CL2009000090A1 - Anticuerpo que se une al receptor de tirosina quinasa b (trkb); composicion que comprende el anticuerpo; metodo para reducir los niveles de glucosa en la sangre y/o el peso corporal en un individuo. - Google Patents
Anticuerpo que se une al receptor de tirosina quinasa b (trkb); composicion que comprende el anticuerpo; metodo para reducir los niveles de glucosa en la sangre y/o el peso corporal en un individuo.Info
- Publication number
- CL2009000090A1 CL2009000090A1 CL2009000090A CL2009000090A CL2009000090A1 CL 2009000090 A1 CL2009000090 A1 CL 2009000090A1 CL 2009000090 A CL2009000090 A CL 2009000090A CL 2009000090 A CL2009000090 A CL 2009000090A CL 2009000090 A1 CL2009000090 A1 CL 2009000090A1
- Authority
- CL
- Chile
- Prior art keywords
- antibody
- trkb
- binds
- individual
- composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Anticuerpo que se une al receptor de tirosina quinasa b (trkb); composición que comprende el anticuerpo; método para reducir los niveles de glucosa en la sangre y/o el peso corporal en un individuo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2182008P | 2008-01-17 | 2008-01-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2009000090A1 true CL2009000090A1 (es) | 2009-07-24 |
Family
ID=40627621
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009000090A CL2009000090A1 (es) | 2008-01-17 | 2009-01-16 | Anticuerpo que se une al receptor de tirosina quinasa b (trkb); composicion que comprende el anticuerpo; metodo para reducir los niveles de glucosa en la sangre y/o el peso corporal en un individuo. |
Country Status (15)
Country | Link |
---|---|
US (1) | US8642035B2 (es) |
EP (1) | EP2235062A1 (es) |
JP (1) | JP5420568B2 (es) |
KR (1) | KR101290503B1 (es) |
CN (1) | CN102015769B (es) |
AR (1) | AR070202A1 (es) |
AU (1) | AU2009205937B2 (es) |
BR (1) | BRPI0906877A2 (es) |
CA (1) | CA2712298C (es) |
CL (1) | CL2009000090A1 (es) |
EA (1) | EA028621B1 (es) |
MX (1) | MX2010007841A (es) |
PE (1) | PE20091326A1 (es) |
TW (1) | TW200936608A (es) |
WO (1) | WO2009092049A1 (es) |
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EP2350075B1 (en) | 2008-09-22 | 2014-03-05 | Array Biopharma, Inc. | Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors |
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US9869295B2 (en) | 2015-05-07 | 2018-01-16 | General Electric Company | Attachment method to install components, such as tip extensions and winglets, to a wind turbine blade, as well as the wind turbine blade and component |
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US9869296B2 (en) | 2015-05-07 | 2018-01-16 | General Electric Company | Attachment method and system to install components, such as tip extensions and winglets, to a wind turbine blade |
EA201792679A1 (ru) | 2015-06-01 | 2018-06-29 | Локсо Онколоджи, Инк. | Способы диагностики и лечения злокачественной опухоли |
HUE053067T2 (hu) | 2015-07-16 | 2021-06-28 | Array Biopharma Inc | Helyettesített pirazolo[1,5-A]piridin vegyületek, mint RET kináz inhibitorok |
US10100805B2 (en) | 2015-10-12 | 2018-10-16 | General Electric Compant | Tip extension assembly for a wind turbine rotor blade |
RU2744852C2 (ru) | 2015-10-26 | 2021-03-16 | Локсо Онколоджи, Инк. | Точечные мутации в устойчивых к ингибитору trk злокачественных опухолях и связанные с ними способы |
