CL2022000111A1 - Derivados de n-(6-metoxi)pirizadin-3-il) amina, n-metilo como moduladores de autotaxina (atx) para el tratamiento de enfermedades inflamatorias de las vías respiratorias o fibróticas - Google Patents

Derivados de n-(6-metoxi)pirizadin-3-il) amina, n-metilo como moduladores de autotaxina (atx) para el tratamiento de enfermedades inflamatorias de las vías respiratorias o fibróticas

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Publication number
CL2022000111A1
CL2022000111A1 CL2022000111A CL2022000111A CL2022000111A1 CL 2022000111 A1 CL2022000111 A1 CL 2022000111A1 CL 2022000111 A CL2022000111 A CL 2022000111A CL 2022000111 A CL2022000111 A CL 2022000111A CL 2022000111 A1 CL2022000111 A1 CL 2022000111A1
Authority
CL
Chile
Prior art keywords
methoxy
pyrizadin
autotaxin
atx
modulators
Prior art date
Application number
CL2022000111A
Other languages
English (en)
Inventor
Cédrickx Godbout
Christian Andreas Kuttruff
Hannes Fiepko Koolman
Gerald Juergen Roth
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2022000111A1 publication Critical patent/CL2022000111A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a derivados de N-(6-metoxi)pirizadin-3-il) amina, Nmetilo como moduladores de autotaxina (ATX) para el tratamiento de enfermedades inflamatorias de las vías respiratorias y fibróticas tales como, por ejemplo, enfermedad pulmonar idiopática (IFF), o esclerosis sistémica (SSc). La presente descripción divulga la preparación de compuestos de ejemplo (por ejemplo, páginas 37 a 45; ejemplos 1.1 a 1.13) así como información biológica relevante (por ejemplo, páginas 12 a 17, tablas 1 a 9). Un compuesto de ejemplo es, por ejemplo, 1-[4-(4-{1-[{6-{[6-(trifluorometil)piridin-3- il]metoxi}piridazin-3-il)amino]ciclopropil}-fenil)piperazin-1-il]etan-]-1-ona (ejemplo 1.1).
CL2022000111A 2019-07-22 2022-01-17 Derivados de n-(6-metoxi)pirizadin-3-il) amina, n-metilo como moduladores de autotaxina (atx) para el tratamiento de enfermedades inflamatorias de las vías respiratorias o fibróticas CL2022000111A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19187616 2019-07-22

Publications (1)

Publication Number Publication Date
CL2022000111A1 true CL2022000111A1 (es) 2022-10-21

Family

ID=67438401

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2022000111A CL2022000111A1 (es) 2019-07-22 2022-01-17 Derivados de n-(6-metoxi)pirizadin-3-il) amina, n-metilo como moduladores de autotaxina (atx) para el tratamiento de enfermedades inflamatorias de las vías respiratorias o fibróticas

Country Status (12)

Country Link
US (1) US20220281838A1 (es)
EP (1) EP4003978B1 (es)
JP (1) JP7240554B2 (es)
KR (1) KR20220035950A (es)
CN (1) CN114127054B (es)
AU (1) AU2020318697A1 (es)
BR (1) BR112021026267A2 (es)
CA (1) CA3145960A1 (es)
CL (1) CL2022000111A1 (es)
IL (1) IL289800A (es)
MX (1) MX2022000955A (es)
WO (1) WO2021013833A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7214860B2 (ja) 2018-10-29 2023-01-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規なピリダジン
US11465982B2 (en) 2019-07-22 2022-10-11 Boehringer Ingelheim International Gmbh Pyridazines
US11485727B2 (en) 2019-07-22 2022-11-01 Boehringer Ingelheim International Gmbh N-methyl, n-(6-(methoxy)pyridazin-3-yl) amine derivatives as autotaxin (ATX) modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9273011B2 (en) * 2011-10-28 2016-03-01 Inhibitaxin Limited Substituted pyridazines for the treatment of pain
JP6339595B2 (ja) * 2013-03-14 2018-06-06 ガラパゴス・ナムローゼ・フェンノートシャップＧａｌａｐａｇｏｓ Ｎ．Ｖ． 炎症性障害の治療のための化合物及びその医薬組成物
WO2014179144A1 (en) * 2013-04-29 2014-11-06 E. I. Du Pont De Nemours And Company Fungicidal heterocyclic compounds
WO2014202458A1 (en) * 2013-06-19 2014-12-24 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders
JP7214860B2 (ja) * 2018-10-29 2023-01-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規なピリダジン

Also Published As

Publication number Publication date
AU2020318697A1 (en) 2022-01-27
EP4003978B1 (en) 2024-05-01
EP4003978A1 (en) 2022-06-01
BR112021026267A2 (pt) 2022-05-31
CA3145960A1 (en) 2021-01-28
JP7240554B2 (ja) 2023-03-15
CN114127054A (zh) 2022-03-01
CN114127054B (zh) 2024-04-09
KR20220035950A (ko) 2022-03-22
IL289800A (en) 2022-03-01
MX2022000955A (es) 2022-02-14
JP2022541613A (ja) 2022-09-26
WO2021013833A1 (en) 2021-01-28
US20220281838A1 (en) 2022-09-08

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