CN100335607C - Donkey-hid gelatin wine and production process thereof - Google Patents
Donkey-hid gelatin wine and production process thereof Download PDFInfo
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- CN100335607C CN100335607C CNB031568149A CN03156814A CN100335607C CN 100335607 C CN100335607 C CN 100335607C CN B031568149 A CNB031568149 A CN B031568149A CN 03156814 A CN03156814 A CN 03156814A CN 100335607 C CN100335607 C CN 100335607C
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Abstract
The present invention discloses a donkey-hide gelatin wine and a preparation method thereof. The preparation method comprises the following steps: firstly, donkey-hide gelatin blocks are pulverized into small blocks; then water is added to the small blocks, and the entire container is slightly heated until all the donkey-hide gelatin blocks are melted by heat; every 60 to 150g of melted donkey-hide gelatin liquid is added to every 10L of wines, and preliminary donkey-hide gelatin wines are obtained; and finished donkey-hide gelatin wines are obtained by cold storage, filtration and filling. The preparation method uses grain wines as solvents, melted donkey-hide gelatin is added to the grain wines, and the combination of the wines and the donkey-hide gelatin is smartly utilized to prepare the donkey-hide gelatin wines. The donkey-hide gelatin wine solves the problem of inconvenient administration of donkey-hide gelatin, and a method for eating the donkey-hide gelatin, which can be accepted by people easily is provided. The donkey-hide gelatin wine conforms to the conversion of novel concepts of consumers. Functional tests show that the donkey-hide gelatin wine has the function of immunological regulation. The preparation method has the advantages of simple steps and convenient implementation, and can be used for the industrial production.
Description
Technical field
The present invention relates to a kind of medicinal liquor and production method thereof, especially a kind of is raw material with the donkey-hide gelatin, attached medicinal liquor and the production method made from other herbal medicine thereof.Belong to the medicinal liquor field.
Background technology
Donkey-hide gelatin is qi-blood tonifying rare Chinese medicine, is the skin unhairing of equine species donkey after decoct to boil and form.The main component of donkey-hide gelatin is the various trace elements of collagen protein and hydrolysate, polypeptide, amino acid and needed by human.Theory of traditional Chinese medical science thinks that donkey-hide gelatin flavor is sweet, and property is flat, can be nourishing Yin and moistening lung, enrich blood, stop blooding.The modern pharmacology test shows that donkey-hide gelatin has cold resistant, and antifatigue, radioprotective, hypoxia tolerance, enhance immunity function and the effect that improves red corpuscle and hemoglobin content are a kind of ideal tonic Chinese medicines.
In the pharmacological experiment, respectively with physiological saline and donkey-hide gelatin solution to healthy mice continuous irrigation stomach after 5 days, under anoxic condition, the donkey-hide gelatin solution group survival time significantly is longer than the physiological saline group.Three groups of mouse after the administration are put in-18 ℃ of environment, observe its death condition, physiological saline group 100% death as a result, low, high two its mortality ratio of dosage group of donkey-hide gelatin solution group are respectively 60%, 40%, show that donkey-hide gelatin has the cold resistant effect, and the dose of increasing donkey-hide gelatin solution, the cold resistant effect strengthens.Two groups of mouse are carried out swimming test show that also donkey-hide gelatin solution can significantly strengthen the antifatigue effect of mouse.Get 30 of healthy mices, be divided into 3 groups at random, the first group is irritated donkey-hide gelatin solution 0.2ml/10g, and in irradiation
60Successive administration is 7 days before the gamma-rays of Co, and the second group is irritated donkey-hide gelatin solution 0.2ml/10g, and in pre-irradiation successive administration 3 days, control group was given the physiological saline of equivalent, and illuminate condition is: use
