CL2015002837A1 - Compuestos de piridinilpirazoloquinolina. - Google Patents

Compuestos de piridinilpirazoloquinolina.

Info

Publication number
CL2015002837A1
CL2015002837A1 CL2015002837A CL2015002837A CL2015002837A1 CL 2015002837 A1 CL2015002837 A1 CL 2015002837A1 CL 2015002837 A CL2015002837 A CL 2015002837A CL 2015002837 A CL2015002837 A CL 2015002837A CL 2015002837 A1 CL2015002837 A1 CL 2015002837A1
Authority
CL
Chile
Prior art keywords
compounds
pyridinylpyrazoloquinoline
piridinylpirazoloquinoline
phosphodesterase
pde9
Prior art date
Application number
CL2015002837A
Other languages
English (en)
Inventor
Yoshihiko Norimine
Kunitoshi Takeda
Yuki Ishihara
Nobuaki Sato
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of CL2015002837A1 publication Critical patent/CL2015002837A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

COMPUESTOS DERIVADOS DE PIRIDINILPIRAZOLOQUINOLINA, INHIBIDORES DE LA FOSFODIESTERASA 9 (PDE9); COMPOSICION FARMACEUTICA QUE LOS COMPRENDE; METODO PARA MEJORAR UNA DEFICIENCIA COGNITIVA EN LA ENFERMEDAD DE ALZHEIMER.
CL2015002837A 2013-04-05 2015-09-23 Compuestos de piridinilpirazoloquinolina. CL2015002837A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361809095P 2013-04-05 2013-04-05
US201361809118P 2013-04-05 2013-04-05

Publications (1)

Publication Number Publication Date
CL2015002837A1 true CL2015002837A1 (es) 2016-04-22

Family

ID=51658437

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2015002837A CL2015002837A1 (es) 2013-04-05 2015-09-23 Compuestos de piridinilpirazoloquinolina.

Country Status (20)

Country Link
US (1) US9550776B2 (es)
EP (1) EP2982674B1 (es)
JP (1) JP6244353B2 (es)
KR (1) KR102234131B1 (es)
CN (1) CN105189496B (es)
AU (1) AU2014250391B2 (es)
BR (1) BR112015024075B1 (es)
CA (1) CA2904820C (es)
CL (1) CL2015002837A1 (es)
ES (1) ES2654094T3 (es)
HK (1) HK1219100A1 (es)
IL (1) IL241695B (es)
MX (1) MX363258B (es)
PE (1) PE20151718A1 (es)
PH (1) PH12015502178A1 (es)
RU (1) RU2655172C2 (es)
SG (1) SG11201507733YA (es)
TW (1) TW201439091A (es)
WO (1) WO2014163146A1 (es)
ZA (1) ZA201507044B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201406486D0 (en) 2014-04-10 2014-05-28 Redx Pharma Ltd Antibacterial compounds
WO2017046606A1 (en) * 2015-09-18 2017-03-23 Redx Pharma Plc Antibacterial compounds
KR20200010220A (ko) 2017-06-01 2020-01-30 에자이 알앤드디 매니지먼트 가부시키가이샤 피라졸로퀴놀린 유도체를 함유하는 루이소체 질병 치료제
TWI802591B (zh) 2017-09-14 2023-05-21 日商第一三共股份有限公司 具有環狀構造的化合物
US11530218B2 (en) 2020-01-20 2022-12-20 Incyte Corporation Spiro compounds as inhibitors of KRAS
WO2021231526A1 (en) 2020-05-13 2021-11-18 Incyte Corporation Fused pyrimidine compounds as kras inhibitors
US11767320B2 (en) 2020-10-02 2023-09-26 Incyte Corporation Bicyclic dione compounds as inhibitors of KRAS
AU2022367432A1 (en) 2021-10-14 2024-05-02 Incyte Corporation Quinoline compounds as inhibitors of kras

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05132484A (ja) 1991-04-26 1993-05-28 Otsuka Pharmaceut Factory Inc ピラゾロキノリン及びピラゾロナフチリジン誘導体
JP2828506B2 (ja) 1994-05-24 1998-11-25 エフ・ホフマン−ラ ロシュ アーゲー 三環式ジカルボニル誘導体
DE102004004142A1 (de) * 2003-05-09 2004-11-25 Bayer Healthcare Ag 6-Cyclylmethyl- und 6-Alkylmethyl-substituierte Pyrazolopyrimidine
WO2005118583A1 (en) 2004-05-28 2005-12-15 Millennium Pharmaceuticals, Inc. 2, 5-dihydro-pyrazolo`4, 3-c!quinolin-4-ones as chk-1 inhibitors
JP2006045118A (ja) 2004-08-04 2006-02-16 Mochida Pharmaceut Co Ltd 新規ピラゾロキノロン誘導体
CN101268073B (zh) 2005-09-15 2011-10-19 Aska制药株式会社 杂环化合物、制备方法及其用途
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物
ES2536906T3 (es) 2006-12-13 2015-05-29 Aska Pharmaceutical Co., Ltd. Derivado de quinoxalina
NZ580904A (en) 2007-05-11 2012-02-24 Pfizer Amino-heterocyclic compounds for inhibiting pde9
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
CN102341399A (zh) * 2009-03-05 2012-02-01 安斯泰来制药株式会社 喹喔啉化合物
JP5542196B2 (ja) 2009-03-31 2014-07-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １−複素環−１，５−ジヒドロ−ピラゾロ［３，４−ｄ］ピリミジン−４−オン誘導体及びｐｄｅ９ａモジュレーターとしてのそれらの使用
ES2583528T3 (es) * 2010-09-07 2016-09-21 Astellas Pharma Inc. Compuesto de pirazoloquinolina
PT2573073E (pt) * 2011-09-26 2015-02-05 Sanofi Sa Derivados de pirazoloquinolinona, sua preparação e sua utilização terapêutica
JP6042060B2 (ja) 2011-09-26 2016-12-14 サノフイ ピラゾロキノリノン誘導体、その調製および治療上の使用
PL2769980T3 (pl) 2011-10-07 2016-07-29 Eisai R&D Man Co Ltd Pochodna pirazolochinoliny jako inhibitory PDE9

