CL2016003048A1 - Analogos de panonina minimas sintesis y uso de los mismos. - Google Patents

Analogos de panonina minimas sintesis y uso de los mismos.

Info

Publication number
CL2016003048A1
CL2016003048A1 CL2016003048A CL2016003048A CL2016003048A1 CL 2016003048 A1 CL2016003048 A1 CL 2016003048A1 CL 2016003048 A CL2016003048 A CL 2016003048A CL 2016003048 A CL2016003048 A CL 2016003048A CL 2016003048 A1 CL2016003048 A1 CL 2016003048A1
Authority
CL
Chile
Prior art keywords
saponin
panonin
analogues
minimizes
synthesis
Prior art date
Application number
CL2016003048A
Other languages
English (en)
Inventor
David Y Gin
Eric K Chea
Alberto Fernandez-Tejada
Derek S Tan
Jason S Lewis
Jeffrey R Gardner
Nagavarakishore Pillarsetty
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Publication of CL2016003048A1 publication Critical patent/CL2016003048A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7024—Esters of saccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<p>Se describen análogos truncados de saponina triterpénica que contienen un trisacárido o éster tetrasacárido. También se describen composiciones farmacéuticas que comprenden análogos truncados de saponina y métodos sintéticos para producir la saponina truncada. Otro aspecto de la presente solicitud se refiere a un método para inmunizar un sujeto, que comprende administrar al sujeto la composición farmacéutica que comprende un análogo de saponina mínimo y un antígeno.</p>
CL2016003048A 2014-05-30 2016-11-28 Analogos de panonina minimas sintesis y uso de los mismos. CL2016003048A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462005302P 2014-05-30 2014-05-30

Publications (1)

Publication Number Publication Date
CL2016003048A1 true CL2016003048A1 (es) 2017-06-16

Family

ID=54699970

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016003048A CL2016003048A1 (es) 2014-05-30 2016-11-28 Analogos de panonina minimas sintesis y uso de los mismos.

Country Status (14)

Country Link
US (3) US10626137B2 (es)
EP (2) EP3149015B1 (es)
JP (2) JP6774943B2 (es)
KR (1) KR102424785B1 (es)
CN (2) CN106573951B (es)
AU (3) AU2015266624A1 (es)
CA (1) CA2950750C (es)
CL (1) CL2016003048A1 (es)
DK (1) DK3149015T3 (es)
ES (1) ES2887400T3 (es)
IL (3) IL290897B2 (es)
SG (2) SG10202106403QA (es)
WO (1) WO2015184451A1 (es)
ZA (3) ZA201608255B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102453184B1 (ko) * 2008-04-08 2022-10-07 슬로안-케테링인스티튜트퍼캔서리서치 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
DK3149015T3 (da) * 2014-05-30 2021-09-27 Memorial Sloan Kettering Cancer Center Minimale saponin-analoger, syntese og anvendelse deraf
CA3003483C (en) * 2015-11-06 2022-09-13 Adjuvance Technologies, Inc. Triterpene saponin analogues
ES2944947T3 (es) * 2015-12-17 2023-06-27 Memorial Sloan Kettering Cancer Center Variantes de triterpeno-saponina, métodos de síntesis y uso de las mismas
IL269963B1 (en) * 2017-04-13 2024-05-01 Adjuvance Tech Inc Synthesis of triterpene saponins, intermediates and adjuvant combinations
US20200164065A1 (en) * 2017-04-25 2020-05-28 Adjuvance Technologies, Inc. Triterpene saponin analogues
EP3697802A4 (en) 2017-10-16 2021-11-24 Adjuvance Technologies, Inc. TRITERPENIC SAPONIN ANALOGUES
WO2021014019A1 (en) * 2019-07-25 2021-01-28 Sapreme Technologies B.V. Saponin derivatives with improved therapeutic window
EP4054616A4 (en) * 2019-11-05 2024-06-26 Adjuvance Tech Inc VARICELLA-ZOSTER
AU2021295292A1 (en) 2020-06-24 2023-02-16 Sapreme Technologies B.V. Saponin derivatives for use in medicine
WO2023081505A1 (en) * 2021-11-08 2023-05-11 Adjuvance Technologies, Inc. Adjuvant compounds and formulations
EP4190359A1 (en) 2021-12-03 2023-06-07 Asociación Centro de Investigación Cooperativa en Biociencias - CIC bioGUNE Saponin-based adjuvants and vaccines
WO2023139145A1 (en) 2022-01-19 2023-07-27 Asociación Centro De Investigación Cooperativa En Biociencias-Cic Biogune Saponin-based adjuvants and vaccines
CN117244053B (zh) * 2023-10-16 2024-04-26 国药中生生物技术研究院有限公司 具有常春藤皂苷元-O-Ara结构的化合物的佐剂用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102453184B1 (ko) * 2008-04-08 2022-10-07 슬로안-케테링인스티튜트퍼캔서리서치 트리테르펜 사포닌, 그의 합성 방법, 및 그의 용도
US8883170B2 (en) * 2008-09-03 2014-11-11 Western Illinois University Research Foundation Adjuvant
CN103768078B (zh) * 2012-10-22 2019-02-05 北京大学 三萜衍生物及其抗流感用途
CN103265606B (zh) 2013-05-31 2015-04-01 徐江平 一种常春藤皂苷元酰胺衍生物及其制备方法及其应用
CN103694375B (zh) 2013-12-13 2016-10-05 北京大学 一种三萜-环糊精共价化合物及其制备方法和用途
DK3149015T3 (da) * 2014-05-30 2021-09-27 Memorial Sloan Kettering Cancer Center Minimale saponin-analoger, syntese og anvendelse deraf
CA3003483C (en) * 2015-11-06 2022-09-13 Adjuvance Technologies, Inc. Triterpene saponin analogues
EP3697802A4 (en) * 2017-10-16 2021-11-24 Adjuvance Technologies, Inc. TRITERPENIC SAPONIN ANALOGUES