60Uniform irradiation of the gamma-rays whole body of Co, apart from 70mm, dosage 37 human relations/min, total dose 800 human relations, administration is continued in the irradiation back, observes the survival rate and the radio-protective of each treated animal in 30 days and renders a service, and the survival rate of first group is 70% as a result, and it is 2.81 that protection is renderd a service; The survival rate of second group is 20%, and it is 1.80 that protection is renderd a service; And the survival rate 0 of control group, it is 0 that protection is renderd a service.This shows that donkey-hide gelatin has very strong Antiradiation injury effect.The donkey-hide gelatin immunologic function test of passing through shows that donkey-hide gelatin has tangible effect of gain to spleen.Can obviously improve the phagocytic activity of Turnover of Mouse Peritoneal Macrophages after donkey-hide gelatin solution is oral, the difference (P＜0.01) of highly significant relatively be arranged with the physiological saline group.Get 16 of body weight 2-2.5kg rabbit, measure its Hb respectively, RBC, WBC and classification thereof, method with bloodletting makes it cause hemorrhagic anemia then, be divided into 2 groups then at random, the first group is irritated donkey-hide gelatin solution 3g/kg. second group and is irritated physiological saline, successive administration 9 days, administration is after 1 hour the last time, measure its blood picture more respectively, the result shows that donkey-hide gelatin solution group has rising Hb to the rabbit of hemorrhagic anemia, the effect of RBC and WBC, the mean of difference does not have significant difference (P＞0.05) before and after the treatment, and the physiological saline group is to the rabbit of the hemorrhagic anemia Hb that do not raise, RBC and WBC effect. the mean of difference has the difference (P＜0.001) of highly significant before and after the treatment, shows that donkey-hide gelatin oral has the effect of treatment hemorrhagic anemia.
Though donkey-hide gelatin has very many benefits, directly decoct, boiling the donkey-hide gelatin that forms is block blob of viscose, not soluble in water under the normal temperature, and directly takes inconvenience, also is unfavorable for the absorption of nutritive ingredient; Therefore to take inconvenience be a great problem to donkey-hide gelatin always, had a strong impact on using and promoting of donkey-hide gelatin.
The application of wine in people's daily life is very general, and the record of making the medicinal liquor disease preventing and treating with the steeping in wine soak medicine has been arranged very early.If donkey-hide gelatin can be combined with wine, can satisfy the needs that people drink, can reach disease preventing and treating again, improve the purpose of immunizing power, be certain to be subjected to people's welcome, obtain good economic and social benefit.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of donkey-hide gelatin wine, not only can solve the problem that donkey-hide gelatin is taken inconvenience, and have the adjusting immunologic function, the effect of strengthening immunity.
Another technical problem that the present invention will solve provides a kind of production method of donkey-hide gelatin wine, is used for producing above-mentioned donkey-hide gelatin wine, and this method steps is simple, and it is convenient to implement, and can be used for suitability for industrialized production.
Donkey-hide gelatin wine of the present invention, formulated in following ratio,
Donkey-hide gelatin 60-150g; Grain wine 10L;
Described donkey-hide gelatin 60-150g joins in the grain wine through after the molten, and making the cumulative volume of donkey-hide gelatin and grain wine is 10L, obtains first product donkey-hide gelatin wine of the present invention.
For the effect of the enhancing body immunity that increases donkey-hide gelatin wine, above-mentioned grain wine soaks in advance by following component glossy ganoderma, wolfberry fruit, the Radix Astragali or its combination and obtains, every 10L grain steeping in wine bubble:
Glossy ganoderma 50-200g;
And/or wolfberry fruit 200-600g;
And/or Radix Astragali 200-600g.
In order to extract the effective constituent in the above-mentioned Chinese medicine as far as possible, can be to the above-mentioned method of taking glossy ganoderma, wolfberry fruit, the Radix Astragali or its combination repeatedly to soak.
In order to increase the mouthfeel of wine, in aforesaid donkey-hide gelatin wine, added rock sugar.Add rock sugar 200-600g in every 10L donkey-hide gelatin wine.For some diabetics, unable to drink can adopt sweeting agent to replace rock sugar with the beverage that contains sugar part.
