CL2004000805A1 - Compuestos derivados de 7-aza-quinazolina sustituida, inhibidores de quinasa p38; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar artritis, enfermedad de crohn, alzheimer, asma, ataque al corazon. - Google Patents

Compuestos derivados de 7-aza-quinazolina sustituida, inhibidores de quinasa p38; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar artritis, enfermedad de crohn, alzheimer, asma, ataque al corazon.

Info

Publication number: CL2004000805A1
Authority: CL; Chile
Prior art keywords: quinazolina; quinasa; aza; crohn; alzheimer
Prior art date: 2003-04-16

Application number

CL200400805A

Other languages

English (en)

Inventor

James Dewdney David Mich Nolan

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-16

Filing date

2004-04-15

Publication date

2005-02-04

2004-04-15 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2005-02-04 Publication of CL2004000805A1 publication Critical patent/CL2004000805A1/es

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

CL200400805A 2003-04-16 2004-04-15 Compuestos derivados de 7-aza-quinazolina sustituida, inhibidores de quinasa p38; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar artritis, enfermedad de crohn, alzheimer, asma, ataque al corazon. CL2004000805A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US46322903P	2003-04-16	2003-04-16

Publications (1)

Publication Number	Publication Date
CL2004000805A1 true CL2004000805A1 (es)	2005-02-04

Family

ID=33300055

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200400805A CL2004000805A1 (es)	2003-04-16	2004-04-15	Compuestos derivados de 7-aza-quinazolina sustituida, inhibidores de quinasa p38; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar artritis, enfermedad de crohn, alzheimer, asma, ataque al corazon.

Country Status (16)

Country	Link
US (2)	US7189731B2 (es)
EP (1)	EP1620105B1 (es)
JP (1)	JP2006523640A (es)
KR (1)	KR20060006037A (es)
CN (1)	CN1774250A (es)
AR (1)	AR044515A1 (es)
AU (1)	AU2004229163A1 (es)
BR (1)	BRPI0409405A (es)
CA (1)	CA2520785A1 (es)
CL (1)	CL2004000805A1 (es)
DE (1)	DE602004004259T2 (es)
ES (1)	ES2279361T3 (es)
MX (1)	MXPA05010975A (es)
RU (1)	RU2005135329A (es)
TW (1)	TW200503722A (es)
WO (1)	WO2004091625A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE102004020908A1 (de) *	2004-04-28	2005-11-17	Grünenthal GmbH	Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen
WO2006056863A1 (en) *	2004-11-23	2006-06-01	Ranbaxy Laboratories Limited	Pyrido’2, 3-d!pyrimidines as anti-inflammatory agents
ES2303758B1 (es) *	2006-02-20	2009-08-13	Laboratorios Almirall S.A.	Nuevos derivados de piridin-3-amina.
EP1992344A1 (en)	2007-05-18	2008-11-19	Institut Curie	P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
CN105541836A (zh)	2009-03-11	2016-05-04	奥克兰联合服务有限公司	激酶抑制剂的前药形式及其在治疗中的用途
MX336332B (es) *	2009-09-02	2016-01-15	Auckland Uniservices Ltd	Inhibidores de cinasa, formas de profarmaco de los mismos y su uso en terapia.
US20190060286A1 (en)	2016-02-29	2019-02-28	University Of Florida Research Foundation, Incorpo	Chemotherapeutic Methods
CA3128468A1 (en)	2017-10-05	2019-04-11	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
US10342786B2 (en)	2017-10-05	2019-07-09	Fulcrum Therapeutics, Inc.	P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1199768A (en) *	1966-10-31	1970-07-22	Pfizer & Co C	Nitrogen Heterocycles and process for their preparation
JPS4936700A (es) *	1972-08-16	1974-04-05
US4672116A (en) *	1985-12-20	1987-06-09	Ortho Pharmaceutical Corporation	Substituted 5,6-dialkoxyquinazoline derivatives
US5084463A (en) *	1989-12-11	1992-01-28	American Home Products Corporation	N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity
US20020061879A1 (en) *	1996-02-02	2002-05-23	Garvey David S.	Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
CO4940469A1 (es)	1997-03-05	2000-07-24	Sugen Inc	Composicion oral de estabilidad mejorada que comprende un derivado de indolinona y una mezcla de gliceridos o esteres de polietilenglicol
US6313294B1 (en) *	1998-02-04	2001-11-06	Development Center For Biotechnology	Process for preparing amides
EP1230225A2 (en)	1999-11-01	2002-08-14	Eli Lilly And Company	Pharmaceutically active 4-substituted pyrimidine derivatives
BR0015718A (pt)	1999-11-22	2002-07-23	Warner Lambert Co	Quinazolinas e seu uso para inibição de enzimas de cinase dependente de ciclina
EP1110552A1 (en)	1999-12-22	2001-06-27	Aventis Pharma S.A.	Use of a compound with affinity for the mitochondrial benzodiazepine receptor in cancer therapy
US6605615B2 (en)	2000-03-01	2003-08-12	Tularik Inc.	Hydrazones and analogs as cholesterol lowering agents
DE60125373T2 (de)	2000-07-26	2007-10-18	Smithkline Beecham P.L.C., Brentford	Aminopiperidin chinoline und ihre azaisosteren analoga mit antibakterieller wirkung
AUPR213700A0 (en)	2000-12-18	2001-01-25	Biota Scientific Management Pty Ltd	Antiviral agents
HU229604B1 (en) *	2001-02-12	2014-02-28	Hoffmann La Roche	6-substituted pyrido-pyrimidines, process for their preparation and pharmaceutical compositions containing them
EP1389209B1 (en)	2001-04-24	2009-04-08	Purdue Research Foundation	Folate mimetics and folate-receptor binding conjugates thereof
WO2002090360A1 (en) *	2001-05-10	2002-11-14	Smithkline Beecham Corporation	Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
DE60316581T2 (de) *	2002-08-06	2008-07-03	F. Hoffmann-La Roche Ag	6-alkoxypyridopyrimidine als inhibitoren der p-38-map-kinase

