MX2019008626A - Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-ilcarbamato como inhibidores de monoacilglicerol lipasa (magl). - Google Patents

Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-ilcarbamato como inhibidores de monoacilglicerol lipasa (magl).

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Publication number
MX2019008626A
MX2019008626A MX2019008626A MX2019008626A MX2019008626A MX 2019008626 A MX2019008626 A MX 2019008626A MX 2019008626 A MX2019008626 A MX 2019008626A MX 2019008626 A MX2019008626 A MX 2019008626A MX 2019008626 A MX2019008626 A MX 2019008626A
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MX
Mexico
Prior art keywords
hydroxypropan
trifluoro
carbamate derivatives
magl inhibitors
compounds
Prior art date
Application number
MX2019008626A
Other languages
English (en)
Inventor
Victor O'neil Steven
Aaron Brodney Michael
Ryan Butler Christopher
John Helal Christopher
Robert Verhoest Patrick
Ann Mcallister Laura
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2019008626A publication Critical patent/MX2019008626A/es

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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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Abstract

La presente invencion proporciona, en parte, compuestos de la Formula I: (ver fórmula) y sales farmaceuticamente aceptables de los mismos; procesos para la preparacion de; intermediarios utilizados en la preparacion de; y composiciones que contienen tales compuestos o sales, y sus usos para tratar enfermedades y trastornos mediados por MAGL incluyendo, por ejemplo, dolor, un trastorno inflamatorio, depresion, ansiedad, enfermedad de Alzheimer, un trastorno metabolico, derrame cerebral, o cancer.
MX2019008626A 2017-01-20 2018-01-08 Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-ilcarbamato como inhibidores de monoacilglicerol lipasa (magl). MX2019008626A (es)

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