Donkey-hide gelatin method for preparing wine of the present invention comprises the steps:
Step 1, raw material donkey-hide gelatin piece is ground into fritter.The bulk donkey-hide gelatin of raw material is convenient to storage and transportation, but is unfavorable for that donkey-hide gelatin dissolves, and therefore need pulverize earlier.
After step 2, the fritter donkey-hide gelatin that step 1 is obtained add water, the more little donkey-hide gelatin piece that is heated to of entire container is all melted, become liquid donkey-hide gelatin liquid, this step is also referred to as the molten of donkey-hide gelatin.
Step 3, step 2 is obtained melting back donkey-hide gelatin liquid join in the wine liquid, add donkey-hide gelatin 60-150g in every 10L wine, obtain the donkey-hide gelatin wine of first product.
The production method of aforesaid donkey-hide gelatin wine, wine liquid in the described step 3 is through soaking the medicinal liquor of glossy ganoderma, wolfberry fruit, the Radix Astragali or its combination, add glossy ganoderma 50-200g in every 10L wine, and/or wolfberry fruit 200-600g, and/or Radix Astragali 200-600g twice sealing under 20-35 ℃ of condition soaked and to be obtained in 36-120 hour.
The production method of aforesaid donkey-hide gelatin wine has added the rock sugar solution that dissolves in the wine liquid in the described step 3, add rock sugar 200-600g in every 10L wine; Or add sweeting agent in the wine liquid in the described step 3.
The production method of aforesaid donkey-hide gelatin wine, the mixed wine liquid that step 3 is obtained carries out the cold storage of low temperature at-4 ℃-0 ℃; Then the wine liquid after the cold storage is filtered, remove the solid residue in the wine liquid; Promptly carry out can at last, obtain finished product donkey-hide gelatin wine filtering back wine liquid.
Donkey-hide gelatin wine of the present invention with the high wine that soaks glossy ganoderma, wolfberry fruit, the Radix Astragali as solvent, donkey-hide gelatin after the adding molten, utilized combining of drinks and donkey-hide gelatin cleverly, make donkey-hide gelatin wine, solve donkey-hide gelatin and taken inconvenient problem, make a kind of method that is easy to allow the edible donkey-hide gelatin that the people accepts, meet the transformation of human consumer's new concept.Donkey-hide gelatin wine of the present invention proves to have immunoregulation effect through functional experiment.Donkey-hide gelatin method for preparing wine of the present invention is used for producing above-mentioned donkey-hide gelatin wine, and this method steps is simple, and it is convenient to implement, and can be used for suitability for industrialized production.
Description of drawings
Fig. 1 is the schema of production method of the present invention.
Embodiment
Below in conjunction with drawings and Examples technical scheme of the present invention is elaborated.
Embodiment 1: present embodiment donkey-hide gelatin wine forms by following component configuration: in every 10L donkey-hide gelatin wine, comprise: donkey-hide gelatin 60-150g; Rock sugar 200-600g; Grain wine 10L.
Described donkey-hide gelatin 60-150g, joins in the grain wine after rock sugar 200-600g is dissolved in water through after the molten, and making the cumulative volume of donkey-hide gelatin and grain wine is 10L, obtains first product donkey-hide gelatin wine of the present invention.
Used grain wine soaks in advance by following component glossy ganoderma, wolfberry fruit, the Radix Astragali or its combination and obtains in the embodiment of the invention 1, every 10L grain steeping in wine bubble:
Glossy ganoderma 50-200g;
Wolfberry fruit 200-600g;
Radix Astragali 200-600g.
For some diabetics, can adopt sweeting agent to replace rock sugar; But, since the kind difference of sweeting agent, different areas crowd's mouthfeel difference, the different ages object is also different, and the quantity that therefore adds sweeting agent will be determined according to different demands.
Embodiment 2: the production of finished product donkey-hide gelatin wine.
