CL2016001348A1 - Crystalline form of hydrochloride of (s) - (2- (6-chloro-7-methyl-1h-benzo [d] imidazol-2-yl) -2-methylpyrrolidin-1-yl) (5-methoxy-2- ( 2h-1,2,3-triazol-2-yl) phenyl) methanone; pharmaceutical composition comprising it; and its use for the treatment or prevention of sleep disorders, such as dysomnias, parasomnias, among others. - Google Patents

Crystalline form of hydrochloride of (s) - (2- (6-chloro-7-methyl-1h-benzo [d] imidazol-2-yl) -2-methylpyrrolidin-1-yl) (5-methoxy-2- ( 2h-1,2,3-triazol-2-yl) phenyl) methanone; pharmaceutical composition comprising it; and its use for the treatment or prevention of sleep disorders, such as dysomnias, parasomnias, among others.

Info

Publication number
CL2016001348A1
CL2016001348A1 CL2016001348A CL2016001348A CL2016001348A1 CL 2016001348 A1 CL2016001348 A1 CL 2016001348A1 CL 2016001348 A CL2016001348 A CL 2016001348A CL 2016001348 A CL2016001348 A CL 2016001348A CL 2016001348 A1 CL2016001348 A1 CL 2016001348A1
Authority
CL
Chile
Prior art keywords
methyl
triazol
imidazol
benzo
phenyl
Prior art date
Application number
CL2016001348A
Other languages
Spanish (es)
Inventor
Markus Gude
Christoph Boss
Christine Brotschi
Bibia Heidmann
Thierry Sifferlen
Jodi T Williams
Raumer Markus Von
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of CL2016001348A1 publication Critical patent/CL2016001348A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

FORMA CRISTALINA DEL COMPUESTO S)-(2-(6-CLORO-7-METIL-1H-BENZO[D]IMIDAZOL-2-IL)-2-METIL-PIRROLIDIN-1-IL)(5-METOXI-2-(2H-1,2,3-TRIAZOL-2-IL)FENIL)METANONA SUS SALES, ANTAGONISTA DEL RECEPTOR DE OREXINA; COMPOSICION FARMACEUTICA; Y SU USO PARA EL TRATAMIENTO O PRECENCIPN DE NUN AENFERMEDAD O TRASTORNO SELECCIONADO DEL GRUPO ENTRE TRASTORNOS EL SUEÑO, TRASTORNOS DE ANSIEDAD, DE ADICCION DE HUMOR, DEL APETITO Y DISFUNCIONES COGNITIVAS.CRYSTAL FORM OF COMPOUND S) - (2- (6-CHLORINE-7-METHYL-1H-BENZO [D] IMIDAZOL-2-IL) -2-METHYL-PIRROLIDIN-1-IL) (5-METOXI-2- ( 2H-1,2,3-TRIAZOL-2-IL) PHENYL) METANONE ITS SALTS, OREXINE RECEIVER ANTAGONIST; PHARMACEUTICAL COMPOSITION; AND ITS USE FOR THE TREATMENT OR PREVENTION OF ANY DISEASE OR DISORDER SELECTED FROM THE GROUP BETWEEN SLEEP DISORDERS, ANXIETY DISORDERS, HUMOR ADDICTION, APPETITE AND COGNITIVE DYSFUNCTIONS.

CL2016001348A 2013-12-03 2016-06-02 Crystalline form of hydrochloride of (s) - (2- (6-chloro-7-methyl-1h-benzo [d] imidazol-2-yl) -2-methylpyrrolidin-1-yl) (5-methoxy-2- ( 2h-1,2,3-triazol-2-yl) phenyl) methanone; pharmaceutical composition comprising it; and its use for the treatment or prevention of sleep disorders, such as dysomnias, parasomnias, among others. CL2016001348A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2013060595 2013-12-03

Publications (1)

Publication Number Publication Date
CL2016001348A1 true CL2016001348A1 (en) 2016-11-25

Family

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Application Number Title Priority Date Filing Date
CL2016001348A CL2016001348A1 (en) 2013-12-03 2016-06-02 Crystalline form of hydrochloride of (s) - (2- (6-chloro-7-methyl-1h-benzo [d] imidazol-2-yl) -2-methylpyrrolidin-1-yl) (5-methoxy-2- ( 2h-1,2,3-triazol-2-yl) phenyl) methanone; pharmaceutical composition comprising it; and its use for the treatment or prevention of sleep disorders, such as dysomnias, parasomnias, among others.

