CN100341506C - 含有阿斯匹林的药用组合物 - Google Patents
含有阿斯匹林的药用组合物 Download PDFInfo
- Publication number
- CN100341506C CN100341506C CNB018227686A CN01822768A CN100341506C CN 100341506 C CN100341506 C CN 100341506C CN B018227686 A CNB018227686 A CN B018227686A CN 01822768 A CN01822768 A CN 01822768A CN 100341506 C CN100341506 C CN 100341506C
- Authority
- CN
- China
- Prior art keywords
- pharmacology
- acceptable salt
- aspirin
- pyridine
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Description
给予化合物 | 血栓重量(mg) | 抑制率(%) | |
化合物A(mg/kg) | 阿斯匹林(mg/kg) | ||
000.30.60.30.6 | 010001010 | 52.3±1.246.6±2.843.5±2.137.5±2.130.5±3.523.2±3.8 | -12.3±4.417.0±4.128.3±4.041.8±6.655.7±7.2 |
Claims (8)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP392983/00 | 2000-12-25 | ||
JP392983/2000 | 2000-12-25 | ||
JP2000392983 | 2000-12-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1491109A CN1491109A (zh) | 2004-04-21 |
CN100341506C true CN100341506C (zh) | 2007-10-10 |
Family
ID=18858878
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB018227686A Expired - Lifetime CN100341506C (zh) | 2000-12-25 | 2001-12-20 | 含有阿斯匹林的药用组合物 |
Country Status (26)
Country | Link |
---|---|
US (3) | US20040024013A1 (zh) |
EP (1) | EP1350511B1 (zh) |
KR (1) | KR100692934B1 (zh) |
CN (1) | CN100341506C (zh) |
AT (1) | ATE407675T1 (zh) |
AU (1) | AU2002217464B2 (zh) |
BR (1) | BR0116531A (zh) |
CA (1) | CA2432644C (zh) |
CY (1) | CY1108626T1 (zh) |
CZ (1) | CZ297570B6 (zh) |
DE (1) | DE60135780D1 (zh) |
DK (1) | DK1350511T3 (zh) |
ES (1) | ES2311498T3 (zh) |
HK (1) | HK1056118A1 (zh) |
HU (1) | HUP0400644A3 (zh) |
IL (2) | IL156456A0 (zh) |
MX (1) | MXPA03005770A (zh) |
NO (1) | NO20032902D0 (zh) |
NZ (1) | NZ526540A (zh) |
PL (1) | PL206138B1 (zh) |
PT (1) | PT1350511E (zh) |
RU (1) | RU2262933C2 (zh) |
SK (1) | SK287972B6 (zh) |
TW (1) | TWI293249B (zh) |
WO (1) | WO2002051412A1 (zh) |
ZA (1) | ZA200304878B (zh) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1214031C (zh) * | 2000-07-06 | 2005-08-10 | 三共株式会社 | 氢化吡啶衍生物酸加成盐 |
MXPA03005770A (es) | 2000-12-25 | 2003-09-10 | Sankyo Co | Composiciones medicinales que contienen aspirina. |
WO2004098713A2 (en) * | 2003-05-05 | 2004-11-18 | Eli Lilly And Company | Treating cardiovascular diseases with a compound of formula (i) (cs 747 - prasugrel; rn 150322-43-4) |
CN100488163C (zh) * | 2005-01-19 | 2009-05-13 | 华为技术有限公司 | 组播业务处理方法和*** |
BRPI0612624A2 (pt) * | 2005-06-17 | 2016-11-29 | Lilly Co Eli | métodos para tratar doença vascular em um humano, e para prevenção e/ou tratamento de uma doença induzida por trombose ou uma doença induzida por tromboembolismo em um humano, e, uso de um composto |
DE102005029612A1 (de) * | 2005-06-23 | 2007-01-04 | Hochschule Bremen | Vorrichtung zum Erzeugen eines Panoramabildes |
WO2007024472A2 (en) * | 2005-08-19 | 2007-03-01 | Eli Lilly And Company | USE OF PAR- l/PAR- 4 INHIBITORS FOR TREATING OR PREVENTING VASCULAR DISEASES |
US20100204470A1 (en) * | 2006-06-27 | 2010-08-12 | Sandoz Ag | method for salt preparation |
