CL2015002720A1 - Composición y kit farmacéutico de un polipéptido quimérico del factor viii y fc. - Google Patents
Composición y kit farmacéutico de un polipéptido quimérico del factor viii y fc.Info
- Publication number
- CL2015002720A1 CL2015002720A1 CL2015002720A CL2015002720A CL2015002720A1 CL 2015002720 A1 CL2015002720 A1 CL 2015002720A1 CL 2015002720 A CL2015002720 A CL 2015002720A CL 2015002720 A CL2015002720 A CL 2015002720A CL 2015002720 A1 CL2015002720 A1 CL 2015002720A1
- Authority
- CL
- Chile
- Prior art keywords
- composition
- factor viii
- chimeric polypeptide
- fviii
- pharmaceutical kit
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La invención describe una composición farmacéutica que comprende un polipéptido FVIII, particularmente una proteína de fusión que comprende FVIII recombinante sin el dominio B y una región Fc, más los excipientes: sacarosa, cloruro de sodio, L-histidina, cloruro de calcio dihidratado y polisorbato 80 o 20. También reivindica un kit que comprende un primer recipiente que comprende polvo liofilizado con FVIII y un segundo recipiente agua esterilizada con un volumen suficiente cuando se combina con el polvo liofilizado del primer recipiente una composición que comprende FVIII recombinante sin el dominio B y una región Fc, sacarosa, cloruro de sodio, L-histidina, cloruro de calcio dihidratado y polisorbato 80 o 20.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361800293P | 2013-03-15 | 2013-03-15 | |
US201361817085P | 2013-04-29 | 2013-04-29 | |
US201361829884P | 2013-05-31 | 2013-05-31 | |
US201361839477P | 2013-06-26 | 2013-06-26 | |
US201361863860P | 2013-08-08 | 2013-08-08 | |
US201361876927P | 2013-09-12 | 2013-09-12 | |
US201361879955P | 2013-09-19 | 2013-09-19 | |
US201361897742P | 2013-10-30 | 2013-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015002720A1 true CL2015002720A1 (es) | 2016-11-04 |
Family
ID=50771579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015002720A CL2015002720A1 (es) | 2013-03-15 | 2015-09-15 | Composición y kit farmacéutico de un polipéptido quimérico del factor viii y fc. |
Country Status (21)
Country | Link |
---|---|
US (3) | US9623088B2 (es) |
EP (3) | EP4122487A1 (es) |
JP (5) | JP6330026B2 (es) |
AU (3) | AU2014228506A1 (es) |
CA (1) | CA2899737A1 (es) |
CL (1) | CL2015002720A1 (es) |
DK (1) | DK2968477T3 (es) |
EA (2) | EA201890671A1 (es) |
ES (2) | ES2776195T3 (es) |
HK (1) | HK1220617A1 (es) |
HU (1) | HUE047933T2 (es) |
LT (1) | LT2968477T (es) |
PH (2) | PH12015501801A1 (es) |
PL (2) | PL2968477T3 (es) |
PT (2) | PT2968477T (es) |
RS (1) | RS60003B1 (es) |
SG (2) | SG11201505924TA (es) |
SI (1) | SI2968477T1 (es) |
TW (2) | TWI629993B (es) |
UY (1) | UY35462A (es) |
WO (1) | WO2014144795A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10201907152YA (en) * | 2009-12-06 | 2019-09-27 | Bioverativ Therapeutics Inc | Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof |
TWI828269B (zh) | 2013-03-15 | 2024-01-01 | 美商百歐維拉提夫治療公司 | 因子ix多肽調配物 |
EA201890671A1 (ru) * | 2013-03-15 | 2019-01-31 | Биовератив Терапьютикс Инк. | Препараты полипептида фактора viii |
CN107759694B (zh) | 2016-08-19 | 2023-01-13 | 安源医药科技(上海)有限公司 | 双特异性抗体及其制备方法与用途 |
CN106279437B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技(上海)有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
WO2018102743A1 (en) | 2016-12-02 | 2018-06-07 | Bioverativ Therapeutics Inc. | Methods of treating hemophilic arthropathy using chimeric clotting factors |
MX2019006446A (es) | 2016-12-02 | 2019-12-11 | Bioverativ Therapeutics Inc | Métodos para inducir tolerancia inmunológica a factores de coagulación. |
JP7039308B2 (ja) * | 2017-02-08 | 2022-03-22 | 三洋化成工業株式会社 | 細胞培養用担体 |
KR20200035130A (ko) | 2017-08-09 | 2020-04-01 | 바이오버라티브 테라퓨틱스 인크. | 핵산 분자 및 이의 용도 |
CN111655230A (zh) * | 2017-11-07 | 2020-09-11 | 拉尼医疗有限公司 | 使用可吞服药物递送装置递送到肠道组织中的凝血因子制剂 |
US12030925B2 (en) | 2018-05-18 | 2024-07-09 | Bioverativ Therapeutics Inc. | Methods of treating hemophilia A |
BR112021002017A2 (pt) | 2018-08-09 | 2021-05-11 | Bioverativ Therapeutics Inc. | moléculas de ácido nucleico e usos das mesmas para terapia genética não viral |