Country Status (32)

Country Link
US (2) US9790208B2 (en)
EP (1) EP3077390B1 (en)
JP (1) JP6091716B2 (en)
KR (1) KR101839716B1 (en)
CN (1) CN105793258B (en)
AU (1) AU2014358743B2 (en)
CA (1) CA2929720C (en)
CL (1) CL2016001348A1 (en)
CY (1) CY1119687T1 (en)
DK (1) DK3077390T3 (en)
EA (1) EA030109B1 (en)
ES (1) ES2651508T3 (en)
HK (1) HK1225736B (en)
HR (1) HRP20171772T1 (en)
HU (1) HUE034656T2 (en)
IL (1) IL245922B (en)
LT (1) LT3077390T (en)
MA (1) MA39164B1 (en)
MX (1) MX362701B (en)
MY (1) MY176244A (en)
NO (1) NO3077390T3 (en)
NZ (1) NZ721493A (en)
PH (1) PH12016500989A1 (en)
PL (1) PL3077390T3 (en)
PT (1) PT3077390T (en)
SA (1) SA516371248B1 (en)
SG (1) SG11201604541WA (en)
SI (1) SI3077390T1 (en)
TW (1) TWI636982B (en)
UA (1) UA119151C2 (en)
WO (1) WO2015083071A1 (en)
ZA (1) ZA201604501B (en)

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EP3077390B1 (en) 2017-09-13
CA2929720C (en) 2019-06-18
TW201605839A (en) 2016-02-16
US10023560B2 (en) 2018-07-17
UA119151C2 (en) 2019-05-10
ZA201604501B (en) 2018-12-19
SI3077390T1 (en) 2017-12-29
IL245922B (en) 2019-10-31
LT3077390T (en) 2017-11-27
CY1119687T1 (en) 2018-04-04
US9790208B2 (en) 2017-10-17
AU2014358743B2 (en) 2018-11-29
JP6091716B2 (en) 2017-03-08
HK1225736B (en) 2017-09-15
IL245922A0 (en) 2016-08-02
CN105793258B (en) 2018-12-28
HUE034656T2 (en) 2018-02-28
HRP20171772T1 (en) 2017-12-29
JP2016539135A (en) 2016-12-15
EA201600436A1 (en) 2016-11-30
DK3077390T3 (en) 2017-11-06
CN105793258A (en) 2016-07-20
MX2016007216A (en) 2016-09-07
MX362701B (en) 2019-02-01
MA39164B1 (en) 2019-03-29
SA516371248B1 (en) 2018-03-19
SG11201604541WA (en) 2016-07-28
MY176244A (en) 2020-07-24
KR101839716B1 (en) 2018-03-16
US20160355506A1 (en) 2016-12-08
MA39164A1 (en) 2017-08-31
PT3077390T (en) 2017-12-15
US20180002317A1 (en) 2018-01-04
NO3077390T3 (en) 2018-02-10
WO2015083071A1 (en) 2015-06-11
PL3077390T3 (en) 2018-02-28
PH12016500989B1 (en) 2016-06-20
BR112016012625A8 (en) 2017-12-26
CA2929720A1 (en) 2015-06-11
AU2014358743A1 (en) 2016-07-14
NZ721493A (en) 2021-12-24
BR112016012625A2 (en) 2017-08-22
EP3077390A1 (en) 2016-10-12
EA030109B1 (en) 2018-06-29
PH12016500989A1 (en) 2016-06-20
TWI636982B (en) 2018-10-01
KR20160093683A (en) 2016-08-08
ES2651508T3 (en) 2018-01-26

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