AR072143A1 - Procedimiento para la preparacion de un producto intermedio para la sintesis de etexilato de dabigatran - Google Patents
Procedimiento para la preparacion de un producto intermedio para la sintesis de etexilato de dabigatranInfo
- Publication number
- AR072143A1 AR072143A1 ARP090102161A ARP090102161A AR072143A1 AR 072143 A1 AR072143 A1 AR 072143A1 AR P090102161 A ARP090102161 A AR P090102161A AR P090102161 A ARP090102161 A AR P090102161A AR 072143 A1 AR072143 A1 AR 072143A1
- Authority
- AR
- Argentina
- Prior art keywords
- synthesis
- procedure
- preparation
- intermediate product
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Reivindicacion 1: Procedimiento para preparar el compuesto de la formula (1) caracterizado porque una diamina de la formula (2) mediante reaccion con una oxadiazolona de la formula (3) se hace reaccionar para dar un compuesto de la formula (4) el cual se transforma, sin aislamiento y mediante hidrogenacion y adicion de cido p-toluensulfonico y amon¡aco, en la amidina de la formula (1).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08158364 | 2008-06-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR072143A1 true AR072143A1 (es) | 2010-08-11 |
Family
ID=39863126
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090102161A AR072143A1 (es) | 2008-06-16 | 2009-06-12 | Procedimiento para la preparacion de un producto intermedio para la sintesis de etexilato de dabigatran |
Country Status (20)
Country | Link |
---|---|
US (1) | US8471033B2 (es) |
EP (1) | EP2297132B1 (es) |
JP (1) | JP5265003B2 (es) |
KR (1) | KR101677915B1 (es) |
CN (1) | CN102066355B (es) |
AR (1) | AR072143A1 (es) |
AU (1) | AU2009259440B2 (es) |
BR (1) | BRPI0914788B1 (es) |
CA (1) | CA2728058C (es) |
CL (1) | CL2010001442A1 (es) |
DK (1) | DK2297132T3 (es) |
ES (1) | ES2536728T3 (es) |
HU (1) | HUE025533T2 (es) |
IL (1) | IL208371A (es) |
MX (1) | MX2010013258A (es) |
NZ (1) | NZ588488A (es) |
PL (1) | PL2297132T3 (es) |
RU (1) | RU2524212C2 (es) |
TW (1) | TWI440635B (es) |
WO (1) | WO2009153215A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005061623A1 (de) | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen |
NZ586868A (en) * | 2008-03-28 | 2012-02-24 | Boehringer Ingelheim Int | Process for preparing orally administered dabigatran formulations |
AU2009272796A1 (en) * | 2008-07-14 | 2010-01-21 | Boehringer Ingelheim International Gmbh | Method for manufacturing medicinal compounds containing dabigatran |
NZ592616A (en) | 2008-11-11 | 2013-04-26 | Boehringer Ingelheim Int | Method for treating or preventing thrombosis using dabigatran etexilate or a salt thereof with improved safety profile over conventional warfarin therapy |
US8399678B2 (en) | 2009-11-18 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dabigatran etexilate |
US9006448B2 (en) | 2010-12-06 | 2015-04-14 | Msn Laboratories Private Limited | Process for the preparation of benzimidazole derivatives and its salts |
HUP1100244A2 (hu) | 2011-05-11 | 2012-11-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Gyógyszeripari intermedierek és eljárás elõállításukra |
CN102633713B (zh) * | 2012-03-22 | 2013-12-11 | 南京工业大学 | 达比加群酯中间体及其制备方法、以及制备达比加群酯的方法 |
EP2834224B1 (en) | 2012-04-02 | 2018-06-06 | MSN Laboratories Limited | Process for the preparation of benzimidazole derivatives and salts thereof |
CN103420983B (zh) * | 2012-05-24 | 2015-07-08 | 天津药物研究院 | 达比加群酯衍生物及其制备方法和用途 |
CN102850326B (zh) * | 2012-06-19 | 2014-04-09 | 上海现代制药股份有限公司 | 一种达比加群酯中间体及其制备方法和应用 |
