CL2016001760A1 - Adc de duocarmicina que demuestran mayor actividad antitumoral in vivo. - Google Patents
Adc de duocarmicina que demuestran mayor actividad antitumoral in vivo.Info
- Publication number
- CL2016001760A1 CL2016001760A1 CL2016001760A CL2016001760A CL2016001760A1 CL 2016001760 A1 CL2016001760 A1 CL 2016001760A1 CL 2016001760 A CL2016001760 A CL 2016001760A CL 2016001760 A CL2016001760 A CL 2016001760A CL 2016001760 A1 CL2016001760 A1 CL 2016001760A1
- Authority
- CL
- Chile
- Prior art keywords
- adc
- vivo
- duocarmycin
- antitumor activity
- demonstrating increased
- Prior art date
Links
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 title abstract 2
- 229960005501 duocarmycin Drugs 0.000 title abstract 2
- 229930184221 duocarmycin Natural products 0.000 title abstract 2
- 238000001727 in vivo Methods 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 239000000611 antibody drug conjugate Substances 0.000 abstract 2
- 229940049595 antibody-drug conjugate Drugs 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 1
Classifications
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Abstract
<p>CONJUGADOS ANTICUERPO-FÁRMACO (ADC) QUE CONTIENEN DUOCARMICINA Y QUE DEMUESTRAN MAYOR ACTIVIDAD ANTITUMORAL IN VIVO.</p>
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EP14150791 | 2014-01-10 | ||
EP14188450 | 2014-10-10 |
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CL2016001760A CL2016001760A1 (es) | 2014-01-10 | 2016-07-08 | Adc de duocarmicina que demuestran mayor actividad antitumoral in vivo. |
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CN (1) | CN105899236B (es) |
AU (2) | AU2015205509B2 (es) |
BR (1) | BR112016015848A2 (es) |
CA (1) | CA2935433C (es) |
CL (1) | CL2016001760A1 (es) |
CY (2) | CY1117687T1 (es) |
DK (2) | DK3069735T3 (es) |
ES (2) | ES2668984T3 (es) |
HR (2) | HRP20160697T1 (es) |
HU (2) | HUE037250T2 (es) |
LT (1) | LT3069735T (es) |
MX (2) | MX368396B (es) |
NO (1) | NO3069735T3 (es) |
PL (2) | PL2948184T3 (es) |
PT (2) | PT2948184T (es) |
RU (2) | RU2769700C2 (es) |
SG (2) | SG11201605602XA (es) |
WO (1) | WO2015104385A2 (es) |
ZA (2) | ZA201604535B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
PT2344478T (pt) | 2008-11-03 | 2017-11-28 | Syntarga Bv | Análogos de cc-1065 e seus conjugados |
DK3056203T3 (da) | 2010-04-21 | 2018-01-29 | Syntarga Bv | Konjugater af cc-1065-analoger og bifunktionelle linkere. |
SG10201705150RA (en) | 2012-12-21 | 2017-07-28 | Bioalliance Cv | Hydrophilic self-immolative linkers and conjugates thereof |
SG11201605597VA (en) | 2014-01-10 | 2016-08-30 | Synthon Biopharmaceuticals Bv | Duocarmycin adcs for use in treatment of endometrial cancer |
CN105899236B (zh) | 2014-01-10 | 2019-07-26 | 斯索恩生物制药有限公司 | 表现出改进的体内抗肿瘤活性的倍癌霉素adc |
PL3092010T3 (pl) | 2014-01-10 | 2019-01-31 | Synthon Biopharmaceuticals B.V. | Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek |
SG10201913977TA (en) | 2014-05-22 | 2020-03-30 | Synthon Biopharmaceuticals Bv | Site-specific conjugation of linker drugs to antibodies and resulting adcs |
TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
WO2015195925A1 (en) | 2014-06-18 | 2015-12-23 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates and methods of using same |
RU2017101331A (ru) * | 2014-06-20 | 2018-07-23 | Абгеномикс Интернэшнл Инк. | Конъюгаты антитело к her2 - лекарственное средство |
CN106661124A (zh) | 2014-06-20 | 2017-05-10 | 荷商台医(有限合伙)公司 | 抗叶酸受体α(FRA)抗体‑药物缀合物及其使用方法 |
