CL2015001241A1 - Uso de interleucina 2 (il-2) para tratar trastornos inflamatorios o relacionados con la autoinmunidad (div. sol. n° 2608-13) - Google Patents
Uso de interleucina 2 (il-2) para tratar trastornos inflamatorios o relacionados con la autoinmunidad (div. sol. n° 2608-13)Info
- Publication number
- CL2015001241A1 CL2015001241A1 CL2015001241A CL2015001241A CL2015001241A1 CL 2015001241 A1 CL2015001241 A1 CL 2015001241A1 CL 2015001241 A CL2015001241 A CL 2015001241A CL 2015001241 A CL2015001241 A CL 2015001241A CL 2015001241 A1 CL2015001241 A1 CL 2015001241A1
- Authority
- CL
- Chile
- Prior art keywords
- autoimmune
- div
- interleukin
- sol
- related disorders
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
La presente invención se refiere tratamientos novedosos basados en IL-2 para tratar enfermedades autoinmunes e inflamatorias. De forma más específica, la presente invención se refiere al uso de una dosis baja de IL-2 para el tratamiento de la diabetes de tipo I y otras enfermedades autoinmunes y/o inflamatorias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161451663P | 2011-03-11 | 2011-03-11 | |
EP11305269 | 2011-03-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015001241A1 true CL2015001241A1 (es) | 2015-08-14 |
Family
ID=57232567
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2013002608A CL2013002608A1 (es) | 2011-03-11 | 2013-09-10 | Uso de dosis bajas de il -2 para tratar transtornos inflamatorios y relacionados con la autoinmunidad |
CL2015001241A CL2015001241A1 (es) | 2011-03-11 | 2015-05-08 | Uso de interleucina 2 (il-2) para tratar trastornos inflamatorios o relacionados con la autoinmunidad (div. sol. n° 2608-13) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2013002608A CL2013002608A1 (es) | 2011-03-11 | 2013-09-10 | Uso de dosis bajas de il -2 para tratar transtornos inflamatorios y relacionados con la autoinmunidad |
Country Status (5)
Country | Link |
---|---|
US (4) | US9669071B2 (es) |
JP (3) | JP6416855B2 (es) |
BR (1) | BR112013023151A2 (es) |
CL (2) | CL2013002608A1 (es) |
ES (1) | ES2811624T3 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2811624T3 (es) | 2011-03-11 | 2021-03-12 | Hopitaux Paris Assist Publique | Régimen de dosificación de IL-2 para tratar lupus eritematoso sistémico |
HUE039577T2 (hu) | 2011-06-01 | 2019-01-28 | Intrexon Actobiotics Nv | Policisztronos expressziós rendszer baktériumokhoz |
WO2015162124A1 (en) * | 2014-04-22 | 2015-10-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnostic of an autoimmune disease |
SG11201700629TA (en) | 2014-08-11 | 2017-02-27 | Delinia Inc | Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases |
GB201515244D0 (en) * | 2015-08-27 | 2015-10-14 | Univ Birmingham | Treatment of inflammatory disease or condition |
EP3402499B1 (en) | 2016-01-14 | 2021-07-21 | Intrexon Actobiotics NV | Compositions and methods for the treatment of type 1 diabetes |
US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
US11077172B2 (en) | 2016-11-08 | 2021-08-03 | Delinia, Inc. | IL-2 variants for the treatment of psoriasis |
CA3056630A1 (en) | 2017-03-15 | 2018-09-20 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
CA3064435A1 (en) | 2017-05-24 | 2018-11-29 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
EP3927368A4 (en) | 2019-02-20 | 2022-10-19 | KSL Biomedical Inc. | METHODS FOR PREDICTING AND MONITORING THE EFFECTIVENESS OF LOW-DOSE IL-2 AND HYDROXYCHLOROQUINE THERAPY IN AUTOIMMUNE DISEASES AND ITS LONG-TERM USE IN AUTOIMMUNE-RELATED DISORDERS |
CN109999179A (zh) * | 2019-05-08 | 2019-07-12 | 山东省分析测试中心 | 低剂量白介素2用于制备治疗阿尔茨海默病药物中的应用 |
BR112021023345A2 (pt) | 2019-05-20 | 2022-02-01 | Pandion Operations Inc | Imunotolerância com alvo em madcam |
US20210059962A1 (en) * | 2019-09-03 | 2021-03-04 | Regen BioPharma, Inc. | Stimulation of t regulatory cells by cannabidiol as a means of treating arthritis and autoimmunity |
WO2021127557A1 (en) * | 2019-12-18 | 2021-06-24 | Washington University | Compositions and methods for treatment of headache disorders and neuropathic pain |
KR102653906B1 (ko) | 2020-01-14 | 2024-04-03 | 신테카인, 인크. | 편향된 il2 뮤테인 방법 및 조성물 |
WO2022031884A2 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il2rg binding molecules and methods of use |