The embodiment of the invention 2 selected donkey-hide gelatin, wolfberry fruit, its quality of the Radix Astragali meet the requirement of quality under each kind item of Chinese Pharmacopoeia 95 editions (an one), and glossy ganoderma should meet Ministry of Health's ministerial standard nineteen ninety version Chinese Pharmacopoeia about the relevant requirements under second appendix glossy ganoderma of Chinese traditional patent formulation medicine preparation item.The selected grain wine of the embodiment of the invention 2, the relevant requirements that rock sugar should meet GB2757-81 and GBn242-84 national Specification respectively.
The production method of the donkey-hide gelatin wine of the embodiment of the invention 2 as shown in Figure 1, comprises the steps:
Step 1, raw material donkey-hide gelatin piece is ground into fritter; The bulk donkey-hide gelatin of raw material is convenient to storage and transportation, but is unfavorable for the donkey-hide gelatin fusing, therefore need pulverize earlier.If the donkey-hide gelatin that directly adopts fritter as raw material, can save this step.
Step 2, the fritter donkey-hide gelatin that step 1 is obtained, by the weight ratio of donkey-hide gelatin and water be add water at 1: 3 after, again entire container is added low-grade fever to donkey-hide gelatin piece and all melts, become liquid donkey-hide gelatin liquid.Donkey-hide gelatin after the molten can add in the wine liquid easily, and can reduce the step and the intensity of stirring required when mixing.
Step 3, step 2 is obtained melting back donkey-hide gelatin liquid fully stir down and join in the wine liquid, adding donkey-hide gelatin 60-150g in 10L wine obtains the donkey-hide gelatin wine of first product.
The first product donkey-hide gelatin wine that obtains by above-mentioned steps by combining of drinks and donkey-hide gelatin, has solved the difficult problem that donkey-hide gelatin is taken inconvenience, has tentatively finished purpose of the present invention.
Because contained ganoderan and organic germanium, the contained wolfberry fruit polysaccharide of wolfberry fruit in the glossy ganoderma, the contained astragalus polysaccharides of the Radix Astragali all has the effect that strengthens body immune function, for the effect of the adjusting body immunity that increases donkey-hide gelatin wine, the embodiment of the invention 2 has adopted the grain wine that soaks glossy ganoderma, wolfberry fruit and the Radix Astragali as producing the donkey-hide gelatin liquor raw material.
As shown in Figure 1, at first, select 65 ° the grain wine of storing more than a year for use, as standby wine liquid; With glossy ganoderma 50-200g, wolfberry fruit 200-600g, Radix Astragali 200-600g clean the oven dry back and suitably pulverize, and are loaded in the diafiltration tube then.Most of raw material Chinese medicine sanitary conditions are more bad, and volume is not of uniform size, is unfavorable for extracting effective constituent wherein, so must wash earlier oven dry and pulverizing to raw material Chinese medicine.If the satisfactory finished product Chinese medicine of process above-mentioned steps can save this step but adopt.
In above-mentioned diafiltration tube, add 6 times to the standby wine liquid of the glossy ganoderma of being soaked, wolfberry fruit and Radix Astragali gross weight, seal, 25-30 ℃ was soaked 48-96 hour, after pressing percolation process collection wine liquid, add 4 times of standby wine liquid again to the glossy ganoderma of being soaked, wolfberry fruit and Radix Astragali gross weight, the same terms soaked 32-56 hour, after same procedure is collected wine liquid, squeezed residual wine liquid in the clean medicine.Merge wine liquid twice, just can be used as the wine liquid of waiting to add donkey-hide gelatin in the step 3.
As shown in Figure 1, in order to increase the mouthfeel of wine, the embodiment of the invention 2 has added rock sugar solution when adding donkey-hide gelatin liquid in wine liquid.After the suitable pulverizing of rock sugar 200-600g, add 3 times to the water of rock sugar weight, add low-grade fever and make it finish dissolving.Under fully stirring, in waiting to add the wine liquid of donkey-hide gelatin, add donkey-hide gelatin liquid and rock sugar solution, and adding an amount of standby wine liquid, to make cumulative volume be 10L.
