitter 45, reducing motor group 46, installing plate 47.Receiver 39, transmitter 45 are housed on web joint 44, web joint 44 is placed on the installing plate 47, reducing motor group 46, support foot 43 are housed below the installing plate 47, on mobile stepper motor 46, conveyer chain 40 is housed, colorimetric cup 41 is housed on conveyer chain 40, cuvette 42 is housed in colorimetric cup 41.
As shown in Figure 4, quantitatively pipettor 20 mainly be by stepper motor 48, bearing seat 49, bearing 50, ballscrews and nuts 51, straight ball-guide pay 52, pipettor suction nozzle 53, supporting base 54, flexible pipe 21 continuously, web joint 55 is formed.Be equipped with on web joint 55 that stepper motor 48, straight ball-guide pay 52, supporting base 54, on the output shaft of stepper motor 48, be set with bearing 50, bearing 50 is contained in the bearing seat 49, the screw mandrel direct connection of the output shaft of stepper motor 48 and ballscrews and nuts 51, nut is installed in straight ball-guide and pays on 52, continuous pipettor suction nozzle 53 is housed on supporting base 54, and the piston rod of pipettor suction nozzle 53 is contained on the nut continuously.
As shown in Figure 5, be the circuit side connector block diagram of the collecting of electrical controls, the collecting of electrical controls comprises that 89C51 single-chip microcomputer, LCD MODULE, keyboard input circuit, three expansion interface chips 8255, A/D A/D conversion circuit, serial electricity erasable memorizer, 16 road light emitting diode display circuits, multichannel light are every imput output circuit, multipath solid-state relay and relay output circuit, four road stepper motor driving circuits, RS232 serial communication interface, well heater, printer connecting circuit, power down start-up circuit, 373 latch circuits.
Low eight bit data/the address wire of said 89C51 single-chip microcomputer is connected with the eight bit data line of minimum two of the input end of 373 latchs, expansion interface chip 8255, minimum two address wire A1～A0 that connect expansion interface chips 8255 of the output of 373 latchs are used to select the internal port of expansion interface chip 8255.The Senior Three position of the high address line of 89C51 single-chip microcomputer connects 138 code translators, and its output connects the sheet choosing end of three expansion interface chips 8255 respectively.Three expansion interface chips 8255 are connected with following three part peripheral signal respectively: expansion interface chip 8255-1 is connected keyboard input circuit and liquid crystal display circuit; Expansion interface chip 8255-2 makes delivery outlet, shows as output signal, and the signal of control and driving topworks is used; Expansion interface chip 8255-3 connects the input port of printer interface and input signal and uses; The 89C51 single-chip microcomputer is connected with the serial electricity erasable memorizer; The 89C51 single-chip microcomputer is isolated respectively and the A/D A/D conversion circuit by photoelectricity, and four road stepper motor driving circuits connect, and also are connected with power down start-up circuit, 373 latchs.
The circuit function of each unit is: the 89C51 single-chip microcomputer is central calculation process control section; directly connecting the serial electricity erasable memorizer is the datamation district (but power down protected data) of its operation usefulness; so that expand more I/O input/output port, select the internal port and the chip select address of three expansion interface chips 8255 respectively by connecting 373 latchs and 138 code translators (not marking among the figure) by the 89C51 single-chip microcomputer by connecting three expansion interface chips 8255 for the 89C51 single-chip microcomputer.Expansion interface chip 8255-1 is connected with LCD MODULE, keyboard input circuit, realizes man-machine conversation, and different parameters can be set, and selects different trace routine and manual operation function, shows the various signals of testing process.Expansion interface chip 8255-2 connects 16 road light emitting diode display circuits and makes various pilot lamp or make output signal usefulness, and other 8 the tunnel make output control, drive signal usefulness, connect the control of well heater and other external equipment switches.Expansion interface chip 8255-3 is the printer connector and makes multichannel input detection signal connector.The 89C51 single-chip microcomputer is isolated by photoelectricity and is connected the A/D A/D conversion circuit respectively, and four road stepper motor driving circuits reach Stepping Motor Control to realize temperature detection.It is to use when preserving data necessary when the power down of needs is arranged that the 89C51 single-chip microcomputer connects the power down start-up circuit.