WO2020086686A2 (en) * | 2018-10-23 | 2020-04-30 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor viii function |
JP7501875B2 (ja) * | 2019-02-28 | 2024-06-18 | 公立大学法人横浜市立大学 | 血液凝固および/または補体異常疾患の治療用組成物 |
EP3956456A1 (en) | 2019-04-17 | 2022-02-23 | Codiak BioSciences, Inc. | Compositions of exosomes and aav |
JP2022537200A (ja) | 2019-06-19 | 2022-08-24 | バイオベラティブ セラピューティクス インコーポレイテッド | 血友病および低骨ミネラル密度を処置するための方法および組成物 |
KR20230159284A (ko) * | 2022-05-10 | 2023-11-21 | 주식회사 녹십자 | 혈장 단백질에 대한 신규한 액상 제형물 |
WO2023219379A1 (ko) * | 2022-05-10 | 2023-11-16 | 주식회사 녹십자 | 혈장 단백질의 동결 건조를 위한 신규한 액상 제형물 |
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SG10201907152YA (en) * | 2009-12-06 | 2019-09-27 | Bioverativ Therapeutics Inc | Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof |
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EP3943102A1 (en) * | 2012-10-30 | 2022-01-26 | Bioverativ Therapeutics Inc. | Methods of using fviii polypeptide |
EA201890671A1 (ru) * | 2013-03-15 | 2019-01-31 | Биовератив Терапьютикс Инк. | Препараты полипептида фактора viii |
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2014
- 2014-03-14 EA EA201890671A patent/EA201890671A1/ru unknown
- 2014-03-14 TW TW103109616A patent/TWI629993B/zh active
- 2014-03-14 LT LTEP14725816.4T patent/LT2968477T/lt unknown
- 2014-03-14 PL PL14725816T patent/PL2968477T3/pl unknown
- 2014-03-14 RS RS20200243A patent/RS60003B1/sr unknown
- 2014-03-14 PT PT147258164T patent/PT2968477T/pt unknown
- 2014-03-14 AU AU2014228506A patent/AU2014228506A1/en not_active Abandoned
- 2014-03-14 ES ES14725816T patent/ES2776195T3/es active Active
- 2014-03-14 ES ES19212900T patent/ES2926798T3/es active Active
- 2014-03-14 SI SI201431514T patent/SI2968477T1/sl unknown
- 2014-03-14 EA EA201591439A patent/EA030357B1/ru unknown
- 2014-03-14 EP EP22176875.7A patent/EP4122487A1/en active Pending
- 2014-03-14 US US14/213,180 patent/US9623088B2/en active Active
- 2014-03-14 EP EP19212900.5A patent/EP3666283B1/en active Active
- 2014-03-14 HU HUE14725816A patent/HUE047933T2/hu unknown
- 2014-03-14 SG SG11201505924TA patent/SG11201505924TA/en unknown
- 2014-03-14 DK DK14725816.4T patent/DK2968477T3/da active
- 2014-03-14 WO PCT/US2014/029354 patent/WO2014144795A1/en active Application Filing
- 2014-03-14 PT PT192129005T patent/PT3666283T/pt unknown
- 2014-03-14 JP JP2016503069A patent/JP6330026B2/ja active Active
- 2014-03-14 EP EP14725816.4A patent/EP2968477B1/en active Active
- 2014-03-14 SG SG10201805207QA patent/SG10201805207QA/en unknown
- 2014-03-14 PL PL19212900.5T patent/PL3666283T3/pl unknown
- 2014-03-14 UY UY0001035462A patent/UY35462A/es not_active Application Discontinuation
- 2014-03-14 TW TW107113370A patent/TWI690325B/zh active
- 2014-03-14 CA CA2899737A patent/CA2899737A1/en active Pending
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2015
- 2015-08-14 PH PH12015501801A patent/PH12015501801A1/en unknown
- 2015-09-15 CL CL2015002720A patent/CL2015002720A1/es unknown
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2016
- 2016-07-20 HK HK16108672.0A patent/HK1220617A1/zh unknown
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2017
- 2017-03-09 US US15/455,043 patent/US10786554B2/en active Active
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2018
- 2018-04-23 JP JP2018082321A patent/JP2018123161A/ja not_active Ceased
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2019
- 2019-04-16 AU AU2019202656A patent/AU2019202656B2/en active Active
- 2019-10-30 PH PH12019502452A patent/PH12019502452A1/en unknown
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2020
- 2020-08-14 US US16/993,979 patent/US20210069300A1/en active Pending
- 2020-08-19 JP JP2020138637A patent/JP6934994B2/ja active Active
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2021
- 2021-08-24 JP JP2021136162A patent/JP7240457B2/ja active Active
- 2021-11-29 AU AU2021277601A patent/AU2021277601A1/en active Pending
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2023
- 2023-03-03 JP JP2023032892A patent/JP2023060146A/ja active Pending
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