LT3319597T (lt) | 2015-07-10 | 2021-07-26 | Byondis B.V. | Kompozicijos apimančios antikūno-vaisto duokarmicino konjugatus |
US10821191B2 (en) * | 2015-09-22 | 2020-11-03 | Byondis B.V. | SYD985 treatment of T-DM1 refractory cancer patients |
CN106729743B (zh) | 2015-11-23 | 2021-09-21 | 四川科伦博泰生物医药股份有限公司 | 抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用 |
ES2970186T3 (es) * | 2015-11-25 | 2024-05-27 | Immunogen Inc | Formulaciones farmacéuticas y métodos de uso de las mismas |
US10472422B2 (en) | 2016-01-08 | 2019-11-12 | Abgenomics International Inc. | Tetravalent anti-PSGL-1 antibodies and uses thereof |
JP7002467B2 (ja) | 2016-04-15 | 2022-01-20 | マクロジェニクス,インコーポレーテッド | 新規のb7‐h3結合分子、その抗体薬物コンジュゲート、及びその使用方法 |
GB201708909D0 (en) * | 2017-06-05 | 2017-07-19 | Orthox Ltd | Implantable tissue repair devices and methods for manufacturing the same |
US20210369705A1 (en) | 2018-10-15 | 2021-12-02 | Merck Patent Gmbh | Combination therapy utilizing dna alkylating agents and atr inhibitors |
CN112969478B (zh) * | 2018-11-09 | 2023-10-27 | 拜奥迪斯私人有限公司 | 可滤过的含倍癌霉素抗体-药物缀合物组合物及相关方法 |
MX2022009696A (es) * | 2020-02-06 | 2022-09-07 | Byondis Bv | Combinacion que contiene un conjugado de anticuerpo-farmaco que comprende derivado de duocarmicina y tiosulfato. |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1238907A (en) | 1984-02-21 | 1988-07-05 | Robert C. Kelly | 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds |
US4771128A (en) | 1986-10-10 | 1988-09-13 | Cetus Corporation | Method of purifying toxin conjugates using hydrophobic interaction chromatography |
MX9203460A (es) | 1988-09-12 | 1992-09-01 | Upjohn Co | Nuevos analogos cc-1065 que tienen dos subunidades cpi. |
KR100208957B1 (ko) | 1990-04-25 | 1999-07-15 | 로렌스 티. 마이젠헬더 | 신규한 cc-1065 유사체 |
JPH05268205A (ja) | 1992-03-19 | 1993-10-15 | Fujitsu Ltd | クロック切換え回路 |
EP0563475B1 (en) | 1992-03-25 | 2000-05-31 | Immunogen Inc | Cell binding agent conjugates of derivatives of CC-1065 |
JP3514490B2 (ja) | 1992-08-21 | 2004-03-31 | 杏林製薬株式会社 | トリフルオロメチルピロロインドールカルボン酸エステル誘導体及びその製造方法 |
GB9307491D0 (en) | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
AU689566B2 (en) | 1994-04-01 | 1998-04-02 | Kyowa Hakko Kogyo Co. Ltd. | DC-89 derivatives |
US5502068A (en) | 1995-01-31 | 1996-03-26 | Synphar Laboratories, Inc. | Cyclopropylpyrroloindole-oligopeptide anticancer agents |
DE19503320A1 (de) | 1995-02-02 | 1996-08-08 | Boehringer Mannheim Gmbh | Neue Benzodiazepinkonjugate |
US5843937A (en) | 1996-05-23 | 1998-12-01 | Panorama Research, Inc. | DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents |
WO1998011101A2 (en) | 1996-09-12 | 1998-03-19 | Cancer Research Campaign Technology Limited | Condensed n-aclyindoles as antitumor agents |
WO1998025900A1 (fr) | 1996-12-13 | 1998-06-18 | Shionogi & Co., Ltd. | Composes presentant une activite antitumorale |
US20030036629A1 (en) | 1997-12-12 | 2003-02-20 | Barry Foster | Novel tgf-beta protein purification methods |
US7214685B2 (en) | 2000-05-02 | 2007-05-08 | Lutz F. Tietze | Prodrugs for a selective cancer therapy |
JP5010089B2 (ja) | 2000-09-19 | 2012-08-29 | スピロジェン リミテッド | Cc−1065およびデュオカルマイシンのアキラルアナログの組成物およびその使用方法 |
EP1363908A4 (en) | 2001-01-24 | 2004-05-06 | Auckland Uniservices Ltd | ANTI-CANCER COMPLEXES 2,3-DIHYDRO-1H-PYRROLO 3,2-F] COBALT AND CHROME QUINOLINE |
US7192977B2 (en) | 2001-02-22 | 2007-03-20 | School Of Pharmacy | Benz-indole and benzo-quinoline derivatives as prodrugs for tumor treatment |