The adding rock sugar can increase the mouthfeel of wine, makes the donkey-hide gelatin wine of being produced be more suitable for drinking.For some diabetics, therefore unable to drink, adopts sweeting agent to replace rock sugar with the beverage that contains sugar, so neither influences mouthfeel, can be suitable for the diabetics again.But, since the kind difference of sweeting agent, different areas crowd's mouthfeel difference, the different ages object is also different, and the quantity that therefore adds sweeting agent will be determined flexibly according to different demands.
For sedimentation solids and increase mouthfeel, the mixed wine liquid that obtains is carried out the cold storage of low temperature at-4 ℃-0 ℃, the time is about 48-96 hour.Tentatively finish the separation of solids in the wine liquid.At this moment solids mainly comprises: the insoluble residue in the donkey-hide gelatin and the Chinese medicine dregs of a decoction of immersion.
For the donkey-hide gelatin wine that makes production is suitable for drinking, increase the texture of wine simultaneously, also need wine liquid is filtered, further remove the solid residue in the wine liquid.
At last, the wine liquid can that obtains in bottle, has just been obtained the finished product donkey-hide gelatin wine that can directly sell on market.
In order to prove that donkey-hide gelatin drinking utensils of the present invention has the effect of regulating the human immunologic function, donkey-hide gelatin wine of the present invention has carried out the immunoregulation effect detection in Chinese Academy Of Preventive Medicine Research Institute Of Nutrition And Food Hygiene.
Embodiment 3: the donkey-hide gelatin wine that Chinese Academy Of Preventive Medicine Research Institute Of Nutrition And Food Hygiene produces the inventive method of censorship, according to sanitary inspection department of the Ministry of Health " the protective foods function assessment assessment process and the method for inspection ", the immunoregulation effect project is detected.
Experimental result is as follows:
Table 1 donkey-hide gelatin wine is to the influence of the tardy transformation reactions of mouse (DTH) (X ± SD)
| Group | Number of animals (only) | Swelling degree of the paw (mm) | The P value |
| Dosage high dosage in the contrast low dosage | 10 10 10 10 | 0.349±0.081 0.361±0.062 0.432±0.047 0.438±0.039 | ＞0.05 ＜0.01 ＜0.01 |
By table 1 as seen, the donkey-hide gelatin that per os gives various dose after drinking, middle and high dosage group mouse DTH reaction and control group relatively have extremely significant difference.The P value is that experimental data carries out obtaining after the statistical study through the t check in the last table.
Table 2 donkey-hide gelatin wine is to the influence (X ÷ SD) of splenocyte IgM-PFC
| Group | Number of mice (only) | The full spleen of IgM-PFC/ (mg) | IgM-PFC/ spleen (mg) |
| The contrast low dosage | 10 10 | 10,304÷1.183 12,274÷1.117 | 99.77÷1.225 105.4÷1.172 |
| Middle dosage high dosage | 10 10 | 15,631÷1.340 15,996÷1.387 | 128.2÷1.315* 93.33÷1.644* |
*P＜0.05
By table 1 as seen, the donkey-hide gelatin that per os gives various dose after drinking, the middle and high full spleen of dosage group mouse IgM-PFC/ (mg) IgM-PFC/ spleen (mg) and control group relatively have extremely significant difference.The P value is that experimental data carries out obtaining after the statistical study through the t check in the last table.
Assay shows that the donkey-hide gelatin drinking utensils has stronger adjusting mouse cell immunologic function to close the effect of regulating the mouse humoral immune function.
It should be noted last that: above embodiment is the unrestricted technical scheme of the present invention in order to explanation only, although the present invention is had been described in detail with reference to the foregoing description, those of ordinary skill in the art is to be understood that: still can make amendment or be equal to replacement the present invention, and not breaking away from any modification or partial replacement of the spirit and scope of the present invention, it all should be encompassed in the middle of the claim scope of the present invention.