Also Published As

Publication number Publication date
JP2017518374A (ja) 2017-07-06
KR102424785B1 (ko) 2022-07-25
US10626137B2 (en) 2020-04-21
IL249196A0 (en) 2017-01-31
EP3149015A1 (en) 2017-04-05
EP3149015B1 (en) 2021-07-21
AU2021245129A1 (en) 2021-11-04
JP2021006570A (ja) 2021-01-21
AU2015266624A1 (en) 2016-12-15
US20220275017A1 (en) 2022-09-01
AU2019279971B2 (en) 2021-07-15
WO2015184451A1 (en) 2015-12-03
US11274116B2 (en) 2022-03-15
EP3929202A1 (en) 2021-12-29
ES2887400T3 (es) 2021-12-22
IL290897B1 (en) 2023-06-01
IL290897A (en) 2022-04-01
CN106573951B (zh) 2020-09-11
IL276674B (en) 2022-04-01
EP3149015A4 (en) 2017-12-27
CN106573951A (zh) 2017-04-19
DK3149015T3 (da) 2021-09-27
CA2950750C (en) 2023-01-10
SG11201610004PA (en) 2016-12-29
CA2950750A1 (en) 2015-12-03
SG10202106403QA (en) 2021-07-29
ZA202003022B (en) 2023-10-25
CN112028951A (zh) 2020-12-04
US20170096444A1 (en) 2017-04-06
JP6774943B2 (ja) 2020-10-28
ZA201808005B (en) 2021-04-28
AU2019279971A1 (en) 2020-01-16
IL290897B2 (en) 2023-10-01
IL249196B (en) 2020-08-31
JP7145188B2 (ja) 2022-09-30
IL276674A (en) 2020-09-30
AU2021245129B2 (en) 2023-12-07
ZA201608255B (en) 2019-04-24
US20210070796A1 (en) 2021-03-11
KR20170032241A (ko) 2017-03-22

Similar Documents

Publication Publication Date Title
CL2016003048A1 (es) Analogos de panonina minimas sintesis y uso de los mismos.
CL2020001048A1 (es) Anticuerpos monoclonales contra bcma. (divisional solicitud 201800281)
CL2018000829A1 (es) Anticuerpos anti-cd19 humano con alta afinidad
CO2017012786A2 (es) Nuevos derivados hidroxiéster, un proceso para su preparación y composiciones farmacéuticas que los contienen
ECSP18014922A (es) Composiciones de insulina de rápida acción
BR112013022397A2 (pt) vacinas combinadas com doses menores de antígeno e/ou adjuvante
CR20140431A (es) Anticuerpos biespecificos contra tweak humana e il 17 humana y usos de los mismos
GT201300186A (es) Composiciones farmacéuticas que comprenden anticuerpos humanos frente a pcsk9
CO2018003452A2 (es) Anticuerpos biespecíficos contra el cd20 humano y el receptor de transferrina humano y métodos de uso
GT201400297A (es) Nuevos derivados tienopirimidina, un proceso para su preparación y composiciones farmacéuticas que los contienen
TR201908003T4 (tr) TLR4 agonistleri içeren gelişmiş adjuvan formülasyonları ve bunların kullanım metotları.
CR20150228A (es) Inhibidores de la tirosina-quinasa de bruton
CL2020000632A1 (es) Composición y método para el tratamiento del autismo.
DOP2015000270A (es) Potenciador de inhibidores del homólogo de zeste
UY36224A (es) Compuestos tricíclicos de imidazo-pirimidinona
CL2020000879A1 (es) Análogos de saponina de triterpeno.
SV2016005153A (es) Compuestos y composiciones como inhibidores de la mek
ECSP17057131A (es) Desacetoxitubulisina h y análogos de esta
CO2020007018A2 (es) Proceso para preparar tapinarof
UY35276A (es) Nuevos compuestos que inhiben la actividad de Lp-PLA2
CO2017009130A2 (es) Métodos para preparar buprenorfina
CL2019003064A1 (es) Análogos de triterperno saponina.
BR112017008952A2 (pt) métodos e composições para vírus recombinantes da dengue para desenvolvimento de vacina e diagnóstico
BR112015032388A2 (pt) métodos e composições para as vacinas contra o vírus da dengue
CL2021002149A1 (es) Formulación de afabicin, método para elaborar la misma