CL2008003525A1 - Conjugado de anticuerpo monoclonal humano anti-rg1 o una porcion de union a antigeno del mismo con moleculas asociadas, composicion que lo comprende; metodo in vitro para inhibir el crecimiento de una celula tumoral que expresa rg-1; uso de dicho conjugado para tratar el cancer - Google Patents
Conjugado de anticuerpo monoclonal humano anti-rg1 o una porcion de union a antigeno del mismo con moleculas asociadas, composicion que lo comprende; metodo in vitro para inhibir el crecimiento de una celula tumoral que expresa rg-1; uso de dicho conjugado para tratar el cancerInfo
- Publication number
- CL2008003525A1 CL2008003525A1 CL2008003525A CL2008003525A CL2008003525A1 CL 2008003525 A1 CL2008003525 A1 CL 2008003525A1 CL 2008003525 A CL2008003525 A CL 2008003525A CL 2008003525 A CL2008003525 A CL 2008003525A CL 2008003525 A1 CL2008003525 A1 CL 2008003525A1
- Authority
- CL
- Chile
- Prior art keywords
- conjugate
- antigen
- inhibiting
- growth
- tumor cell
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6869—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from a cell of the reproductive system: ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Conjugado de anticuerpo monoclonal humano anti-rg1 o una porción de enlace al antígeno del mismo con moléculas asociadas como citotoxinas; composición que lo comprende; y método para inhibir el crecimiento de una célula tumoral que expresarg-1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99169007P | 2007-11-30 | 2007-11-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008003525A1 true CL2008003525A1 (es) | 2010-01-22 |
Family
ID=40427118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2008003525A CL2008003525A1 (es) | 2007-11-30 | 2008-11-26 | Conjugado de anticuerpo monoclonal humano anti-rg1 o una porcion de union a antigeno del mismo con moleculas asociadas, composicion que lo comprende; metodo in vitro para inhibir el crecimiento de una celula tumoral que expresa rg-1; uso de dicho conjugado para tratar el cancer |
Country Status (18)
Country | Link |
---|---|
US (1) | US20110020329A1 (es) |
EP (1) | EP2211908A2 (es) |
JP (1) | JP2011505371A (es) |
KR (1) | KR20100101122A (es) |
CN (1) | CN101951960A (es) |
AR (1) | AR069746A1 (es) |
AU (1) | AU2008331507A1 (es) |
BR (1) | BRPI0819765A2 (es) |
CA (1) | CA2707443A1 (es) |
CL (1) | CL2008003525A1 (es) |
CO (1) | CO6210734A2 (es) |
EA (1) | EA201000921A1 (es) |
IL (1) | IL206060A0 (es) |
MX (1) | MX2010005683A (es) |
NZ (1) | NZ586514A (es) |
TW (1) | TW200930407A (es) |
WO (1) | WO2009073524A2 (es) |
ZA (1) | ZA201003729B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006008096A1 (en) * | 2004-07-16 | 2006-01-26 | Micromet Ag | Expression-enhanced polypeptides |
JP5677970B2 (ja) | 2008-11-03 | 2015-02-25 | シンタルガ・ビーブイ | 新規cc−1065類似体およびその複合体 |
LT3056203T (lt) | 2010-04-21 | 2018-03-26 | Syntarga B.V. | Konjugatai cc-1065 analogų ir bifunkcinių linkerių |
CA2800769C (en) * | 2010-05-27 | 2021-11-02 | Genmab A/S | Monoclonal antibodies against her2 epitope |
CA2800785C (en) | 2010-05-27 | 2019-09-24 | Genmab A/S | Monoclonal antibodies against her2 |
US8852599B2 (en) | 2011-05-26 | 2014-10-07 | Bristol-Myers Squibb Company | Immunoconjugates, compositions for making them, and methods of making and use |
LT3092010T (lt) | 2014-01-10 | 2018-10-25 | Synthon Biopharmaceuticals B.V. | Metodas, skirtas gryninimui cys-sujungtų antikūno-vaisto konjugatų |
AU2015210578B2 (en) * | 2014-01-29 | 2020-04-16 | Jiangsu Hengrui Medicine Co., Ltd. | Ligand-cytotoxic drug conjugate, preparation method therefor, and uses thereof |
