CL2010001442A1 - Procedimiento de preparacion de una n-piridil-etoxicarboniletil-amida de un acido benzimidazolico, como intermediarios en la sintesis de etexilato de dabiogatran. - Google Patents

Procedimiento de preparacion de una n-piridil-etoxicarboniletil-amida de un acido benzimidazolico, como intermediarios en la sintesis de etexilato de dabiogatran.

Info

Publication number
CL2010001442A1
CL2010001442A1 CL2010001442A CL2010001442A CL2010001442A1 CL 2010001442 A1 CL2010001442 A1 CL 2010001442A1 CL 2010001442 A CL2010001442 A CL 2010001442A CL 2010001442 A CL2010001442 A CL 2010001442A CL 2010001442 A1 CL2010001442 A1 CL 2010001442A1
Authority
CL
Chile
Prior art keywords
ethoxycarbonylethyl
pyridyl
amide
synthesis
acid
Prior art date
Application number
CL2010001442A
Other languages
English (en)
Inventor
Rainer Hamm
Georg Zerban
Arndt Hausherr
Gunter Koch
Wolfgang Dersch
Christian Filser
Ulrich Scholz
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39863126&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2010001442(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2010001442A1 publication Critical patent/CL2010001442A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Procedimiento para la preparación de n-(2-piridil)-n-(2-etoxicarboniletil)-amida-sal del ácido 1-metil-2-[n-[4-amidinofenil]-amino-metil]-bencimidazol-5-il-carboxílico, producto intermedio en la síntesis de etexilato de dabigatran.
CL2010001442A 2008-06-16 2010-12-15 Procedimiento de preparacion de una n-piridil-etoxicarboniletil-amida de un acido benzimidazolico, como intermediarios en la sintesis de etexilato de dabiogatran. CL2010001442A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08158364 2008-06-16

Publications (1)

Publication Number Publication Date
CL2010001442A1 true CL2010001442A1 (es) 2011-05-13

Family

ID=39863126

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2010001442A CL2010001442A1 (es) 2008-06-16 2010-12-15 Procedimiento de preparacion de una n-piridil-etoxicarboniletil-amida de un acido benzimidazolico, como intermediarios en la sintesis de etexilato de dabiogatran.

Country Status (20)

Country Link
US (1) US8471033B2 (es)
EP (1) EP2297132B1 (es)
JP (1) JP5265003B2 (es)
KR (1) KR101677915B1 (es)
CN (1) CN102066355B (es)
AR (1) AR072143A1 (es)
AU (1) AU2009259440B2 (es)
BR (1) BRPI0914788B1 (es)
CA (1) CA2728058C (es)
CL (1) CL2010001442A1 (es)
DK (1) DK2297132T3 (es)
ES (1) ES2536728T3 (es)
HU (1) HUE025533T2 (es)
IL (1) IL208371A (es)
MX (1) MX2010013258A (es)
NZ (1) NZ588488A (es)
PL (1) PL2297132T3 (es)
RU (1) RU2524212C2 (es)
TW (1) TWI440635B (es)
WO (1) WO2009153215A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005061623A1 (de) 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen
NZ586868A (en) * 2008-03-28 2012-02-24 Boehringer Ingelheim Int Process for preparing orally administered dabigatran formulations
AU2009272796A1 (en) * 2008-07-14 2010-01-21 Boehringer Ingelheim International Gmbh Method for manufacturing medicinal compounds containing dabigatran
NZ592616A (en) 2008-11-11 2013-04-26 Boehringer Ingelheim Int Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved safety profile over conventional warfarin therapy
US8399678B2 (en) 2009-11-18 2013-03-19 Boehringer Ingelheim International Gmbh Process for the manufacture of dabigatran etexilate
US9006448B2 (en) 2010-12-06 2015-04-14 Msn Laboratories Private Limited Process for the preparation of benzimidazole derivatives and its salts
HUP1100244A2 (hu) 2011-05-11 2012-11-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Gyógyszeripari intermedierek és eljárás elõállításukra
CN102633713B (zh) * 2012-03-22 2013-12-11 南京工业大学 达比加群酯中间体及其制备方法、以及制备达比加群酯的方法
EP2834224B1 (en) 2012-04-02 2018-06-06 MSN Laboratories Limited Process for the preparation of benzimidazole derivatives and salts thereof
CN103420983B (zh) * 2012-05-24 2015-07-08 天津药物研究院 达比加群酯衍生物及其制备方法和用途
CN102850326B (zh) * 2012-06-19 2014-04-09 上海现代制药股份有限公司 一种达比加群酯中间体及其制备方法和应用
CN103772358A (zh) * 2014-01-07 2014-05-07 万特制药(海南)有限公司 一种制备达比加群酯的合成方法
CN103992241B (zh) * 2014-06-05 2016-08-24 雅本化学股份有限公司 N-取代苯基甘氨酸的制备方法
CN104003977B (zh) * 2014-06-05 2016-04-13 雅本化学股份有限公司 N-(2-氯甲基-1-甲基-1h-苯并咪唑-5-酰基)-n-(吡啶-2-基) -3-氨基丙酸乙酯的制备方法
CN105348148B (zh) * 2015-11-30 2017-12-26 山东新华制药股份有限公司 制备达比加群酯中间体缩合物的杂质的草酸盐的方法
CN109232535A (zh) * 2018-09-25 2019-01-18 重庆奥舍生物化工有限公司 一种非肽类凝血酶抑制剂达比加群酯的制备方法
CN116354952A (zh) * 2023-01-06 2023-06-30 宿迁盛基医药科技有限公司 一种达比加群酯关键中间体的合成工艺