US11078287B2 (en) | 2015-11-17 | 2021-08-03 | Glaxosmithkline Intellectual Property Development Limited | Binding agonist for treatment of neurological and other disorders |
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WO2019143991A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS |
WO2019143977A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
CA3087972C (en) | 2018-01-18 | 2023-01-10 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
CN108265036B (zh) * | 2018-01-26 | 2021-04-27 | 山东大学齐鲁医院 | 一种沉默t1蛋白的重组病毒及其构建方法与应用 |
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JP2022500383A (ja) | 2018-09-10 | 2022-01-04 | アレイ バイオファーマ インコーポレイテッド | Retキナーゼ阻害剤としての縮合複素環式化合物 |
US20220081438A1 (en) | 2018-12-19 | 2022-03-17 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases |
EP3898615A1 (en) | 2018-12-19 | 2021-10-27 | Array Biopharma, Inc. | 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives as fgfr inhibitors for treating cancer |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU22979A1 (es) | 2000-12-08 | 2004-09-09 | Centro Inmunologia Molecular | Combinación inmunoterapéutica para el tratamiento de tumores que sobre-expresan receptores con actividad quinasa en residuos de tirosina |
JP2006512895A (ja) * | 2002-06-28 | 2006-04-20 | ドマンティス リミテッド | リガンド |
WO2008058127A2 (en) * | 2006-11-09 | 2008-05-15 | Irm Llc | Agonist trkb antibodies and uses thereof |
CA2703329A1 (en) * | 2007-10-23 | 2009-04-30 | Novartis Ag | Use of trkb antibodies for the treatment of respiratory disorders |
-
2009
- 2009-01-16 JP JP2010543295A patent/JP5420568B2/ja not_active Expired - Fee Related
- 2009-01-16 US US12/864,636 patent/US8642035B2/en active Active
- 2009-01-16 CA CA2712298A patent/CA2712298C/en not_active Expired - Fee Related
- 2009-01-16 TW TW098101724A patent/TW200936608A/zh unknown
- 2009-01-16 CL CL2009000090A patent/CL2009000090A1/es unknown
- 2009-01-16 EP EP09702204A patent/EP2235062A1/en not_active Ceased
- 2009-01-16 KR KR1020107018153A patent/KR101290503B1/ko active IP Right Grant
- 2009-01-16 AU AU2009205937A patent/AU2009205937B2/en not_active Ceased
- 2009-01-16 BR BRPI0906877-5A patent/BRPI0906877A2/pt not_active Application Discontinuation
- 2009-01-16 MX MX2010007841A patent/MX2010007841A/es active IP Right Grant
- 2009-01-16 WO PCT/US2009/031345 patent/WO2009092049A1/en active Application Filing
- 2009-01-16 PE PE2009000058A patent/PE20091326A1/es not_active Application Discontinuation
- 2009-01-16 EA EA201001139A patent/EA028621B1/ru not_active IP Right Cessation
- 2009-01-16 CN CN200980109719.6A patent/CN102015769B/zh not_active Expired - Fee Related
- 2009-01-19 AR ARP090100159A patent/AR070202A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2009205937A1 (en) | 2009-07-23 |
AU2009205937B2 (en) | 2013-02-07 |
EA201001139A1 (ru) | 2011-04-29 |
KR20100103693A (ko) | 2010-09-27 |
TW200936608A (en) | 2009-09-01 |
EA028621B1 (ru) | 2017-12-29 |
CA2712298A1 (en) | 2009-07-23 |
JP5420568B2 (ja) | 2014-02-19 |
WO2009092049A1 (en) | 2009-07-23 |
CA2712298C (en) | 2015-11-24 |
US8642035B2 (en) | 2014-02-04 |
EP2235062A1 (en) | 2010-10-06 |
MX2010007841A (es) | 2010-09-28 |
AR070202A1 (es) | 2010-03-17 |
CN102015769B (zh) | 2014-12-10 |
US20110097326A1 (en) | 2011-04-28 |
PE20091326A1 (es) | 2009-09-18 |
KR101290503B1 (ko) | 2013-07-26 |
JP2011510021A (ja) | 2011-03-31 |
BRPI0906877A2 (pt) | 2015-07-28 |
CN102015769A (zh) | 2011-04-13 |
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