CL2023002632A1 - Derivados de 3h,4h-tieno [2,3-d]pirimidin-4-ona como inhibidores de trpa1 - Google Patents
Derivados de 3h,4h-tieno [2,3-d]pirimidin-4-ona como inhibidores de trpa1Info
- Publication number
- CL2023002632A1 CL2023002632A1 CL2023002632A CL2023002632A CL2023002632A1 CL 2023002632 A1 CL2023002632 A1 CL 2023002632A1 CL 2023002632 A CL2023002632 A CL 2023002632A CL 2023002632 A CL2023002632 A CL 2023002632A CL 2023002632 A1 CL2023002632 A1 CL 2023002632A1
- Authority
- CL
- Chile
- Prior art keywords
- thieno
- pyrimidin
- derivatives
- trpa1
- trpa1 inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- JEDVKUHCDPPWNR-UHFFFAOYSA-N 3h-thieno[2,3-d]pyrimidin-4-one Chemical class O=C1NC=NC2=C1C=CS2 JEDVKUHCDPPWNR-UHFFFAOYSA-N 0.000 title 1
- 101100482465 Caenorhabditis elegans trpa-1 gene Proteins 0.000 title 1
- DNCYBUMDUBHIJZ-UHFFFAOYSA-N 1h-pyrimidin-6-one Chemical class O=C1C=CN=CN1 DNCYBUMDUBHIJZ-UHFFFAOYSA-N 0.000 abstract 1
- 102100031366 Ankyrin-1 Human genes 0.000 abstract 1
- 101710191059 Ankyrin-1 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001052 transient effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente divulgación proporciona algunos derivados de 3H,4H-tieno 2,3-d pirimidin-4-ona que son inhibidores del potencial de receptor transitorio anquirina 1 (TRPA1), y son por lo tanto útiles para el tratamiento de enfermedades que se pueden tratar mediante inhibición de TRPA1. Asimismo, se proporcionan composiciones farmacéuticas que los contienen, y procesos para la preparación de dichos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21168436 | 2021-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2023002632A1 true CL2023002632A1 (es) | 2024-03-15 |
Family
ID=75539077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2023002632A CL2023002632A1 (es) | 2021-04-14 | 2023-09-05 | Derivados de 3h,4h-tieno [2,3-d]pirimidin-4-ona como inhibidores de trpa1 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20220340590A1 (es) |
| EP (1) | EP4323367A1 (es) |
| JP (1) | JP2024511481A (es) |
| KR (1) | KR20230170932A (es) |
| CN (1) | CN117222652A (es) |
| AU (1) | AU2022257269A1 (es) |
| BR (1) | BR112023015342A2 (es) |
| CA (1) | CA3210965A1 (es) |
| CL (1) | CL2023002632A1 (es) |
| IL (1) | IL306083A (es) |
| TW (1) | TW202309046A (es) |
| WO (1) | WO2022219014A1 (es) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017060488A1 (en) | 2015-10-09 | 2017-04-13 | Almirall, S.A. | New trpa1 antagonists |
-
2022
- 2022-04-13 BR BR112023015342A patent/BR112023015342A2/pt unknown
- 2022-04-13 CA CA3210965A patent/CA3210965A1/en active Pending
- 2022-04-13 TW TW111113971A patent/TW202309046A/zh unknown
- 2022-04-13 KR KR1020237038466A patent/KR20230170932A/ko unknown
- 2022-04-13 WO PCT/EP2022/059817 patent/WO2022219014A1/en active Application Filing
- 2022-04-13 JP JP2023559023A patent/JP2024511481A/ja active Pending
- 2022-04-13 IL IL306083A patent/IL306083A/en unknown
- 2022-04-13 US US17/719,432 patent/US20220340590A1/en active Pending
- 2022-04-13 EP EP22722509.1A patent/EP4323367A1/en active Pending
- 2022-04-13 AU AU2022257269A patent/AU2022257269A1/en active Pending
- 2022-04-13 CN CN202280025646.8A patent/CN117222652A/zh active Pending
-
2023
- 2023-09-05 CL CL2023002632A patent/CL2023002632A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112023015342A2 (pt) | 2023-11-07 |
| JP2024511481A (ja) | 2024-03-13 |
| EP4323367A1 (en) | 2024-02-21 |
| US20220340590A1 (en) | 2022-10-27 |
| KR20230170932A (ko) | 2023-12-19 |
| AU2022257269A1 (en) | 2023-08-17 |
| IL306083A (en) | 2023-11-01 |
| CN117222652A (zh) | 2023-12-12 |
| CA3210965A1 (en) | 2022-10-20 |
| TW202309046A (zh) | 2023-03-01 |
| WO2022219014A1 (en) | 2022-10-20 |
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