US7129261B2 (en) * | 2001-05-31 | 2006-10-31 | Medarex, Inc. | Cytotoxic agents |
US7514078B2 (en) | 2001-06-01 | 2009-04-07 | Cornell Research Foundation, Inc. | Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies |
CA2459308A1 (en) | 2001-09-07 | 2003-03-20 | Dale L. Boger | Cbi analogues of cc-1065 and the duocarmycins |
WO2003026577A2 (en) * | 2001-09-24 | 2003-04-03 | Seattle Genetics, Inc. | P-amidobenzylethers in drug delivery agents |
US6756397B2 (en) | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
US7235578B2 (en) | 2002-05-17 | 2007-06-26 | Auckland Uniservices Limited | Processes for preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3H-[ring fused indol-5-yl-(amine-derived)] compounds and analogues thereof, and to products obtained therefrom |
CA2494104A1 (en) * | 2002-07-31 | 2004-04-22 | Seattle Genetics, Inc. | Anti-cd20 antibody-drug conjugates for the treatment of cancer and immune disorders |
US7705045B2 (en) | 2002-11-14 | 2010-04-27 | Syntarga, B.V. | Prodrugs built as multiple self-elimination-release spacers |
ES2395082T3 (es) | 2003-01-27 | 2013-02-08 | Endocyte, Inc. | Conjugado de folato-vinblastina como medicamento |
US20070037739A1 (en) | 2003-02-03 | 2007-02-15 | Medlogics Device Corporation | Compounds useful in coating stents to prevent and treat stenosis and restenosis |
ATE472338T1 (de) | 2003-02-20 | 2010-07-15 | Seattle Genetics Inc | Anti-cd70 antikörper-arzneimittelkonjugate und ihre verwendung zur behandlung von krebs |
US20050026987A1 (en) | 2003-05-13 | 2005-02-03 | The Scripps Research Institute | CBI analogues of the duocarmycins and CC-1065 |
WO2005032594A2 (en) | 2003-10-03 | 2005-04-14 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Alkylators linked to polyamides as dna binding agents |
AU2005218642B2 (en) * | 2004-03-02 | 2011-04-28 | Seagen Inc. | Partially loaded antibodies and methods of their conjugation |
WO2005112919A2 (en) | 2004-05-19 | 2005-12-01 | Medarex, Inc. | Self-immolative linkers and drug conjugates |
TR201808537T4 (tr) | 2004-09-23 | 2018-07-23 | Genentech Inc | Sistein değiştirilmiş antikorlar ve konjugatlar. |
WO2006037052A2 (en) | 2004-09-27 | 2006-04-06 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health | Modulating mxa expression |
NZ536107A (en) | 2004-10-22 | 2007-06-29 | Auckland Uniservices Ltd | Nitrobenzindoles and their use in cancer therapy |
EP1858902A1 (en) | 2005-02-24 | 2007-11-28 | Pfizer Products Incorporated | Bicyclic heteroaromatic derivatives useful as anticancer agents |
NZ566982A (en) | 2005-09-26 | 2011-06-30 | Medarex Inc | Duocarmycin drug conjugates |
ATE534629T1 (de) | 2005-10-26 | 2011-12-15 | Medarex Inc | Verfahren und verbindungen zur herstellung von cc-1065-analoga |
BRPI0707426A2 (pt) | 2006-02-02 | 2011-05-03 | Syntarga Bv | composto, conjugado, uso de um composto, composição farmacêutica, processo para preparar uma composição farmacêutica, e, métodos de tratamento de um mamìfero estando em necessidade do mesmo, e de tratamento ou prevenção de um tumor em um mamìfero |
EP1832577A1 (en) | 2006-03-07 | 2007-09-12 | Sanofi-Aventis | Improved prodrugs of CC-1065 analogs |
ES2493166T3 (es) | 2006-11-01 | 2014-09-11 | Ventana Medical Systems, Inc. | Haptenos, conjugados de haptenos, composiciones de los mismos y método para su preparación y uso |
NZ578354A (en) | 2006-12-14 | 2012-01-12 | Medarex Inc | Antibody-partner molecule conjugates that bind cd70 and uses thereof |