WO2022150788A2 (en) | 2021-01-11 | 2022-07-14 | Synthekine, Inc. | Compositions and methods related to receptor pairing |
WO2024043975A1 (en) * | 2022-08-25 | 2024-02-29 | Board Of Regents Of The University Of Nebraska | Induction and expansion of regulatory t cells |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63183538A (ja) * | 1986-09-01 | 1988-07-28 | Takeda Chem Ind Ltd | 関節リウマチまたは全身性エリテマト−デスの改善,治療剤 |
EP0262802A3 (en) | 1986-09-01 | 1990-01-31 | Takeda Chemical Industries, Ltd. | Medicament for the treatment or improvement of rheumatoid arthritis or systemic lupus erythematosus |
US5466447A (en) | 1988-06-29 | 1995-11-14 | Amgen Inc. | Method for treating psoriasis |
AU7578091A (en) | 1990-03-19 | 1991-10-21 | Brigham And Women's Hospital | Treatment of cachexia with interleukin 2 |
US5466477A (en) | 1993-11-08 | 1995-11-14 | Hawkins Chemical, Inc. | Preparation of process cheese using liquid sodium phosphate |
FR2769505B1 (fr) | 1997-10-10 | 2000-06-30 | Michael Gerard Tovey | Compositions de cytokines a administrer a la muqueuse buccale, et leurs utilisations |
GB9724838D0 (en) | 1997-11-26 | 1998-01-21 | Franks Christopher R | Compositions |
AU2002258606A1 (en) | 2001-03-30 | 2002-10-15 | Mayo Foundation For Medical Education And Research | Aerosol administration of interleukin-2 liposomes |
ATE441420T1 (de) * | 2002-12-02 | 2009-09-15 | Innate Pharma | Interleukin-2 und gamma delta t zellaktivator enthaltende zusammensetzungen und deren verwendungen |
WO2005007121A2 (en) | 2003-07-18 | 2005-01-27 | Massachusetts Institute Of Technology | Mutant interleukin-2(il-2) polypeptides |
US20070098685A1 (en) * | 2005-01-19 | 2007-05-03 | Brand Stephen J | Methods and kits to treat chronic inflammatory immune diseases by administering a proteasome inhibitor and an interleukin 2 receptor agonist |
CA2595959A1 (en) * | 2005-01-27 | 2006-08-03 | Novartis Vaccines And Diagnostics, Inc. | Methods for treating renal cell carcinoma |
RU2540018C2 (ru) | 2008-03-13 | 2015-01-27 | Биотест Аг | Средство для лечения заболевания |
DE102008023820A1 (de) | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
WO2010049438A2 (en) | 2008-10-30 | 2010-05-06 | Innate Pharma | Improved methods of using phosphoantigens for the treatment of diseases |
CA2749539C (en) | 2009-01-21 | 2022-07-19 | Amgen Inc. | Compositions and methods comprising interleukin-2 mutants for treating inflammatory and autoimmune diseases |
CN102462837B (zh) | 2010-11-19 | 2016-08-03 | 生物林格斯Ip有限公司 | 抗炎组合物 |
ES2811624T3 (es) | 2011-03-11 | 2021-03-12 | Hopitaux Paris Assist Publique | Régimen de dosificación de IL-2 para tratar lupus eritematoso sistémico |
-
2012
- 2012-03-09 ES ES18179669T patent/ES2811624T3/es active Active
- 2012-03-09 US US14/004,211 patent/US9669071B2/en active Active
- 2012-03-09 BR BR112013023151-3A patent/BR112013023151A2/pt not_active Application Discontinuation
-
2013
- 2013-09-10 CL CL2013002608A patent/CL2013002608A1/es unknown
-
2015
- 2015-05-08 CL CL2015001241A patent/CL2015001241A1/es unknown
-
2016
- 2016-12-01 JP JP2016234087A patent/JP6416855B2/ja active Active
-
2017
- 2017-05-05 US US15/588,226 patent/US10293028B2/en active Active
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2018
- 2018-10-04 JP JP2018189159A patent/JP2019014743A/ja active Pending
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2019
- 2019-03-22 US US16/361,902 patent/US10765723B2/en active Active
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2020
- 2020-07-10 US US16/925,983 patent/US11559566B2/en active Active
- 2020-10-22 JP JP2020177184A patent/JP2021006591A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US10765723B2 (en) | 2020-09-08 |
US11559566B2 (en) | 2023-01-24 |
US9669071B2 (en) | 2017-06-06 |
JP6416855B2 (ja) | 2018-10-31 |
CL2013002608A1 (es) | 2014-05-30 |
ES2811624T3 (es) | 2021-03-12 |
JP2019014743A (ja) | 2019-01-31 |
JP2021006591A (ja) | 2021-01-21 |
US20170304402A1 (en) | 2017-10-26 |
US20190351023A1 (en) | 2019-11-21 |
US10293028B2 (en) | 2019-05-21 |
JP2017061551A (ja) | 2017-03-30 |
US20210038691A1 (en) | 2021-02-11 |
BR112013023151A2 (pt) | 2020-09-15 |
US20140004080A1 (en) | 2014-01-02 |
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