TWI405591B (zh) * | 2006-12-07 | 2013-08-21 | Daiichi Sankyo Co Ltd | 固形製劑之製造方法 |
EP2100610A4 (en) * | 2006-12-07 | 2009-12-02 | Daiichi Sankyo Co Ltd | PHARMACEUTICAL COMPOSITION WITH LOW SUBSTITUTED HYDROXYPROPYL CELLULOSE |
US20090291138A1 (en) * | 2006-12-07 | 2009-11-26 | Daiichi Sankyo Company, Limited | Film-coated preparation having improved stability |
EP2100607A4 (en) * | 2006-12-07 | 2010-01-06 | Daiichi Sankyo Co Ltd | PHARMACEUTICAL COMPOSITION HAVING ENHANCED STORAGE STABILITY |
KR101442862B1 (ko) * | 2006-12-07 | 2014-09-22 | 다이이찌 산쿄 가부시키가이샤 | 만니톨 또는 유당을 함유하는 고형 제제 |
MY151726A (en) * | 2007-03-02 | 2014-06-30 | Daiichi Sankyo Co Ltd | Process for production of prasugrel hydrochloride having high purity |
HUE053158T2 (hu) | 2007-04-27 | 2021-06-28 | Cydex Pharmaceuticals Inc | Clopidogrelt és szulfoalkiléter ciklodextrint tartalmazó készítmények és alkalmazási eljárások |
CN101177430A (zh) * | 2007-12-11 | 2008-05-14 | 鲁南制药集团股份有限公司 | 氢化吡啶衍生物及其盐的制备方法 |
US20090281136A1 (en) * | 2008-05-08 | 2009-11-12 | Sandeep Mhetre | Prasugrel pharmaceutical formulations |
JP2011529859A (ja) | 2008-08-02 | 2011-12-15 | ルナン ファーマシューティカル グループ コーポレーション | プラスグレル重硫酸塩及びその薬物組成物並びにその応用 |
PL3100728T3 (pl) | 2009-05-13 | 2020-05-18 | Cydex Pharmaceuticals, Inc. | Kompozycje farmaceutyczne zawierające prasugrel i pochodne cyklodekstryny oraz sposoby ich wytwarzania i zastosowania |
CN102228691A (zh) * | 2011-06-29 | 2011-11-02 | 北京阜康仁生物制药科技有限公司 | 阿司匹林和一种抗血小板药物的药物组合物 |
US9757395B2 (en) * | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
US9757529B2 (en) | 2012-12-20 | 2017-09-12 | Otitopic Inc. | Dry powder inhaler and methods of use |
WO2014178891A1 (en) | 2013-04-30 | 2014-11-06 | Otitopic Inc. | Dry powder formulations and methods of use |
CN112656780A (zh) | 2014-02-20 | 2021-04-16 | 奥迪托皮克股份有限公司 | 用于吸入的干粉制剂 |
WO2016122421A1 (en) | 2015-01-29 | 2016-08-04 | Pharmactive Ilaç Sanayi Ve Ticaret A.Ş. | Stable pharmaceutical compositions containing prasugrel base |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1211922A (zh) * | 1996-02-19 | 1999-03-24 | 萨诺费公司 | 含有氯吡格雷和一种抗血栓形成药活性成分的新的组合物 |
CN1227100A (zh) * | 1999-01-26 | 1999-09-01 | 广东药学院 | 一种治疗、预防血栓形成及中风的复方制剂及其制备方法 |
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US3890240A (en) * | 1966-11-28 | 1975-06-17 | Pitney Bowes Inc | Toner compositions and methods for their preparation |
FR2215948B1 (zh) | 1973-02-01 | 1976-05-14 | Centre Etd Ind Pharma | |
FR2345150A2 (fr) | 1975-08-06 | 1977-10-21 | Centre Etd Ind Pharma | Nouveaux derives de la thienopyridine, et leur application |
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IT1306980B1 (it) | 1999-01-13 | 2001-10-11 | Magneti Marelli Spa | Gruppo motore-cambio di velocita', in particolare per motocicli. |
JP2000266780A (ja) | 1999-03-18 | 2000-09-29 | Matsushita Electric Ind Co Ltd | プローブカードとそれを用いた検査装置 |
IT1311924B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