Also Published As

Publication number Publication date
EP2982674A1 (en) 2016-02-10
PH12015502178A1 (en) 2016-01-25
SG11201507733YA (en) 2015-10-29
BR112015024075A2 (pt) 2017-10-24
PE20151718A1 (es) 2015-11-22
TW201439091A (zh) 2014-10-16
EP2982674B1 (en) 2017-10-25
MX2015013446A (es) 2016-01-12
KR102234131B1 (ko) 2021-04-01
CA2904820C (en) 2021-05-18
RU2655172C2 (ru) 2018-05-24
ES2654094T3 (es) 2018-02-12
BR112015024075B1 (pt) 2022-05-03
IL241695B (en) 2019-06-30
CA2904820A1 (en) 2014-10-09
MX363258B (es) 2019-03-19
WO2014163146A1 (ja) 2014-10-09
JP6244353B2 (ja) 2017-12-06
AU2014250391A1 (en) 2015-10-15
EP2982674A4 (en) 2016-08-31
RU2015140669A3 (es) 2018-03-21
RU2015140669A (ru) 2017-05-11
ZA201507044B (en) 2017-02-22
AU2014250391B2 (en) 2017-11-02
US20160289225A1 (en) 2016-10-06
KR20150138204A (ko) 2015-12-09
US9550776B2 (en) 2017-01-24
HK1219100A1 (zh) 2017-03-24
CN105189496B (zh) 2017-03-29
JPWO2014163146A1 (ja) 2017-02-16
CN105189496A (zh) 2015-12-23

Similar Documents

Publication Publication Date Title
CL2015002837A1 (es) Compuestos de piridinilpirazoloquinolina.
DK3436461T3 (da) Pyrrolotriazinforbindelser som tam-inhibitorer
UY34559A (es) Inhibidores de bromodominios
UY34765A (es) Compuestos novedosos.
GT201400297A (es) Nuevos derivados tienopirimidina, un proceso para su preparación y composiciones farmacéuticas que los contienen
BR112015032718A2 (pt) composto de modificação de splicing do gene foxm1, uso do composto, formulação farmacêutica e métodos de triagem de compostos
EA201591137A1 (ru) Ингибиторы mk2 и их применения
CR20150049A (es) Anticuerpos e inmunoconjugados anti-cd79b
DK2970283T3 (da) Substituerede 2-aza-bicyclo[2.2.1]heptan-3-carboxylsyre-(benzyl-cyano-methyl)-amider som inhibitorer af cathepsin-c
UY34763A (es) Inhibidores de la agregación plaquetaria
UY34697A (es) Métodos para preparar análogos de nucleótidos
UY34515A (es) Triazolopiridinas sustituidas
UY34156A (es) Compuestos inhibidores de metaloenzimas
UY4235Q (es) Configuración aplicada en zapato
EA201690764A1 (ru) Ингибитор грелин-o-ацилтрансферазы
BR112013031493A2 (pt) composto, composição farmacêutica, uso de um composto, combinação de um composto, dispositivo e processo de preparação de um composto.
UY34654A (es) Inhibidores de la beta-secretasa
UY34730A (es) Formulaciones farmacéuticas que comprenden antagonistas de ccr3
CL2016001587A1 (es) Derivado basado en 1,2-naftoquinona y método de preparación del mismo.
EA201790312A1 (ru) Комбинации лекарственных средств для лечения множественной миеломы
EA201600121A1 (ru) Новые индольные и пиррольные соединения, способ их получения и фармацевтические композиции, содержащие их
CL2015002358A1 (es) Compuestos bicíclicos.
UY34791A (es) N-etil-4-hidroxil-1-metil-5-(metil(2,3,4,5,6-pentahidroxihexil)amino)-2-oxo-n-fenil-1,2- dihidroquinolina-3-carboxamida
CL2016001488A1 (es) Quinazolin-thf-aminas como inhibidores de pde1
UY34677A (es) Imidazopiridazinas sustituidas