The course of work of above-described automatic analyzer is as follows:
Glucose 6-phosphate dehydrogenase (being called for short G6PD) and 20 samples of the once maximum processing of thalassemia automatic analyzer.Its principle of work: at first selected a certain program (as glucose 6-phosphate dehydrogenase), operating personnel are with sample, suction nozzle, testing tube, reagent, cleaning fluid, cuvette, aquae destillata is placed on the corresponding position, press start key then, machine enters automatic mode, finishes automatically by selection procedure: (1) suction nozzle is from the former coordinate X that presses of instrument, Y moves to (3) suction nozzle that resets after the fast quantitatively imbibition of A reagent station (2) suction nozzle F.F. Z and presses coordinate X, Y moves to (5) suction nozzle that resets after the fast discharge opeing of No. 1 testing tube of 1 test station (4) suction nozzle F.F. Z and repeats 1 No. 1-No. 20 by sequence number)-4) work (6) suction nozzle presses coordinate X, Y moves to the cleaning solution station and draws (7) suction nozzle that resets after the cleaning solution and move to by coordinate Y and retreat to original position (9) suction nozzle soon after the fast discharge opeing of blowdown station (8) suction nozzle F.F. Z and press coordinate X, Y moves to B liquid station (10) suction nozzle F.F. Z and inhales soon and retreat to original position (11) suction nozzle soon behind the B liquid and press coordinate X, Y moves to reset after the fast discharge opeing of No. 1 testing tubes of 2 test station (12) suction nozzle F.F. Z and repeats picture and inhale A liquid work (13) suction nozzle and press coordinate X, Y moves to No. 1 dilution of dilution blood station blood sample pipe (14) suction nozzle F.F. Z and inhales soon and retreat to original position (15) suction nozzle soon behind the dilute blood and press coordinate X, Y moves to the fast imbibition of No. 1 testing tube of 1 test station (16) suction nozzle F.F. Z, discharge opeing is imbibition again, retreat to original position (17) suction nozzle after the discharge opeing soon and press coordinate X, Y moves to No. 1 dilution of dilution blood station blood sample pipe (18) suction nozzle F.F. Z and inhales soon and retreat to original position (19) suction nozzle soon behind the dilute blood and press coordinate X, Y moves to the fast imbibition of No. 1 testing tubes of 2 test station (20) suction nozzle F.F. Z, discharge opeing is imbibition again, retreat to original position (21) suction nozzle after the discharge opeing soon and press coordinate X, Y move to the cleaning solution station draw (22) suction nozzle that resets after the cleaning solution move to by coordinate Y retreat to original position (24) suction nozzle soon after the fast discharge opeing of blowdown station (23) suction nozzle F.F. Z and repeat 13 No. 1-No. 20 by sequence number)-23) work (25) 1 test station, 2 test station are heated to 20 minutes (26) suction nozzles of 37 ℃ of incubations simultaneously and press coordinate X, Y moves to C liquid station (27) suction nozzle F.F. Z and inhales soon and retreat to original position (28) suction nozzle soon behind the C liquid and press coordinate X, Y moves and respectively C liquid is moved to No. 1-No. 20 testing tubes of 1 test station and No. 1-No. 20 testing tubes of 2 test station.(29) suction nozzle moves by coordinate X, Y and respectively the mixed liquor in No. 1-No. 20 testing tubes of 1 test station and No. 1-No. 20 testing tubes of 2 test station is moved in the cuvette (30) and read 20 pairs of optical density value.Repeat above-mentioned operation, work is carried out in circulation constantly.
Claims (6)
1. glucose 6-phosphate dehydrogenase and thalassemia automatic analyzer are made up of the mechanical part and the collecting of electrical controls, and it is characterized in that: its mechanical part comprises:
One cabinet (1), cabinet (1) is built-in with quantitative pipettor (20), optical detection device (7), guidance panel and control system (37),
And one place having specimen holder (3), kit (4), clean box (5) and having the working plate (2) of the test tube flat (6) of heat radiation, cooling and heating function above the cabinet (1),
Reach the column (9) that places cabinet (1) left and right sides respectively, support has horizontal X crossbeam (10) between the column, and X crossbeam (10) is provided with Y crossbeam (30) longitudinally, and Y crossbeam (30) is provided with vertical Z vertical beam (33),
And one be installed on suction nozzle on the upright Z vertical beam (33), that be connected with quantitative pipettor (8) and make its bottom and top feed mechanism that moves up and down,
And one be installed on the Y crossbeam (30), be connected with above-mentioned bottom and top feed mechanism and make its longitudinal feed mechanism that vertically moves,
And one install with X crossbeam (10) on, be connected with above-mentioned longitudinal feed mechanism and make its horizontal mobile transverse feed mechanism;
The feeding process of the X of above-mentioned suction nozzle, Y, three feed mechanisms of Z and quantitatively pipettor get the liquid dosing by collecting of electrical controls control with to the optical detection device sample introduction, and the testing result of optical detection device is carried the telegram in reply control section, by collecting of electrical controls control output result.
2. by claim 1 described glucose 6-phosphate dehydrogenase and thalassemia automatic analyzer, it is characterized in that: described laterally or longitudinal feed mechanism is installed in respectively laterally or longitudinally on X, the Y crossbeam (10,30), synchronous pulley group, straight ball-guide that they drive by X, Y stepping motor (23,14), by X, Y stepping motor are respectively paid (22,26), and are installed on laterally or the position controlling switch (12,24) at lengthwise position two ends is formed.
3. by claim 1 described glucose 6-phosphate dehydrogenase and thalassemia automatic analyzer, it is characterized in that: described bottom and top feed mechanism is installed on the upright Z beam (33), it is by Z stepper motor (27) and be sleeved on ballscrews and nuts (28) on Z stepper motor (27) output shaft, and position controlling switch (35) composition that is installed in upper/lower terminal, suction nozzle (8) suction nozzle Connection Block (34) is housed is installed on the nut of ballscrews and nuts (28).
