CL2019001988A1 - Compuestos químicos como inhibidores de actividad interleuquina-2. - Google Patents

Compuestos químicos como inhibidores de actividad interleuquina-2.

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Publication number
CL2019001988A1
CL2019001988A1 CL2019001988A CL2019001988A CL2019001988A1 CL 2019001988 A1 CL2019001988 A1 CL 2019001988A1 CL 2019001988 A CL2019001988 A CL 2019001988A CL 2019001988 A CL2019001988 A CL 2019001988A CL 2019001988 A1 CL2019001988 A1 CL 2019001988A1
Authority
CL
Chile
Prior art keywords
opalis
compounds
modulation
group
substitute
Prior art date
Application number
CL2019001988A
Other languages
English (en)
Inventor
Jeffrey A Stafford
James M Veal
Christopher Mcbride
Llynnie Lin Trzoss
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Genentech Inc
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Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CL2019001988A1 publication Critical patent/CL2019001988A1/es

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Abstract

LA PRESENTE DESCRIPCIÓN PROVEE COMPUESTOS QUE SON EFICACES EN LA INHIBICIÓN DE UN INFLAMASOMA, TAL COMO EL INFLAMASOMA NLRP3. LOS COMPUESTOS TAMBIÉN SON EFICACES EN LA MODULACIÓN DE INTERLEUQUINAS. LOS COMPUESTOS DIVULGADOS TIENEN PESOS MOLECULARES, PROPIEDADES FISICOQUÍMICAS, Y LIPOFILICIDAD DESEABLES, LAS CUALES SON CARACTERÍSTICAS QUE AYUDAN A CONSEGUIR EFICACIA TERAPÉUTICA Y DISMINUIR LOS EFECTOS NO DESEADOS. LA PRESENTE INVENCIÓN PROVEE COMPUESTOS DE FÓRMULA I, Y SALES, FÁRMACOS, SOLVATOS, HIDRATOS, ISÓMEROS, O TAUTÓMEROS FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS, DONDE: R1 SE SELECCIONA ENTRE EL GRUPO QUE CONSISTE EN C1-C6ALQUILO OPCIONALMENTE SUSTITUIDO, C1- C6ALQUENILO OPCIONALMENTE SUSTITUIDO, C1-C6ALQUINILO OPCIONALMENTE SUSTITUIDO, -(CH2)M-O- (CH2)M-CH3. LA PRESENTE DESCRIPCIÓN SE RELACIONA CON COMPUESTOS NOVEDOSOS DE SULFONILUREA Y SULFONIL TIOUREA COMPUESTOS Y COMPUESTOS RELACIONADOS Y SU USO PARA TRATAR UNA ENFERMEDAD O CONDICIÓN QUE ES SENSIBLE A LA MODULACIÓN DE CITOQUINAS TALES COMO IL-1Β E IL-18, MODULACIÓN DE NLRP3 O INHIBICIÓN DE LA ACTIVACIÓN DE NLRP3 O COMPONENTES RELACIONADOS DEL PROCESO INFLAMATORIO.
CL2019001988A 2017-01-23 2019-07-15 Compuestos químicos como inhibidores de actividad interleuquina-2. CL2019001988A1 (es)

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