CL2014003026A1 - Compuestos heterobiciclicos derivados de imidazopiridina, imidazopirazina, triazolopiridina y triazolopirazina, inhibidores de la actividad nampt; composicion farmaceutica que los comprende; y metodo para tratar trastornos inflamatorios y de reparacion de tejido, dermatosis y enfermadades autoinmunes. - Google Patents
Compuestos heterobiciclicos derivados de imidazopiridina, imidazopirazina, triazolopiridina y triazolopirazina, inhibidores de la actividad nampt; composicion farmaceutica que los comprende; y metodo para tratar trastornos inflamatorios y de reparacion de tejido, dermatosis y enfermadades autoinmunes.Info
- Publication number
- CL2014003026A1 CL2014003026A1 CL2014003026A CL2014003026A CL2014003026A1 CL 2014003026 A1 CL2014003026 A1 CL 2014003026A1 CL 2014003026 A CL2014003026 A CL 2014003026A CL 2014003026 A CL2014003026 A CL 2014003026A CL 2014003026 A1 CL2014003026 A1 CL 2014003026A1
- Authority
- CL
- Chile
- Prior art keywords
- triazolopyrazine
- imidazopyrazine
- triazolopyridine
- imidazopyridine
- dermatosis
- Prior art date
Links
- ZKAMEFMDQNTDFK-UHFFFAOYSA-N 1h-imidazo[4,5-b]pyrazine Chemical compound C1=CN=C2NC=NC2=N1 ZKAMEFMDQNTDFK-UHFFFAOYSA-N 0.000 title 1
- CJGGKSPGRJHZNP-UHFFFAOYSA-N 2h-triazolo[4,5-b]pyrazine Chemical compound C1=CN=C2NN=NC2=N1 CJGGKSPGRJHZNP-UHFFFAOYSA-N 0.000 title 1
- GAMYYCRTACQSBR-UHFFFAOYSA-N 4-azabenzimidazole Chemical compound C1=CC=C2NC=NC2=N1 GAMYYCRTACQSBR-UHFFFAOYSA-N 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 206010048768 Dermatosis Diseases 0.000 title 1
- 102100033223 Nicotinamide phosphoribosyltransferase Human genes 0.000 title 1
- 108010064862 Nicotinamide phosphoribosyltransferase Proteins 0.000 title 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 208000035475 disorder Diseases 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000017520 skin disease Diseases 0.000 title 1
- 230000017423 tissue regeneration Effects 0.000 title 1
- OVCXRBARSPBVMC-UHFFFAOYSA-N triazolopyridine Chemical compound C=1N2C(C(C)C)=NN=C2C=CC=1C=1OC=NC=1C1=CC=C(F)C=C1 OVCXRBARSPBVMC-UHFFFAOYSA-N 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/47—Quinolines; Isoquinolines
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
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- Hematology (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201261645679P | 2012-05-11 | 2012-05-11 | |
US201261718998P | 2012-10-26 | 2012-10-26 | |
US201361779626P | 2013-03-13 | 2013-03-13 |
Publications (1)
Publication Number | Publication Date |
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CL2014003026A1 true CL2014003026A1 (es) | 2014-12-26 |
Family
ID=48576512
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CL2014003026A CL2014003026A1 (es) | 2012-05-11 | 2014-11-07 | Compuestos heterobiciclicos derivados de imidazopiridina, imidazopirazina, triazolopiridina y triazolopirazina, inhibidores de la actividad nampt; composicion farmaceutica que los comprende; y metodo para tratar trastornos inflamatorios y de reparacion de tejido, dermatosis y enfermadades autoinmunes. |
Country Status (25)
Country | Link |
---|---|
US (4) | US9187472B2 (es) |
EP (1) | EP2847192A1 (es) |
JP (1) | JP2015516435A (es) |
KR (1) | KR20150007349A (es) |
CN (1) | CN104428301A (es) |
AR (1) | AR091022A1 (es) |
AU (1) | AU2013259344A1 (es) |
BR (1) | BR112014028042A2 (es) |
CA (1) | CA2873060A1 (es) |
CL (1) | CL2014003026A1 (es) |
CO (1) | CO7151512A2 (es) |
