MX364208B - Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol -2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2- yl)phenyl)methanone and its use as orexin receptor antagonists. - Google Patents
Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol -2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2- yl)phenyl)methanone and its use as orexin receptor antagonists.Info
- Publication number
- MX364208B MX364208B MX2016007215A MX2016007215A MX364208B MX 364208 B MX364208 B MX 364208B MX 2016007215 A MX2016007215 A MX 2016007215A MX 2016007215 A MX2016007215 A MX 2016007215A MX 364208 B MX364208 B MX 364208B
- Authority
- MX
- Mexico
- Prior art keywords
- methylpyrrolidin
- methanone
- triazol
- imidazol
- benzo
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention relates to crystalline forms of (S)-(2-(6-chloro-7-methyl-1H-benzo[d]imidazol-2- yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2H-1,2,3-triazol-2-yl )phenyl)methanone, processes for the preparation thereof, pharmaceutical compositions containing such crystalline forms, pharmaceutical compositions prepared from such crystalline forms, and their use as a medicament, especially as orexin receptor antagonists.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2013060596 | 2013-12-03 | ||
PCT/IB2014/066508 WO2015083070A1 (en) | 2013-12-03 | 2014-12-02 | Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2016007215A MX2016007215A (en) | 2016-09-07 |
MX364208B true MX364208B (en) | 2019-04-16 |
Family
ID=52282786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016007215A MX364208B (en) | 2013-12-03 | 2014-12-02 | Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol -2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2- yl)phenyl)methanone and its use as orexin receptor antagonists. |
Country Status (31)
Country | Link |
---|---|
US (1) | US9914720B2 (en) |
EP (1) | EP3077389B1 (en) |
JP (1) | JP6496733B2 (en) |
KR (1) | KR102361418B1 (en) |
CN (1) | CN105793257B (en) |
AU (1) | AU2014358742B2 (en) |
CA (1) | CA2929423C (en) |
CL (1) | CL2016001342A1 (en) |
CY (1) | CY1119695T1 (en) |
DK (1) | DK3077389T3 (en) |
EA (1) | EA030137B1 (en) |
ES (1) | ES2651475T3 (en) |
HK (1) | HK1225731B (en) |
HR (1) | HRP20171773T1 (en) |
HU (1) | HUE035731T2 (en) |
IL (1) | IL245923B (en) |
LT (1) | LT3077389T (en) |
MA (1) | MA39163B1 (en) |
MX (1) | MX364208B (en) |
MY (1) | MY179862A (en) |
NO (1) | NO3077389T3 (en) |
NZ (1) | NZ721438A (en) |
PH (1) | PH12016500988B1 (en) |
PL (1) | PL3077389T3 (en) |
PT (1) | PT3077389T (en) |
SA (1) | SA516371231B1 (en) |
SI (1) | SI3077389T1 (en) |
TW (1) | TWI664177B (en) |
UA (1) | UA119549C2 (en) |
WO (1) | WO2015083070A1 (en) |
ZA (1) | ZA201604499B (en) |
Families Citing this family (7)
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EA029899B1 (en) | 2012-06-04 | 2018-05-31 | Идорсиа Фармасьютиклз Лтд | Benzimidazole-proline derivatives |
UA119151C2 (en) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | Crystalline salt form of (s)-(2-(6-chloro-7-methyl-1 h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone as orexin receptor antagonist |
DK3077391T3 (en) | 2013-12-04 | 2018-10-22 | Idorsia Pharmaceuticals Ltd | USE OF BENZIMIDAZOLE PROLINE DERIVATIVES |
PL3619199T3 (en) | 2017-05-03 | 2021-12-20 | Idorsia Pharmaceuticals Ltd | Preparation of 2-([1,2,3]triazol-2-yl)-benzoic acid derivatives |
CA3175369A1 (en) | 2020-04-19 | 2021-10-28 | Guy Braunstein | Medical use of daridorexant |
CN116783182A (en) * | 2021-02-02 | 2023-09-19 | 南京明德新药研发有限公司 | Tetrahydropyrrole ring compound and application thereof |
WO2023160004A1 (en) * | 2022-02-25 | 2023-08-31 | 南京知和医药科技有限公司 | Fused-ring compound having analgesic activity, and preparation method therefor and use thereof |
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GB0115862D0 (en) | 2001-06-28 | 2001-08-22 | Smithkline Beecham Plc | Compounds |
GB0124463D0 (en) | 2001-10-11 | 2001-12-05 | Smithkline Beecham Plc | Compounds |
GB0127145D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Compounds |
GB0130335D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
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UA119151C2 (en) * | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | Crystalline salt form of (s)-(2-(6-chloro-7-methyl-1 h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone as orexin receptor antagonist |
DK3077391T3 (en) | 2013-12-04 | 2018-10-22 | Idorsia Pharmaceuticals Ltd | USE OF BENZIMIDAZOLE PROLINE DERIVATIVES |
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2014
- 2014-12-02 TW TW103141828A patent/TWI664177B/en active
- 2014-12-02 NZ NZ721438A patent/NZ721438A/en unknown
- 2014-12-02 JP JP2016536109A patent/JP6496733B2/en active Active
- 2014-12-02 LT LTEP14824107.8T patent/LT3077389T/en unknown
- 2014-12-02 CA CA2929423A patent/CA2929423C/en active Active
- 2014-12-02 PL PL14824107T patent/PL3077389T3/en unknown
- 2014-12-02 DK DK14824107.8T patent/DK3077389T3/en active
- 2014-12-02 AU AU2014358742A patent/AU2014358742B2/en active Active
- 2014-12-02 PT PT148241078T patent/PT3077389T/en unknown
- 2014-12-02 MX MX2016007215A patent/MX364208B/en active IP Right Grant
- 2014-12-02 MA MA39163A patent/MA39163B1/en unknown
- 2014-12-02 SI SI201430489T patent/SI3077389T1/en unknown
- 2014-12-02 EP EP14824107.8A patent/EP3077389B1/en active Active
- 2014-12-02 ES ES14824107.8T patent/ES2651475T3/en active Active
- 2014-12-02 HU HUE14824107A patent/HUE035731T2/en unknown
- 2014-12-02 NO NO14824107A patent/NO3077389T3/no unknown
- 2014-12-02 CN CN201480065274.7A patent/CN105793257B/en active Active
- 2014-12-02 KR KR1020167017644A patent/KR102361418B1/en active IP Right Grant
- 2014-12-02 WO PCT/IB2014/066508 patent/WO2015083070A1/en active Application Filing
- 2014-12-02 EA EA201600435A patent/EA030137B1/en not_active IP Right Cessation
- 2014-12-02 UA UAA201607114A patent/UA119549C2/en unknown
- 2014-12-02 MY MYPI2016701997A patent/MY179862A/en unknown
- 2014-12-02 US US15/101,768 patent/US9914720B2/en active Active
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2016
- 2016-05-26 PH PH12016500988A patent/PH12016500988B1/en unknown
- 2016-05-30 IL IL245923A patent/IL245923B/en active IP Right Grant
- 2016-05-30 SA SA516371231A patent/SA516371231B1/en unknown
- 2016-06-02 CL CL2016001342A patent/CL2016001342A1/en unknown
- 2016-07-01 ZA ZA2016/04499A patent/ZA201604499B/en unknown
- 2016-12-13 HK HK16114145A patent/HK1225731B/en unknown
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2017
- 2017-11-16 HR HRP20171773TT patent/HRP20171773T1/en unknown
- 2017-12-12 CY CY20171101301T patent/CY1119695T1/en unknown
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Owner name: IDORSIA PHARMACEUTICALS LTD |
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