2004
- 2004-04-13 RU RU2005135329/04A patent/RU2005135329A/ru not_active Application Discontinuation
- 2004-04-13 CN CNA2004800099562A patent/CN1774250A/zh active Pending
- 2004-04-13 JP JP2006505106A patent/JP2006523640A/ja active Pending
- 2004-04-13 DE DE602004004259T patent/DE602004004259T2/de not_active Expired - Fee Related
- 2004-04-13 ES ES04726958T patent/ES2279361T3/es not_active Expired - Lifetime
- 2004-04-13 BR BRPI0409405-0A patent/BRPI0409405A/pt not_active Application Discontinuation
- 2004-04-13 KR KR1020057019705A patent/KR20060006037A/ko not_active Application Discontinuation
- 2004-04-13 EP EP04726958A patent/EP1620105B1/en not_active Expired - Lifetime
- 2004-04-13 CA CA002520785A patent/CA2520785A1/en not_active Abandoned
- 2004-04-13 WO PCT/EP2004/003883 patent/WO2004091625A1/en active IP Right Grant
- 2004-04-13 MX MXPA05010975A patent/MXPA05010975A/es not_active Application Discontinuation
- 2004-04-13 AU AU2004229163A patent/AU2004229163A1/en not_active Abandoned
- 2004-04-15 US US10/824,980 patent/US7189731B2/en not_active Expired - Fee Related
- 2004-04-15 AR ARP040101263A patent/AR044515A1/es unknown
- 2004-04-15 TW TW093110567A patent/TW200503722A/zh unknown
- 2004-04-15 CL CL200400805A patent/CL2004000805A1/es unknown
2007
- 2007-01-09 US US11/651,320 patent/US20070135459A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2004091625A1 (en)	2004-10-28
BRPI0409405A (pt)	2006-04-25
RU2005135329A (ru)	2006-08-10
EP1620105A1 (en)	2006-02-01
ES2279361T3 (es)	2007-08-16
DE602004004259T2 (de)	2007-11-15
CA2520785A1 (en)	2004-10-28
US20040209903A1 (en)	2004-10-21
AR044515A1 (es)	2005-09-14
DE602004004259D1 (de)	2007-02-22
CN1774250A (zh)	2006-05-17
US20070135459A1 (en)	2007-06-14
KR20060006037A (ko)	2006-01-18
EP1620105B1 (en)	2007-01-10
JP2006523640A (ja)	2006-10-19
AU2004229163A1 (en)	2004-10-28
TW200503722A (en)	2005-02-01
US7189731B2 (en)	2007-03-13
MXPA05010975A (es)	2005-11-28

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