CR (1) | CR20140573A (es) |
DO (1) | DOP2014000253A (es) |
EC (1) | ECSP14030779A (es) |
HK (2) | HK1208221A1 (es) |
IL (1) | IL235354A0 (es) |
MX (1) | MX2014013734A (es) |
PE (1) | PE20150224A1 (es) |
PH (1) | PH12014502513A1 (es) |
RU (1) | RU2014150049A (es) |
SG (1) | SG11201407372UA (es) |
TW (1) | TW201350481A (es) |
UA (1) | UA114323C2 (es) |
WO (1) | WO2013170112A1 (es) |
ZA (1) | ZA201407904B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR091022A1 (es) * | 2012-05-11 | 2014-12-30 | Abbvie Inc | Inhibidores del nampt |
US9266891B2 (en) | 2012-11-16 | 2016-02-23 | Boehringer Ingelheim International Gmbh | Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors |
US10144742B2 (en) | 2014-04-18 | 2018-12-04 | Millennium Pharmaceuticals, Inc. | Quinoxaline compounds and uses thereof |
TW201625641A (zh) * | 2014-05-22 | 2016-07-16 | 健臻公司 | Nampt抑制劑及方法 |
CN106459067B (zh) * | 2014-06-25 | 2019-05-31 | 豪夫迈·罗氏有限公司 | 用于治疗脊髓性肌萎缩的咪唑并[1,2-a]吡嗪-1基苯甲酰胺化合物 |
SG11201700039TA (en) * | 2014-07-23 | 2017-02-27 | Aurigene Discovery Tech Ltd | 4,5-dihydroisoxazole derivatives as nampt inhibitors |
CA2974078A1 (en) | 2015-01-20 | 2016-07-28 | Millennium Pharmaceuticals, Inc. | Quinazoline and quinoline compounds and uses thereof |
CN108290878B (zh) * | 2015-10-23 | 2022-04-26 | 威佛(国际)股份公司 | 新的膜铁转运蛋白抑制剂 |
JPWO2017170826A1 (ja) * | 2016-03-30 | 2019-02-14 | 味の素株式会社 | グルカゴン様ペプチド−1受容体作用増強活性を有する化合物 |
EP3279192A1 (en) * | 2016-08-05 | 2018-02-07 | Centre Hospitalier Universitaire Vaudois (CHUV) | Piperidine derivatives for use in the treatment of pancreatic cancer |
CN109843334A (zh) | 2016-10-18 | 2019-06-04 | 西雅图基因公司 | 烟酰胺腺嘌呤二核苷酸补救途径抑制剂的靶向递送 |
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2013
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- 2013-05-10 WO PCT/US2013/040476 patent/WO2013170112A1/en active Application Filing
- 2013-05-10 MX MX2014013734A patent/MX2014013734A/es unknown
- 2013-05-10 AU AU2013259344A patent/AU2013259344A1/en not_active Abandoned
- 2013-05-10 BR BR112014028042A patent/BR112014028042A2/pt not_active IP Right Cessation
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- 2013-05-10 UA UAA201413266A patent/UA114323C2/uk unknown
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- 2013-05-10 KR KR1020147034748A patent/KR20150007349A/ko not_active Application Discontinuation
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EP2847192A1 (en) | 2015-03-18 |
JP2015516435A (ja) | 2015-06-11 |
CO7151512A2 (es) | 2014-12-29 |
SG11201407372UA (en) | 2014-12-30 |
PE20150224A1 (es) | 2015-03-08 |
TW201350481A (zh) | 2013-12-16 |
CA2873060A1 (en) | 2013-11-14 |
BR112014028042A2 (pt) | 2017-06-27 |
US9187472B2 (en) | 2015-11-17 |
US20160184282A1 (en) | 2016-06-30 |
US20130303511A1 (en) | 2013-11-14 |
US20160184281A1 (en) | 2016-06-30 |
ECSP14030779A (es) | 2015-09-30 |
HK1208450A1 (en) | 2016-03-04 |
AR091022A1 (es) | 2014-12-30 |
HK1208221A1 (en) | 2016-02-26 |
CR20140573A (es) | 2015-02-25 |
PH12014502513A1 (en) | 2014-12-15 |
RU2014150049A (ru) | 2016-07-10 |
IL235354A0 (en) | 2014-12-31 |
MX2014013734A (es) | 2015-06-10 |
DOP2014000253A (es) | 2015-01-15 |
AU2013259344A1 (en) | 2014-11-13 |
WO2013170112A1 (en) | 2013-11-14 |
US9193723B2 (en) | 2015-11-24 |
KR20150007349A (ko) | 2015-01-20 |
CN104428301A (zh) | 2015-03-18 |
US20170135994A9 (en) | 2017-05-18 |
US20130303508A1 (en) | 2013-11-14 |
ZA201407904B (en) | 2017-08-30 |
UA114323C2 (uk) | 2017-05-25 |
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