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19924818A1 (de) * 1999-05-29 2000-11-30 Bayer Ag Substituierte Phenylcyclohexancarbonsäureamide
EP1609784A1 (de) * 2004-06-25 2005-12-28 Boehringer Ingelheim Pharma GmbH & Co.KG Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen
DE102005061624A1 (de) 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von Salzen von 4-(Benzimidazolylmethylamino)-Benzamidinen
DE102005061623A1 (de) * 2005-12-21 2007-06-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen
EP1956018A1 (de) * 2007-02-06 2008-08-13 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung eines Benzimidazolderivats
EP2271317B1 (de) * 2008-03-28 2017-04-19 Boehringer Ingelheim International GmbH Verfahren zur herstellung von säurepellets
NZ586868A (en) 2008-03-28 2012-02-24 Boehringer Ingelheim Int Process for preparing orally administered dabigatran formulations
EP2300431B1 (en) 2008-06-16 2016-01-06 Boehringer Ingelheim International GmbH Process for the manufacture of an intermediate in the synthesis of dabigatran
AU2009272796A1 (en) 2008-07-14 2010-01-21 Boehringer Ingelheim International Gmbh Method for manufacturing medicinal compounds containing dabigatran
US8399678B2 (en) * 2009-11-18 2013-03-19 Boehringer Ingelheim International Gmbh Process for the manufacture of dabigatran etexilate

Also Published As

Publication number Publication date
RU2011101500A (ru) 2012-07-27
AU2009259440B2 (en) 2014-05-29
US20110118471A1 (en) 2011-05-19
KR20110026412A (ko) 2011-03-15
PL2297132T3 (pl) 2015-07-31
NZ588488A (en) 2012-08-31
WO2009153215A1 (de) 2009-12-23
US8471033B2 (en) 2013-06-25
IL208371A (en) 2014-11-30
MX2010013258A (es) 2011-05-02
TW201008925A (en) 2010-03-01
ES2536728T3 (es) 2015-05-28
KR101677915B1 (ko) 2016-11-21
EP2297132A1 (de) 2011-03-23
TWI440635B (zh) 2014-06-11
DK2297132T3 (da) 2015-05-26
AU2009259440A1 (en) 2009-12-23
RU2524212C2 (ru) 2014-07-27
JP2011524403A (ja) 2011-09-01
CN102066355B (zh) 2015-07-01
CN102066355A (zh) 2011-05-18
EP2297132B1 (de) 2015-02-25
AR072143A1 (es) 2010-08-11
BRPI0914788A2 (pt) 2015-08-11
HUE025533T2 (en) 2016-05-30
JP5265003B2 (ja) 2013-08-14
CA2728058A1 (en) 2009-12-23
IL208371A0 (en) 2010-12-30
CA2728058C (en) 2016-05-17
BRPI0914788B1 (pt) 2020-04-07