EP3661966A4 (en) | 2017-07-31 | 2021-07-21 | Tizona Therapeutics | ANTI-CD39 ANTIBODIES, COMPOSITIONS INCLUDING ANTI-CD39 ANTIBODIES AND METHODS OF USE OF ANTI-CD39 ANTIBODIES |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4978757A (en) * | 1984-02-21 | 1990-12-18 | The Upjohn Company | 1,2,8,8a-tetrahydrocyclopropa (C) pyrrolo [3,2-e)]-indol-4(5H)-ones and related compounds |
US4912227A (en) * | 1984-02-21 | 1990-03-27 | The Upjohn Company | 1,2,8,8A-tetrahydrocyclopropa(c)pyrrolo(3,2-e)-indol-4-(5H)-ones and related compounds |
US5332837A (en) * | 1986-12-19 | 1994-07-26 | The Upjohn Company | CC-1065 analogs |
US5084468A (en) * | 1988-08-11 | 1992-01-28 | Kyowa Hakko Kogyo Co., Ltd. | Dc-88a derivatives |
JP2598116B2 (ja) * | 1988-12-28 | 1997-04-09 | 協和醗酵工業株式会社 | 新規物質dc113 |
JP2510335B2 (ja) * | 1989-07-03 | 1996-06-26 | 協和醗酵工業株式会社 | Dc―88a誘導体 |
US5187186A (en) * | 1989-07-03 | 1993-02-16 | Kyowa Hakko Kogyo Co., Ltd. | Pyrroloindole derivatives |
AU648313B2 (en) * | 1990-04-25 | 1994-04-21 | Pharmacia & Upjohn Company | Novel CC-1065 analogs |
US6214345B1 (en) * | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
WO1995029179A1 (fr) * | 1994-04-22 | 1995-11-02 | Kyowa Hakko Kogyo Co., Ltd. | Derive de dc-89 |
JPH07309761A (ja) * | 1994-05-20 | 1995-11-28 | Kyowa Hakko Kogyo Co Ltd | デュオカルマイシン誘導体の安定化法 |
US5871969A (en) * | 1996-02-12 | 1999-02-16 | Human Genome Sciences, Inc. | Nucleic acids encoding human neuronal attachment factor-1 |
US6682902B2 (en) * | 1999-12-16 | 2004-01-27 | Schering Aktiengesellschaft | DNA encoding a novel RG1 polypeptide |
WO2002096910A1 (en) * | 2001-05-31 | 2002-12-05 | Medarex, Inc. | Cytotoxins, prodrugs, linkers and stabilizers useful therefor |
EP1423110A4 (en) * | 2001-09-07 | 2005-04-27 | Scripps Research Inst | CBI ANALOGUE OF CC-1065 AND DUOCARMYCINES |
US7091186B2 (en) * | 2001-09-24 | 2006-08-15 | Seattle Genetics, Inc. | p-Amidobenzylethers in drug delivery agents |
CN1826138B (zh) * | 2003-07-22 | 2012-05-23 | 舍林股份公司 | Rg1抗体及其用途 |
JP4806680B2 (ja) * | 2004-05-19 | 2011-11-02 | メダレックス インコーポレイテッド | 自己犠牲リンカー及び薬剤複合体 |
US7691962B2 (en) * | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
US7714016B2 (en) * | 2005-04-08 | 2010-05-11 | Medarex, Inc. | Cytotoxic compounds and conjugates with cleavable substrates |
EP1940470B1 (en) * | 2005-09-26 | 2013-04-17 | Medarex, Inc. | Antibody-drug conjugates and their use |
WO2007059404A2 (en) * | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
WO2007137760A2 (en) * | 2006-05-25 | 2007-12-06 | Bayer Schering Pharma Aktiengesellschaft | Dimeric molecular complexes |
-
2008
- 2008-11-26 MX MX2010005683A patent/MX2010005683A/es not_active Application Discontinuation
- 2008-11-26 WO PCT/US2008/084899 patent/WO2009073524A2/en active Application Filing
- 2008-11-26 EA EA201000921A patent/EA201000921A1/ru unknown
- 2008-11-26 CN CN2008801259196A patent/CN101951960A/zh active Pending
- 2008-11-26 EP EP08858236A patent/EP2211908A2/en not_active Withdrawn
- 2008-11-26 BR BRPI0819765 patent/BRPI0819765A2/pt not_active IP Right Cessation
- 2008-11-26 TW TW097145816A patent/TW200930407A/zh unknown
- 2008-11-26 AU AU2008331507A patent/AU2008331507A1/en not_active Abandoned
- 2008-11-26 JP JP2010536173A patent/JP2011505371A/ja not_active Withdrawn
- 2008-11-26 NZ NZ586514A patent/NZ586514A/en not_active IP Right Cessation
- 2008-11-26 AR ARP080105135A patent/AR069746A1/es not_active Application Discontinuation
- 2008-11-26 KR KR1020107014394A patent/KR20100101122A/ko not_active Application Discontinuation
- 2008-11-26 US US12/745,337 patent/US20110020329A1/en not_active Abandoned