CN103772358A (zh) * | 2014-01-07 | 2014-05-07 | 万特制药(海南)有限公司 | 一种制备达比加群酯的合成方法 |
CN103992241B (zh) * | 2014-06-05 | 2016-08-24 | 雅本化学股份有限公司 | N-取代苯基甘氨酸的制备方法 |
CN104003977B (zh) * | 2014-06-05 | 2016-04-13 | 雅本化学股份有限公司 | N-(2-氯甲基-1-甲基-1h-苯并咪唑-5-酰基)-n-(吡啶-2-基) -3-氨基丙酸乙酯的制备方法 |
CN105348148B (zh) * | 2015-11-30 | 2017-12-26 | 山东新华制药股份有限公司 | 制备达比加群酯中间体缩合物的杂质的草酸盐的方法 |
CN109232535A (zh) * | 2018-09-25 | 2019-01-18 | 重庆奥舍生物化工有限公司 | 一种非肽类凝血酶抑制剂达比加群酯的制备方法 |
CN116354952A (zh) * | 2023-01-06 | 2023-06-30 | 宿迁盛基医药科技有限公司 | 一种达比加群酯关键中间体的合成工艺 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19924818A1 (de) * | 1999-05-29 | 2000-11-30 | Bayer Ag | Substituierte Phenylcyclohexancarbonsäureamide |
EP1609784A1 (de) * | 2004-06-25 | 2005-12-28 | Boehringer Ingelheim Pharma GmbH & Co.KG | Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen |
DE102005061624A1 (de) | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von Salzen von 4-(Benzimidazolylmethylamino)-Benzamidinen |
DE102005061623A1 (de) * | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verbessertes Verfahren zur Herstellung von 4-(Benzimidazolylmethylamino)-Benzamidinen und deren Salzen |
EP1956018A1 (de) * | 2007-02-06 | 2008-08-13 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung eines Benzimidazolderivats |
EP2271317B1 (de) * | 2008-03-28 | 2017-04-19 | Boehringer Ingelheim International GmbH | Verfahren zur herstellung von säurepellets |
NZ586868A (en) | 2008-03-28 | 2012-02-24 | Boehringer Ingelheim Int | Process for preparing orally administered dabigatran formulations |
EP2300431B1 (en) | 2008-06-16 | 2016-01-06 | Boehringer Ingelheim International GmbH | Process for the manufacture of an intermediate in the synthesis of dabigatran |
AU2009272796A1 (en) | 2008-07-14 | 2010-01-21 | Boehringer Ingelheim International Gmbh | Method for manufacturing medicinal compounds containing dabigatran |
US8399678B2 (en) * | 2009-11-18 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dabigatran etexilate |
-
2009
- 2009-06-12 HU HUE09765795A patent/HUE025533T2/en unknown
- 2009-06-12 AR ARP090102161A patent/AR072143A1/es active IP Right Grant
- 2009-06-12 NZ NZ588488A patent/NZ588488A/xx unknown
- 2009-06-12 WO PCT/EP2009/057266 patent/WO2009153215A1/de active Application Filing
- 2009-06-12 MX MX2010013258A patent/MX2010013258A/es active IP Right Grant
- 2009-06-12 CA CA2728058A patent/CA2728058C/en active Active
- 2009-06-12 AU AU2009259440A patent/AU2009259440B2/en active Active
- 2009-06-12 US US12/997,101 patent/US8471033B2/en active Active
- 2009-06-12 PL PL09765795T patent/PL2297132T3/pl unknown
- 2009-06-12 CN CN200980122791.2A patent/CN102066355B/zh active Active
- 2009-06-12 BR BRPI0914788A patent/BRPI0914788B1/pt active IP Right Grant
- 2009-06-12 KR KR1020107025345A patent/KR101677915B1/ko active IP Right Grant
- 2009-06-12 EP EP09765795.1A patent/EP2297132B1/de active Active
- 2009-06-12 DK DK09765795.1T patent/DK2297132T3/da active
- 2009-06-12 ES ES09765795.1T patent/ES2536728T3/es active Active
- 2009-06-12 RU RU2011101500/04A patent/RU2524212C2/ru active
- 2009-06-12 JP JP2011514003A patent/JP5265003B2/ja active Active
- 2009-06-15 TW TW098119967A patent/TWI440635B/zh active
-
2010
- 2010-10-03 IL IL208371A patent/IL208371A/en active IP Right Grant
- 2010-12-15 CL CL2010001442A patent/CL2010001442A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
RU2011101500A (ru) | 2012-07-27 |
AU2009259440B2 (en) | 2014-05-29 |