4. by claim 1 described glucose 6-phosphate dehydrogenase and thalassemia automatic analyzer, it is characterized in that: described optical detection device (7) mainly is made up of receiver (39), conveyer chain (40), colorimetric cup (41), cuvette (42), support foot (43), web joint (44), transmitter (45), reducing motor group (46), installing plate (47).Receiver (39), transmitter (45) are housed on web joint (44), web joint (44) is placed on the installing plate (47), reducing motor group (46), support foot (43) are housed below the installing plate (47), conveyer chain (40) is housed on reducing motor group (46), colorimetric cup (41) is housed on conveyer chain (40), cuvette (42) is housed in colorimetric cup (41).
5. by claim 1 described glucose 6-phosphate dehydrogenase and thalassemia automatic analyzer, it is characterized in that: described quantitative pipettor (20) mainly is to pay (52), continuous pipettor suction nozzle (53), supporting base (54), flexible pipe (21) by stepper motor (48), bearing seat (49), bearing (50), ballscrews and nuts (51), straight ball-guide, and web joint (55) is formed.Stepper motor (48) is housed on web joint (55), straight ball-guide is paid (52), supporting base (54), on the output shaft of stepper motor (48), be set with bearing (50), bearing (50) is contained in the bearing seat (49), the screw mandrel direct connection of the output shaft of stepper motor (48) and ballscrews and nuts (51), nut is installed in straight ball-guide and pays on (52), continuous pipettor suction nozzle (53) is housed on supporting base (54), and the piston rod of pipettor suction nozzle (54) is contained on the nut continuously.
6. by claim 1 described glucose 6-phosphate dehydrogenase and thalassemia automatic analyzer, it is characterized in that: the described collecting of electrical controls comprises the 89C51 single-chip microcomputer, LCD MODULE, the keyboard input circuit, three expansion interface chips 8255, the A/D A/D conversion circuit, the serial electricity erasable memorizer, 16 road light emitting diode display circuits, multichannel light is every imput output circuit, the multipath solid-state relay, the relay output circuit, four road stepper motor driving circuits, the RS232 serial communication interface, well heater, the printer connecting circuit, the power down start-up circuit, 373 latch circuits; Minimum two of the low eight bit data/address wire of wherein said 89C51 single-chip microcomputer and the input end of 373 latchs, the eight bit data line of expansion interface chip 8255 is connected, minimum two connections of the output of 373 latchs, the address wire A1 of expansion interface chip 8255～A0, be used to select the internal port of expansion interface chip 8255, the Senior Three position of the high address line of 89C51 single-chip microcomputer connects 138 code translators, its output connects the sheet choosing end of three expansion interface chips 8255 respectively, and three expansion interface chips 8255 are connected with following three part peripheral signal respectively: expansion interface chip 8255-1 is connected keyboard input circuit and liquid crystal display circuit; Expansion interface chip 8255-2 makes delivery outlet, shows as output signal, and the signal of control and driving topworks is used; Expansion interface chip 8255-3 connects the input port of printer interface and input signal and uses; The 89C51 single-chip microcomputer is connected with the serial electricity erasable memorizer; The 89C51 single-chip microcomputer is isolated by photoelectricity and is connected with A/D A/D conversion circuit, four road stepper motor driving circuits respectively, also is connected with power down start-up circuit, 373 latchs.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB031136389A CN100381822C (en) | 2003-01-22 | 2003-01-22 | Automatic analyzer for G6PD and mediterranean anemia |
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| CNB031136389A CN100381822C (en) | 2003-01-22 | 2003-01-22 | Automatic analyzer for G6PD and mediterranean anemia |
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| CN1431515A CN1431515A (en) | 2003-07-23 |
| CN100381822C true CN100381822C (en) | 2008-04-16 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102095628A (en) * | 2010-12-02 | 2011-06-15 | 北京普立泰科仪器有限公司 | Sample digestion processing device |
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| CN102095628B (en) * | 2010-12-02 | 2013-04-17 | 北京普立泰科仪器有限公司 | Sample digestion processing device |
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| CN1431515A (en) | 2003-07-23 |
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Address after: 510663 No.3, scientific research road, Science City, Guangzhou high tech Industrial Development Zone, Guangzhou, Guangdong Province Patentee after: GUANGZHOU Research Institute OF OPTICS MECHANICS ELECTRICITY TECHNOLOGY Address before: 510630 Guangdong city of Guangzhou province Tianhe District Longkou Shipai Road No. 36 Patentee before: Guangzhou optical mechanical and electrical engineering research and Development Center |
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Effective date of registration: 20200603 Address after: 510663 No.3, scientific research road, Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee after: Optical mechanical and electrical (Guangzhou) Research Institute Co.,Ltd. Address before: 510663 No.3, scientific research road, Science City, Guangzhou high tech Industrial Development Zone, Guangzhou, Guangdong Province Patentee before: GUANGZHOU Research Institute OF OPTICS MECHANICS ELECTRICITY TECHNOLOGY |
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| CX01 | Expiry of patent term |
Granted publication date: 20080416 |