KR20090122439A (ko) | 2007-02-21 | 2009-11-30 | 메다렉스, 인코포레이티드 | 단일 아미노산을 갖는 화학적 링커 및 이의 접합체 |
EP2173739B1 (en) | 2007-08-01 | 2013-07-31 | Syntarga B.V. | Substituted cc-1065 analogs and their conjugates |
US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
US8377981B2 (en) | 2007-11-13 | 2013-02-19 | The Scripps Research Institute | CBI derivatives subject to reductive activation |
US20090162372A1 (en) | 2007-11-30 | 2009-06-25 | Medarex, Inc. | Fibronectin ed-b antibodies, conjugates thereof, and methods of use |
NZ571028A (en) | 2008-09-03 | 2011-01-28 | Auckland Uniservices Ltd | Nitrobenzindole compounds and their use in cancer treatment |
NZ592255A (en) | 2008-09-17 | 2013-07-26 | Endocyte Inc | Folate receptor binding conjugates of antifolates |
EP2165710A1 (en) * | 2008-09-19 | 2010-03-24 | Institut Curie | Tyrosine kinase receptor Tyro3 as a therapeutic target in the treatment of a bladder tumor |
PT2344478T (pt) | 2008-11-03 | 2017-11-28 | Syntarga Bv | Análogos de cc-1065 e seus conjugados |
WO2010070117A1 (en) * | 2008-12-18 | 2010-06-24 | Universite Libre De Bruxelles | Treatment method by the administration of anti-her2 targeted active compounds to patients with early breast cancer and her2-negative primary tumor |
WO2011022316A1 (en) * | 2009-08-20 | 2011-02-24 | The Regents Of The University Of Colorado, A Body Corporate | Mirnas dysregulated in triple-negative breast cancer |
DK3056203T3 (da) | 2010-04-21 | 2018-01-29 | Syntarga Bv | Konjugater af cc-1065-analoger og bifunktionelle linkere. |
EP2380909A1 (en) * | 2010-04-26 | 2011-10-26 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | PTK-7 protein involved in breast cancer |
EP2575880B1 (en) * | 2010-05-27 | 2019-01-16 | Genmab A/S | Monoclonal antibodies against her2 epitope |
CA2832387A1 (en) * | 2011-04-20 | 2012-10-26 | Genmab A/S | Bispecifc antibodies against her2 |
US9958455B2 (en) | 2011-09-29 | 2018-05-01 | Seattle Genetics, Inc. | Intact mass determination of protein conjugated agent compounds |
IL301603A (en) * | 2011-10-14 | 2023-05-01 | Genentech Inc | Pertuzumab, trastuzumab, docetaxel and carboplatin for use in the preoperative treatment of a patient |
ES2721882T3 (es) | 2011-12-23 | 2019-08-06 | Pfizer | Regiones constantes de anticuerpo modificadas por ingeniería genética para conjugación específica de sitio y procedimientos y usos de las mismas |
EP2814512A1 (en) | 2012-02-16 | 2014-12-24 | UCL Business Plc. | Lysosome-cleavable linker |
SG11201605597VA (en) | 2014-01-10 | 2016-08-30 | Synthon Biopharmaceuticals Bv | Duocarmycin adcs for use in treatment of endometrial cancer |
CN105899236B (zh) | 2014-01-10 | 2019-07-26 | 斯索恩生物制药有限公司 | 表现出改进的体内抗肿瘤活性的倍癌霉素adc |
PL3092010T3 (pl) | 2014-01-10 | 2019-01-31 | Synthon Biopharmaceuticals B.V. | Sposób oczyszczania połączonych cysteiną koniugatów przeciwciało-lek |
SG10201913977TA (en) | 2014-05-22 | 2020-03-30 | Synthon Biopharmaceuticals Bv | Site-specific conjugation of linker drugs to antibodies and resulting adcs |
PL3152191T3 (pl) | 2014-06-05 | 2019-10-31 | Synthon Biopharmaceuticals Bv | Ulepszony sposób wytwarzania proleków duokarmycyny |
EP3197919A1 (en) | 2014-09-22 | 2017-08-02 | Synthon Biopharmaceuticals B.V. | Pan-reactive antibodies to duocarmycins |
LT3319597T (lt) | 2015-07-10 | 2021-07-26 | Byondis B.V. | Kompozicijos apimančios antikūno-vaisto duokarmicino konjugatus |
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