- 2008-11-26 CA CA2707443A patent/CA2707443A1/en not_active Abandoned
- 2008-11-26 CL CL2008003525A patent/CL2008003525A1/es unknown
-
2010
- 2010-05-25 ZA ZA2010/03729A patent/ZA201003729B/en unknown
- 2010-05-28 CO CO10064681A patent/CO6210734A2/es not_active Application Discontinuation
- 2010-05-30 IL IL206060A patent/IL206060A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2008331507A1 (en) | 2009-06-11 |
CO6210734A2 (es) | 2010-10-20 |
CA2707443A1 (en) | 2009-06-11 |
AR069746A1 (es) | 2010-02-17 |
IL206060A0 (en) | 2010-11-30 |
ZA201003729B (en) | 2011-08-31 |
EA201000921A1 (ru) | 2010-12-30 |
NZ586514A (en) | 2012-05-25 |
MX2010005683A (es) | 2010-06-11 |
TW200930407A (en) | 2009-07-16 |
EP2211908A2 (en) | 2010-08-04 |
US20110020329A1 (en) | 2011-01-27 |
WO2009073524A2 (en) | 2009-06-11 |
KR20100101122A (ko) | 2010-09-16 |
WO2009073524A3 (en) | 2009-12-10 |
CN101951960A (zh) | 2011-01-19 |
JP2011505371A (ja) | 2011-02-24 |
BRPI0819765A2 (pt) | 2015-05-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2008003525A1 (es) | Conjugado de anticuerpo monoclonal humano anti-rg1 o una porcion de union a antigeno del mismo con moleculas asociadas, composicion que lo comprende; metodo in vitro para inhibir el crecimiento de una celula tumoral que expresa rg-1; uso de dicho conjugado para tratar el cancer | |
CL2019003266A1 (es) | Anticuerpos anti-sirpalfa. | |
CL2008003526A1 (es) | Conjugado de anticuerpo-molécula asociada que comprende un anticuerpo monoclonal humano anti b7-h4/08e/b7x/b7s1/bl-cam/b3/leu-14/lyb-8 humana; composición que lo comprende; método in vitro de inhibición de célula tumoral que expresa b7-h4/08e/b7x/b7s1/bl-cam/b3/leu-14/lyb-8; y uso para tratar cancer. | |
CL2007003622A1 (es) | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. | |
CY1117859T1 (el) | Αντισωματα και ανοσοσυζευγματα anti-cd79b και μεθοδοι χρησης | |
EA201390472A1 (ru) | Новые молекулы, связывающиеся с egfr, и их иммуноконъюгаты | |
CL2017000954A1 (es) | Moléculas de unión a antígeno biespecificas activadoras de células t | |
PH12020551689A1 (en) | Her2-targeting antigen binding molecules comprising 4-1bbl | |
CY1115700T1 (el) | Αντισωματα και ανοσοσυζευγματα αντι-cd79b και μεθοδοι χρησης | |
CL2011003229A1 (es) | Compuestos conjugados derivados de criptoficina; procedimiento de preparacion; y su uso para el tratamiento del cancer. | |
PE20120902A1 (es) | Anticuerpos anti-egfl7 humanizados | |
MY173839A (en) | Cd37-binding molecules and immunoconjugates thereof | |
AR077866A1 (es) | Terapia de combinacion de un anticuerpo cd20 afucosilado y bendamustina | |
MX2015013203A (es) | Conjugados de anticuerpo - farmaco. | |
EA201590174A1 (ru) | Иммуноконъюгаты, содержащие анти-cd22 антитела | |
ATE526987T1 (de) | Dr5-antikörper und deren verwendung | |
ECSP12011885A (es) | Inmunoglobulinas con dominio variable dual | |
MX341076B (es) | Formulaciones estables de anticuerpos para el receptor humano pd-1 de meurte programada y tratamientos relacionados. | |
EA201171367A1 (ru) | Винилиндазолильные соединения | |
CR20110553A (es) | Terapia complementaria contra el cáncer | |
AR074756A1 (es) | Anticuerpos contra la angiopoyetina-2 humana | |
UA103004C2 (ru) | Гуманизированное антитело против cd79b и иммуноконъюгаты и способы применения | |
CL2008002782A1 (es) | Anticuerpo anti-bv8 neutralizante; composicion que lo comprende; y su uso para tratar tumores en humanos previamente tratados con un antagonista del factor de crecimiento endotelial vascular. | |
CL2021001260A1 (es) | Anticuerpos anti-sirpa humanizados | |
BR112015027309A2 (pt) | anticorpo, composição, método de tratamento e uso de um anticorpo |