US20110118471A1 (en) | 2011-05-19 |
KR20110026412A (ko) | 2011-03-15 |
PL2297132T3 (pl) | 2015-07-31 |
NZ588488A (en) | 2012-08-31 |
WO2009153215A1 (de) | 2009-12-23 |
US8471033B2 (en) | 2013-06-25 |
IL208371A (en) | 2014-11-30 |
MX2010013258A (es) | 2011-05-02 |
TW201008925A (en) | 2010-03-01 |
ES2536728T3 (es) | 2015-05-28 |
KR101677915B1 (ko) | 2016-11-21 |
EP2297132A1 (de) | 2011-03-23 |
TWI440635B (zh) | 2014-06-11 |
DK2297132T3 (da) | 2015-05-26 |
AU2009259440A1 (en) | 2009-12-23 |
RU2524212C2 (ru) | 2014-07-27 |
JP2011524403A (ja) | 2011-09-01 |
CN102066355B (zh) | 2015-07-01 |
CN102066355A (zh) | 2011-05-18 |
EP2297132B1 (de) | 2015-02-25 |
BRPI0914788A2 (pt) | 2015-08-11 |
HUE025533T2 (en) | 2016-05-30 |
JP5265003B2 (ja) | 2013-08-14 |
CA2728058A1 (en) | 2009-12-23 |
IL208371A0 (en) | 2010-12-30 |
CA2728058C (en) | 2016-05-17 |
BRPI0914788B1 (pt) | 2020-04-07 |
CL2010001442A1 (es) | 2011-05-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR072143A1 (es) | Procedimiento para la preparacion de un producto intermedio para la sintesis de etexilato de dabigatran | |
MX2010007587A (es) | Compuestos que comprenden un grupo ciclobutoxi. | |
AR065196A1 (es) | Procedimiento para la preparacion de un derivado de bencimidazol | |
TN2011000286A1 (en) | Spiroheterocyclic n-oxypiperidines as pesticides | |
NZ600119A (en) | Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives | |
WO2009095933A3 (en) | Improved and novel process for the preparation of bosentan | |
WO2009134531A3 (en) | Total synthesis of salinosporamide a and analogs thereof | |
GEP20125512B (en) | Process for synthesis of agomelatin | |
MX2009007436A (es) | Derivados espirociclicos de acido tetronico. | |
AR074863A1 (es) | Proceso y compuestos intermedios para preparar un inhibidor de proteasa macrociclico del vhc | |
UA102289C2 (ru) | Гербициды, полученные из циклопентадиона | |
UA101835C2 (uk) | Спосіб отримання похідних 1-(2-галогенбіфеніл-4-іл)-циклопропанкарбонової кислоти | |
WO2010150279A3 (en) | Process for synthesis of diarylpyrimidine non-nucleoside reverse transcriptase inhibitor | |
HK1168102A1 (en) | Process for the preparation of a compound useful as an inhibitor of tafia | |
JO2928B1 (en) | A method for the preparation of ferroquine with amine by convergent reduction | |
WO2010004578A3 (en) | Novel and improved processes for the preparation of paliperidone | |
CL2011002158A1 (es) | Metodo para fabricar una composicion no termoestable donde se hace reaccionar epiclorhidrina y una amina, en una proporcion de 0,25 a 0,60 moles de epiclorhidrina por equivalente atomico de hidrogeno de amina; metodo para fabricar un adhesivo termoestable; metodo para fabricar un compuesto; precursor de un compuesto; y compuesto. | |
CR11635A (es) | Procedimiento de preparacion de combretastatina | |
MX2010009926A (es) | Nuevo proceso para la preparacion de derivados de acido ciclohexancarboxilico. | |
WO2011016052A3 (en) | Process for preparing pregabalin | |
UA102816C2 (ru) | Способ синтеза кристаллической формы v агомелатина | |
AR095548A1 (es) | Preparación de ácido 4-amino-2,4-dioxobutanoico | |
MX2013004193A (es) | Procedimiento para la preparacion de derivados de acido 3-(6-amino-piridin-3-il)-2-acrilico. | |
WO2007143014A3 (en) | Methods for preparing glutamic acid derivatives and intermediates thereof | |
WO2010029457A3 (en) | An improved process for preparing losartan potassium |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |