CL2021002769A1 - Anticuerpos de unión a vista (divisional solicitud n° 201902610) - Google Patents

Anticuerpos de unión a vista (divisional solicitud n° 201902610)

Info

Publication number
CL2021002769A1
CL2021002769A1 CL2021002769A CL2021002769A CL2021002769A1 CL 2021002769 A1 CL2021002769 A1 CL 2021002769A1 CL 2021002769 A CL2021002769 A CL 2021002769A CL 2021002769 A CL2021002769 A CL 2021002769A CL 2021002769 A1 CL2021002769 A1 CL 2021002769A1
Authority
CL
Chile
Prior art keywords
sight
divisional application
binding antibodies
antibodies
acidic
Prior art date
Application number
CL2021002769A
Other languages
English (en)
Inventor
Robert J Johnston
Arvind Rajpal
Paul O Sheppard
Luis Borges
Andrew Rankin
Keith Sadoon Bahjat
Alan J Korman
lin hui Su
Ginger RAKESTRAW
Andy X Deng
Original Assignee
Five Prime Therapeutics Inc
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Five Prime Therapeutics Inc, Bristol Myers Squibb Co filed Critical Five Prime Therapeutics Inc
Publication of CL2021002769A1 publication Critical patent/CL2021002769A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

La presente solicitud se relaciona con anticuerpos que se unen específicamente al supresor de la activación de células T que contiene el dominio V de inmunoglobulina d(VISTA) a pH ácido y su uso en el tratamiento del cáncer. En algunas modalidades, los anticuerpos se unen específicamente a VISTA humano a pH ácido, pero no se unen significativamente a VISTA humano a pH neutro o fisiológico.
CL2021002769A 2017-03-14 2021-10-21 Anticuerpos de unión a vista (divisional solicitud n° 201902610) CL2021002769A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762471196P 2017-03-14 2017-03-14
US201862636746P 2018-02-28 2018-02-28

Publications (1)

Publication Number Publication Date
CL2021002769A1 true CL2021002769A1 (es) 2022-08-12

Family

ID=63522565

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2019002610A CL2019002610A1 (es) 2017-03-14 2019-09-12 Anticuerpos de unión a vista a ph ácido.
CL2021002769A CL2021002769A1 (es) 2017-03-14 2021-10-21 Anticuerpos de unión a vista (divisional solicitud n° 201902610)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CL2019002610A CL2019002610A1 (es) 2017-03-14 2019-09-12 Anticuerpos de unión a vista a ph ácido.

Country Status (16)

Country Link
US (2) US11603406B2 (es)
EP (1) EP3595720A4 (es)
JP (2) JP7211961B2 (es)
KR (1) KR20190128198A (es)
CN (1) CN110740749A (es)
AU (1) AU2018236218A1 (es)
BR (1) BR112019019108A2 (es)
CA (1) CA3054067A1 (es)
CL (2) CL2019002610A1 (es)
CO (1) CO2019010943A2 (es)
IL (1) IL269240A (es)
MY (1) MY200609A (es)
PE (1) PE20191708A1 (es)
SG (1) SG11201907848YA (es)
TW (1) TWI825010B (es)
WO (1) WO2018169993A1 (es)

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Also Published As

Publication number Publication date
CL2019002610A1 (es) 2019-11-29
AU2018236218A1 (en) 2019-09-12
US20200055936A1 (en) 2020-02-20
US20240092907A1 (en) 2024-03-21
TWI825010B (zh) 2023-12-11
TW201843171A (zh) 2018-12-16
EP3595720A4 (en) 2021-05-26
CA3054067A1 (en) 2018-09-20
BR112019019108A2 (pt) 2020-04-22
JP2023061927A (ja) 2023-05-02
IL269240A (en) 2019-11-28
US11603406B2 (en) 2023-03-14
KR20190128198A (ko) 2019-11-15
JP2020509756A (ja) 2020-04-02
SG11201907848YA (en) 2019-09-27
MY200609A (en) 2024-01-05
WO2018169993A1 (en) 2018-09-20
CN110740749A (zh) 2020-01-31
CO2019010943A2 (es) 2020-01-17
PE20191708A1 (es) 2019-11-28
JP7211961B2 (ja) 2023-01-24
EP3595720A1 (en) 2020-01-22

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