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CN1214031C (zh) * | 2000-07-06 | 2005-08-10 | 三共株式会社 | 氢化吡啶衍生物酸加成盐 |
JP4001199B2 (ja) | 2000-07-06 | 2007-10-31 | 第一三共株式会社 | ヒドロピリジン誘導体酸付加塩 |
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MXPA03005770A (es) | 2000-12-25 | 2003-09-10 | Sankyo Co | Composiciones medicinales que contienen aspirina. |
WO2003011824A1 (en) * | 2001-07-31 | 2003-02-13 | Bristol-Myers Squibb Company | Bicyclic modulators of androgen receptor function |
DE10305984A1 (de) * | 2003-02-13 | 2004-09-02 | Helm Ag | Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen |
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-
2001
- 2001-12-20 MX MXPA03005770A patent/MXPA03005770A/es active IP Right Grant
- 2001-12-20 CZ CZ20031660A patent/CZ297570B6/cs not_active IP Right Cessation
- 2001-12-20 DK DK01271850T patent/DK1350511T3/da active
- 2001-12-20 CA CA2432644A patent/CA2432644C/en not_active Expired - Lifetime
- 2001-12-20 BR BR0116531-3A patent/BR0116531A/pt not_active Application Discontinuation
- 2001-12-20 CN CNB018227686A patent/CN100341506C/zh not_active Expired - Lifetime
- 2001-12-20 ES ES01271850T patent/ES2311498T3/es not_active Expired - Lifetime
- 2001-12-20 AT AT01271850T patent/ATE407675T1/de active
- 2001-12-20 RU RU2003118638/15A patent/RU2262933C2/ru active
- 2001-12-20 KR KR1020037008323A patent/KR100692934B1/ko active IP Right Grant
- 2001-12-20 DE DE60135780T patent/DE60135780D1/de not_active Expired - Lifetime
- 2001-12-20 WO PCT/JP2001/011201 patent/WO2002051412A1/ja active IP Right Grant
- 2001-12-20 NZ NZ526540A patent/NZ526540A/en not_active IP Right Cessation
- 2001-12-20 EP EP01271850A patent/EP1350511B1/en not_active Revoked
- 2001-12-20 AU AU2002217464A patent/AU2002217464B2/en not_active Expired
- 2001-12-20 PT PT01271850T patent/PT1350511E/pt unknown
- 2001-12-20 HU HU0400644A patent/HUP0400644A3/hu not_active Application Discontinuation
- 2001-12-20 IL IL15645601A patent/IL156456A0/xx active IP Right Grant
- 2001-12-20 SK SK754-2003A patent/SK287972B6/sk not_active IP Right Cessation
- 2001-12-20 PL PL363183A patent/PL206138B1/pl unknown
- 2001-12-25 TW TW090132160A patent/TWI293249B/zh not_active IP Right Cessation
-
2003
- 2003-06-16 IL IL156456A patent/IL156456A/en unknown
- 2003-06-20 US US10/600,266 patent/US20040024013A1/en active Granted
- 2003-06-23 ZA ZA200304878A patent/ZA200304878B/en unknown
- 2003-06-24 NO NO20032902A patent/NO20032902D0/no unknown
- 2003-11-19 HK HK03108414.8A patent/HK1056118A1/xx not_active IP Right Cessation
-
2006
- 2006-09-13 US US11/520,168 patent/US8404703B2/en not_active Expired - Fee Related
-
2008
- 2008-01-03 US US12/006,546 patent/US8569325B2/en not_active Expired - Fee Related
- 2008-12-02 CY CY20081101387T patent/CY1108626T1/el unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1211922A (zh) * | 1996-02-19 | 1999-03-24 | 萨诺费公司 | 含有氯吡格雷和一种抗血栓形成药活性成分的新的组合物 |
CN1227100A (zh) * | 1999-01-26 | 1999-09-01 | 广东药学院 | 一种治疗、预防血栓形成及中风的复方制剂及其制备方法 |
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