Similar Documents

Publication Publication Date Title
CL2010001442A1 (es) Procedimiento de preparacion de una n-piridil-etoxicarboniletil-amida de un acido benzimidazolico, como intermediarios en la sintesis de etexilato de dabiogatran.
WO2013150545A3 (en) Process for preparation of benzimidazole derivatives and salts thereof
HK1217487A1 (zh) 用於治療成癮的作為乙醛脫氫酶- 抑制劑的 -氧基- -二氫-吡啶- -基 -芐基 -苯甲酰胺衍生物
DOP2016000285A (es) Procedimiento para la preparación de 4-­{4-­[({[4-­cloro-­3-­(trifluorometil)fenil]amino}carbonil)amino]-­3-­fluorofenoxi}-­n-­metilpiridina-­2-­carboxamida, sus sales y su monohidrato
TW201129555A (en) Process for the manufacture of dabigatrane etexilate
ECSP099509A (es) Procedimiento para la preparación de un derivado de bencimidazol
MX350121B (es) Derivados de n-(3-carbamoilfenil)-1h-pirazol-5-carboxamida y el uso de los mismos para el control de plagas de animales.
AP2013007233A0 (en) l)-3-(trifluoromethyl phenylÜ benzamide solubilizeModified release of 4-methyl-3-[[4-(3-pyridinyl)-2- pyrimidinyl]amino]-N-5-(4-methyl-IH-imidazol-I-yd using organic acids
WO2012077136A3 (en) Process for the preparation of benzimidazole derivatives and its salts
AR054278A1 (es) Formas polimorficas del ester etilico del acido 3-((2-{ (4-(hexiloxicarbonilamino- imino-metil)- fenilamino)-metil} -1-metil-h-bencimidazol-5- carbonil) piridin-2-il-amino)-propionico
NO20081476L (no) Substituerte benzimidazoler og fremgangsmater for fremstilling
EP3330254A3 (en) Method and process for preparation and production of deuterated omega-diphenylurea
EP2751060A4 (en) PROCESS FOR THE PRODUCTION OF BOTH SUCCINIC ACID AND BIOSOURCED 2,5-FURANDICARBOXYLIC ACID
CR20110554A (es) Formulaciones líquidas de sales de 1-[2-(2,4-dimetilfenilsulfanil)-fenil-piperazina
WO2014020555A3 (en) Improved process for preparing dabigatran etexilate mesylate
IL291738A (en) Production method for 1-(4-(4-(4,3-dichloro-2-fluorophenylamino)-7-methoxyquinazoline-6-yloxy-piperidin-1-yl)-prop-2-en-1-one hydrochloride and intermediates used for this
EA201100517A1 (ru) Способ получения дабигатрана и его промежуточные соединения
UA114601C2 (uk) Спосіб одержання ривароксабану та проміжних сполук, які одержано в даному способі
DOP2011000064A (es) Polimorfo b de la n-(2-aminofenil)-4-[n-(piridin-3-il)metoxicarbonilaminio-metil] benzamida (ms-275)
WO2013111163A3 (en) Process for the preparation of dabigatran etexilate mesylate and polymorphs of intermediates thereof
BR112012020629A2 (pt) forma cristalina, e, método para a terapia de um distúrbio
MY160625A (en) Process for preparing pan-cdk inhibitors of the formula(i), and intermediates in the preparation
UY35108A (es) Nuevo procedimiento de síntesis del (2e)-3-(3,4-dimetoxifenil) prop-2-enonitrilo, y aplicación a la síntesis de la ivabradina y de sus sales de adición a un ácido farmacéuticamente aceptable
GEP20156350B (en) New process for synthesis of ivabradine and their additional salts with pharmaceutically acceptable acid
EP2332932A4 (en) NEW CRYSTALLINE FORMS OF 4- (2-AMINOPYRIDIN-4-YL) -3- (4-fluoro-PHENYL) -1- (1,4,5,6-TETRAHYDRO-6-OXOPYRIDAZIN-3-YL) -1H-PYRAZOLE -METHANESULPHONATE AND METHOD OF MANUFACTURING THEREOF