CL2021002267A1 - Métodos para tratar cánceres y potenciar la eficacia de agentes terapéuticos para el redireccionamiento de células t. (divisional de solicitud 202002945) - Google Patents

Métodos para tratar cánceres y potenciar la eficacia de agentes terapéuticos para el redireccionamiento de células t. (divisional de solicitud 202002945)

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Publication number
CL2021002267A1
CL2021002267A1 CL2021002267A CL2021002267A CL2021002267A1 CL 2021002267 A1 CL2021002267 A1 CL 2021002267A1 CL 2021002267 A CL2021002267 A CL 2021002267A CL 2021002267 A CL2021002267 A CL 2021002267A CL 2021002267 A1 CL2021002267 A1 CL 2021002267A1
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CL
Chile
Prior art keywords
subject
antibody
efficacy
enhancing
methods
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CL2021002267A
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English (en)
Inventor
Francois Gaudet
Homer Adams
De Donk Niels Van
Christie C P M Verleij
Kris Frerichs
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Janssen Biotech Inc
Stichting Vumc
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Application filed by Janssen Biotech Inc, Stichting Vumc filed Critical Janssen Biotech Inc
Publication of CL2021002267A1 publication Critical patent/CL2021002267A1/es

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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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Abstract

La descripción proporciona métodos para tratar un cáncer y/o destruir células tumorales en un sujeto, que comprende administrar una cantidad terapéuticamente eficaz de un anticuerpo anti-CD38 y un agente terapéutico para el redireccionamiento de células T al sujeto para tratar el cáncer. La presente descripción proporciona un método para potenciar la eficacia de un agente terapéutico para el redireccionamiento de células T en un sujeto que tiene un cáncer, que comprende administrar al sujeto un anticuerpo anti-CD38. La descripción también proporciona un método para tratar un mieloma múltiple en un sujeto, que comprende administrar una cantidad terapéuticamente eficaz de un anticuerpo biespecífico BCMAxCDS y un anticuerpo anti-CD38 al sujeto para tratar el mieloma múltiple. La descripción también proporciona una combinación farmacéutica que comprende un anticuerpo biespecífico GPRC5DxCD3. La descripción también proporciona un kit que comprende una composición farmacéutica que comprende un anticuerpo biespecífico BCMAxCD3 y un anticuerpo anti-CD38.
CL2021002267A 2018-05-16 2021-08-27 Métodos para tratar cánceres y potenciar la eficacia de agentes terapéuticos para el redireccionamiento de células t. (divisional de solicitud 202002945) CL2021002267A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862672222P 2018-05-16 2018-05-16
US201862736804P 2018-09-26 2018-09-26
US201962842080P 2019-05-02 2019-05-02

Publications (1)

Publication Number Publication Date
CL2021002267A1 true CL2021002267A1 (es) 2022-04-01

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Family Applications (2)

Application Number Title Priority Date Filing Date
CL2020002945A CL2020002945A1 (es) 2018-05-16 2020-11-12 Métodos para tratar cánceres y potenciar la eficacia de agentes terapéuticos para el redireccionamiento de células t
CL2021002267A CL2021002267A1 (es) 2018-05-16 2021-08-27 Métodos para tratar cánceres y potenciar la eficacia de agentes terapéuticos para el redireccionamiento de células t. (divisional de solicitud 202002945)

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CL2020002945A CL2020002945A1 (es) 2018-05-16 2020-11-12 Métodos para tratar cánceres y potenciar la eficacia de agentes terapéuticos para el redireccionamiento de células t

Country Status (18)

Country Link
US (3) US20190352421A1 (es)
EP (2) EP3793599A1 (es)
JP (4) JP7444790B2 (es)
KR (2) KR20220080044A (es)
CN (2) CN112368019A (es)
AU (4) AU2019270623B2 (es)
BR (2) BR112020023187A2 (es)
CA (2) CA3100118A1 (es)
CL (2) CL2020002945A1 (es)
DO (1) DOP2020000209A (es)
JO (1) JOP20200292A1 (es)
MA (2) MA52632A (es)
MX (2) MX2020012270A (es)
PH (2) PH12020551908A1 (es)
SG (2) SG11202011306TA (es)
TW (2) TW202016132A (es)
UY (2) UY38236A (es)
WO (2) WO2019220369A2 (es)

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