Claims (7)
1, a kind of production method of donkey-hide gelatin wine is characterized in that: comprise the steps:
Step 1, raw material donkey-hide gelatin piece is ground into fritter;
After step 2, the fritter donkey-hide gelatin that step 1 is obtained add water, again entire container is added low-grade fever to donkey-hide gelatin piece and all melt, become liquid donkey-hide gelatin liquid;
Step 3, step 2 is obtained melting back donkey-hide gelatin liquid join in the wine liquid, add donkey-hide gelatin 60-150g in every 10L wine, obtain donkey-hide gelatin wine.
2, the production method of donkey-hide gelatin wine according to claim 1, it is characterized in that: the wine liquid in the described step 3 is the medicinal liquor that soaks glossy ganoderma, wolfberry fruit, the Radix Astragali or its combination through one or many, add glossy ganoderma 50-200g in every 10L grain wine, and/or wolfberry fruit 200-600g, and/or Radix Astragali 200-600g; Under 20-35 ℃ of condition, sealing was soaked 36-120 hour.
3, the production method of donkey-hide gelatin wine according to claim 1 and 2 is characterized in that: add sweeting agent in the wine liquid in the described step 3.
4, the production method of donkey-hide gelatin wine according to claim 3, wherein said sweeting agent are the rock sugar solution that dissolves, and add rock sugar 200-600g in every 10L wine.
5, the production method of donkey-hide gelatin wine according to claim 1 and 2 is characterized in that: also comprise after the described step 3:
Step 4, the mixed wine liquid that step 3 is obtained carry out the cold storage of low temperature at-4 ℃-0 ℃.
6, the production method of donkey-hide gelatin wine according to claim 5 is characterized in that: also comprise after the described step 4:
Step 5, the mixed wine liquid that step 4 is obtained filter, and remove the solid residue in the wine liquid.
7, the production method of donkey-hide gelatin wine according to claim 6 is characterized in that: also comprise after the described step 5:
Step 6, the mixed wine liquid that step 5 is obtained carry out can, obtain finished product donkey-hide gelatin wine.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB031568149A CN100335607C (en) | 2003-09-08 | 2003-09-08 | Donkey-hid gelatin wine and production process thereof |
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| CNB031568149A CN100335607C (en) | 2003-09-08 | 2003-09-08 | Donkey-hid gelatin wine and production process thereof |
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| CN1594532A CN1594532A (en) | 2005-03-16 |
| CN100335607C true CN100335607C (en) | 2007-09-05 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100582214C (en) * | 2007-01-05 | 2010-01-20 | 浙江省医学科学院 | Donkey-hide gelatin polypeptide wine and production process thereof |
| CN101991110B (en) * | 2010-10-11 | 2012-10-03 | 李清林 | Wild ganoderma lucidum food |
| CN109504592A (en) * | 2018-12-05 | 2019-03-22 | 海南韵华中草药开发有限公司 | A kind of glossy ganoderma ointment wine and preparation method thereof |
| CN110358656A (en) * | 2019-07-15 | 2019-10-22 | 山东福地龙泉酒业有限公司 | A kind of preparation method of donkey-hid gelatin wine |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1167638A (en) * | 1997-06-05 | 1997-12-17 | 廖开福 | Liquor for strengthening Yang |
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2003
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1167638A (en) * | 1997-06-05 | 1997-12-17 | 廖开福 | Liquor for strengthening Yang |
Non-Patent Citations (4)
| Title |
|---|
| 药酒集锦 李亮，药膳食料 2002 * |
| 药酒集锦 李亮，药膳食疗 2006 * |
| 阿胶酒的药效与毒性作用研究 刘国华，山东医药工业，第14卷第4期 1995 * |
| 阿胶酒的药效与毒性作用研究 刘国华等，山东医药工业，第14卷第4期 1995 * |
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